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Journal of Biomaterials Science. Polymer Edition

Bushra Iqbal, Zenab Sarfaraz, Nawshad Muhammad, Pervaiz Ahmad, Jibran Iqbal, Zia Ul Haq Khan, Girma Gonfa, Farasat Iqbal, Arshad Jamal, Abdur Rahim
In this study, collagen/alginate/hydroxyapatite beads having different proportions were prepared as bone fillers for the restoration of osteological defects. Ionic liquid was used to dissolve the collagen and subsequently the solution was mixed with sodium alginate solution. Hydroxyapatite was added in different proportions, with the rationale to enhance mechanical as well as biological properties. The prepared solutions were given characteristic bead shapes by dropwise addition into calcium chloride solution...
February 20, 2018: Journal of Biomaterials Science. Polymer Edition
Wenchao Li, Yiqiang Hu, Lei Shi, Xianglin Zhang, Liming Xiong, Wancheng Zhang, Ismat Ullah
The Polycaprolactone (PCL) fibrous scaffolds in nano to micro scale have been considered as excellent templates for cell culture and tissue growth. The hydrophobic nature of the PCL, however, yields low initial cell seeding density, heterogeneous cell spreading and slow cell growth rate. Therefore, in this study the surface hydrophilic fibrous scaffolds were directly fabricated by the electrospinning of PCL solutions with small quantities (0.5~5%) of Pluronic F127 (PEO100 -PPO65 -PEO100 ) dissolved in benign solvent of glacial acetic acid...
February 19, 2018: Journal of Biomaterials Science. Polymer Edition
Jaeyong Song, Junhyung Kim, Heung-Myung Woo, Byungil Yoon, Hyunjung Park, Chanhum Park, Byung-Jae Kang
Our study aimed to investigate the effect of bone morphogenetic protein-2 (BMP-2) bound to silk fibroin and β-tricalcium phosphate (SF/β-TCP) hybrid on the healing of critical-size radial defects in rabbits. A 15-mm critical-size defect was induced at mid-diaphysis in the left radius of 20 New Zealand white rabbits (average age, 3.5 months; weight, 2.5-3.0 kg). The animals were randomized into Group 1 (SF/β-TCP combined with BMP-2), Group 2 (SF/β-TCP alone), and Group 3 (nothing implanted). Radiographs were obtained every 2 weeks and euthanasia was performed after 8 weeks for visual, radiological, micro-computed tomography (micro-CT), and histological studies...
February 6, 2018: Journal of Biomaterials Science. Polymer Edition
Sherif Ramadan, Narinder Paul, Hani E Naguib
A simple myocardial analogue material has great potential to help researchers in the creation of medical CT Imaging phantoms. This work aims to outline a Bis(2-ethylhexyl) phthalate (DEHP) plasticizer/PVC material to achieve this. DEHP-PVC was manufactured in three ratios, 75%, 80%, and 85% DEHP by heating at 110°C for 10 minutes to promote DEHP-PVC binding followed by heating at 150°C to melt the blend. The material was then tested utilizing FTIR, tensile testing, dynamic mechanical analysis and imaged with computed tomography...
February 5, 2018: Journal of Biomaterials Science. Polymer Edition
Tooru Ooya, Takaya Ogawa, Toshifumi Takeuchi
Enzyme application has gained importance over the past decade in bioprocess, biomedical, and pharmaceutical fields. We found that polyglycerol dendrimers (PGDs), which are biocompatible molecules, can recover alcohol dehydrogenase (ADH) from aqueous solution under elevated temperature. A low concentration of PGD (5 wt.%) is sufficient for the recovery of high enzymatic activity, although a high concentration (25-75 wt.%) of glycerol is generally required to stabilize ADH. The enzymatic activity of ADH in suspension with PGDs is over 60% but it is only 10% in that with glycerol...
February 1, 2018: Journal of Biomaterials Science. Polymer Edition
Md Ariful Islam Sarker, Mohammad Izadifar, David Schreyer, Xiongbiao Chen
Three dimensional (3D) bioplotting requires appropriate crosslinkers to crosslink the hydrogel precursor while simultaneously maintaining the viability of embedded cells. However, the evaluation and comparison of various types of crosslinkers in bioplotting remains underexplored to date. This paper presents our study of the influence of three ionic crosslinkers-calcium chloride (CaCl2), barium chloride (BaCl2), and zinc chloride (ZnCl2)-on the mechanical and biological properties of 3D bioplotted alginate scaffolds...
January 29, 2018: Journal of Biomaterials Science. Polymer Edition
Liping Zhang, Luyan Wu, Gang Shi, Xinxin Sang, Caihua Ni
The enhancement of tumor intracellular drug uptake and resistance against nonspecific protein adsorption are essential for an injectable anticancer drug carrier. In the present study, a new type of redox/pH-responsive zwitterionic nanoparticles (NPs) was prepared using poly-L-glutamic acid (PLG) and cystamine (Cys) in aqueous solutions under mild conditions. The NPs showed surface charge convertible feature in response to pH change of the solutions. The NPs demonstrated excellent anti nonspecific protein adsorption...
January 29, 2018: Journal of Biomaterials Science. Polymer Edition
Zhu-Le Wang, Shi-Zhou Wu, Zhi-Feng Li, Jin-Hai Guo, Yi Zhang, Jin-Kui Pi, Jun-Gen Hu, Xi-Jing Yang, Fu-Guo Huang, Hui-Qi Xie
Abdominal wall defects are a common medical problem, and inadequate repair methods can lead to serious complications. Abdominal wall reconstruction using autologous tissue, or non-biological, biological, or composite patches is often performed to repair defective areas. In particular, composite patches containing both polymeric and biological materials have gained increasing attention due to their good mechanical properties and biocompatibility. However, it is still unclear whether the quality of repairs using composite patches is superior to that of a biological patch...
January 29, 2018: Journal of Biomaterials Science. Polymer Edition
Farzane Sivandzade, Shohreh Mashayekhan
Cartilage is an avascular tissue with limited self-repair ability. Since the methods for treatment of cartilage defects have not been effective, new therapies based on tissue engineering are considered over the recent years. In this study, human cartilage tissue was decellularized and porous injectable microcarriers (MCs) composed of acellularextracellular matrix (ECM) of cartilage tissue and chitosan(CS), with different ECM weight ratios, were fabricated by electrosprayingtechnique to be used in the treatment of articular cartilage defects...
January 26, 2018: Journal of Biomaterials Science. Polymer Edition
Wenbin Zhu, Chonghui Lao, Shuzhen Luo, Fang Liu, Qiting Huang, Jingwei He, Zhengmei Lin
A synthesized benzothiazole containing mono-methacrylate monomer BTTMA was incorporated into Bis-GMA/TEGDMA dental resin system with a series of mass concentration from 5 wt.% to 30 wt.% as an antibacterial agent. The influence of BTTMA on physicochemical properties of dental resin system, such as double bond conversion (DC), volumetric shrinkage (VS), flexural strength (FS) and modulus (FM), water sorption (WS) and solubility (SL) were investigated. Direct contact testing and agar diffusion testing were used to evaluate the antibacterial activity of BTTMA containing dental resin...
January 17, 2018: Journal of Biomaterials Science. Polymer Edition
Frantisek Straka, David Schornik, Jaroslav Masin, Elena Filova, Tomas Mirejovsky, Zuzana Burdikova, Zdenek Svindrych, Hynek Chlup, Lukas Horny, Matej Daniel, Jiri Machac, Jelena Skibová, Jan Pirk, Lucie Bacakova
The objective of our study was to compare the cellular and extracellular matrix (ECM) structure and the biomechanical properties of human pericardium (HP) with the normal human aortic heart valve (NAV). HP tissues (from 12 patients) and NAV samples (from 5 patients) were harvested during heart surgery. The main cells in HP were pericardial interstitial cells (PICs), which are fibroblast-like cells of mesenchymal origin similar to the valvular interstitial cells (VICs) in NAV tissue. The extracellular matrix (ECM) of HP had a statistically significantly (p ≤ 0...
January 17, 2018: Journal of Biomaterials Science. Polymer Edition
Navid Aeineh, Fahimeh Salehi, Mohammad Akrami, Firouzeh Nemati, Masoumeh Alipour, Milad Ghorbani, Banafsheh Nikfar, Fatemeh Salehian, Nader Riyahi Alam, Seyed Esmaeil Sadat Ebrahimi, Alireza Foroumadi, Mehdi Khoobi, Mohammadreza Rouini, Maryam Dibaei, Ismaeil Haririan, Mohammad Reza Ganjali, Saeed Safaei
Theranostics with the ability to simultaneous monitoring of treatment progress and controlled delivery of therapeutic agents has become as an emerging therapeutic paradigm in cancer therapy. In this study, we have developed a novel surface functionalized iron oxide nanoparticle using polyethyleneimine (PEI) and glutathione (GSH) for targeted curcumin (CUR) delivery and acceptable pH sensitive character. The developed magnetic nanoparticles (MNPs) were physicochemically characterized by FT-IR, XRD, FE-SEM and TEM...
January 11, 2018: Journal of Biomaterials Science. Polymer Edition
Handong Xu, Kai Chen, Dekun Zhang, Xuehui Yang
The torsional friction behavior of the materials (CoCrMo alloy and ultra-high-molecular-weight polyethylene (UHMWPE)) that are used in artificial knee joint replacement (AKJR) were investigated under dynamic loading. The torsional friction torque, wear loss and scars and stress distribution were analyzed and compared. The results show the following: (1) the friction torque declines rapidly at the beginning of the experiments, and meanwhile, the maximum normal load and the torsional angle amplitude show very little effect on the steady value; (2) the wear loss decreases with the increased torsional angle amplitude but increases with the increased maximum normal load; additionally, as the cycle times increase, the wear rate decreases, and the wear is minimal; (3) unloading and secondary loading significantly reduce the friction and wear of the materials, and thus, patients should rest after prolonged exercise to reduce wear; (4) the margins of UHMWPE and CoCrMo are worn, and the wear mechanism is abrasive wear; (5) around the center of the UHMWPE, the surface is peeled off, and the wear mechanism is fatigue wear; and (6) in terms of the compressive stress and shear stress, the calculated results from a finite element model match the experimental results well...
January 10, 2018: Journal of Biomaterials Science. Polymer Edition
Kenji Hagiwara, Kana Kurihara, Masakazu Honma, Junichiro Yamamoto, Fumikazu Shinohara
Nucleic acid medicine is the next-generation therapeutic modality for refractory diseases with its unique mode of action as an alternative to traditional therapies. A nucleic acid delivery system targeted to liver was validated clinically; however, the delivery system of nucleic acids targeting solid tumors following systemic administration is not efficient enough for clinical use. In this study, we first utilized an antisense oligonucleotide (ASO) and polyethylene glycol (PEG) in one-to-one conjugation (PEG-ASO) at the endo-position of the ASO (endo-PEG-ASO)...
January 10, 2018: Journal of Biomaterials Science. Polymer Edition
Chengcheng Zhu, Rui Yang, Xiaobin Hua, Hong Chen, Jumei Xu, Rile Wu, Lian Cen
A highly stretchable hyaluronic acid (HA)/sodium alginate (SA) hydrogel was developed in this study based on an interpenetrating polymer network. HA/SA hydrogels were prepared by mixing two polysaccharides followed by covalent crosslinking via epoxy groups on HA molecules and ionic crosslinking via divalent ions on SA chains sequentially. The effect of HA/SA ratio on the pore size and distribution, swelling ratio, elongation and rheological properties as well as protein loading and release properties of HA/SA hydrogels was explored...
January 10, 2018: Journal of Biomaterials Science. Polymer Edition
Mingxue Chen, Shuang Gao, Pei Wang, Yan Li, Weimin Guo, Yu Zhang, Mingjie Wang, Tongguang Xiao, Zengzeng Zhang, Xueliang Zhang, Xiaoguang Jing, Xu Li, Shuyun Liu, Quanyi Guo, Tingfei Xi
Meniscus is a fibrocartilaginous organ to redistribute stress and enhance the stability of knee joint. Meniscus injury is common and still a formidable challenge to orthopedic surgeons. Surgical techniques and allograft transplantation were primary approaches to meniscus repair, but with intrinsic limitations in clinical practice. Tissue engineering is the most promising method to repair meniscus at present. Electrospinning is a method to fabricate fibers in small scale. With different materials and parameters, electrospinning materials could have different mechanical properties, porosity, and orientation, which could mimic architectural features and mechanical properties of native meniscus...
January 8, 2018: Journal of Biomaterials Science. Polymer Edition
Shengnan Wang, Yi Deng, Lei Yang, Xiuyuan Shi, Weizhong Yang, Zhi-Gang Chen
Implantable polyetheretherketone (PEEK) has great biomedical potential as hard tissue substitute in orthopedic application due to its outstanding mechanical properties and excellent biological stability. However, the poor osseointegration and bacteriostatic ability of implantable polyetheretherketone become the major barrier for its wide clinic application. In this study, a hierarchically micro/nano-topographic polyetheretherketone with specific functional groups (amino and COOH/COOR) has been fabricated using facile sulfonation combined with argon plasma treatment...
January 7, 2018: Journal of Biomaterials Science. Polymer Edition
Devid Maniglio, Walter Bonani, Claudio Migliaresi, Antonella Motta
Silk fibroin has acquired increasing interest for biomedical applications, and namely for the fabrication of scaffolds for tissue engineering, because of its highly positive biological interaction and the possibility to adapt the material to several application requirements by adopting different fabrication methods, in order to make films, sponges, fibers, nets or gels with predictable degradation times. For tissue engineering, in most cases porous scaffolds are required, in some cases possibly in situ forming and therefore fabricated in mild body-compatible conditions...
January 3, 2018: Journal of Biomaterials Science. Polymer Edition
Ayla Şahin, Gozde Eke, Arda Buyuksungur, Nesrin Hasirci, Vasif Hasirci
The aim of this study was to target nano sized (266±25 nm diameter) poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) particles carrying Doxorubicin (DOX), an anticancer agent, to human osteosarcoma cells (Saos-2). A nuclear targeting molecule (Nuclear Localization Signal, NLS), a 17 a.a. peptide, was attached onto the doxorubicin loaded nanoparticles. NLS conjugated nanoparticles surrounded the cell nuclei, but did not penetrate them. Free and nanoparticle-loaded doxorubicin entered the cytoplasm but were evenly distributed within the cytoplasm...
January 3, 2018: Journal of Biomaterials Science. Polymer Edition
Tae Hoon Kim, Jin-Chul Kim
Redox-responsive solid lipid microparticles were prepared by an emulsification photo-polymerization method. Octadecyl acrylate (ODA) and a cross-linker (i.e. allyl disulfide (ADS) and octadiene (ODE)) were dissolved in dichloromethane, it was emulsified in poly(vinyl alcohol) solution, and the resulting O/W emulsion was irradiated with UV light. On the SEM micrographs, the microparticles were sphere-like and they were not markedly different from the oil droplets in size. Using the atomic compositions analyzed by energy dispersive X-ray spectroscopy, the ODA to cross-linker molar ratio of ODA/ADS microparticles and ODA/ODE ones were calculated to be 1:0...
January 2, 2018: Journal of Biomaterials Science. Polymer Edition
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