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Restorative Neurology and Neuroscience

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https://www.readbyqxmd.com/read/27858724/the-effect-of-combined-therapies-on-recovery-after-acquired-brain-injury-systematic-review-of-preclinical-studies-combining-enriched-environment-exercise-or-task-specific-training-with-other-therapies
#1
Hana Malá, Camilla Pihl Rasmussen
BACKGROUND: Acquired brain injuries (ABI) have devastating effects for the affected individual as well as society. Many studies have investigated the effect of different monotherapies. However, functional recovery is typically only partial. One possible strategy to promote a greater degree of recovery is to apply monotherapies in combination with one or more treatments. OBJECTIVE: The objective of this systematic review is to investigate if approaches combining enriched environment (EE), exercise, or task-specific training with other monotherapies, further enhance the degree of recovery after ABI...
November 16, 2016: Restorative Neurology and Neuroscience
https://www.readbyqxmd.com/read/27858723/safety-and-improvement-of-movement-function-after-stroke-with-atomoxetine-a%C3%A2-pilot-randomized-trial
#2
Andrea Ward, Cheryl Carrico, Elizabeth Powell, Philip M Westgate, Laurie Nichols, Anne Fleischer, Lumy Sawaki
BACKGROUND: Intensive, task-oriented motor training has been associated with neuroplastic reorganization and improved upper extremity movement function after stroke. However, to optimize such training for people with moderate-to-severe movement impairment, pharmacological modulation of neuroplasticity may be needed as an adjuvant intervention. OBJECTIVE: Evaluate safety, as well as improvement in movement function, associated with motor training paired with a drug to upregulate neuroplasticity after stroke...
November 16, 2016: Restorative Neurology and Neuroscience
https://www.readbyqxmd.com/read/27858722/defective-chromatic-and-achromatic-visual-pathways-in-developmental-dyslexia-cues-for-an-integrated-intervention-programme
#3
Luca Bonfiglio, Tommaso Bocci, Fabrizio Minichilli, Alessandra Crecchi, Davide Barloscio, Donata Maria Spina, Bruno Rossi, Ferdinando Sartucci
PURPOSE: As well as obtaining confirmation of the magnocellular system involvement in Developmental dyslexia (DD); the aim was primarily to search for a possible involvement of the parvocellular system; and, furthermore, to complete the assessment of the visual chromatic axis by also analysing the koniocellular system. METHODS: Visual evoked potentials (VEPs) in response to achromatic stimuli with low luminance contrast and low spatial frequency, and isoluminant red/green and blue/yellow stimuli with high spatial frequency were recorded in 10 dyslexic children and 10 age- and sex-matched, healthy subjects...
November 16, 2016: Restorative Neurology and Neuroscience
https://www.readbyqxmd.com/read/27858721/axon-guidance-molecule-expression-after-cell-therapy-in-a-mouse-model-of-parkinson-s-disease
#4
Joanna Kalaani, Rochea Joëlle, Eva Hamade, Bassam Badran, Mohamed Jaber, Afsaneh Gaillard, Laetitia Prestoz
BACKGROUND: Cell therapy is a promising approach for Parkinson's disease (PD). Others and we have previously shown that transplantation of ventral mesencephalic fetal cells into substantia nigra (SN) in an animal model of PD enables anatomical and functional repair of the degenerated pathway. However, the molecular basis of this repair is still largely unknown. OBJECTIVE: In this work, we studied the expression of several axon guidance molecules that may be implicated in the repair of the degenerated nigrostriatal pathway...
November 16, 2016: Restorative Neurology and Neuroscience
https://www.readbyqxmd.com/read/27834788/the-role-of-physical-exercise-in-cognitive-recovery-after-traumatic-brain-injury-a%C3%A2-systematic-review
#5
Timothy Morris, Joyce Gomes-Osman, David Costa-Miserachs, Alvaro Pascual-Leone
BACKGROUND: There is a growing body of evidence revealing exercise-induced effects on brain structure and cognitive function across the lifespan. Animal models of traumatic brain injury also suggest exercise is capable of modulating not only the pathophysiological changes following trauma but also the associated cognitive deficits. OBJECTIVE: To evaluate the effect of physical exercise on cognitive impairment following traumatic brain injury in humans. METHODS: A systematic search of the PubMed database was performed using the search terms "cognition" and "executive function, memory or attention", "traumatic brain injury" and "physical exercise"...
November 8, 2016: Restorative Neurology and Neuroscience
https://www.readbyqxmd.com/read/27834787/cocaine-promotes-primary-human-astrocyte-proliferation-via-jnk-dependent-up-regulation-of-cyclin-a2
#6
Chun-Ting Lee, Kristen L Boeshore, Chun Wu, Kevin G Becker, Stacie L Errico, Deborah C Mash, William J Freed
PURPOSE: Astrocytes perform a plethora of important functions in the central nervous system (CNS) and are involved in cocaine-evoked synaptic plasticity. Previously, we showed that while cocaine decreased cyclin A2 expression in primary human neural progenitor cells, it increased cyclin A2 expression in human astrocytes. Since cyclin A2 is an essential regulator of the cell cycle, the aim of the present study is to clarify the effect of cocaine on proliferation of human astrocytes and elucidate the underlying molecular mechanisms...
November 8, 2016: Restorative Neurology and Neuroscience
https://www.readbyqxmd.com/read/27768001/diffuse-traumatic-brain-injury-in-the-mouse-induces-a-transient-proliferation-of-oligodendrocyte-progenitor-cells-in-injured-white-matter-tracts
#7
Johanna Flygt, Fredrik Clausen, Niklas Marklund
BACKGROUND: Injury to the white matter may lead to impaired neuronal signaling and is commonly observed following traumatic brain injury (TBI). Although endogenous repair of TBI-induced white matter pathology is limited, oligodendrocyte progenitor cells (OPCs) may be stimulated to proliferate and regenerate functionally myelinating oligodendrocytes. Even though OPCs are present throughout the adult brain, little is known about their proliferative activity following axonal injury caused by TBI...
October 17, 2016: Restorative Neurology and Neuroscience
https://www.readbyqxmd.com/read/27802245/progesterone-treatment-shows-greater-protection-in-brain-vs-retina-in-a-rat-model%C3%A2-of-middle-cerebral-artery-occlusion-progesterone-receptor-levels-may-play-an-important-role
#8
Rachael S Allen, Iqbal Sayeed, Yuliya Oumarbaeva, Katherine C Morrison, Paul H Choi, Machelle T Pardue, Donald G Stein
BACKGROUND/OBJECTIVE: To determine whether inflammation increases in retina as it does in brain following middle cerebral artery occlusion (MCAO), and whether the neurosteroid progesterone, shown to have protective effects in both retina and brain after MCAO, reduces inflammation in retina as well as brain. METHODS: MCAO rats treated systemically with progesterone or vehicle were compared with shams. Protein levels of cytosolic NF-κB, nuclear NF-κB, phosphorylated NF-κB, IL-6, TNF-α, CD11b, progesterone receptor A and B, and pregnane X receptor were assessed in retinas and brains at 24 and 48 h using western blots...
October 13, 2016: Restorative Neurology and Neuroscience
https://www.readbyqxmd.com/read/27689551/effects-of-anodal-tdcs-and-occupational-therapy-on-fine-motor-skill-deficits-in-patients-with-chronic-stroke
#9
Nela V Ilić, Emilija Dubljanin-Raspopović, Una Nedeljković, Sanja Tomanović-Vujadinović, Sladjan D Milanović, Ivana Petronić-Marković, Tihomir V Ilić
BACKGROUND: A growing body of evidence supports the effectiveness of using transcranial direct current stimulation (tDCS) in patients with chronic hand motor impairment resulting from stroke. OBJECTIVE: In this study, we investigate and compare the combined effects of anodal tDCS and occupational therapy (OT) to sham stimulation with OT (control) on fine motor skill deficits of chronic stroke patients. METHODS: A total of 26 stroke patients (at ≥ 9 months) were randomly assigned to an active treatment or a control group in a double-blinded, sham-controlled, parallel design study...
September 29, 2016: Restorative Neurology and Neuroscience
https://www.readbyqxmd.com/read/27689550/association-between-genetic-variation-in-the-dopamine-system-and-motor-recovery-after-stroke
#10
Bo-Ram Kim, Hahn Young Kim, Young Il Chun, Yeo-Min Yun, Hyuntae Kim, Dong-Hee Choi, Jongmin Lee
BACKGROUND: The dopamine system plays a key role in motor learning and neuroplasticity. Several studies have studied the efficacy of dopaminergic drugs in enhancing motor recovery after stroke, but the effects are controversial. Although genetic variations in plasticity-related genes influence each individual's capacity for recovery after stroke, limited studies have investigated the effects of polymorphism of dopamine-related genes. OBJECTIVE: We aimed to investigate the association between motor recovery in stroke patients and polymorphisms in the dopamine-related genes catechol-O-methyltransferase (COMT), dopamine receptor D1 (DRD1), DRD2, and DRD3...
September 29, 2016: Restorative Neurology and Neuroscience
https://www.readbyqxmd.com/read/27689549/the-effects-of-combined-repetitive-transcranial-magnetic-stimulation-and-transcranial-direct-current-stimulation-on-motor-function-in-patients-with-stroke
#11
Tae Gun Kwon, Eunhee Park, Chung Kang, Won Hyuk Chang, Yun-Hee Kim
BACKGROUND: Both transcranial magnetic stimulation (rTMS) and transcranial direct current stimulation (tDCS), when provided to stroke patients in combination with motor training, enhance therapeutic efficacy and motor function. However, the majority of previous studies have only examined a single treatment modality. OBJECTIVE: The authors investigated the modulating influence of combination dual-mode brain stimulation upon bihemispheric stimulation with motor training in stroke patients...
September 29, 2016: Restorative Neurology and Neuroscience
https://www.readbyqxmd.com/read/27689548/mental-chronometry-and-mental-rotation-abilities-in-stroke-patients-with-different-degrees-of-sensory-deficit
#12
Joachim Liepert, Imke Büsching, Aida Sehle, Mircea Ariel Schoenfeld
BACKGROUND: Motor imagery is used for treatment of motor deficits after stroke. Clinical observations suggested that motor imagery abilities might be reduced in patients with severe sensory deficits. This study investigated the influence of somatosensory deficits on temporal (mental chronometry, MC) and spatial aspects of motor imagery abilities. METHODS: Stroke patients (n = 70; <6 months after stroke) were subdivided into 3 groups according to their somatosensory functions...
September 29, 2016: Restorative Neurology and Neuroscience
https://www.readbyqxmd.com/read/27689547/steroid-antiviral-for-the-treatment-of-bell-s-palsy-double-blind-randomized-clinical-trial
#13
Eman Mohamed Khedr, Reda Badry, Anwer Mohamed Ali, Noha Abo El-Fetoh, Dina Hatem El-Hammady, Abeer Mohamed Ghandour, Ahmed Abdel-Haleem
BACKGROUND: A large number of patients with Bell's palsy fail to recover facial function completely after steroid therapy. Only a few small trials have been conducted to test whether outcomes can be improved by the addition of antiviral therapy. OBJECTIVE: To evaluate the efficacy of treatment with steroid alone versus steroid + antiviral in a group of patients with moderately severe to severe acute Bell's palsy. METHODS: Fifty eligible patients out of a total of 65 with acute onset Bell's palsy were randomized to receive the two treatments...
September 29, 2016: Restorative Neurology and Neuroscience
https://www.readbyqxmd.com/read/27886015/author-index
#14
(no author information available yet)
No abstract text is available yet for this article.
November 22, 2016: Restorative Neurology and Neuroscience
https://www.readbyqxmd.com/read/27589505/a-new-therapeutic-application-of%C3%A2-brain-machine-interface-bmi-training-followed-by-hybrid-assistive-neuromuscular-dynamic-stimulation-hands-therapy-for%C3%A2-patients-with-severe-hemiparetic-stroke-a-proof-of-concept-study
#15
Michiyuki Kawakami, Toshiyuki Fujiwara, Junichi Ushiba, Atsuko Nishimoto, Kaoru Abe, Kaoru Honaga, Atsuko Nishimura, Katsuhiro Mizuno, Mitsuhiko Kodama, Yoshihisa Masakado, Meigen Liu
BACKGROUND: Hybrid assistive neuromuscular dynamic stimulation (HANDS) therapy improved paretic upper extremity motor function in patients with severe to moderate hemiparesis. We hypothesized that brain machine interface (BMI) training would be able to increase paretic finger muscle activity enough to apply HANDS therapy in patients with severe hemiparesis, whose finger extensor was absent. OBJECTIVE: The aim of this study was to assess the efficacy of BMI training followed by HANDS therapy in patients with severe hemiparesis...
September 21, 2016: Restorative Neurology and Neuroscience
https://www.readbyqxmd.com/read/27589504/subcortical-encoding-of-speech-cues-in%C3%A2-children-with-congenital-blindness
#16
Zahra Jafari, Saeed Malayeri
BACKGROUND: Congenital visual deprivation underlies neural plasticity in different brain areas, and provides an outstanding opportunity to study the neuroplastic capabilities of the brain. OBJECTIVES: The present study aimed to investigate the effect of congenital blindness on subcortical auditory processing using electrophysiological and behavioral assessments in children. METHODS: A total of 47 children aged 8-12 years, including 22 congenitally blind (CB) children and 25 normal-sighted (NS) control, were studied...
September 21, 2016: Restorative Neurology and Neuroscience
https://www.readbyqxmd.com/read/27567760/the-effects-of-mechanical-focal-vibration-on%C3%A2-walking-impairment-in-multiple-sclerosis-patients-a-randomized-double-blinded-vs%C3%A2-placebo-study
#17
Emanuele Spina, Antonio Carotenuto, Maria Gabriella Aceto, Ilaria Cerillo, Francesco Silvestre, Francesco Arace, Paolo Paone, Giuseppe Orefice, Rosa Iodice
BACKGROUND: Multiple Sclerosis is a heterogeneous disorders involving in early stage gait and balance. Together with immunomodulating therapies, rehabilitation had a crucial role in improving motor tasks and quality of life. Between the emerging techniques, Focal Vibrations (FV) could play a role, but they have been used in MS only to reduce muscle tone and fatigue alone or together with botulinum toxin. OBJECTIVE: To assess whether FV is effective on walking impairment in a cohort of MS patients...
September 21, 2016: Restorative Neurology and Neuroscience
https://www.readbyqxmd.com/read/27567759/after-effects-of-anodal-transcranial-direct-current-stimulation-on-the-excitability-of%C3%A2-the%C3%A2-motor-cortex-in-rats
#18
Ho Koo, Min Sun Kim, Sang Who Han, Walter Paulus, Michael A Nitche, Yun-Hee Kim, Hyoung-Ihl Kim, Sung-Hwa Ko, Yong-Il Shin
PURPOSE: Transcranial direct current stimulation (tDCS) is increasingly seen as a useful tool for noninvasive cortical neuromodulation. A number of studies in humans have shown that when tDCS is applied to the motor cortex it can modulate cortical excitability. It is especially interesting to note that when applied with sufficient duration and intensity, tDCS can enable long-lasting neuroplastic effects. However, the mechanism by which tDCS exerts its effects on the cortex is not fully understood...
September 21, 2016: Restorative Neurology and Neuroscience
https://www.readbyqxmd.com/read/27567758/chronic-corticosterone-administration-reduces-dendritic-complexity-in-mature-but%C3%A2-not-young-granule-cells-in-the-rat-dentate-gyrus
#19
Suk-Yu Yau, Ang Li, Jian-Bin Tong, Crystal Bostrom, Brian R Christie, Tatia M C Lee, Kwok-Fai So
BACKGROUND: Our previous work has shown that exposure to the stress hormone corticosterone (40 mg/kg CORT) for two weeks induces dendritic atrophy of pyramidal neurons in the hippocampal CA3 region and behavioral deficits. However, it is unclear whether this treatment also affects the dentate gyrus (DG), a subregion of the hippocampus comprising a heterogeneous population of young and mature neurons. OBJECTIVE: We examined the effect of CORT treatment on the dendritic complexity of mature and young granule cells in the DG...
September 21, 2016: Restorative Neurology and Neuroscience
https://www.readbyqxmd.com/read/27567757/illusion-of-arm-movement-evoked-by-tendon-vibration-in-patients-with-spinal-cord-injury
#20
Gabriele Fusco, Emmanuele Tidoni, Nicola Barone, Claudio Pilati, Salvatore Maria Aglioti
BACKGROUND: Studies in healthy people show that stimulation of muscle spindles through frequency-specific tendon vibration (TV) induces the illusory perception of movement. Following spinal cord injury (SCI), motor and sensory connections between the brain and parts of the body below-the-lesion level are partially or totally impaired. OBJECTIVE: The present investigation is a descriptive study aimed to investigate whether people living with SCI may experience movement illusions comparable to a control group...
September 21, 2016: Restorative Neurology and Neuroscience
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