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European Journal of Cancer

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https://www.readbyqxmd.com/read/27889671/european-journal-of-cancer-s-biennial-report-on-soft-tissue-and-visceral-sarcomas-or-the-rapid-evolution-of-treatment-concepts-in-sarcomas
#1
Jean-Yves Blay, Mehdi Brahmi, Isabelle Ray-Coquard
Soft tissue and visceral sarcoma gather a large group of rare to very rare cancers and locally aggressive connective tissue tumours. Novel concepts on histological and molecular classification, optimal management of patients, systemic adjuvant and neoadjuvant treatment have been emerging in the last 5 years. In the present publication, we review and summarise significant changes which impact on disease management in this group of rare cancers.
November 24, 2016: European Journal of Cancer
https://www.readbyqxmd.com/read/27888679/continuing-rise-in-oropharyngeal-cancer-in-a-high-hpv-prevalence-area-a-danish-population-based-study-from-2011-to-2014
#2
Amanda-Louise Fenger Carlander, Christian Grønhøj Larsen, David Hebbelstrup Jensen, Emilie Garnæs, Katalin Kiss, Luise Andersen, Caroline Holkmann Olsen, Maria Franzmann, Estrid Høgdall, Susanne K Kjær, Bodil Norrild, Lena Specht, Elo Andersen, Thomas van Overeem Hansen, Finn Cilius Nielsen, Christian von Buchwald
BACKGROUND: Human papillomavirus (HPV) is a critical element in the rising incidence of oropharyngeal squamous cell carcinoma (OPSCC), although whether this trend will continue, and the types of HPV responsible, are currently unknown. We previously demonstrated an increased incidence of HPV-related OPSCC in the high HPV prevalence area of Eastern Denmark from 2000 to 2010. Therefore, we investigated if the incidence for OPSCC continued to rise, the association to HPV and putative HPV-types in Eastern Denmark from 2011 to 14...
November 23, 2016: European Journal of Cancer
https://www.readbyqxmd.com/read/27886573/nuclear-transportation-of-exogenous-epidermal-growth-factor-receptor-and-androgen-receptor-via-extracellular-vesicles
#3
Jolene Read, Alistair Ingram, Hassan A Al Saleh, Khrystyna Platko, Kathleen Gabriel, Anil Kapoor, Jehonathan Pinthus, Fadwa Majeed, Talha Qureshi, Khalid Al-Nedawi
Epidermal growth factor receptor (EGFR) plays a central role in the progression of several human malignancies. Although EGFR is a membrane receptor, it undergoes nuclear translocation, where it has a distinct signalling pathway. Herein, we report a novel mechanism by which cancer cells can directly transport EGFR to the nucleus of other cells via extracellular vesicles (EVs). The transported receptor is active and stimulates the nuclear EGFR pathways. Interestingly, the translocation of EGFR via EVs occurs independently of the nuclear localisation sequence that is required for nuclear translocation of endogenous EGFR...
November 22, 2016: European Journal of Cancer
https://www.readbyqxmd.com/read/27883926/application-of-genetically-engineered-salmonella-typhimurium-for-interferon-gamma-induced-therapy-against-melanoma
#4
Wonsuck Yoon, Yoo Chang Park, Jinseok Kim, Yang Seok Chae, Jung Hye Byeon, Sang-Hyun Min, Sungha Park, Young Yoo, Yong Keun Park, Byeong Mo Kim
Salmonella have been experimentally used as anti-cancer agents, because they show selective growth in tumours. In this study, we genetically modified attenuated Salmonella typhimurium to express and secrete interferon-gamma (IFN-γ) as a tumouricidal agent to enhance the therapeutic efficacy of Salmonella. IFN-γ was fused to the N-terminal region (residues 1-160) of SipB (SipB160) for secretion from bacterial cells. Attenuated S. typhimurium expressing recombinant IFN-γ (S. typhimurium (IFN-γ)) invaded the melanoma cells and induced cytotoxicity...
November 21, 2016: European Journal of Cancer
https://www.readbyqxmd.com/read/27870981/healthy-dietary-patterns-and-incidence-of-biliary-tract-and-gallbladder-cancer-in-a-prospective-study-of-women-and-men
#5
Susanna C Larsson, Niclas Håkansson, Alicja Wolk
BACKGROUND: Whether diet influences the risk of biliary tract cancer (BTC) is unknown. We examined the associations of two healthy dietary patterns, including a modified Dietary Approach to Stop Hypertension (mDASH) diet and a modified Mediterranean (mMED) diet, with the incidence of BTC in a population-based prospective study. METHODS: The study population comprised 76,014 Swedish adults who were 45-83 years of age and cancer-free at baseline. The mDASH and mMED diets were calculated from self-reported dietary data collected by a validated food-frequency questionnaire...
November 18, 2016: European Journal of Cancer
https://www.readbyqxmd.com/read/27866097/current-therapy-and-the-evolving-molecular-landscape-of-paediatric-ependymoma
#6
REVIEW
Soumen Khatua, Vijay Ramaswamy, Eric Bouffet
Ependymomas are the third commonest paediatric central nervous system (CNS) tumour, accounting for 6-12% of brain tumours in children. The management of these tumours has seen considerable changes over the last two decades, leading to a significant improvement in outcomes. However, despite advances in neurosurgical, neuroimaging and postoperative adjuvant therapy, management of these tumours remain challenging, and recurrence occurs in over 50% of cases, particularly when complete resection is not achieved prior to conformal radiotherapy...
November 17, 2016: European Journal of Cancer
https://www.readbyqxmd.com/read/27866096/comparative-effectiveness-and-safety-of-thalidomide-and-lenalidomide-in-patients-with-multiple-myeloma-in-the-united-states-of-america-a-population-based-cohort-study
#7
Jing Luo, Joshua J Gagne, Joan Landon, Jerry Avorn, Aaron S Kesselheim
BACKGROUND: The comparative effectiveness of thalidomide and lenalidomide in the treatment of multiple myeloma has not been established. We conducted an observational cohort study of multiple myeloma patients receiving either thalidomide or lenalidomide in routine care in the United States of America to assess their comparative survival and rates of peripheral neuropathy. METHODS: Myeloma patients were identified and followed using administrative claims data from a large national health insurance provider (UnitedHealth)...
November 17, 2016: European Journal of Cancer
https://www.readbyqxmd.com/read/27866095/continuing-egfr-inhibition-beyond-progression-in-advanced-non-small-cell-lung-cancer
#8
REVIEW
Timothy A Yap, Aislinn Macklin-Doherty, Sanjay Popat
The majority of patients with epidermal growth factor receptor (EGFR) mutant non-small cell lung cancer (NSCLC) respond to first-line EGFR tyrosine kinase inhibitors (TKIs), but nearly all inevitably acquire resistance and develop disease progression. Conventional practice would be to switch treatments to second-line therapy. However, continuing TKIs beyond progression is becoming increasingly commonplace in patients with indolent, small volume asymptomatic growth, who may potentially continue to derive ongoing clinical benefit and to avoid a 'withdrawal tumour flare'...
November 17, 2016: European Journal of Cancer
https://www.readbyqxmd.com/read/27866094/-neo-adjuvant-treatment-in-localised-soft-tissue-sarcoma-the-unsolved-affair
#9
REVIEW
Maristella Saponara, Silvia Stacchiotti, Paolo G Casali, Alessandro Gronchi
Soft tissue sarcomas (STS) are rare and heterogeneous tumours. A correct definition of STS is imperative from the very beginning of disease management, to guide the diagnostic and imaging work-up, and help to establish the prognosis on which the therapeutic strategy will be based. Over the last few years, many efforts have been made to identify characteristics that could predict disease behaviour and to enrich the therapeutic armamentarium against the advanced disease, that is still characterised by poor prognosis...
November 17, 2016: European Journal of Cancer
https://www.readbyqxmd.com/read/27855351/targeted-therapy-and-elderly-people-a-review
#10
REVIEW
Amaury Daste, Camille Chakiba, Charlotte Domblides, Marine Gross-Goupil, Amandine Quivy, Alain Ravaud, Pierre Soubeyran
The use of targeted therapy (TT) has radically changed the outcome of various cancers and introduces the era of personalised medicine. Elderly patients (≥65 years) represent the majority of cancer diagnoses and deaths by age group with an increase expected over the next decade. This group of patients is heterogeneous with three categories of patients: fit, vulnerable and frail, with specific treatment for each subgroup. In this review, we assess safety and efficacy of TT in elderly patients, principally from data of pivotal clinical trials with subgroup analysis, but elderly people represented a small percentage of the total number of patients...
November 14, 2016: European Journal of Cancer
https://www.readbyqxmd.com/read/27847222/use-of-maintenance-endocrine-therapy-after-chemotherapy-in-metastatic-breast-cancer
#11
REVIEW
S Sutherland, D Miles, A Makris
BACKGROUND: For women with oestrogen receptor+ metastatic breast cancer (MBC), the options for systemic treatment include endocrine therapy (ET) and chemotherapy. For women whose disease is also HER2+, anti-HER2 therapies are also routinely used either with chemotherapy or less commonly with ET. Where chemotherapy is used as initial therapy, treatment is often discontinued due to cumulative toxicity in the absence of disease progression. In this setting, there is the option of introducing ET with the aim of prolonging response and delaying relapse...
November 12, 2016: European Journal of Cancer
https://www.readbyqxmd.com/read/27838512/a-systematic-review-examining-factors-influencing-health-related-quality-of-life-among-melanoma-cancer-survivors
#12
REVIEW
Jean-Francois Hamel, Madeline Pe, Corneel Coens, Francesca Martinelli, Alexander M M Eggermont, Yvonne Brandberg, Andrew Bottomley
Eighty percent of melanomas are diagnosed at a localised stage, when they are highly curable. Their survival rate induces long follow-up periods, transforming melanoma into a chronic disease and patients' health-related quality of life (HRQoL). Understanding which patient characteristics are associated with poor HRQoL should allow a more personalised management of their HRQoL. Hence, we propose a systematic review for this purpose. Systematic literature searches were performed in three different electronic databases: PubMed, Web of Science and the Cochrane Library...
November 10, 2016: European Journal of Cancer
https://www.readbyqxmd.com/read/27837710/role-of-tumour-free-margin-distance-for-loco-regional-control-in-vulvar-cancer-a-subset-analysis-of-the-arbeitsgemeinschaft-gyn%C3%A3-kologische-onkologie-care-1-multicenter-study
#13
Linn Woelber, Lis-Femke Griebel, Christine Eulenburg, Jalid Sehouli, Julia Jueckstock, Felix Hilpert, Nikolaus de Gregorio, Annette Hasenburg, Atanas Ignatov, Peter Hillemanns, Sophie Fuerst, Hans-Georg Strauss, Klaus H Baumann, Falk C Thiel, Alexander Mustea, Werner Meier, Philipp Harter, Pauline Wimberger, Lars Christian Hanker, Barbara Schmalfeldt, Ulrich Canzler, Tanja Fehm, Alexander Luyten, Martin Hellriegel, Jens Kosse, Christoph Heiss, Peer Hantschmann, Peter Mallmann, Berno Tanner, Jacobus Pfisterer, Barbara Richter, Petra Neuser, Sven Mahner
AIM OF THE STUDY: A tumour-free pathological resection margin of ≥8 mm is considered state-of-the-art. Available evidence is based on heterogeneous cohorts. This study was designed to clarify the relevance of the resection margin for loco-regional control in vulvar cancer. METHODS: AGO-CaRE-1 is a large retrospective study. Patients (n = 1618) with vulvar cancer ≥ FIGO stage IB treated at 29 German gynecologic-cancer-centres 1998-2008 were included. This subgroup analysis focuses on solely surgically treated node-negative patients with complete tumour resection (n = 289)...
November 9, 2016: European Journal of Cancer
https://www.readbyqxmd.com/read/27835821/bevacizumab-versus-anti-epidermal-growth-factor-receptor-in-first-line-metastatic-colorectal-cancer-a-meta-analysis-the-last-building-block
#14
EDITORIAL
Michel Ducreux, Jean-Pierre Pignon
No abstract text is available yet for this article.
December 2016: European Journal of Cancer
https://www.readbyqxmd.com/read/27825697/geriatric-factors-analyses-from-ffcd-2001-02-phase-iii-study-of-first-line-chemotherapy-for-elderly-metastatic-colorectal-cancer-patients
#15
Thomas Aparicio, Dany Gargot, Laurent Teillet, Emilie Maillard, Dominique Genet, Jacques Cretin, Christophe Locher, Olivier Bouché, Gilles Breysacher, Jean-François Seitz, Mohamed Gasmi, Laetitia Stefani, Mohamed Ramdani, Thierry Lecomte, Dominique Auby, Roger Faroux, Jean-Baptiste Bachet, Céline Lepère, Faiza Khemissa, Iradj Sobhani, Olivier Boulat, Emmanuel Mitry, Jean-Louis Jouve
AIM: Several predictors of metastatic colorectal cancer (mCRC) outcomes have been described. Specific geriatric characteristics could be of interest to determine prognosis. METHOD: Elderly patients (75+) with previously untreated mCRC were randomly assigned to receive infusional 5-fluorouracil-based chemotherapy, either alone (FU) or in combination with irinotecan (IRI). Geriatric evaluations were included as an optional procedure. The predictive value of geriatric parameters was determined for the objective response rate (ORR), progression-free survival (PFS) and overall survival (OS)...
November 5, 2016: European Journal of Cancer
https://www.readbyqxmd.com/read/27825560/systemic-treatment-of-advanced-papillary-renal-cell-carcinoma-where-next
#16
EDITORIAL
Samra Turajlic, James Larkin
No abstract text is available yet for this article.
November 4, 2016: European Journal of Cancer
https://www.readbyqxmd.com/read/27821323/combination-of-shear-wave-elastography-and-ki-67-index-as-a-novel-predictive-modality-for-the-pathological-response-to-neoadjuvant-chemotherapy-in-patients-with-invasive-breast-cancer
#17
Yan Ma, Shuo Zhang, Li Zang, Jing Li, Jianyi Li, Ye Kang, Weidong Ren
PURPOSE: This study evaluated shear wave elastography (SWE) and SWE combined with the Ki-67 index as novel predictive modalities for the pathological response of invasive breast cancer to neoadjuvant chemotherapy (NAC). METHODS: The prospective study recruited 66 eligible patients from July 2014 to November 2015. Tumour stiffness, which corresponds with tumour progression and invasiveness, was assessed by quantitative SWE 1 d before biopsy (time point t0, elasticity E0), 1 d before next NAC cycle (t1-t5, E1-E5), and 1 d before surgery (t6, E6)...
November 4, 2016: European Journal of Cancer
https://www.readbyqxmd.com/read/27821322/determinants-of-ototoxicity-in-451-platinum-treated-dutch-survivors-of-childhood-cancer-a-dcog-late-effects-study
#18
Eva Clemens, Andrica C de Vries, Saskia F Pluijm, Antoinette Am Zehnhoff-Dinnesen, Wim J Tissing, Jacqueline J Loonen, Eline van Dulmen-den Broeder, Dorine Bresters, Birgitta Versluys, Leontien C Kremer, Heleen J van der Pal, Martine van Grotel, Marry M van den Heuvel-Eibrink
Platinum-containing chemotherapeutics are efficacious for a variety of pediatric malignancies, nevertheless these drugs can induce ototoxicity. However, ototoxicity data on large cohorts of childhood cancer survivors (CCSs) who received platinum agents, but not cranial irradiation are scarce. Therefore, we have studied the frequency and determinants of ototoxicity in a cross-sectional multicenter CCS cohort, including the role of co-medication since it has been suggested that these play a role in ototoxicity...
November 4, 2016: European Journal of Cancer
https://www.readbyqxmd.com/read/27821321/unemployment-risk-at-2-and-4-years-following-colorectal-cancer-diagnosis-a-population-based-study
#19
Yakir Rottenberg, Navah Z Ratzon, Miri Cohen, Ayala Hubert, Beatrice Uziely, Angela G E M de Boer
BACKGROUND: About half of colorectal patients are diagnosed less than 65 years of age and they have a relatively high cure rate. However, little is known about their employment and related risk factors. The aim of the current study was to clarify the association between colorectal cancer (CRC) and subsequent risk of being unemployed. METHODS: A historical prospective cohort study included baseline socio-demographic measurements of age, sex, ethnicity, residential socio-economic position and education from the 1995 Israeli National Census, cancer incidence between 2000 and 2007 and employment data between 1998 and 2011...
November 4, 2016: European Journal of Cancer
https://www.readbyqxmd.com/read/27821320/significant-increase-of-synchronous-disease-in-first-line-metastatic-colorectal-cancer-trials-results-of-a-systematic-review
#20
REVIEW
Kaitlyn K H Goey, Jorine 't Lam-Boer, Johannes H W de Wilt, Cornelis J A Punt, Martijn G H van Oijen, Miriam Koopman
BACKGROUND: Although synchronous and metachronous metastases are considered as separate entities of metastatic colorectal cancer (mCRC) with different outcomes, its proportion is reported infrequently. We compared inclusion rates and survival of synchronous versus metachronous mCRC in different types of studies investigating initial systemic therapy or surgical treatment of mCRC. METHODS: We searched PubMed and EMBASE (January 2004 - February 2016) for mCRC studies investigating first-line systemic therapy or surgical treatment of mCRC including information on synchronous versus metachronous metastases...
November 4, 2016: European Journal of Cancer
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