Read by QxMD icon Read

Journal of Biomaterials Science. Polymer Edition

Cemile Kilic Bektas, Ilgin Kimiz, Aylin Sendemir Urkmez, Vasif Hasirci, Nesrin Hasirci
Treatment of chronic skin wound such as diabetic ulcers, burns, pressure wounds are challenging problems in the medical area. The aim of this study was to design a bilayer skin equivalent mimicking the natural one to be used as a tissue engineered skin graft for use in the treatments of problematic wounds, and also as a model to be used in research related to skin, such as determination of the efficacy of transdermal bioactive agents on skin cells and treatment of acute skin damages that require immediate response...
July 12, 2018: Journal of Biomaterials Science. Polymer Edition
Roopa Reddy, Narendra Reddy
Advancement in medical technologies, emergence of new diseases and need for quick and effective treatments have increased the requirement for unique and distinct materials. A plethora of materials in various forms, shapes and sizes have been developed from polymers, metals and ceramics and extensively explored for both in vitro and in vivo applications. When used inside the body, biomaterials include metals, polymers and ceramics typically as implants, scaffolds, drug or gene carriers and also as protective agents...
July 12, 2018: Journal of Biomaterials Science. Polymer Edition
M F Abdullah, Ahmad Azfaralariff, Azwan Mat Lazim
This research aims to compare the ability of smart hydrogel in removing the methylene blue prepared by using two different radiation methods. The extracted pectin from the dragon fruit peel (Hylocereus polyrhizus) was used with acrylic acid (AA) to produce a polymerized hydrogel through gamma and microwave radiation. The optimum hydrogel swelling capacity was obtained by varying the dose of radiation, pectin to AA ratio and pH used. From the array of samples, the ideal hydrogel was obtained at pH 8 with a ratio of 2:3 (pectin: AA) using 10 kGy and 400 W radiated gamma and microwave respectively...
July 10, 2018: Journal of Biomaterials Science. Polymer Edition
Sarumathi G, Siti Solehah Z, Siti Fatmah A, Mohamad Nabil Ia, Rajasegaran M, Hanis Nazihah Hasmad, Mohd Reusmaazran Bin Yusof, Salina H, Haslinda Aa, Y Lokanathan
Amniotic membrane has the potential to be used as scaffold in various tissue engineering applications. However, increasing its biostability at the same time maintaining its biocompatibility is important to enhance its usage as a scaffold. This studied characteristics genipin-crosslinked amniotic membrane as a bioscaffold. Redundant human amniotic membranes (HAM) divided into native (nAM), decellularized (dAM) and genipin-crosslinked (clAM) groups. The dAM and clAM group were decellularized using thermolysin (TL) and sodium hydroxide (NaOH) solution...
July 8, 2018: Journal of Biomaterials Science. Polymer Edition
Ke Ma, Hong Xia, Qing-Qing Ni
Currently available synthetic grafts demonstrate moderate success at the macrovascular level, but there are still challenges at small vascular scale (inner diameter of less than 6 mm). In this paper, silk fibroin (SF)/polyurethane (PU)/SF three-layer drug carrier nanofibrous tubes were developed for blood vessel repair with several advantages over existing designs. Our design consisted of a bionic three-layer microtube that was synthesized from the drug carrier SF and oligomeric proanthocyanidin nanofibers as the inner layer, PU nanofibers as the middle layer, and SF nanofibers as the outer layer...
July 2, 2018: Journal of Biomaterials Science. Polymer Edition
Anil Thankam, Qudes Al-Anbaky, Zeiyad Al-Karakooly, Ambar B Rangu Magar, Bijay P Chhetri, Nawab Ali, Anindya Ghosh
Biocompatible bone implants composed of natural materials are highly desirable in orthopedic reconstruction procedures. In this study, novel and ecofriendly bionanocomposite hydrogels were synthesized using a blend of hydroxypropylguar (HPG), poly vinyl alcohol (PVA), and nano-hydroxyapatite (n-HA) under freeze-thaw and mild reaction conditions. The hydrogel materials were characterized using various techniques. TGA studies indicate that both composites, HPG/PVA and HPG/PVA/n-HA, have higher thermal stability compared to HPG alone whereas HPG/PVA/n-HA shows higher stability compared to PVA alone...
July 2, 2018: Journal of Biomaterials Science. Polymer Edition
Wenqian Xiao, Yunfei Tan, Jiale Li, ChengFu Gu, Hang Li, Bo Li, Xiaoling Liao
Despite considerable research effort, the natural hydrogels presently available for tissue engineering suffer from several major drawbacks, one of the significant issue is their poor mechanical strength which are unable to satisfy some mechanical requirements for successful outcomes. Herein, to mimic the composition and structure of the natural extracellular matrix, the micron-sized silk fibers obtained by alkaline hydrolysis were used as a reinforcement phase in a GelMA hydrogel, resulting in a material with significantly greater stiffness than pure GelMA hydrogel alone...
June 26, 2018: Journal of Biomaterials Science. Polymer Edition
Khadijah Zai, Narumi Ishihara, Hiroyuki Oguchi, Masato Hirota, Akihiro Kishimura, Takeshi Mori, Koji Hase, Yoshiki Katayama
Immunomodulatory function of all-trans retinoic acid (ATRA) has been gathering much attention for the therapy of autoimmune diseases. ATRA is a chemically unstable molecule which requires proper formulation for targeted delivery. Here we examined nanostructured lipid carrier (NLC) for the formulation of ATRA. NLC is a representative nanoparticle formulation especially suited for oral delivery. We established the preparation procedures of ATRA-containing NLC (NLC-RA) which minimizes the degradation of ATRA during the preparation process...
June 26, 2018: Journal of Biomaterials Science. Polymer Edition
Jianlin Luo, Yonglu Meng, Lingling Zheng, Kangkang Xu, Can Li
Chinese giant salamander (CGS) has high medicinal value and long history of clinical use in ancient China. In this study, CGS skin (CGSS) collagen was extracted and purified to prepare collagen sponge by freeze-drying. TEMPO oxidized microfibrillated cellulose (TEMPO-MFC) and genipin were adopted to improve the mechanical properties of collagen sponge. The hygroscopicity, porosity, mechanical properties, hemostatic performance, morphology, and biodegradability of the resultant sponges were investigated in detail...
June 19, 2018: Journal of Biomaterials Science. Polymer Edition
Mei Zhang, Yajun Tang, Zhenhua Zhu, He Zhao, Jihang Yao, Dahui Sun
In this study, we fabricated paclitaxel (PTX) and etoposide (ETP) loaded Poly (lactic-co-glycolic acid) (PLGA) microspheres with core-shell structures and particle sizes ranging from 1 to 4 µm by coaxial electrospraying. The microspheres were analyzed by scanning electron microscopy (SEM), transmission electron microscopy (TEM). The drug loading rate and entrapment efficiency of the microspheres were detected by high performance liquid chromatograph (HPLC). Moreover, the drug release profiles and degradation of drug-loaded PLGA microspheres in vitro were investigated, respectively...
June 19, 2018: Journal of Biomaterials Science. Polymer Edition
Junxia Yu, Huantong Su, Shuda Wei, Fangping Chen, Changsheng Liu
Blood coagulates are closely related to calcium ions (coagulation factor IV), and calcium-doped biomaterials have been reported to be effective in hemostasis. However, the effects exerted by calcium on hemostatic agents have not been previously investigated. The aims of this work were to develop calcium-modified oxidized microporous starch (CaOMS) with controllable calcium contents and to explore the relationship between calcium content and hemostatic effects. The results showed that low calcium content promoted coagulation, while high calcium content inhibited coagulation...
June 14, 2018: Journal of Biomaterials Science. Polymer Edition
Junde Guo, Tangjie Mei, Yue Li, Mahshid Hafezi, Hailin Lu, Jianhui Li, Guangneng Dong
This work presents a method for one-pot synthesis of N-doped nanometer-size carbon dots, which can be assembled with thermosensitive poly(ε-caprolactone)-poly(ethylene glycol)-poly(ε-caprolactone) (PCL-PEG-PCL, PCEC) hydrogel to achieve slow-release lubricity. The typical property of this green production was studied by fourier transform infrared (FT-IR), X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS) and transmission electron microscope (TEM). The photoluminescence of composite PCEC/CDs hydrogel and its released solutions were characterized by ultraviolet spectrum, and the rheological properties were tested by rotary rheometer...
June 12, 2018: Journal of Biomaterials Science. Polymer Edition
Caochuan Feng, Xiaoxiong Han, Lili Chi, Jing Sun, Feirong Gong, Yaling Shen
Combination therapy of two or more drugs has gradually become of outmost importance in cancer treatment. Cabazitaxel (CTX) is a taxoid drug and tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is a member of TNF superfamily. In this study, we prepared TRAIL-modified and CTX-loaded polymer micelle (TRAIL-M-CTX). This nanoparticle was self-assembled from biodegradable amphiphilic copolymers, monomethoxyl poly(ethylene glycol)-b-poly(DL-lactide) (mPEG-PLA) and COOH-PEG-PLA, via a nanoprecipitation method and were modified with the TRAIL protein, resulting in a particle size of 39...
June 10, 2018: Journal of Biomaterials Science. Polymer Edition
Feng Su, Yuandou Wang, Xue Liu, Xin Shen, Xingjian Zhang, Quansheng Xing, Lihong Wang, Yangsheng Chen
Carboxymethyl chitosan-graft-polylactide (CMCS-PLA) and carboxymethyl chitosan (CMCS) hydrogels were prepared by using 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride/N-hydroxysuccinimide (EDC/NHS) as crosslinking agent and catalyst at room temperature. The biocompatibility of the hydrogels was evaluated with the aim of assessing their potential as drug carrier. Various aspects of biocompatibility were considered, including MTT assay, agar diffusion test, release of lactate dehydrogenase (LDH), hemolytic test, plasma recalcification time (PRT), and dynamic clotting time...
June 7, 2018: Journal of Biomaterials Science. Polymer Edition
Shuang Deng, Xian Li, Wangkai Yang, Kewen He, Xu Ye
A series of injectable in situ cross-linking hyaluronic acid/carboxymethyl cellulose based hydrogels (HA/CMC) was prepared via disulfide bonds by the oxidation of dissolved oxygen. The results showed that HA/CMC hydrogels exhibited tunable gelling time, appropriate rheology properties, high swelling ratio, good stability, and sustained drug release ability. The gelling time of HA/CMC hydrogels ranged from 1.4 to 7.0 min, and the values of the storage modulus, complex shear modulus, dynamic viscosity, and yield stress of HA3/CMC3 hydrogel were about 5869 Pa, 5870 Pa, 587 Pa·s, and 1969 Pa, respectively...
June 4, 2018: Journal of Biomaterials Science. Polymer Edition
Ryan J Miller, Cheook Y Chan, Arjun Rastogi, Allison M Grant, Christina M White, Nicole Bette, Nicholas J Schaub, Joseph M Corey
A promising component of biomaterial constructs for neural tissue engineering are electrospun fibers, which differentiate stem cells and neurons as well as direct neurite growth. However, means of protecting neurons, glia, and stem cells seeded on electrospun fibers between lab and surgical suite have yet to be developed. Here we report an effort to accomplish this using cell-encapsulating hydrogel fibers made by interfacial polyelectrolyte complexation (IPC). IPC-hydrogel fibers were created by interfacing acid-soluble chitosan (AsC) and cell-containing alginate and spinning them on bundles of aligned electrospun fibers...
June 3, 2018: Journal of Biomaterials Science. Polymer Edition
Xueqing Zou, Xiaozhen Xiao, Shixiong Zhang, Jiajun Zhong, Yulin Hou, Liqiong Liao
Herein, a photo-switchable and thermal-enhanced fluorescent hydrogel has been fabricated from N-isopropylacrylamide (NIPAAm) with a mixture of water-soluble acryloyl-α-cyclodextrin/acryloyl-α-cyclodextrin-spiropyran (acryloyl-α-CD/ acryloyl-α-CD-SP) as cross-linkers. The physical properties, photochromic properties, and fluorescent behavior of the hydrogel were characterized. The fluorescence emission of the hydrogel can be reversibly switched 'on/off' by UV/visible light irradiation, and meanwhile the fluorescence intensity can be enhanced by increasing the temperature above the volume phase transition temperature (VPTT) of the hydrogel...
June 1, 2018: Journal of Biomaterials Science. Polymer Edition
Jianrong Wu, Yuanchong Zhao, Jin Wang, Tianxue You, Nan Huang
Here we report the anticoagulant property of Sulfonated Silk Fibroin (SSF) which was improved by sulfonation method. Chlorosulfonic acid was applied to modify the Silk Fibroin (SF) anticoagulant property by the preparation of the SSF. The SSF was prepared in the new technology that 50°C, 0.2 g SF/ml chlorosulfonic acid and 15 h were optimized with the reaction temperature, special concentration ratio of the SF to the chlorosulfonic acid and the certain reaction time, respectively. Then the SF reaction solution was dialyzed, and freeze-dried to form the SSF...
May 30, 2018: Journal of Biomaterials Science. Polymer Edition
Hye Ri Lee, Tae Ho Kim, Se Heang Oh, Jin Ho Lee
Atopic dermatitis (AD) is a chronic inflammatory skin disease resulting pruritic, erythema, edema, excoriation, and thickening of the skin, and thus leads to significant impairment in the patient's life. The objective of this study is to develop a steroid drug [prednisolone (PS)]-loaded coatable hydrogel for the treatment of AD. PS-loaded hydrogel was composed of PVA entrapped in mildly crosslinked alginate (PS-loaded PVA/ALG hydrogel). The PS concentration to be loaded in the hydrogel that takes AD efficacy without cell necrosis was determined from the cytotoxicity test using human dermal fibroblasts...
May 23, 2018: Journal of Biomaterials Science. Polymer Edition
Chunyan Wang, Shengnan Wang, Yuanyi Yang, Zhuo Jiang, Yi Deng, Shaoli Song, Weizhong Yang, Zhi-Gang Chen
In this study, we develop an osteopromotive polyetheretherketone (PEEK) implant decorated with silk fibroin and bone forming peptide, in which the surface of bioinert PEEK implant is firstly sulfonated to form a three-dimensional, porous topography and then is functionalized with silk fibroin via spin-coating process and peptide decoration. The bio-test results show that cells on the functional bioinert implants exhibit better cell adhesion, proliferation and spreading, when compared with the uncoated ones...
May 23, 2018: Journal of Biomaterials Science. Polymer Edition
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"