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Journal of Biomaterials Science. Polymer Edition

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https://www.readbyqxmd.com/read/28157422/scalable-preparation-of-poly-ethylene-glycol-grafted-sirna-loaded-lipid-nanoparticles-using-a-commercially-available-fluidic-device-and-tangential-flow-filtration
#1
Yu Sakurai, Tomoya Hada, Hideyoshi Harashima
While a number of siRNA delivery systems have been developed, the methods used in their preparation are not suitable for large-scale production. We herein report on methodology for the large-scale preparation of liposomal siRNA using a fluidic device and tangential flow filtration. A number of studies have appeared on the use of fluidic devices for preparing and purifying liposomes, but no systematic information regarding appropriate membrane type of commercially available apparatus is available. The findings reported herein indicate that, under optimized conditions, a microfluidic device and tangential flow filtration can be used to produce siRNA lipid nanoparticles with the same characteristics as traditional ones'...
February 3, 2017: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/28077032/iodine-responsive-poly-hema-pvp-hydrogel-for-self-regulating-burst-free-extended-release
#2
Jinku Xu, Peili Zhao, Yongchun Zhang
Swollen hydrogels with extended iodine release kinetics is highly desirable for burn and scald treatment. In this paper semi-interpenetrating poly (HEMA-PVP) hydrogels were prepared by radical polymerization followed by thermo-treatment to crosslink its PVP component. Incorporation of PVP component endows the hydrogels responsive to loaded iodine undergoing a reversible shrunken/swollen volume transition. This resulted in a self-regulating iodine release model, in which shrunken hydrogel at high iodine loading decreased drug diffusion thereby reducing burst release, and then gradually swollen hydrogel as drug release ensures rapid release of dissociated drug from strong affinity sites on hydrogel backbone, achieving a burst-free extended release...
January 30, 2017: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/28132586/development-of-gd3n-c80-encapsulated-redox-nanoparticles-for-high-performance-magnetic-resonance-imaging
#3
Zhenyu Gao, Yusuke Nakanishi, Shoko Noda, Haruka Omachi, Hisanori Shinohara, Hiroyuki Kimura, Yukio Nagasaki
As novel magnetic resonance imaging (MRI) contrast agent, gadofullerene encapsulated redox nanoparticles (Gd3NPs) were prepared by encapsulation of Gd3N@C80 in the core of core-shell-type polymer micelles composed of original polyamine with a reactive oxygen species (ROS)-scavenging ability. Because Gd3NPs possess biocompatible PEG shell with a smaller size (ca. 50 nm), they had high colloidal stability in a physiological environment, and showed low cytotoxicity. Specific accumulation of Gd3NPs in a tumor was confirmed in tumor-bearing mice after systemic administration...
January 28, 2017: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/28112036/interaction-between-two-parallel-plates-covered-with-a-polyelectrolyte-brush-layer-in-an-electrolyte-solution
#4
Hiroyuki Ohshima
An approximate analytic expression is derived for the interaction energy between two parallel plates covered with a polyelectrolyte brush layer in an electrolyte solution. The interaction energy has three components: electrostatic interaction energy between two brush layers before and after their contact, steric interaction energy between two brush layers after their contact, and the van der Waals interaction energy between the cores of the plates. It is shown that these three components are of the same order of magnitude and contribute equally to the total interaction energy between two polyelectrolyte-coated plates in an electrolyte solution...
January 22, 2017: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/28105891/friction-of-sodium-alginate-hydrogel-scaffold-fabricated-by-3-d-printing
#5
Qian Yang, Jian Li, Heng Xu, Shijun Long, Xuefeng Li
A rapid prototyping technology, formed by three-dimensional (3-D) printing and then crosslinked by spraying Ca(2+) solution, is developed to fabricate a sodium alginate (SA) hydrogel scaffold. The porosity, swelling ratio, and compression modulus of the scaffold are investigated. A friction mechanism is developed by studying the reproducible friction behavior. Our results show that the scaffold can have 3-D structure with a porosity of 52%. The degree of swelling of the SA hydrogel scaffold is 8.5, which is nearly the same as bulk SA hydrogel...
January 20, 2017: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/28056727/preparation-and-mineralization-of-a-biocompatible-double-network-hydrogel
#6
Quanzhu Yang, Fangfang Song, Xueqing Zou, Liqiong Liao
Double network (DN) hydrogels have shown favorable toughness and strength and been harnessed as scaffolding materials in tissue engineering, particularly, mineralized DN hydrogels may be potential scaffolds in bone tissue engineering. In this paper, DN hydrogels were fabricated from poly(ethylene glycol) diacrylate (PEGDA) and methacrylated poly(γ-glutamic acid) (mPGA). This DN hydrogel not only showed excellent mechanical properties but also good cytocompatibility as evidenced by the characterizations in terms of swelling ratio, mechanical strength/modulus, and cytotoxicity...
January 20, 2017: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/28051909/in-vitro-heterogeneous-degradation-of-alginate-and-its-validation-of-different-molecular-weight-on-blood-bio-compatibility
#7
Mengxue Xu, Chao Feng, Juan Wang, Xuqian Lang, Guixue Xia, Xiaoping Yu, Qiuxia Ji, Xiaojie Cheng, Ming Kong, Ya Liu, Xiguang Chen
In the present work, sodium alginate (ALG) was degraded by heterogeneous phase acid degradation. The molecular weight distribution of ALG after degradation was close to homogenization. Then the blood bio-compatibility of ALG with different molecular weights (ALG-0h 50,075, ALG-0.5h 20,680, ALG-2h 13,170 and ALG-96h 1170 kDa) was evaluated in vitro and vivo. The human umbilical vein endothelial cells were used to assess the cytotoxicity of ALGs, ALG-0.5h and ALG-2h exhibited greater increment in percentage of cell viability comparing with ALG-0h and ALG-96h...
January 18, 2017: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/28054502/enhanced-ph-stability-cell-viability-and-reduced-degradation-rate-of-poly-l-lactide-based-composite-in-vitro-effect-of-modified-magnesium-oxide-nanoparticles
#8
Jinjun Yang, Xiuxiang Cao, Yun Zhao, Liang Wang, Bei Liu, Junping Jia, Hui Liang, Minfang Chen
The modified MgO nanoparticles (m-MgO-NPs) by a copolymer containing the malic acid and low molecular weight poly(L-lactide) (poly(L-lactide-co-malic acid), PLMA) have been successfully prepared. MgO nanoparticles (MgO-NPs) were coated by the PLMA and m-MgO-NPs were uniformly dispersed in the PLLA matrix to a novel biocomposite material (PLLA/m-MgO-NPs) with more excellent interface bonding and uniformer dispersion, compared to the PLLA/MgO-NPs. Compared to neat PLLA and PLLA/MgO-NPs film, the m-MgO-NPs not only shown the obvious neutralization effect on the acidic solution in the degradation of the PLLA and better hydrophilicity, but also exhibited the higher cell viability and decrease the toxicity to the cell in the degradation process of PLLA in vitro...
January 16, 2017: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/28044473/synthesis-characterization-and-in-vitro-evaluation-of-targeted-gold-nanoshelled-poly-d-l-lactide-co-glycolide-nanoparticles-carrying-anti-p53-antibody-as-a-theranostic-agent-for-ultrasound-contrast-imaging-and-photothermal-therapy
#9
Li Xu, Caifeng Wan, Jing Du, Hongli Li, Xuesong Liu, Hong Yang, Fenghua Li
Breast cancer is the leading cause of cancer-related deaths in women and earlier detection can substantially reduce deaths from breast cancer. Polymers with targeted ligands are widely used in the field of molecular ultrasound imaging and targeted tumor therapy. In our study, the nanotheranostic agent was fabricated through filling perfluoropropane (C3F8) into poly(d,l-lactic-co-glycolic acid) nanoparticles (PLGA NPs), followed by the formation of gold nanoshell on the surface, then conjugated with anti p53 antibody which has high specificity with the p53 protein overexpressing in breast cancer...
January 16, 2017: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/28081670/oxidation-and-degradation-of-polypropylene-transvaginal-mesh
#10
Anne D Talley, Bridget R Rogers, Vladimir Iakovlev, Russell F Dunn, Scott A Guelcher
Polypropylene (PP) transvaginal mesh (TVM) repair for stress urinary incontinence (SUI) has shown promising short-term objective cure rates. However, life-altering complications have been associated with the placement of PP mesh for SUI repair. PP degradation as a result of the foreign body reaction (FBR) has been proposed as a contributing factor to mesh complications. We hypothesized that PP oxidizes under in vitro conditions simulating the FBR, resulting in degradation of the PP. Three PP mid-urethral slings from two commercial manufacturers were evaluated...
January 13, 2017: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/28027693/patupilone-loaded-poly-l-glutamic-acid-graft-methoxy-poly-ethylene-glycol-micelle-for-oncotherapy
#11
Jing Yan, Dawei Zhang, Haiyang Yu, Lili Ma, Mingxiao Deng, Zhaohui Tang, Xuefei Zhang
Patupilone, an original natural anti-cancer agent, also known as epothilone B or Epo906, has shown promise for the treatment of a variety of cancers, however, the systematic side effects of patupilone significantly impaired its clinical translation. Herein, patupilone-loaded PLG-g-mPEG micelles were prepared. Patupilone was grafted to a poly(L-glutamic acid)-graft-methoxy-poly(ethylene glycol) (PLG-g-mPEG) by Steglich esterification reaction to give PLG-g-mPEG/Epo906 that could self-assemble to form patupilone-loaded micelles (Epo906-M)...
January 12, 2017: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/28025903/antibacterial-coating-on-in-line-suction-respiratory-catheter-to-inhibit-the-bacterial-biofilm-formation-using-renewable-cardanyl-methacrylate-copolymer
#12
Denial Mahata, Ahindra Nag, Santi M Mandal, Golok B Nando
Health-care materials associated with infections are very common in hospital admitted patients. There are generally infected by contact with the catheter or other multipurpose devices which are contacted with microbes. The respiratory infections associated with the pathogens having strong biofilm forming ability on catheter surface, causes life-threatening in every year. Therefore, a catheter coating material is of great interest which inhibits the biofilm formation of pathogens on a catheter to prevent respiratory infections...
January 6, 2017: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/28001498/evaluation-of-the-osteoconductive-potential-of-poly-propylene-carbonate-nano-hydroxyapatite-composites-mimicking-the-osteogenic-niche-for-bone-augmentation
#13
Qin Zou, Jianguo Liao, Jidong Li, Yubao Li
Nano-hydroxyapatite (n-HA) reinforced poly(propylene carbonate) (PPC) composites were prepared for bone repair and reconstruction. The effects of reinforcement on the morphology, mechanical properties and biological performance of n-HA/PPC composites were investigated. The surface morphology and mechanical properties of the composites were characterized by scanning electron microscopy (SEM) and universal material testing machine. The analytical data showed that good incorporation and dispersion of n-HA crystals could be obtained in the PPC matrix at a 30:70 weight ratio...
December 29, 2016: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/27931160/preparation-of-hollow-core-shell-fe3o4-graphene-oxide-composites-as-magnetic-targeting-drug-nanocarriers
#14
Junmei Wang, Jianjun Fang, Pan Fang, Xian Li, Shijie Wu, Wenjing Zhang, Sufang Li
A main challenge for anticancer drugs is that the drugs can not arrive the cancer tissue at right time. In this work, a magnetic targeting nanoparticle based on hollow Fe3O4/graphene oxide (Fe3O4/GO) was developed as a potential tumor targeting drug carriers. The morphology results showed the Fe3O4 nanoparticles were uniformly wrapped by graphene oxide. After coating with graphene oxide, the Fe3O4/GO showed a higher saturation magnetization of 71.47 emu g(-1) as compared to neat Fe3O4 nanoparticles. The drug loading and releasing experiment indicated the obtained Fe3O4/GO has a good loading capacity of of 0...
December 28, 2016: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/28142329/preparation-of-gelatin-nanospheres-incorporating-quantum-dots-and-iron-oxide-nanoparticles-for-multimodal-cell-imaging
#15
Yuki Murata, Jun-Ichiro Jo, Yasuhiko Tabata
The objective of this study is to prepare a multimodal probe which can simultaneously visualize cells by optical and magnetic resonance (MR) imaging modalities. Gelatin nanospheres incorporating quantum dots (QD) and iron oxide nanoparticles (IONP) were prepared by the conventional emulsion method. The percentage of QD and IONP incorporated in gelatin nanospheres was changed by the concentrations of gelatin and glutaraldehyde used. However, the apparent size and surface zeta potential were hardly changed. Gelatin nanospheres incorporating QD and IONP were treated with octa-arginine (R8) of a cell-penetrating peptide...
April 2017: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/28134036/photocrosslinked-tyramine-substituted-hyaluronate-hydrogels-with-tunable-mechanical-properties-improve-immediate-tissue-hydrogel-interfacial-strength-in-articular-cartilage
#16
Patrick E Donnelly, Tony Chen, Anthony Finch, Caroline Brial, Suzanne A Maher, Peter A Torzilli
Articular cartilage lacks the ability to self-repair and a permanent solution for cartilage repair remains elusive. Hydrogel implantation is a promising technique for cartilage repair; however for the technique to be successful hydrogels must interface with the surrounding tissue. The objective of this study was to investigate the tunability of mechanical properties in a hydrogel system using a phenol-substituted polymer, tyramine-substituted hyaluronate (TA-HA), and to determine if the hydrogels could form an interface with cartilage...
April 2017: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/28125949/preparation-and-characterization-of-a-chitosan-galactosylated-hyaluronic-acid-heparin-scaffold-for-hepatic-tissue-engineering
#17
Jinyong Fan, Jun Yang
Cell culture microenvironment and hepatocyte-specific three-dimensional tissue-engineering scaffold play important roles for bioartificial liver devices. In the present study, highly porous sponge scaffolds composed of chitosan (CS) and galactosylated hyaluronic acid (GHA, galactose moieties were covalently coupled with hyaluronic acid through ethylenediamine), were prepared by freezing-drying technique. Because the growth factors specifically bind to heparin with a high affinity and biological stability of the growth factors are modulated by heparin...
April 2017: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/28125380/extrusion-based-3d-printing-of-poly-propylene-fumarate-scaffolds-with-hydroxyapatite-gradients
#18
Jordan E Trachtenberg, Jesse K Placone, Brandon T Smith, John P Fisher, Antonios G Mikos
The primary focus of this work is to present the current challenges of printing scaffolds with concentration gradients of nanoparticles with an aim to improve the processing of these scaffolds. Furthermore, we address how print fidelity is related to material composition and emphasize the importance of considering this relationship when developing complex scaffolds for bone implants. The ability to create complex tissues is becoming increasingly relevant in the tissue engineering community. For bone tissue engineering applications, this work demonstrates the ability to use extrusion-based printing techniques to control the spatial deposition of hydroxyapatite (HA) nanoparticles in a 3D composite scaffold...
April 2017: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/28105892/molecularly-imprinted-cryogel-membranes-for-mitomycin-c-delivery
#19
Pınar Öncel, Kemal Çetin, Aykut Arif Topçu, Handan Yavuz, Adil Denizli
In this study, cryogel-based implantable molecularly imprinted drug delivery systems were designed for the delivery of antineoplastic agent. Mitomycin C imprinted poly(2-hydroxyethyl methacrylate-N-methacryloyl-l-glutamic acid) cryogel membranes were produced by free-radical bulk polymerization under partially frozen conditions. The membranes were characterized by swelling tests, Fourier transform infrared spectroscopy, scanning electron microscopy, surface area measurements and in vitro hemocompatibility tests...
April 2017: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/28081674/in-vivo-lifetime-and-anti-cancer-efficacy-of-doxorubicin-loaded-nanogels-composed-of-cinnamoyl-poly-%C3%AE-cyclodextrin-and-cinnamoyl-pluronic-f127
#20
Dong Youl Yoon, Jin-Chul Kim
Nanogel composed of rhodamine B isothiocyanate-labeled cinnamoyl polymeric β cyclodextrin and cinnamoyl Pluronic F127 was prepared by taking advantage of their self-assembling property in aqueous phase. The in vivo lifetime of the nanogel in the blood circulation system of hairless mouse was determined by fluorescence imaging method using rhodamine B isothiocyanate as a fluorescence probe, and it was more than 192 h. The in vivo clearance of doxorubicin loaded in the nanogel was observed by the same fluorescence imaging method...
April 2017: Journal of Biomaterials Science. Polymer Edition
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