journal
https://read.qxmd.com/read/38170785/intravitreal-enzyme-replacement-for-inherited-retinal-diseases
#21
JOURNAL ARTICLE
Ana Catalina Rodriguez-Martinez, James Wawrzynski, Robert H Henderson
PURPOSE OF REVIEW: This paper provides an update on intravitreal (IVT) enzyme replacement therapy (ERT) in metabolic retinal diseases; particularly neuronal ceroid lipofuscinosis type 2 (CLN2) also known as Batten disease. RECENT FINDINGS: ERT is being explored in CLN2 related Batten disease, a fatal neurodegenerative condition associated with retinopathy and blindness that is caused by the deficiency of lysosomal enzyme TPP1. Cerliponase alfa, a recombinant human tripeptidyl-peptidase1 (rhTPP1) administered by intraventricular infusions has been demonstrated to slow the rate of neurodegenerative decline but not retinopathy...
December 27, 2023: Current Opinion in Ophthalmology
https://read.qxmd.com/read/38117686/leber-hereditary-optic-neuropathy-gene-therapy
#22
JOURNAL ARTICLE
Byron L Lam
PURPOSE OF REVIEW: To discuss relevant clinical outcomes, challenges, and future opportunities of gene therapy in Leber hereditary optic neuropathy (LHON). RECENT FINDINGS: Results of G11778A LHON Phase 3 randomized clinical trials with unilateral intravitreal rAAV2/2-ND4 allotopic gene therapy show good safety and unexpected bilateral partial improvements of BCVA (best-corrected visual acuity) with mean logMAR BCVA improvements of up to near ∼0.3 logMAR (3 lines) in the treated eyes and ∼0...
December 21, 2023: Current Opinion in Ophthalmology
https://read.qxmd.com/read/38117663/genes-as-drugs-for-glaucoma-latest-advances
#23
JOURNAL ARTICLE
Teresa Borrás, Michelle Stepankoff, John Danias
PURPOSE OF REVIEW: To provide the latest advances on the future use of gene therapy for the treatment of glaucoma. RECENT FINDINGS: In preclinical studies, a number of genes have been shown to be able to reduce elevated intraocular pressure (IOP), and to exert neuroprotection of the retinal ganglion cells. These genes target various mechanisms of action and include among others: MMP3, PLAT, IκB, GLIS, SIRT, Tie-2, AQP1. Some of these as well as some previously identified genes (MMP3, PLAT, BDNF, C3, TGFβ, MYOC, ANGPTL7) are starting to move onto drug development...
December 21, 2023: Current Opinion in Ophthalmology
https://read.qxmd.com/read/38108372/glaucoma-surgical-procedures-under-development
#24
JOURNAL ARTICLE
Ariana M Levin, Arsham Sheybani
PURPOSE OF REVIEW: Rapid innovation in glaucoma surgery is expanding surgical options in the angle, subconjunctival space, and supraciliary space. RECENT FINDINGS: Advancements in glaucoma surgery make it possible for surgeons to provide treatments with less risk. In particular, new devices and lasers are available for minimally invasive glaucoma surgeries. There are also new implants and techniques for bleb-forming glaucoma surgery. SUMMARY: As glaucoma surgeons have access to an increasing number of procedures, devices, and treatments, it is important for evidence to drive decision-making...
December 15, 2023: Current Opinion in Ophthalmology
https://read.qxmd.com/read/38059758/a-review-of-posterior-chamber-phakic-intraocular-lenses
#25
JOURNAL ARTICLE
Dan Z Reinstein, Cheryl MacGregor, Timothy J Archer, Ruchi Gupta, Joseph G Potter
PURPOSE OF REVIEW: Posterior chamber phakic intraocular lenses (pIOLs) are increasing in popularity as a viable alternative to laser refractive surgery. The purpose of this review is to evaluate the recent updates to pIOLs and to assess the advancements and safety of the procedure. RECENT FINDINGS: Accurate lens sizing is the key determinant to suitable vault prediction, advancements to sizing formulae including the use of very high frequency (VHF) digital ultrasound and the application of artificial intelligence and machine learning has led to improved vault prediction and safety...
December 7, 2023: Current Opinion in Ophthalmology
https://read.qxmd.com/read/38018807/artificial-intelligence-for-glaucoma-state-of-the-art-and-future-perspectives
#26
JOURNAL ARTICLE
Rafael Correia Barão, Ruben Hemelings, Luís Abegão Pinto, Marta Pazos, Ingeborg Stalmans
PURPOSE OF REVIEW: To address the current role of artificial intelligence (AI) in the field of glaucoma. RECENT FINDINGS: Current deep learning (DL) models concerning glaucoma diagnosis have shown consistently improving diagnostic capabilities, primarily based on color fundus photography and optical coherence tomography, but also with multimodal strategies. Recent models have also suggested that AI may be helpful in detecting and estimating visual field progression from different input data...
November 30, 2023: Current Opinion in Ophthalmology
https://read.qxmd.com/read/38018796/how-much-does-cataract-surgery-contribute-to-intraocular-pressure-lowering
#27
JOURNAL ARTICLE
Jasdeep Sabharwal, Anupam K Garg, Pradeep Y Ramulu
PURPOSE OF REVIEW: To review the literature evaluating the effect of cataract surgery on intraocular pressure (IOP) in patients with glaucoma. RECENT FINDINGS: Recent high-quality secondary analyses of large and primary trials continue to show IOP lowering following cataract surgery. Likewise, cataract surgery remains a key treatment for angle closure glaucoma. Some micro-invasive glaucoma surgeries (MIGS) have strong evidence to be performed at the time of cataract surgery...
November 30, 2023: Current Opinion in Ophthalmology
https://read.qxmd.com/read/38018802/cataract-surgery-in-setting-of-ocular-surface-disease
#28
JOURNAL ARTICLE
Enrica Sarnicola, Caterina Sarnicola, Maddalena De Bernardo, Nicola Rosa, Vincenzo Sarnicola
PURPOSE OF REVIEW: The purpose of this article is to review the available strategies to successfully identify and manage ocular surface disease (OSD) pre, intra and post-cataract surgery. RECENT FINDINGS: Cataract surgery and OSD have an intricate relationship: the surgical procedure can induce or exaggerate OSD symptoms, while OSD can negatively impact surgical refractive outcomes and increase the rate of postoperative complications. SUMMARY: Improving the health and stability ocular surface is the key to enhance post cataract surgery refractive outcomes and avoid complications...
November 28, 2023: Current Opinion in Ophthalmology
https://read.qxmd.com/read/38018801/impact-of-smoking-on-glaucoma
#29
JOURNAL ARTICLE
Golnoush Mahmoudinezhad, Leo Meller, Sasan Moghimi
PURPOSE OF REVIEW: Assessing whether lifestyle related factors play a role in causing primary open-angle glaucoma (POAG) is of great value to clinicians, public health experts and policy makers. Smoking is a major global public health concern and contributes to ocular diseases such as cataracts, and age-related macular degeneration through ischemic and oxidative mechanisms. Recently, smoking has been investigated as a modifiable risk factor for glaucoma. In the presence of an association with glaucoma, provision of advice and information regarding smoking to patients may help reduce the burden of disease caused by POAG...
November 28, 2023: Current Opinion in Ophthalmology
https://read.qxmd.com/read/37962882/cataract-surgery-after-corneal-refractive-surgery-preoperative-considerations-and-management
#30
JOURNAL ARTICLE
Darren Sj Ting, Damien Gatinel, Marcus Ang
PURPOSE OF REVIEW: Corneal refractive surgery (CRS) is one of the most popular eye procedures, with more than 40 million cases performed globally. As CRS-treated patients age and develop cataract, the number of cases that require additional preoperative considerations and management will increase around the world. Thus, we provide an up-to-date, concise overview of the considerations and outcomes of cataract surgery in eyes with previous CRS, including surface ablation, laser in-situ keratomileusis (LASIK), and small-incision lenticule extraction (SMILE)...
November 14, 2023: Current Opinion in Ophthalmology
https://read.qxmd.com/read/37962881/refractive-cataract-surgery
#31
JOURNAL ARTICLE
Rhea Narang, Ashvin Agarwal
PURPOSE OF REVIEW: The aim of this study to provide an overview of recent publications and opinions in refractive cataract surgery. RECENT FINDINGS: With the advent of intraocular lenses (IOLs) on different platforms, the surgeon has a wide arena of types of IOL to choose, depending on the patient's visual requirement. Optimization of the tear film, integrating tomography and topography devices for appropriate keratometry values, biometry, use of advanced formulas for IOL power calculation and application of newer IOLs can help achieve target refraction in cases scheduled for cataract surgery...
November 14, 2023: Current Opinion in Ophthalmology
https://read.qxmd.com/read/37922421/online-intraocular-lens-calculation
#32
JOURNAL ARTICLE
Dante Buonsanti, Miguel Raimundo, Oliver Findl
PURPOSE OF REVIEW: To showcase the majority of online intraocular lens (IOL) calculation tools and highlight some of their characteristics. RECENT FINDINGS: Online tools are available for preoperative and postoperative IOL-related calculations, including IOL power and toricity selection for standard patients, patients who underwent prior refractive surgery, keratoconus, limbal relaxing incisions for astigmatism management, realignment of a misplaced or rotated toric IOL, surgical induced astigmatism (SIA), formulae comparison, and other tools...
November 6, 2023: Current Opinion in Ophthalmology
https://read.qxmd.com/read/37922412/understanding-racial-disparities-of-glaucoma
#33
JOURNAL ARTICLE
Viviana Barquet-Pizá, Carla J Siegfried
PURPOSE OF REVIEW: Increased prevalence, earlier onset, and more rapid progression to vision loss from glaucoma has demonstrated racial disparity in numerous studies over decades. Precise etiologies of these important differences among patients of African and Hispanic ancestral background have not been elucidated. This review focuses on currently available epidemiologic/population, genetic, socioeconomic and physiologic studies of racial disparities in this blinding disease. RECENT FINDINGS: In depth reviews of several landmark studies of glaucoma prevalence in various racial groups have highlighted potential challenges of lack of recruitment of diverse populations in genetic studies and clinical trials, challenges of racial stratification of subjects, and the impact of socioeconomic variables...
November 6, 2023: Current Opinion in Ophthalmology
https://read.qxmd.com/read/37916944/light-adjustable-intraocular-lenses-in-cataract-surgery-considerations
#34
JOURNAL ARTICLE
Jong Hwa Jun, Alexander Lieu, Natalie A Afshari
PURPOSE OF REVIEW: Light adjustable intraocular lens (LAL) is a promising concept in cataract surgery. This review explores considerations for the use of LALs. RECENT FINDINGS: Through updates, the safety of LALs and light delivery devices have been enhanced, enabling more efficient treatment with lower ultraviolet (UV) energy. Preoperative topography and aberration are essential for understanding indications for LALs. Furthermore, when determining intraocular lens power, it is crucial to factor in potential postoperative myopia or hyperopic adjustments...
November 3, 2023: Current Opinion in Ophthalmology
https://read.qxmd.com/read/37910173/future-directions-of-glaucoma-treatment-emerging-gene-neuroprotection-nanomedicine-stem-cell-and-vascular-therapies
#35
JOURNAL ARTICLE
Elizabeth C Ciociola, Elise Fernandez, Mary Kaufmann, Meredith R Klifto
PURPOSE OF REVIEW: The aim of this article is to summarize current research on novel gene, stem cell, neuroprotective, nanomedicine, and vascular therapies for glaucoma. RECENT FINDINGS: Gene therapy using viral vectors and siRNA have been shown to reduce intraocular pressure by altering outflow and production of aqueous humor, to reduce postsurgical fibrosis with few adverse effects, and to increase retinal ganglion cell (RGC) survival in animal studies. Stem cells may treat glaucoma by replacing or stimulating proliferation of trabecular meshwork cells, thus restoring outflow facility...
November 2, 2023: Current Opinion in Ophthalmology
https://read.qxmd.com/read/37910172/outcomes-and-predictive-factors-in-multifocal-and-extended-depth-of-focus-intraocular-lens-implantation
#36
JOURNAL ARTICLE
Matthew De la Paz, Linda M Tsai
PURPOSE OF REVIEW: Options for addressing presbyopia with intraocular lens (IOL) implantation have become more varied and sophisticated. We reviewed recent literature on multifocal and extended depth of focus (EDOF) IOLs in order to provide insight on their respective advantages, with emphasis on the visual outcomes of each design. RECENT FINDINGS: Increased patient age, spectral domain optical coherence tomography (SD-OCT) abnormalities, abnormal optical axis measurements, and better preoperative visual acuity have been implicated as predictors of worse postoperative vision or visual quality in multifocal IOLs...
November 2, 2023: Current Opinion in Ophthalmology
https://read.qxmd.com/read/37751544/editorial-introductions
#37
JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
November 1, 2023: Current Opinion in Ophthalmology
https://read.qxmd.com/read/37729665/anxiety-and-depression-in-patients-with-uveitis-a-comprehensive-review-of-observational-studies
#38
REVIEW
Charlene H Choo, John Gonzales, Jessica G Shantha
PURPOSE OF THE REVIEW: The purpose of this review is to provide a comprehensive summary of observational studies evaluating anxiety and depression in patients with uveitis. RECENT FINDINGS: A higher prevalence of depression was reported in patients with uveitis compared to healthy controls in most observational studies. Symptoms of anxiety were often, but not always, significantly worse in patients with uveitis compared to controls. Most studies found that patients with uveitis had reduced vision-related quality of life that was associated with anxiety and depression symptoms...
November 1, 2023: Current Opinion in Ophthalmology
https://read.qxmd.com/read/37729662/insights-into-spaceflight-associated-neuro-ocular-syndrome-with-review-of-intraocular-and-orbital-findings
#39
REVIEW
Dallin C Milner, Prem S Subramanian
PURPOSE OF REVIEW: Spaceflight-associated neuro-ocular syndrome (SANS) remains a phenomenological term, and advances in ophthalmic imaging as well as new insights from ground-based experiments have given support to new theories of how SANS develops and what may be done to counter it. RECENT FINDINGS: SANS has been postulated to arise from elevated intracranial pressure (ICP) during long-duration spaceflight (LDSF). However, recent work has shown that acute microgravity exposure does not increase ICP, and the effect of cephalad fluid shifts on ICP in microgravity remain unknown...
November 1, 2023: Current Opinion in Ophthalmology
https://read.qxmd.com/read/37729661/neuro-ophthalmic-manifestations-of-autoimmune-disorders-diagnostic-pearls-pitfalls
#40
REVIEW
Sabrina Poonja, Fiona Costello
PURPOSE OF REVIEW: The purpose of this review is to highlight a clinical-anatomical approach to localizing neuro-ophthalmic manifestations of associated autoimmune disorders. RECENT FINDINGS: Our understanding of autoimmune conditions has changed considerably over recent years, particularly with the emergence of novel autoantibodies. Cardinal neuro-ophthalmic signs and symptoms of antibody-mediated autoimmune disorders have been well characterized; knowledge thereof may be the first step towards an accurate diagnosis...
November 1, 2023: Current Opinion in Ophthalmology
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