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Journal of Biomaterials Science. Polymer Edition

Fei He, Hongjing Jiao, Yu Tian, Libo Zhao, Xiaozhu Liao, Zengjie Fan, Bin Liu
The complicated synthesis procedure and limited preparation size of hydrogel inhibit its clinical application. Therefore, a facile preparation method for large-size hydrogel is required. In this study, a series of curcumin (Cur)/polyvinyl alcohol (PVA) hydrogel in a large size with different Cur concentrations is prepared by a facile physical-chemical crosslinking. The physicochemical properties, antibacterial performance and accelerating wound healing ability are evaluated with the aim of attaining a novel and effective wound dressing...
December 13, 2017: Journal of Biomaterials Science. Polymer Edition
Zhi Chen, Ting Wang, Qing Yan
Development of a delivery system which can effectively carry hydrophobic drugs and have pH response is becoming necessary. Here we demonstrate that through preparation of β-cyclodextrin polymer (β-CDP), a hydrophobic drug molecule of ibuprofen (IBU) was incorporated into our prepared β-CDP inner cavities, aiming to improve the poor water solubility of IBU. A core-shell capsule structure has been designed for achieving the drug pH targeted and sustained release. This delivery system was built with polysaccharide polymer of Sodium alginate (SA), sodium carboxymethylcellulose (CMC) and hydroxyethyl cellulose (HEC) by physical cross-linking...
December 8, 2017: Journal of Biomaterials Science. Polymer Edition
Young-Gwang Ko, Young-Jin Kim, Won Ho Park, Donghwan Cho, Ho Yun Chung, Oh Hyeong Kwon
To maintain the original function of a specific tissue for therapeutic tissue engineering, an advanced cell culture surface for repeat cell proliferation is necessary. We designed a novel cell proliferation and rapid harvesting surface by combining nonwoven nanofiber mat and a thermo-responsive polymer. Nanofibrous poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) mats were fabricated by the electrospinning technique. A poly(N-isopropylacrylamide) (PNIPAM) thermo-responsive layer was grafted on the PHBV nanofiber mat by electron beam irradiation...
December 7, 2017: Journal of Biomaterials Science. Polymer Edition
Samad Hosseini Sadr, Soodabeh Davaran, Effat Alizadeh, Roya Salehi, Ali Ramazani
Great efforts have been made to develop drug carriers with the aim of providing predictable therapeutic response. Moreover, combination therapies have become promising strategies for clinical cancer treatment with synergistic effects. The present study purposed to develop a new stimuli-responsive paramagnetic nanocarrier for the intracellular co-delivery of doxorubicin (DOX) and methotrexate (MTX) to the MCF7 cell line. A novel thermo/pH-sensitive amphiphilic paramagnetic nanocomposite comprised of hydrophobic and biodegradable PCL segments and a hydrophilic biocompatible P(NIPAAm-co-HEMA-co-MAA-co-TMSPMA) block was designed and synthesized by combining the ring opening and free radical polymerization methods...
December 7, 2017: Journal of Biomaterials Science. Polymer Edition
Yeon Ji Kook, Jingwen Tian, Yoo Shin Jeon, Min Jung Choi, Jeong Eun Song, Chan Hum Park, Rui L Reis, Gilson Khang
Scaffolds mimicking structural and chemical characteristics of the native bone tissues are critical for bone tissue engineering. Herein, we have developed and characterized epigallocatechin gallate/duck's feet collagen/hydroxyapatite (EGCG/DC/HAp) composite sponges that enhanced the bone tissue regeneration. The three-dimensional composite sponges were synthesized by loading various amounts (i.e. 1 μM, 5 μM and 10 μM) of EGCG to duck feet derived collagen followed by freeze-drying and then coating with hydroxyapatite...
December 6, 2017: Journal of Biomaterials Science. Polymer Edition
A S Sumayya, G Muraleedhara Kurup
There is an intense interest in developing innovative biomaterials which support the invasion and proliferation of living cells for potential applications in tissue engineering and regenerative medicine. Present study demonstrated the in vivo biocompatibility and toxicity of a macromolecules cross-linked biocomposite scaffold composed of hydroxyapatite, alginate, chitosan and fucoidan abbreviated as HACF. The in vivo biocompatibility and toxicity of HACF scaffold were tested by comparing them with those of a biocompatible surgical metal implant (SMI) in a subcutaneous rat model...
December 5, 2017: Journal of Biomaterials Science. Polymer Edition
Ye Huang, Guangjia Peng, Bin Chen, Ping Yong, Nan Yao, Liming Yang, Rogério P Pirraco, Rui L Reis, Jie Chen
In order to ameliorate the properties of corrosion resistance and achieve applications in anti-biofouling of 316L stainless steel (SS), a sulfated derivative of chitosan was deposited onto stainless steel surface by an electrochemical method. In detail, chitosan-catechol (CS-CT) was synthesized in the hydrochloric acid solution by the Mannich reaction and then electrodeposited on the surface of the polished 316L stainless steel. The chitosan-catechol deposited SS sample was further modified with maleic anhydride and sulfite...
November 24, 2017: Journal of Biomaterials Science. Polymer Edition
Peishan Teo, Xiaowen Wang, Jieying Zhang, Han Zhang, Xin Yang, Yun Huang, Jintian Tang
To find a promising drug carrier to suppress tumor using magnetic induction hyperthermia (MIH) and targeted therapy, two superparamagnetic iron oxide nanoparticles (SPIONs) coated with polyethylene glycol (PEG) and LyP-1, respectively, were prepared and compared. The particle size ranges of PEG-SPIONs and LyP-1-SPIONs were 10~15nm, and 15~20nm, respectively. In FTIR spectra, PEG-SPIONs and LyP-1-SPIONs had strong peaks between 575 and 1630 cm(-1). Specifically, the PEG-SPIONs mainly has peaks in 581 and 1630 cm(-1)...
November 22, 2017: Journal of Biomaterials Science. Polymer Edition
Azizeh-Mitra Yousefi, Byran Smucker, Alex Naber, Cara Wyrick, Charles Shaw, Katelyn Bennett, Sarah Szekely, Carlie Focke, Katherine A Wood
Tissue engineering using three-dimensional porous scaffolds has shown promise for the restoration of normal function in injured and diseased tissues and organs. Rigorous control over scaffold architecture in melt extrusion additive manufacturing is highly restricted mainly due to pronounced variations in the deposited strand diameter upon any variations in process conditions and polymer viscoelasticity. We have designed an I-optimal, split-plot experiment to study the extrudate swell in melt extrusion additive manufacturing and to control the scaffold architecture...
November 22, 2017: Journal of Biomaterials Science. Polymer Edition
Amrita Pal, Chandrashekhar Pathak, Brent Vernon
Animal tissue has an extended history of clinical use in applications like heart valve bioprosthesis devices, cardiovascular surgical applications etc. but often does not last longer after implantation in the body due to rapid unwanted degradation. The goal of this work is to develop novel composite biomaterials by grafting biological tissue with synthetic, biodegradable polymers. In the current research phase, porcine submucosa, ureter and bovine pericardial tissue are grafted with poly DL-lactide (PLA), poly glycolide (PGA) and poly DL-lactide glycolide (PLGA) copolymers...
November 22, 2017: Journal of Biomaterials Science. Polymer Edition
Ya Gao, Yi Xiao, Shiyuan Liu, Jiahui Yu
A novel pH-sensitive polymeric prodrug of camptothecin (CPT) by polymerizing γ-camptothecin-glutamate N-carboxyanhydride (Glu (CPT)-NCA) on boronate ester-linked poly (ethyleneglycol) (PEG) directly via the amine-initiated ring open polymerization (ROP) has been developed. The resulting amphiphilic prodrug (mPEG-BC-PGluCPT) could self-assemble into nanoparticles and encapsulate doxorubicin (Dox) simultaneously in aqueous solution for dual-drug delivery. The formation of polymeric prodrug micelles (mPEG-BC@PGluCPT) was confirmed by the measurements of critical aggregation concentration (CAC), particle size, and morphology observations...
November 17, 2017: Journal of Biomaterials Science. Polymer Edition
Ik Sung Cho, Tooru Ooya
A dynamic hydrogel formulated by mixing a glycol chitosan (GC) and an oxidized dextran (Odex) were studied for protein-controlled release in conjunction with the hydrogel fragmentation. A series of injectable dynamic hydrogels were derived from GC and Odex upon simple mixing without the addition of chemical crosslinking agents. The gelation readily took place at physiological pH and temperature. The influence of the concentration of GC and Odex on the gelation time, mechanical properties, water content, in vitro degradation were investigated...
November 14, 2017: Journal of Biomaterials Science. Polymer Edition
Wenxu Wang, Donghuo Zhong, Yu Lin, Rong Fan, Zhengjun Hou, Xiumei Cao, Yubin Ren
In this study, poly-L-lactic acid (PLLA) micropillar substrates were fabricated to evaluate the influence of topographic substrates on cell morphological and functional characteristics, such as spreading area, voltage-gated calcium channels (VGCCs) and membrane potential. The proliferation, spreading area, perimeter and circularity of SH-SY5Y cells interfaced with different substrates were first investigated. In addition, the cytoskeleton and focal adhesion of a cell as important manifestations of cell morphology were analyzed by immunofluorescence...
November 10, 2017: Journal of Biomaterials Science. Polymer Edition
Minsoo Cho, Seulgi Han, Hyemin Kim, Ki Su Kim, Sei Kwang Hahn
Human parathyroid hormone 1-34 fragment (PTH1-34) has been used as a FDA-approved therapeutics to treat osteoporosis by daily subcutaneous injection. In this work, we successfully developed PTH1-34 conjugated hyaluronic acid (HA) for the transdermal treatment of osteoporosis with improved patient compliance. HA-PTH1-34 conjugate was synthesized by the coupling reaction between aldehyde group introduced to HA and amine group of PTH1-34. After characterization by gel permeation chromatography (GPC) and ELISA, the biological effect of HA-PTH1-34 conjugate on the proliferation of human osteoblast cells was confirmed by in vitro calcium colorimetric assay and cAMP assay...
November 8, 2017: Journal of Biomaterials Science. Polymer Edition
Yu Zhang, Cai-Feng Wan, Jing Du, Qi Dong, Yuan-Yuan Wang, Hong Yang, Feng-Hua Li
Antibody-mediated targeting therapy has been successful in treating patients with breast cancer by improving the specificity and clinical efficacy. In this study, we constructed the human epidermal growth factor receptor-2 (Her2) antibody-conjugated ultrasound contrast agent with lactic-co-glycolic acid (PLGA) as film forming and perfluorocty bromide (PFOB) as internal material, which was coated by gold nanoshell (Her2-PFOB@PLGA@Au), to realize the integration of diagnosis and treatment. The contrast agent was spherical, with the diameter was 256...
November 4, 2017: Journal of Biomaterials Science. Polymer Edition
Yin Lv, Bin Yang, You-Mei Li, Feng He, Ren-Xi Zhuo
In this paper, novel folate-conjugated and redox-responsive crosslinked block copolymer was successfully synthesized for targeted and controlled release of doxorubicin (DOX) to cancer cells. Folate-conjugated poly(ethylene glycol)-b-copolycarbonates (FA-PEG-b-P(MAC-co-DTC)) and methoxy poly(ethylene glycol)-b-copolycarbonates (mPEG-b-P(MAC-co-DTC)) were firstly synthesized by enzymatic method. FA-PEG/mPEG-b-P(MAC-co-DTC)-SS was then obtained by further crosslinking reaction with cystamine. Non-conjugated crosslinked copolymer mPEG-b-P(MAC-co-DTC)-SS- and non-conjugated uncrosslinked copolymer mPEG-b-P(MAC-co-DTC) were also synthesized for comparison...
November 1, 2017: Journal of Biomaterials Science. Polymer Edition
Deepak Kumar Khajuria, Saadath Fathima Zahra, Rema Razdan
The aim of this study was to develop a chitosan-based risedronate/zinc-hydroxyapatite intrapocket dental film (CRZHDF) for applications in the treatment of alveolar bone loss in an animal model of periodontitis. The physical characteristics (folding endurance, pH, mucoadhesive strength, risedronate content and release) of CRZHDF, exhibited results within the limit. X-ray diffraction analysis indicates reduced or disappeared crystallinity of risedronate and zinc-hydroxyapatite in presence of chitosan. Further, FTIR studies revealed stability of CRZHDF and compatibility between risedronate, zinc-hydroxyapatite and chitosan...
October 31, 2017: Journal of Biomaterials Science. Polymer Edition
H Kim, S Kim, H Sah
This study aimed to develop a solvent hydrolysis-based microencapsulation technique that could fabricate PLGA microspheres, while using dimethyl carbonate as a green dispersed solvent. Instead of existing physical solvent removal techniques, a strategy was derived to use a chemical reaction that could transform oil droplets into microspheres. An oil-in-water emulsion was first produced by emulsifying a PLGA/Nile red/progesterone/dimethyl carbonate dispersed phase in an aqueous phase. Adding a NaOH solution into the emulsion led to the decomposition of dimethyl carbonate that partitioned to the water phase...
October 31, 2017: Journal of Biomaterials Science. Polymer Edition
Hyunkyu Lee, Heung-Myong Woo, Byung-Jae Kang
The purpose of this study was to identify the effect of collagen-alginate composition on the size and shape of microbeads and the proliferation and osteogenic properties of microencapsulated canine adipose-derived mesenchymal stem cells (ASCs) in vitro. Canine ASCs were microencapsulated in mixtures of various collagen-alginate compositions using a vibrational technologic encapsulator. The size and shape of the resultant microbeads were measured using a light field microscope and the viability of the microencapsulated canine ASCs was evaluated using a live/dead viability/cytotoxicity kit...
October 30, 2017: Journal of Biomaterials Science. Polymer Edition
Dong-Jin Lim, Hansoo Park
There are currently many basic technologies for the controlled release of therapeutic molecules for the treatment of chronic pathologies such as arthritis, asthma, and diabetes. Examples of such technologies include selectively dissolvable capsules and tablets that are designed to respond to specific stimuli-such as pH, temperature, or specific enzymes-in a time-specific fashion. However, because of the biological variations between different individuals, which contribute to differences in the environments of therapeutic target locations, these technologies are not fully controllable...
October 30, 2017: Journal of Biomaterials Science. Polymer Edition
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