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Journal of Biomaterials Science. Polymer Edition

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https://www.readbyqxmd.com/read/30157706/determination-of-the-release-of-peg-and-hpmc-from-nelfilcon-a-daily-disposable-contact-lenses-using-a-novel-in-vitro-eye-model
#1
Chau-Minh Phan, Hendrik Walther, Richard W Smith, Donald Riederer, Charis Lau, Kathrine Osborn Lorenz, Lakshman N Subbaraman, Lyndon Jones
The traditional method to measure release of components from CLs is a vial containing a static volume of PBS (phosphate buffered saline). However, this model does not simulate physiologically relevant tear volume and natural tear flow, air exposure, and mechanical rubbing. These factors can significantly impact release kinetics. We have developed an in vitro eye model (OcuFlow) that simulates these parameters. The aim of the study was to measure the release of PEG (polyethylene glycol), and HPMC (hydroxypropyl methylcellulose) from a daily disposable hydrogel contact lens material (nelfilcon A; Dailies AquaComfort PLUS; DACP;) over 24 hrs using the OcuFlow platform...
November 2, 2018: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/30382000/enhanced-glucose-detection-using-dendrimer-encapsulated-gold-nanoparticles-benefiting-from-their-zwitterionic-surface
#2
Longgang Wang, Linlin Zhu, Qingyu Yu, Shengfu Chen, Yanshuai Cui, Haotian Sun, Dawei Gao, Xifa Lan, Qinghua Yang, Haiyan Xiao
The application of ultrasmall gold nanoparticles as enzyme mimics has been drawing great attention. Herein, we developed zwitterionic dendrimer encapsulated gold nanoparticles (Au-G5MC NPs) for highly sensitive and simple colorimetric detection of glucose. Au-G5MC NPs showed peroxidase-like property, which could efficiently catalyze oxidation of 3,3',5,5'-tetramethylbenzidine (TMB) in the presence of H2 O2 , producing a blue color product (oxTMB). This peroxidase-like reaction follows a typical Michaelis-Menten kinetics...
November 1, 2018: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/30376409/pharmacokinetic-and-anti-colon-cancer-properties-of-curcumin-containing-chitosan-pectinate-composite-nanoparticles
#3
Enas Alkhader, Clive J Roberts, Rozita Rosli, Kah Hay Yuen, Eng Kwong Seow, You Zhuan Lee, Nashiru Billa
Curcumin, the active ingredient of the rhizome curcuma longa has been extensively studied as an anticancer agent for various types of tumours. However, its efficacy as an anticancer agent is restricted due to poor absorption from the gastrointestinal tract, rapid metabolism and degradation in acidic medium. In the present study, we encapsulated curcumin in chitosan-pectinate nanoparticulate system (CUR-CS-PEC-NPs) for deployment of curcumin to the colon, whereby curcumin is protected against degradative effects in the upper digestive tract, and hence, maintaining its anticancer properties until colon arrival...
October 30, 2018: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/30220215/a-combined-compression-molding-heating-and-leaching-process-for-fabrication-of-micro-porous-poly-%C3%AE%C2%B5-caprolactone-scaffolds
#4
Nicole D Sempertegui, Akshay A Narkhede, Vinoy Thomas, Shreyas S Rao
Biomaterial scaffolds have been increasingly used for tissue engineering applications as well as three dimensional (3D) cell culture models. Herein, we report a simple procedure combining compression molding, heating, and leaching methods for the fabrication of 3D micro-porous poly(ε-caprolactone) (PCL) biomaterial scaffolds. In this procedure, PCL micro particles are mixed with NaCl of defined sizes and compression molded, followed by heating and subsequent leaching of NaCl particles. This technique eliminates the gas foaming method, which is commonly used in the fabrication of PCL scaffolds...
October 30, 2018: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/30209974/generation-of-bioactive-nano-composite-scaffold-of-nanobioglass-silk-fibroin-carboxymethyl-cellulose-for-bone-tissue-engineering
#5
B N Singh, K Pramanik
The development of bone tissue construct through tissue engineering approach offers a great promise in meeting the increasing demand for repair and regeneration of damaged and/or diseased bone tissue. For the generation of bone tissue engineered construct, polymer-ceramic composite matrices with nanostructure architecture and mesenchymal stem cells (hMSCs) of human origin are of prime requirement. Keeping these in view, in the present work a novel electrospun nanofibrous silk fibroin (SF)/carboxymethyl cellulose (CMC)/nano-bioglass (nBG) composite scaffold that mimics native bone extracellular matrix with appropriate composition was designed and fabricated by free liquid surface electrospinning technique...
October 29, 2018: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/29920151/paclitaxel-and-etoposide-loaded-poly-lactic-co-glycolic-acid-microspheres-fabricated-by-coaxial-electrospraying-for-dual-drug-delivery
#6
Mei Zhang, Yajun Tang, Zhenhua Zhu, He Zhao, Jihang Yao, Dahui Sun
In this study, we fabricated paclitaxel (PTX) and etoposide (ETP) loaded Poly (lactic-co-glycolic acid) (PLGA) microspheres with core-shell structures and particle sizes ranging from 1 to 4 µm by coaxial electrospraying. The microspheres were analyzed by scanning electron microscopy (SEM), transmission electron microscopy (TEM). The drug loading rate and entrapment efficiency of the microspheres were detected by high performance liquid chromatograph (HPLC). Moreover, the drug release profiles and degradation of drug-loaded PLGA microspheres in vitro were investigated, respectively...
October 29, 2018: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/30324858/characterization-of-surface-modified-glycerol-silk-fibroin-film-for-application-to-corneal-endothelial-cell-regeneration
#7
Jeong Eun Song, Bo Ra Sim, Yoo Shin Jeon, Han Sol Kim, Eun Yeong Shin, Cristiano Carlomagno, Gilson Khang
Corneal endothelial cells (CEnCs) play a fundamental role in maintaining the transparency of the cornea. CEnCs lose their full proliferating capacity when tissue damages occur. The loss in proliferation rate is associated with corneal edema and decrease in visual acuity, leading in severe cases, to blindness. In these situations, a corneal transplant is usually needed to restore the original tissue functions. Tissue engineering is an efficient alternative for the production of implantable films, which can regenerate the tissue functions regulating at the same time the immune-response...
October 16, 2018: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/30141735/a-strategy-for-controlling-degradation-in-vitro-of-carbon-fiber-reinforced-polylactic-acid-composites-by-combining-fiber-modification-and-pulsed-electromagnetic-fields
#8
Di Zhang, Jingang Qi, Sifan Qiao, Liang Liu, Bing Wang, Zuofu Zhao
Carbon fiber-reinforced polylactic acid (C/PLA) composites are a human bone-fixation material, but control of the material's degradation remains a major factor hindering its widespread use. In this study, a combined method for controlling the degradation performance in vitro of C/PLA composites was designed. In this strategy, carbon fibers for C/PLA composite reinforcement were prepared in both modified and unmodified forms. A pulsed electromagnetic field (PEF) was then selectively applied during the subsequent degradation process...
October 15, 2018: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/30311855/in-situ-photocrosslinked-hyaluronic-acid-and-poly-%C3%AE-glutamic-acid-hydrogels-as-injectable-drug-carriers-for-load-bearing-tissue-application
#9
Xuebin Ma, Shuai Liu, Hejun Tang, Rong Yang, Bo Chi, Zhiwen Ye
Due to the syringeability of precursor solution and convenience of open surgical treatment, injectable hydrogels have gained growing attention in drug delivery application. For load-bearing tissue, the excellent mechanical property is an important requirement for delivery vehicles to resist external stress and loads. Herein, we prepared mechanically robust injectable hydrogels (HA/γ-PGA hydrogels for short) using methacrylate-functionalized hyaluronic acid and poly (γ-glutamic acid) via photopolymerization...
October 12, 2018: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/30307376/simvastatin-delivery-on-peek-for-bioactivity-and-osteogenesis-enhancements
#10
Li-Jun Deng, Yan-Lin Wu, Xian-Hua He, Ke-Nan Xie, Lu Xie, Yi Deng
The strategy of a functional biomimetic system built to obtain the positive cellular response remains a field of topical interest. In this study, a hydrogel covered simvastatin-loaded polyetheretherketone (PEEK) bio-composites was constructed with the purpose of bone tissue regeneration therapy. Briefly, a three-dimensional (3D) porous structure was fabricated on PEEK surface; then the substrate was functionalized with the poly(L-lactic acid)/simvastatin porous film and hyaluronic acid hydrogel subsequently...
October 11, 2018: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/30303463/synthesis-and-characterization-of-albumin-imprinted-polymeric-hydrogel-membranes-for-proteomic-studies
#11
Esra Feyzioğlu, Emir Özçalışkan, Hayriye Karakaş, Murat Uygun, Deniz Aktaş Uygun, Sinan Akgöl, Adil Denizli
In this presented study, a novel molecularly imprinted polymeric hydrogel membranes (PHMs) were developed to use for the albumin depletion studies. For this, albumin imprinted poly(2-hydroxyethyl methacrylate-N-methacryloyl-(L)-phenylalanine methyl ester) polymeric hydrogel membranes [p(HEMA-MAP) PHMs] were synthesized by the photopolymerization technique, and then characterized by SEM, EDX, FT-IR and swelling studies. Synthesized PHMs had spherical structure and the MAP monomer incorporation onto the PHMs was determined by EDX analysis by using nitrogen stoichiometry...
October 10, 2018: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/30295148/preparation-of-gelatin-genipin-nanofibrous-membrane-for-tympanic-member-repair
#12
Longfei Li, Weizheng Zhang, Mengjia Huang, Jie Li, Jia Chen, Mi Zhou, Jianguo He
The wound healing for tympanic membrane (TM) perforations is one of the most common clinical treatment in otomicrosurgery. Recently, tissue-engineered composites and grafts, also new designs of biomaterials are applied to the management of TM perforation. In this work, a series of gelatin/genipin nanofibrous films were prepared as a patch for repairing TM perforation. Gelatin, a type of biomaterial with excellent electrospinning performance, has been used for preparing the nanofibers. The genipin, as a crosslinking agent, has been blended into the gelatin nanofibers...
October 8, 2018: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/30173602/effect-of-inflammation-on-endothelial-cells-induced-by-poly-l-lactic-acid-degradation-in-vitro-and-in-vivo
#13
Dongping Chen, Zhaobing Su, Linsheng Weng, Longbin Cao, Can Chen, Sufen Zeng, Suzhen Zhang, Tim Wu, Qiang Hu, Jianmin Xiao
As a promising candidate, biodegradable Poly-L-lactic Acid (PLLA) has been extensively used in coronary artery stents. In our previous reports, PLLA stents implanted in porcine coronary arteries showed safety without stent thrombosis. However, inflammatory responses were observed, which needed further study. In this study, human aortic endothelial cells (HAEC) were treated with different volume percentages of extract of pre-degraded PLLA (extract of PLLA) in vitro, and the cell growth curve and morphological changes were examined...
October 8, 2018: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/30156968/the-response-of-bone-cells-to-titanium-surfaces-modified-by-simvastatin-loaded-multilayered-films
#14
Min Lai, Xufeng Yan, Ziyang Jin
The aim of this study was to enhance cytocompatibility of titanium substrates by loading a multilayer film of chitosan (Chi), gelatin (Gel) and simvastatin (SV). This was fabricated using a spin-assisted layer-by-layer (LBL) technique. The surface properties of the different substrates were characterized by field emission scanning electron microscopy (FE-SEM), atomic force microscope (AFM), X-ray photoelectron spectroscopy (XPS) and contact angle measurement, respectively. Simvastatin release in vitro was measured by ultraviolet-visible spectrophotometer...
October 7, 2018: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/30132379/fabrication-of-three-dimensional-nanofibrous-gelatin-scaffolds-using-one-step-crosslink-technique
#15
Fangjun Teng, Huifen Ding, Yiqing Huang, Jiawei Wang
Electrospun nanofibers have been considered to be an ideal scaffold for tissue engineering, because of the extracellular-matrix-like structure and the well-controlled fabrication. Here, a new method was used to fabricate electrospun three-dimensional macroporous nanofibrous gelatin scaffolds in ethanol bath by one-step crosslink with glutaraldehyde. The mean diameter of the one-step crosslinked fibers was significantly smaller than that of the traditional two-step crosslinked fibers (p < 0.05), and scaffolds prepared by one-step crosslink were fluffy and porous...
October 7, 2018: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/30285546/molecular-self-assembly-of-copolymer-from-renewable-phenols-new-class-of-antimicrobial-ointment-base
#16
Denial Mahata, Santi M Mandal
Ointments are highly viscous forms intended for external applications either medicated or non-medicated means. Formulation of ointment depends upon the base ingredients to measure the viscosity difference. Several limitations of ointment bases has been encountered timely as agglomeration, oil phase ingredients can form lumps, poor dispersion, poor drug delivery efficiency, make stained, immiscible, and difficult to wash off. Therefore, it is necessary to make a new type of ointment bases that can overcome those limitations...
October 4, 2018: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/30285542/amphiphilic-block-copolymer-nps-obtained-by-coupling-ricinoleic-acid-sebacic-acids-and-mpeg-synthesis-characterization-and-controlled-release-of-paclitaxel
#17
Shiya Zhou, Wei Sun, Yinglei Zhai
Currently, nanoparticles (NPs) made of amphiphilic block copolymer are still an essential part of drug delivery system. Here, we report a novel amphiphilic block copolymer and paclitaxel (PTX)-loaded copolymer NPs for the controlled delivery of PTX. The block copolymer was synthesized via melt polycondensation method of methoxy poly(ethylene glycol) (mPEG), sebacic acid (SA) and ricinoleic acid (RA). A series of characterization approaches such as Fourier Transform Infrared Spectroscopy (FTIR), 1 Hydrogen-Nuclear Magnetic Resonance (1 H-NMR), Differential Scanning Calorimetry (DSC), X-Ray Diffraction (XRD) and Gel Permeation Chromatography (GPC) applied have shown that the amphiphilic block copolymer was prepared as designed...
October 4, 2018: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/30280964/in-situ-synthesis-of-bacterial-cellulose-copper-nanoparticles-composite-membranes-with-long-term-antibacterial-property
#18
Wei He, Xiangqi Huang, Yudong Zheng, Yi Sun, Yajie Xie, Yansen Wang, Lina Yue
Bacterial cellulose (BC), with unique structure and properties, has attracted much attention in the biomedical field, especially in using as wound dressing. However, pure BC lacks the antimicrobial activity, which limits its application in wound healing. To solve this problem, copper nanoparticles (Cu NPs) loaded BC membranes were fabricated by using in situ chemical reduction method. The morphology and chemical composition of the composite membranes were characterized by scanning electron microscopy (SEM), X-ray diffraction (XRD), Fourier Transform Infrared (FTIR) and thermogravimetric analysis (TGA)...
October 3, 2018: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/30183550/one-step-fabricated-keratin-nanoparticles-as-ph-and-redox-responsive-drug-nanocarriers
#19
Xuelian Zhi, Pengcheng Liu, Yanmei Li, Pengfei Li, Jiang Yuan, Jiantao Lin
Keratin is a promising material for building drug carriers due to their biocompatibility, reduction sensitivity, and biodegradability. Herein, we aim to develop acid and glutathione (GSH) dual-responsive keratin-based drug carriers with a one-step strategy. Keratin/DOX complexes were first prepared by means of a simple mixing approach, followed by desolvation and crosslinking to prepare keratin-based drug loaded nanoparticles (KDNPs). The as-prepared KDNPs showed negative-charged surface and globular morphology with the diameter of ca...
October 3, 2018: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/30156966/the-improvement-of-calvarial-bone-healing-by-durable-nanogel-crosslinked-materials
#20
Pornkawee Charoenlarp, Arun Kumar Rajendran, Rie Fujihara, Taisei Kojima, Ken-Ichi Nakahama, Yoshihiro Sasaki, Kazunari Akiyoshi, Masaki Takechi, Sachiko Iseki
Different approaches have been developed to improve the scaffold properties that provide structural support and biological interaction to achieve the desired environment for tissue regeneration. We previously reported that addition of human fibroblast growth factor 18 (hFGF18) to acryloyl group-modified cholesterol-bearing pullulan (CHPOA) nanogel-crosslinked (NanoClik) hydrogels that contain human bone morphogenetic protein 2 (hBMP2) stabilized bone healing in mouse calvarial defect model. In this study, we evaluated the use of disc-shaped dried nanogel-crosslinked gel as carriers of growth factors in order to seek possible clinical application in future...
October 3, 2018: Journal of Biomaterials Science. Polymer Edition
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