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European Journal of Cancer

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https://www.readbyqxmd.com/read/28923573/neoadjuvant-buparlisib-plus-trastuzumab-and-paclitaxel-for-women-with-her2-primary-breast-cancer-a-randomised-double-blind-placebo-controlled-phase-ii-trial-neophoebe
#1
Sibylle Loibl, Lorena de la Pena, Valentina Nekljudova, Dimitrios Zardavas, Stefan Michiels, Carsten Denkert, Mahdi Rezai, Begoña Bermejo, Michael Untch, Soo Chin Lee, Sabine Turri, Patrick Urban, Sherko Kümmel, Guenther Steger, Andrea Gombos, Michael Lux, Martine J Piccart, Gunter Von Minckwitz, José Baselga, Sherene Loi
AIM: The Neoadjuvant PI3K inhibition in HER2 OverExpressing Breast cancEr (NeoPHOEBE) trial evaluated the efficacy and safety of buparlisib, a pan-phosphatidylinositol 3-kinase (PI3K) inhibitor, plus trastuzumab and paclitaxel as neoadjuvant treatment for human epidermal growth factor receptor-2 positive (HER2+) breast cancer. METHODS: NeoPHOEBE was a neoadjuvant, phase II, randomised, double-blind study. Women with HER2+ breast cancer were randomised within two independent cohorts by PIK3CA mutation status and, in each cohort stratified by oestrogen receptor (ER) status to receive buparlisib or placebo plus trastuzumab (first 6 weeks) followed by buparlisib or placebo with trastuzumab and paclitaxel...
September 15, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28918186/health-related-quality-of-life-in-melanoma-patients-impact-of-melanoma-related-limb-lymphoedema
#2
Caroline A Gjorup, Mogens Groenvold, Helle W Hendel, Karin Dahlstroem, Krzysztof T Drzewiecki, Tobias W Klausen, Lisbet R Hölmich
AIM: To explore health-related quality of life (HRQoL) in recurrence-free melanoma patients, with a focus on the association between melanoma-related limb lymphoedema and HRQoL. METHODS: HRQoL was evaluated using the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-C30), the breast cancer module (EORTC QLQ-BR23) subscales body image and future perspective, the Functional Assessment for Cancer Therapy-General subscale social/family well-being and the Hospital Anxiety and Depression Scale...
September 14, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28918185/isolated-limb-perfusion-for-locally-advanced-angiosarcoma-in-extremities-a-multi-centre-study
#3
E A Huis In 't Veld, D J Grünhagen, C Verhoef, H G Smith, A C J van Akkooi, R Jones, F van Coevorden, A J Hayes, W J van Houdt
BACKGROUND: Angiosarcomas are rare and aggressive soft-tissue sarcomas. The only potential curative treatment is complete surgical excision. This study reports the outcome of isolated limb perfusion (ILP) with high-dose melphalan and tumour necrosis factor α for locally advanced angiosarcoma. MATERIAL AND METHODS: All patients who underwent an ILP for angiosarcomas between 1991 and 2016 in three tertiary referral centres were identified from prospectively maintained databases...
September 14, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28917814/late-occurring-nivolumab-induced-cryptogenic-organising-pneumonia-mimicking-lung-progression-in-a-patient-with-metastatic-non-small-cell-lung-cancer
#4
LETTER
Linda Mahjoubi, Anas Gazzah, Aurélien Marabelle, François Le Roy Ladurie, Olivier Lambotte, Caroline Caramella, Julien Adam, Benjamin Besse, Jean-Charles Soria
No abstract text is available yet for this article.
September 13, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28898766/radiation-dose-to-heart-base-linked-with-poorer-survival-in-lung-cancer-patients
#5
Alan McWilliam, Jason Kennedy, Clare Hodgson, Eliana Vasquez Osorio, Corinne Faivre-Finn, Marcel van Herk
BACKGROUND: Advances in radiotherapy (RT) have allowed an increased proportion of lung cancer patients to be treated curatively. High doses delivered to critical thoracic organs can result in excess mortality with tolerance doses poorly defined. This work presents a novel method of identifying anatomical dose-sensitive regions within the thorax. METHODS: A high-resolution, normal-tissue dosimetric analysis was performed to identify regions in the heart that correlate with poorer survival...
September 9, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28892778/an-increase-in-bag-1-by-pd-l1-confers-resistance-to-tyrosine-kinase-inhibitor-in-non-small-cell-lung-cancer-via-persistent-activation-of-erk-signalling
#6
Po-Lin Lin, Tzu-Chin Wu, De-Wei Wu, Lee Wang, Chi-Yi Chen, Huei Lee
High programmed cell death 1 ligand 1 (PD-L1) expression in tumour tissues was associated with poor outcomes in non-small cell lung cancer (NSCLC) due to evasion of tumour immune surveillance. However, the role of PD-L1 in tumour invasion and resistance to tyrosine kinase inhibitor (TKI) treatments is not fully understood. Here, we provide evidence to support the involvement of PD-L1 expression in the invasiveness and TKI resistance in NSCLC cells by increased Bcl-2-associated athanogene-1 (BAG-1) expression...
September 8, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28892777/adherence-to-the-world-cancer-research-fund-american-institute-for-cancer-research-recommendations-and-colorectal-cancer-risk
#7
Federica Turati, Francesca Bravi, Matteo Di Maso, Cristina Bosetti, Jerry Polesel, Diego Serraino, Michela Dalmartello, Attilio Giacosa, Maurizio Montella, Alessandra Tavani, Eva Negri, Carlo La Vecchia
BACKGROUND: The World Cancer Research Fund (WCRF) and the American Institute for Cancer Research (AICR) released in 2007 eight recommendations for cancer prevention on body fatness, diet and physical activity. Our aim is to evaluate the relation between adherence to these recommendations and colorectal cancer (CRC) risk. METHODS: We pooled data from two Italian case-control studies including overall 2419 patients with CRC and 4723 controls. Adherence to the WCRF/AICR guidelines was summarised through a score incorporating seven of the WCRF/AICR recommendations, with higher scores indicating higher adherence to the guidelines...
September 8, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28892776/clinical-trial-simulations-in-paediatric-oncology-a%C3%A2-feasibility-study-from-the-innovative-therapies-for-children-with-cancer-consortium
#8
Julie M Janssen, C Michel Zwaan, Jan H M Schellens, Jos H Beijnen, Alwin D R Huitema
INTRODUCTION: Paediatric dose-finding studies are challenging to perform due to ethical reasons, the limited number of available patients and restricted number of blood samples. In certain cases, the adult pharmacokinetic (PK) exposure can be used as target for dose finding in paediatrics. The aim of this study was to investigate the performance of a paediatric phase I dose-finding clinical trial in silico. METHODS: Using an adult pharmacokinetic model, clinical trial simulations were performed to determine the power of a proposed clinical trial design...
September 8, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28892775/challenges-and-perspectives-in-the-immunotherapy-of-hodgkin-lymphoma
#9
REVIEW
Jean-Marie Michot, Julien Lazarovici, David Ghez, Alina Danu, Christophe Fermé, Amélie Bigorgne, Vincent Ribrag, Aurélien Marabelle, Sandrine Aspeslagh
Hodgkin lymphoma (HL) was one of the first few cancers to be cured first with radiotherapy alone and then with a combination of chemotherapy and radiotherapy. Around 80% of the patients with HL will be cured by first-line therapy. However, the ionising radiation not only produces cytotoxicity but also induces alterations in the microenvironment, and patients often struggle with the long-term consequences of these treatments, such as cardiovascular disorders, lung diseases and secondary malignancies. Hence, it is essential to improve treatments while avoiding delayed side-effects...
September 8, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28888850/ultrasound-based-follow-up-does-not-increase-survival-in-early-stage-melanoma-patients-a-comparative-cohort-study
#10
S Ribero, S Podlipnik, S Osella-Abate, E Sportoletti-Baduel, E Manubens, A Barreiro, V Caliendo, M Chavez-Bourgeois, C Carrera, P Cassoni, J Malvehy, M T Fierro, S Puig
INTRODUCTION: Different protocols have been used to follow up melanoma patients in stage I-II. However, there is no consensus on the complementary tests that should be requested or the appropriate intervals between visits. Our aim is to compare an ultrasound-based follow-up with a clinical follow-up. PATIENTS AND METHODS: Analysis of two prospectively collected cohorts of melanoma patients in stage IB-IIA from two tertiary referral centres in Barcelona (clinical-based follow-up [C-FU]) and Turin (ultrasound-based follow-up [US-FU])...
September 7, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28888849/outcomes-in-non-metastatic-extremity-osteosarcoma-treatment-naive-patients-treated-with-a-novel-non-high-dose-methotrexate-based-dose-dense-combination-chemotherapy-regimen-ogs-12
#11
Jyoti Bajpai, Arun Chandrasekharan, Vikas Talreja, Vijai Simha, M V Chandrakanth, Bharat Rekhi, Sachin Khurana, Arif Khan, Tushar Vora, Jaya Ghosh, Shripad D Banavali, Sudeep Gupta
PURPOSE: High-dose methotrexate (HDMTX)-based regimens are widely used in osteosarcoma. However, mandatory in-patient treatment with complex pharmacokinetic monitoring requirement precludes its use, especially in resource-constrained settings of low- and middle-income countries (LMICs). METHODS: All treatment naive consecutive patients of osteosarcoma were prospectively treated on a novel institutional regimen (named OGS-12) comprising of eight sequential doublets of the following drugs: doxorubicin, cisplatin and ifosfamide in four courses each, given in the neoadjuvant and adjuvant settings...
September 7, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28886476/phase-i-study-of-axitinib-and-everolimus-in-metastatic-solid-tumours-and-extension-to-metastatic-renal-cell-carcinoma-results-of-evax-study
#12
Alain Ravaud, Carlos Gomez-Roca, Marie-Quitterie Picat, Laurence Digue, Christine Chevreau, Anne Gimbert, Emmanuelle Chauzit, Rémi Sitta, François Cornelis, Julien Asselineau, Richard Aziza, Amaury Daste, Cathy Quemener, Jessica Baud, Andréas Bikfalvi, Delphine Pedenon-Périchout, Adelaïde Doussau, Mathieu Molimard, Jean-Pierre Delord
PURPOSE: Anti-angiogenic and mammalian target of rapamycin inhibitors have shown efficacy in solid tumours. Reported combination of both drugs was deemed to be too toxic. Due to a potential favourable safety profile of axitinib (AX), a phase I study combining everolimus (EV) and AX for solid tumours was explored. EXPERIMENTAL DESIGN: Patients (pts) with advanced cancers were enrolled in an escalation phase I study to investigate the safety of the combination. Pharmacokinetic profile and functional vascular imaging were performed...
September 5, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28886475/accuracy-of-screening-women-at-familial-risk-of-breast-cancer-without-a-known-gene-mutation-individual-patient-data-meta-analysis
#13
REVIEW
Xuan-Anh Phi, Nehmat Houssami, Maartje J Hooning, Christopher C Riedl, Martin O Leach, Francesco Sardanelli, Ellen Warner, Isabelle Trop, Sepideh Saadatmand, Madeleine M A Tilanus-Linthorst, Thomas H Helbich, Edwin R van den Heuvel, Harry J de Koning, Inge-Marie Obdeijn, Geertruida H de Bock
INTRODUCTION: Women with a strong family history of breast cancer (BC) and without a known gene mutation have an increased risk of developing BC. We aimed to investigate the accuracy of screening using annual mammography with or without magnetic resonance imaging (MRI) for these women outside the general population screening program. METHODS: An individual patient data (IPD) meta-analysis was conducted using IPD from six prospective screening trials that had included women at increased risk for BC: only women with a strong familial risk for BC and without a known gene mutation were included in this analysis...
September 5, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28881249/cost-effectiveness-analysis-of-pet-ct-guided-management-for-locally-advanced-head-and-neck-cancer
#14
A F Smith, P S Hall, C T Hulme, J A Dunn, C C McConkey, J K Rahman, C McCabe, H Mehanna
BACKGROUND: A recent large United Kingdom (UK) clinical trial demonstrated that positron-emission tomography-computed tomography (PET-CT)-guided administration of neck dissection (ND) in patients with advanced head and neck cancer after primary chemo-radiotherapy treatment produces similar survival outcomes to planned ND (standard care) and is cost-effective over a short-term horizon. Further assessment of long-term outcomes is required to inform a robust adoption decision. Here we present results of a lifetime cost-effectiveness analysis of PET-CT-guided management from a UK secondary care perspective...
September 4, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28881248/value-of-a-short-term-imaging-follow-up-after-a-benign-result-in-a-one-stop-breast-unit-is-it-still-useful
#15
Johanna Daroles, Isabelle Borget, Voichita Suciu, Chafika Mazouni, Suzette Delaloge, Corinne Balleyguier
INTRODUCTION: A short-term radiologic follow-up after a benign breast biopsy or fine needle aspiration (FNA) is recommended in many guidelines. However, the current trend is to reduce imaging investigations, radiation dose and costs. The objectives of this study were to evaluate the cancer detection rate at short-term follow-up and to estimate its cost. METHODS: We retrospectively assessed all consecutive patients referred to our 'one-stop' breast unit between 2004 and 2012, with a benign histological or cytological result and at least one short-term follow-up within 3-12 months after the initial diagnosis...
September 4, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28881247/time-trends-2006-2015-of-quality-indicators-in-eusoma-certified-breast-centres
#16
P A van Dam, M Tomatis, L Marotti, J Heil, R E Mansel, M Rosselli Del Turco, P J van Dam, D Casella, L G Bassani, M Danei, A Denk, D Egle, G Emons, K Friedrichs, N Harbeck, M Kiechle, R Kimmig, U Koehler, S Kuemmel, N Maass, C Mayr, A Prové, C Rageth, L Regolo, F Lorenz-Salehi, D Sarlos, C Singer, C Sohn, G Staelens, C Tinterri, R Audisio, A Ponti
AIM OF THE STUDY: The European Society of Breast Cancer Specialists (EUSOMA) has fostered a voluntary certification process for breast centres to establish minimum standards and ensure specialist multidisciplinary care. Prospectively collected anonymous information on primary breast cancer cases diagnosed and treated in the units is transferred annually to a central EUSOMA data warehouse for continuous monitoring of quality indicators (QIs) to improve quality of care. Units have to comply with the EUSOMA Breast Centre guidelines and are audited by peers...
September 4, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28881246/avoiding-harm-and-supporting-autonomy-are-under-prioritised-in-cancer-screening-policies-and-practices
#17
Lisa Parker, Stacy Carter, Jane Williams, Kristen Pickles, Alexandra Barratt
The ethical principles of avoiding harm and supporting autonomy are relevant to cancer-screening policy. We argue that more attention needs to be given to implementing them. Cancer screening may deliver excessive harms due to low-value or outdated screening programs and from poorly communicated screening options that leave people with heavy burdens of decision-making. Autonomy is inadequately supported due to limited opportunities for people to understand downsides of screening and because of institutional and societal pressures in favour of screening...
September 4, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28877854/letter-to-the-editor-regarding-the-paper-by-loquai-c-et%C3%A2-al-use-of-complementary-and-alternative-medicine-a%C3%A2-multicenter-cross-sectional-study-in-1089-melanoma-patients
#18
LETTER
Elizabeth Fabre, Audrey Thomas-Schoemann, Benoit Blanchet
No abstract text is available yet for this article.
September 3, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28870467/corrigendum-to-advanced-breast-cancer-rates-in-the-epoch-of-service-screening-the-400-000-women-cohort-study-from-italy-eur-j-cancer-75-april-2017-109-116
#19
Donella Puliti, Lauro Bucchi, Silvia Mancini, Eugenio Paci, Susanna Baracco, Cinzia Campari, Debora Canuti, Claudia Cirilli, Natalina Collina, Giovanni Maria Conti, Enza Di Felice, Fabio Falcini, Maria Michiara, Rossella Negri, Alessandra Ravaioli, Priscilla Sassoli De' Bianchi, Monica Serafini, Manuel Zorzi, Adele Caldarella, Luigi Cataliotti, Marco Zappa
No abstract text is available yet for this article.
September 2, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28865261/quality-analysis-of-population-based-information-on-cancer-stage-at-diagnosis-across-europe-with-presentation-of-stage-specific-cancer-survival-estimates-a%C3%A2-eurocare-5-study
#20
Pamela Minicozzi, Kaire Innos, Maria-José Sánchez, Annalisa Trama, Paul M Walsh, Rafael Marcos-Gragera, Nadya Dimitrova, Laura Botta, Otto Visser, Silvia Rossi, Andrea Tavilla, Milena Sant
BACKGROUND: Cancer registries (CRs) are fundamental for estimating cancer burden, evaluating screening and monitoring health service performance. Stage at diagnosis-an essential information item collected by CRs-has been made available, for the first time, by CRs participating in EUROCARE-5. We analysed the quality of this information and estimated stage-specific survival across Europe for CRs with good data quality. DATA AND METHODS: Sixty-two CRs sent stage (as TNM, condensed TNM or extent of disease) for 15 cancers diagnosed in 2000-2007...
September 1, 2017: European Journal of Cancer
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