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Current Opinion in Lipidology

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https://www.readbyqxmd.com/read/30382953/emerging-roles-of-hdl-in-immune-function
#1
Kate T Creasy, John P Kane, Mary J Malloy
No abstract text is available yet for this article.
December 2018: Current Opinion in Lipidology
https://www.readbyqxmd.com/read/30382952/atherosclerotic-cardiovascular-disease-risk-assessment-in-familial-hypercholesterolemia-does-one-size-fit-all
#2
Pedro Mata, Rodrigo Alonso, Leopoldo Pérez de Isla
PURPOSE OF REVIEW: Familial hypercholesterolemia is a frequent genetic disease associated with lifelong elevation of LDL-cholesterol and premature atherosclerotic cardiovascular disease (ASCVD). Statins are the cornerstone of treatment. However, with the introduction of novel LDL-cholesterol-lowering therapies, it is necessary to identify familial hypercholesterolemia patients presenting a significantly high residual ASCVD risk. The aim of this review is to provide an update on the recent literature concerning cardiovascular risk stratification including the role of coronary imaging...
December 2018: Current Opinion in Lipidology
https://www.readbyqxmd.com/read/30379738/unravelling-atherosclerotic-heterogeneity-by-single-cell-rna-sequencing
#3
Ian R McCracken, Richard S Taylor, Neil C Henderson, Judith C Sluimer, Andrew H Baker
No abstract text is available yet for this article.
December 2018: Current Opinion in Lipidology
https://www.readbyqxmd.com/read/30379737/mendelian-randomization-causally-link-lipoproteins-to-systemic-atherosclerosis-and-help-design-clinical-trials-for-the-future-of-lipidology
#4
Raul D Santos, Viviane Z Rocha
No abstract text is available yet for this article.
December 2018: Current Opinion in Lipidology
https://www.readbyqxmd.com/read/30325759/writing-on-the-wall-for-precision-medicine-in-the-prevention-of-atherosclerotic-cardiovascular-disease
#5
Gerald F Watts, Eric S G Stroes
No abstract text is available yet for this article.
December 2018: Current Opinion in Lipidology
https://www.readbyqxmd.com/read/30320614/colchicine-an-affordable-anti-inflammatory-agent-for-atherosclerosis
#6
Peter L Thompson, S Mark Nidorf
PURPOSE OF REVIEW: Inflammation has been shown to be central to the development and progression of atherosclerosis. Despite detailed understanding of its central role and the cellular dynamics, which contribute to atherosclerotic inflammation, there has been slow progress in finding suitable agents to treat it. The recent CANTOS trial showed that the interleukin-1β inhibitor canakinumab can improve outcomes after acute coronary syndromes. Being a monoclonal antibody, it is expensive and inconvenient to administer for long-term treatment...
December 2018: Current Opinion in Lipidology
https://www.readbyqxmd.com/read/30239352/intestinal-cholesterol-absorption
#7
Maaike Kockx, Leonard Kritharides
No abstract text is available yet for this article.
December 2018: Current Opinion in Lipidology
https://www.readbyqxmd.com/read/30234556/the-prediction-of-therapy-benefit-for-individual-cardiovascular-disease-prevention-rationale-implications-and-implementation
#8
Nicole E M Jaspers, Paul M Ridker, Jannick A N Dorresteijn, Frank L J Visseren
PURPOSE OF REVIEW: We aim to outline the importance and the clinical implications of using predicted individual therapy-benefit in making patient-centered treatment decisions in cardiovascular disease (CVD) prevention. Therapy-benefit concepts will be illustrated with examples of patients undergoing lipid management. RECENT FINDINGS: In both primary and secondary CVD prevention, the degree of variation in individual therapy-benefit is large. An individual's therapy-benefit can be estimated by combining prediction algorithms and clinical trial data...
December 2018: Current Opinion in Lipidology
https://www.readbyqxmd.com/read/30234555/rna-targeted-therapeutics-for-lipid-disorders
#9
Sotirios Tsimikas
PURPOSE OF REVIEW: To summarize recent developments in the field of RNA-directed therapeutics targeting lipid disorders that are not effectively managed. RECENT FINDINGS: Despite a number of approved therapies for lipid disorders, significant unmet needs are present in treating persistently elevated LDL-cholesterol, remnant-cholesterol, triglycerides and lipoprotein(a) [Lp(a)]. Small molecules and antibodies are effective modalities, but they are unable to adequately treat many patients with abnormal lipid parameters...
December 2018: Current Opinion in Lipidology
https://www.readbyqxmd.com/read/30234554/metabolism-the-road-to-inflammation-and-atherosclerosis
#10
Lubna Ali, Johan G Schnitzler, Jeffrey Kroon
PURPOSE OF REVIEW: Evidence accumulates suggesting that cellular metabolic alterations fuel and dictate the inflammatory state of cells. In this review, we provide an overview of the observed metabolic reprogramming in endothelial cells and innate immune cells upon interaction with modified lipoproteins, thereby contributing to the progression of atherosclerosis. RECENT FINDINGS: Inflammatory endothelial cells at sites exposed to disturbed flow patterns show increased glycolytic activity...
December 2018: Current Opinion in Lipidology
https://www.readbyqxmd.com/read/30199407/key-aspects-of-pcsk9-inhibition-beyond-ldl-lowering
#11
Stéphane Ramin-Mangata, Valentin Blanchard, Gilles Lambert
PURPOSE OF REVIEW: Our primary objective is to review the most recent findings on the biology of PCSK9 and on two key aspects of PCSK9 inhibition beyond LDL control of great clinical relevance: the regulation of lipoprotein (a) circulating levels by PCSK9 inhibitors and the putative diabetogenic effects of these novel therapies. RECENT FINDINGS: The reality of two distinct extracellular and intracellular pathways by which PCSK9 decreases the abundance of the LDLR at the surface of many cell types, most importantly hepatocytes, has recently been established...
December 2018: Current Opinion in Lipidology
https://www.readbyqxmd.com/read/30156571/sex-differences-in-metabolism-and-cardiometabolic-disorders
#12
Karthickeyan Chella Krishnan, Margarete Mehrabian, Aldons J Lusis
PURPOSE OF REVIEW: Sex differences are pervasive in metabolic and cardiovascular traits, yet they have often been ignored in human and animal model research. Sex differences can arise from reversible hormonal effects, from irreversible organizational (developmental) processes, and from gene expression differences from the X and Y chromosomes. We briefly review our current understanding of the impact of these factors in metabolic traits and disorders, with an emphasis on the recent literature...
October 2018: Current Opinion in Lipidology
https://www.readbyqxmd.com/read/30156570/lipid-driven-immunometabolic-responses-in-atherosclerosis
#13
Anton Gisterå, Daniel F J Ketelhuth
PURPOSE OF REVIEW: Atherosclerosis is a chronic inflammatory disease in which subendothelial infiltration of lipoproteins leads to inflamed lesions in arteries. Despite improvements in secondary prevention, most cardiovascular events cannot be avoided with current therapies. This review focuses on novel mechanistic insights on lipid-driven immune activation, which could pave the way for new anti-inflammatory treatments for atherosclerosis. RECENT FINDINGS: Immunometabolic interactions can shape the immune response...
October 2018: Current Opinion in Lipidology
https://www.readbyqxmd.com/read/30153136/emerging-therapeutic-potential-of-glycine-in-cardiometabolic-diseases-dual-benefits-in-lipid-and-glucose-metabolism
#14
Oren Rom, Luis Villacorta, Jifeng Zhang, Y Eugene Chen, Michael Aviram
No abstract text is available yet for this article.
October 2018: Current Opinion in Lipidology
https://www.readbyqxmd.com/read/30153135/burning-fat-to-keep-your-stem-cells-the-role-of-fatty-acid-oxidation-in-various-tissue-stem-cells
#15
Marlen Knobloch, Christian Widmann
No abstract text is available yet for this article.
October 2018: Current Opinion in Lipidology
https://www.readbyqxmd.com/read/30153134/antioxidants-and-risk-of-dementia-recent-insights-and-future-opportunities
#16
Manja Koch, Klodian Dhana, Majken K Jensen
No abstract text is available yet for this article.
October 2018: Current Opinion in Lipidology
https://www.readbyqxmd.com/read/30080704/fibroblast-growth-factor-transforming-growth-factor-beta-dialogues-endothelial-cell-to-mesenchymal-transition-and-atherosclerosis
#17
Pei-Yu Chen, Michael Simons
PURPOSE OF REVIEW: Despite much effort, atherosclerosis remains an important public health problem, leading to substantial morbidity and mortality worldwide. The purpose of this review is to provide an understanding of the role of endothelial cell fate change in atherosclerosis process. RECENT FINDINGS: Recent studies indicate that a process known as endothelial-to-mesenchymal transition (EndMT) may play an important role in atherosclerosis development. Transforming growth factor beta (TGFβ) has been shown to be an important driver of the endothelial cell phenotype transition...
October 2018: Current Opinion in Lipidology
https://www.readbyqxmd.com/read/30074493/cardiovascular-oncology-exploring-the-effects-of-targeted-cancer-therapies-on-atherosclerosis
#18
Tom T P Seijkens, Esther Lutgens
PURPOSE OF REVIEW: Targeted cancer therapies have revolutionized the treatment of cancer in the past decade, but cardiovascular toxicity is a rising problem in cancer patients. Here we discuss the effects of targeted cancer therapies on atherosclerosis. Increasing the awareness of these adverse effects will promote the development of evidence-based preventive strategies in the emerging field of cardiovascular oncology. RECENT FINDINGS: Vascular endothelial growth factor inhibitors, immunomodulatory imide drugs, tyrosine kinase inhibitors and immune checkpoint inhibitors are successfully used as treatment for many types of solid and hematologic malignancies...
October 2018: Current Opinion in Lipidology
https://www.readbyqxmd.com/read/30063471/the-potential-of-chronopharmacology-for-treatment-of-atherosclerosis
#19
Carla Winter, Oliver Soehnlein
PURPOSE OF REVIEW: Development of atherosclerosis contributes to cardiovascular diseases that still are the leading cause of mortality worldwide. Successful strategies for treating inflammatory aspects of atherosclerotic lesion development are rare. Here, we review new insights into the impact of circadian rhythmicity on atherogenesis and their potential for innovative time-optimized pharmacological treatment strategies. RECENT FINDINGS: Studies on the circadian clock revealed an extensive influence on immune cell activity...
October 2018: Current Opinion in Lipidology
https://www.readbyqxmd.com/read/30020200/metabolism-of-innate-immune-cells-impact-on-atherosclerosis
#20
Niels P Riksen, Rinke Stienstra
PURPOSE OF REVIEW: It is increasingly recognized that profound metabolic changes occur in activated myeloid cells, which shape their inflammatory phenotype and cellular functions. The purpose of this review is to summarize the accumulating evidence that major metabolic adaptations occur in monocytes and macrophages in the context of atherosclerosis ultimately modulating atherosclerotic plaque formation. RECENT FINDINGS: Plaque macrophages show a profound metabolic reprogramming which is driven by atherogenic factors in the plaque microenvironment, such as damage associated molecular patterns, modified lipoproteins, and hypoxia...
October 2018: Current Opinion in Lipidology
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