journal
MENU ▼
Read by QxMD icon Read
search

Seminars in Cancer Biology

journal
https://www.readbyqxmd.com/read/30641125/metal-carcinogen-exposure-induces-cancer-stem-cell-like-property-through-epigenetic-reprograming-a-novel-mechanism-of-metal-carcinogenesis
#1
REVIEW
Zhishan Wang, Chengfeng Yang
Arsenic, cadmium, nickel and hexavalent chromium are among the most common environmental pollutants and potent carcinogens. Chronic exposure to these metals causes various types of cancer in humans, representing a significant environmental health issue. Although under active investigation, the mechanisms of metal carcinogenesis have not been clearly defined. One common feature of these metal carcinogens is that they are all able to cause various epigenetic dysregulations, which are believed to play important roles in their carcinogenicity...
January 11, 2019: Seminars in Cancer Biology
https://www.readbyqxmd.com/read/30633978/overview-of-the-oncogenic-signaling-pathways-in-colorectal-cancer-mechanistic-insights
#2
REVIEW
Ammad Ahmad Farooqi, Marc De La Roche, Mustafa Ba Djamgoz, Zahid H Siddik
Colorectal cancer is a multifaceted disease which is therapeutically challenging. Based on insights gleaned from almost a quarter century of research, it is obvious that deregulation of spatio-temporally controlled signaling pathways play instrumental role in development and progression of colorectal cancer. High-throughput technologies have helped to develop a sharper and broader understanding of the wide ranging signal transduction cascades which also contribute to development of drug resistance, loss of apoptosis and, ultimately, of metastasis...
January 8, 2019: Seminars in Cancer Biology
https://www.readbyqxmd.com/read/30550956/circrnas-and-cancer-biomarkers-and-master-regulators
#3
REVIEW
Esther Arnaiz, Carla Sole, Lorea Manterola, Leire Iparraguirre, David Otaegui, Charles H Lawrie
Circular RNAs (circRNAs) are a novel class of regulatory RNAs that despite being relatively abundant have only recently begun to be explored. There are many thousands of genes that appear capable of producing circRNAs, however the function of all but a handful remain to be determined. What is emerging about these highly conserved molecules is that they play important roles in biology and cancer biology in particular. The most explored function of circRNAs is as master regulators of gene expression that act to sequester or ´sponge´ other gene expression regulators, in particular miRNAs...
December 11, 2018: Seminars in Cancer Biology
https://www.readbyqxmd.com/read/30503852/special-issue-current-vision-on-target-enzymes-for-cancer-therapy
#4
EDITORIAL
Anupam Bishayee, Mohammad Amjad Kamal
No abstract text is available yet for this article.
November 29, 2018: Seminars in Cancer Biology
https://www.readbyqxmd.com/read/30502375/dna-replication-licensing-proteins-saints-and-sinners-in-cancer
#5
REVIEW
Muhammad Jameel Mughal, Ravikiran Mahadevappa, Hang Fai Kwok
DNA replication is all-or-none process in the cell, meaning, once the DNA replication begins it proceeds to completion. Hence, to achieve maximum control of DNA replication, eukaryotic cells employ a multi-subunit initiator protein complex known as "pre-replication complex or DNA replication licensing complex (DNA replication LC). This complex involves multiple proteins which are origin-recognition complex family proteins, cell division cycle-6, chromatin licensing and DNA replication factor 1, and minichromosome maintenance family proteins...
November 28, 2018: Seminars in Cancer Biology
https://www.readbyqxmd.com/read/30472212/dietary-phytochemicals-in-the-regulation-of-epithelial-to-mesenchymal-transition-and-associated-enzymes-a-promising-anticancer-therapeutic-approach
#6
REVIEW
Bornita Das, Sarkar Nivedita, Bishayee Anupam, Sinha Dona
Epithelial to mesenchymal transition (EMT) is a biological phenomenon that plays a primordial role for initiation of metastasis. It renders cancer cells with increased self-renewal and tumor-initiating capabilities and exacerbated resistance to apoptosis and chemotherapy. Hence, regulation of EMT stands out to be an important strategy in controlling the behavior of malignant cells. Despite the enormous amount of preclinical data on the implication of EMT in cancer progression, there is still lack of routine clinical translation at therapeutic levels...
November 22, 2018: Seminars in Cancer Biology
https://www.readbyqxmd.com/read/30458202/the-lonely-driver-or-the-orchestra-of-mutations-how-next-generation-sequencing-datasets-contradict-the-concept-of-single-driver-checkpoint-mutations-in-solid-tumours-nsclc-as-a-scholarly-example
#7
REVIEW
Verena Schildgen, Oliver Schildgen
Driver mutations are considered to be responsible for the majority of cancers and several of those mutations provide targets in order to set up personalized therapies. So far the generally accepted opinion had been that driver mutations occur as stand-alone factors, but novel sequencing technologies induced an essential rethink. Next generation sequencing approaches have shown that double, triple or multiple concurrent mutations could occur within the same tumour and may by interaction influence sensitivity to anticancer drugs and therapy success...
November 17, 2018: Seminars in Cancer Biology
https://www.readbyqxmd.com/read/30453042/establishing-a-role-for-environmental-toxicant-exposure-induced-epigenetic-remodeling-in-malignant-transformation
#8
REVIEW
Kristen M Humphrey, Sumali Pandey, Jeffery Martin, Tamara Hagoel, Anne Grand'Maison, Joyce E Ohm
Humans are exposed to a wide variety of environmental exposures throughout their lifespan. These include both naturally occurring toxins and chemical toxicants like pesticides, herbicides, and industrial chemicals, many of which have been implicated as possible contributors to human disease susceptibility [1-3]. We, and others, have hypothesized that environmental exposures may cause adaptive epigenetic changes in regenerative cell populations and developing organisms, leading to abnormal gene expression and increased disease susceptibility later in life [3]...
November 16, 2018: Seminars in Cancer Biology
https://www.readbyqxmd.com/read/30453041/the-multiverse-nature-of-epithelial-to-mesenchymal-transition
#9
REVIEW
Pasquale Simeone, Marco Trerotola, Julien Franck, Cardon Tristan, Marco Marchisio, Isabelle Fournier, Michel Salzet, Michele Maffia, Daniele Vergara
The epithelial mesenchymal transition (EMT) program is defined as a cellular transition from an epithelial to a mesenchymal state. This process occurs to provide the cell with new phenotypic assets and new skills to perform complex processes. EMT is regulated at multilayer levels, including transcriptional control of gene expression, regulation of RNA splicing, and translational/post-translational control. Although transcriptional regulation by EMT-inducing transcription factors (EMT-TFs), including Zeb, Snail and Slug members, is generally considered the master step in this process, several evidence indicates that all these regulatory networks may have a role in the control of EMT...
November 16, 2018: Seminars in Cancer Biology
https://www.readbyqxmd.com/read/30453040/the-role-of-sirtuins-family-in-cell-metabolism-during-tumor-development
#10
REVIEW
Shunqin Zhu, Zhen Dong, Xiaoxue Ke, Jianbing Hou, Erhu Zhao, Kui Zhang, Feng Wang, Liqun Yang, Zhonghuai Xiang, Hongjuan Cui
Altering energy metabolism to meet the uncontrolled proliferation and metastasis has emerged as one of the most significant hallmarks in tumors. However, the detailed molecular mechanisms and regulatory actions underlying has not been fully elucidated. As a family of NAD+ dependent protein modifying enzyme, sirtuins (SIRT1-SIRT7) have multiple catalytic functions such as deacetylase, desuccinylase, demalonylase, demyristoylase depalmitoylase, and/or mono-ADP-ribosyltransferase, and play important roles in regulating cell metabolism, especially in glucose and lipid metabolism, thereby exerting complex functions in either increasing or decreasing malignant characteristics in tumors...
November 16, 2018: Seminars in Cancer Biology
https://www.readbyqxmd.com/read/30448242/kdm5b-is-a-master-regulator-of-the-h3k4-methylome-in-stem-cells-development-and-cancer
#11
REVIEW
Besa Xhabija, Benjamin L Kidder
Epigenetic regulation of chromatin plays a critical role in controlling stem cell function and tumorigenesis. The histone lysine demethylase, KDM5B, which catalyzes the demethylation of histone 3 lysine 4 (H3K4), is important for embryonic stem (ES) cell differentiation, and is a critical regulator of the H3K4-methylome during early mouse embryonic pre-implantation stage development. KDM5B is also overexpressed, amplified, or mutated in many cancer types. In cancer cells, KDM5B regulates expression of oncogenes and tumor suppressors by modulating H3K4 methylation levels...
November 16, 2018: Seminars in Cancer Biology
https://www.readbyqxmd.com/read/30509407/special-issue-cancer-stem-cells-impact-on-treatment
#12
EDITORIAL
Ira Skvortsova
No abstract text is available yet for this article.
December 2018: Seminars in Cancer Biology
https://www.readbyqxmd.com/read/30471331/therapy-resistance-mediated-by-cancer-stem-cells
#13
REVIEW
Teresa Bernadette Steinbichler, József Dudás, Sergej Skvortsov, Ute Ganswindt, Herbert Riechelmann, Ira-Ida Skvortsova
Cancer stem cells (CSC) possess abilities generally associated with embryonic or adult stem cells, especially self-renewal and differentiation. The CSC model assumes that this subpopulation of cells sustains malignant growth, which suggests a hierarchical organization of tumors in which CSCs are on top and responsible for the generation of intratumoral heterogeneity. Effective tumor therapy requires the eradication of CSC as they can support regrowth of the tumor resulting in recurrence. However, eradication of CSC is difficult because they frequently are therapy resistant...
December 2018: Seminars in Cancer Biology
https://www.readbyqxmd.com/read/30317036/tumour-microenvironment-and-metabolic-plasticity-in-cancer-and-cancer-stem-cells-perspectives-on-metabolic-and-immune-regulatory-signatures-in-chemoresistant-ovarian-cancer-stem-cells
#14
REVIEW
Nuzhat Ahmed, Ruth Escalona, Dilys Leung, Emily Chan, George Kannourakis
Cancer stem cells (CSCs) are a sub-population of tumour cells, which are responsible to drive tumour growth, metastasis and therapy resistance. It has recently been proposed that enhanced glucose metabolism and immune evasion by tumour cells are linked, and are modulated by the changing tumour microenvironment (TME) that creates a competition for nutrient consumption between tumour and different sub-types of cells attracted to the TME. To facilitate efficient nutrient distribution, oncogene-induced inflammatory milieu in the tumours facilitate adaptive metabolic changes in the surrounding non-malignant cells to secrete metabolites that are used as alternative nutrient sources by the tumours to sustain its increasing energy needs for growth and anabolic functions...
October 11, 2018: Seminars in Cancer Biology
https://www.readbyqxmd.com/read/30317035/human-endogenous-retroviruses-role-in-cancer-cell-stemness
#15
REVIEW
Claudia Matteucci, Emanuela Balestrieri, Ayele Argaw-Denboba, Paola Sinibaldi-Vallebona
Cancer incidence and mortality, metastasis, drug resistance and recurrence are still the critical issues of oncological diseases. In this scenario, increasing scientific evidences demonstrate that the activation of human endogenous retroviruses (HERVs) is involved in the aggressiveness of tumors such as melanoma, breast, germ cell, renal, ovarian, liver and haematological cancers. In their dynamic regulation, HERVs have also proved to be important determinants of pluripotency in human embryonic stem cells (ESC) and of the reprogramming process of induced pluripotent stem cells (iPSCs)...
October 11, 2018: Seminars in Cancer Biology
https://www.readbyqxmd.com/read/30314681/small-molecule-tyrosine-kinase-inhibitors-and-pancreatic-cancer-trials-and-troubles
#16
REVIEW
Bhaskar Venkata Kameswara Subrahmanya Lakkakula, Batoul Farran, Saikrishna Lakkakula, Sujatha Peela, Nagendra Sastry Yarla, Pallaval Veera Bramhachari, Mohammad Amjad Kamal, Madhu Sudhana Saddala, Ganji Purnachandra Nagaraju
Pancreatic cancer (PC) is an aggressive carcinoma and the fourth cause of cancer deaths in Western countries. Although surgery is the most effective therapeutic option for PC, the management of unresectable, locally advanced disease is highly challenging. Our improved understanding of pancreatic tumor biology and associated pathways has led to the development of various treatment modalities that can control the metastatic spread of PC. This review intends to present trials of small molecule tyrosine kinase inhibitors (TKIs) in PC management and the troubles encountered due to inevitable acquired resistance to TKIs...
October 9, 2018: Seminars in Cancer Biology
https://www.readbyqxmd.com/read/30086389/in-the-beginning-there-was-chaos-a-perspective-on-the-development-of-immuno-oncological-biomarkers
#17
EDITORIAL
Roberto Salgado, Lyndsay Harris, Ira Skvortsova, Carsten Denkert, Sherene Loi
No abstract text is available yet for this article.
October 2018: Seminars in Cancer Biology
https://www.readbyqxmd.com/read/29990622/scoring-of-tumor-infiltrating-lymphocytes-from-visual-estimation-to-machine-learning
#18
REVIEW
F Klauschen, K-R Müller, A Binder, M Bockmayr, M Hägele, P Seegerer, S Wienert, G Pruneri, S de Maria, S Badve, S Michiels, T O Nielsen, S Adams, P Savas, F Symmans, S Willis, T Gruosso, M Park, B Haibe-Kains, B Gallas, A M Thompson, I Cree, C Sotiriou, C Solinas, M Preusser, S M Hewitt, D Rimm, G Viale, S Loi, S Loibl, R Salgado, C Denkert
The extent of tumor-infiltrating lymphocytes (TILs), along with immunomodulatory ligands, tumor-mutational burden and other biomarkers, has been demonstrated to be a marker of response to immune-checkpoint therapy in several cancers. Pathologists have therefore started to devise standardized visual approaches to quantify TILs for therapy prediction. However, despite successful standardization efforts visual TIL estimation is slow, with limited precision and lacks the ability to evaluate more complex properties such as TIL distribution patterns...
October 2018: Seminars in Cancer Biology
https://www.readbyqxmd.com/read/29935312/the-reciprocal-function-and-regulation-of-tumor-vessels-and-immune-cells-offers-new-therapeutic-opportunities-in-cancer
#19
REVIEW
Rindert Missiaen, Massimiliano Mazzone, Gabriele Bergers
Tumor angiogenesis and escape of immunosurveillance are two cancer hallmarks that are tightly linked and reciprocally regulated by paracrine signaling cues of cell constituents from both compartments. Formation and remodeling of new blood vessels in tumors is abnormal and facilitates immune evasion. In turn, immune cells in the tumor, specifically in context with an acidic and hypoxic environment, can promote neovascularization. Immunotherapy has emerged as a major therapeutic modality in cancer but is often hampered by the low influx of activated cytotoxic T-cells...
October 2018: Seminars in Cancer Biology
https://www.readbyqxmd.com/read/29857038/emerging-trends-in-biomarker-discovery-ease-of-prognosis-and-prediction-in-cancer
#20
EDITORIAL
Anil K Sharma
No abstract text is available yet for this article.
October 2018: Seminars in Cancer Biology
journal
journal
30484
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"