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Journal of Nutritional Biochemistry

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https://www.readbyqxmd.com/read/29331881/ameliorative-role-of-genistein-against-age-dependent-chronic-arsenic-toxicity-in-murine-brains-via-the-regulation-of-oxidative-stress-and-inflammatory-signaling-cascades
#1
Sukanya Saha, Pritam Sadhukhan, Sushweta Mahalanobish, Sayanta Dutta, Parames C Sil
Brain is highly prone to oxidative damage due to its huge lipid content and extensive energy requirements. Exogenous insult in brain via oxidative injury can lead to severe pathophysiological conditions. Age-dependent deterioration of normal brain functions is also noteworthy. Genistein, a polyphenolic isoflavonoid, obtained from the soy plant, is well known to protect against several diseased conditions. Here, in this study chronic brain toxicity model was developed using oral administration of arsenic for 90 days in adult and aged murines...
December 12, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/29331869/dietary-naringenin-supplementation-attenuates-experimental-autoimmune-encephalomyelitis-by-modulating-autoimmune-inflammatory-responses-in-mice
#2
Junpeng Wang, Ying Qi, Xinli Niu, Hua Tang, Simin Nikbin Meydani, Dayong Wu
Autoimmune disease is highly prevalent in humans. Since conventional therapies have limited efficacy and often come with significant side effects, nutrition may provide an alternative and complementary approach to improving autoimmune disorders. Naringenin, a flavonoid found in citrus fruits, has been shown to have anti-inflammatory and antioxidant properties. Using the experimental autoimmune encephalomyelitis (EAE), a rodent model of human multiple sclerosis, we determined the effect of dietary naringenin (0...
December 11, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/29331868/zinc-supplementation-alleviates-the-progression-of-diabetic-nephropathy-by-inhibiting-the-overexpression-of-oxidative-stress-mediated-molecular-markers-in-streptozotocin-induced-experimental-rats
#3
Susmita Barman, Seetur R Pradeep, Krishnapura Srinivasan
Zinc deficiency during diabetes projects a role for zinc nutrition in the management of diabetic nephropathy. The current study explored whether zinc supplementation protects against diabetic nephropathy through modulation of kidney oxidative stress and stress-induced expression related to the inflammatory process in streptozotocin-induced diabetic rats. Groups of hyperglycemic rats were exposed to dietary interventions for 6 weeks with zinc supplementation (5 times and 10 times the normal level). Supplemental-zinc-fed diabetic groups showed a significant reversal of increased kidney weight and creatinine clearance...
December 11, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/29331496/maternal-betaine-supplementation-attenuates-glucocorticoid-induced-hepatic-lipid-accumulation-through-epigenetic-modification-in-adult-offspring-rats
#4
Nannan Zhao, Shu Yang, Yimin Jia, Bo Sun, Bin He, Ruqian Zhao
There are lots of reports about alleviation of NAFLD by dietary supplements of betaine. However, it remains unclear whether maternal betaine supplementation can also ameliorate NAFLD in offspring. Hence, twenty pregnant rats were fed with a basal diet with or without betaine (1%), and then the female offspring rats were raised at 3 months of age followed by 3 weeks of physiological saline or dexamethasone in a dose of 0.1 mg/kg body mass every day via intraperitoneal injection. In this study, maternal betaine supplementation significantly (P<...
December 11, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/29331880/preventive-effects-of-indole-3-carbinol-against-alcohol-induced-liver-injury-in-mice-via-antioxidant-anti-inflammatory-and-anti-apoptotic-mechanisms-role-of-gut-liver-adipose-tissue-axis
#5
Youngshim Choi, Mohamed A Abdelmegeed, Byoung-Joon Song
Indole-3-carbinol (I3C), found in Brassica family vegetables, exhibits antioxidant, anti-inflammatory, and anti-cancerous properties. Here, we aimed to evaluate the preventive effects of I3C against ethanol (EtOH)-induced liver injury and study the protective mechanism(s) by using the well-established chronic-plus-binge alcohol exposure model. The preventive effects of I3C were evaluated by conducting various histological, biochemical, and real-time PCR analyses in mouse liver, adipose tissue, and colon, since functional alterations of adipose tissue and intestine can also participate in promoting EtOH-induced liver damage...
December 10, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/29331497/dietary-antioxidant-micronutrients-alter-mucosal-inflammatory-risk-in-a-murine-model-of-genetic-and-microbial-susceptibility
#6
Joseph F Pierre, Reinhard Hinterleitner, Romain Bouziat, Nathan A Hubert, Vanessa Leone, Jun Miyoshi, Bana Jabri, Eugene B Chang
Inflammatory bowel diseases (IBD) are caused by the convergence of microbial, environmental, and genetic factors. Diet significantly alters these interactions by affecting both the host and microbiome. Using a mucosal inflammatory model that resembles the human condition of ileal pouchitis, we investigated the effects of Control (CONT) or Antioxidant (AOX) diet, containing pharmacologically relevant levels of 4 micronutrients, on disease risk in wild-type and IL-10-/- animals following surgical self-filling (SF) ileal blind loop placement...
December 10, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/29202273/effects-of-barley-variety-dietary-fiber-and-%C3%AE-glucan-content-on-bile-acid-composition-in-cecum-of-rats-fed-low-and-high-fat-diets
#7
Tannaz Ghaffarzadegan, Yadong Zhong, Frida Fåk Hållenius, Margareta Nyman
Diet-induced obesity and insulin resistance have been linked to changes in bile acid (BA) profiles, which in turn are highly dependent on the dietary composition and activity of the gut microbiota. The objective of the present study was to investigate whether the type and level of fiber had an effect on cecal BA composition when included in low- and high-fat diets. Groups of rats were fed two barley varieties, which resulted in three test diets containing three levels of β-glucans and two levels of dietary fiber...
December 1, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/29195132/lycopene-mitigates-%C3%AE-amyloid-induced-inflammatory-response-and-inhibits-nf-%C3%AE%C2%BAb-signaling-at-the-choroid-plexus-in-early-stages-of-alzheimer-s-disease-rats
#8
Chong-Bin Liu, Rui Wang, Yan-Feng Yi, Zhen Gao, Yi-Zhu Chen
The choroid plexus is able to modulate the cognitive function, through changes in the neuroinflammatory response and in brain immune surveillance. However, whether lycopene is involved in inflammatory responses at the choroid plexus in the early stages of Alzheimer's disease, and its molecular underpinnings are elusive. In this rat study, lycopene was used to investigate its protective effects on inflammation caused by β-amyloid. We characterized the learning and memory abilities, cytokine profiles of circulating TNF-α, IL-1β and IL-6β in the serum and the expressions of Toll like receptor 4 and nuclear factor-κB p65 mRNA and protein at the choroid plexus...
November 28, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/29190549/cholesterol-oversynthesis-markers-define-familial-combined-hyperlipidemia-versus-other-genetic-hypercholesterolemias-independently-of-body-weight
#9
Lucía Baila-Rueda, Ana Cenarro, Itziar Lamiquiz-Moneo, Sofía Perez-Calahorra, Ana M Bea, Victoria Marco-Benedí, Estíbaliz Jarauta, Rocío Mateo-Gallego, Fernando Civeira
Primary hypercholesterolemia of genetic origin, negative for mutations in LDLR, APOB, PCSK9 and APOE genes (non-FH GH), and familial combined hyperlipidemia (FCHL) are polygenic genetic diseases that occur with hypercholesterolemia, and both share a very high cardiovascular risk. In order to better characterize the metabolic abnormalities associated with these primary hypercholesterolemias, we used noncholesterol sterols, as markers of cholesterol metabolism, to determine their potential differences. Hepatic cholesterol synthesis markers (desmosterol and lanosterol) and intestinal cholesterol absorption markers (sitosterol and campesterol) were determined in non-FH GH (n=200), FCHL (n=100) and genetically defined heterozygous familial hypercholesterolemia subjects (FH) (n=100) and in normolipidemic controls (n=100)...
November 27, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/29190548/supplementation-with-polyunsaturated-fatty-acids-in-pregnant-rats-with-mild-diabetes-normalizes-placental-ppar%C3%AE-and-mtor-signaling-in-female-offspring-developing-gestational-diabetes
#10
Evangelina Capobianco, Daiana Fornes, Sabrina Lorena Roberti, Theresa L Powell, Thomas Jansson, Alicia Jawerbaum
Maternal diabetes impairs fetoplacental development and programs metabolic diseases in the offspring. We have previously reported that female offspring of pregnant rats with mild diabetes develop gestational diabetes mellitus (GDM) when they become pregnant. Here, we studied the effects of supplementation with polyunsaturated fatty acids (PUFAs) in pregnant mild diabetic rats (F0) by feeding a 6% safflower-oil-enriched diet from day 1 to 14 followed by a 6% chia-oil-enriched diet from day 14 of pregnancy to term...
November 27, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/29329013/antiobesity-effect-of-lactobacillus-reuteri-263-associated-with-energy-metabolism-remodeling-of-white-adipose-tissue-in-high-energy-diet-fed-rats
#11
Li-Han Chen, Yi-Hsing Chen, Kuan-Chen Cheng, Ting-Yi Chien, Ching-Hung Chan, Shu-Ping Tsao, Hui-Yu Huang
Obesity is a serious and costly issue to the medical welfare worldwide. Probiotics have been suggested as one of the candidates to resolve the obesity-associated problems, but how they combat obesity is not fully understood. Herein, we investigated the effects of Lactobacillus reuteri 263 (L. reuteri 263) on antiobesity using four groups of Sprague-Dawley rats (n=10/group), namely, C (normal diet with vehicle treatment), HE [high-energy diet (HED) with vehicle treatment], 1X (HED with 2.1×109 CFU/kg/day of L...
November 16, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/29268106/food-components-with-antifibrotic-activity-and-implications-in-prevention-of-liver-disease
#12
REVIEW
Minkyung Bae, Young-Ki Park, Ji-Young Lee
Increasing prevalence of nonalcoholic fatty liver disease (NAFLD) in parallel with the obesity epidemic has been a major public health concern. NAFLD is the most common chronic liver disease in the United States, ranging from fatty liver to steatohepatitis, fibrosis and cirrhosis in the liver. In response to chronic liver injury, fibrogenesis in the liver occurs as a protective response; however, prolonged and dysregulated fibrogenesis can lead to liver fibrosis, which can further progress to cirrhosis and eventually hepatocellular carcinoma...
November 16, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/29257986/selective-enrichment-of-n-3-fatty-acids-in-human-plasma-lipid-motifs-following-intake-of-marine-fish
#13
Petr Žáček, Michael Bukowski, LuAnn Johnson, Susan K Raatz, Matthew Picklo
Plasma levels of n-3 long chain polyunsaturated fatty acids (LCPUFA) are associated with a reduction in risk of cardiovascular disease and other chronic, age-related diseases like Alzheimer's disease. In this work, we tested the hypothesis that n-3 LCPUFA fatty acids in human plasma are incorporated into selective lipid species following intake of n-3 LCPUFA rich marine fish. To test this hypothesis, we performed lipidomic analysis on plasma samples from a clinical trial in which participants consumed increasing amounts of farmed Atlantic salmon (Salmo salar)...
November 16, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/29242172/curcumin-enhances-lxr%C3%AE-in-an-amp-activated-protein-kinase-dependent-manner-in-human-macrophages
#14
Javier Sáenz, Gonzalo Alba, María E Reyes-Quiroz, Isabel Geniz, Juan Jiménez, Francisco Sobrino, Consuelo Santa-María
Liver X receptor alpha (LXRα) is a nuclear receptor involved in cholesterol homeostasis. Curcumin, a traditional Chinese derivative from the rhizomes of Curcuma longa and a well-known AMP-activated protein kinase (AMPK) activator, possess hypocholesterolemic activity, however, the possible link between AMPK and cholesterol is unknown. In this study, we have investigated whether curcumin regulates metabolic changes in cholesterol metabolism via LXRα in THP-1 human macrophages, the cells implicated in atheroma plaques formation...
November 16, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/29242171/down-regulation-of-stearoyl-coa-desaturase-1-increases-susceptibility-to-palmitic-acid-induced-lipotoxicity-in-human-trophoblast-cells
#15
Changwon Yang, Whasun Lim, Fuller W Bazer, Gwonhwa Song
In early pregnancy, adequate dietary factors are important for the growth of human trophoblast cells, followed by placental development. Although stearoyl-CoA desaturase 1 (SCD1) is expected to relieve palmitic acid (PA)-induced lipotoxicity by regulating diacylglycerol and ceramide, its function is unclear in human trophoblast cells. The aim was to investigate inhibitory effects of SCD1 activity on PA-induced trophoblast cell death. PA induces cell death and inhibits the invasion of human trophoblast cells (HTR8/SVneo)...
November 16, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/29223827/colonic-aberrant-crypt-formation-accompanies-an-increase-of-opportunistic-pathogenic-bacteria-in-c57bl-6-mice-fed-a-high-fat-diet
#16
Huawei Zeng, Suzanne L Ishaq, Zhenhua Liu, Michael R Bukowski
The increasing worldwide incidence of colon cancer has been linked to obesity and consumption of a high-fat Western diet. To test the hypothesis that a high-fat diet (HFD) promotes colonic aberrant crypt (AC) formation in a manner associated with gut bacterial dysbiosis, we examined the susceptibility to azoxymethane (AOM)-induced colonic AC and microbiome composition in C57/BL6 mice fed a modified AIN93G diet (AIN, 16% fat, energy) or an HFD (45% fat, energy) for 14 weeks. Mice receiving the HFD exhibited increased plasma leptin, body weight, body fat composition and inflammatory cell infiltration in the ileum compared with those in the AIN group...
November 10, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/29227833/vitamin-a-deficiency-in-mice-alters-host-and-gut-microbial-metabolism-leading-to-altered-energy-homeostasis
#17
Yuan Tian, Robert G Nichols, Jingwei Cai, Andrew D Patterson, Margherita T Cantorna
Vitamin A deficiency (A-) is a worldwide public health problem. To better understand how vitamin A status influences gut microbiota and host metabolism, we systematically analyzed urine, cecum, serum and liver samples from vitamin A sufficient (A+) and deficient (A-) mice using 1H NMR-based metabolomics, quantitative (q)PCR and 16S rRNA gene sequencing coupled with multivariate data analysis. The microbiota in the cecum of A- mice showed compositional as well as functional shifts compared to the microbiota from A+ mice...
November 5, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/29216605/gluten-peptides-drive-healthy-and-celiac-monocytes-toward-an-m2-like-polarization
#18
Amelia Barilli, Federica Gaiani, Barbara Prandi, Martina Cirlini, Filippo Ingoglia, Rossana Visigalli, Bianca Maria Rotoli, Nicola de'Angelis, Stefano Sforza, Gian Luigi de'Angelis, Valeria Dall'Asta
Celiac disease (CD) is an immune-mediated enteropathy triggered by ingested gluten in genetically susceptible individuals and sustained by both adaptive and innate immune responses. Recent studies in murine macrophages demonstrated that the activation of arginase (ARG) metabolic pathway by gluten peptides contributes to the modulation of intestinal permeability in vitro. Here we characterize the effects of gluten on arginine metabolism and cell polarization in human monocytes from both healthy and CD subjects; both a simplified enzymatic digestion of gliadin and a physiological digestion of whole wheat have been tested...
November 5, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/29197723/the-flavonoid-quercetin-inhibits-titanium-dioxide-tio2-induced-chronic-arthritis-in-mice
#19
Sergio M Borghi, Sandra S Mizokami, Felipe A Pinho-Ribeiro, Victor Fattori, Jefferson Crespigio, Juliana T Clemente-Napimoga, Marcelo H Napimoga, Dimitrius L Pitol, João P M Issa, Sandra Y Fukada, Rubia Casagrande, Waldiceu A Verri
Titanium dioxide (TiO2) is a common component of orthopedic prosthesis. However, prosthesis wear releases TiO2, which induces inflammation and osteolysis in peri-prosthetic tissues. Quercetin is a flavonoid widely present in human diet, which presents biological activities such as antinociceptive, anti-inflammatory and antioxidant effects. Therefore, the effect of intraperitoneal treatment with quercetin in TiO2-induced arthritis model was evaluated. In the first set of experiments, mice received injection of TiO2 (0...
November 5, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/29268122/resveratrol-and-pinostilbene-confer-neuroprotection-against-aging-related-deficits-through-an-erk1-2-dependent-mechanism
#20
Erika N Allen, Sneha Potdar, Victor Tapias, Mayur Parmar, Cassia S Mizuno, Agnes Rimando, Jane E Cavanaugh
Age-related declines in motor function may be due, in part, to an increase in oxidative stress in the aging brain leading to dopamine (DA) neuronal cell death. In this study, we examined the neuroprotective effects of natural antioxidants resveratrol and pinostilbene against age-related DAergic cell death and motor dysfunction using SH-SY5Y neuroblastoma cells and young, middle-aged, and old male C57BL/6 mice. Resveratrol and pinostilbene protected SH-SY5Y cells from a DA-induced decrease in cell viability...
November 4, 2017: Journal of Nutritional Biochemistry
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