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Journal of Biomaterials Science. Polymer Edition

Elbay Malikmammadov, Tugba Endogan Tanir, Aysel Kiziltay, Vasif Hasirci, Nesrin Hasirci
Biodegradable polymers have met withan increasing demand in medical usage over the last decades. One of such polymers is poly(ε-caprolactone) (PCL), whichis a polyester that has been widely used in tissue engineering field for its availability, relatively inexpensive price and suitability for modification. Its chemical and biological properties, physicochemical state, degradability and mechanical strengthcan be adjusted, and therefore,it can be usedunderharsh mechanical, physical and chemical conditions without significant loss of its properties...
October 20, 2017: Journal of Biomaterials Science. Polymer Edition
Jeong Eun Song, Nirmalya Tripathy, Se Rom Cha, Sung Hyun Jeon, Soon Yong Kwon, Dong Sam Suh, Gilson Khang
An ideal tissue-engineered scaffold must provide sufficient porosity to allow free movement of cells, nutrients, and oxygen for proper cell growth and further maintenance. Owing to variation in pore sizes and shapes of as-fabricated scaffold, the amount of oxygen available for the cells attached to the scaffold and transfer of by-products and excrement will be different, which ultimately results in cell activity.Thus, optimizing pore size and porosity of a scaffold for a specific tissue regeneration are one of the key highlights, which should be considered while designing a scaffold as well as choosing a specific cell type...
October 19, 2017: Journal of Biomaterials Science. Polymer Edition
Fengjuan Zou, Runrun Li, Jianjun Jiang, Xiumei Mo, Guofeng Gu, Zhongwu Guo, Zonggang Chen
The collagen-chitosan complex with a three-dimensional nanofiber structure was fabricated to mimic native ECM for tissue repair and biomedical applications. Though the three-dimensional hierarchical fibrous structures of collagen-chitosan composites could provide more adequate stimulus to facilitate cell adhesion, migrate and proliferation, and thus have the potential as tissue engineering scaffolding, there are still limitations in their applications due to the insufficient mechanical properties of natural materials...
October 19, 2017: Journal of Biomaterials Science. Polymer Edition
Cheng-Mei Liu, Xiao-Hong He, Rui-Hong Liang, Wei Liu, Wen-Li Guo, Jun Chen
This study aims to analyze the effect of physicochemical properties of alginate-high methoxyl pectin (HMP)complexes on their performance as drug delivery systems.Rheology, textural propertiesand swelling behavior of alginate-HMP complexes were determined. HMP alone showed weak gelling ability.As ratio of alginate increased, gel capability, hardness and adhesiveness of gels increased, but swelling rate decreased. Bovine serum albumin (BSA) was used as a model drug and entrapped in the alginate-HMP beads. Morphology of beads was correlated with adhesiveness...
October 17, 2017: Journal of Biomaterials Science. Polymer Edition
Shuang Huang, Yajian Li, Xinning Wang, Xin Ma, Xu Zhang
Transplantation of mesenchymal stem cells (MSCs) is promising for treatment of acute kidney injury (AKI), but their therapeutic effects are often limited under normal conditions. In this study, we prepared the co-gels of decellularized vascular matrix and collagen, and investigated whether the co-gels increase the therapeutic potentials of MSCs on AKI. In vitro studies indicated that the co-gels enhanced the paracrine effects of MSCs, and significantly reduced the apoptosis of MSCs under oxidative environments...
October 13, 2017: Journal of Biomaterials Science. Polymer Edition
Baoming Gong, Shaohua Cui, Yun Zhao, Yongtao Sun, Qian Ding
In the study, the low-cycle fatigue behaviors of 3D-printed poly lactic acid (PLA) scaffolds with 60% porosity and two kinds of geometrical pores were investigated under strain-controlled loading. The obtained Δεa-Nf curves were fitted by Coffin-Manson relation. The mechanical stability of the porous structure under cyclic loading was studied. Both kinds of specimens undergo the strain softening after the initial cyclic hardening. The scaffold with circular pore exhibits stable resistance to the fatigue damage which is desirable for bone repairing...
October 12, 2017: Journal of Biomaterials Science. Polymer Edition
Linjing Jing, Li Chen, Haitao Peng, Mizhi Ji, Yi Xiong, Guoyu Lv
Owing to the good degradability and biocompatibility of polyphosphoesters (PPEs), the aim of the current study was to investigate a novel degradable composite of nano-hydroxyapatite/poly(amino acid) (n-HA/PAA) with cyclophosphate (CPE) via in situ melting polymerization to improve the degradation of n-HA/PAA. The structure of each composite was characterized via Fourier transform infrared spectroscopy, X-ray diffraction, and X-ray photoelectron spectroscopy. The degradation properties were studied in terms of the weight loss and pH in a phosphate-buffered saline (PBS) solution, while the surface morphology was examined using a scanning electron microscope-energy dispersive spectrometer (SEM-EDS) after soaking the surface in simulated body fluid (SBF)...
October 11, 2017: Journal of Biomaterials Science. Polymer Edition
Kondareddy Cherukula, M Nurunnabi, Yong Yeon Jeong, Yong-Kyu Lee, In-Kyu Park
Despite the introduction of many efficient post-consolidation therapies for complete relapse in leukemia patients, many patients suffer from relapse. Reactive oxygen species (ROS) are considered an important parameter in the immunosuppression of AML, where they suppress the cytotoxic action of immune cells such as NK cells and T cells. This study demonstrates a way to achieve effective inhibition of immunosuppression by loading the drug histamine dihydrochloride (HDC) onto graphene quantum dots (GQDs) using hyaluronic acid (HA) as a targeting moiety for K-562 cells...
October 10, 2017: Journal of Biomaterials Science. Polymer Edition
Mei Zhang, Yali Ma, Rongjun Li, Jiehui Zeng, Ziqi Li, Yajun Tang, Dahui Sun
In this study, we fabricated recombinant human bone morphogenetic protein-2 (rhBMP-2)loaded Poly(lactic-co-glycolic acid) (PLGA) microspheres with core-shell structuresand particle sizes ranging from 2.5-8μm by coaxial electrospraying. The manufacturing process of core-shell microspheres by coaxial electrosprayingis simpler than thatwith other methods, and a smaller diameter can be obtained. The microspheres were analyzed by environmental scanning electron microscopy, transmission electron microscopy (TEM), and laser scanning confocal microscopy (LSCM)...
October 9, 2017: Journal of Biomaterials Science. Polymer Edition
Shaghayegh Baghaie, Mohammad T Khorasani, Ali Zarrabi, Jamal Moshtaghian
In this work, hydrogel membranes were developed based on poly vinyl alcohol (PVA), starch (St), and chitosan (Cs) hydrogels with nano Zinc oxide (nZnO). PVA/St/Cs/nZnO hydrogel membranes were prepared by freezing-thawing cycles, and the aqueous PVA/St solutions were prepared by dissolving PVA in distilled water. After the dissolution of PVA, starch was mixed, and the mixture was stirred. Then, chitosan powder was added into acetic acid, and the mixture was stirred to form a chitosan solution. Subsequently, Cs, St and PVA solutions were blended together to form a homogeneous PVA/St/Cs ternary blend solution...
October 7, 2017: Journal of Biomaterials Science. Polymer Edition
Yahong Zhao, Jiahuan Gong, Changmei Niu, Ziwei Wei, Jiaqi Shi, Guohui Li, Yumin Yang, Hongbo Wang
Graphene (Gr) has been made of various forms used for repairing peripheral nerve injury with favorable electroactivity, however, graphene-based scaffolds in peripheral nerve regeneration are still rarely reported due to the difficulty of realizing uniform dispersion of graphene and electroactive materials at nanoscale as well as lacking biocompatibility. In this paper, graphene-silk fibroin (SF) composite nanofiber membranes with different mass ratios were prepared via electrospinning. Microscopic observation revealed that electrospun Gr/SF membranes had a nanofibrous structure...
September 30, 2017: Journal of Biomaterials Science. Polymer Edition
Shingo Kawabata, Katsuya Kawai, Satoshi Somamoto, Kazuo Noda, Yoshitaka Matsuura, Yoko Nakamura, Shigehiko Suzuki
Silk-elastin is a recombinant protein polymer with repeating units of silk and elastin blocks. This novel wound healing promoting material has the ability to self-assemble from a liquid to a gel. We have already reported that an aqueous solution of silk-elastin has the potential to accelerate wound healing; however, there are several problems in applying silk-elastin in the clinical setting. To solve these problems, we developed a silk-elastin sponge that is easy to use in the clinical setting. In the present study, we examined whether the wound healing effect of the silk-elastin sponge is equal to the aqueous solution of silk-elastin in vivo...
September 28, 2017: Journal of Biomaterials Science. Polymer Edition
Yeung Kyu Yeon, Hae Sang Park, Jung Min Lee, Ji Seung Lee, Young Jin Lee, Md Tipu Sultan, Ye Bin Seo, Ok Joo Lee, Soon Hee Kim, Chan Hum Park
Open reduction with internal fixation is commonly used for the treatment of bone fractures. However, postoperative infection associated with internal fixation devices (intramedullary nails, plates, and screws) remains a significant complication, and it is technically difficult to fix multiple fragmented bony fractures using internal fixation devices. In addition, drilling in the bone to install devices can lead to secondary fracture, bone necrosis associated with postoperative infection. In this study, we developed bone clip type internal fixation device using three- dimensional (3D) printing technology...
September 22, 2017: Journal of Biomaterials Science. Polymer Edition
Chi Bum Ahn, Youngjo Kim, Sung Jean Park, Yongsung Hwang, Jin Woo Lee
Poly(propylene fumarate) (PPF) has known to be a good candidate material for cartilage tissue regeneration because of its excellent mechanical properties during its degradation processes. Here, we describe the potential application of PPF-based materials as 3D printing bioinks to create macroporous cell scaffolds using micro-stereolithography (MSTL). To improve cell-matrix interaction of seeded human chondrocytes within the PPF-based 3D scaffolds, we immobilized arginine-glycine-aspartate (RGD) peptide onto the PPF scaffolds...
September 20, 2017: Journal of Biomaterials Science. Polymer Edition
Hong Su, Guoneng Xue, Changrong Ye, Yan Wang, Ansha Zhao, Nan Huang, Jingan Li
Surface modification by immobilizing biomolecules has been widely proved to enhance biocompatibility of cardiovascular implanted devices. Here, we aimed at developing a multifunctional surface that not only provides good hemocompatibility but also functions well in capturing circulating endothelial progenitor cells (EPCs) in the blood flow to improve the surface endothelialization. In the present work, we preferred to chemically co-immobilize (Michael addition and Schiff base reaction) the anti-CD133 (EPC-specific antibody) and fucoidan (EPC-mobilization factor, which also contribute to better hemocompatibility) onto a polydopamine (PDA) film which is famous for its stability and endothelial cell (EC) compatibility...
September 19, 2017: Journal of Biomaterials Science. Polymer Edition
Seungil Kim, Yannick Leandre Traore, Jae Sang Lee, Ji-Heung Kim, Emmanuel A Ho, Song Liu
New amphiphilic PEGylated poly(aspartic acid) graft copolymer (PASP-PEG-Ph) was synthesized as a nanocarrier for intravaginal drug delivery of poorly water-soluble drugs. PASP-PEG-Ph self-assembled into negatively charged spherically shaped nanoparticles in the presence of pH 4.5 and pH 7.0 vaginal fluid simulants with a diameter of approximately 200 nm as evidenced by Zeta-potentiometer, scanning electron microscope (SEM), dynamic light scattering (DLS) analysis. A significant number of stable NPs could be maintained at pH 4...
September 12, 2017: Journal of Biomaterials Science. Polymer Edition
Yu Wei, Jingxun Zhang, Xiantao Feng, Dongyin Liu
Zwitterionic copolymers keep good resistance to platelet adhesion and nonspecific protein adsorption. In this study, A block copolymer brushes consisting of carboxybetaine methacrylate (CBMA) and glycidyl methacrylate (GMA) were grafted from silicon wafers via surface-initiated atom transfer radical polymerization (SI-ATRP),and then the Arg-Glu-Asp-Val (REDV) peptide was attached to the polymer brush via an reactive epoxy group of the P(GMA) unit to improve endothelial cells (ECs) selectivity. These modified surfaces were evaluated with scanning electron microscopy (SEM), atomic force microscopy (AFM), attenuated total reflectance-Fourier transform infrared spectra (ATR-FTIR), X-ray photoelectron spectroscopy (XPS), and static water contact angle measurement (WCA)...
September 11, 2017: Journal of Biomaterials Science. Polymer Edition
Kazuhiko Ishihara, Mingwei Mu, Tomohiro Konno
We summarize the development and evaluation of new type of phospholipid polymers as a solubilizer for poorly water-soluble compounds. That is, a water-soluble and amphiphilic poly(2-methacryloyloxyethyl phosphorylcholine-random-n-butyl methacrylate) contains 30 mol% hydrophilic 2-methacryloyloxyethyl phosphorylcholine units and its weight-averaged molecular weight is around 5.0 × 10(4). When the polymer is dissolved in an aqueous medium, a large portion of hydrophobic n-butyl methacrylate units assemble, forming polymer aggregates...
September 10, 2017: Journal of Biomaterials Science. Polymer Edition
Vasanthan Ravichandran, Rajani Kant Rai, Venkitasamay Kesavan, A Jayakrishnan
A new approach for the design and synthesis of cyclic N-halamine polymers having anti-bacterial activity based on a vinyl derivative of tyrosine-derived hydantoin is reported. The synthesis of N-halamine polymers generally involves the chemical modification of 5,5'-disubstituted hydantoin to introduce polymerizable vinyl moieties thereby restricting the halogen capture only on the amide nitrogen. Here we show the possibility of synthesizing vinyl monomers of N-halamine from α-amino acids wherein both the amide and imide nitrogens are available for halogen capture...
September 7, 2017: Journal of Biomaterials Science. Polymer Edition
M C R Miranda, F G Prezotti, F A Borges, N R Barros, B S F Cury, R D Herculano, E M Cilli
Natural rubber latex biomedical (NRLb) obtained from the rubber tree Hevea brasiliensis has shown great potential in biomedicine and biomaterial applications. NRLb has been utilized as a physical barrier against infectious agents and in the controlled release of drugs and extracts. In the present work, NRLb was polymerized in a lyophilizer using different volumes of water to control the resultant membrane porosity and characterized regarding the surface morphology, water vapour permeability (WVP), mechanical properties, haemolytic activity and cytotoxicity...
September 6, 2017: Journal of Biomaterials Science. Polymer Edition
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