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Endocrine Pathology

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https://www.readbyqxmd.com/read/30610567/plurihormonal-pituitary-tumor-of-pit-1-and-sf-1-lineages-with-synchronous-collision-corticotroph-tumor-a-possible-stem-cell-phenomenon
#1
Karen M Tordjman, Yona Greenman, Zvi Ram, Dov Hershkovitz, Orna Aizenstein, Ofra Ariel, Sylvia L Asa
Thyrotropin (TSH)-secreting pituitary tumors are the rarest functioning pituitary tumors. Nonetheless, they are not infrequently plurihormonal, as they may express/secrete hormones made by other pituitary cells derived from the Pit-1 lineage such as growth hormone (GH), prolactin (PRL), and α-subunit (αSU). However, adrenocorticotropin (ACTH) or gonadotropin secretion by such a tumor is exceptional. Although double pituitary tumors are rare, they often combine ACTH and GH secretion. A 41-year-old presented almost 2 years after delivering her 10th child; she had thyrotoxicosis (goiter and palpitations) masquerading as autoimmune postpartum thyroiditis...
January 4, 2019: Endocrine Pathology
https://www.readbyqxmd.com/read/30610566/the-prognostic-roles-of-the-ki-67-proliferation-index-p53-expression-mitotic-index-and-radiological-tumor-invasion-in-pituitary-adenomas
#2
Rovshan Hasanov, Berna İmge Aydoğan, Saba Kiremitçi, Esra Erden, Sevim Güllü
The fourth edition of the World Health Organization (WHO) classification of pituitary tumors recommended evaluation of tumor proliferation and invasion to identify aggressiveness. We aimed to assess the prognostic roles of the Ki-67 proliferation index, mitotic index, P53 expression, and cavernous sinus invasion in pituitary adenomas (PAs). Among the 601 patients who underwent transnasal/transsphenoidal adenomectomy from 2001 to 2016, 101 patients (16.8%) who had tumors with a high (≥ 3%) Ki-67 index (group A) and a control group consisting of 43 patients with a low (< 3%) Ki 67 index who were matched for age, gender, and tumor type were included...
January 4, 2019: Endocrine Pathology
https://www.readbyqxmd.com/read/30600442/in-situ-hybridization-analysis-of-long-non-coding-rnas-malat1-and-hotair-in-gastroenteropancreatic-neuroendocrine-neoplasms
#3
Ying-Hsia Chu, Heather Hardin, Jens Eickhoff, Ricardo V Lloyd
Recent studies suggest onco-regulatory roles for two long non-coding RNAs (lncRNAs), MALAT1 and HOTAIR, in various malignancies; however, these lncRNAs have not been previously examined in neuroendocrine neoplasms (NENs) of gastroenteropancreatic origins (GEP-NENs). In this study, we evaluated the expressions and prognostic significance of MALAT1 and HOTAIR in 83 cases of GEP-NENs (60 grade 1, 17 grade 2, and 6 grade 3 tumors) diagnosed during the years 2005-2017. Expression levels of MALAT1 and HOTAIR were digitally quantitated in assembled tissue microarray slides labeled by chromogenic in situ hybridization (ISH) using InForm 1...
January 2, 2019: Endocrine Pathology
https://www.readbyqxmd.com/read/30591992/evaluation-of-167-gene-expression-classifier-gec-and-thyroseq-v2-diagnostic-accuracy-in-the-preoperative-assessment-of-indeterminate-thyroid-nodules-bivariate-hroc-meta-analysis
#4
Martyna Borowczyk, Ewelina Szczepanek-Parulska, Michał Olejarz, Barbara Więckowska, Frederik A Verburg, Szymon Dębicki, Bartłomiej Budny, Małgorzata Janicka-Jedyńska, Katarzyna Ziemnicka, Marek Ruchała
The objective of this meta-analysis was to evaluate the performance of the Gene Expression Classifier (GEC) and ThyroSeq v2 (ThyroSeq) in the preoperative diagnosis of thyroid nodules with indeterminate fine-needle aspiration biopsy results. We searched literature databases from January 2001 to April 2018. The bivariate model analysis was performed to estimate pooled sensitivity, specificity, positive likelihood ratio (LR+), negative likelihood ratio (LR-), positive predictive value (PPV), and negative predictive value (NPV)...
December 27, 2018: Endocrine Pathology
https://www.readbyqxmd.com/read/30565013/tall-cell-variant-of-papillary-thyroid-carcinoma-impact-of-change-in-who-definition-and-molecular-analysis
#5
Kristine S Wong, Sara E Higgins, Ellen Marqusee, Matthew A Nehs, Trevor Angell, Justine A Barletta
The morphologic criteria for tall cell variant (TCV) of papillary thyroid carcinoma (PTC) were modified in the 2017 WHO Classification of Tumors of Endocrine Organs, with a decrease in the requirements for both the height of cells and in the percentage of tumor demonstrating a tall cell morphology. The aim of this study was to determine if the change in criteria would result in a significant increase in the percentage of tumors that meet criteria for TCV. In addition, we evaluated the correlation between morphology, molecular alterations, and clinical behavior of TCV...
December 18, 2018: Endocrine Pathology
https://www.readbyqxmd.com/read/30523500/expression-of-insulinoma-associated-protein-1-insm1-and-orthopedia-homeobox-otp-in-tumors-with-neuroendocrine-differentiation-at-rare-sites
#6
Madhuchhanda Roy, Darya G Buehler, Ranran Zhang, Michael L Schwalbe, Rebecca M Baus, M Shahriar Salamat, Ricardo V Lloyd, Jason N Rosenbaum
Insulinoma-associated protein 1 (INSM1) and orthopedia homeobox (OTP) are transcription factors that play a critical role in neuroendocrine (NE) and neuroepithelial cell development. INSM1 has been identified in multiple tumors of NE or neuroepithelial origin, whereas OTP expression has been mainly studied in NE tumors of pulmonary origin. Expression of OTP appears to correlate with poorer prognosis in pulmonary carcinoids; however, its expression patterns in other NE/neuroepithelial tumors need further investigation...
December 6, 2018: Endocrine Pathology
https://www.readbyqxmd.com/read/30456697/neuroendocrine-liver-metastasis-a-specific-set-of-markers-to-detect-primary-tumor-sites
#7
Andreas Selberherr, Oskar Koperek, Philipp Riss, Christian Scheuba, Reto Kaderli, Aurel Perren, Bruno Niederle
The diagnosis of neuroendocrine neoplasia (NEN) is often made at an advanced stage of disease, including hepatic metastasis. At this point, the primary may still be unknown and sometimes cannot even be detected by functional imaging, especially in very small tumors of the pancreas (pan) and small intestinal (si) entities. The site of the primary may be based on biopsy specimens of the liver applying a specific set of markers. Specimens of liver metastases from 87 patients with NENs were studied. In retrospect, 50 patients had si and 37 pan NENs...
November 19, 2018: Endocrine Pathology
https://www.readbyqxmd.com/read/30443770/increased-expression-of-garp-in-papillary-thyroid-carcinoma
#8
Xiaoxu Zhang, Miao Guo, Jing Yang, Yuxiao Zheng, Yanjie Xiao, Wei Liu, Fu Ren
Regulatory T cells (Tregs) are immunosuppressive immune cells that play an important role in tumor development. Suppression of Treg function is considered to be an effective strategy for cancer therapy. Glycoprotein A repetitions predominant (GARP) has been found on the surface of activated Tregs. GARP has been recently observed in only a few solid tumors including breast, colon, lung cancers, and melanoma. However, its function in cancers remains unknown. Here, we investigated the expression of GARP in human papillary thyroid carcinoma (PTC) and its prognostic significance...
November 16, 2018: Endocrine Pathology
https://www.readbyqxmd.com/read/30421319/the-role-of-immunohistochemistry-and-molecular-analysis-of-succinate-dehydrogenase-in-the-diagnosis-of-endocrine-and-non-endocrine-tumors-and-related-syndromes
#9
REVIEW
Lindsey Oudijk, José Gaal, Ronald R de Krijger
Succinate dehydrogenase (SDH) is an enzyme complex, composed of four protein subunits, that plays a role in both the citric acid cycle and the electron transport chain. The genes for SDHA, SDHB, SDHC, and SDHD are located in the nuclear DNA, and mutations in these genes have initially been described in paragangliomas (PGL) and pheochromocytomas (PCC), which are relatively rare tumors derived from the autonomic nervous system and the adrenal medulla, respectively. Patients with SDH mutations, that are almost exclusively in the germline, are frequently affected by multiple PGL and/or PCC...
November 12, 2018: Endocrine Pathology
https://www.readbyqxmd.com/read/30413933/id-proteins-may-reduce-aggressiveness-of-thyroid-tumors
#10
Laís Helena Pereira Amaral, Natássia Elena Bufalo, Karina Colombera Peres, Icléia Siqueira Barreto, Antonio Hugo José Fróes Marques Campos, Laura Sterian Ward
ID genes have an important function in the cell cycle, and ID proteins may help identify aggressive tumors, besides being considered promising therapeutic targets. However, their role in thyroid tumors is still poorly understood. We examined ID expression and their correlation with diagnostic and prognostic features aiming to find a clinical application in differentiated thyroid carcinoma (DTC) cases. mRNA levels of ID1, ID2, ID3, and ID4 genes were quantified and their expression was observed by immunohistochemistry in 194 thyroid samples including 68 goiters, 16 follicular adenomas, 75 classic papillary thyroid carcinomas, 18 follicular variants of papillary thyroid carcinoma, 5 follicular thyroid carcinomas, and 1 anaplastic thyroid cancer, besides 11 normal thyroid tissues...
November 9, 2018: Endocrine Pathology
https://www.readbyqxmd.com/read/30367334/comparison-of-monitor-image-and-printout-image-methods-in-ki-67-scoring-of-gastroenteropancreatic-neuroendocrine-tumors
#11
Fatih Mert Dogukan, Banu Yilmaz Ozguven, Rabia Dogukan, Fevziye Kabukcuoglu
Gastroenteropancreatic neuroendocrine tumors (GEP-NET) are classified according to tumor grade. Ki-67 and mitotic count are the two determinants of this classification. Therefore, Ki-67 scoring becomes very important in classifying the patients accurately. Eye-balling, counting of cells through the microscope, automated image analysis systems, and manual counting of printed image are the four major scoring methods in use. The aim of this study is to show the agreement between monitor-image method (MIM) and printout-image method (PIM) of Ki-67 scoring...
October 26, 2018: Endocrine Pathology
https://www.readbyqxmd.com/read/30357749/endocrine-pathology-society-hubert-wolfe-award-for-2018-call-for-nominations
#12
(no author information available yet)
No abstract text is available yet for this article.
October 24, 2018: Endocrine Pathology
https://www.readbyqxmd.com/read/30361844/a-young-male-with-parafibromin-deficient-parathyroid-carcinoma-due-to-a-rare-germline-hrpt2-cdc73-mutation
#13
Alisha Kapur, Narendra Singh, Ozgur Mete, Robert A Hegele, I George Fantus
Hyperparathyroidism, commonly observed in asymptomatic middle-aged women, with mild hypercalcemia, is usually caused by a benign adenoma. Some cases present with more severe manifestation and greater hypercalcemia. Within this spectrum, several familial/genetic associations have been discovered. While the majority are caused by benign disease, adenomas, or hyperplasia, a small proportion (< 1%) are associated with malignant tumors and present with more severe symptoms. Although usually sporadic, recent reports document various gene mutations that strongly predispose to the development of parathyroid carcinoma...
December 2018: Endocrine Pathology
https://www.readbyqxmd.com/read/30315491/cytomorphological-analysis-of-thyroid-nodules-diagnosed-as-follicular-variant-of-papillary-thyroid-carcinoma-a-fine-needle-aspiration-study-of-diagnostic-clues-in-42-cases-and-the-impact-of-using-bethesda-system-in-reporting-an-institutional-experience
#14
Levent Trabzonlu, Nadir Paksoy
Follicular variant of papillary thyroid carcinoma (FVPTC) is the second most common subtype of papillary thyroid carcinoma (PTC) after classical PTC (cPTC). Follicular thyroid lesions such as follicular adenomas/carcinomas, FVPTC, and noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) pose some diagnostic challenges for FNAC. In this study, we aimed to explore whether FNAC can demonstrate diagnostic clues by re-evaluating cytology slides from histopathologically diagnosed FVPTC cases...
December 2018: Endocrine Pathology
https://www.readbyqxmd.com/read/30306386/tert-immunohistochemistry-is-a-poor-predictor-of-tert-promoter-mutations-and-gene-expression-in-follicular-thyroid-carcinoma
#15
LETTER
Johan O Paulsson, Anton Olander, Felix Haglund, Jan Zedenius, C Christofer Juhlin
No abstract text is available yet for this article.
December 2018: Endocrine Pathology
https://www.readbyqxmd.com/read/30251060/tekt4-promotes-papillary-thyroid-cancer-cell-proliferation-colony-formation-and-metastasis-through-activating-pi3k-akt-pathway
#16
Zhouci Zheng, Xiaofen Zhou, Yefeng Cai, Endong Chen, Xiaohua Zhang, Ouchen Wang, Qingxuan Wang, Haiguang Liu
Thyroid carcinoma is the most common malignancy of the endocrine system worldwide, but its molecular mechanisms remain unclear. Some diseases are associated with TEKT4 gene. However, its role in thyroid carcinoma has yet to be fully examined. This study was designed to investigate the function of TEKT4 in papillary thyroid cancer (PTC). The effect of TEKT4 on aggressive behavior of PTC cell lines, namely, TPC1 and BCPAP, transfected with small interfering RNA was identified through cell proliferation, colony formation, migration, and invasion...
December 2018: Endocrine Pathology
https://www.readbyqxmd.com/read/30238434/clinically-relevant-prognostic-parameters-in-differentiated-thyroid-carcinoma
#17
REVIEW
Tyler Janovitz, Justine A Barletta
Although differentiated thyroid carcinomas typically pursue an indolent clinical course, it is important to identify the subset of tumors that are most likely to behave aggressively so that patients with these tumors are counseled and treated appropriately. Extent of disease is fundamental to the prognostication for differentiated thyroid carcinoma; however, there are additional histologic features of the tumor separate from extent of disease that have been shown to affect clinical course. This review will start with a discussion of aggressive variants of papillary thyroid carcinoma, move to the prognostic significance of vascular invasion in follicular thyroid carcinoma, and finish with a discussion of Hürthle cell carcinoma, with an emphasis on why it is not considered a subtype of follicular thyroid carcinoma in the 2017 WHO Classification of Tumors of Endocrine Organs...
December 2018: Endocrine Pathology
https://www.readbyqxmd.com/read/30215160/synchronous-multiple-pituitary-neuroendocrine-tumors-of-different-cell-lineages
#18
Ozgur Mete, Omalkhaire M Alshaikh, Amber Cintosun, Shereen Ezzat, Sylvia L Asa
We report clinicopathological features of a large series of synchronous multiple pituitary neuroendocrine tumors (PitNETs) of different cell lineages. Retrospective review of pathology records from 2001 to 2016 identified 13 synchronous multiple PitNETs from 1055 PitNETs classified using pituitary cell-lineage transcription factors, adenohypohyseal hormones, and other biomarkers. Clinical, radiological, and histopathological features of these tumors were reviewed. The series included seven females and six males...
December 2018: Endocrine Pathology
https://www.readbyqxmd.com/read/30203321/cervical-lymph-node-fine-needle-aspiration-and-needle-wash-thyroglobulin-reflex-test-for-papillary-thyroid-carcinoma
#19
Xiaotun Zhang, Joshua M Howell, Yajue Huang
Fine-needle aspiration (FNA) cytology coupled with needle-wash thyroglobulin (FNA-Tg) testing is recommended for cervical lymph node (LN) biopsies in patients with a history of papillary thyroid carcinoma (PTC). However, the procedure has not been standardized with the assay for FNA-Tg testing. A standard operating procedure (SOP) has been generated at our facility for cervical LN FNAs with Tg reflex testing on patients with a history of PTC. The procedure requires FNA cytology to be reviewed first, and all cases not positive for PTC are reflexed for FNA-Tg testing with the Beckman Access thyroglobulin assay...
December 2018: Endocrine Pathology
https://www.readbyqxmd.com/read/30196478/papillary-thyroid-microcarcinoma-reclassification-to-non-invasive-follicular-thyroid-neoplasm-with-papillary-like-nuclear-features-niftp-a-retrospective-clinicopathologic-study
#20
Khurram Shafique, Virginia A LiVolsi, Kathleen Montone, Zubair W Baloch
Papillary thyroid microcarcinoma (PTMC) accounts for nearly 50% of newly diagnosed PTC cases. There is considerable debate in literature about the clinicopathologic features and prognostic significance of PTMC and whether it should be treated as a separate entity. Due to lack of agreement and supportive data, the consensus study group that established the criteria for non-invasive thyroid neoplasm with papillary-like features (NIFTP) kept its size above 1 cm i.e., excluding PTMC from this new group. As a result, to date, some patients diagnosed with PTMC get aggressive treatments such as partial or total thyroidectomy and even radioactive iodine ablation...
December 2018: Endocrine Pathology
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