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Journal of Biomaterials Science. Polymer Edition

Paula Christina Mattos Dos Santos, Paulo Emilio Feuser, Priscilla Barreto Cardoso, Bethina Trevisol Steiner, Emily da Silva Córneo, Rahisa Scussel, Alexandre da Cas Viegas, Ricardo Andrez Machado-de-Ávila, Claudia Sayer, Pedro Henrique Hermes de Araújo
Magnetic nanoparticles encapsulated in biocompatible and biodegradable polymeric matrices are promising materials for biomedical applications, such as transport of antitumoral drugs and cancer treatment by hyperthermia. In this study, biobased poly(thioether-ester), PTEe, was obtained by thiol-ene polymerization and superparamagnetic nanoparticles, MNPs, were successfully incorporated in PTEe nanoparticles by miniemulsification followed by solvent evaporation. MNPs-PTEe nanoparticles with average diameter around 150 nm presented superparamagnetic behavior as confirmed by magnetization curves analysis...
January 4, 2019: Journal of Biomaterials Science. Polymer Edition
Longyi Piao, Yongmeng Li, Hanwen Zhang, Jing Jiang
Micelles are promising a nano drug carrier for cancer therapy. However, their application is often limited due to the instability of them in vivo. Herein, we reported the development of stereocomplex micelle (SCM) based on amphiphilic dextran-block-polylactide (Dex-b-PLA) that could improve the stability of micelles, reduce the early release of loaded drugs and target the breast cancer through the enhanced permeability and retention (EPR) effect for enhanced breast cancer therapy. The SCM were fabricated from the equimolar mixture of the enantiomeric Dex-b-PLA copolymers...
January 3, 2019: Journal of Biomaterials Science. Polymer Edition
Mehdi Khanmohammadi, Shinji Sakai, Masahito Taya
Hydrogel microcapsules having the ability to promote cell adhesion and proliferation are a useful tool for fabricating tissue in vitro. The present study explored the effects of two anionic polysaccharide hydrogel membranes which have an impact on the adhesiveness, morphology and growth of cells. Microcapsules were made by coating a cell-laden gelatin microparticle with a hydrogel membrane produced from modified hyaluronic acid or alginate possessing phenolic hydroxyl moieties (HA-Ph or Alg-Ph respectively) via a horseradish peroxidase-catalyzed crosslinking reaction...
December 28, 2018: Journal of Biomaterials Science. Polymer Edition
Donnelly E Patrick, Laurianne Imbert, Culley L Kirsty, Russell F Warren, Tony Chen, Maher A Suzanne
The optimal solution for articular cartilage repair has not yet been identified, in part because of the challenges in achieving integration with the host. Coatings have the potential to transform the adhesive features of surfaces, but their application to cartilage repair has been limited. Self-assembled monolayer of phosphonates (SAMPs) have been demonstrated to increase the adhesion of various immortalized cell types to metal and polymer surfaces, but their effect on primary chondrocyte adhesion has not been studied...
December 27, 2018: Journal of Biomaterials Science. Polymer Edition
Jiaxing Zhong, Qiuju Tang, Yanshan Ju, Yonghui Lin, Xiaowen Bai, Junyi Zhou, Haipeng Luo, Zhentao Lei, Zaizai Tong
Herein, for rate-tunable controlled release, pH and redox dual responsive polymeric vesicles were constructed based on host-guest interaction between a water soluble pillar[5]arene (WP5) and a paraquat-containing block copolymer (BCP) in water. The yielding polymeric vesicles can be further applied in the controlled release of a hydrophilic model drug, doxorubicin hydrochloride (DOX). The drug release rate is regulated depending on the type of single stimulus or the combination of two stimuli. Meanwhile, DOX-loaded polymeric vesicles present anticancer activity in vitro comparable to free DOX under the studied conditions, which may be important for applications in the therapy of cancers as a controlled-release drug carrier...
December 27, 2018: Journal of Biomaterials Science. Polymer Edition
Xiaowei Yuan, Mei Zhang, Yilong Wang, He Zhao, Dahui Sun
Microparticles (MPs) exhibit fast dissolution, characterized by a burst drug release pattern. In the present work, we prepared core-shell MPs of simvastatin (SIM) and zein with chitosan (CS) and nano-hydroxyapatite (nHA) as a drug carrier using the coaxial electrospray deposition method. The morphology, formation and in vitro osteogenic differentiation of these MPs were studied. The synthetic MPs have a diameter of about 1 μm and they are composed of non-toxic natural materials. They provide an effective way to enable long-term sustained-release activity, which is controlled by their double layer structures...
December 21, 2018: Journal of Biomaterials Science. Polymer Edition
Lan-Xin Lü, Xiao-Feng Zhang, Anthony J Deegan, Gao-Feng Liang, Hong-Ning Yang, Shu-Qun Hu, Xian- Liang Yan, Ning-Ping Huang, Tie Xu
Having advantageous biocompatibility and osteoconductive properties known to enhance the osteogenic differentiation of mesenchymal stem cells (MSCs), hydroxyapatite (HA) is a commonly used material for bone tissue engineering. What remains unclear, however, is whether HA holds a similar potential for stimulating the osteogenic differentiation of MSCs to that of a more frequently used osteogenic-inducing medium (OIM). To that end, we used PHBV electrospun nanofibrous scaffolds to directly compare the osteogenic capacities of HA with OIM over MSCs...
December 17, 2018: Journal of Biomaterials Science. Polymer Edition
Fan Chen, Yi Li, Ye Fu, Yu Hou, Yuanwei Chen, Xianglin Luo
In order to obtain target/redox shell cross-linked micelles (TCM), copolymers poly(ε-caprolactone)-poly(2-hydroxyethyl methacrylate/methacrylate-alpha lipoic acid) and poly(ε-caprolactone)-poly(2-hydroxyethyl methacrylate/methacrylate-folate, PCL-P(HEMA/HEMA-LA) and PCL-P(HEMA/HEMA-FA) were designed and synthesized. The copolymers PCL-P(HEMA/HEMA-LA) could form reduction-sensitive cross-linked micelles (CM) by using a catalytic amount of DTT. The micelles maintained high stability against dilution but were destroyed in 10 mM dithiothreitol (DTT)...
December 17, 2018: Journal of Biomaterials Science. Polymer Edition
L R Cajero-Zul, F A López-Dellamary, S Gómez-Salazar, M Vázquez-Lepe, R Vera-Graziano, M R Torres-Vitela, M A Olea-Rodríguez, S M Nuño-Donlucas
Nanocomposites of functionalized carbon nanotubes (CNTsf ) as nanofillers, and a copolymer of star-shaped poly(ε-caprolactone) (stPCL) and poly(ethylene glycol) (PEG) as a polymeric matrix were synthesized, characterized, and their resistance to the growth of Staphylococcus aureus and Pseudomonas aeruginosa was evaluated. CNTsf contain hydroxyl, carboxyl and acyl chloride groups attached to their surface. Nanocomposites were prepared by mixing CNTsf to a solution of stPCL-PEG copolymer. Raman and FT-IR spectroscopies confirm the functionalization of carbon nanotubes (CNTs)...
December 17, 2018: Journal of Biomaterials Science. Polymer Edition
Fangqing Yin, Lanfang Lin, Shijuan Zhan
Gelatin (GA), hyaluronic acid (HA) and cellulose nanocrystals (CNC) are promising materials for skin wound care. In this study the GA-HA-CNC hydrogels were prepared by cross-linking and freeze-drying. The composition and mechanism of GA-HA-CNC hydrogels were confirmed by FTIR. The morphology and pore size were obtained by SEM. We accessed the physical property from rheological results and swelling ratio. NIH-3T3 cells were inoculated into the hydrogels and cultured for different days, then we analyzed the cytotoxicity of the prepared hydrogels by CCK-8 methods and live/dead pictorial diagram using staining kits...
December 17, 2018: Journal of Biomaterials Science. Polymer Edition
Jilan Wang, Ye Bi, Hongyan Ruan, Guoqing Sun, Xianping Cui, Xinlin Yang, Chengkun Qin
A kind of tumor targeting nitric oxide donor nanoparticle with brushes is described in this paper. The poly(4-vinylphenylboronic acid) polymeric brush, which shows glucose and pH dual responsiveness, endows the ability of hollow S-nitrosothiols nanoparticle to accurate recognition and binding with the sialic acid over-expressed type tumor cells, such as HepG2 and MCF-7 cells. In vitro experiments, including cells capture and release experiments, confocal fluorescence microscope characterization, cytotoxicity assay with different cells, demonstrate the selective recognition and the controlled NO release to kill tumor cells for these S-nitrosothiols nanoparticles...
December 6, 2018: Journal of Biomaterials Science. Polymer Edition
Xiaoxia Fan, Haitao Peng, Hong Li, Yonggang Yan
The aim of this study was to evaluate the thermal properties and in vivo interface performance of poly(amino acid) (PAA) and a composite containing PAA, hydroxyapatite (HA), and calcium sulfate (CS), with respect to their suitability for skull repair. Biocompatibility was evaluated by implantation of materials into muscles of rabbits for eight weeks. Skull repair was assessed by implanting PAA, the compact PAA/HA/CS composite (c-PAA/HA/CS), and a one-side-porous PAA/HA/CS composite (p-PAA/HA/CS) into rabbit calvarial defects...
December 6, 2018: Journal of Biomaterials Science. Polymer Edition
Shuzhen Luo, Fang Liu, Biao Yu, Jingwei He
A new urethane dimethacrylate TMA was synthesized through a typical urethane reaction. TMA was used to replace 1,6-bis(methacryloxy-2-ethoxycarbonyl- amino)-2,4,4- trimethylhexane (UDMA) in UDMA based composite partially or totally to prepare TMA containing composites. Critical properties of TMA containing composites were investigated. 2,2-bis[4(2-hydroxy-3-methacryloy- propyloy)phenyl]propane (Bis-GMA) based and UDMA based composites were used as references. FT-IR and 1 H-NMR confirmed the structure of TMA...
December 5, 2018: Journal of Biomaterials Science. Polymer Edition
Bas van Bochove, Dirk W Grijpma
Photo-crosslinked synthetic biodegradable polymer networks are highly interesting materials for utilization in biomedical applications such as drug delivery, cell encapsulation and tissue engineering scaffolds. Varying the architecture, chemistry, degree of functionalization and molecular weight of the macromer precursor molecules results in networks with a wide range of physical- and mechanical properties, crosslinking densities, degradation characteristics and thus in potential applications. Photo-crosslinked networks can easily be prepared and have the possibility to entrap a wide range of (biologically active) substances and cells...
November 29, 2018: Journal of Biomaterials Science. Polymer Edition
Yingda Ma, Jian Chen, Jian Li, Wenyan Han, Yamin Chai, Tingting Wang, Qian Zhang, Lichun Wang, Weichao Wang, Zhexiang Wang, Lailiang Ou
Adsorbents are widely used in hemoperfusion for bilirubin removal. However, their performance is often compromised by the presence of plasma proteins. In this study, the bilirubin adsorption capacity of polyvinyl alcohol microspheres (PVAm) functionalized with different amino-alkane ligands has been investigated, with the aim of gaining binding selectivity over albumin. Octylamine-functionalized PVA microspheres (PVAm-8) exhibited an excellent adsorption capacity for bilirubin (75% and 3.95 mg/mL in PBS vs 72% and 3...
November 28, 2018: Journal of Biomaterials Science. Polymer Edition
Shida Li, Wenxiu Wei, Weiping Jia, Lechen Zhao, Hongmei Xu, Feilong Zhou, Li Zhu, Zhimei Song, Sijia Feng, Runliang Feng
A copolymeric micelle formulation of itraconazole (ITR-M) was prepared using linear-dendritic monoallyloxy poly (ethylene glycol)-b-poly (ε-caprolactone) (APEG-PCL) as drug carrier materials. DL and EE values of ITR-M were 5.70 ± 0.12 % and 91.30 ± 1.90 %, respectively. The micelle formulation enhanced the ITR solubility up to 30.42 μg/mL. In vitro release of ITR from the ITR-M was mainly drug diffusion process followed by the copolymer's degradation. ITR-M showed similar anti-Candida albicans activity to that of crude ITR although its release of ITR was slow and continuous...
November 28, 2018: Journal of Biomaterials Science. Polymer Edition
Yu Zhong, Xingtao Chen, Haitao Peng, Zhengwen Ding, Yonggang Yan
The novel Ca-zeolite/poly(amino acid) (CaY/PAA) composites for bone substitute applications with hemostatic activity were prepared using the in situ melting polymerization method. In this study, Ca-zeolite (CaY) loaded with Ca2+ was obtained from Y-type zeolite (NaY) by ion-exchange method. The properties of the CaY/PAA composites and PAA, including composition, structure, compressive strength, in vitro degradability in phosphate-buffered solution (PBS), bioactivity, cytocompatibility and in vitro coagulation tests were characterized and investigated...
November 24, 2018: Journal of Biomaterials Science. Polymer Edition
Ayako Washio, Chiaki Kitamura, Yasuhiko Tabata
Gelatin hydrogel sponges incorporating bioactive glasses (Gel-BG) were fabricated. We evaluated the characteristics of Gel-BG as scaffolds from the perspective of their mechanical properties and the formation of hydroxyapatite by the incorporation of bioactive glasses (BG). In addition, the Gel-BG degradation and the profile of fibroblast growth factor-2 (FGF-2) release from the Gel-BG were examined. Every Gel-BG showed an interconnected pore structure with the pore size range of 180-200 µm. The compression modulus of sponges incorporating BG increased...
November 23, 2018: Journal of Biomaterials Science. Polymer Edition
Hui Yu, Xiaojing Chen, Jie Cai, Dongdong Ye, Yuxiao Wu, Peifeng Liu
Long-term antibacterial medical dressings can prevent infection as skin wounds heal. In this study, we used the hydrophobic antibacterial drug amoxicillin as a model to prepare drug-loaded nanomicelles using a film dispersion-hydration method, and drug-loaded nanomicelles were coaxially electrospun into nanofiber to create a novel nanomicelle-in-nanofiber (NM-in-NF) drug delivery system. Scanning electron microscopy and transmission electron microscopy were used to characterize the morphology of nanomicelles and nanofibers...
November 19, 2018: Journal of Biomaterials Science. Polymer Edition
Xuebin Ma, Shuai Liu, Hejun Tang, Rong Yang, Bo Chi, Zhiwen Ye
Due to the syringeability of precursor solution and convenience of open surgical treatment, injectable hydrogels have gained growing attention in drug delivery application. For load-bearing tissue, the excellent mechanical property is an important requirement for delivery vehicles to resist external stress and loads. Herein, we prepared mechanically robust injectable hydrogels (HA/γ-PGA hydrogels for short) using methacrylate-functionalized hyaluronic acid and poly (γ-glutamic acid) via photopolymerization...
November 13, 2018: Journal of Biomaterials Science. Polymer Edition
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