journal
MENU ▼
Read by QxMD icon Read
search

Antiviral Chemistry & Chemotherapy

journal
https://www.readbyqxmd.com/read/29096526/establishment-of-an-antiviral-assay-system-and-identification-of-severe-fever-with-thrombocytopenia-syndrome-virus-inhibitors
#1
Masanori Baba, Masaaki Toyama, Norikazu Sakakibara, Mika Okamoto, Naomichi Arima, Masayuki Saijo
Aims Severe fever with thrombocytopenia syndrome (SFTS) is an emerging tick-borne infectious disease. SFTS is epidemic in Asia, and its fatality rate is around 30% in Japan. The causative virus severe fever with thrombocytopenia syndrome virus (SFTSV) is a phlebovirus of the family Phenuiviridae (the order Bunyavirales). Although effective treatments are required, there are no antiviral agents currently approved for clinical use. Ribavirin and favipiravir were examined for their anti-SFTSV activity and found to be selective inhibitors of SFTSV replication in vitro...
November 3, 2017: Antiviral Chemistry & Chemotherapy
https://www.readbyqxmd.com/read/29096525/nucleoside-diphosphate-and-triphosphate-prodrugs-an-unsolvable-task
#2
Chris Meier
In this review, our recent advances in the development of nucleoside di- and nucleoside triphosphate prodrugs is summarized. Previously, we had developed a successful membrane-permeable pronucleotide system for the intracellular delivery of nucleoside monophosphates as well, the so-called cycloSal-approach. In contrast to that work in which the delivery is initiated by a chemically driven hydrolysis reaction, for the di- and triphosphate delivery, an enzymatic trigger mechanism involving (carboxy)esterases had to be used...
November 3, 2017: Antiviral Chemistry & Chemotherapy
https://www.readbyqxmd.com/read/29172646/3-7-dideazaneplanocin-synthesis-and-antiviral-analysis
#3
Xue-Qiang Yin, Stewart W Schneller
Objective To synthesize 3,7-dideazaneplanocin and evaluate its antiviral potential. Methods The target 3,7-dideazaneplanocin has been prepared in five steps from a readily available cyclopentenol. A thorough in vitro antiviral analysis was conducted versus both DNA and RNA viruses. Results A rational synthesis of 3,7-dideazaneplanocin was conceived and successfully pursued in such a way that it can be adapted to various analogs of 3,7-dideazaneplanocin. Using standard antiviral assays, no activity for 3,7-dideazaneplanocn was found...
December 2017: Antiviral Chemistry & Chemotherapy
https://www.readbyqxmd.com/read/28768435/cycluridine-a-novel-antiviral-effective-against-flaviviruses
#4
REVIEW
Angel S Galabov, Lucia Mukova, Yuriy P Abashev, Lilia Wassilewa, Petko Tzvetkov, Vassil Minkov, Igor F Barinskiy, Charles M Rice, Sergey Ouzounov, Dorotea Sidzhakova
This review describes the contemporary state of research for antivirals effective against flaviviruses, especially focusing on inhibitors of the pestivirus causative agent of bovine viral diarrhoea virus. We highlight cycluridine, an originally synthesized Mannich's base [a tetrahydro-2(1H)-pyrimidinones derivative], as a highly effective antiviral possessing a strong inhibitory effect on bovine viral diarrhoea virus replication. Cycluridine was active against replication of a wide variety of bovine viral diarrhoea virus strains in cell cultures...
August 2017: Antiviral Chemistry & Chemotherapy
https://www.readbyqxmd.com/read/28768434/metabolic-reprogramming-during-hepatitis-b-disease-progression-offers-novel-diagnostic-and-therapeutic-opportunities
#5
REVIEW
Jesse Jr Masson, Hugh Ww Billings, Clovis S Palmer
Metabolic remodeling occurs in immune cells during an infection. Host cells must upregulate energy production for growth, proliferation, and effector functions to limit the damage imposed by pathogens. One example, the hepatitis B virus, induces hepatic injury in human hepatocytes through dysregulation of aerobic glycolysis and lipid metabolism. Increased glycolytic metabolism mediated by elevated expression of Glut1, glucose influx, and lactate secretion is associated with this Warburg phenotype, a classic metabolic signature also observed in cancer cells...
August 2017: Antiviral Chemistry & Chemotherapy
https://www.readbyqxmd.com/read/28768433/editorial
#6
Andrea Brancale
No abstract text is available yet for this article.
August 2017: Antiviral Chemistry & Chemotherapy
https://www.readbyqxmd.com/read/28737040/potential-of-small-molecule-fungal-metabolites-in-antiviral-chemotherapy
#7
REVIEW
Biswajit G Roy
Various viral diseases, such as acquired immunodeficiency syndrome, influenza, and hepatitis, have emerged as leading causes of human death worldwide. Scientific endeavor since invention of DNA-dependent RNA polymerase of pox virus in 1967 resulted in better understanding of virus replication and development of various novel therapeutic strategies. Despite considerable advancement in every facet of drug discovery process, development of commercially viable, safe, and effective drugs for these viruses still remains a big challenge...
August 2017: Antiviral Chemistry & Chemotherapy
https://www.readbyqxmd.com/read/28417642/equilibrative-nucleoside-transporter-1-expression-in-primary-human-hepatocytes-is-highly-variable-and-determines-uptake-of-ribavirin
#8
Kanwal Baloch, Liqiong Chen, Ameer A Memon, Laura Dexter, William Irving, Mohammad Ilyas, Brian J Thomson
Aims Ribavirin is a nucleoside analogue and remains a necessary component of both interferon-based and directly acting anti-viral regimens for the treatment of hepatitis C virus infection. The achievable concentration of ribavirin within hepatocytes is likely to be an important determinant of therapeutic outcome. In vitro expression levels of equilibrative nucleoside transporter 1 (ENT1) has been shown to be a predictor of treatment response in patients receiving nucleoside-based chemotherapeutic agents. We therefore investigated whether a similar relationship existed between ENT1 expression and ribavirin uptake in freshly isolated primary hepatocytes...
April 2017: Antiviral Chemistry & Chemotherapy
https://www.readbyqxmd.com/read/28417641/editorial-for-avcc-relaunch-issue
#9
Andrea Brancale
No abstract text is available yet for this article.
April 2017: Antiviral Chemistry & Chemotherapy
https://www.readbyqxmd.com/read/28417640/combinations-of-l-n-g-monomethyl-arginine-and-oseltamivir-against-pandemic-influenza-a-virus-infections-in-mice
#10
Donald F Smee, Ashley Dagley, E B Tarbet
L-N(G)-monomethyl-arginine (L-NMMA) is an experimental compound that suppresses nitric oxide production in animals. The compound was combined with oseltamivir to treat lethal influenza A/California/04/2009 (H1N1) pandemic virus infections in mice. Treatments were given twice a day for five days starting 4 h (oseltamivir, by oral gavage) or three days (L-NMMA, by intraperitoneal route; corresponding to the time previously reported for nitric oxide induction in the animals) after infection. Low doses of oseltamivir were used in order to demonstrate synergy or antagonism...
April 2017: Antiviral Chemistry & Chemotherapy
https://www.readbyqxmd.com/read/28893089/investigation-of-the-solvent-dependent-photolysis-of-a-nonnucleoside-reverse-transcriptase-inhibitor-antiviral-agent-efavirenz
#11
Maryam A Jordaan, Michael Shapi
This study sought to investigate the solvent-dependency on the photolysis of efavirenz to gain insight into the photoprocesses involved. The primary mechanisms were firstly the excited-state intramolecular proton transfer (i.e. phototautomerization), which generated the imidic acid phototautomer observed as [M-H](-) quasimolecular ion at m/z 314.0070 in the high-performance liquid chromatography-electrospray ionization-time-of-flight mass spectrometry in the negative mode. Secondly, the photoinduced α-cleavage with the loss of a carbonyl group occurred (i...
January 1, 2017: Antiviral Chemistry & Chemotherapy
https://www.readbyqxmd.com/read/27815332/novel-symmetrical-phenylenediamines-as-potential-anti-hepatitis-c-virus-agents
#12
Marcella Bassetto, Salvatore Ferla, Pieter Leyssen, Johan Neyts, Mark M Yerukhimovich, David N Frick, Rachel O'Donnell, Andrea Brancale
BACKGROUND: Despite the great progress made in the last 10 years, alternative strategies might help improving definitive treatment options against hepatitis C virus infection. METHODS: With the aim of identifying novel inhibitors of the hepatitis C virus-1b replication targeting the viral NS3 helicase, the structures of previously reported symmetrical inhibitors of this enzyme were rationally modified, and according to docking-based studies, four novel scaffolds were selected for synthesis and evaluation in the hepatitis C virus-1b subgenomic replicon assay...
November 4, 2016: Antiviral Chemistry & Chemotherapy
https://www.readbyqxmd.com/read/27815331/anti-enteroviral-triple-combination-of-viral-replication-inhibitors-activity-against-coxsackievirus-b1-neuroinfection-in-mice
#13
Adelina Stoyanova, Ivanka Nikolova, Gerhard Pürstinger, Georgi Dobrikov, Vladimir Dimitrov, Stefan Philipov, Angel S Galabov
BACKGROUND: Chemotherapy is an important tool for controlling enterovirus infections, but clinically effective anti-enterovirus drugs do not currently exist, mainly due to the development of drug resistance. We investigated the combination effects of enterovirus replication inhibitors in order to limit this process. In previous studies, we showed the efficacy of consecutive alternating administration of the triple combinations disoxaril/guanidine/oxoglaucine and pleconaril/guanidine/oxoglaucine against coxsackievirus B1 infection in newborn mice...
November 4, 2016: Antiviral Chemistry & Chemotherapy
https://www.readbyqxmd.com/read/27620888/effect-of-sialidase-fusion-protein-das-181-on-human-metapneumovirus-infection-of-hep-2-cells
#14
Sutthiwan Thammawat, Tania A Sadlon, Penelope Adamson, David L Gordon
Human metapneumovirus is an emerging cause of lower respiratory disease in infants, young children, and immunocompromised adults. We have previously demonstrated that human metapneumovirus infection is mediated by interaction of human metapneumovirus attachment (G) and/or fusion (F) proteins with cellular glycosaminoglycans. We report here the activity of an investigational sialidase fusion protein, DAS181, on human metapneumovirus infection of Hep-2 cells. These results suggest that human metapneumovirus infection may involve sialic acids, providing a new therapeutic strategy for human metapneumovirus for which there is currently no available treatment...
September 12, 2016: Antiviral Chemistry & Chemotherapy
https://www.readbyqxmd.com/read/27503576/isolation-and-characterization-of-hepatitis-c-virus-resistant-to-a-novel-phenanthridinone-derivative
#15
Wataru Ito, Masaaki Toyama, Mika Okamoto, Masanori Ikeda, Koichi Watashi, Takaji Wakita, Yuichi Hashimoto, Masanori Baba
BACKGROUND: The novel phenanthridinone derivative HA-719 has recently been identified as a highly potent and selective inhibitor of hepatitis C virus replication. To elucidate its mechanism of inhibition, we have isolated and analyzed a clone of hepatitis C virus replicon cells resistant to HA-719. METHODS: To isolate HA-719-resistant replicon cells, Huh-7 cells containing subgenomic hepatitis C virus replicons (genotype 1b) with a luciferase reporter (LucNeo#2) were cultured in the presence of G418 and escalating concentrations of HA-719...
August 8, 2016: Antiviral Chemistry & Chemotherapy
https://www.readbyqxmd.com/read/27503577/melatonin-decreases-brain-apoptosis-oxidative-stress-and-cd200-expression-and-increased-survival-rate-in-mice-infected-by-venezuelan-equine-encephalitis-virus
#16
Milagros Montiel, Ernesto Bonilla, Nereida Valero, Jesús Mosquera, Luz M Espina, Yasmir Quiroz, Melchor Álvarez-Mon
BACKGROUND: Pro-inflammatory and oxidative events during brain Venezuelan equine encephalitis virus infection could lead to apoptosis and induce anti-inflammatory responses (increased expression of CD200). The aim of this study was to determine the effect of melatonin on brain apoptosis, oxidative stress, and CD200 molecule in mice and neuroblastoma cultures infected by Venezuelan equine encephalitis virus. METHODS: Mice were infected with 10 median lethal doses (LD50) of Venezuelan equine encephalitis virus, treated with melatonin (500 µg/kg bw; three days before infection and during all experimental time) and sacrificed on days 1, 3, and 5 postinfection...
August 2015: Antiviral Chemistry & Chemotherapy
https://www.readbyqxmd.com/read/27341844/combination-activity-of-neuraminidase-inhibitor-oseltamivir-and-%C3%AE-tocopherol-in-influenza-virus-a-h3n2-infection-in-mice
#17
Angel S Galabov, Milka Mileva, Lora Simeonova, Galina Gegova
BACKGROUND: Influenza is a highly contagious viral infection of the respiratory system. To attack two processes involved in flu pathogenesis-viral replication in the infected body and oxidative damages, we studied the combination effect of neuraminidase inhibitor oseltamivir and antioxidant α-tocopherol in experimental model of influenza. METHODS: After inoculation of albino mice with 10 MLD50 (50% mouse lethal dose) of influenza virus A/Aichi/2/68 (H3N2), oseltamivir was applied orally at three doses, 2...
August 2015: Antiviral Chemistry & Chemotherapy
https://www.readbyqxmd.com/read/27296393/predicting-zika-virus-structural-biology-challenges-and-opportunities-for-intervention
#18
Bryan D Cox, Richard A Stanton, Raymond F Schinazi
BACKGROUND: Zika virus is an emerging crisis as infection is implicated in severe neurological disorders-Guillain-Barré syndrome and fetal microcephaly. There are currently no treatment options available for Zika virus infection. This virus is part of the flavivirus genus and closely related to Dengue Fever Virus, West Nile Virus, and Japanese Encephalitis Virus. Like other flaviviruses, the Zika virus genome encodes three structural proteins (capsid, precursor membrane, and envelope) and seven nonstructural proteins (NS1, NS2A, NS2B, NS3, NS4A, NS4B, and NS5)...
August 2015: Antiviral Chemistry & Chemotherapy
https://www.readbyqxmd.com/read/27022094/derivatives-of-usnic-acid-inhibit-broad-range-of-influenza-viruses-and-protect-mice-from-lethal-influenza-infection
#19
A A Shtro, V V Zarubaev, O A Luzina, D N Sokolov, N F Salakhutdinov
BACKGROUND: Influenza is a disease of significant morbidity and mortality, the number of anti-influenza drugs is small; many of them stimulate the appearance of resistant strains. In this work, we demonstrate activity of some usnic acid (UA) derivatives against influenza virus in vitro and in vivo. METHODS: Organic synthesis was used to prepare compounds. Antiviral activity of the compounds in vitro was evaluated by their ability to decrease the virus titer on Madin-Darby Canine Kidney cells...
August 2015: Antiviral Chemistry & Chemotherapy
https://www.readbyqxmd.com/read/26759268/molecular-basis-of-influenza-hemagglutinin-inhibition-with-an-entry-blocker-peptide-by-computational-docking-and-mass-spectrometry
#20
Robert Lu, Patrick Müller, Kevin M Downard
BACKGROUND: The increased resistance of circulating strains to current antiviral inhibitors of the influenza virus necessitates that new antivirals and their mode of action are identified. Influenza hemagglutinin is an ideal target given inhibitors of its function can block the entry of the virus into host cells during the early stages of replication. This article describes the molecular basis for the inhibition of H1 and H5 hemagglutinin by an entry-blocker peptide using companion molecular docking and mass spectrometry-based experiments...
August 2015: Antiviral Chemistry & Chemotherapy
journal
journal
30471
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"