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Journal of Nutritional Biochemistry

Noelia L Vanden Braber, Ivanna Novotny Nuñez, Luciana Bohl, Carina Porporatto, F Nicolás Nazar, Mariana A Montenegro, Silvia G Correa
We used water-soluble Chitosan obtained by Maillard reaction with glucosamine to microencapsulate soy genistein (Ge) and preserve its biological activity for oral administration. Release of Ge was pH dependent with a super Case II mechanism at pH 1.2 and an anomalous transport with non-Fickian kinetics at pH 6.8. Microencapsulated Ge retained its antioxidant properties in vitro and its daily administration to mice attenuated clinical signs of acute colitis, limited inflammatory reaction and reduced oxidative stress and tissue injury as well...
September 1, 2018: Journal of Nutritional Biochemistry
Silvia Rodrigo, Elena Fauste, Maite de la Cuesta, Lourdes Rodríguez, Juan J Álvarez-Millán, María I Panadero, Paola Otero, Carlos Bocos
Fructose consumption from added sugars correlates with the epidemic rise in obesity, metabolic syndrome and cardiovascular diseases. However, consumption of beverages containing fructose is allowed during gestation. We have investigated whether maternal fructose intake produces subsequent changes in cholesterol metabolism of progeny. Carbohydrates were supplied to pregnant rats in drinking water (10% w/v solution) throughout gestation. Adult male and female descendants from fructose-fed, control or glucose-fed mothers were studied...
September 1, 2018: Journal of Nutritional Biochemistry
Xiaoling Chen, Yafei Guo, Gang Jia, Guangmang Liu, Hua Zhao, Zhiqing Huang
This study investigated the effect of arginine on skeletal muscle fiber type transformation in mice and in C2C12 myotubes. Our data showed that dietary supplementation of arginine in mice significantly up-regulated the slow myosin heavy chain (MyHC), troponin I-SS, sirtuin1 (Sirt1) and peroxisome proliferator activated receptor-γ coactivator-1α (PGC-1α) protein expressions, as well as significantly down-regulated the fast MyHC protein expression. In C2C12 myotubes, arginine significantly increased the protein level of slow MyHC and the number of slow MyHC-positive cells, as well as significantly decreased the protein level of fast MyHC and the number of fast MyHC-positive cells...
September 1, 2018: Journal of Nutritional Biochemistry
Alba Rodríguez-Nogales, Francesca Algieri, José Garrido-Mesa, Teresa Vezza, M Pilar Utrilla, Natalia Chueca, Federico García, M Elena Rodríguez-Cabezas, Julio Gálvez
The beneficial effects exerted by probiotics in inflammatory bowel disease (IBD) are well known, although their exact mechanisms have not been fully elucidated, and only few studies have focused on their impact on selected miRNAs and the gut microbiota composition. Therefore, our aim was to correlate the intestinal anti-inflammatory activity of the probiotic Saccharomyces boulardii in the dextran sodium sulphate (DSS) model of mouse colitis and the changes induced in miRNA expression and gut microbiota populations...
September 1, 2018: Journal of Nutritional Biochemistry
Shigeru Hiramoto, Nobuhiro Yahata, Kanae Saitoh, Tomohiro Yoshimura, Yao Wang, Shigeto Taniyama, Takeshi Nikawa, Katsuyasu Tachibana, Katsuya Hirasaka
It has been reported that phytoextracts that contain alkylresorcinols (ARs) protect against severe myofibrillar degeneration found in isoproterenol-induced myocardial infarction. In this study, we examined the effect of dietary ARs derived from wheat bran extracts on muscle atrophy in denervated mice. The mice were divided into the following four groups: (1) sham-operated (control) mice fed with normal diet (S-ND), (2) denervated mice fed with normal diet (D-ND), (3) control mice fed with ARs-supplemented diet (S-AR) and (4) denervated mice fed with ARs-supplemented diet (D-AR)...
August 31, 2018: Journal of Nutritional Biochemistry
Katherine Gil-Cardoso, Iris Ginés, Montserrat Pinent, Anna Ardévol, Mayte Blay, Ximena Terra
The consumption of Westernized diets leads to hyperphagia and obesity, as well as intestinal alterations. In the present study, we evaluated the effect of the administration of a grape seed proanthocyanidin extract (GSPE) at different time points on the modulation of intestinal barrier function (intestinal permeability and metabolic endotoxemia), in rats with high-fat/high-carbohydrate diet-induced obesity. Animals were fed a cafeteria diet (CAF) supplemented with a preventive (PRE-CAF) or simultaneously intermittent (SIT-CAF) GSPE treatment (500 mg/kg bw)...
August 30, 2018: Journal of Nutritional Biochemistry
Sabrina Eliana Gambaro, María Guillermina Zubiría, Andrea Estefanía Portales, María Amanda Rey, Martín Rumbo, Andrés Giovambattista
Fructose-rich diet (FRD) has been associated with obesity development, which is characterized by adipocytes hypertrophy and chronic low-grade inflammation. Interaction of adipocytes and immune cells plays a key role in adipose tissue (AT) alterations in obesity. We assessed the metabolic and immune impairments in AT in a murine obesity model induced by FRD at different periods. Adult Swiss mice were divided into groups of 6 and 10 weeks of fructose (FRD 6wk, FRD 10wk) or water intake (CTR 6wk, CTR 10wk). FRD induced increased in body weight, epidydimal AT mass, and plasmatic and liver Tg, and impaired insulin sensitivity...
August 21, 2018: Journal of Nutritional Biochemistry
Maxim Verboven, Dorien Deluyker, Vesselina Ferferieva, Ivo Lambrichts, Dominique Hansen, Bert O Eijnde, Virginie Bito
Diabetes mellitus (DM) is a major problem worldwide. Within this patient group, cardiovascular diseases are the biggest cause of morbidity and mortality. Diabetic cardiomyopathy (DCM) is defined as diabetes-associated structural and functional changes in the myocardium, not directly attributable to other confounding factors such as coronary artery disease or hypertension. Pathophysiology of DCM remains unclear due to a lack of adequate animal models reflecting the current pandemic of diabetes, associated with a high increased sugar intake and the 'Western' lifestyle...
August 21, 2018: Journal of Nutritional Biochemistry
Xia Xiao, Piu Saha, Beng San Yeoh, Jennifer A Hipp, Vishal Singh, Matam Vijay-Kumar
Iron deficiency is routinely treated with oral or systemic iron supplements, which are highly reactive and could induce oxidative stress via augmenting the activity of proinflammatory enzyme myeloperoxidase (MPO). To investigate the extent to which MPO is involved in iron-induced toxicity, acute (24 h) iron toxicity was induced by intraperitoneal administration of FeSO4 (25 mg/kg body weight) to MPO-deficient (MpoKO) mice and their wild-type (WT) littermates. Acute iron toxicity was also assessed in WT mice pretreated with an MPO inhibitor, 4-aminobenzoic acid hydrazide...
August 21, 2018: Journal of Nutritional Biochemistry
Dieli Oliveira Nunes, Vinicius Bermond Marques, Camila Cruz Pereira Almenara, Wena Dantas Marcarini, Rogério Faustino Ribeiro Júnior, Alessandra Simão Padilha
We aimed to investigate the effect of linoleic acid (LA) treatment on the blood pressure and function of mesenteric resistance arteries (MRA) in spontaneous hypertensive rats (SHR). Male SHR were treated daily with LA (15 mg/kg) or vehicle (control) for 15 days. Compared with controls, LA treatment decreased blood pressure and showed the following in MRA: (1) increased lumen and external diameter, (2) decreased wall:lumen ratio and wall thickness, (3) decreased stiffness and (4) less collagen deposition. LA treatment reduced the contractile response to phenylephrine, although there were no changes observed in MRA in regard to the acetylcholine or sodium nitroprusside responses...
August 17, 2018: Journal of Nutritional Biochemistry
Suprabhat Mukherjee, Nikhilesh Joardar, Subhasree Sengupta, Santi P Sinha Babu
The human gut microbiota has been the interest of extensive research in recent years and our knowledge on using the potential capacity of these microbes are growing rapidly. Microorganisms colonized throughout the gastrointestinal tract of human are coevolved through symbiotic relationship and can influence physiology, metabolism, nutrition and immune functions of an individual. The gut microbes are directly involved in conferring protection against pathogen colonization by inducing direct killing, competing with nutrients and enhancing the response of the gut-associated immune repertoire...
August 16, 2018: Journal of Nutritional Biochemistry
Livia N Chassot, Bianca Scolaro, Gabriela G Roschel, Bruno Cogliati, Marcela F Cavalcanti, Dulcineia S P Abdalla, Inar A Castro
Moderate consumption of red wine has been widely associated with reduced cardiovascular risk, mainly due to its composition in phenolic compounds with antioxidant activity, such as resveratrol. The objective of this study was to compare the effect of red wine vs. trans-resveratrol consumption on the prevention and regression of atherosclerosis in LDLr (-/-) mice. This study consisted of two protocols: "Prevention" (PREV) and "Regression" (REGR). Both protocols included four groups: red wine (WINE), dealcoholized red wine (EXT), trans-resveratrol (RESV), and control (CONT)...
August 16, 2018: Journal of Nutritional Biochemistry
Md Ariful Islam, Amir Ravandi, Harold M Aukema
High protein (HP) diets are often used as a means to reduce obesity, but their long-term effects remain unclear. In vitro studies suggest the involvement of a subset of oxylipins in the tissue response to HP diets. To examine the role of these bioactive lipids in vivo, normal adult male Sprague Dawley rats were provided isocaloric diets with LP (low protein, 8% protein by weight), NP (normal protein, 14%) or HP (50%) diets for 2 weeks, and targeted lipidomic analysis of oxylipins in kidney (cortex and medulla), liver and serum was performed by HPLC-MS/MS...
August 15, 2018: Journal of Nutritional Biochemistry
Daqian Yang, Siyu Li, Li Gao, Zhanjun Lv, Qizheng Bing, Qingjie Lv, Xiaoyan Zheng, Ruobing Li, Zhigang Zhang
To investigate the protective role of grape seed procyanidin extract (GSPE) against lead-induced heart injury and the possible molecular mechanism associated with this event, Wistar rats were orally given GSPE (200 mg/kg) daily with or without lead acetate (PbA) (0.5 g/L) in drinking water for 56 d. GSPE attenuated oxidative stress, heart dysfunction, and lead accumulation in lead-exposed rat hearts. Meanwhile, GSPE inhibited the protein kinase RNA-like endoplasmic reticulum (ER) kinase/eukaryotic initiation factor 2α signaling pathway, and promoted protein kinase B (AKT) and glycogen synthase kinase 3β phosphorylation altered by lead, and regulated lead-activated apoptosis and its related signaling pathway...
August 14, 2018: Journal of Nutritional Biochemistry
Gianluca Sgarbi, Francesca Liuzzi, Alessandra Baracca, Giancarlo Solaini
Dysfunctions caused by genetic defects in the mitochondrial DNA (mtDNA) of humans are called mitochondrial diseases; however, mtDNA mutations are also associated with aging and age-related diseases. Here, we present an original cellular model that allows gathering information on molecules that might contrast or prevent mitochondrial dysfunctions and their related diseases. This model allowed us to show that resveratrol (RSV), a phytochemical present in food, exerts protective effects at low concentrations on resting human fibroblasts carrying dysfunctional respiratory chain Complex I...
August 14, 2018: Journal of Nutritional Biochemistry
Jun Zhou, Lili Tang, Chwan-Li Shen, Jia-Sheng Wang
Our recent metagenomics analysis has uncovered remarkable modifying effects of green tea polyphenols (GTP) on gut-microbiota community structure and energy conversion related gene orthologs in rats. How these genomic changes could further influence host health is still unclear. In this work, the alterations of gut-microbiota dependent metabolites were studied in the GTP-treated rats. Six groups of female SD rats (n=12/group) were administered drinking water containing 0%, 0.5%, and 1.5% GTP (wt/vol). Their gut contents were collected at 3 and 6 months and were analyzed via high performance liquid chromatography (HPLC) and gas chromatography (GC)-mass spectrometry (MS)...
August 14, 2018: Journal of Nutritional Biochemistry
Sergio Davinelli, Graziamaria Corbi, Armando Zarrelli, Mariachiara Arisi, Piergiacomo Calzavara-Pinton, Davide Grassi, Immaculata De Vivo, Giovanni Scapagnini
We evaluated the short-term effects of a flavanol-rich cocoa (FRC) on lipid profile and selected oxidative stress biomarkers such as oxidized low-density lipoprotein (oxLDL), glutathione (GSH), and F2 -isoprostane. We also assessed whether FRC modulates plasma levels of polyunsaturated fatty acids (PUFA) in healthy individuals. The subjects (n=48) were randomly assigned to a low-cocoa group (1 g/d; ~55 mg flavanols) (n=16), middle-cocoa group (2 g/d; ~110 mg flavanols) (n=16), or a high-cocoa group (4 g/d; ~220 mg flavanols) (n=16)...
August 14, 2018: Journal of Nutritional Biochemistry
Muthukumaran Jayachandran, Jiali Chen, Stephen Sum Man Chung, Baojun Xu
The β-glucans are the glucose polymers present in the cells walls of yeast, fungi and cereals. β-Glucans are the major compositions of various nutritional diets such as oats, barley, seaweeds and mushrooms. Various biological activities of β-glucans have been reported such as anticancer, antidiabetic, anti-inflammatory and immune-modulating effects. The importance of β-glucans in food processing industries such as bread preparation, yogurt and pasta have been well elucidated. In recent findings on food science research gut microbiota plays a significant role and vastly studied for its intermediate role in regulating health...
August 10, 2018: Journal of Nutritional Biochemistry
Santiago Bianconi, María E Santillán, María Del Rosario Solís, Ana C Martini, Marina F Ponzio, Laura M Vincenti, Helgi B Schiöth, Valeria P Carlini, Graciela Stutz
Omega-3 polyunsaturated fatty acids (ω-3 PUFAs) are relevant to fetal and infant growth and development. OBJECTIVE: to assess whether long-term exposure to dietary ω-3 PUFA imbalance alters pre- and/or postnatal pups' development and reproductive function later in life. Mice dams were fed with ω-3 PUFA Control (soybean oil, 7%), Deficient (sunflower oil, 7%) or Excess (blend oil; 4.2% cod-liver+2.8% soybean) diet before conception and throughout gestation-lactation and later on, their pups received the same diet from weaning to adulthood...
July 26, 2018: Journal of Nutritional Biochemistry
Rodrigo Mello Gomes, Fernanda Giacomini Bueno, Christiano Rodrigues Schamber, João Carlos Palazzo de Mello, Júlio Cezar de Oliveira, Flávio Andrade Francisco, Veridiana Mota Moreira, Marcos Divino Ferreira Junior, Gustavo Rodrigues Pedrino, Paulo Cezar de Freitas Mathias, Rosiane Aparecida Miranda, Solange Marta Franzói de Moraes, Maria Raquel Marçal Natali
During the early post-natal period, offspring are vulnerable to environmental insults, such as nutritional and hormonal changes, which increase risk to develop metabolic diseases later in life. Our aim was to understand whether maternal obesity during lactation programs offspring to metabolic syndrome and obese phenotype, in addition we aimed to assess the peripheral glucose metabolism and hypothalamic leptin/insulin signaling pathways. At delivery, female Wistar rats were randomly divided in two groups: Control group (CO), mothers fed a standard rodent chow (Nuvilab); and Diet-induced obesity group (DIO), mothers who had free access to a diet performed with 33% ground standard rodent chow, 33% sweetened condensed milk (Nestlé), 7% sucrose and 27% water...
July 25, 2018: Journal of Nutritional Biochemistry
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