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Journal of Biomaterials Science. Polymer Edition

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https://www.readbyqxmd.com/read/28726563/mechanically-strong-and-ph-responsive-carboxymethyl-chitosan-graphene-oxide-polyacrylamide-nanocomposite-hydrogels-with-fast-recoverability
#1
Yang Chen, Hongqiu Wang, Junrong Yu, Yan Wang, Jing Zhu, Zuming Hu
The biocompatible, quickly recoverable, mechanically strong and tough polymer hydrogels has great potential for biomedical applications. A novel carboxymethyl chitosan (CMCTs)/graphene oxide (GO)/polyacrylamide (PAM) nanocomposite (NC) hydrogel with excellent mechanical performance was synthesized through a facile, one-pot free radical polymerization, using GO nanosheets as the crosslink centers instead of toxic organic molecules. The content of GO nanosheets and CMCTs has great influence on the mechanical properties of CMCTs/GO/PAM NC hydrogels...
July 20, 2017: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/28722543/comparison-of-ovalbumin-and-ovalbumin-epitope-peptide-for-transdermal-delivery-and-vaccination-mediated-by-the-photothermal-effect-of-gold-nanorods
#2
Aung Thu Haine, Yuji Miyamoto, Taishi Higashi, Keiichi Motoyama, Hidetoshi Arima, Takuro Niidome
Transdermal protein delivery is a powerful and attractive method for protein therapy and dermal vaccination compared with other administrations. However, this delivery method is restricted by the low permeability of the stratum corneum, a hydrophobic barrier that restricts the entry of hydrophilic molecules such as proteins. In this study, we developed an improved gel patch system carrying ovalbumin and ovalbumin epitope peptide, and then compared their permeability into the skin. First, the gel patch was placed on mouse skin to allow contact with the polymer coated gold nanorods and then irradiated by a continuous-wave laser...
July 19, 2017: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/28722515/construction-of-a-plga-based-targeted-sirna-delivery-system-for-treatment-of-osteoporosis
#3
Deniz Sezlev Bilecen, Jose Carlos Rodriguez-Cabello, Hasan Uludag, Vasif Hasirci
Osteoporosis is a systemic skeletal disorder which occurs when the bone turnover balance is disrupted. With the identification of the genes involved in the pathogenesis of the disease, studies on development of new osteoporosis treatments has intensified. RNA interference (RNAi) mechanism uses short interfering RNA (siRNA) to knockdown disease related gene expression as a treatment approach. Targeting while protecting siRNA against hydrolysis by nucleases in vivo is, however, challenging. The maintenance of therapeutic plasma level is also hampered by the clearance of siRNA from the body...
July 19, 2017: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/28707508/design-and-fabrication-of-porous-biodegradable-scaffolds-a-strategy-for-tissue-engineering
#4
Vahideh Raeisdasteh Hokmabad, Soodabeh Davaran, Ali Ramazani, Roya Salehi
Current strategies of tissue engineering are focused on the reconstruction and regeneration of damaged or deformed tissues by grafting of cells with scaffolds and biomolecules. Recently, much interest is given to scaffolds which are based on mimic the extracellular matrix that have induced the formation of new tissues. To return functionality of the organ, the presence of a scaffold is essential as a matrix for cell colonization, migration, growth, differentiation and extracellular matrix deposition, until the tissues are totally restored or regenerated...
July 14, 2017: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/28705112/pcl-tcp-wet-spun-scaffolds-carrying-antibiotic-loaded-microspheres-for-bone-tissue-engineering
#5
Elbay Malikmammadov, Tugba Endogan Tanir, Aysel Kiziltay, Vasif Hasirci, Nesrin Hasirci
Scaffolds produced for tissue engineering applications are proven to be promising alternatives to be used in healing and regeneration of injured tissues and organs. In this study, porous and fibrous poly(ε-caprolactone) (PCL) scaffolds were prepared by wet spinning technique and modified by addition of tricalcium phosphate (TCP) and by immobilizing gelatin onto fibers. Meanwhile, gelatin microspheres carrying Ceftriaxone sodium (CS), a model antibiotic, were added onto the scaffolds and antimicrobial activity of CS was investigated against Escherichia coli (E...
July 14, 2017: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/28701073/the-role-of-rhfgf-2-soaked-polymer-membrane-for-enhancement-of-guided-bone-regeneration
#6
Sang-Hoon Lee, Young-Bum Park, Hong-Seok Moon, June-Sung Shim, Han-Sung Jung, Hyung Jun Kim, Moon-Kyu Chung
The purposes of this study are to confirm the role of Fibroblast Growth Factor-2 (FGF-2) in bone regeneration by adding various concentrations of FGF-2 to the collagen membrane and applying it to the Biphasic Calcium Phosphate (BCP) bone graft site for guided bone regeneration, to explore the potential of collagen membrane as FGF-2 carrier, and to determine the optimum FGF concentration for enhancement of bone regeneration. Four bone defects of 8mm in diameter were created in 18 New Zealand rabbit calvaria...
July 12, 2017: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/28699828/glioma-targeted-delivery-strategy-of-doxorubicin-loaded-liposomes-by-dual-ligand-modification
#7
Wei Han, Guangfu Yin, Ximing Pu, Xianchun Chen, Xiaoming Liao, Zhongbing Huang
The blood-brain barrier (BBB) is the protective parclose of brain safety, but it is also the main obstacle of the drug delivery to cerebral parenchyma, which hamper therapy for brain diseases. In this work, a glioma targeted drug delivery system was developed through loading doxorubicin into Angiopep-2 and TAT peptide dual-modified liposomes (DOX-TAT-Ang-LIP). Low-density lipoprotein receptor-related protein-1 (LRP1) was one receptor overexpressed on both BBB and glioma cytomembranes. Angiopep-2, a specific ligand of LRP1, exhibited high LRP1 binding efficiency...
July 12, 2017: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/28697688/plumbago-auriculata-leaf-extract-mediated-agnps-and-its-activities-as-antioxidant-anti-tb-and-dye-degrading-agents
#8
Neeraj Jaryal, Harpreet Kaur
In the present work, silver nanoparticles have been biosynthesized by utilizing the alcoholic extract of Plumbago auriculata. The optimization of reaction conditions was carried out by monitoring the reactions with the help of UV- visible absorption spectroscopy. The characterization of AgNP was carried out by infrared spectroscopy, transmission electron microscopy (TEM) and X-Ray diffraction (XRD) studies. The biogenic AgNPs were tested against Mycobacterium tuberculosis using Microplate Almar Blue assay (MABA) and their antioxidant activity was also evaluated...
July 11, 2017: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/28696185/in-vitro-evaluation-of-antisense-oligonucleotide-functionalized-core-shell-nanoparticles-loaded-with-%C3%AE-tocopherol-succinate
#9
Ebru Kilicay, Zeynep Karahaliloglu, Pınar Alpaslan, Baki Hazer, Emir Baki Denkbas
Antisense oligonucleotide (ASO)-conjugated-α-tocopherol succinate (TCS)-loaded-poly(lactic acid)-g-poly(ethylene glycol) nanoparticles (ASO-TCS-PLA-PEG NPs), with the ratio of polymer/TCS of 10:2.5, 10:5, 10:7 (w/w) were prepared for targeting cancer therapy. The amphiphilic PLA, amino terminated PEG graft copolymers were synthesized by ring opening polymerization reaction. Nanoparticles were produced by using double emulsion (w/o/w) solvent evaporation method. ASO-TCS-PLA-PEG NPs demonstrated satisfactory encapsulation and loading efficiency and size distribution...
July 11, 2017: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/28696181/growth-factor-sequestration-and-enzyme-mediated-release-from-genipin-crosslinked-gelatin-microspheres
#10
Paul A Turner, Jeffrey S Thiele, Jan P Stegemann
Controlled release of growth factors allows the efficient, localized, and temporally-optimized delivery of bioactive molecules to potentiate natural physiological processes. This concept has been applied to treatments for pathological states, including chronic degeneration, wound healing, and tissue regeneration. Peptide microspheres are particularly suited for this application because of their low cost, ease of manufacture, and interaction with natural remodeling processes active during healing. The present study characterizes gelatin microspheres for the entrapment and delivery of growth factors, with a focus on tailored protein affinity, loading capacity, and degradation-mediated release...
July 11, 2017: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/28693380/the-binary-complex-of-poly-pegma-co-maa-hydrogel-and-plga-nanoparticles-as-a-novel-oral-drug-delivery-system-for-ibuprofen-delivery
#11
Qing Shang, Sijin Huang, Aixin Zhang, Jia Feng, Song Yang
To improve the bioavailability of ibuprofen (IBU), we developed a novel binary complex of poly(PEGMA-co-MAA) hydrogel and IBU-loaded PLGA nanoparticles (IBU-PLGA NPs@hydrogels) as an oral intestinal targeting drug delivery system (OIDDS). The IBU-loaded PLGA NPs and pH-sensitive hydrogels were obtained via the solvent evaporation method and radical polymerization, respectively. The final OIDDS was obtained by immersing the hydrogel chips in the IBU-loaded PLGA NPs solutions (pH 7.4) for 3 d. The size distribution and morphology of cargo-free NPs were studied by laser granularity analyzer and transmission electron microscope (TEM)...
July 11, 2017: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/28691869/composite-electrospun-nanofibers-of-reduced-graphene-oxide-grafted-with-poly-3-dodecylthiophene-and-poly-3-thiophene-ethanol-and-blended-with-polycaprolactone
#12
Raana Sarvari, Somaye Sattari, Bakhshali Massoumi, Samira Agbolaghi, Younes Beygi-Khosrowshahi, Amir Kahaie-Khosrowshahi
In this paper, an effective method was employed for preparation of nanofibers using conducting polymer-functionalized reduced graphene oxide (rGO). First, graphene oxide (GO) was obtained from graphite by Hommer method. GO was reduced to rGO by NaBH4 and covalently functionalized with a 3-thiophene acetic acid (TAA) by an esterification reaction to reach 3-thiophene acetic acid-functionalized reduced graphene oxide macromonomer (rGO-f-TAAM). Afterward, rGO-f-TAAM was copolymerized with 3-dodecylthiophene (3DDT) and 3-thiophene ethanol (3TEt) to yield rGO-f-TAA-co-PDDT (rGO-g-PDDT) and rGO-f-TAA-co-P3TEt (rGO-g-PTEt), which were confirmed by Fourier transform infrared spectra...
July 10, 2017: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/28657862/a-poly-glycerol-sebacate-based-photo-thermo-dual-curable-biodegradable-and-biocompatible-polymer-for-biomedical-applications
#13
Min Wang, Dong Lei, Zenghe Liu, Shuo Chen, Lijie Sun, Ziying Lv, Peng Huang, Zhongxing Jiang, Zhengwei You
Due to its biomimetic mechanical properties to soft tissues, excellent biocompatibility and biodegradability, poly (glycerol sebacate) (PGS) has emerged as a representative bioelastomer and been widely used in biomedical engineering. However, the typical curing of PGS needs high temperature (>120 °C), high vacuum (>1 Torr), and long duration (>12 h), which limit its further applications. Accordingly, we designed, synthesized and characterized a photo/thermo dual curable polymer based on PGS. Treatment of PGS with 2-isocyanatoethyl methacrylate without additional reagents readily produced a methacrylated PGS (PGS-IM)...
June 28, 2017: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/28657493/three-dimensional-graphene-oxide-coated-polyurethane-foams-beneficial-to-myogenesis
#14
Yong Cheol Shin, Seok Hee Kang, Jong-Ho Lee, Bongju Kim, Suck Won Hong, Dong-Wook Han
The development of three dimensional (3D) scaffolds for promoting and stimulating cell growth is one of the greatest concerns in biomedical and tissue engineering. In the present study, novel biomimetic 3D scaffolds composed of polyurethane (PU) foam and graphene oxide (GO) nanosheets were designed, and their potentials as 3D scaffolds for skeletal tissue regeneration was explored. The GO-coated PU foams (GO-PU foams) were characterized by scanning electron microscopy and Raman spectroscopy. It was revealed that the 3D GO-PU foams consisted of an interconnected foam-like network structure with an approximate 300 μm pore size, and the GO was uniformly distributed in the PU foams...
June 28, 2017: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/28657452/tuning-of-the-surface-biological-behavior-of-poly-l-lactide-based-composites-by-the-incorporation-of-polyelectrolyte-complexes-for-bone-regeneration
#15
Xuehong Wang, Jie Wei, Jianding Chen, Songchao Tang
Poly(L-lactide)(PLLA)-based composites have been widely used for tissue regeneration. Novel polyelectrolyte complexes (PECs) consisted of carboxymethyl starch sodium (CMS) and chitosan oligosaccharide (COS) was fabricated and evaluated. The results suggested that the CMS/COS-PECs (CC-PECs) distinguished from the original polymers alone, presenting an amorphous structure. Then, the CC-PECs/PLLA composites were prepared by varying the relative amount of CC-PECs in the PLLA-matrix, demonstrated by means of the surface morphology, hydrophilicity, water uptake, in vitro degradability and primary cell responses...
June 28, 2017: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/28639511/in-memory-of-professor-teiji-tsuruta-great-mentor-in-polymeric-biomaterials
#16
Akihiko Kikuchi, Nobuhiko Yui, Stuart L Cooper, Kazunori Kataoka
No abstract text is available yet for this article.
June 22, 2017: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/28598722/improvement-of-mechanical-strength-and-osteogenic-potential-of-calcium-sulfate-based-hydroxyapatite-3-dimensional-printed-scaffolds-by-%C3%AE%C2%B5-polycarbonate-coating
#17
Beom-Su Kim, Sun-Sik Yang, Ho Park, Se-Hwan Lee, Young-Sam Cho, Jun Lee
Powder-based three-dimensional (3D) printing is an excellent method to fabricate complex-shaped scaffolds for tissue engineering. However, their lower mechanical strength restricts their application in bone tissue engineering. Here, we created a 3D-printed scaffold coated with a ε-polycaprolactone (PCL) polymer solution (5 and 10 w/v %) to improve the mechanical strength of the scaffold. The 3D scaffold was fabricated from calcium sulfate hemihydrate powder (CaSO4-1/2 H2O), transformed into hydroxyapatite (HAp) by treatment with a hydrothermal reaction in an NH4H2PO4 solution...
June 21, 2017: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/28604249/sustained-release-of-melatonin-from-tio2-nanotubes-for-modulating-osteogenic-differentiation-of-mesenchymal-stem-cells-in-vitro
#18
Min Lai, Ziyang Jin, Qiang Tang, Min Lu
To control the sustained release of melatonin and modulate the osteogenic differentiation of mesenchymal stem cells (MSCs), melatonin was firstly loaded onto TiO2 nanotubes by direct dropping method, and then a multilayered film was coated by a spin-assisted layer-by-layer technique, which was composed of chitosan (Chi) and gelatin (Gel). Successful fabrication was characterized by field emission scanning electron microscopy, atomic force microscope, X-ray photoelectron spectroscopy and contact angle measurement, respectively...
June 19, 2017: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/28589787/conditioned-medium-from-the-three-dimensional-culture-of-human-umbilical-cord-perivascular-cells-accelerate-the-migration-and-proliferation-of-human-keratinocyte-and-fibroblast
#19
Min Ho Kim, Wen Hao Wu, Jee Hyun Choi, Ji Hyun Kim, Seok-Ho Hong, Jin Hyun Jun, Yong Ko, Jong Hun Lee
Previous studies have reported that the conditioned medium (CM) of bone marrow-mesenchymal stem cells (BM-MSCs) stimulate the migration and proliferation of cell types involved in the wound healing process. However, these studies only show MSC-CM effects that were obtained using a two-dimensional (2D) culture. Recently, a three-dimensional (3D) culture has been considered to be a more physiologically appropriate system than the 2D culture. In addition, it has been shown that the procurement of BM-MSC is invasive, and other sources of MSC are thus being explored...
June 18, 2017: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/28627324/preparation-characterization-and-in-vitro-cytotoxicity-of-chitosan-hydrogels-containing-silver-nanoparticles
#20
Bożena Tyliszczak, Anna Drabczyk, Sonia Kudłacik-Kramarczyk, Agnieszka Sobczak-Kupiec
Hydrogels, chitosan as well as silver nanoparticles become in recent years materials characterized by a great interest. In present paper hydrogel based on chitosan and containing mention type of nano-sized particles have been synthesized by means of photopolymerization. Sorption capacity in selected liquids as well as behavior in simulated body fluid (such as Ringer's liquid) have been determined. Particularly attention was paid to the studies on toxicity of the hydrogels in relation to the epidermal cells as well as on their impact on growth of selected strain of bacteria (Escherichia coli)...
June 17, 2017: Journal of Biomaterials Science. Polymer Edition
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