journal
MENU ▼
Read by QxMD icon Read
search

Pathobiology: Journal of Immunopathology, Molecular and Cellular Biology

journal
https://www.readbyqxmd.com/read/30227408/clinical-implication-of-multi-parameter-flow-cytometry-in-myelodysplastic-syndromes
#1
REVIEW
Carolien Duetz, Theresia M Westers, Arjan A van de Loosdrecht
Myelodysplastic syndromes (MDS) are a challenging group of diseases for clinicians and researchers, as both disease course and pathobiology are highly heterogeneous. In (suspected) MDS patients, multi-parameter flow cytometry can aid in establishing diagnosis, risk stratification and choice of therapy. This review addresses the developments and future directions of multi-parameter flow cytometry scores in MDS. Additionally, we propose an integrated diagnostic algorithm for suspected MDS.
September 18, 2018: Pathobiology: Journal of Immunopathology, Molecular and Cellular Biology
https://www.readbyqxmd.com/read/30227407/early-loss-of-forkhead-transcription-factor-o-subgroup-member-1-protein-in-the-development-of-pancreatic-ductal-adenocarcinoma
#2
Wael Al-Zoughbi, Silvia Schauer, Martin Pichler, Gerald Hoefler
OBJECTIVES: Forkhead transcription factor, O subgroup, member 1 (FOXO1) is a regulatory protein that plays an essential role in cellular homeostasis. A biological function as a tumor suppressor has been proposed. Here, we examined FOXO1 expression in human pancreatic ductal adenocarcinoma (PDAC) and its precursor lesions. METHODS: We immunohistochemically labeled tissue samples from 47 patients with PDAC for FOXO1 protein. In addition, we extracted data from the Cancer Genome Atlas and the Cancer Cell Line Encyclopedia and studied a potential association with well-established genetic variants...
September 18, 2018: Pathobiology: Journal of Immunopathology, Molecular and Cellular Biology
https://www.readbyqxmd.com/read/30223275/proliferation-potential-related-protein-promotes-the-esophageal-cancer-cell-proliferation-migration-and-suppresses-apoptosis-by-mediating-the-expression-of-p53-and-interleukin-17
#3
Fei Ye, Jizhong Song, Yetao Wang, Xuemei Xu, Kaiguang Zhang
OBJECTIVE: This study aims to investigate the mechanism of proliferation potential-related protein (PP-RP) in influencing the proliferation, migration, and apoptosis of esophageal cancer cells. METHODS: Quantitative real-time PCR and western blotting were performed to analyze the expression of PP-RP gene, p53, and interleukin (IL)-17 in human normal tissues and tumor tissues, as well as the expression of p53 and IL-17 in Eca109 and TE3 cells. The esophageal cancer cell proliferation was detected by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT), cell apoptosis was detected by flow cytometry, and cell migration was detected by transwell migration...
September 17, 2018: Pathobiology: Journal of Immunopathology, Molecular and Cellular Biology
https://www.readbyqxmd.com/read/30223270/differential-expression-of-cancer-associated-fibroblast-related-proteins-in-ductal-carcinoma-in-situ-according-to-molecular-subtype-and-stromal-histology
#4
Ji Hee Lee, Hye Min Kim, Ja Seung Koo
OBJECTIVE: The purpose of this study is to investigate the expression of cancer-associated fibroblast (CAF)-related proteins and their implication in ductal carcinoma in situ (DCIS). METHODS: We constructed a tissue microarray of 223 cases of DCIS and examined immunohistochemical staining for the 7 CAF-related proteins. We classified DCIS into luminal type, human epidermal growth factor receptor-2 (HER-2) type, and triple negative breast cancer (TNBC) according to the immunohistochemical results for estrogen receptor, progesterone receptor, and HER-2...
September 17, 2018: Pathobiology: Journal of Immunopathology, Molecular and Cellular Biology
https://www.readbyqxmd.com/read/30223268/airway-centered-pleuroparenchymal-fibroelastosis-associated-with-non-necrotizing-granulomas-a-rare-new-entity
#5
Elena Bargagli, Paola Rottoli, Elena Torricelli, Chiara Allegrini, Alessandra Dubini, David Bennett, Luca Luzzi, Donatella Spina, Venerino Poletti, Sara Tomassetti
Pleuroparenchymal fibroelastosis is a rare form of upper-lobe-dominant progressive pulmonary fibrosis characterized histologically by visceral pleural thickening with collagenous fibrosis, subpleural elastosis, and intra-alveolar collagenous fibrosis. It was first described 25 years ago by Amitani et al. This report firstly describes a new variant or rare phenotype of PPFE with airway involvement, minimal pleuroparenchymal connections, and non-necrotizing granulomas.
September 17, 2018: Pathobiology: Journal of Immunopathology, Molecular and Cellular Biology
https://www.readbyqxmd.com/read/30223266/immunohistochemical-and-molecular-analyses-focusing-on-mesenchymal-cells-in-papillary-thyroid-carcinoma-with-desmoid-type-fibromatosis
#6
Nami Takada, Zhanna Mussazhanova, Mitsuyoshi Hirokawa, Masahiro Nakashima, Akira Miyauchi
OBJECTIVE: This study was designed to evaluate the prevalence of CTNNB1 (β-catenin) mutations in cases of papillary thyroid carcinoma with desmoid-type fibromatosis (PTC-DTF) expressing aberrant nuclear and cytoplasmic immunoreactivity for β-catenin. METHODS: Eight cases of PTC-DTF were available for this study. Immunohistochemistry for β-catenin and BRAFV600E was performed. CTNNB1 and BRAFV600E mutations were also evaluated by direct sequencing. RESULTS: For β-catenin, although we could demonstrate aberrant nuclear and cytoplasmic immunoreactivity in DTF components in all cases, suggesting activated Wnt signaling, direct sequencing revealed a missense mutation, c...
September 17, 2018: Pathobiology: Journal of Immunopathology, Molecular and Cellular Biology
https://www.readbyqxmd.com/read/30223259/metastatic-prostate-carcinoma-from-imperial-rome-1st-to-2nd-centuries-ad
#7
Simona Minozzi, Agata Lunardini, Carla Caldarini, Davide Caramella, Gino Fornaciari, Paola Catalano, Valentina Giuffra
OBJECTIVE: This study describes and discusses a rare case of metastatic carcinoma that affected the skeleton of an adult male recovered in the necropolis of Casal Bertone in Rome (Italy). The necropolis, which dates back to the Imperial Age (1st to 2nd century AD), is located near some residential structures and a large place identified as a fullery (fullonica). METHODS: Anthropological and paleopathological studies of the skeletal remains were performed via careful macroscopic, microscopic, radiological (X-ray and CT scan), and histological investigation...
September 17, 2018: Pathobiology: Journal of Immunopathology, Molecular and Cellular Biology
https://www.readbyqxmd.com/read/30223255/congenital-pouch-colon-role-of-genetics-or-environmental-influence
#8
Praveen Mathur, Vandana Nunia, Rakesh Sharma, Anita Simlot, Krishna Mohan Medicherla
BACKGROUND: Congenital pouch colon (CPC), a high type of anorectal malformation, is a sporadic disease and several environmental factors are known to be involved in its pathology. To the best of our knowledge, no familial incidence of CPC has been reported anywhere in the literature so far. AIM: In the present study, which is first of its kind, we have reported the familial incidences of CPC and also tried to elucidate the role of genetics in this pathology. METHODS: We have reported 1 familial pedigree of CPC and 2 incidences of dizygotic twins (DZ), out of them one is affected and another one is normal...
September 17, 2018: Pathobiology: Journal of Immunopathology, Molecular and Cellular Biology
https://www.readbyqxmd.com/read/30130765/egyptian-canopic-jars-at-the-crossroad-of-medicine-and-archaeology-overview-of-100-years-of-research-and-future-scientific-expectations
#9
REVIEW
Sidney Senti, Michael E Habicht, Enrique Rayo, Patrick E Eppenberger, Frank J Rühli, Francesco M Galassi
Ancient Egyptian human remains have been of interest in the fields of both medical and Egyptological research for decades. However, canopic jar holders for internal organs (liver, lungs, stomach, intestines) of Egyptian mummies appear to be but a very occasional source of data for such investigations. The few medical approaches focusing on the content of these jars are summarized and listed according to pathogens and diseases to give a structured overview of this field of study. An extensive search of the literature has been conducted from different bibliographic databases with a total of n = 26 studies found...
August 21, 2018: Pathobiology: Journal of Immunopathology, Molecular and Cellular Biology
https://www.readbyqxmd.com/read/30078017/baiba-attenuates-the-expression-of-inflammatory-cytokines-and-attachment-molecules-and-er-stress-in-huvecs-and-thp-1-cells
#10
Wonjae Lee, Subin Yun, Geum Hee Choi, Tae Woo Jung
OBJECTIVE: β-Aminoisobutyric acid (BAIBA), a myokine, is a thymine catabolite that is induced during exercise, leading to browning of white fat, hepatic fatty acid oxidation, and suppression of hepatic lipogenesis. However, the effects of BAIBA on the progression of atherosclerosis remain unclear. METHODS: We performed a Western blot analyses to determine various protein expression. ELISAs (enzyme-linked immunosorbent assays), cell adhesion assays, and cell viability assays were also performed on human umbilical vascular endothelial cells (HUVECs) and human monocytes (THP-1 cells)...
August 3, 2018: Pathobiology: Journal of Immunopathology, Molecular and Cellular Biology
https://www.readbyqxmd.com/read/30048985/myeloid-neoplasms-with-germline-predisposition
#11
REVIEW
Julia T Geyer
The updated 2016 WHO classification of hematopoietic tumors has a new category: "myeloid neoplasms with germline predisposition." These entities are rare, but are also currently underdiagnosed and underreported. Recognition is critical for appropriate clinical evaluation and therapy, with potential implications for the patient's entire family. The WHO includes 3 categories of myeloid neoplasms with germline predisposition: neoplasms without preexisting conditions, neoplasms with a history of thrombocytopenia, and neoplasms with other organ dysfunction...
July 26, 2018: Pathobiology: Journal of Immunopathology, Molecular and Cellular Biology
https://www.readbyqxmd.com/read/30041243/myelodysplastic-syndrome-updated
#12
REVIEW
Robert P Hasserjian
This review highlights the main changes in the revised 2016 WHO Classification of Myeloid Neoplasms (published in 2017) that impact the diagnosis and management of patients with myelodysplastic syndrome (MDS). The revision was based on data accumulated since the 2008 WHO classification of MDS, much of which relates to new molecular genetic information about these neoplasms. The new information has led to some reorganization of the MDS disease categories, including a broadening of the subset of cases classified as MDS with ring sideroblasts, many of which have mutations in the spliceosome gene SF3B1...
July 24, 2018: Pathobiology: Journal of Immunopathology, Molecular and Cellular Biology
https://www.readbyqxmd.com/read/29982244/challenges-in-diagnosing-myelodysplastic-syndromes-in-the-era-of-genetic-testing-proceedings-of-the-13th-workshop-of-the-european-bone-marrow-working-group
#13
Konnie M Hebeda, Alexandar Tzankov, Ludmila Boudova, Leonie Saft, Rob P Hasserjian, Mirthe de Boer, Falko Fend, Attilio Orazi, Roos Leguit
The 13th workshop of the European Bone Marrow Working Group in Utrecht, The Netherlands, was devoted to studying myelodysplastic syndromes (MDS) and their boundaries. The panel received 44 cases submitted to the 3 invited categories, which included: reactive cytopenias with dysplasia, idiopathic cytopenia of undetermined significance, clonal haematopoiesis of indeterminate potential, idiopathic dysplasia of uncertain significance and overt MDS. For this summary, we have selected 17 cases that highlight difficulties in separating true MDS from other causes of cytopenia and the intricate relationship between clonal haematopoiesis and true MDS...
July 6, 2018: Pathobiology: Journal of Immunopathology, Molecular and Cellular Biology
https://www.readbyqxmd.com/read/29961056/the-diagnostic-work-up-of-hypereosinophilia
#14
REVIEW
Sa A Wang
Hypereosinophilia (HE) is defined as a persistent elevated eosinophil count of ≥1.5 × 109/L. HE can be one of the dominant manifestations of a hematopoietic myeloid neoplasm or secondary/reactive to an underlying medical condition. If a cause of HE and its associated tissue/organ damage is not determined, the condition is considered to be idiopathic hypereosinophilic syndrome (HES). The work-up of HE can be challenging due to a broad range of causes of HE that can be either reactive or neoplastic. In recent years, with the advent of molecular genetic testing and the introduction of targeted therapy in the management of these patients, there is a growing interest in better characterization of these diseases...
June 29, 2018: Pathobiology: Journal of Immunopathology, Molecular and Cellular Biology
https://www.readbyqxmd.com/read/29860246/icus-idus-chip-and-ccus-diagnostic-criteria-separation-from-mds-and-clinical-implications
#15
Peter Valent
Various myeloid neoplasms, including the myelodysplastic syndromes (MDS), bear a certain risk of progression to secondary acute myeloid leukemia (sAML). The evolution from low-risk to high-risk MDS and finally to sAML suggests that leukemogenesis is a multistep process. However, even before an overt neoplasm, such as an MDS, develops, "prediagnostic" clonal conditions may be identified. With the advent of large-scale genomic screens, such conditions may be detected quite frequently and early in apparently healthy individuals...
June 1, 2018: Pathobiology: Journal of Immunopathology, Molecular and Cellular Biology
https://www.readbyqxmd.com/read/29791902/the-molecular-pathology-of-myelodysplastic-syndrome
#16
Torsten Haferlach
The diagnosis and classification of myelodysplastic syndromes (MDS) are based on cytomorphology and cytogenetics (WHO classification). Prognosis is best defined by the Revised International Prognostic Scoring System (IPSS-R). In recent years, an increasing number of molecular aberrations have been discovered. They are already included in the classification (e.g., SF3B1) and, more importantly, have emerged as valuable markers for better classification, particularly for defining risk groups. Mutations in genes such as SF3B1 and IDH1/2 have already had an impact on targeted treatment approaches in MDS...
May 23, 2018: Pathobiology: Journal of Immunopathology, Molecular and Cellular Biology
https://www.readbyqxmd.com/read/29953991/breast-cancer-in-a-lagos-facility-implications-for-the-institution-of-a-cancer-screening-programme
#17
Nzechukwu Zimudo Ikeri, Olubanji Ajibola Oguntunde, Uche Igbokwe, Fatimah Biade Abdulkareem, Adekunbiola Aina Banjo
OBJECTIVE: There are significant epidemiological and biological differences between breast cancer in blacks and whites which have wide-reaching implications for the institution of an effective cancer screening programme in Nigeria. The aim of this study was to describe the clinicopathologic features of breast cancer diagnosed in our facility and to discuss their implications for cancer screening. METHODS: A retrospective review of the forms, slides, and results of breast cancer cases received in our facility over an 8-year period was carried out, as well as a systematic review of the characteristics of breast cancer in Nigeria, Africa, the US, and the UK...
2018: Pathobiology: Journal of Immunopathology, Molecular and Cellular Biology
https://www.readbyqxmd.com/read/29949804/the-72pro-variant-of-the-tumor-protein-53-is-associated-with-an-increased-breast-cancer-risk-in-the-moroccan-population
#18
Salah Eddine Ayoubi, Mohamed Elkarroumi, Meryam El Khachibi, Hind Hassani Idrissi, Hasnaa Ayoubi, Simohamed Ennachit, Mounia Arazzakou, Sellama Nadifi
BACKGROUND: The purpose of our case control study is to explore the potential association of tumor protein 53 (TP53) c.215G>C, p. (Arg72Pro) polymorphism (rs1042522) with the risk of breast cancer (BC) development in the Moroccan population. METHODS AND RESULTS: The study population consisted of 125 female patients with confirmed BC and 126 healthy controls. DNA samples were genotyped by Polymerase Chain Reaction-Restriction Fragment Length Polymorphism assay method using BstUI restriction enzyme...
2018: Pathobiology: Journal of Immunopathology, Molecular and Cellular Biology
https://www.readbyqxmd.com/read/29860247/acral-lentiginous-melanoma-is-associated-with-certain-poor-prognostic-histopathological-factors-but-may-not-be-correlated-with-nodal-involvement-recurrence-and-a-worse-survival
#19
Faruk Tas, Kayhan Erturk
BACKGROUND/AIMS: Acral lentiginous melanoma (ALM) is a small subtype of melanoma affecting Caucasians far more often than other ethnic groups, such as blacks, Hispanics, and Asians. Only a few studies have yielded controversial results on ALM so far. The aim of this study was to define the histopathological and clinical expressions of ALM and to compare them with those of non-ALM in a large group of Turkish patients from a single referral institution. METHODS: One hundred two ALM patients were analyzed retrospectively...
2018: Pathobiology: Journal of Immunopathology, Molecular and Cellular Biology
https://www.readbyqxmd.com/read/29847827/micrornas-associated-with-epithelial-mesenchymal-transition-can-be-targeted-to-inhibit-peritoneal-dissemination-of-human-scirrhous-gastric-cancers
#20
Yoshifumi Takei, Guodong Shen, Ayami Morita-Kondo, Toshifumi Hara, Keichiro Mihara, Kazuyoshi Yanagihara
OBJECTIVES: Scirrhous gastric cancers grow rapidly, and frequently invade the peritoneum. Such peritoneal dissemination properties markedly reduce patient survival. Thus, an effective means for inhibiting peritoneal dissemination is urgently required. METHODS: We previously established a cell line, HSC-58, from a scirrhous gastric cancer patient, and further successfully isolated a metastatic line, 58As9, in nude mice upon orthotopic inoculation. Using the lines, we examined the mechanism underlying peritoneal dissemination from the viewpoint of microRNA (miRNA) expression...
2018: Pathobiology: Journal of Immunopathology, Molecular and Cellular Biology
journal
journal
30444
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"