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Journal of Biomaterials Science. Polymer Edition

Youming Deng, Jianan Ren, Guopu Chen, Gefei Wang, Guosheng Gu, Jieshou Li
: Background:This study was aimed to evaluate the effect of tannin acid- polyethylene glycol (TP) adhesive on the wound healing process of primary colonic anastomosis in the open abdomen (OA). MATERIALS AND METHODS: Adhesion strength test, degradation and hemostatic ability of TP were investigated. In a rat model, after standard colonic anastomoses, rats were divided into three groups: OA group; OA + FG (fibrin glue) group; OA + TP group. Five days after surgery, body weight, anastomotic bursting pressure (ABP), and histology of anastomotic tissue were evaluated...
December 2, 2016: Journal of Biomaterials Science. Polymer Edition
Xinxin Chen, Rui Zhao, Xiang Wang, Xiang Li, Fei Peng, Zhenghua Jin, Xinxin Gao, Jiaao Yu, Ce Wang
Wound care treatment is a serious issue faced by the medical staffs due to its variety and complexity. Wound dressings are typically used to manage the various types of wounds. In this study, polyurethane (PU) fibers containing mupirocin (Mu), a commonly used antibiotic in wound care, were fabricated via electrospinning technique. The aim of this study was to develop biomedical electrospun fiber scaffolds for preventing wound infections with good compatibility and to demonstrate their applications as anti-infective burn wound dressings...
December 1, 2016: Journal of Biomaterials Science. Polymer Edition
Laurent Leclercq, Michel Vert
A previous investigation suggested that a surface bearing a rinsing-resistant depot (nanocoating) of albumin is more protein-repulsive than the same surface physically pegylated by a poly(D,L-lactic acid)-poly(ethylene oxide) diblock copolymer. To complement the study, Optical Waveguide Lightmode Spectroscopy was used to compare the mass and the thickness of protein depots from different systems, namely albumin alone at different concentrations, a mixture of albumin + fibrinogen + γ-globulin at their physiological concentrations, and sheep serum...
November 30, 2016: Journal of Biomaterials Science. Polymer Edition
D P Biswas, P A Tran, C Tallon, A J O'Connor
In this paper, a novel foaming methodology consisting of turbulent mixing and thermally induced phase separation (TIPS) was used to generate scaffolds for tissue engineering. Air bubbles were mechanically introduced into a chitosan solution which forms the continuous polymer/liquid phase in the foam created. The air bubbles entrained in the foam act as a template for the macroporous architecture of the final scaffolds. Wet foams were crosslinked via glutaraldehyde and frozen at -20 °C to induce TIPS in order to limit film drainage, bubble coalescence and Ostwald ripening...
November 30, 2016: Journal of Biomaterials Science. Polymer Edition
Sijin Huang, Jialei Wang, Qing Shang
A monomer of sucrose acrylate (AC-sucrose) was synthesized by conjugating starting compound sucrose with methyl acrylate (MA). The obtained AC-sucrose was characterized by mass spectrometry (MS) and Fourier transform infrared (FTIR) spectroscopy. AC-sucrose was selected as a monomer to fabricate a novel pH sensitive hydrogel via free radical polymerization. The inner morphology of the final hydrogel was observed with an S-4800 scanning electron microscope (SEM). The swelling and de-swelling behaviors of the hydrogel chips were also studied...
November 23, 2016: Journal of Biomaterials Science. Polymer Edition
Hao Yu, Wei Li, Xing Liu, Chen Li, Hong Ni, Xiong Wang, Céline Huselstein, Yun Chen
A series of chitosan-modified zein composite films were fabricated from zein and chitosan by a process involving blending, solution casting and evaporation. Effects of chitosan content on the structure and physical properties of the composite films were investigated by Fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), scanning electron microscopy (SEM), tensile testing, water absorption measurement and water contact angle measurement. The results showed that the zein/chitosan composite films were fabricated successfully due to the formation of hydrogen bonds between zein and chitosan, and the thermal stability, water absorption, hydrophilicity, tensile strength, flexibility of the composite films increased with an increase in chitosan content from 0 to 50%...
November 23, 2016: Journal of Biomaterials Science. Polymer Edition
Takuya Koriyama, Yosuke Takayama, Chiho Hisatsune, Taka-Aki Asoh, Akihiko Kikuchi
To confirm the modification of a dense thermoresponsive polymer brush on a silica surface by surface-initiated (SI) atom transfer radical polymerization (ATRP), poly(N-isopropylacrylamide) (PNIPAAm) was polymerized from a free ATRP initiator and an ATRP initiator immobilized silica particle (SiP) via ATRP under various initiator concentrations. The obtained PNIPAAm exhibited a well-controlled molecular weight and modification of the concentrated PNIPAAm brush on the SiP surface was confirmed. Based on the optimal ATRP conditions, the PNIPAAm- and poly(NIPAAm-co-butyl methacrylate [BMA]) (PIB)-grafted capillary lumen were prepared by SI-ATRP and used as capillary columns for micro high-performance liquid chromatography for the modulation of biomolecular interactions...
November 21, 2016: Journal of Biomaterials Science. Polymer Edition
Vijaykumar V Alange, Ravindra P Birajdar, Raghavendra V Kulkarni
Unique pH-sensitive spray dried microspheres were formulated employing hydrolyzed polyacrylamide-g-carboxymethylcellulose sodium (PAAm-g-NaCMC) co-polymer for colon targeted delivery of an anticancer drug, capecitabine. Synthesis of PAAm-g-NaCMC was carried out through free radical polymerization, which was supported with an inert atmosphere and then the alkaline hydrolysis was performed and subjected for characterization including FTIR spectroscopic analysis, (1)H NMR spectroscopic analysis, elemental analysis, viscosity measurement, neutralization equivalent and thermo-gravimetric investigation...
November 21, 2016: Journal of Biomaterials Science. Polymer Edition
Jingjing Yao, Decheng Zeng, Yangxin Zhang, Dongdong Sun, Endong Yang, Haiping Liu, Feng Guo, Weiyun Wang
The effect of ethanol or acetone, as oil phase solvents, upon the form of paeonol-loaded poly(butyl-2-cyanoacrylate) encapsulated nanocapsules (Pae@PNCs) by interfacial spontaneously condensation were investigated. Pae@PNCs characterizations including morphology, radius distribution, polydispersity index (PDI), particle size, zeta potential, entrapment efficiency (EE%), drug loading (DL%) and in-vitro paeonol release kinetics were evaluated. Results show that 100% acetone have a significant effect on forming nanocapsules, which showed the smaller size (168...
November 16, 2016: Journal of Biomaterials Science. Polymer Edition
Shengnan Yin, Yiran Xia, Qi Jia, Zhao-Sheng Hou, Na Zhang
This study describes the preparation and properties of a novel aliphatic cost-effective segmented polyurethanes (SPUs) based on poly(ether ester) (poly-(ε-caprolactone-co-L-lactide)-poly(ethylene glycol)-poly-(ε-caprolactone-co-L- lactide), PECLA) and uniform-size diurethane diisocyanates (HDI-BDO-HDI). PECLA was synthesized via bulk ring-opening polymerization with poly(ethylene glycol) (PEG) as an initiator and ε-caprolactone, L-lactide as monomers. By chain extension of PECLA diol with HDI-BDO-HDI, three SPUs with different hydrophilic segments content and hard segments content were obtained...
October 23, 2016: Journal of Biomaterials Science. Polymer Edition
Jie Tao, Jiumeng Zhang, Yu Hu, Yuan Yang, Zhiyuan Gou, Ting Du, Jian Mao, Maling Gou
Conventional surgical methods can not completely remove the tumor cells, and an inevitable recurrence always results in death. In this study, we prepared a conformal hydrogel nanocomposite with potential to inhibit the recurrence of glioma. Based on the MRI of a patient's brain tumor cavity (BTC), we 3D-printed a mould for preparing the customized implants that could match the resection cavity. The obtained macroporous hydrogel, containing paclitaxel (PTX) nanoparticles, could sustained release PTX. From the confocal microscopy image, we could detect that the hydrogel nanocomposite combined with nanoparticles uniformly...
October 21, 2016: Journal of Biomaterials Science. Polymer Edition
Javad Hashemi, Sameereh Hashemi-Najafabadi, Ebrahim Vasheghani-Farahani
In this study, a method is proposed to reduce immunological response of immune system against Langerhans islets by PEGylation of islets combined with adjuvant therapy. For this purpose, the best composition for a mixture of succinimidyl valeric acid activated mPEG (mPEG-SVA) with different molecular weights (MWs) and for a mixture of succinimidyl carbonate activated mPEG (mPEG-SC) with different MWs was determined separately. Then, the effect of pentoxifylline (PTX) as an adjuvant drug on immunological response against PEGylated islets at best mPEG composition was studied...
October 13, 2016: Journal of Biomaterials Science. Polymer Edition
Yomaira L Uscátegui, Fabián R Arévalo, Luis E Díaz, Martha I Cobo, Manuel F Valero
The objective of this study was to assess the effects of type of polyol and concentration of polycaprolactone (PCL) in polyurethanes (PUs) on microbial degradability, cytotoxicity, biological properties and antibacterial activity to establish whether these materials may have biomedical applications. Chemically modified and unmodified castor oil, PCL and isophorone diisocyanate in a 1:1 ratio of NCO/OH were used. PUs were characterized by stress/strain fracture tests and hardness (ASTM D 676-59). Hydrophilic character was determined by contact angle trials and morphology was evaluated by scanning electron microscopy...
October 11, 2016: Journal of Biomaterials Science. Polymer Edition
Aysu Arslan, Soner Çakmak, Alper Cengiz, Menemşe Gümüşderelioğlu
The aliphatic-aromatic copolyester, poly(butylene adipate-co-terephthalate) (PBAT) combines good mechanical and thermal properties with biodegradation ability. However, until now, researches in its potential medical use remain limited. Only in a few studies blends of PBAT with routinely used biocompatible polymers had been prepared and investigated regarding tissue engineering applications. Therefore, in this study, we decided to determine processability of neat PBAT as a scaffold material for bone tissue by using different fabrication methods i...
October 10, 2016: Journal of Biomaterials Science. Polymer Edition
Gang Zhou, Lei Wang, Jianchao Li, Jun Tai, Haisheng Su, Jing Zhang, Yuan Xi, Yubo Fan
The accumulation of uremic toxins in blood might induce chronic renal failure (CRF). The incidence of CRF was as high as 10%. The traditional therapy for CRF was hemodialysis, which was more effective to remove small molecules, such as urea and creatinine. However, this detoxification method ignored the tissue functional adaption due to the retention of macromolecule uremic toxins. To solve this problem, this paper developed a new kind of chitosan/carboxyl graphite oxide (CS/GO-COOH) scaffold via a double-lyophilization method...
October 10, 2016: Journal of Biomaterials Science. Polymer Edition
Yanxia Wang, Fan Huang, Yingjuan Sun, Ming Gao, Zhihua Chai
Shell cross-linked nanoparticles were fabricated by the complexation of poly(3-methacrylamido phenylboronic acid) (PMAPBA) and thiolated chitosan (chitosan-SH) via boronic acid-related reactions. The formation of PMAPBA/chitosan-SH nanoparticles was confirmed by transmission electron microscopy, dynamic light scattering, and UV spectroscopy. The nanoparticles had a narrow size distribution with a relatively high positive charge density, and the size and zeta potential of the nanoparticles correlated with the chitosan-SH concentration...
October 8, 2016: Journal of Biomaterials Science. Polymer Edition
Guiting Liu, Hongxun Zhou, Hong Wu, Rong Chen, Shaoyun Guo
Homogeneous alginate hydrogels were facilely fabricated through solution extrusion process. CaCO3 and D-glucono-δ-lactone (GDL) were used as the gelation agents. The slow gelation of alginate was realized by the in-situ release of Ca(2+) from CaCO3 particles induced by hydrolysis of GDL to reduce pH. Slight gelation during the extrusion caused the enhanced strength of the alginate solutions, leading to the extrudability of the blends. This method enables to produce alginate hydrogels in a single step via extrusion, which is economically advantageous to conventional lab-scale preparation for mass production...
October 7, 2016: Journal of Biomaterials Science. Polymer Edition
Xueqiong Zhang, Chunfu Li, Hua Zheng, Haoyuan Song, Lianghong Li, Fuliang Xiong, Jin Yang, Tong Qiu
Novel glutathione (GSH)-dependent micelles based on carboxymethyl chitosan (CMCS) were developed for triggered intracellular release of doxorubicin (DOX). DOX-33'-Dithiobis (N-hydroxysuccinimidyl propionate)-CMCS (DOX-DSP-CMCS) prodrugs were synthesized. DOX was attached to the amino group on CMCS via disulfide bonds and drug-loaded micelles were formed by self-assembly. The micelles formed core-shell structure with CMCS and DOX as the shell and core, respectively, in aqueous media. The structure of the prodrugs was confirmed by IR and proton nuclear magnetic resonance ((1)H NMR) spectroscopy...
October 5, 2016: Journal of Biomaterials Science. Polymer Edition
Benyan Liu, Zhangyuan Luo, Wenzan Zhang, Quan Tu, Xun Jin
In this study, the concept of polymer electrodes integrated with a wireless electrocardiogram (ECG) system was described. Polymer electrodes for long-term ECG measurements were fabricated by loading high content of carbon nanotubes (CNTs) in polydimethylsiloxane. Silver nanoparticles (Ag NPs) were added to increase the flexibility of the polymer and the conductivity of the electrode. An ECG electrode patch was fabricated by integrating the electrodes with an adhesive polydimethylsiloxane (aPDMS) layer. Holes in the electrode filled with aPDMS can enable robust contact between the electrode and skin, reducing motion artifacts...
October 5, 2016: Journal of Biomaterials Science. Polymer Edition
Zhenbao Liu, Chunyan Wang, Yanfei Liu, Dongming Peng
Cefepime (CFP) is a frequently used antibiotic for prevention of post-surgery infection. Systemic delivery of CFP in a bulk dose usually shows effective therapeutic effects, while cytotoxicity can also be generated. To avoid the drawback of systemic delivery of antibiotic, local and controlled administration of drug is being employed to prolong therapeutic effects and reduce cytotoxicity by sustaining drug release and minimizing drug exposure. In this work, CFP loaded polymer O-carboxymethyl chitosan (OCMC) microspheres (CFP-OCMC-MPs) were fabricated and their antimicrobial activity against Staphylococcus aureus was evaluated...
October 4, 2016: Journal of Biomaterials Science. Polymer Edition
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