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Journal of Nutritional Biochemistry

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https://www.readbyqxmd.com/read/28917953/migratory-capacity-and-function-of-dendritic-cells-from-mesenteric-afferent-lymph-nodes-after-feeding-a-single-dose-of-vitamin-a
#1
Ivanna Novotny Nuñez, Bibiana E Barrios, Lisa Macció-Maretto, Silvia G Correa
Lamina propria dendritic cells (DCs) have a permanent turnover with constitutive migration to mesenteric lymph nodes and replenishment by progenitors. Luminal bacteria and dietary constituents provide key signals that endow DCs their unique properties in vivo. Taking into account that the intestinal immune system is greatly influenced by retinoids, we evaluated in B6 mice 3, 8, 16 and 24 h after feeding a single dose of vitamin A phenotype and function of cells present in mesenteric afferent lymph nodes as well as signals involved in migration...
August 24, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/28915389/choline-prevents-fetal-overgrowth-and-normalizes-placental-fatty-acid-and-glucose-metabolism-in-a-mouse-model-of-maternal-obesity
#2
Juha Nam, Esther Greenwald, Chauntelle Jack-Roberts, Tamara T Ajeeb, Olga V Malysheva, Marie A Caudill, Kathleen Axen, Anjana Saxena, Ekaterina Semernina, Khatia Nanobashvili, Xinyin Jiang
Maternal obesity increases placental transport of macronutrients, resulting in fetal overgrowth and obesity later in life. Choline participates in fatty acid metabolism, serves as a methyl donor and influences growth signaling, which may modify placental macronutrient homeostasis and affect fetal growth. Using a mouse model of maternal obesity, we assessed the effect of maternal choline supplementation on preventing fetal overgrowth and restoring placental macronutrient homeostasis. C57BL/6J mice were fed either a high-fat (HF, 60% kcal from fat) diet or a normal (NF, 10% kcal from fat) diet with a drinking supply of either 25 mM choline chloride or control purified water, respectively, beginning 4 weeks prior to mating until gestational day 12...
August 12, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/28886438/daidzein-down-regulates-ubiquitin-specific-protease-19-expression-through-estrogen-receptor-%C3%AE-and-increases-skeletal-muscle-mass-in-young-female-mice
#3
Masahiro Ogawa, Takehiro Kitano, Natsuha Kawata, Takashi Sugihira, Tomoya Kitakaze, Naoki Harada, Ryoichi Yamaji
Ubiquitin-specific protease 19 (USP19) is a key player in the negative regulation of muscle mass during muscle atrophy. Loss-of-function approaches demonstrate that 17β-estradiol (E2) increases USP19 expression through estrogen receptor (ER) α and consequently decreases soleus muscle mass in young female mice under physiological conditions. Daidzein is one of the main isoflavones in soy, and activates ERβ-dependent transcription. Here, we investigated the effects of daidzein on E2-increased USP19 expression and E2-decreased soleus muscle mass in young female mice...
August 12, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/28915390/navy-and-black-bean-supplementation-primes-the-colonic-mucosal-microenvironment-to-improve-gut-health
#4
Jennifer M Monk, Dion Lepp, Wenqing Wu, K Peter Pauls, Lindsay E Robinson, Krista A Power
Common beans (Phaseolus vulgaris L.) are enriched in non-digestible fermentable carbohydrates and phenolic compounds that can modulate the colonic microenvironment (microbiota and host epithelial barrier) to improve gut health. In a comprehensive assessment of the impact of two commonly consumed bean varieties (differing in levels and types of phenolic compounds) within the colonic microenvironment, C57Bl/6 mice were fed diets supplemented with 20% cooked navy bean (NB) or black bean (BB) flours or an isocaloric basal diet control (BD) for 3 weeks...
August 10, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/28915388/epa-and-dha-but-not-ala-have-antidepressant-effects-with-17%C3%AE-estradiol-injection-via-regulation-of-a-neurobiological-system-in-ovariectomized-rats
#5
Jeong-Eun Choi, Yongsoon Park
Our previous studies found that n-3 polyunsaturated fatty acids (PUFAs) and estrogen had synergistic antidepressant-like effects. The purpose of the present study was to investigate the hypothesis that three major n-3 PUFAs, α-linolenic acid (ALA), eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), individually had antidepressant effects combined with 17β-estradiol-3-benzoate (E) through a neurobiological pathway in ovariectomized rats. Rats were fed a modified American Institute of Nutrition-93G diet with 0% n-3 PUFAs and 1% ALA, EPA and DHA relative to total energy intake for 12 weeks and were injected with corn oil or E every 4 days during the last 3 weeks...
August 5, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/28866105/dietary-phlorizin-enhances-osteoblastogenic-bone-formation-through-enhancing-%C3%AE-catenin-activity-via-gsk-3%C3%AE-inhibition-in-a-model-of-senile-osteoporosis
#6
Lucia Dwi Antika, Eun-Jung Lee, Yun-Ho Kim, Min-Kyung Kang, Sin-Hye Park, Dong Yeon Kim, Hyeongjoo Oh, Yean-Jung Choi, Young-Hee Kang
Osteoporosis is one of the most prevalent forms of age-related bone diseases. Increased bone loss with advancing age has become a grave public health concern. This study examined whether phlorizin and phloretin, dihydrochalcones in apple peels, inhibited senile osteoporosis through enhancing osteoblastogenic bone formation in cell-based and aged mouse models. Submicromolar phloretin and phlorizin markedly stimulated osteoblast differentiation of MC3T3-E1 cells with increased transcription of Runx2 and osteocalcin...
July 28, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/28886437/apple-and-blackcurrant-polyphenol-rich-drinks-decrease-postprandial-glucose-insulin-and-incretin-response-to-a-high-carbohydrate-meal-in-healthy-men-and-women
#7
Monica L Castro-Acosta, Stephanie G Stone, Jonathan E Mok, Rhia K Mhajan, Chi-Ieng Fu, Georgia N Lenihan-Geels, Christopher P Corpe, Wendy L Hall
Postprandial glycemic responses to meals are inhibited by polyphenol-rich plant foods. Combinations of polyphenols may be particularly effective through complementary mechanisms. A randomized, controlled, double-blinded cross-over trial was conducted in healthy volunteers to test the hypothesis that apple and blackcurrant polyphenol-rich drinks would reduce postprandial blood glucose concentrations. Secondary outcomes included insulin and glucose-dependent insulinotropic polypeptide (GIP) secretion. Twenty men (mean age 26 y, SD 8) and 5 postmenopausal women (mean age 57 y, SD 3) consumed a placebo drink (CON) and 2 polyphenol-rich drinks containing fruit extracts: either 1200 mg apple polyphenols (AE), or 600 mg apple polyphenols+600 mg blackcurrant anthocyanins (AE+BE), in random order with a starch and sucrose meal...
July 27, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/28863367/monomeric-cocoa-catechins-enhance-%C3%AE-cell-function-by-increasing-mitochondrial-respiration
#8
Thomas J Rowley, Benjamin F Bitner, Jason D Ray, Daniel R Lathen, Andrew T Smithson, Blake W Dallon, Chase J Plowman, Benjamin T Bikman, Jason M Hansen, Melanie R Dorenkott, Katheryn M Goodrich, Liyun Ye, Sean F O'Keefe, Andrew P Neilson, Jeffery S Tessem
A hallmark of type 2 diabetes (T2D) is β-cell dysfunction and the eventual loss of functional β-cell mass. Therefore, mechanisms that improve or preserve β-cell function could be used to improve the quality of life of individuals with T2D. Studies have shown that monomeric, oligomeric and polymeric cocoa flavanols have different effects on obesity, insulin resistance and glucose tolerance. We hypothesized that these cocoa flavanols may have beneficial effects on β-cell function. INS-1 832/13-derived β-cells and primary rat islets cultured with a monomeric catechin-rich cocoa flavanol fraction demonstrated enhanced glucose-stimulated insulin secretion, while cells cultured with total cocoa extract and with oligomeric or polymeric procyanidin-rich fraction demonstrated no improvement...
July 27, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/28886439/chronic-high-sucrose-diet-increases-fibroblast-growth-factor-21-production-and-energy-expenditure-in-mice
#9
Ryuya Maekawa, Yusuke Seino, Hidetada Ogata, Masatoshi Murase, Atsushi Iida, Kaori Hosokawa, Erina Joo, Norio Harada, Shin Tsunekawa, Yoji Hamada, Yutaka Oiso, Nobuya Inagaki, Yoshitaka Hayashi, Hiroshi Arima
Excess carbohydrate intake causes obesity in humans. On the other hand, acute administration of fructose, glucose or sucrose in experimental animals has been shown to increase the plasma concentration of anti-obesity hormones such as glucagon-like peptide 1 (GLP-1) and Fibroblast growth factor 21 (FGF21), which contribute to reducing body weight. However, the secretion and action of GLP-1 and FGF21 in mice chronically fed a high-sucrose diet has not been investigated. To address the role of anti-obesity hormones in response to increased sucrose intake, we analyzed mice fed a high-sucrose diet, a high-starch diet or a normal diet for 15 weeks...
July 25, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/28863366/fat-enriched-rather-than-high-fructose-diets-promote-whitening-of-adipose-tissue-in-a-sex-dependent-manner
#10
Jochen Dobner, Claudia Ress, Kerstin Rufinatscha, Karin Salzmann, Willi Salvenmoser, Sabrina Folie, Verena Wieser, Patrizia Moser, Guenter Weiss, Georg Goebel, Herbert Tilg, Susanne Kaser
Adipose tissue is a critical regulator of energy metabolism and an effector organ of excessive caloric intake. We studied the effects of high-fructose (HFruD), high-fat (HFD) and mixed high-sucrose and high-fat diet (HFHSD) on adipocyte morphology and biology and consecutive metabolic effects in male and female C57BL/6 mice. Forty male and 40 female mice were randomly assigned to one of four dietary groups and fed for 10 weeks ad libitum. After 10 weeks of feeding, mice were analyzed in regard to glucose metabolism, insulin sensitivity and alteration in adipocyte morphology and function...
July 24, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/28863365/a-polyphenolic-extract-from-green-tea-leaves-activates-fat-browning-in-high-fat-diet-induced-obese-mice
#11
Audrey M Neyrinck, Laure B Bindels, Lucie Geurts, Matthias Van Hul, Patrice D Cani, Nathalie M Delzenne
Fat browning has emerged as an attractive target for the treatment of obesity and related metabolic disorders. Its activation leads to increased energy expenditure and reduced adiposity, thus contributing to a better energy homeostasis. Green tea extracts (GTEs) were shown to attenuate obesity and low-grade inflammation and to induce the lipolytic pathway in the white adipose tissue (WAT) of mice fed a high-fat diet. The aim of the present study was to determine whether the antiobesity effect of an extract from green tea leaves was associated with the activation of browning in the WAT and/or the inhibition of whitening in the brown adipose tissue (BAT) in HF-diet induced obese mice...
July 24, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/28863368/postprandial-effect-to-decrease-soluble-epoxide-hydrolase-activity-roles-of-insulin-and-gut-microbiota
#12
Jun Yang, Young Taek Oh, Debin Wan, Richard M Watanabe, Bruce D Hammock, Jang H Youn
Epoxides of free fatty acids (FFAs), especially epoxyeicosatrienoic acids (EETs), are lipid mediators with beneficial effects in metabolic and cardiovascular (CV) health. FFA epoxides are quickly metabolized to biologically less active diols by soluble epoxide hydrolase (sEH). Inhibition of sEH, which increases EET levels, improves glucose homeostasis and CV health and is proposed as an effective strategy for the treatment of diabetes and CV diseases. Here, we show evidence that sEH activity is profoundly reduced in postprandial states in rats; plasma levels of 17 sEH products (i...
July 21, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/28863364/high-energy-breakfast-based-on-whey-protein-reduces-body-weight-postprandial-glycemia-and-hba1c-in-type-2-diabetes
#13
Daniela Jakubowicz, Julio Wainstein, Zohar Landau, Bo Ahren, Maayan Barnea, Yosefa Bar-Dayan, Oren Froy
Acute studies show that addition of whey protein at breakfast has a glucose-lowering effect through increased incretin and insulin secretion. However, whether this is a long-term effect in Type 2 diabetes is unknown. Fifty-six Type 2 diabetes participants aged 58.9±4.5 years, BMI 32.1±0.9 kg/m(2) and HbA1C 7.8±0.1% (61.6±0.79 mmol/mol) were randomized to one of 3 isocaloric diets with similar lunch and dinner, but different breakfast: 1) 42 g total protein, 28 g whey (WBdiet, n=19); 2) 42 g various protein sources (PBdiet, n=19); or 3) high-carbohydrate breakfast, 17 g protein from various sources (CBdiet, n=18)...
July 21, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/28825992/effects-of-delta-tocotrienol-on-obesity-related-adipocyte-hypertrophy-inflammation-and-hepatic-steatosis-in-high-fat-fed-mice
#14
London Allen, Latha Ramalingam, Kalhara Menikdiwela, Shane Scoggin, Chwan-Li Shen, Michael D Tomison, Gurvinder Kaur, Jannette M Dufour, Eunhee Chung, Nishan S Kalupahana, Naima Moustaid-Moussa
Inflammation is a major underlying cause for obesity-associated metabolic diseases. Hence, anti-inflammatory dietary components may improve obesity-related disorders. We hypothesized that delta-tocotrienol (δT3), a member of the vitamin E family, reduces adiposity, insulin resistance and hepatic triglycerides through its anti-inflammatory properties. To test this hypothesis, C57BL/6J male mice were fed a high-fat diet (HF) with or without supplementation of δT3 (HF+δT3) at 400 mg/kg and 1600 mg/kg for 14 weeks, and they were compared to mice fed a low-fat diet (LF) or HF supplemented with metformin as an antidiabetic control...
July 10, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/28797930/%C3%AE-tocotrienol-induced-disruption-of-lipid-rafts-in-human-breast-cancer-cells-is-associated-with-a-reduction-in-exosome-heregulin-content
#15
Osama A Alawin, Rayan A Ahmed, Venkateshwararao Dronamraju, Karen P Briski, Paul W Sylvester
Overexpression of heregulin, a potent ligand that activates HER3 and HER4 receptors, plays a significant role in the development of chemotherapy resistance in breast cancer patients. Exosomes released from cancer cells are small vesicles originating from the outward budding of lipid rafts that carry various mitogenic proteins that then act locally in an autocrine/paracrine manner to stimulate cancer cell growth. Since the anticancer activity of γ-tocotrienol has been shown to be mediated in part through the disruption of lipid rafts, studies were conducted to determine the effect of γ-tocotrienol on exosomes mitogenic biopotency...
July 10, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/28810182/selenium-increases-hepatic-dna-methylation-and-modulates-one-carbon-metabolism-in-the-liver-of-mice
#16
Bodo Speckmann, Sarah Schulz, Franziska Hiller, Deike Hesse, Fabian Schumacher, Burkhard Kleuser, Jürgen Geisel, Rima Obeid, Tilman Grune, Anna P Kipp
The average intake of the essential trace element selenium (Se) is below the recommendation in most European countries, possibly causing sub-optimal expression of selenoproteins. It is still unclear how a suboptimal Se status may affect health. To mimic this situation, mice were fed one of three physiologically relevant amounts of Se. We focused on the liver, the organ most sensitive to changes in the Se supply indicated by hepatic glutathione peroxidase activity. In addition, liver is the main organ for synthesis of methyl groups and glutathione via one-carbon metabolism...
July 9, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/28797931/changes-in-the-gut-microbial-communities-following-addition-of-walnuts-to-the-diet
#17
Lauri O Byerley, Derrick Samuelson, Eugene Blanchard, Meng Luo, Brittany N Lorenzen, Shelia Banks, Monica A Ponder, David A Welsh, Christopher M Taylor
Walnuts are rich in omega-3 fatty acids, phytochemicals and antioxidants making them unique compared to other foods. Consuming walnuts has been associated with health benefits including a reduced risk of heart disease and cancer. Dysbiosis of the gut microbiome has been linked to several chronic diseases. One potential mechanism by which walnuts may exert their health benefit is through modifying the gut microbiome. This study identified the changes in the gut microbial communities that occur following the inclusion of walnuts in the diet...
July 9, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/28911548/corrigendum-to-guava-fruit-extract-and-its-triterpene-constituents-have-osteoanabolic-effect-stimulation-of-osteoblast-differentiation-by-activation-of-mitochondrial-respiration-via-the-wnt-%C3%AE-catenin-signalling-j-nutr-biochem-2017-44-22-34
#18
Konica Porwal, Subhashis Pal, Kapil Dev, Shyamsundar Pal China, Yogesh Kumar, Chandan Singh, Tarun Barbhuyan, Neeraj Sinha, Sabyasachi Sanyal, Arun Kumar Trivedi, Rakesh Maurya, Naibedya Chattopadhyay
No abstract text is available yet for this article.
October 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/28797929/antiallergic-effect-of-fisetin-on-ige-mediated-mast-cell-activation-in-vitro-and-on-passive-cutaneous-anaphylaxis-pca
#19
Woo-Ri Jo, Hye-Jin Park
Fisetin (3,7,3',4'-tetrahydroxyflavone), a naturally occurring bioactive flavonoid, has been shown to inhibit inflammation. However, little is known about the effect of fisetin on immunoglobulin E (IgE)-mediated allergic responses. In this study, the effect of fisetin on rat basophilic leukemia (RBL-2H3) cell-mediated allergic reactions was investigated. Fisetin inhibited β-hexosaminidase release and decreased the level of interleukin-4 and tumor necrosis factor-α mRNA in IgE/antigen (IgE/Ag)-stimulated RBL-2H3 cells...
October 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/28692847/microbial-metabolites-are-associated-with-a-high-adherence-to-a-mediterranean-dietary-pattern-using-a-1-h-nmr-based-untargeted-metabolomics-approach
#20
Enrique Almanza-Aguilera, Mireia Urpi-Sarda, Rafael Llorach, Rosa Vázquez-Fresno, Mar Garcia-Aloy, Francesc Carmona, Alex Sanchez, Francisco Madrid-Gambin, Ramon Estruch, Dolores Corella, Cristina Andres-Lacueva
The study of biomarkers of dietary patterns including the Mediterranean diet (MedDiet) is scarce and could improve the assessment of these patterns. Moreover, it could provide a better understanding of health benefits of dietary patterns in nutritional epidemiology. We aimed to determine a robust and accurate biomarker associated with a high adherence to a MedDiet pattern that included dietary assessment and its biological effect. In this cross-sectional study, we included 56 and 63 individuals with high (H-MDA) and low (L-MDA) MedDiet adherence categories, respectively, all from the Prevención con Dieta Mediterránea trial...
October 2017: Journal of Nutritional Biochemistry
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