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Journal of Nutritional Biochemistry

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https://www.readbyqxmd.com/read/28797930/%C3%AE-tocotrienol-induced-disruption-of-lipid-rafts-in-human-breast-cancer-cells-is-associated-with-a-reduction-in-exosome-heregulin-content
#1
Osama A Alawin, Rayan A Ahmed, Venkateshwararao Dronamraju, Karen P Briski, Paul W Sylvester
Overexpression of heregulin, a potent ligand that activates HER3 and HER4 receptors, plays a significant role in the development of chemotherapy resistance in breast cancer patients. Exosomes released from cancer cells are small vesicles originating from the outward budding of lipid rafts that carry various mitogenic proteins that then act locally in an autocrine/paracrine manner to stimulate cancer cell growth. Since the anticancer activity of γ-tocotrienol has been shown to be mediated in part through the disruption of lipid rafts, studies were conducted to determine the effect of γ-tocotrienol on exosomes mitogenic biopotency...
July 10, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/28810182/selenium-increases-hepatic-dna-methylation-and-modulates-one-carbon-metabolism-in-the-liver-of-mice
#2
Bodo Speckmann, Sarah Schulz, Franziska Hiller, Deike Hesse, Fabian Schumacher, Burkhard Kleuser, Jürgen Geisel, Rima Obeid, Tilman Grune, Anna P Kipp
The average intake of the essential trace element selenium (Se) is below the recommendation in most European countries, possibly causing sub-optimal expression of selenoproteins. It is still unclear how a suboptimal Se status may affect health. To mimic this situation, mice were fed one of three physiologically relevant amounts of Se. We focused on the liver, the organ most sensitive to changes in the Se supply indicated by hepatic glutathione peroxidase activity. In addition, liver is the main organ for synthesis of methyl groups and glutathione via one-carbon metabolism...
July 9, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/28797931/changes-in-the-gut-microbial-communities-following-addition-of-walnuts-to-the-diet
#3
Lauri O Byerley, Derrick Samuelson, Eugene Blanchard, Meng Luo, Brittany N Lorenzen, Shelia Banks, Monica A Ponder, David A Welsh, Christopher M Taylor
Walnuts are rich in omega-3 fatty acids, phytochemicals and antioxidants making them unique compared to other foods. Consuming walnuts has been associated with health benefits including a reduced risk of heart disease and cancer. Dysbiosis of the gut microbiome has been linked to several chronic diseases. One potential mechanism by which walnuts may exert their health benefit is through modifying the gut microbiome. This study identified the changes in the gut microbial communities that occur following the inclusion of walnuts in the diet...
July 9, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/28797929/antiallergic-effect-of-fisetin-on-ige-mediated-mast-cell-activation-in-vitro-and-on-passive-cutaneous-anaphylaxis-pca
#4
Woo-Ri Jo, Hye-Jin Park
Fisetin (3,7,3',4'-tetrahydroxyflavone), a naturally occurring bioactive flavonoid, has been shown to inhibit inflammation. However, little is known about the effect of fisetin on immunoglobulin E (IgE)-mediated allergic responses. In this study, the effect of fisetin on rat basophilic leukemia (RBL-2H3) cell-mediated allergic reactions was investigated. Fisetin inhibited β-hexosaminidase release and decreased the level of interleukin-4 and tumor necrosis factor-α mRNA in IgE/antigen (IgE/Ag)-stimulated RBL-2H3 cells...
June 30, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/28779634/obesity-and-malnutrition-similarly-alters-the-renin-angiotensin-system-and-inflammation-in-mice-and-human-adipose
#5
Thales de Almeida Pinheiro, Antônio Sérgio Barcala-Jorge, João Marcus Oliveira Andrade, Thaisa de Almeida Pinheiro, Emíllio César Neves Ferreira, Thaisa Soares Crespo, Gislaine Candida Batista-Jorge, Cássio André Vieira, Deborah de Farias Lelis, Alanna Fernandes Paraíso, Ugo Borges Pinheiro, Mariane Bertagnolli, Carlos Juliano Brant Albuquerque, André Luiz Sena Guimarães, Alfredo Mauricio Batista de Paula, Antônio Prates Caldeira, Sérgio Henrique Sousa Santos
The main goal of the present study was to evaluate the metabolic profile, inflammatory markers and the gene expression of the renin-angiotensin system (RAS) components in the visceral adipose tissue of eutrophic, obese and malnourished individuals and mice models of obesity and food restriction. Male Swiss mice were divided into eight groups and fed different levels of food restriction (20%, 40%, or 60%) using standard or high-fat diet. Metabolic profile and adipose tissues were assessed. The expression of AGT (Angiotensinogen), ACE (Angiotensin-converting enzyme), ACE2 (Angiotensin-converting enzyme 2), interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α) in the mice epididymal adipose tissue and the human visceral adipose tissue was assessed...
June 24, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/28772148/a-type-ecg-and-egcg-dimers-inhibit-3t3-l1-differentiation-by-binding-to-cholesterol-in-lipid-rafts
#6
Wei Zhu, Xiangyi Deng, Jinming Peng, Bo Zou, Chunmei Li
The present study aimed to explore the underlying mechanisms of epicatechin-3-gallate-(4β→8, 2β→O→7)-epicatechin-3-gallate (A-type ECG dimer) and epigallocatechin-3-gallate-(4β→8, 2β→O→7)-epigallocatechin-3-gallate (A-type EGCG dimer) involved in their strong inhibitory effects on 3T3-L1 preadipocytes differentiation. In the synthetic "lipid raft-like" liposome, A-type ECG and EGCG dimers incorporated into the liposome with high affinity and decreased the fluidity of the liposome. In 3T3-L1 preadipocytes, A-type ECG and EGCG dimers possibly bonded to lipid rafts cholesterol and disrupted the integrity of lipid rafts, thus exerting their notable inhibitory effects on 3T3-L1 preadipocytes differentiation by suppressing mitotic clonal expansion process and mRNA levels of PPARγ, C/EBPα and SREBP1C...
June 24, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/28759787/ferulic-acid-a-bioactive-component-of-rice-bran-improves-oxidative-stress-and-mitochondrial-biogenesis-and-dynamics-in-mice-and-in-human-mononuclear-cells
#7
Cristina Perez-Ternero, Christian M Werner, Alexander G Nickel, Maria Dolores Herrera, Maria-José Motilva, Michael Böhm, Maria Alvarez de Sotomayor, Ulrich Laufs
The aim of the study was to characterize the vascular effects of rice bran enzymatic extract (RBEE). ApoE-/- mice were fed a high-fat/cholesterol diet (HFD) or HFD supplemented with 5% RBEE for 21 weeks. RBEE prevented development of atherosclerotic plaques and oxidative stress in mouse aorta as well as the down-regulation of markers of mitochondrial biogenesis. Analysis of the bioactive components identified ferulic acid (FA) as responsible component. In healthy human volunteers, FA intake reduced NADPH oxidase activity, superoxide release, apoptosis and necrosis in peripheral blood mononuclear cells...
June 24, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/28759786/high-purity-tocotrienols-attenuate-atherosclerotic-lesion-formation-in-apoe-ko-mice
#8
Akira Shibata, Teiko Kobayashi, Akira Asai, Takahiro Eitsuka, Shinichi Oikawa, Teruo Miyazawa, Kiyotaka Nakagawa
Previous studies have demonstrated that tocotrienol (T3) has antiatherogenic effects. However, the T3 preparations used in those studies contained considerable amounts of tocopherol (Toc), which might affect the biological activity of T3. There is little information on the effect of highly purified T3 on atherosclerosis formation. This study investigated the effect of high-purity T3 on atherosclerotic lesion formation and the underlying mechanisms. Male apolipoprotein E knockout (apoE-KO) mice were fed a cholesterol-containing diet either alone or supplemented with T3 concentrate (Toc-free T3) or with α-Toc for 12 weeks...
June 24, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/28672272/%C3%AF-3-polyunsaturated-fatty-acids-and-their-cytochrome-p450-derived-metabolites-suppress-colorectal-tumor-development-in-mice
#9
Weicang Wang, Jun Yang, Yoshiki Nimiya, Kin Sing Stephen Lee, Katherine Sanidad, Weipeng Qi, Elvira Sukamtoh, Yeonhwa Park, Zhenhua Liu, Guodong Zhang
Many studies have shown that dietary intake of ω-3 polyunsaturated fatty acids (PUFAs) reduces the risks of colorectal cancer; however, the underlying mechanisms are not well understood. Here we used a LC-MS/MS-based lipidomics to explore the role of eicosanoid signaling in the anti-colorectal cancer effects of ω-3 PUFAs. Our results showed that dietary feeding of ω-3 PUFAs-rich diets suppressed growth of MC38 colorectal tumor, and modulated profiles of fatty acids and eicosanoid metabolites in C57BL/6 mice...
June 21, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/28654829/fructose-intake-exacerbates-the-contractile-response-elicited-by-norepinephrine-in-mesenteric-vascular-bed-of-rats-via-increased-endothelial-prostanoids
#10
Glauciene J Sousa, Phablo Wendell C Oliveira, Breno V Nogueira, Antônio F Melo, Thaís de Oliveira Faria, Eduardo Frizera Meira, José G Mill, Nazaré S Bissoli, Marcelo P Baldo
Chronic fructose intake induces major cardiovascular and metabolic disturbances and is associated with the development of hypertension due to changes in vascular function. We hypothesized that high fructose intake for 6 weeks would cause metabolic syndrome and lead to initial vascular dysfunction. Male Wistar rats were assigned to receive fructose (FRU, 10%) or drinking water (CON) for 6 weeks. Systolic blood pressure was evaluated by tail plethysmography. Fasting glucose, insulin and glucose tolerance were measured at the end of the follow-up...
June 20, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/28651168/the-antioxidant-and-anti-inflammatory-properties-of-lycopene-in-mice-lungs-exposed-to-cigarette-smoke
#11
Keila Karine Duarte Campos, Glaucy Rodrigues Araújo, Thais Lourenço Martins, Ana Carla Balthar Bandeira, Guilherme de Paula Costa, André Talvani, Camila Carrião Machado Garcia, Laser Antônio Machado Oliveira, Daniela Caldeira Costa, Frank Silva Bezerra
Lycopene is a carotenoid with known antioxidant and anti-inflammatory properties. We aimed to evaluate the in vitro and in vivo effects of lycopene on reducing the redox imbalance and inflammation induced by cigarette smoke (CS). For the in vitro study, J774A.1 (macrophages) cells were incubated in the presence of 0.5, 1.0, 2.0, 4.0, 8.0, 10.0 and 25 μM of lycopene for 3, 6 and 24 h or in the presence of 0.1%, 0.25%, 0.5%, 0.625%, 1.25%, 2.25%, 5% and 10% cigarette smoke extract (CSE) for 3, 6 and 24 h to assess cell viability and measurement of intracellular reactive oxygen species (ROS)...
June 20, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/28692847/microbial-metabolites-are-associated-with-a-high-adherence-to-a-mediterranean-dietary-pattern-using-a-1-h-nmr-based-untargeted-metabolomics-approach
#12
Enrique Almanza-Aguilera, Mireia Urpi-Sarda, Rafael Llorach, Rosa Vázquez-Fresno, Mar Garcia-Aloy, Francesc Carmona, Alex Sanchez, Francisco Madrid-Gambin, Ramon Estruch, Dolores Corella, Cristina Andres-Lacueva
The study of biomarkers of dietary patterns including the Mediterranean diet (MedDiet) is scarce and could improve the assessment of these patterns. Moreover, it could provide a better understanding of health benefits of dietary patterns in nutritional epidemiology. We aimed to determine a robust and accurate biomarker associated with a high adherence to a MedDiet pattern that included dietary assessment and its biological effect. In this cross-sectional study, we included 56 and 63 individuals with high (H-MDA) and low (L-MDA) MedDiet adherence categories, respectively, all from the Prevención con Dieta Mediterránea trial...
June 7, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/28628909/nonalcoholic-fatty-liver-disease-impairs-the-cytochrome-p-450-dependent-metabolism-of-%C3%AE-tocopherol-vitamin-e
#13
Desirée Bartolini, Pierangelo Torquato, Carolina Barola, Angelo Russo, Chiara Rychlicki, Danilo Giusepponi, Guido Bellezza, Angelo Sidoni, Roberta Galarini, Gianluca Svegliati-Baroni, Francesco Galli
This study aims to investigate in in vivo and in vitro models of nonalcoholic fatty liver disease (NAFLD) the enzymatic metabolism of α-tocopherol (vitamin E) and its relationship to vitamin E-responsive genes with key role in the lipid metabolism and detoxification of the liver. The experimental models included mice fed a high-fat diet combined or not with fructose (HFD+F) and HepG2 human hepatocarcinoma cells treated with the lipogenic agents palmitate, oleate or fructose. CYP4F2 protein, a cytochrome P-450 isoform with proposed α-tocopherol ω-hydroxylase activity, decreased in HFD and even more in HFD+F mice liver; this finding was associated with increased hepatic levels of α-tocopherol and decreased formation of the corresponding long-chain metabolites α-13-hydroxy and α-13-carboxy chromanols...
June 7, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/28623808/role-of-polyphenols-and-polyphenol-rich-foods-in-the-modulation-of-pon1-activity-and-expression
#14
REVIEW
Daniela Martini, Cristian Del Bo', Marisa Porrini, Salvatore Ciappellano, Patrizia Riso
Paraoxonase 1 (PON1) is a high-density lipoprotein (HDL)-associated enzyme involved in the protection of low-density lipoprotein and HDLs against lipid peroxidation. Several studies documented the capacity of polyphenols to stimulate PON1 transcription activation. The objective of the present review is to provide the main evidence about the role and the potential mechanism of action of polyphenols and polyphenol-rich foods in the modulation of PON1 gene expression and activity. A total of 76 in vitro and in vivo studies were included in the review...
June 6, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/28628798/maternal-liver-docosahexaenoic-acid-dha-stores-are-increased-via-higher-serum-unesterified-dha-uptake-in-pregnant-long-evans-rats
#15
Adam H Metherel, Alex P Kitson, Anthony F Domenichiello, R J Scott Lacombe, Kathryn E Hopperton, Marc-Olivier Trépanier, Shoug M Alashmali, Lin Lin, Richard P Bazinet
Maternal docosahexaenoic acid (DHA, 22:6n-3) supplies the developing fetus during pregnancy; however, the mechanisms are unclear. We utilized pregnant rats to determine rates of DHA accretion, tissue unesterified DHA uptake and whole-body DHA synthesis-secretion. Female rats maintained on a DHA-free, 2% α-linolenic acid diet were either:1) sacrificed at 56 days for baseline measures, 2) mated and sacrificed at 14-18 days of pregnancy or 3) or sacrificed at 14-18 days as age-matched virgin controls. Maternal brain, adipose, liver and whole body fatty acid concentrations was determined for balance analysis, and kinetic modeling was used to determine brain and liver plasma unesterified DHA uptake and whole-body DHA synthesis-secretion rates...
June 1, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/28599197/tomato-lycopersicon-esculentum-or-lycopene-supplementation-attenuates-ventricular-remodeling-after-myocardial-infarction-through-different-mechanistic-pathways
#16
Bruna L B Pereira, Patrícia P Reis, Fábio E Severino, Tainara F Felix, Mariana G Braz, Flávia R Nogueira, Renata A C Silva, Ana C Cardoso, Maria A M Lourenço, Amanda M Figueiredo, Fernanda Chiuso-Minicucci, Paula S Azevedo, Bertha F Polegato, Katashi Okoshi, Ana A H Fernandes, Sergio A R Paiva, Leonardo A M Zornoff, Marcos F Minicucci
The objective of this study was to evaluate the influence of tomato or lycopene supplementation on cardiac remodeling after myocardial infarction (MI). Male Wistar rats were assigned to four groups: the sham group (animals that underwent simulated surgery) that received a standard chow (S; n=18), the infarcted group that received a standard chow (MI; n=13), the infarcted group supplemented with lycopene (1 mg of lycopene/kg body weight/day) (MIL; n=16) and the infarcted group supplemented with tomato (MIT; n=16)...
June 1, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/28582660/the-phytochemical-3-3-diindolylmethane-decreases-expression-of-ar-controlled-dna-damage-repair-genes-through-repressive-chromatin-modifications-and-is-associated-with-dna-damage-in-prostate-cancer-cells
#17
Zoraya Palomera-Sanchez, Gregory W Watson, Carmen P Wong, Laura M Beaver, David E Williams, Roderick H Dashwood, Emily Ho
Androgen receptor (AR) is a transcription factor involved in normal prostate physiology and prostate cancer (PCa) development. 3,3'-Diindolylmethane (DIM) is a promising phytochemical agent against PCa that affects AR activity and epigenetic regulators in PCa cells. However, whether DIM suppresses PCa via epigenetic regulation of AR target genes is unknown. We assessed epigenetic regulation of AR target genes in LNCaP PCa cells and showed that DIM treatment led to epigenetic suppression of AR target genes involved in DNA repair (PARP1, MRE11, DNA-PK)...
May 25, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/28575756/dietary-fatty-acids-modulate-adipocyte-tnfa-production-via-regulation-of-its-dna-promoter-methylation-levels
#18
Eva García-Escobar, Roberto Monastero, Sara García-Serrano, Juan M Gómez-Zumaquero, Ana Lago-Sampedro, Elehazara Rubio-Martín, Natalia Colomo, Francisca Rodríguez-Pacheco, Federico Soriguer, Gemma Rojo-Martínez
The factors regulating TNF alpha (TNFa) levels could be considered therapeutic targets against metabolic syndrome development. DNA methylation is a potent regulator of gene expression and may be associated with protein levels. In this study we investigate whether the effect of dietary fatty acids on TNFa released from adipocytes might be associated with modifications of the TNFa promoter DNA methylation status. A group of rats was assigned to three diets with a different composition of saturated, monounsaturated and polyunsaturated fatty acids...
May 25, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/28570943/%C3%AE-glucosidase-inhibitory-effect-of-resveratrol-and-piceatannol
#19
Albert J Zhang, Agnes M Rimando, Cassia S Mizuno, Suresh T Mathews
Dietary polyphenols have been shown to inhibit α-glucosidase, an enzyme target of some antidiabetic drugs. Resveratrol, a polyphenol found in grapes and wine, has been reported to inhibit the activity of yeast α-glucosidase. This triggered our interest to synthesize analogs and determine their effect on mammalian α-glucosidase activity. Using either sucrose or maltose as substrate resveratrol, piceatannol and 3'-hydroxypterostilbene showed strong inhibition of mammalian α-glucosidase activity; pinostilbene, cis-desoxyrhapontigenin and trans-desoxyrhapontigenin had moderate inhibition...
May 25, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/28570942/the-change-in-retinoic-acid-receptor-signaling-induced-by-prenatal-marginal-vitamin-a-deficiency-and-its-effects-on-learning-and-memory
#20
Xuan Zhang, Xingang Yuan, Lijun Chen, Hua Wei, Jie Chen, Tingyu Li
This study investigated the prenatal marginal vitamin A deficiency (mVAD)-related impairment in learning and memory and the interactions between RARα, Src and NR1. Learning and memory were assessed in adult rats that were exposed to prenatal mVAD with Morris water maze. The average escape time was longer in mVAD rats, and they passed the hidden platform fewer times during the memory retention test than normal vitamin A intake (VAN) rats. The mRNA and protein levels of RARα, Src and NR1 in mVAD rats were significantly lower than those in VAN rats...
May 25, 2017: Journal of Nutritional Biochemistry
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