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Journal of Biomaterials Science. Polymer Edition

Cheng Zhao, Xiuwen Wu, Guopu Chen, Feng Wang, Jianan Ren
Accelerating wound healing with modified biomaterial has been an attracting field in both material science and medicine. Enhanced cell adhesion could be acquired by improving surface hydrophilicity, which contributes to accelerating wound healing. Chemical reaction has been used for surface modification, but this study used a simple and nontoxic method to improve the hydrophilicity. Polycaprolactone (PCL) scaffold has been regarded as promising material for wound healing while its surface is hydrophobic. Our study demonstrated enhanced hydrophilicity of PCL with AuNPs coating...
September 20, 2018: Journal of Biomaterials Science. Polymer Edition
Cemile Kilic Bektas, Ilgin Kimiz, Aylin Sendemir, Vasif Hasirci, Nesrin Hasirci
Treatment of chronic skin wound such as diabetic ulcers, burns, pressure wounds are challenging problems in the medical area. The aim of this study was to design a bilayer skin equivalent mimicking the natural one to be used as a tissue engineered skin graft for use in the treatments of problematic wounds, and also as a model to be used in research related to skin, such as determination of the efficacy of transdermal bioactive agents on skin cells and treatment of acute skin damages that require immediate response...
September 18, 2018: Journal of Biomaterials Science. Polymer Edition
Nicole D Sempertegui, Akshay A Narkhede, Vinoy Thomas, Shreyas S Rao
Biomaterial scaffolds have been increasingly used for tissue engineering applications as well as three dimensional (3D) cell culture models. Herein, we report a simple procedure combining compression molding, heating, and leaching methods for the fabrication of 3D micro-porous poly(ε-caprolactone) (PCL) biomaterial scaffolds. In this procedure, PCL micro particles are mixed with NaCl of defined sizes and compression molded, followed by heating and subsequent leaching of NaCl particles. This technique eliminates the gas foaming method, which is commonly used in the fabrication of PCL scaffolds...
September 15, 2018: Journal of Biomaterials Science. Polymer Edition
B N Singh, K Pramanik
The development of bone tissue construct through tissue engineering approach offers a great promise in meeting the increasing demand for repair and regeneration of damaged and/or diseased bone tissue. For the generation of bone tissue engineered construct, polymer-ceramic composite matrices with nanostructure architecture and mesenchymal stem cells (hMSCs) of human origin are of prime requirement. Keeping these in view, in the present work a novel electrospun nanofibrous silk fibroin (SF)/carboxymethyl cellulose (CMC)/nano-bioglass (nBG) composite scaffold that mimics native bone extracellular matrix with appropriate composition was designed and fabricated by free liquid surface electrospinning technique...
September 13, 2018: Journal of Biomaterials Science. Polymer Edition
Jianrong Wu, Yuancong Zhao, Jin Wang, Tianxue You, Nan Huang
Abstracts Here we report the anticoagulant property of Sulfonated Silk Fibroin (SSF) which was improved by sulfonation method. Chlorosulfonic acid was applied to modify the Silk Fibroin (SF) anticoagulant property by the preparation of the SSF. The SSF was prepared in the new technology that 50 °C, 0.2 g SF/ml chlorosulfonic acid and 15 h were optimized with the reaction temperature, special concentration ratio of the SF to the chlorosulfonic acid and the certain reaction time, respectively. Then the SF reaction solution was dialyzed, and freeze-dried to form the SSF...
September 10, 2018: Journal of Biomaterials Science. Polymer Edition
Xuelian Zhi, Pengcheng Liu, Yanmei Li, Pengfei Li, Jiang Yuan, Jiantao Lin
Keratin is a promising material for building drug carriers due to their biocompatibility, reduction sensitivity, and biodegradability. Herein, we aim to develop acid and glutathione (GSH) dual-responsive keratin-based drug carriers with a one-step strategy. Keratin/DOX complexes were first prepared by means of a simple mixing approach, followed by desolvation and crosslinking to prepare keratin-based drug loaded nanoparticles(KDNPs). The as-prepared KDNPs showed negative-charged surface and globular morphology with the diameter of ca...
September 5, 2018: Journal of Biomaterials Science. Polymer Edition
Dongping Chen, Zhaobing Su, Linsheng Weng, Longbin Cao, Can Chen, Sufen Zeng, Suzhen Zhang, Tim Wu, Qiang Hu, Jianmin Xiao
As a promising candidate, biodegradable Poly-L-lactic Acid (PLLA) has been extensively used in coronary artery stents. In our previous reports, PLLA stents implanted in porcine coronary arteries showed safety without stent thrombosis. However, inflammatory responses were observed, which needed further study. In this study, human aortic endothelial cells (HAEC) were treated with different volume percentages of extract of pre-degraded PLLA (extract of PLLA) in vitro, and the cell growth curve and morphological changes were examined...
September 3, 2018: Journal of Biomaterials Science. Polymer Edition
Chau-Minh Phan, Hendrik Walther, Richard W Smith, Donald Riederer, Charis Lau, Kathrine Osborn Lorenz, Lakshman N Subbaraman, Lyndon Jones
The traditional method to measure release of components from CLs is a vial containing a static volume of PBS (phosphate buffered saline). However, this model does not simulate physiologically relevant tear volume and natural tear flow, air exposure, and mechanical rubbing. These factors can significantly impact release kinetics. We have developed an in vitro eye model (OcuFlow) that simulates these parameters. The aim of the study was to measure the release of PEG (polyethylene glycol), and HPMC (hydroxypropyl methylcellulose) from a daily disposable hydrogel contact lens material (nelfilcon A; Dailies AquaComfort PLUS; DACP;) over 24 hrs using the OcuFlow platform...
August 29, 2018: Journal of Biomaterials Science. Polymer Edition
Min Lai, Xufeng Yan, Ziyang Jin
The aim of this study was to enhance cytocompatibility of titanium substrates by loading a multilayer film of chitosan (Chi), gelatin (Gel) and simvastatin (SV). This was fabricated using a spin-assisted layer-by-layer (LBL) technique. The surface properties of the different substrates were characterized by field emission scanning electron microscopy (FE-SEM), atomic force microscope (AFM), X-ray photoelectron spectroscopy (XPS) and contact angle measurement, respectively. Simvastatin release in vitro was measured by ultraviolet-visible spectrophotometer...
August 29, 2018: Journal of Biomaterials Science. Polymer Edition
Pornkawee Charoenlarp, Arun Kumar Rajendran, Rie Fujihara, Taisei Kojima, Ken-Ichi Nakahama, Yoshihiro Sasaki, Kazunari Akiyoshi, Masaki Takechi, Sachiko Iseki
Different approaches have been developed to improve the scaffold properties that provide structural support and biological interaction to achieve the desired environment for tissue regeneration. We previously reported that addition of human fibroblast growth factor 18 (hFGF18) to acryloyl group-modified cholesterol-bearing pullulan (CHPOA) nanogel-crosslinked (NanoClik) hydrogels that contain human bone morphogenetic protein 2 (hBMP2) stabilized bone healing in mouse calvarial defect model. In this study, we evaluated the use of disc-shaped dried nanogel-crosslinked gel as carriers of growth factors in order to seek possible clinical application in future...
August 29, 2018: Journal of Biomaterials Science. Polymer Edition
Lin Wang, Ganggang Yang, Hua Xie, Fang Chen
Ureteral stents are commonly used in urological practices but are frequently associated with patient discomfort, encrustation and stent-related infection. And a second procedure is needed to remove the stent. New biomaterials and designs have been attempted to solve these problems. The development of biodegradable ureteral stent shows promising prospects in future clinical applications. This article reviews the biomaterials and preparation methods commonly used in the present study of biodegradable ureteral stents...
August 24, 2018: Journal of Biomaterials Science. Polymer Edition
Chao Zhou, Hongqin Song, JiaLingCelestine Loh, Jueqin She, Linhong Deng, Liu Bo
Catheters are widely used and play an important role in medicine. However, catheter-associated infection is prevalent even under stringent sterile conditions. Biofilms are formed when bacteria populate the surfaces of catheters. This makes the biofilm resistant to antibiotics. Hence, it is imperative for there to be an inherently antifouling and anti-bacterial catheter to mitigate the formation of biofilm. This paper aims to outline the synthesis of non-leachable anti-biofilm and anti-bacterial cationic film coatings through direct polymerization using supplemental activator and reducing agent surface initiated atom transfer radical polymerization (SARA SI-ATRP)...
August 24, 2018: Journal of Biomaterials Science. Polymer Edition
Yongli Shi, Jintao Xue, Zhaojie Liu, Mengjiao Du, Lanting Xu, Qianqian Sun, Zhaomin Liu, Qing Shang
In this study, a novel chitosan (CS)-modified nanoparticles (NPs) were developed to orally deliver tolbutamide (TOL). Methoxy poly(ethylene glycol)- b-poly(ε-caprolactone) carboxylates (mPEG2000 -b-PCL4000 ) was synthesized via an esterification reaction. CS-modified mPEG2000 -b-PCL4000 -COOH NPs (CS@NPs) were fabricated by injecting mPEG2000 -b-PCL4000 -COOH NPs suspension (1.0 mg/mL) into CS solution (1.0 mg/mL, pH 5.0). Fourier transform infrared spectroscopy (FTIR) spectra were used to confirm the obtaining of mPEG2000 -b-PCL4000 -COOH...
August 24, 2018: Journal of Biomaterials Science. Polymer Edition
Di Zhang, Jingang Qi, Sifan Qiao, Liang Liu, Bing Wang, Zuofu Zhao
Carbon fiber-reinforced polylactic acid (C/PLA) composites are a human bone-fixation material, but control of the material's degradation remains a major factor hindering its widespread use. In this study, a combined method for controlling the degradation performance in vitro of C/PLA composites was designed. In this strategy, carbon fibers for C/PLA composite reinforcement were prepared in both modified and unmodified forms. A pulsed electromagnetic field (PEF) was then selectively applied during the subsequent degradation process...
August 24, 2018: Journal of Biomaterials Science. Polymer Edition
Fangjun Teng, Huifen Ding, Yiqing Huang, Jiawei Wang
Abstrsct Electrospun nanofibers have been considered to be an ideal scaffold for tissue engineering, because of the extracellular-matrix-like structure and the well-controlled fabrication. Here, a new method was used to fabricate electrospun three-dimensional macroporous nanofibrous gelatin scaffolds in ethanol bath by one-step crosslink with glutaraldehyde. The mean diameter of the one-step crosslinked fibers was significantly smaller than that of the traditional two-step crosslinked fibers (P < 0.05), and scaffolds prepared by one-step crosslink were fluffy and porous...
August 22, 2018: Journal of Biomaterials Science. Polymer Edition
Hong-Ru Lin, Yan-Ting Chen, Yu-Chun Wu, Yiu-Jiuan Lin
A novel anti-hepatoma drug release hybrid system is prepared by using poly(acrylic acid) (PAA) and glycol chitin as substrate in combination with Paclitaxel (PTX)-loaded bio-biofunctionalized poly(lactic-co-glycolic acid) (PLGA) micro-particles, which is intended for cancer therapy through intratumoral injection. The rheological behavior of glycol chitin (7 wt%)/PAA illustrates that it has low gelling temperature (i.e. 17°C at pH 7.56) which ensures that the formulation turns to gel at physiological condition...
August 8, 2018: Journal of Biomaterials Science. Polymer Edition
Peiqing Liang, Junjiong Zheng, Zhaoqing Zhang, Yulin Hou, Jiayu Wang, Chao Zhang, Changyun Quan
Being an active scaffold in bone tissue engineering, hydrogel self-assembled from biomimetic peptide amphiphile (PA) has excellent ability to induce osteogenic differentiation and osteogenesis. Here, a multifunctional scaffold based on bone morphogenetic protein-2 (BMP-2) mimicking peptide, RGDS, and phosphoserine has been developed to enhance osteogenesis. Cell experiments in vitro displayed that the hydrogel could effectively promote rat messenchymal stem cells (rMSCs) proliferation and induce them differentiation into oesteblasts...
August 8, 2018: Journal of Biomaterials Science. Polymer Edition
Zhimei Wei, Chen Xiong, Zhenyan Liu, Xiaojun Wang, Shengru Long, Jie Yang
Polymeric porous ultrafine fibers with different structures as drug carrier could be facilely prepared. However, the drug release characteristics and relevant mechanism of different structural porous ultrafine fibers were not well studied. In the present work, different structural polyethersulfone (PES) based porous ultrafine fibers, namely PES, PES/Polyethyleneglycol (PEG) and PES/Water were prepared by electrospinning. Curcumin was chosen as drug model loaded in these fibers. Investigation of curcumin release characteristics was carried out by the total immersion in buffer solution...
August 1, 2018: Journal of Biomaterials Science. Polymer Edition
Somayyeh Fallah Iri Sofla, Mojtaba Abbasian, Mortaza Mirzaei
Currently an effective strategy in nanomedicine for cancer therapy is the combination of photothermal therapy with chemotherapy. Because combination cancer therapy improve the therapy efficiency by synergistic effects and overcoming drug resistance as compared to monotherapy possesses. According to these facts, gold nanorods-cored biodegradable micelles were prepared by coating gold nanorods (AuNRs) with synthesized pH-sensitive thiol-ended amphiphilic triblock copolymer (PAA-b-PDMAEMAQ-b-PCL-SH). The synthesized AuNRs@polymer was loaded with methotrexate (MTX) as an anticancer drug through electrostatic interactions to afford AuNRs@polymer-MTX...
July 23, 2018: Journal of Biomaterials Science. Polymer Edition
Xiuzhen Wan, Yanfang Wang, Xingxing Jin, Pengfei Li, Jiang Yuan, Jian Shen
Heparins are capable of improving blood compatibility, enhancing HUVEC viability, while inhibiting HUASMC proliferation. Combination of biodegradable poly(ε-caprolactone)(PCL) with keratin and heparins would provide an anticoagulant and endothelialization supporting environment for vascular tissue engineering. Herein, PCL and keratin were first coelectrospun and then covalently conjugated with heparins. The resulting mats were surface-characterized by ATR-FTIR, SEM, WCA, and XPS. Cell viability data showed that the heparinized PCL/keratin mats could motivate the adhesion and growth of HUVEC, while inhibit HUASMC proliferation...
July 23, 2018: Journal of Biomaterials Science. Polymer Edition
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