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Current Opinion in Obstetrics & Gynecology

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https://www.readbyqxmd.com/read/29708902/the-case-against-endometrial-ablation-for-treatment-of-heavy-menstrual-bleeding
#1
Michelle Louie, Kelly Wright, Matthew Siedhoff
PURPOSE OF REVIEW: Endometrial ablation is a common treatment for heavy menstrual bleeding, but serious limitations and long-term complications exist. Our purpose is to summarize the use of endometrial ablation devices, potential short-term and long-term complications, cost effectiveness, and quality of life in relation to alternative treatments. RECENT FINDINGS: There is insufficient evidence to strongly recommend one endometrial ablation device over another. Providers should consider and discuss with their patients, complications including risk of future pregnancy, endometrial cancer, and hysterectomy for continued bleeding or pain...
April 27, 2018: Current Opinion in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29697414/the-dilemma-of-aneuploidy-screening-on-low-responders
#2
Scott J Morin, Daniel J Kaser, Jason M Franasiak
PURPOSE OF REVIEW: Preimplantation genetic testing for aneuploidy (PGT-A) has been demonstrated to improve implantation and pregnancy rates and decrease miscarriage rates over standard morphology-based embryo selection. However, there are limited data on its efficacy in patients with diminished ovarian reserve or a poor response to stimulation who may have fewer embryos to select amongst. RECENT FINDINGS: Early findings demonstrate that PGT-A reduces the miscarriage rate and decreases the time to delivery in poor responders...
April 24, 2018: Current Opinion in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29664792/added-value-today-of-hormonal-measurements-in-ovarian-stimulation-in-gonadotropin-releasing-hormone-antagonist-treatment-cycle
#3
Biljana Popovic-Todorovic, Annalisa Racca, Christophe Blockeel
PURPOSE OF REVIEW: Traditional approach of ovarian stimulation monitoring for in-vitro fertilization involves transvaginal sonography and serum estradiol measurements. Accumulating evidence has shown that hormonal evaluations during ovarian stimulation allow individual cycle optimization, moving away from only predicting the risk of ovarian hyperstimulation syndrome, but in addition assessing the impact of ovarian stimulation on endometrial receptivity, quality of oocytes, and subsequently embryos...
April 16, 2018: Current Opinion in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29664790/should-we-consider-telomere-length-and-telomerase-activity-in-male-factor-infertility
#4
Carlos Balmori, Elisa Varela
PURPOSE OF REVIEW: The purpose of this review is to analyze what is known to date about the relation between telomeres and male fertility, and if it is possible for telomeres, or elements related to them, to be used as new prognostic biomarkers in fertility treatment. RECENT FINDINGS: Cells in germ series, including spermatozoids, have longer telomeres (10-20 kb), and do not seem to undergo the shortening that takes place in somatic cells with age as they present telomerase activity...
April 16, 2018: Current Opinion in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29652726/how-new-technical-knowledge-impacts-clinical-approach-to-infertile-patients
#5
Juan A Garcia-Velasco, Emre Seli
No abstract text is available yet for this article.
April 12, 2018: Current Opinion in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29652725/therapeutic-strategies-involving-uterine-stem-cells-in-reproductive-medicine
#6
Michael Simoni, Hugh S Taylor
PURPOSE OF REVIEW: The current review provides an update on recent advances in stem cell biology relevant to female reproduction. RECENT FINDINGS: Stem cells are undifferentiated cells that often serve as a reservoir of cells to regenerate tissue in settings or injury or cell loss. The endometrium has progenitor stem cells that can replace all of the endometrium during each menstrual cycle. In addition, multipotent endometrial cells replace these progenitor cells when depleted...
April 12, 2018: Current Opinion in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29652724/complexities-and-potential-pitfalls-of-clinical-study-design-and-data-analysis-in-assisted-reproduction
#7
George Patounakis, Micah J Hill
PURPOSE OF REVIEW: The purpose of the current review is to describe the common pitfalls in design and statistical analysis of reproductive medicine studies. It serves to guide both authors and reviewers toward reducing the incidence of spurious statistical results and erroneous conclusions. RECENT FINDINGS: The large amount of data gathered in IVF cycles leads to problems with multiplicity, multicollinearity, and over fitting of regression models. Furthermore, the use of the word 'trend' to describe nonsignificant results has increased in recent years...
April 12, 2018: Current Opinion in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29715240/is-gonadotropin-stimulation-bad-for-oocytes
#8
Svend Lindenberg, Gitte J Almind, Frederikke B Lindenberg
PURPOSE OF REVIEW: Gonadotrophin in IVF increases the number of oocytes retrieved, and many doctors regard a high number of oocytes as a measurement of success in IVF. Thus, the dogma of more oocytes provides better IVF success has been broadly accepted. However, some European fertility specialists have argued against this concept, saying fewer eggs might, in some instances, be a better option for the patient. RECENT FINDINGS: The concept of 'one size fits all' stimulation in artificial reproductive technologies is not broadly supported by the current literature...
June 2018: Current Opinion in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29708901/metabolism-of-the-oocyte-and-the-preimplantation-embryo-implications-for-assisted-reproduction
#9
Richard Scott, Man Zhang, Emre Seli
PURPOSE OF REVIEW: To discuss the common aspects of energy generation in the cell, substrate utilization by the oocyte and the preimplantation embryos, metabolic characteristics of the reproductive tract, and how metabolic characteristics of an embryo can be exploited to assess viability. RECENT FINDINGS: Utilization of pyruvate, lactate and glucose by the oocyte and the preimplantation embryo seems to be tightly controlled by the most essential molecular regulatory pathways...
June 2018: Current Opinion in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29708900/fertility-ivf-and-reproductive-genetics
#10
Elisa Varela, Irene Sánchez-de-Puerta, Juan A García-Velasco
PURPOSE OF REVIEW: Telomere attrition and dysfunction has become a well established pathway involved in organismal aging, not only because it imposes a limitation to cell division and therefore, tissue regeneration but also because telomere homeostasis influences other pathways involved in aging. However, the implication of telomere biology in ovarian aging and fertility is barely starting to be unveiled. RECENT FINDINGS: During the last years, mounting evidence in favor of the relationship between the accumulation of short telomeres and ovarian senescence has emerged...
June 2018: Current Opinion in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29664793/extracellular-vesicles-a-promising-tool-for-assessment-of-embryonic-competence
#11
Diego Marin, Richard T Scott
PURPOSE OF REVIEW: Extracellular vesicles have recently emerged as a promising field of research due to their pivotal roles in intercellular communication and potential to serve as biomarkers. This review focuses on extracellular vesicles secreted by the human preimplantation embryo. The most recent findings on embryo-derived extracellular vesicles are described and discussed, as well as current technical challenges to study them. RECENT FINDINGS: So far, only a few studies have addressed extracellular vesicles of embryonic origin and explored their potential as biomarkers for embryo selection...
June 2018: Current Opinion in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29664791/embryo-morphokinetic-characteristics-and-euploidy
#12
Francesca Pennetta, Cristina Lagalla, Andrea Borini
PURPOSE OF REVIEW: The purpose of the current review is to provide an update on time-lapse morphokinetic assessment related to embryo ploidy status. RECENT FINDINGS: The main limitation of the available studies regarding correlation between morphokinetic variables and ploidy is that each embryo is considered as an independent unit whereas recent findings show that embryo kinetics may be affected by patient and ovarian stimulation-related factors, so that clustered data analysis is more appropriate...
June 2018: Current Opinion in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29664789/what-is-new-in-the-management-of-poor-ovarian-response-in-ivf
#13
Alberto Vaiarelli, Danilo Cimadomo, Nicolò Ubaldi, Laura Rienzi, Filippo Maria Ubaldi
PURPOSE OF REVIEW: The management and treatment of patients with poor ovarian response is still a controversial issue in IVF. Increasing evidences demonstrate that the number of oocytes retrieved after a controlled ovarian stimulation (COS) greatly influences the clinical outcome in terms of cumulative live birth per started cycle. For this reason, any COS should aim to optimize the number of oocytes according to the ovarian reserve of the patient. The aim of this review is to provide an overview of new strategies proposed to manage poor responders according to the novel POSEIDON classification...
June 2018: Current Opinion in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29489503/evaluation-of-stillbirth
#14
Jessica M Page, Robert M Silver
PURPOSE OF REVIEW: To review current evidence regarding the most useful tests for evaluation of potential causes of stillbirth. RECENT FINDINGS: Stillbirth remains one of the most devastating obstetric complications. Recent advances include work investigating the highest yield diagnostic tests for determining a cause of death in stillbirths. Placental pathology and fetal autopsy improve the diagnostic yield when combined with maternal clinical history. Additional tools include genetic evaluation, and testing for antiphospholipid antibodies and fetal-maternal hemorrhage based on the clinical scenario...
April 2018: Current Opinion in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29489502/updates-in-fetal-spina-bifida-repair
#15
Yair J Blumenfeld, Michael A Belfort
PURPOSE OF REVIEW: To examine updates in fetal spina bifida surgical repair, as well as promising results emerging from translational medicine. RECENT FINDINGS: Although the Management of Myelomeningocele Study sponsored by the National Institutes of Health helped establish the neonatal benefits of prenatal spina bifida repair via uterine hysterotomy, also known as 'open' fetal surgery, fetoscopic approaches may yield better maternal and obstetric outcomes. SUMMARY: Spina bifida is a severe congenital malformation associated with significant neonatal and childhood morbidity and mortality...
April 2018: Current Opinion in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29489501/prenatal-transplantation-of-human-amniotic-fluid-stem-cells-for-spinal-muscular-atrophy
#16
Shao-Yu Peng, Sheng-Wen S Shaw
PURPOSE OF REVIEW: To review the current medical and stem-cell therapy for spinal muscular atrophy (SMA) and prenatal transplantation of amniotic fluid stem cells in the future. RECENT FINDINGS: SMA is an autosomal recessive inheritance of neurodegenerative disease, which is caused of the mutation in survival motor neuron. The severe-type SMA patients usually die from the respiratory failure within 2 years after birth. Recently, researchers had found that 3-methyladenine could inhibit the autophagy and had the capacity to reduce death of the neurons...
April 2018: Current Opinion in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29489500/prenatal-diagnosis
#17
Jane Chueh
No abstract text is available yet for this article.
April 2018: Current Opinion in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29461297/maternal-fetal-medicine-recent-developments-and-moving-forward
#18
Deirdre J Lyell, Mark Boddy, Martha Rode
No abstract text is available yet for this article.
April 2018: Current Opinion in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29406462/30-years-of-current-opinion-in-obstetrics-and-gynecology-looking-back-and-looking-forward
#19
Jonathan S Berek
No abstract text is available yet for this article.
April 2018: Current Opinion in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29406461/zika-virus-a-public-health-perspective
#20
Nahida Chakhtoura, Rohan Hazra, Catherine Y Spong
PURPOSE OF REVIEW: Zika virus' impact on pregnancy became widely known in 2015 with a dramatic increase in the number of babies born with microcephaly in Recife, Brazil. A mosquito-borne virus resulting in congenital anomalies is unique, and Zika's ability to cause neurological defects on a large scale was a grim reminder of the Rubella epidemic in the 1950s. Over the past 2 years, studies have provided insight on how Zika virus (ZIKV) infects cells and causes disease, but much remains unknown about the long-term risks of Zika exposure on infant growth and development...
April 2018: Current Opinion in Obstetrics & Gynecology
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