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Current Opinion in Lipidology

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https://www.readbyqxmd.com/read/29035915/the-shape-of-things-to-come-in-lipid-management-a-feast-of-reason
#1
Gerald F Watts, Erik S G Stroes
No abstract text is available yet for this article.
October 13, 2017: Current Opinion in Lipidology
https://www.readbyqxmd.com/read/28957862/triglyceride-lowering-trials
#2
Anthony C Keech, Alicia J Jenkins
PURPOSE OF REVIEW: We provide an overview of current evidence about the independent role of high triglyceride levels for cardiovascular risk and for acute pancreatitis. RECENT FINDINGS: Natural experiments of Mendelian randomization have given us a deeper understanding about the molecular pathways involved in triglyceride metabolism. Individuals with low-triglyceride levels generally have lower rates of cardiovascular disease (CVD). There has been a significant growth in the development of new agents that modulate enzymes involved in a variety of aspects of triglyceride packaging into VLDL or chylomicron particles, and triglyceride catabolism...
September 27, 2017: Current Opinion in Lipidology
https://www.readbyqxmd.com/read/28937411/implications-of-glagov-study
#3
Stephen J Nicholls, Rishi Puri
PURPOSE OF REVIEW: Proprotein convertase subtilisin kexin type 9 (PCSK9) inhibition has emerged as a novel approach to lowering levels of low-density lipoprotein cholesterol (LDL-C). The impact of PCSK9 inhibition in statin-treated patients on coronary atherosclerosis had remained unknown. RECENT FINDINGS: The GLAGOV trial compared the effect of the PCSK9 inhibitor, evolocumab, and placebo on progression of coronary atherosclerosis in patients treated with at least moderate intensity statin therapy...
September 20, 2017: Current Opinion in Lipidology
https://www.readbyqxmd.com/read/28922188/new-insights-into-the-role-of-glycosylation-in-lipoprotein-metabolism
#4
Marjolein A W van den Boogert, Daniel J Rader, Adriaan G Holleboom
PURPOSE OF REVIEW: Human genetics has provided new insights into the role of protein glycosylation in regulating lipoprotein metabolism. Here we review these new developments and discuss the biological insights they provide. RECENT FINDINGS: Case descriptions of patients with congenital defects in N-glycosylation (CDG-I) frequently describe a distinct hypocholesterolemia in these rare multisystem clinical syndromes. Two novel CDGs with disturbed Golgi homeostasis and trafficking defects result in mixed glycosylation disorders, hepatic steatosis and hypercholesterolemia...
September 15, 2017: Current Opinion in Lipidology
https://www.readbyqxmd.com/read/28914630/strategies-for-the-use-of-nonstatin-therapies
#5
Angela Pirillo, Giuseppe D Norata, Alberico L Catapano
PURPOSE OF REVIEW: Dyslipidaemias are a major risk factor for cardiovascular disease (CVD); in particular, high levels of low-density lipoprotein cholesterol (LDL-C) have been associated to a higher cardiovascular risk. Reducing LDL-C levels decreases the risk of coronary heart disease (CHD), and the greater the LDL-C reduction, the greater the decrease in cardiovascular risk. Although statins represent the first line lipid-lowering therapy, many patients do not reach the recommended goals or exhibit adverse side effects leading to therapy discontinuation; in addition, a significant percentage of statin-treated patients continue to experience cardiovascular events even in the presence of well controlled LDL-C levels, because of alterations in other lipid/lipoprotein classes, including triglycerides and high-density lipoprotein cholesterol...
September 12, 2017: Current Opinion in Lipidology
https://www.readbyqxmd.com/read/28902717/new-approaches-to-address-dyslipidemia
#6
Klaus G Parhofer
PURPOSE OF REVIEW: Although lipid-lowering treatment with statins, ezetimibe, and PCSK9 inhibitors is a very successful strategy to prevent cardiovascular events, there is a need for further drug developments. Not all patients respond sufficiently to the available therapy (very high baseline values, intolerance). Furthermore, patients may be characterized by dyslipidemias not accessible to available drugs such as patients with homozygous familial hypercholesterolemia, chylomicronemia syndrome, or elevated lipoprotein(a)...
September 11, 2017: Current Opinion in Lipidology
https://www.readbyqxmd.com/read/28877089/the-maturation-of-a-neural-hematopoietic-inflammatory-axis-in-cardiovascular-disease
#7
Lotte C A Stiekema, Johan G Schnitzler, Matthias Nahrendorf, Erik S G Stroes
PURPOSE OF REVIEW: Atherogenesis is the result of a complex interplay between lipids and innate immune cells, which are descendants of upstream progenitors residing in hematopoietic organs. In this review, we will discuss recent advances in the connection between hematopoiesis and atherogenesis. RECENT FINDINGS: The relevance of a neural-hematopoietic axis was recently supported by the demonstration of a correlation between metabolic activity in the amygdala and the bone marrow...
September 4, 2017: Current Opinion in Lipidology
https://www.readbyqxmd.com/read/28858885/recent-perspectives-on-the-role-of-nutraceuticals-as-cholesterol-lowering-agents
#8
Natalie Ward, Amirhossein Sahebkar, Maciej Banach, Gerald Watts
PURPOSE OF REVIEW: Reduction in circulating cholesterol is an important step in lowering cardiovascular risk. Although statins are the most frequently prescribed cholesterol-lowering medication, there remains a significant portion of patients who require alternative treatment options. Nutraceuticals are increasingly popular as cholesterol-lowering agents. Despite the lack of long-term trials evaluating their use on cardiovascular endpoints and mortality, several studies have demonstrated their potential cholesterol-lowering effects...
August 30, 2017: Current Opinion in Lipidology
https://www.readbyqxmd.com/read/28832369/trial-designs-for-statin-muscle-intolerance
#9
Robert S Rosenson
PURPOSE OF REVIEW: This article aims to review the spectrum of statin-associated muscle symptoms (SAMS), the consequences of downtitration of statin therapy on cardiovascular events, the published trials of nonstatin therapy in patients who report SAMS, and to provide a framework for future trials in SAMS patients. RECENT FINDINGS: SAMS is reported in 10-25% of patients prescribed statin therapy; however, the few patients enrolled in randomized, double-blind, controlled clinical trials (RCTs) discontinue statin therapy due to adverse events...
August 21, 2017: Current Opinion in Lipidology
https://www.readbyqxmd.com/read/28806190/the-challenges-of-proprotein-convertase-subtilisin-kexin-9-inhibitors-for-lipid-guidelines-and-models-of-care
#10
Anthony S Wierzbicki
PURPOSE OF REVIEW: The article reviews the challenges facing cardiovascular disease (CVD) guidelines committees. RECENT FINDINGS: Clinical trials in high-risk populations have shown additional CVD event reduction with ezetimibe and proprotein convertase subtilisin-kexin-9 inhibitors. These trials recruit middle-aged secondary prevention populations, whereas increasingly the population at risk of CVD comprises the elderly in primary prevention. Some major guidelines have moved from a lipid-target to a risk-based approach...
August 12, 2017: Current Opinion in Lipidology
https://www.readbyqxmd.com/read/28759472/macrophage-complexity-in-human-atherosclerosis-opportunities-for-treatment
#11
Erik A L Biessen, Kristiaan Wouters
PURPOSE OF REVIEW: The pivotal role of macrophages in experimental atherosclerosis is firmly established, but their contribution to human disease is less well defined. In this review we have outlined the current insights on macrophage phenotypes and their presumed precursors, monocytes, in clinical atherosclerosis, and their association with disease progression. Moreover, we will assess major clinical modifiers of macrophage-mediated plaque inflammation and define the outstanding questions for further study...
July 28, 2017: Current Opinion in Lipidology
https://www.readbyqxmd.com/read/28857860/hyperlipidemia-and-cardiovascular-disease-with-focus-on-familial-hypercholesterolemia
#12
Kirsten B Holven, Stine M Ulven, Martin P Bogsrud
No abstract text is available yet for this article.
October 2017: Current Opinion in Lipidology
https://www.readbyqxmd.com/read/28857859/fatty-acids-and-macrophage-functions-an-update
#13
Charles Thomas, Louise Ménégaut, David Masson
No abstract text is available yet for this article.
October 2017: Current Opinion in Lipidology
https://www.readbyqxmd.com/read/28777110/time-to-ditch-hdl-c-as-a-measure-of-hdl-function
#14
Graziella E Ronsein, Jay W Heinecke
PURPOSE OF REVIEW: Epidemiological and clinical studies link low levels of HDL cholesterol (HDL-C) with increased risk of atherosclerotic cardiovascular disease (CVD). However, genetic polymorphisms linked to HDL-C do not associate consistently with CVD risk, and randomized clinical studies of drugs that elevate HDL-C via different mechanisms failed to reduce CVD risk in statin-treated patients with established CVD. New metrics that capture HDL's proposed cardioprotective effects are therefore urgently needed...
October 2017: Current Opinion in Lipidology
https://www.readbyqxmd.com/read/28742600/cholesterol-reduction-and-macrophage-function-role-of-paraoxonases
#15
C Roger White, G M Anantharamaiah
PURPOSE OF REVIEW: Unregulated uptake of oxidized LDL by macrophages to form foam cells is the hallmark for atherosclerosis. The paraoxonase (PON) family of enzymes plays a critical role in attenuating atherosclerotic lesion formation by hydrolyzing lipid peroxides (LOOHs) and preventing the oxidation of LDL particles and by enhancing HDL-mediated cholesterol efflux. Findings in recent years suggest novel mechanisms by which PON isoforms interact with macrophages to regulate cholesterol metabolism and cellular function...
October 2017: Current Opinion in Lipidology
https://www.readbyqxmd.com/read/28723729/wnt-signaling-in-cardiovascular-disease-opportunities-and-challenges
#16
Austin Gay, Dwight A Towler
PURPOSE OF REVIEW: Cardiometabolic diseases increasingly afflict our aging, dysmetabolic population. Complex signals regulating low-density lipoprotein receptor-related protein (LRP) and frizzled protein family members - the plasma membrane receptors for the cadre of Wnt polypeptide morphogens - contribute to the control of cardiovascular homeostasis. RECENT FINDINGS: Both canonical (β-catenin-dependent) and noncanonical (β-catenin-independent) Wnt signaling programs control vascular smooth muscle (VSM) cell phenotypic modulation in cardiometabolic disease...
October 2017: Current Opinion in Lipidology
https://www.readbyqxmd.com/read/28700381/cholesterol-a-dark-horse-in-signalling-race
#17
Dmitri Sviridov, Nigora Mukhamedova
No abstract text is available yet for this article.
August 2017: Current Opinion in Lipidology
https://www.readbyqxmd.com/read/28700380/autophagy-and-hepatic-steatosis
#18
Charles E Sparks, Janet D Sparks
No abstract text is available yet for this article.
August 2017: Current Opinion in Lipidology
https://www.readbyqxmd.com/read/28700379/optimizing-dietary-patterns-to-decrease-premature-mortality
#19
Dawn C Schwenke
No abstract text is available yet for this article.
August 2017: Current Opinion in Lipidology
https://www.readbyqxmd.com/read/28700378/editorial-introduction
#20
Paul N Durrington
No abstract text is available yet for this article.
August 2017: Current Opinion in Lipidology
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