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Cytokine

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https://www.readbyqxmd.com/read/30413290/comparison-of-rt-qpcr-and-nanostring-in-the-measurement-of-blood-interferon-response-for-the-diagnosis-of-type-i-interferonopathies
#1
Rémi Pescarmona, Alexandre Belot, Marine Villard, Laurie Besson, Jonathan Lopez, Isabelle Mosnier, Anne-Laure Mathieu, Christine Lombard, Lorna Garnier, Cécile Frachette, Thierry Walzer, Sébastien Viel
Type I interferonopathies are characterized by an increase of circulating type I interferon (IFN) concentration. Type I interferonopathies refer to rare Mendelian genetic disorders such as Aicardi-Goutières Syndrome (AGS) as well as more frequent and polygenic auto-immune diseases like systemic lupus erythematosus (SLE). Yet, detection of type I IFN in these patients remains challenging as its amount is usually very low in patients' sera. Thus, the detection of interferon-stimulating genes has been proposed as an alternative for the detection of this cytokine but sensitivy, specificity and predictive values of the assay have not been reported so far...
November 6, 2018: Cytokine
https://www.readbyqxmd.com/read/30392846/the-imbalance-of-peripheral-interleukin-18-and-transforming-growth-factor-%C3%AE-1-levels-in-patients-with-cirrhosis-and-esophageal-varices
#2
Agnieszka Swidnicka-Siergiejko, Urszula Wereszczynska-Siemiatkowska, Andrzej Siemiatkowski, Justyna Wasielica-Berger, Jacek Janica, Barbara Mroczko, Andrzej Dabrowski
INTRODUCTION: The presence of esophageal varices in liver cirrhosis indicates clinically significant portal hypertension (PH), that results from structural and dynamic changes in the liver and systemic circulation including the activation of several fibrotic and inflammatory pathways. We assessed if interleukin-18 (IL-18) and transforming growth factor-β1 (TGF-β1) serum levels can be used as PH markers and reflect its severity. MATERIAL AND METHODS: IL-18 and TGF-β1 peripheral blood levels were analyzed in 83 cirrhotic patients with esophageal varices compared to healthy individuals, in relation to MELD and Child-Pugh scores, laboratory and Doppler ultrasound parameters, and non-selective beta-blocker therapy (NSBB)...
November 2, 2018: Cytokine
https://www.readbyqxmd.com/read/30389232/interleukins-as-modulators-of-angiogenesis-and-anti-angiogenesis-in-tumors
#3
REVIEW
Domenico Ribatti
Interleukins (ILs) are secreted by leukocytes and macrophages and are involved in communication amongst leukocytes regulating numerous biological processes and immune responses. This review article analyzes the role played by ILs in the regulation of angiogenesis and anti-angiogenesis in both solid and hematological tumors.
October 30, 2018: Cytokine
https://www.readbyqxmd.com/read/30389231/hepatic-growth-hormone-jak2-stat5-signalling-metabolic-function-non-alcoholic-fatty-liver-disease-and-hepatocellular-carcinoma-progression
#4
Doris Kaltenecker, Madeleine Themanns, Kristina M Mueller, Katrin Spirk, Tobias Suske, Olaf Merkel, Lukas Kenner, Andreia Luís, Andrey Kozlov, Johannes Haybaeck, Mathias Müller, Xiaonan Han, Richard Moriggl
The rising prevalence of obesity came along with an increase in associated metabolic disorders in Western countries. Non-alcoholic fatty liver disease (NAFLD) represents the hepatic manifestation of the metabolic syndrome and is linked to primary stages of liver cancer development. Growth hormone (GH) regulates various vital processes such as energy supply and cellular regeneration. In addition, GH regulates various aspects of liver physiology through activating the Janus kinase (JAK) 2- signal transducer and activator of transcription (STAT) 5 pathway...
October 30, 2018: Cytokine
https://www.readbyqxmd.com/read/30389230/protective-mechanisms-of-resveratrol-derivatives-against-tnf-%C3%AE-induced-inflammatory-responses-in-rat-mesangial-cells
#5
I-Ta Lee, Chwan-Fwu Lin, Yu-Ling Huang, Kowit-Yu Chong, Ming-Fa Hsieh, Tse-Hung Huang, Ching-Yi Cheng
INTRODUCTION: Resveratrol has been reported to alleviate inflammatory responses and oxidative stress in mesangial cells and in several types of renal injury in animal models. Previously, the active resveratrol derivatives from the roots of Vitis thunbergii Sieb. & Zucc. (Vitaceae) were shown to have significant anti-platelet and anti-oxidative activities. However, the anti-inflammatory mechanisms of these resveratrol derivatives in rat mesangial cells (RMCs) have not been clarified fully...
October 30, 2018: Cytokine
https://www.readbyqxmd.com/read/30389229/inflammatory-biomarkers-in-patients-in-simvastatin-treatment-no-effect-of-co-enzyme-q10-supplementation
#6
Maria Hansen, Anja C B Kuhlman, Ronni E Sahl, Bo Kelly, Thomas Morville, Tine L Dohlmann, Karoline M Chrøis, Steen Larsen, Jørn W Helge, Flemming Dela
PURPOSE: Atherosclerosis is a major risk factor for cardiovascular disease (CVD) and is known to be an inflammatory process. Statin therapy decreases both cholesterol and inflammation and is used in primary and secondary prevention of CVD. However, a statin induced decrease of plasma concentrations of the antioxidant coenzyme Q10 (CoQ10), may prevent the patients from reaching their optimal anti-inflammatory potential. Here, we studied the anti-inflammatory effect of Simvastatin therapy and CoQ10 supplementation...
October 30, 2018: Cytokine
https://www.readbyqxmd.com/read/30377055/evaluation-of-gingival-crevicular-fluid-and-peri-implant-crevicular-fluid-levels-of-sclerostin-tweak-rankl-and-opg
#7
Nil Yakar, Guliz N Guncu, Abdullah C Akman, Aslı Pınar, Erdem Karabulut, Rahime M Nohutcu
BACKGROUND: The combination of local and systemic factors play role in the pathogenesis of periodontal and peri-implant diseases. Host-derived enzymes, cytokines and other proinflammatory mediators play an integral role in this destruction. The aim of this study is to evaluate gingival crevicular fluid (GCF) and peri-implant crevicular (PICF) fluid levels of sclerostin, TNF-related weak inducer of apoptosis (TWEAK), receptor activator of nuclear factor kappa-beta ligand (RANKL) and osteoprotegerin OPG in periodontal and peri-implant tissues in disease and health conditions and also to assess the potential for use as biomarkers...
October 27, 2018: Cytokine
https://www.readbyqxmd.com/read/30377054/stat5-deficiency-in-hepatocytes-reduces-diethylnitrosamine-induced-liver-tumorigenesis-in-mice
#8
Doris Kaltenecker, Madeleine Themanns, Kristina M Mueller, Katrin Spirk, Nicole Golob-Schwarzl, Katrin Friedbichler, Lukas Kenner, Johannes Haybaeck, Richard Moriggl
Chronic liver diseases and the development of hepatocellular carcinoma are closely linked and pose a major medical challenge as treatment options are limited. Animal studies have shown that genetic deletion of the signal transducer and activator of transcription (STAT) 5 in liver is associated with higher susceptibility to fatty liver disease, fibrosis and cancer, indicating a protective role of hepatic STAT5 in mouse models of chronic liver disease. To investigate the role of STAT5 in the etiology of liver cancer in more detail, we applied the chemical carcinogen diethylnitrosamine (DEN) to mice harboring a hepatocyte-specific deletion of Stat5 (S5KO)...
October 27, 2018: Cytokine
https://www.readbyqxmd.com/read/30377053/inactivation-of-the-interleukin-22-pathway-in-the-airways-of-cystic-fibrosis-patients
#9
Antoine Guillon, Deborah Brea, Emilie Luczka, Virginie Hervé, Soujoud Hasanat, Camille Thorey, Magdiel Pérez-Cruz, Juliette Hordeaux, Julie Mankikian, Philippe Gosset, Christelle Coraux, Mustapha Si-Tahar
Interleukin (IL)-22 plays a critical role in regulating the maintenance of the mucosal barrier. As airway epithelial regeneration is abnormal in cystic fibrosis (CF), we investigated IL-22 integrity in CF. We first demonstrated, using Il-22-/- mice, that IL-22 is important to prevent lung damage induced by the CF pathogen Pseudomonas aeruginosa. Next, IL-22 receptor was found normally expressed at the airway epithelial surfaces of CF patients. In wound-healing assays, IL-22-treated CF cultures had higher wound-closure rate than controls, suggesting that IL-22 signaling per se could be functional in a CF context...
October 27, 2018: Cytokine
https://www.readbyqxmd.com/read/30360948/human-cardiac-fibroblasts-isolated-from-patients-with-severe-heart-failure-are-immune-competent-cells-mediating-an-inflammatory-response
#10
Joakim Sandstedt, Mikael Sandstedt, Annika Lundqvist, Märta Jansson, Victoria Rotter Sopasakis, Anders Jeppsson, Lillemor Mattsson Hultén
This study was aimed to elucidate the immunoregulatory properties of human cardiac fibroblasts cultured under pro-inflammatory and hypoxic conditions. Human heart tissue for isolating cardiac cells is generally hard to obtain, particularly from all four chambers of the same heart. Since different parts of the heart have different functions and therefore may have different immunoregulatory properties, ability to analyse cells from all chambers allows for a unique and comprehensive investigation. Cells were isolated from all four chambers of the heart from patients undergoing cardiac transplantation surgery due to severe chronic heart failure (CHF) (n = 6)...
October 22, 2018: Cytokine
https://www.readbyqxmd.com/read/30352759/development-of-an-inflammatory-tissue-selective-chimeric-tnf-receptor
#11
Chia-Jung Lee, Chao-Ching Wang, Michael Chen, Kuo-Hsiang Chuang, Tian-Lu Cheng, Ting-Yan Jian, Yun-Ming Wang, Tse-Hung Huang, Kuang-Wen Liao, Shey-Cherng Tzou
BACKGROUND: Inhibiting TNF-α is an effective therapy for inflammatory diseases such as rheumatoid arthritis. However, systemic, nondiscriminatory neutralization of TNF-α is associated with considerable adverse effects. METHODS: Here, we developed a trimeric chimeric TNF receptor by linking an N-terminal mouse Acrp30 trimerization domain and an MMP-2/9 substrate sequence to the mouse extracellular domain of TNF receptor 2 followed by a C-terminal mouse tetranectin coiled-coil domain (mouse Acrp-MMP-TNFR-Tn)...
October 20, 2018: Cytokine
https://www.readbyqxmd.com/read/30352758/prognostic-value-of-fractalkine-cx3cl1-concentration-in-patients-with-acute-myocardial-infarction-treated-with-primary-percutaneous-coronary-intervention
#12
Bing Xu, Yanxia Qian, Yingming Zhao, Zhen Fang, Kangting Tang, Ningtian Zhou, Dianfu Li, Junhong Wang
BACKGROUND: Recent studies demonstrated that fractalkine (FKN) is critically involved in the regulation of inflammation and cardiac function. OBJECTIVE: This study aimed to investigate the prognostic value of circulating FKN in patients with ST-elevated acute myocardial infarction (STEMI) after primary PCI. METHODS: We enrolled ninety consecutive STEMI patients and investigated the association of circulating FKN with myocardial salvage and the occurrence of major adverse cardiac events (MACE) after PCI...
October 20, 2018: Cytokine
https://www.readbyqxmd.com/read/30337217/decreased-serum-levels-of-ctrp12-adipolin-in-patients-with-coronary-artery-disease-in-relation-to-inflammatory-cytokines-and-insulin-resistance
#13
Reza Fadaei, Nariman Moradi, Tooba Kazemi, Elham Chamani, Nahid Azdaki, Sayed Ali Moezibady, Shiva Shahmohamadnejad, Soudabeh Fallah
Coronary artery disease (CAD) is the leading cause of death worldwide. Atherosclerosis as the main underlying mechanism of CAD is associated with inflammation and adipose tissue dysfunction. C1q/TNF-related protein12 (CTRP12) is a newly discovered adipokine which is a paralog of adiponectin. CTRP12 has anti-inflammatory and insulin sensitizing effects. Circulating levels of this adipokine have been reported to be lower in patients with type 2 diabetes and women with polycystic ovarian syndrome. The present study was undertaken for the first time to evaluate serum levels of CTRP12 in CAD patients and its association with anthropometric and biochemical parameters...
October 15, 2018: Cytokine
https://www.readbyqxmd.com/read/30337216/serum-free-amino-acid-levels-in-rheumatoid-arthritis-according-to-therapy-and-physical-disability
#14
Bartosz Urbaniak, Szymon Plewa, Agnieszka Klupczynska, Dorota Sikorska, Włodzimierz Samborski, Zenon J Kokot
BACKGROUND: In presented study the amino acid analysis was performed in serum derived from rheumatoid arthritis patients (RA) according to undertaken therapy and classification of physical disability. The results were compared with previously published data. METHODS: The levels of 31 free amino acids were determined in 50 serum samples derived from RA subjects and 51 controls. The RA patients were divided into two groups according to the therapy (methotrexate/leflunomide, infliximab/adalimumab/etanercept/tocilizumab, prednisolone/NSAID) and classification of physical disability of the patients...
October 15, 2018: Cytokine
https://www.readbyqxmd.com/read/30327173/the-effects-of-aminoguanidine-on-hippocampal-cytokines-amyloid-beta-brain-derived-neurotrophic-factor-memory-and-oxidative-stress-status-in-chronically-lipopolysaccharide-treated-rats
#15
Farimah Beheshti, Milad Hashemzehi, Nona Sabeti, Susan Hashemi Sadr, Mahmoud Hosseini
INTRODUCTION: In the present study, the effects of aminoguanidine (AMG) on hippocampal cytokines, amyloid beta (Aβ), brain-derived neurotrophic factor, oxidative stress status and memory in chronically lipopolysaccharide (LPS) treated rats were investigated. METHODS: The rats were divided into five groups and were treated: (1) Control (Saline), (2) LPS (1 mg/kg), (3-5) LPS- AMG50, LPS-AMG100, and LPS-AMG150 (AMG 50, 100 and 150 mg/kg 30 min before LPS injection)...
October 13, 2018: Cytokine
https://www.readbyqxmd.com/read/30327172/profiles-of-serum-cytokines-and-their-clinical-implications-in-patients-with-peripheral-t-cell-lymphoma
#16
Jun Ho Yi, Kyung Ju Ryu, Young Hyeh Ko, Won Seog Kim, Seok Jin Kim
To better predict the outcomes of patients with peripheral T-cell lymphoma (PTCL), we measured the levels of various cytokines in serum samples from patients with PTCL and analyzed their clinical outcomes. We measured 34 cytokines in samples from 121 PTCL patients (55 PTCL-not otherwise specified (NOS), 44 angioimmunoblastic T-cell lymphoma (AITL), and 22 ALK- anaplastic large cell lymphoma) at diagnosis. Their impact on clinical outcomes, including overall survival and complete response rate, were analyzed with other clinical variables...
October 13, 2018: Cytokine
https://www.readbyqxmd.com/read/30322810/decreased-plasma-neuregulin-4-levels-are-associated-with-peripheral-neuropathy-in-chinese-patients-with-newly-diagnosed-type-2-diabetes-a-cross-sectional-study
#17
Pijun Yan, Yong Xu, Zhihong Zhang, Chenlin Gao, Jianhua Zhu, Hua Li, Qin Wan
Neuregulin-4 (Nrg4) is a novel adipokine associated with obesity, hyperglycemia, insulin resistance, dislipidemia, inflammation, and oxidative stress in mice and humans. However, no report has demonstrated the relationship of circulating Nrg4 with diabetic peripheral neuropathy (DPN). The objective of our study was to investigate the relationship between circulating Nrg4 and DPN in a cross-sectional study. Circulating Nrg4 levels were determined with an enzyme-linked immunosorbent assays kit in 132 newly diagnosed type 2 diabetes mellitus (nT2DM) patients and 41 normal controls (NC group)...
October 12, 2018: Cytokine
https://www.readbyqxmd.com/read/30301599/cervical-cancer-cells-produce-tgf-%C3%AE-1-through-the-cd73-adenosine-pathway-and-maintain-cd73-expression-through-the-autocrine-activity-of-tgf-%C3%AE-1
#18
Rosario García-Rocha, Alberto Monroy-García, Jorge Hernández-Montes, Benny Weiss-Steider, Vianey Gutiérrez-Serrano, María Del Carmen Fuentes-Castañeda, Luis Roberto Ávila-Ibarra, Christian Azucena Don-López, Daniela Berenice Torres-Pineda, María de Lourdes Mora-García
In cancer, the adenosinergic pathway participates in the generation of an immunosuppressive microenvironment and in the promotion of tumor growth through the generation of adenosine (Ado). The present study analyzed the participation of Ado, generated through the functional activity of the cervical cancer (CeCa) pathway in CeCa cells, to induce the expression and secretion of TGF-β1, as well as the participation of this factor to maintain CD73 expression. Ado concentrations greater than 10 μM were necessary to induce an increase of over 50% in the production and expression of TGF-β1 in CeCa tumor cells...
October 6, 2018: Cytokine
https://www.readbyqxmd.com/read/30300856/long-term-outcome-and-necessity-of-liver-transplantation-in-infants-with-biliary-atresia-are-independent-of-cytokine-milieu-in-native-liver-and-serum
#19
Omid Madadi-Sanjani, Joachim F Kuebler, Stephanie Dippel, Anna Gigina, Christine S Falk, Gertrud Vieten, Claus Petersen, Christian Klemann
PURPOSE: Biliary atresia (BA) is a rare disease of unknown pathogenesis in infants characterized by an inflammatory, progressive destruction of the biliary system and deterioration of liver function. The standard treatment for BA is a Kasai-hepatoportoenterostomy (KPE). However, liver transplantation (LTX) becomes necessary in about 50-80% of cases. Therefore, some authors advocate for primary LTX in BA, but this would require early markers to predict which children would benefit from KPE or to show rapid progression to liver cirrhosis (RLC) instead...
October 6, 2018: Cytokine
https://www.readbyqxmd.com/read/30300855/distinct-mechanisms-regulate-il1b-gene-transcription-in-lymphoid-cd4-t-cells-and-monocytes
#20
Sree H Pulugulla, Thomas A Packard, Nicole L K Galloway, Zachary W Grimmett, Gilad Doitsh, Juraj Adamik, Deborah L Galson, Warner C Greene, Philip E Auron
Interleukin 1β is a pro-inflammatory cytokine important for both normal immune responses and chronic inflammatory diseases. The regulation of the 31 kDa proIL-1β precursor coded by the IL1B gene has been extensively studied in myeloid cells, but not in lymphoid-derived CD4 T cells. Surprisingly, we found that some CD4 T cell subsets express higher levels of proIL-1β than unstimulated monocytes, despite relatively low IL1B mRNA levels. We observed a significant increase in IL1B transcription and translation in CD4 T cells upon ex vivo CD3/CD28 activation, and a similar elevation in the CCR5+ effector memory population compared to CCR5- T cells in vivo...
October 6, 2018: Cytokine
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