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Journal of Cardiovascular Electrophysiology

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https://www.readbyqxmd.com/read/28321943/development-of-3d-intramural-and-surface-potentials-in-the-lv-microstructural-basis-of-preferential-transmural-conduction
#1
Bryan J Caldwell, Mark L Trew, Ian J Legrice, Bruce H Smaill
INTRODUCTION: Extracellular potentials measured on the heart surfaces are used to infer events that originate deep within the heart wall. We have reconstructed intramural potentials in three dimensions for the first time, and compare these with epicardial and endocardial surface potentials and cardiac microstructure. METHODS AND RESULTS: Extracellular potentials from intramural point stimulation were measured from a high density 3D electrode array in the in vivo pig LV...
March 21, 2017: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/28316148/ablation-of-complex-fractionated-electrograms-with-or-without-additional-linear-lesions-for-persistent-atrial-fibrillation-the-adline-trial
#2
Sonia Ammar-Busch, Felix Bourier, Tilko Reents, Verena Semmler, Marta Telishevska, Susanne Kathan, Monika Hofmann, Gabriele Hessling, Isabel Deisenhofer
BACKGROUND: For persistent atrial fibrillation (AF) ablation, different strategies including complex fractionated atrial electrograms (CFAE) ablation and linear lesions (LL) have been used in addition to pulmonary vein isolation (PVI). However, it is still a matter of debate if extended substrate modification improves long-term outcome. The aim of this study was to determine the benefit of LL in addition to PVI and CFAE ablation regarding freedom from arrhythmia recurrence in patients with persistent AF...
March 18, 2017: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/28316113/the-utility-of-exercise-testing-in-risk-stratification-of-asymptomatic-patients-with-type-1-brugada-pattern
#3
Muthiah Subramanian, Mukund A Prabhu, M S Harikrishnan, Saritha S Shekhar, Praveen G Pai, K U Natarajan
INTRODUCTION: Risk stratification of asymptomatic patients with a Brugada type 1 ECG pattern remains an unresolved clinical conundrum. In contrast to provocative pharmacological testing in Brugada syndrome, there is limited data on the role of exercise stress testing as a risk stratification modality. The objective of this study was to evaluate the utility of exercise testing in asymptomatic patients with type 1 Brugada pattern to prognosticate major arrhythmic events(MAE) during follow-up...
March 18, 2017: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/28316104/implantable-cardioverter-defibrillators-for-primary-prevention-of-mortality-in-patients-with-non-ischemic-cardiomyopathy-a-meta-analysis-of-randomized-controlled-trials
#4
Stavros Stavrakis, Zain Asad, Dwight Reynolds
BACKGROUND: Implantable cardioverter defibrillators (ICDs) improve survival in patients with heart failure due to ischemic cardiomyopathy, but their benefit in non-ischemic cardiomyopathy (NICM) has been recently questioned. We performed a meta-analysis of randomized clinical trials to examine the effect of ICDs on total mortality and arrhythmic death in patients with NICM. We also examined the impact of age and cardiac resynchronization therapy (CRT) on the relative effect of ICD compared to control...
March 18, 2017: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/28301685/conventional-versus-3d-echocardiography-to-predict-arrhythmia-recurrence-after-atrial-fibrillation-ablation
#5
Matthias Bossard, Sven Knecht, Stefanie Aeschbacher, Ronny R Buechel, Thomas Hochgruber, Andreas J Zimmermann, Arnheid Kessel-Schaefer, Frank-Peter Stephan, Gian Völlmin, Maurice Pradella, Christian Sticherling, Stefan Osswald, Beat A Kaufmann, David Conen, Michael Kühne
BACKGROUND: Arrhythmia recurrence after atrial fibrillation (AF) ablation remains high and requires repeat interventions in a substantial number of patients. We assessed the value of conventional and 3D-echocardiography to predict AF recurrence. METHODS AND RESULTS: Consecutive patients undergoing AF ablation by means of pulmonary vein isolation were included in a prospective registry. Echocardiograms were obtained prior to the ablation procedure, and analyzed offline in a standardized manner, including 3D-left atrial (LA) volumetry and determination of LA function and sphericity...
March 16, 2017: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/28297125/a-new-formula-for-estimating-the-true-qt-interval-in-left-bundle-branch-block
#6
Binhao Wang, L I Zhang, Peixin Cong, Huimin Chu, Ying Liu, Jinqiu Liu, William Surkis, Yunlong Xia
INTRODUCTION: QT prolongation is an independent risk factor for cardiac mortality. Left bundle branch block (LBBB) is more common in patients as they age. Widening of the QRS in LBBB causes false QT prolongation and thus makes true QT assessment difficult. We aimed to develop a simple formula to achieve a good estimate of the QT interval in the presence of LBBB. METHODS AND RESULTS: To determine the effect of QRS duration on the QT interval, QRS and QT were measured in sinus rhythm (SR) and during right ventricular apical pacing in 62 patients (age 55 ± 11 years, 60% male) undergoing electrophysiology studies...
March 15, 2017: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/28297123/embolization-of-watchman-device-following-a-hybrid-radiofrequency-ablation-of-atrial-fibrillation-and-watchman-implantation-procedure
#7
James Gabriels, Stuart Beldner, Mohammad Khan, Jonah Zeitlin, Ram Jadonath, Apoor Patel
A 24-year-old man with a history of type 1 diabetes mellitus, an ischemic left middle cerebral artery stroke and atrial flutter with a prior ablation was found to have paroxysmal atrial fibrillation (AF) on an implantable loop recorder. He was encouraged to continue anticoagulation with apixaban (CHA2 DS2 -VASc: 3). This article is protected by copyright. All rights reserved.
March 15, 2017: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/28257570/pattern-breaks-on-the-surface-ecg-can-we-anticipate-a-long-day-ahead
#8
EDITORIAL
Jason S Bradfield, Kalyanam Shivkumar
In 1988, Miller and colleagues(1) reported their experience with the correlation between 12-lead electrocardiograms (ECG) and endocardial sites of ventricular tachycardia (VT) origin in patients with coronary artery disease. In this series of 182 VTs in 108 patients, they noted numerous precordial transition patterns, one of which was a "regression/growth" pattern, with loss of R waves in the mid- precordial leads and then "regrowth" in the left precordial leads during right bundle branch block morphology VT...
March 3, 2017: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/28257569/hyperleptinemia-exacerbates-high-fat-diet-mediated-atrial-fibrosis-and-fibrillation
#9
Akira Fukui, Yuki Ikebe-Ebata, Hidekazu Kondo, Shotaro Saito, Kohei Aoki, Naoya Fukunaga, Tetsuji Shinohara, Takayuki Masaki, Yasushi Teshima, Naohiko Takahashi
BACKGROUND: Obesity including metabolic syndrome is an independent risk factor of atrial fibrillation (AF). Although hyperleptinemia is usually a characteristic of obese subjects, the relationship with atrial fibrosis and AF is unknown. We tested the hypothesis that high-fat diet (HFD)-induced hyperleptinemia exacerbates atrial fibrosis and AF. METHODS AND RESULTS: Eight-week-old male C57BL/6 (WT) and leptin-deficient ob/ob (Ob) mice were treated with a normal-fat diet (NFD) or 60% HFD...
March 3, 2017: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/28251724/temporal-trends-over-a-decade-of-defibrillator-therapy-for-primary-prevention-in-community-practice
#10
Serge Boveda, Kumar Narayanan, Sophie Jacob, Rui Providencia, Frankie Beganton, Vincent Algalarrondo, Pascal Defaye, Marie-Cécile Perier, Nicolas Sadoul, Olivier Piot, Didier Klug, Daniel Gras, Laurent Fauchier, Pierre Bordachar, Dominique Babuty, Jean-Claude Deharo, Christophe Leclercq, Eloi Marijon
BACKGROUND: Technology and clinical practice surrounding the use of the primary prevention implantable cardioverter defibrillator (ICD) are in a state of constant evolution. The purpose of the study was to test the hypothesis of significant temporal trends in characteristics and outcomes over a decade of ICD therapy. METHODS: Between 2002-2012, 5,539 consecutive patients (age 62.5±11 years, 84.9% male), with ischemic or non-ischemic cardiomyopathy, implanted with a primary prevention ICD from 12 centers in France were included...
March 2, 2017: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/28247974/combined-use-of-subcutaneous-icd-and-pacemakers-the-beginning-of-a-new-era
#11
EDITORIAL
Antonio Raviele, Antonio Rossillo
No abstract text is available yet for this article.
March 1, 2017: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/28245348/acute-cardiac-mri-assessment-of-radiofrequency-ablation-lesions-for-pediatric-ventricular-arrhythmia-feasibility-and-clinical-correlation
#12
Elena K Grant, Charles I Berul, Russell R Cross, Jeffrey P Moak, Karin S Hamann, Kohei Sumihara, Ileen Cronin, Kendall J O'Brien, Kanishka Ratnayaka, Michael S Hansen, Peter Kellman, Laura J Olivieri
BACKGROUND: Arrhythmia ablation with current techniques is not universally successful. Inadequate ablation lesion formation may be responsible for some arrhythmia recurrences. Peri-procedural visualization of ablation lesions may identify inadequate lesions and gaps to guide further ablation and reduce risk of arrhythmia recurrence. METHODS: This feasibility study assessed acute post-procedure ablation lesions by MRI, and correlated these findings with clinical outcomes...
February 28, 2017: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/28245342/assessment-of-the-extravascular-implantable-defibrillator-feasibility-of-substernal-ventricular-pacing
#13
Tom F Brouwer, Lonneke Smeding, Wouter R Berger, Antoine H G Driessen, Joris R de Groot, Arthur A M Wilde, Reinoud E Knops
INTRODUCTION: The objective of this study was to assess feasibility of ventricular pacing and thresholds from within the substernal space to examine a new extravascular ICD configuration with pacing capabilities. METHODS: In patients undergoing midline sternotomy, a duodecapolar diagnostic pacing catheter was positioned in the substernal space anterior to the pericardium, and a cutaneous patch in left lateral position. Different unipolar and bipolar pacing configurations were assessed...
February 28, 2017: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/28240435/ventricular-tachyarrhythmias-in-patients-with-hypertrophic-cardiomyopathy-and-defibrillators-triggers-treatment-and-implications
#14
Mark S Link, Katy Bockstall, Jonathan Weinstock, Alawi A Alsheikh-Ali, Christopher Semsarian, N A Mark Estes, Paolo Spirito, Tammy S Haas, Ethan J Rowin, Martin S Maron, Barry J Maron
INTRODUCTION: Triggers and ICD interventions of ventricular arrhythmias in patients with hypertrophic cardiomyopathy (HCM) offers insight into mechanisms and treatment. METHODS AND RESULTS: Intracardiac ICD electrograms from 71 HCM patients in the HCM I and II studies were analyzed by 3 individuals. Rhythms were defined as VF (polymorphic ventricular arrhythmia), VT (monomorphic ventricular tachycardia), and ventricular flutter (VFL) (VT ≥ 240 bpm). Physical activity and rhythm preceding the arrhythmia were ascertained...
February 27, 2017: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/28233951/outcomes-of-catheter-ablation-of-idiopathic-outflow-tract-ventricular-arrhythmias-with-an-r-wave-pattern-break-in-lead-v2-a-distinct-clinical-entity
#15
Tatsuya Hayashi, Pasquale Santangeli, Rajeev K Pathak, Daniele Muser, Jackson J Liang, Simon A Castro, Fermin C Garcia, Mathew D Hutchinson, Gregory E Supple, David S Frankel, Michael P Riley, David Lin, Robert D Schaller, Sanjay Dixit, David J Callans, Erica S Zado, Francis E Marchlinski
INTRODUCTION: In outflow tract ventricular arrhythmias (OT-VAs), an abrupt loss of the R wave in lead V2 compared to V1 and V3 (pattern break in V2-PBV2) suggests an origin close to the anterior interventricular sulcus (anatomically opposite to lead V2) and adjacent to proximal coronaries. We studied the outcome of catheter ablation of OT-VAs with a PBV2. METHODS AND RESULTS: Of 130 consecutive patients with idiopathic left bundle block morphology OT-VAs and transition ≤V4, 12 (9%) had PBV2...
February 24, 2017: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/28233925/focal-transcatheter-cryoablation-is-a-four-minute-application-still-required
#16
Francis Bessière, Marc Dubuc, Jason Andrade, Azadeh Shohoudi, Martin G Sirois, Blandine Mondésert, Katia Dyrda, Lena Rivard, Laurent Macle, Peter G Guerra, Bernard Thibault, Mario Talajic, Denis Roy, Paul Khairy
INTRODUCTION: The standard 4-minute application time for transcatheter cryoablation was determined in the 1990s when the system employed less potent chlorofluorocarbon refrigerants. The current refrigerant, nitrous oxide, generates substantially colder temperatures, with a faster cooling rate. METHODS AND RESULTS: We conducted a preclinical study on 32 mongrel dogs with stratified randomization of right atrial, right ventricular, and left ventricular chambers to 2-minute versus 4-minute application times using 8-mm electrode tip cryocatheters (Freezor Max, Medtronic CryoCath LP, Montreal, Canada)...
February 24, 2017: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/28218443/atrial-entrainment-during-posterior-fascicular-ventricular-tachycardia
#17
Krishna Kumar Mohanan Nair, Narayanan Namboodiri, Anees Thajudeen, Krishna Chaitanya, Sreevilasam Pushpangadhan Abhilash, Ajitkumar Valaparambil
A 20-year-old gentleman underwent electrophysiology study for paroxysmal palpitation. The surface electrocardiogram during sinus rhythm did not show any preexcitation. Echocardiogram was normal.  Basal intervals including AH and HV intervals were 115 ms and 42 ms, respectively. This article is protected by copyright. All rights reserved.
February 20, 2017: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/28211197/recurrences-in-the-blanking-period-and-12-month-success-rate-by-continuous-cardiac-monitoring-after-cryoablation-of-paroxysmal-and-non-paroxysmal-atrial-fibrillation
#18
Paolo Pieragnoli, Alessandro Paoletti Perini, Giuseppe Ricciardi, Luca Checchi, Andrea Giomi, Iacopo Muraca, Letizia Mannucci, Luigi Padeletti
INTRODUCTION: Recurrences within the blanking period (early recurrences) are common after atrial fibrillation (AF) ablation by pulmonary vein isolation (PVI), but their clinical significance is still controversial. We aimed at evaluating the significance of within-blanking recurrences at 12-month follow-up after cryoballoon (CB) PVI, and to assess the real procedural success rate by continuous monitoring of cardiac rhythm. METHODS AND RESULTS: Sixty consecutive AF patients (34 paroxysmal, 56...
February 17, 2017: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/28211133/an-unusual-short-rp-tachycardia-what-is-the-mechanism
#19
Joshua Balog
A 68-year-old man with a history of a structurally normal heart by echocardiography, an unsuccessful ablation of a narrow complex tachycardia and frequent symptoms of palpitations presents for an electrophysiology study and ablation. Baseline 12-lead EKG demonstrated sinus rhythm without ventricular preexcitation. This article is protected by copyright. All rights reserved.
February 17, 2017: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/28190278/surface-ecg-f-wave-analysis-at-initial-onset-of-paroxysmal-and-persistent-atrial-fibrillation
#20
Parth Sharma, Tyler W Barrett, Jason Ng, Claire Knoten, Allison J Ferreira, Jeffrey J Goldberger
INTRODUCTION: Dominant frequency (DF) analysis of electrocardiograms (ECGs) from patients with paroxysmal (PAF) and persistent (PeAF) atrial fibrillation has identified higher DFs in PeAF. We therefore hypothesized that among patients initially presenting to the emergency department (ED) with new onset AF, surface ECG features could differentiate PeAF from PAF. METHODS AND RESULTS: Initial 12-lead ECGs from patients presenting to the ED with a first episode of symptomatic AF were analyzed...
February 11, 2017: Journal of Cardiovascular Electrophysiology
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