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Cytokine

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https://www.readbyqxmd.com/read/28628890/interleukin-6-induced-activation-of-a-non-selective-outward-cation-conductance-in-human-cardiac-fibroblasts
#1
Vadim Mitrokhin, Viktor Kazanski, Vladimir Kalsin, Mitko Mladenov, Andre Kamkin
BACKGROUND: It has been demonstrated that cardiac fibroblasts of the human heart have several myocyte-like features, induced by inflammation. OBJECTIVES: This study analyzed the changes of the expressed currents in the basal condition and in the presence of interleukin-6 in cultured human cardiac fibroblasts. METHODS: Human cardiac fibroblasts were cultured as monolayers from earlier passages (2-4). Whole-cell voltage clamp experiments were performed on single culture human cardiac fibroblasts...
June 16, 2017: Cytokine
https://www.readbyqxmd.com/read/28628889/the-innate-immune-response-to-lower-respiratory-tract-e-coli-infection-and-the-role-of-the-ccl2-ccr2-axis-in-neonatal-mice
#2
Sharon A McGrath-Morrow, Roland Ndeh, Joseph M Collaco, Amy K Poupore, Dustin Dikeman, Qiong Zhong, Benjamin D Singer, Franco D'Alessio, Alan Scott
Neonates have greater morbidity/mortality from lower respiratory tract infections (LRTI) compared to older children. Lack of conditioning of the pulmonary immune system due to limited environmental exposures and/or infectious challenges likely contributes to the increase susceptibility in the neonate. In this study, we sought to gain insights into the nature and dynamics of the neonatal pulmonary immune response to LRTI using a murine model. METHODS: Wildtype (WT) and Ccr2(-/-) C57BL/6 neonatal and juvenile mice received E...
June 16, 2017: Cytokine
https://www.readbyqxmd.com/read/28625874/negative-regulation-of-the-rlh-signaling-by-the-e3-ubiquitin-ligase-rnf114
#3
Boren Lin, Qi Ke, Haiying Li, Nichole S Pheifer, David C Velliquette, Douglas W Leaman
The retinoic acid-inducible gene-I (RIG-I)-like helicases (RLH)s are cytoplasmic pattern recognition receptors expressed in both immune and non-immune cells that are essential for detection of intracellular RNA products, primarily of viral origin. Upon binding to viral RNA, RLHs interact with mitochondrial antiviral signaling protein (MAVS) to activate interferon (IFN)-mediated antiviral responses. The RLH/MAVS signaling pathway is regulated by ubiquitination/deubiquitination, in which several ubiquitin-editing proteins play critical roles...
June 15, 2017: Cytokine
https://www.readbyqxmd.com/read/28609751/aneurysmal-subarachnoid-hemorrhage-lead-to-systemic-upregulation-of-il-23-il-17-inflammatory-axis
#4
Shafqat Rasul Chaudhry, Erdem Güresir, Hartmut Vatter, Thomas M Kinfe, Dirk Dietrich, Alf Lamprecht, Sajjad Muhammad
IL-23 and IL-17 are pro-inflammatory cytokines. IL-23 is secreted by activated macrophages and dendritic cells, while IL-17 by Th17 cells. Serum IL-23 and IL-17 are known to be elevated in numerous inflammatory diseases including neurodegenerative diseases. The role of serum IL-23 and IL-17 in aneurysmal subarachnoid hemorrhage (aSAH) has still not been investigated. The present work investigates the serum IL-23 and IL-17 levels and their association with post hemorrhagic complications and clinical outcome in patients with aSAH...
June 10, 2017: Cytokine
https://www.readbyqxmd.com/read/28609750/association-of-plasma-cd40l-with-acute-chest-syndrome-in-sickle-cell-anemia
#5
Vanessa Tonin Garrido, Laura Sonzogni, Siana Nkya Mtatiro, Fernando F Costa, Nicola Conran, Swee Lay Thein
Platelet activation and platelet-derived cytokines contribute to the vascular inflammation and increased thrombotic activity known to occur in patients with sickle cell anemia (SCA). CD40 ligand (CD40L), a platelet-associated pro-inflammatory molecule that promotes endothelial cell activation, is elevated in the circulation of SCA patients. We sought to evaluate the association of CD40L and inflammation with sickle-related clinical complications and laboratory variables in SCA patients. Soluble CD40L, thrombospondin (TSP)-1 and tumor necrosis factor (TNF)-α were determined in the platelet-poor plasma of healthy individuals and steady-state SCA patients by ELISA...
June 10, 2017: Cytokine
https://www.readbyqxmd.com/read/28599246/ablation-of-il-17-expression-moderates-experimental-autoimmune-myasthenia-gravis-disease-severity
#6
Gabriela Aguilo-Seara, Yanchen Xie, Jarrod Sheehan, Linda L Kusner, Henry J Kaminski
An array of cytokines influences the pathogenesis of early onset myasthenia gravis (MG) and its animal model, experimental autoimmune myasthenia gravis (EAMG). Patients with MG, in particular those with more severe weakness, have elevations of the pro-inflammatory cytokine IL-17 in the blood. We assessed the role of IL-17A in autoimmunity by inducing EAMG in mice with knockout of IL-17 and found a reduction of EAMG severity, but not a complete ablation of disease. The IL-17(ko) mice had no evidence of weakness, low levels of acetylcholine receptor antibodies, and retention of acetylcholine receptor at the neuromuscular junction...
June 6, 2017: Cytokine
https://www.readbyqxmd.com/read/28595117/effect-of-the-anticoagulant-storage-time-and-temperature-of-blood-samples-on-the-concentrations-of-27-multiplex-assayed-cytokines-consequences-for-defining-reference-values-in-healthy-humans
#7
Linda Torrissen Hennø, Elin Storjord, Dorte Christiansen, Grete Bergseth, Judith Krey Ludviksen, Hilde Fure, Svein Barene, Erik Waage-Nielsen, Tom E Mollnes, Ole-Lars Brekke
Cytokines are potentially useful biomarkers of sepsis and other inflammatory conditions. Many cytokines can be released by leukocytes and platelets after sampling. The sampling and processing techniques are consequently critically important to measure the in vivo levels. We therefore examined the effects of four different anticoagulants, EDTA, citrate, lepirudin, heparin compared to serum, on the levels of 27 different cytokines. The effects of storage temperature, freezing and thawing on the plasma cytokines were examined...
June 5, 2017: Cytokine
https://www.readbyqxmd.com/read/28582648/prognostic-factors-of-early-death-in-children-with-hemophagocytic-lymphohistiocytosis
#8
Ze-Bin Luo, Yuan-Yuan Chen, Xiao-Jun Xu, Ning Zhao, Yong-Min Tang
Hemophagocytic lymphohistiocytosis is a rapidly progressing and fatal disease. Early identification of early death for HLH patients based on the laboratory findings at the time of diagnosis could improve the overall survival. A retrospective study was performed on 95 Chinese pediatric patients with HLH. Patients' data including clinical features and laboratory findings at diagnosis were collected. In a multivariate Cox proportional hazard regression model analysis, albumin≤27.75g/L (hazard ratio (HR)=11.82, 95% confidence interval (CI) 2...
June 2, 2017: Cytokine
https://www.readbyqxmd.com/read/28582647/inflammatory-serum-cytokines-and-chemokines-increase-associated-with-the-disease-extent-in-pediatric-langerhans-cell-histiocytosis
#9
Akira Morimoto, Yukiko Oh, Sachie Nakamura, Yoko Shioda, Tomomi Hayase, Toshihiko Imamura, Kazuko Kudo, Shinsaku Imashuku
OBJECTIVE: Langerhans cell histiocytosis (LCH) is characterized by immature dendritic cell proliferation, infiltration of LCH lesions by various inflammatory cells, and a lesional cytokine storm. It is classified into three groups on the basis of disease extent, namely, multisystem with risk-organ involvement (MS+), multisystem without risk-organ involvement (MS-), and single-system (SS) disease. We comprehensively analyzed whether serum levels of cytokines/chemokines reflect the disease extent...
June 2, 2017: Cytokine
https://www.readbyqxmd.com/read/28578295/assessment-of-neutralizing-interleukin-4-effect-on-cd133-gene-expression-in-colon-cancer-cell-line
#10
Amal F Gharib, Sally M Shalaby, Nermin Raafat, Walaa M S Fawzy, Nabila H Abdel Hakim
Colorectal cancer may be maintained by cancer stem-like cells (CSCs) that express the cell surface marker CD133. CSCs (CD133+cells) exhibits greater resistance to the chemotherapy and this resistance may be mediated in part by an autocrine response to IL4. The aim of the study was to assess the effect of anti-IL4 antibody alone or in combination with chemotherapy on the CD133 expression andthe tumor growth. We used Caco cell line in our experiments and the samples were as the following; untreated colorectal cell line, cells treated by chemotherapy, cells treated by anti-IL4 antibody in 3doses (2...
June 1, 2017: Cytokine
https://www.readbyqxmd.com/read/28579221/stat3-in-cancer-a-double-edged-sword
#11
Lidia Avalle, Annalisa Camporeale, Andrea Camperi, Valeria Poli
The transcription factor signal transducer and activator of transcription (STAT) 3 is activated downstream of cytokines, growth factors and oncogenes to mediate their functions under both physiological and pathological conditions. In particular, aberrant/unrestrained STAT3 activity is detected in a wide variety of tumors, driving multiple pro-oncogenic functions. For that, STAT3 is widely considered as an oncogene and is the object of intense translational studies. One of the distinctive features of this factor is however, its ability to elicit different and sometimes contrasting effects under different conditions...
May 31, 2017: Cytokine
https://www.readbyqxmd.com/read/28570933/the-goldilocks-model-of-immune-symbiosis-with-mycobacteria-and-candida-colonizers
#12
REVIEW
Richard T Robinson, Anna R Huppler
Mycobacteria and Candida species include significant human pathogens that can cause localized or disseminated infections. Although these organisms may appear to have little in common, several shared pathways of immune recognition and response are important for both control and infection-related pathology. In this article, we compare and contrast the innate and adaptive components of the immune system that pertain to these infections in humans and animal models. We also explore a relatively new concept in the mycobacterial field: biological commensalism...
May 29, 2017: Cytokine
https://www.readbyqxmd.com/read/28570932/cytokines-as-biomarkers-to-monitoring-the-impact-of-multidrug-therapy-in-immune-response-of-leprosy-patients
#13
Fábio Cassirer-Costa, Nayara I Medeiros, Ana T Chaves, Sandra Lyon, Jordana G A Coelho-Dos-Reis, Atvaldo F Ribeiro-Junior, Rodrigo Correa-Oliveira, Manoel O C Rocha, Juliana A S Gomes
Leprosy or Hansen's disease is a chronic infectious disease of the skin and nerves, caused by the intracellular bacilli Mycobacterium leprae. It is characterized by a spectrum of clinical forms depending on the host's immune response to M. leprae. Patients with tuberculoid (TT) leprosy have strong cell-mediated immunity (CMI) with elimination of the bacilli, whereas patients with lepromatous (LL) leprosy exhibit defective CMI to M. leprae. Despite advances in the understanding of the pathogenesis of leprosy and the development of new therapeutic strategies, there is a need for the identification of biomarkers which be used for early diagnosis and to discrimination between different forms of the disease, as prognostic markers...
May 29, 2017: Cytokine
https://www.readbyqxmd.com/read/28558309/reduced-frequency-of-murine-cytomegalovirus-retinitis-in-c57bl-6-mice-correlates-with-low-levels-of-suppressor-of-cytokine-signaling-socs-1-and-socs3-expression-within-the-eye-during-corticosteroid-induced-immunosuppression
#14
Christine I Alston, Richard D Dix
AIDS-related human cytomegalovirus retinitis remains a leading cause of blindness worldwide. We compared two C57BL/6 mouse models of experimental murine cytomegalovirus (MCMV) retinitis for intraocular expression of suppressors of cytokine signaling (SOCS)1 and SOCS3, host proteins that are inducible negative feedback regulators of cytokine signaling. These mouse models differed in method of immune suppression, one by retrovirus-induced immune suppression (MAIDS) and the other by corticosteroid-induced immune suppression...
May 27, 2017: Cytokine
https://www.readbyqxmd.com/read/28558308/age-predicts-cytokine-kinetics-and-innate-immune-cell-activation-following-intranasal-delivery-of-ifn%C3%AE-and-gm-csf-in-a-mouse-model-of-rsv-infection
#15
Katherine M Eichinger, Erin Resetar, Jacob Orend, Kacey Anderson, Kerry M Empey
Respiratory syncytial virus (RSV) is the leading cause of lower respiratory tract infections in young children and is further associated with increased healthcare utilization and cost of care in the first years of life. Severe RSV disease during infancy has also been linked to the later development of allergic asthma, yet there remains no licensed RSV vaccine or effective treatment. Pre-clinical and clinical studies have shown that disease severity and development of allergic asthma are associated with differences in cytokine production...
May 27, 2017: Cytokine
https://www.readbyqxmd.com/read/28570931/il-17a-causes-depression-like-symptoms-via-nf%C3%AE%C2%BAb-and-p38mapk-signaling-pathways-in-mice-implications-for-psoriasis-associated-depression
#16
Ahmed Nadeem, Sheikh F Ahmad, Naif O Al-Harbi, Ali S Fardan, Ahmed M El-Sherbeeny, Khalid E Ibrahim, Sabry M Attia
Psoriasis has been shown to be associated with an increased prevalence of comorbid major depression. IL-17A plays an important role in both depression and psoriasis. IL-17A has been shown to be elevated in systemic circulation of psoriatic patients. IL-17A released from different immune cells during psoriasis may be responsible for the development of neuropsychiatric symptoms associated with depression. Therefore, this study explored the association of systemic IL-17A with depression. The present study utilized imiquimod model of psoriatic inflammation as well as IL-17A administration in mice to investigate the effect of IL-17A on depression-like behavior...
May 26, 2017: Cytokine
https://www.readbyqxmd.com/read/28554144/muscle-specific-deletion-of-socs3-does-not-reduce-the-anabolic-response-to-leucine-in-a-mouse-model-of-acute-inflammation
#17
M K Caldow, D J Ham, A Chee, J Trieu, T Naim, D I Stapleton, K Swiderski, G S Lynch, R Koopman
Excessive inflammation reduces skeletal muscle protein synthesis leading to wasting and weakness. The janus kinase/signal transducers and activators of transcription-3 (JAK/STAT3) pathway is important for the regulation of inflammatory signaling. As such, suppressor of cytokine signaling-3 (SOCS3), the negative regulator of JAK/STAT signaling, is thought to be important in the control of muscle homeostasis. We hypothesized that muscle-specific deletion of SOCS3 would impair the anabolic response to leucine during an inflammatory insult...
May 25, 2017: Cytokine
https://www.readbyqxmd.com/read/28551592/heterogeneity-of-the-cytokinome-in-undifferentiated-arthritis-progressing-to-rheumatoid-arthritis-and-its-change-in-the-course-of-therapy-move-toward-personalized-medicine
#18
Edyta Brzustewicz, Izabella Bzoma, Agnieszka Daca, Maria Szarecka, Malgorzata Sochocka Bykowska, Jacek M Witkowski, Ewa Bryl
OBJECTIVES: To conduct a comprehensive analysis of cytokine concentrations in sera and mononuclear cell supernatants in order to examine inter- and intra-individual cytokine variations in undifferentiated arthritis progressing to rheumatoid arthritis and healthy control groups. METHODS: Patients with UA (undifferentiated arthritis) developing RA (rheumatoid arthritis) (UA→RA) (n=16) and healthy controls (n=16) were enrolled into the study. UA→RA patients were followed up for six months since the final RA diagnosis...
May 25, 2017: Cytokine
https://www.readbyqxmd.com/read/28527660/how-much-have-we-learnt-about-the-tnf-family-of-cytokines
#19
EDITORIAL
Cong-Qiu Chu
No abstract text is available yet for this article.
May 18, 2017: Cytokine
https://www.readbyqxmd.com/read/28527661/modulation-of-adipocyte-function-by-the-tgf-%C3%AE-family
#20
Yuhang Qiao, Shozo Tomonaga, Masashi Suenaga, Tohru Matsui, Masayuki Funaba
Members of the transforming growth factor-β (TGF-β) family are known to regulate the commitment of mesenchymal stem cells to an adipocyte lineage and the differentiation of preadipocytes to adipocytes. However, the roles of TGF-β family members in mature adipocytes are not known. The present study explored the modulation of cell function in 3T3-L1 adipocytes treated with the TGF-β family members TGF-β1, activin A, activin B, bone morphogenetic protein (BMP) 4, and BMP7. These TGF-β family members modulated the expression of some adipokines; activin A upregulated leptin expression, and activin B downregulated the expression of plasminogen activator inhibitor-1...
May 17, 2017: Cytokine
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