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Seminars in Cancer Biology

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https://www.readbyqxmd.com/read/30317036/tumour-microenvironment-and-metabolic-plasticity-in-cancer-and-cancer-stem-cells-perspectives-on-metabolic-and-immune-regulatory-signatures-in-chemoresistant-ovarian-cancer-stem-cells
#1
REVIEW
Nuzhat Ahmed, Ruth Escalona, Dilys Leung, Emily Chan, George Kannourakis
Cancer stem cells (CSCs) are a sub-population of tumour cells, which are responsible to drive tumour growth, metastasis and therapy resistance. It has recently been proposed that enhanced glucose metabolism and immune evasion by tumour cells are linked, and are modulated by the changing tumour microenvironment (TME) that creates a competition for nutrient consumption between tumour and different sub-types of cells attracted to the TME. To facilitate efficient nutrient distribution, oncogene-induced inflammatory milieu in the tumours facilitate adaptive metabolic changes in the surrounding non-malignant cells to secrete metabolites that are used as alternative nutrient sources by the tumours to sustain its increasing energy needs for growth and anabolic functions...
October 11, 2018: Seminars in Cancer Biology
https://www.readbyqxmd.com/read/30317035/human-endogenous-retroviruses-role-in-cancer-cell-stemness
#2
REVIEW
Claudia Matteucci, Emanuela Balestrieri, Ayele Argaw-Denboba, Paola Sinibaldi-Vallebona
Cancer incidence and mortality, metastasis, drug resistance and recurrence are still the critical issues of oncological diseases. In this scenario, increasing scientific evidences demonstrate that the activation of human endogenous retroviruses (HERVs) is involved in the aggressiveness of tumors such as melanoma, breast, germ cell, renal, ovarian, liver and haematological cancers. In their dynamic regulation, HERVs have also proved to be important determinants of pluripotency in human embryonic stem cells (ESC) and of the reprogramming process of induced pluripotent stem cells (iPSCs)...
October 11, 2018: Seminars in Cancer Biology
https://www.readbyqxmd.com/read/30314681/small-molecule-tyrosine-kinase-inhibitors-and-pancreatic-cancer-trials-and-troubles
#3
REVIEW
Bhaskar Venkata Kameswara Subrahmanya Lakkakula, Batoul Farran, Saikrishna Lakkakula, Sujatha Peela, Nagendra Sastry Yarla, Pallaval Veera Bramhachari, Mohammad Amjad Kamal, Madhu Sudhana Saddala, Ganji Purnachandra Nagaraju
Pancreatic cancer (PC) is an aggressive carcinoma and the fourth cause of cancer deaths in Western countries. Although surgery is the most effective therapeutic option for PC, the management of unresectable, locally advanced disease is highly challenging. Our improved understanding of pancreatic tumor biology and associated pathways has led to the development of various treatment modalities that can control the metastatic spread of PC. This review intends to present trials of small molecule tyrosine kinase inhibitors (TKIs) in PC management and the troubles encountered due to inevitable acquired resistance to TKIs...
October 9, 2018: Seminars in Cancer Biology
https://www.readbyqxmd.com/read/30273656/parallels-between-artificial-reprogramming-and-the-biogenesis-of-cancer-stem-cells-involvement-of-lncrnas
#4
REVIEW
Theodore P Rasmussen
Cellular identity is established and maintained by the interplay of cell type-specific transcription factors and epigenetic regulation of the genome. During development in vivo and differentiation in vitro, transitions from one cell type to the next are triggered by cell signaling events culminating in modifications of chromatin that render genes accessible or inaccessible to the transcriptional apparatus. In recent years it has become apparent that cellular identity is plastic, and technological reprogramming methods such as somatic cell nuclear transfer and induced pluripotency can yield reprogrammed cells that have been restored to a state of developmental potency...
September 28, 2018: Seminars in Cancer Biology
https://www.readbyqxmd.com/read/30273655/metabolism-and-epigenetics-of-pancreatic-cancer-stem-cells
#5
REVIEW
M Perusina Lanfranca, J K Thompson, F Bednar, C Halbrook, C Lyssiotis, B Levi, T L Frankel
Pancreatic Cancer (PDA) is an aggressive malignancy characterized by early spread and a high mortality. Current studies suggest that a subpopulation of cells exist within tumors, cancer stem cell (CSC), which are capable of self-renewal and give rise to unique progeny which form the major neoplastic cellular component of tumors. While CSCs constitute a small cellular subpopulation within the tumor, their resistance to chemotherapy and radiation make them an important therapeutic target for eradication. Along with distinctive phenotypic properties, CSCs possess a unique metabolic plasticity allowing them to rapidly respond and adapt to environmental changes...
September 28, 2018: Seminars in Cancer Biology
https://www.readbyqxmd.com/read/30268432/the-special-stemness-functions-of-tbx3-in-stem-cells-and-cancer-development
#6
REVIEW
Liang Dong, Xiaoming Lyu, Oluwasijibomi Damola Faleti, Ming-Liang He
The T-box factors belong to an ancient protein family, which comprises a cluster of evolutionarily-conserved transcription factors that regulate gene expression and that are crucial to embryonic development. T-box transcription factor 3 (Tbx3) is a member of this family, is expressed in some tissues, and is a key regulator in many critical organs, including the heart, mammary gland, and limbs. Overexpression of Tbx3 is associated with a number of cancers, including head and neck squamous cell carcinoma, gastric, breast, ovary, cervical, pancreatic, bladder and liver cancers, as well as melanoma...
September 27, 2018: Seminars in Cancer Biology
https://www.readbyqxmd.com/read/30266571/cellular-and-molecular-mechanisms-of-glioblastoma-malignancy-implications-in-resistance-and-therapeutic-strategies
#7
REVIEW
Joana Balça-Silva, Diana Matias, Anália do Carmo, Ana Bela Sarmento-Ribeiro, Maria Celeste Lopes, Vivaldo Moura-Neto
Glioblastoma (GBM) is the more frequent and malignant brain tumour. In spite of all efforts, the median overall survival of GBM patients remains approximately 15 months under therapy. The molecular biology underlying GBM is complex, which highlight the need of specific treatment strategies. In fact, the deregulation of several molecular signalling pathways, the existence of the blood-brain barrier, that makes almost all the chemotherapeutic agents inaccessible to the tumour site, and the existence of a population of stem-like cells known to be responsible for tumour recurrence after therapy, can contribute to GBM chemoresistance...
September 25, 2018: Seminars in Cancer Biology
https://www.readbyqxmd.com/read/30261277/deciphering-the-metabolic-role-of-ampk-in-cancer-multi-drug-resistance
#8
REVIEW
Wen Tan, Zhangfeng Zhong, Randy P Carney, Yongfan Men, Jiannan Li, Tingrui Pan, Yitao Wang
Multi-drug resistance (MDR) is a curious bottleneck in cancer research and chemotherapy, whereby some cells rapidly adapt to the tumor microenvironment via a myriad of heterogeneous metabolic activities. Despite being a major impediment to treatment, there is a silver lining: control over metabolic regulation could be an effective approach to overcome or correct resistance pathways. In this critical review, we comprehensively and carefully curated and analyzed large networks of previously identified proteins associated with metabolic adaptation in MDR...
September 24, 2018: Seminars in Cancer Biology
https://www.readbyqxmd.com/read/30261276/the-role-of-cancer-stem-cells-in-the-modulation-of-anti-tumor-immune-responses
#9
REVIEW
Cristina Maccalli, Kakil Ibrahim Rasul, Mamoun Elawad, Soldano Ferrone
Tumor lesions comprise multiple subpopulations of cells including those endowed with "stemness" properties. The latter cells are responsible of tumor initiation, metastasis formation, resistance to conventional therapies and disease recurrence. These relatively rare cells denominated cancer stem cells (CSCs) or cancer initiating cells (CICs) are defined based on self-renewing, multipotency and tumorigenicity. These cells through their immunomodulating features can evade from immunesurveillance, persisting in the form of quiescence and dormancy...
September 24, 2018: Seminars in Cancer Biology
https://www.readbyqxmd.com/read/30213689/new-developments-in-mechanisms-of-prostate-cancer-progression
#10
REVIEW
Nicholas Howard, Marco Clementino, Donghern Kim, Lei Wang, Angela Verma, Xianglin Shi, Zhuo Zhang, Robert S DiPaola
Prostate cancer is the most prevalent type of cancer in men. The etiology of prostate cancer development and the mechanisms underlying androgen-independent progression remains to be further investigated. There are many known targets for prostate cancer therapy including the androgen receptor (AR) axis, but resistance eventually develops in advanced disease suggesting the need to better understand mechanisms of resistance and consideration of multi-targeted therapy. Mechanisms contributing to resistance may include gene amplifications, gene mutations, AR splice variants, and changes in expression of androgen receptor co-regulatory proteins...
September 10, 2018: Seminars in Cancer Biology
https://www.readbyqxmd.com/read/30213688/an-epigenetic-perspective-on-tumorigenesis-loss-of-cell-identity-enhancer-switching-and-namirna-network
#11
REVIEW
Ying Liang, Peng Xu, Qingping Zou, Huaibing Luo, Wenqiang Yu
Various tumorigenic theories have been proposed in the past century, which contribute to the prevention and treatment of cancer clinically. However, the underlying mechanisms of the initiation of cancer, drug resistance, neoplasm relapse, and metastasis are still challenging to be panoramically addressed. Based on the abundant evidence provided by others and us, we postulate that Tumor Initiated by Loss of Cell Identity (LOCI), which is an inevitable initiating event of tumorigenesis. As a result, normal cells are transformed into the cancerous cell...
September 10, 2018: Seminars in Cancer Biology
https://www.readbyqxmd.com/read/30208341/an-epigenetic-perspective-on-tumorigenesis-loss-of-cell-identity-enhancer-switching-and-namirna-network
#12
REVIEW
Ying Liang, Peng Xu, Qingping Zou, Huaibing Luo, Wenqiang Yu
Various tumorigenic theories have been proposed in the past century, which contribute to the prevention and treatment of cancer clinically. However, the underlying mechanisms of the initiation of cancer, drug resistance, neoplasm relapse, and metastasis are still challenging to be panoramically addressed. Based on the abundant evidence provided by others and us, we postulate that Tumor Initiated by Loss of Cell Identity (LOCI), which is an inevitable initiating event of tumorigenesis. As a result, normal cells are transformed into the cancerous cell...
September 9, 2018: Seminars in Cancer Biology
https://www.readbyqxmd.com/read/30205139/epigenetic-modulation-of-metabolism-in-glioblastoma
#13
REVIEW
Zhen Dong, Hongjuan Cui
Epigenetic and metabolic alterations incancer cells are highly associated. Glioblastoma multiforme (GBM) is a complicated pathological process with dysregulated methylation and histone modifications. Metabolic modulation of epigenetics in gliomas was previously summarized. However, epigenetic modulation is also important in metabolic decision. Recently, there has been a tremendous increase in understanding of DNA methylation, chromatin modulation, and non-coding RNAs in the regulation of cell metabolism, especially glycolytic metabolism in GBM...
September 8, 2018: Seminars in Cancer Biology
https://www.readbyqxmd.com/read/30189250/targeting-the-paracrine-hormone-dependent-guanylate-cyclase-cgmp-phosphodiesterases-signaling-pathway-for-colorectal-cancer-prevention
#14
REVIEW
N S Yarla, H Gali, G Pathuri, S Smriti, M Farooqui, J Panneerselvam, G Kumar, V Madka, C V Rao
Colorectal cancer (CRC) is one of the leading causes of cancer related-deaths. The risk of development of CRC is complex and multifactorial, and includes disruption of homeostasis of the intestinal epithelial layer mediated though dysregulations of tumor suppressing/promoting signaling pathways. Guanylate cyclase 2C (GUCY2C), a membrane-bound guanylate cyclase receptor, is present in the apical membranes of intestinal epithelial cells and maintains homeostasis. GUCY2C is activated upon binding of paracrine hormones (guanylin and uroguanylin) that lead to formation of cyclic GMP from GTP and activation of downstream signaling pathways that are associated with normal homeostasis...
September 3, 2018: Seminars in Cancer Biology
https://www.readbyqxmd.com/read/30171980/cancer-testis-antigens-unique-cancer-stem-cell-biomarkers-and-targets-for-cancer-therapy
#15
REVIEW
Olga Gordeeva
Cancer-testis antigens (CTAs) are considered as unique and promising cancer biomarkers and targets for cancer therapy. CTAs are multifunctional protein group with specific expression patterns in normal embryonic and adult cells and various types of cancer cells. CTAs are involved in regulating of the basic cellular processes during development, stem cell differentiation and carcinogenesis though the biological roles and cell functions of CTA families remain largely unclear. Analysis of CTA expression patterns in embryonic germ and somatic cells, pluripotent and multipotent stem cells, cancer stem cells and their cell descendants indicates that rearrangements of characteristic CTA profiles (aberrant expression) could be associated with cancer transformation and failure of the developmental program of cell lineage specification and germ line restriction...
August 29, 2018: Seminars in Cancer Biology
https://www.readbyqxmd.com/read/30149066/oxidative-stress-modulating-drugs-have-preferential-anticancer-effects-involving-the-regulation-of-apoptosis-dna-damage-endoplasmic-reticulum-stress-autophagy-metabolism-and-migration
#16
REVIEW
Jen-Yang Tang, Ammad Ahmad Farooqi, Fu Ou-Yang, Ming-Feng Hou, Hurng-Wern Huang, Hui-Ru Wang, Kun-Tzu Li, Sundas Fayyaz, Chih-Wen Shu, Hsueh-Wei Chang
To achieve preferential effects against cancer cells but less damage to normal cells is one of the main challenges of cancer research. In this review, we explore the roles and relationships of oxidative stress-mediated apoptosis, DNA damage, ER stress, autophagy, metabolism, and migration of ROS-modulating anticancer drugs. Understanding preferential anticancer effects in more detail will improve chemotherapeutic approaches that are based on ROS-modulating drugs in cancer treatments.
August 24, 2018: Seminars in Cancer Biology
https://www.readbyqxmd.com/read/30130664/pancreatic-cancer-stem-cells-a-state-or-an-entity
#17
REVIEW
Patrick C Hermann, Bruno Sainz
Pancreatic ductal adenocarcinoma (PDAC), the most common type of pancreatic cancer, has a median overall survival of 6-12 months and a 5-year survival of less than 7%. While PDAC currently represents the 4th most frequent cause of death due to cancer worldwide, it is expected to become the second leading cause of cancer-related death by 2030. These alarming statistics are primarily due to both the inherent chemoresistant and metastatic nature of this tumor, and the existence of a subpopulation of highly plastic "stem"-like cells within the tumor, known as cancer stem cells (CSCs)...
August 18, 2018: Seminars in Cancer Biology
https://www.readbyqxmd.com/read/30130663/cancer-cell-plasticity-impact-on-tumor-progression-and-therapy-response
#18
REVIEW
Victoria da Silva-Diz, Laura Lorenzo-Sanz, Adrià Bernat-Peguera, Marta Lopez-Cerda, Purificación Muñoz
Most tumors exhibit intra-tumor heterogeneity, which is associated with disease progression and an impaired response to therapy. Cancer cell plasticity has been proposed as being an important mechanism that, along with genetic and epigenetic alterations, promotes cancer cell diversity and contributes to intra-tumor heterogeneity. Plasticity endows cancer cells with the capacity to shift dynamically between a differentiated state, with limited tumorigenic potential, and an undifferentiated or cancer stem-like cell (CSC) state, which is responsible for long-term tumor growth...
August 18, 2018: Seminars in Cancer Biology
https://www.readbyqxmd.com/read/30130662/current-understanding-and-clinical-utility-of-mirnas-regulation-of-colon-cancer-stem-cells
#19
REVIEW
Mariangela De Robertis, Maria Luana Poeta, Emanuela Signori, Vito Michele Fazio
Cancer stem cells (CSCs) in colorectal tumorigenesis are suggested to be responsible for initiation, development and propagation of colorectal cancer (CRC) and have been extensively characterized by the expression of phenotypic determinants, such as surface or intracellular proteins. The generation of CSCs is likely due to a dysregulation of the signaling pathways that principally control self-renewal and pluripotency in normal intestinal stem cells (ISCs) through different (epi)genetic changes that define cell fate, identity, and phenotype of CSCs...
August 18, 2018: Seminars in Cancer Biology
https://www.readbyqxmd.com/read/30086389/in-the-beginning-there-was-chaos-a-perspective-on-the-development-of-immuno-oncological-biomarkers
#20
EDITORIAL
Roberto Salgado, Lyndsay Harris, Ira Skvortsova, Carsten Denkert, Sherene Loi
No abstract text is available yet for this article.
October 2018: Seminars in Cancer Biology
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