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Restorative Neurology and Neuroscience

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https://www.readbyqxmd.com/read/28339414/update-on-the-application-of-optic-nerve-sheath-fenestration
#1
Hui Chen, Qian Zhang, Song Tan, Huazhu Fu, Bradley K Farris, Zhenglin Yang
BACKGROUND: With the ongoing development of surgical procedures and instruments, the safety of optic nerve sheath fenestration (ONSF) has been improved. OBJECTIVE: Through the past three decades, progress has been made in preventing visual loss from chronic optic nerve swelling in idiopathic intracranial hypertension (IIH), secondary intracranial hypertension and local optic nerve diseases. We now review the updated application of ONSF in those diseases. METHODS: The application of ONSF in papilledema due to IIH, secondary intracranial hypertension to cerebral venous sinus occlusion, Cryptococcal meningitis, and intracranial mass or tumors is reviewed...
March 23, 2017: Restorative Neurology and Neuroscience
https://www.readbyqxmd.com/read/28059804/bupivacaine-increases-the-rate-of%C3%A2-motoneuron-death-following-peripheral%C3%A2-nerve-injury
#2
Susanna C Byram, Scott W Byram, Nicholas M Miller, Keith N Fargo
BACKGROUND: Appropriate management of pain after an injury or surgical procedure has been shown to improve patient outcomes. While infrequent, nerve damage resulting from regional anesthesia can be devastating, however the mechanism remains unknown. Local anesthetics are neurotoxic yet are frequently applied to sites where peripheral nerves are regenerating. Therefore, understanding their effects on injured and growing neurons may have important implications for clinical practice. OBJECTIVE: The purpose of this study was to determine if local anesthetics exacerbate the rate of motoneuron death following axotomy...
January 4, 2017: Restorative Neurology and Neuroscience
https://www.readbyqxmd.com/read/28059800/twist-and-turn-into-chronic-disorders-of%C3%A2-consciousness-potential-role-of%C3%A2-the%C3%A2-auditory-stapedial-reflex
#3
Antonino Naro, Rocco Bruno, Antonino Leo, Margherita Russo, Carlo Salviera, Alessia Bramanti, Placido Bramanti, Rocco Salvatore Calabrò
BACKGROUND: Patients suffering from chronic disorders of consciousness (DOC), including minimally conscious state (MCS) and unresponsive wakefulness syndrome (UWS), typically show an awareness impairment paralleled by a significant reflex hyper-excitability, which depend on the cortical deafferentation following brain-damage-induced thalamocortical system deterioration. Nonetheless, recent studies have shown a residual preservation of cortico-subcortical pathways that may sustain residual fragments of awareness in some DOC patients...
January 3, 2017: Restorative Neurology and Neuroscience
https://www.readbyqxmd.com/read/28282845/extrinsic-feedback-and-upper-limb-motor-skill-learning-in-typically-developing-children-and-children-with-cerebral-palsy-review
#4
Maxime T Robert, Krithika Sambasivan, Mindy F Levin
BACKGROUND: Improvment of upper limb motor skills occurs through motor learning that can be enhanced by providing extrinsic feedback. Different types and frequencies of feedback are discussed but specific guidelines for use of feedback for motor learning in typically-developing (TD) children and children with Cerebral Palsy (CP) are not available. OBJECTIVE: Identify the most effective modalities and frequencies of feedback for improving upper limb motor skills in TD children and children with CP...
2017: Restorative Neurology and Neuroscience
https://www.readbyqxmd.com/read/28282844/transcranial-direct-current-stimulation-in%C3%A2-individuals-with-spinal-cord-injury-assessment-of-autonomic-nervous-system-activity
#5
Fabiana Tenório Gomes da Silva, Rodrigo Alberto Vieira Browne, Camila Bonin Pinto, Faddi Ghassan Saleh Velez, Eryvaldo Sócrates Tabosa do Egito, Jeferson Tafarel Pereira do Rêgo, Marília Rodrigues da Silva, Paulo Moreira Silva Dantas, Felipe Fregni
BACKGROUND: We hypothesized in this study that transcranial direct current stimulation (tDCS) of primary motor cortex could exert top-down modulation over subcortical systems associated with autonomic control and thus be useful to revert some of the dysfunctional changes found in the autonomic nervous system (ANS) of subjects with spinal cord injuries (SCI). OBJECTIVE: To explore the acute effect of tDCS on ANS indexed by Heart Rate Variability (HRV) in individuals with SCI and analyze whether this effect depends on the gender, degree, level and time of injury...
2017: Restorative Neurology and Neuroscience
https://www.readbyqxmd.com/read/28157112/dual-mode-noninvasive-brain-stimulation-over-the-bilateral-primary-motor-cortices-in-stroke-patients
#6
Jae Yong Cho, Ahee Lee, Min Su Kim, Eunhee Park, Won Hyuk Chang, Yong-Il Shin, Yun-Hee Kim
BACKGROUND: Noninvasive brain stimulation (NBS) using repetitive transcranial magnetic stimulation (rTMS) or transcranial direct current stimulation (tDCS) has recently been adopted for modulating motor function in stroke patients. OBJECTIVE: We investigated the effect of simultaneous dual-mode stimulation using rTMS and tDCS over the bilateral primary motor cortices (M1) to assess its efficacy as compared to single stimulation using rTMS for the recovery of motor function in subacute stroke patients...
2017: Restorative Neurology and Neuroscience
https://www.readbyqxmd.com/read/28157111/waist-up-protection-for-blind-individuals-using-the-eyecane-as-a-primary-and-secondary-mobility-aid
#7
Galit Buchs, Noa Simon, Shachar Maidenbaum, Amir Amedi
BACKGROUND: One of the most stirring statistics in relation to the mobility of blind individuals is the high rate of upper body injuries, even when using the white-cane. OBJECTIVE: We here addressed a rehabilitation- oriented challenge of providing a reliable tool for blind people to avoid waist-up obstacles, namely one of the impediments to their successful mobility using currently available methods (e.g., white-cane). METHODS: We used the EyeCane, a device we developed which translates distances from several angles to haptic and auditory cues in an intuitive and unobtrusive manner, serving both as a primary and secondary mobility aid...
2017: Restorative Neurology and Neuroscience
https://www.readbyqxmd.com/read/28157110/connexin40-correlates-with-oxidative-stress-in-brains-of-traumatic-brain-injury-rats
#8
Wei Chen, Yijun Guo, Wenjin Yang, Ping Zheng, Jinsong Zeng, Wusong Tong
BACKGROUND: Oxidative stress is an important factor in the pathophysiologic changes after traumatic brain injury (TBI). Connexin43 (Cx43) was reported to contribute to cerebral damage. However, the impacts of Cx40 have not been investigated in detail. OBJECTIVE: In the present study, we hypothesized that Cx40 was involved in oxidative stress-induced brain injury after TBI. METHODS: The controlled cortical impact (CCI) model was introduced to Wistar rats as a TBI model...
2017: Restorative Neurology and Neuroscience
https://www.readbyqxmd.com/read/28059806/intrahemispheric-theta-rhythm-desynchronization-impairs-working-memory
#9
Ivan Alekseichuk, Stefanie Corinna Pabel, Andrea Antal, Walter Paulus
BACKGROUND: There is a growing interest in large-scale connectivity as one of the crucial factors in working memory. Correlative evidence has revealed the anatomical and electrophysiological players in the working memory network, but understanding of the effective role of their connectivity remains elusive. OBJECTIVE: In this double-blind, placebo-controlled study we aimed to identify the causal role of theta phase connectivity in visual-spatial working memory. METHODS: The frontoparietal network was over- or de-synchronized in the anterior-posterior direction by multi-electrode, 6 Hz transcranial alternating current stimulation (tACS)...
2017: Restorative Neurology and Neuroscience
https://www.readbyqxmd.com/read/28059805/crocin-protects-against-cerebral-ischemia-induced-damage-in-aged-rats-through-maintaining-the-integrity-of-blood-brain-barrier
#10
Xuan Zhang, Zhixin Fan, Ting Jin
BACKGROUND: A clear relationship exists between oxidative stress and disruption of blood-brain barrier (BBB) during cerebral ischemia, in which aging may exacerbate the extent of leakage. Here, we aim to examine the potential role of a water-soluble carotenoid-based antioxidant crocin on BBB damage in aged rats following cerebral ischemia. METHODS: A two months oral administration of crocin was applied to 24-month-old rats followed by an induction of brain ischemia by middle cerebral artery occlusion (MCAO)...
2017: Restorative Neurology and Neuroscience
https://www.readbyqxmd.com/read/28059803/whole-body-vibration-wbv-following-spinal-cord-injury-sci-in-rats-timing-of-intervention
#11
Marilena Manthou, Diana Saad Yousif Abdulla, Stoyan Pavlov Pavlov, Ramona Jansen, Habib Bendella, Klaus Nohroudi, Gregor Stein, Carolin Meyer, Ozlem Ozsoy, Umut Ozsoy, Yasemin Behram Kandemir, Levent Sarikcioglu, Oliver Semler, Eckhard Schoenau, Sarah Dunlop, Doychin Nikolov Angelov
BACKGROUND: Following spinal cord injury (SCI), exercise training provides a wide range of benefits and promotes activity-dependent synaptic plasticity. Whole body vibration (WBV) in SCI patients improves walking and spasticity as well as bone and muscle mass. However, little is known about the effects of timing or frequency of intervention. OBJECTIVE: To determine which WBV-onset improves locomotor and bladder functions and influences synaptic plasticity beneficially...
2017: Restorative Neurology and Neuroscience
https://www.readbyqxmd.com/read/28059802/recent-progress-in-translational-research-on-neurovascular-and-neurodegenerative-disorders
#12
Hans-Ulrich Demuth, Rick M Dijkhuizen, Tracy D Farr, Mathias Gelderblom, Karen Horsburgh, Costantino Iadecola, Damian D Mcleod, Dominik Michalski, Tim H Murphy, Josune Orbe, Willem M Otte, Gabor C Petzold, Nikolaus Plesnila, Georg Reiser, Klaus G Reymann, Maria A Rueger, Dorothee Saur, Sean I Savitz, Stephan Schilling, Neil J Spratt, Renée J Turner, Raghu Vemuganti, Denis Vivien, Manuel Yepes, Marietta Zille, Johannes Boltze
The already established and widely used intravenous application of recombinant tissue plasminogen activator as a re-opening strategy for acute vessel occlusion in ischemic stroke was recently added by mechanical thrombectomy, representing a fundamental progress in evidence-based medicine to improve the patient's outcome. This has been paralleled by a swift increase in our understanding of pathomechanisms underlying many neurovascular diseases and most prevalent forms of dementia. Taken together, these current advances offer the potential to overcome almost two decades of marginally successful translational research on stroke and dementia, thereby spurring the entire field of translational neuroscience...
2017: Restorative Neurology and Neuroscience
https://www.readbyqxmd.com/read/28059801/repeated-anodal-transcranial-direct-current-stimulation-induces-neural-plasticity-associated-gene-expression-in-the-rat-cortex-and-hippocampus
#13
Min Sun Kim, Ho Koo, Sang Who Han, Walter Paulus, Michael A Nitsche, Yun-Hee Kim, Jin A Yoon, Yong-Il Shin
BACKGROUND: Anodal transcranial direct current stimulation (A-tDCS) induces a long-lasting increase in cortical excitability that can increase gene transcription in the brain. OBJECTIVE: The purpose of this study was to evaluate the expression of genes related to activity-dependent neuronal plasticity in the sensorimotor cortex and hippocampus of young Sprague-Dawley rats following A-tDCS. METHODS: We applied A-tDCS over the right sensorimotor cortex epicranially with a circular electrode (3 mm diameter) at 250 μA for 20 min per day for 7 consecutive days...
2017: Restorative Neurology and Neuroscience
https://www.readbyqxmd.com/read/28059799/self-awareness-rehabilitation-after-traumatic-brain-injury-a-pilot-study-to%C3%A2-compare-two-group-therapies
#14
Jessica Rigon, Roberto Burro, Cecilia Guariglia, Manuela Maini, Dario Marin, Paola Ciurli, Umberto Bivona, Rita Formisano
BACKGROUND AND PURPOSE: Deficits of self-awareness (SA) are very common after severe acquired brain injury (sABI), especially in traumatic brain injury (TBI), playing an important role in the efficacy of the rehabilitation process. This pilot study provides information regarding two structured group therapies for disorders of SA. METHODS: Nine patients with severe TBI were consecutively recruited and randomly assigned to one SA group therapy programme, according either to the model proposed by Ben-Yishay & Lakin (1989) (B&L Group), or by Sohlberg & Mateer (1989) (S&M Group)...
2017: Restorative Neurology and Neuroscience
https://www.readbyqxmd.com/read/27858723/safety-and-improvement-of-movement-function-after-stroke-with-atomoxetine-a%C3%A2-pilot-randomized-trial
#15
Andrea Ward, Cheryl Carrico, Elizabeth Powell, Philip M Westgate, Laurie Nichols, Anne Fleischer, Lumy Sawaki
BACKGROUND: Intensive, task-oriented motor training has been associated with neuroplastic reorganization and improved upper extremity movement function after stroke. However, to optimize such training for people with moderate-to-severe movement impairment, pharmacological modulation of neuroplasticity may be needed as an adjuvant intervention. OBJECTIVE: Evaluate safety, as well as improvement in movement function, associated with motor training paired with a drug to upregulate neuroplasticity after stroke...
2017: Restorative Neurology and Neuroscience
https://www.readbyqxmd.com/read/27768001/diffuse-traumatic-brain-injury-in-the-mouse-induces-a-transient-proliferation-of-oligodendrocyte-progenitor-cells-in-injured-white-matter-tracts
#16
Johanna Flygt, Fredrik Clausen, Niklas Marklund
BACKGROUND: Injury to the white matter may lead to impaired neuronal signaling and is commonly observed following traumatic brain injury (TBI). Although endogenous repair of TBI-induced white matter pathology is limited, oligodendrocyte progenitor cells (OPCs) may be stimulated to proliferate and regenerate functionally myelinating oligodendrocytes. Even though OPCs are present throughout the adult brain, little is known about their proliferative activity following axonal injury caused by TBI...
2017: Restorative Neurology and Neuroscience
https://www.readbyqxmd.com/read/27372514/specific-transfer-effects-following-variable-priority-dual-task-training-in-older-adults
#17
Maxime Lussier, Aurélia Bugaiska, Louis Bherer
PURPOSE: Past divided attention training studies in older adults have suggested that variable priority training (VPT) tends to show larger improvement than fixed priority training (FPT). However, it remains unclear whether VPT leads to larger transfer effects. METHODS: In this study, eighty-three older adults aged between 55 and 65 received five 1-hour sessions of VPT, FPT or of an active placebo. VPT and FPT subjects trained on a complex dual-task condition with variable stimulus timings in order to promote more flexible and self-guided strategies with regard to attentional priority devoted to the concurrent tasks...
2017: Restorative Neurology and Neuroscience
https://www.readbyqxmd.com/read/27689547/steroid-antiviral-for-the-treatment-of-bell-s-palsy-double-blind-randomized-clinical-trial
#18
Eman Mohamed Khedr, Reda Badry, Anwer Mohamed Ali, Noha Abo El-Fetoh, Dina Hatem El-Hammady, Abeer Mohamed Ghandour, Ahmed Abdel-Haleem
BACKGROUND: A large number of patients with Bell's palsy fail to recover facial function completely after steroid therapy. Only a few small trials have been conducted to test whether outcomes can be improved by the addition of antiviral therapy. OBJECTIVE: To evaluate the efficacy of treatment with steroid alone versus steroid + antiviral in a group of patients with moderately severe to severe acute Bell's palsy. METHODS: Fifty eligible patients out of a total of 65 with acute onset Bell's palsy were randomized to receive the two treatments...
November 22, 2016: Restorative Neurology and Neuroscience
https://www.readbyqxmd.com/read/27858724/the-effect-of-combined-therapies-on-recovery-after-acquired-brain-injury-systematic-review-of-preclinical-studies-combining-enriched-environment-exercise-or-task-specific-training-with-other-therapies
#19
Hana Malá, Camilla Pihl Rasmussen
BACKGROUND: Acquired brain injuries (ABI) have devastating effects for the affected individual as well as society. Many studies have investigated the effect of different monotherapies. However, functional recovery is typically only partial. One possible strategy to promote a greater degree of recovery is to apply monotherapies in combination with one or more treatments. OBJECTIVE: The objective of this systematic review is to investigate if approaches combining enriched environment (EE), exercise, or task-specific training with other monotherapies, further enhance the degree of recovery after ABI...
November 16, 2016: Restorative Neurology and Neuroscience
https://www.readbyqxmd.com/read/27858722/defective-chromatic-and-achromatic-visual-pathways-in-developmental-dyslexia-cues-for-an-integrated-intervention-programme
#20
Luca Bonfiglio, Tommaso Bocci, Fabrizio Minichilli, Alessandra Crecchi, Davide Barloscio, Donata Maria Spina, Bruno Rossi, Ferdinando Sartucci
PURPOSE: As well as obtaining confirmation of the magnocellular system involvement in Developmental dyslexia (DD); the aim was primarily to search for a possible involvement of the parvocellular system; and, furthermore, to complete the assessment of the visual chromatic axis by also analysing the koniocellular system. METHODS: Visual evoked potentials (VEPs) in response to achromatic stimuli with low luminance contrast and low spatial frequency, and isoluminant red/green and blue/yellow stimuli with high spatial frequency were recorded in 10 dyslexic children and 10 age- and sex-matched, healthy subjects...
November 16, 2016: Restorative Neurology and Neuroscience
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