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Cytokine

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https://www.readbyqxmd.com/read/29137858/human-papillomavirus-e6-and-e7-oncoproteins-affect-the-cell-microenvironment-by-classical-secretion-and-extracellular-vesicles-delivery-of-inflammatory-mediators
#1
Marco Iuliano, Giorgio Mangino, Maria Vincenza Chiantore, Maria Simona Zangrillo, Rosita Accardi, Massimo Tommasino, Gianna Fiorucci, Giovanna Romeo
The connection between chronic inflammation and risk of cancer has been supported by several studies. The development of cancer might be a process driven by the presence of a specific combination of inflammatory mediators, including cytokines, chemokines and enzymes, in the tumor microenvironment. Virus-induced tumors, like HPV-induced Squamous Cell Carcinomas, represent a paradigmatic example of the interplay between inflammation, as integral part of the innate antiviral response, and malignant transformation...
November 11, 2017: Cytokine
https://www.readbyqxmd.com/read/29133026/levels-of-adhesion-molecules-in-peripheral-blood-correlat-with-stages-of-diabetic-retinopathy-and-may-serve-as-bio-markers-for-microvascular-complications
#2
Arnon Blum, Nina Pastukh, Dorina Socea, Hanin Jabaly
BACKGROUND: Proliferative diabetic retinopathy is a devastating complication of diabetes mellitus, developing within 15 years in 50% of patients with type 1 diabetes mellitus (DM) and in 10% of patients with type 2 DM. The correlation between levels of inflammatory markers in the peripheral blood and retinopathy staging has not been studied yet, and the purpose of this prospective study was to find a possible association between inflammation and staging of diabetic retinopathy. METHODS: A prospective (pilot) study that measured level of adhesion molecules in the peripheral blood of 10 healthy subjects and 30 patients with type 2 diabetes mellitus...
November 10, 2017: Cytokine
https://www.readbyqxmd.com/read/29128406/recognition-of-candida-albicans-by-gingival-fibroblasts-the-role-of-tlr2-tlr4-cd14-and-myd88
#3
Claudia Ramos Pinheiro, Ana Lúcia Coelho, Carine Ervolino de Oliveira, Thaís Helena Gasparoto, Gustavo Pompermaier Garlet, João Santana Silva, Carlos Ferreira Santos, Karen Angélica Cavassani, Cory M Hogaboam, Ana Paula Campanelli
Recent evidence indicates that nonprofessional immune cells such as epithelial cells, endothelial cells, and fibroblasts also contribute to innate immunity via secretion of cytokines. Fibroblasts are the principal type of cell found in the periodontal connective tissues and they are involved in the immune response during periodontal disease. The role of fibroblasts in the recognition of pathogens via Toll-like receptors (TLRs) has been established; however, few studies have been conducted concerning the involvement of innate immune receptors in the recognition of Candida albicans by gingival fibroblast...
November 8, 2017: Cytokine
https://www.readbyqxmd.com/read/29128405/systems-cues-governing-il6-signaling-in-leishmaniasis
#4
Bhavnita Soni, Bhaskar Saha, Shailza Singh
IL-6 has been proposed to favor the development of Th2 responses and play an important role in the communication between cells of multicellular organisms. They are involved in the regulation of complex cellular processes such as proliferation, differentiation and act as key player during inflammation and immune response. Th2 cytokines play an immunoregulatory role in early infection. Literature says in mice infected with L. major, IL-6 may promote the development of both Th1 and Th2 responses. IL-4 is also considered to be the signature cytokine of Th-2 response...
November 8, 2017: Cytokine
https://www.readbyqxmd.com/read/29126764/stat5a-and-stat6-gene-expression-levels-in-multiple-sclerosis-patients
#5
Mahsa Hatami, Tayyebali Salmani, Shahram Arsang-Jang, Mir Davood Omrani, Mehrdokht Mazdeh, Soudeh Ghafouri-Fard, Arezou Sayad, Mohammad Taheri
Multiple sclerosis (MS) is a complex inflammatory, autoimmune disease of the central nervous system (CNS). The disease pathogenesis is not well defined yet. Cytokines have an important role in inflammation as characteristic feature of the disease. Janus kinase/signal transducers and activators of transcriptions (JAK/STAT) family promote cytokine-mediated cell activation. Failure in the JAK/STAT signaling pathway is associated with the pathological outcome in MS. In this study, we compared the expression levels of STAT5a and STAT6 genes in the blood of 50 relapsing-remitting MS (RR-MS) patients and 50 healthy controls by Taqman Quantitative Real-Time PCR in patients and healthy control group...
November 7, 2017: Cytokine
https://www.readbyqxmd.com/read/29113741/low-serum-ctrp3-levels-are-associated-with-nonalcoholic-fatty-liver-disease-in-patients-with-type-2-diabetes-mellitus
#6
Junxia Zhang, Bilin Zhang, Yangyang Cheng, Jinxiu Xu
Nonalcoholic fatty liver disease (NAFLD) commonly occurs in patients with type 2 diabetes mellitus (T2DM). C1q/TNF-related protein-3 (CTRP3) levels are decreased in type 2 diabetic patients. However, to date, it is unknown whether low CTRP3 level are correlated with the incidence of NAFLD. The aim of this study was to observe this association in Chinese patients with T2DM. Overall, 175 newly diagnosed T2DM were recruited in this study. The subjects were divided into NAFLD group (n=93) and control group (n=82)...
November 4, 2017: Cytokine
https://www.readbyqxmd.com/read/29108796/multifunctional-neuroprotective-effect-of-withanone-a-compound-from-withania-somnifera-roots-in-alleviating-cognitive-dysfunction
#7
Anjali Pandey, Sarang Bani, Prabhu Dutt, Naresh Kumar Satti, Krishan Avtar Suri, Ghulam Nabi Qazi
Alzheimer's disease (AD) is a chronic disorder that slowly worsens and impairs the person's memory, learning, reasoning, judgment, communication and familiar tasks with loss of orientation. AD is characterized clinically by cognitive deficit and pathologically by the deposition of β amyloid plaques, neurofibrillary tangles, associated with degeneration of the cholinergic forebrain. Withanone (WS-2), a compound isolated from root extract of Withania somnifera at doses administered orally/day to wistar rats for duration of 21 days showed significant improvement in the cognitive skill by inhibiting amyloid β-42 and attenuated the elevated levels of pro-inflammatory cytokines like TNF alpha, IL-1 beta, IL-6, MCP-1, Nitric oxide, lipid peroxidation and both β- and γ- secretase enzymatic activity...
November 3, 2017: Cytokine
https://www.readbyqxmd.com/read/29108795/severity-of-copd-and-its-relationship-with-il-10
#8
Bruna S A Silva, Fábio S Lira, Dionei Ramos, Juliana S Uzeloto, Fabrício Eduardo Rossi, Ana Paula C F Freire, Rebeca N Silva, Iara B Trevisan, Luis Alberto Gobbo, Ercy M C Ramos
BACKGROUND: The present study was designed to compare inflammatory and metabolic responses according to severity of airflow among patients with COPD and to verify the relationship between pulmonary function, body composition, metabolic and inflammatory profile. METHODS: Fifty-one patients with mild to very severe COPD were recruited and divided according lung function in Mild-moderate (GOLD 1-2) n= 21; Severe (GOLD 3) n=25 and Very severe (GOLD 4) n=5. Patients were submitted to assessments of lung function (spirometry), functional exercise capacity (6-min walk test), body composition (Octopolar bioelectrical impedance), metabolic profile (glucose, triglycerides, total cholesterol, HDL-cholesterol and albumin (colorimetric assay)) and inflammatory profile (cytokines: IL-6, IL-10, TNF-α and IL-15 (ELISA))...
November 3, 2017: Cytokine
https://www.readbyqxmd.com/read/29103823/multiple-sclerosis-genetics-results-from-meta-analyses-of-candidate-gene-association-studies
#9
REVIEW
Kalthoum Tizaoui
As a complex disease, multiple sclerosis (MS) susceptibility implicates many genetic and environmental factors. Usually, individual genetic association studies have several limitations, and results are specific to the population of study. The Meta-analysis approach has been proposed to resolve these limitations and to increase the power of statistical analyses. In this review, we summarize results from meta-analyses of candidate genes of MS. Using the keywords: multiple sclerosis, genetic polymorphism and meta-analysis, we searched electronic databases (PubMed, Embase and Web of Sciences) for published meta-analyses until May 2017...
November 2, 2017: Cytokine
https://www.readbyqxmd.com/read/29103822/ziprasidone-a-second-generation-antipsychotic-drug-triggers-a-macrophage-inflammatory-response-in-vitro
#10
Thiago Duarte, Fernanda Barbisan, Pedro Antônio Schmidt do Prado-Lima, Verônica Farina Azzolin, Ivo Emílio da Cruz Jung, Marta Maria Medeiros Frescura Duarte, Cibele Ferreira Teixeira, Moises Henrique Mastella, Ivana Beatrice Mânica da Cruz
Antipsychotic drugs are used to treat schizophrenia and other psychiatric disorders. However, most of these drugs present side effects causing obesity and other serious metabolic alterations that correlate with grade of chronic inflammation. In contrast, ziprasidone's (ZIP) metabolic side effects are attenuated relative to those of other antipsychotic drugs, but some reports suggest that this drug could cause allergic, hypersensitive reactions in susceptible patients. At present, the mechanism of ZIP's effect on peripheral inflammatory metabolism is not well characterized...
November 2, 2017: Cytokine
https://www.readbyqxmd.com/read/29103821/the-impact-of-cytokine-responses-in-the-intra-and-extracellular-signaling-network-of-a-traumatic-injury
#11
Alice A Han, Holly N Currie, Matthew S Loos, Giovanni Scardoni, Julie V Miller, Nicole Prince, Julia A Mouch, Jonathan W Boyd
Investigations of cellular responses involved in injury and repair processes have generated valuable information contributing to the advancement of wound healing and treatments. Intra- and extracellular regulators of healing mechanisms, such as cytokines, signaling proteins, and growth factors, have been described to possess significant roles in facilitating optimal recovery. This study explored a collection of 30 spatiotemporal responses comprised of cytokines (IL-1α, IL-1ß, IL-2, IL-6, TNF-α, MIP-1α), intracellular proteins (Akt, c-Jun, CREB, ERK1/2, JNK, MEK1, p38, p53, p90RSK), phosphorylated proteins (p-Akt, p-c-Jun, p-CREB, p-ERK1/2, p-GSK-3α/ß, p-HSP27, p-IκBα, p-JNK, p-MEK1, p-p38, p-p70S6K, p-p90RSK, p-STAT2, p-STAT3), and a protease (Caspase-3), measured in skeletal muscle tissue following a traumatic injury (rodent Gustilo IIIB fracture)...
November 2, 2017: Cytokine
https://www.readbyqxmd.com/read/29102683/meeting-summary-2nd-aegean-conference-on-cytokine-signaling-in-cancer
#12
REVIEW
Subburaj Ilangumaran, Bryan R G Williams, Dhan V Kalvakolanu
Cytokines and chemokines are intricately connected to cancer initiation, progression and metastasis as well as to innate and adaptive host defense mechanisms against transformed cells. The Aegean Conference on Cytokine Signaling in Cancer (ACCSC) aims to bring together researchers in this highly targeted area of cancer research in a lovely and relaxing Greek-Mediterranean backdrop to discuss latest developments. Being small in size with about one hundred participants, this conference fosters scientific and social interactions among established and emerging scientists in clinical and basic research in diverse fields of oncology, biochemistry, biophysics, genetics and immunology...
November 1, 2017: Cytokine
https://www.readbyqxmd.com/read/29089178/effect-of-anticoagulants-on-162-circulating-immune-related-proteins-in-healthy-subjects
#13
Rianne C Scholman, Barbara Giovannone, Sanne Hiddingh, Jenny M Meerding, Beatriz Malvar Fernandez, Mariska E A van Dijk, Mariëlle J Tempelman, Berent J Prakken, Wilco de Jager
Diagnosis of complex disease and response to treatment is often associated with multiple indicators, both clinical and laboratorial. With the use of biomarkers, various mechanisms have been unraveled which can lead to better and faster diagnosis, predicting and monitoring of response to treatment and new drug development. With the introduction of multiplex technology for immunoassays and the growing awareness of the role of immune-monitoring during new therapeutic interventions it is now possible to test large numbers of soluble mediators in small sample volumes...
October 28, 2017: Cytokine
https://www.readbyqxmd.com/read/29111087/angiogenic-factor-screening-in-women-with-mild-preeclampsia-new-and-significant-proteins-in-plasma
#14
Karol Charkiewicz, Elwira Jasinska, Joanna Goscik, Ewa Koc-Zorawska, Marcin Zorawski, Pawel Kuc, Grzegorz Raba, Tomasz Kluz, Jaroslaw Kalinka, Agata Sakowicz, Piotr Laudanski
INTRODUCTION: The aim of this study was to analyse a panel of 60 angiogenic factors (pro-angiogenic and antiangiogenic) in the plasma of women with mild preeclampsia. MATERIALS AND METHODS: We recruited 21 women between 25 and 40 weeks gestation with diagnosed mild preeclampsia into the study group and 27 healthy women with uncomplicated pregnancies of corresponding gestational age to that of the study to the control group. We used a quantitative protein macroarray method that allowed for analysis of 60 angiogenic proteins per sample simultaneously...
October 27, 2017: Cytokine
https://www.readbyqxmd.com/read/29111086/role-of-interleukin-17-in-tgf-%C3%AE-signaling-mediated-renal-interstitial-fibrosis
#15
Bin Sun, Hui Wang, Lu Zhang, Xiaofan Yang, Mingshun Zhang, Xingxing Zhu, Xiaohui Ji, Huijuan Wang
BACKGROUND: Several studies suggest IL-17 is involved in the pathogenesis of organ fibrosis. The exact role of IL-17 in renal interstitial fibrosis has not been fully elucidated. METHODS: We compared the histopathology of renal fibrosis as well as profibrotic TGF-β signaling in wild-type (WT) and IL-17 knock-out (IL-17(-/-)) mice using UUO as the disease model. To find out the possible mechanisms involved in the exacerbated renal fibrosis happened to IL-17(-/-) mice, we analyzed the pattern of ECM synthesis by different fibroblasts cultured with IL-17 and associated signaling mediators...
October 27, 2017: Cytokine
https://www.readbyqxmd.com/read/29111085/il-37-and-leprosy-a-novel-cytokine-involved-in-the-host-response-to-mycobacterium-leprae-infection
#16
Jorge Rodrigues de Sousa, Renata Lima Prudente, Leonidas Braga Dias Junior, Francisca Regina Oliveira Carneiro, Mirian Nacagami Sotto, Juarez Antonio Simões Quaresma
Leprosy is a chronic infectious granulomatous disease caused by Mycobacterium leprae, in which the clinical outcome depends on the pattern of the host immune response. Because it is a spectral disease, leprosy is a good model for studying the immunology of the pathogen-host relationship. Although previous studies have characterized the participation of cytokine profiles such as Th1, Th2, Th7, Treg, Th9, and Th22 responses in leprosy, the role of new cytokines such as IL-37 have not yet been described for the spectral model of the disease...
October 27, 2017: Cytokine
https://www.readbyqxmd.com/read/29102166/association-between-physical-activity-and-the-expression-of-mediators-of-inflammation-in-normal-breast-tissue-among-premenopausal-and-postmenopausal-women
#17
Mirette Hanna, Isabelle Dumas, Michèle Orain, Simon Jacob, Bernard Têtu, Caroline Diorio
Physical activity is associated with decreased breast cancer risk. The underlying biological mechanisms could include the reduction of the local inflammation in the breast tissue. We conducted a cross-sectional study to assess the association between the physical activity and the protein expression levels of eleven mediators of inflammation in normal breast tissue of 164 women having breast cancer. Information on total physical activity (household, occupational and recreational) performed during a one-year period was collected using a questionnaire...
October 26, 2017: Cytokine
https://www.readbyqxmd.com/read/29102165/effect-of-pregabalin-and-diclofenac-on-tactile-allodynia-mechanical-hyperalgesia-and-pro-inflammatory-cytokine-levels-il-6-il-1%C3%AE-induced-by-chronic-constriction-injury-of-the-infraorbital-nerve-in-rats
#18
Junad Khan, Noma Noboru, Yoshiki Imamura, Eli Eliav
The present study evaluated the effects of systemic pregabalin (PG) and diclofenac (Dic) on neuropathic orofacial pain induced by chronic constriction injury (CCI) of the infraorbital nerve (ION) and on the pro-inflammatory cytokines levels in the affected nerve. Fifty-four rats underwent left infra orbital nerve CCI, and 7 days after the procedure as the pain developed, the rats were randomly assigned to one of the treatment groups: PG 300, 30 or 10 mg/kg, Dic 10, 5 or 1 mg/kg or saline group (Sal) (n/group = 8)...
October 25, 2017: Cytokine
https://www.readbyqxmd.com/read/29102164/soy-isoflavone-genistein-attenuates-lipopolysaccharide-induced-cognitive-impairments-in-the-rat-via-exerting-anti-oxidative-and-anti-inflammatory-effects
#19
Seyed-Mohamad-Sadegh Mirahmadi, Alireza Shahmohammadi, Ali-Mohammad Rousta, Mohammad-Reza Azadi, Javad Fahanik-Babaei, Tourandokht Baluchnejadmojarad, Mehrdad Roghani
Systemic inflammation during infectious disorders usually accompanies chronic complications including cognitive dysfunction. Neuroinflammation and cognitive deficit are also observed in some debilitating neurological disorders like Alzheimer's and Parkinson's diseases. Genistein is a soy isoflavone with multiple beneficial effects including anti-inflammatory, anti-oxidative, and protective properties. In this research study, the effect of genistein in prevention of lipopolysaccharide (LPS)-induced cognitive dysfunction was investigated...
October 25, 2017: Cytokine
https://www.readbyqxmd.com/read/29074034/colony-stimulating-factors-csfs-complex-roles-in-atherosclerosis
#20
Aarushi Singhal, Manikandan Subramanian
Colony stimulating factors (CSFs) play a central role in the development and functional maturation of immune cells besides having pleiotropic effects on cells of the vascular wall. The production of CSFs is induced by multiple atherogenic and inflammatory stimuli and their expression levels are often correlated positively with advanced atherosclerotic plaques and adverse cardiovascular events in humans suggesting that CSFs play a critical role in the pathophysiology of atherosclerosis progression. Interestingly, recombinant CSFs as well as anti-CSFs are being increasingly used for diverse clinical indications...
October 24, 2017: Cytokine
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