Teresa Borrás, Michelle Stepankoff, John Danias
PURPOSE OF REVIEW: To provide the latest advances on the future use of gene therapy for the treatment of glaucoma. RECENT FINDINGS: In preclinical studies, a number of genes have been shown to be able to reduce elevated intraocular pressure (IOP), and to exert neuroprotection of the retinal ganglion cells. These genes target various mechanisms of action and include among others: MMP3, PLAT, IκB, GLIS, SIRT, Tie-2, AQP1. Some of these as well as some previously identified genes (MMP3, PLAT, BDNF, C3, TGFβ, MYOC, ANGPTL7) are starting to move onto drug development...
December 21, 2023: Current Opinion in Ophthalmology