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Cytokine

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https://www.readbyqxmd.com/read/28094206/hepatocyte-growth-factor-in-physiology-and-infectious-diseases
#1
REVIEW
Ryu Imamura, Kunio Matsumoto
Hepatocyte growth factor (HGF) is a pleiotropic cytokine composed of an α-chain and a β-chain, and these chains contain four kringle domains and a serine protease-like structure, respectively. The receptor for HGF was identified as the c-met proto-oncogene product of transmembrane receptor tyrosine kinase. HGF-induced signaling through the receptor Met provokes dynamic biological responses that support morphogenesis, regeneration, and the survival of various cells and tissues, which includes hepatocytes, renal tubular cells, and neurons...
January 13, 2017: Cytokine
https://www.readbyqxmd.com/read/28092795/moderate-aerobic-exercise-training-for-improving-reproductive-function-in-infertile-patients-a-randomized-controlled-trial
#2
Behzad Hajizadeh Maleki, Bakhtyar Tartibian
This study investigated for the first time the changes in seminal markers of inflammation, oxidative stress status, semen parameters, sperm DNA integrity as well as pregnancy rate following 24weeks of moderate aerobic exercise in infertile patients. A total of 1026 sedentary men (aged 25-40years) attending the infertility clinic with history of more than one year of infertility, were screened and 419 were randomized to either exercise (EX, n=210) or non-exercise (NON-EX, n=209) groups. Exercise training favorably attenuated seminal markers of both inflammation (IL-1β, IL-6, IL-8, and TNF-α) and oxidative stress (ROS, MDA, 8-Isoprostane) as well as enhanced antioxidant defense system (SOD, catalase and TAC) (P<0...
January 13, 2017: Cytokine
https://www.readbyqxmd.com/read/28092794/%C3%AE-defensin-3-modulates-macrophage-activation-and-orientation-during-acute-inflammatory-response-to-porphyromonas-gingivalis-lipopolysaccharide
#3
Jinglu Lyu, Tianying Bian, Bin Chen, Di Cui, Lili Li, Ling Gong, Fuhua Yan
β-defensin 3, a multifunctional antimicrobial peptide, has immuno-regulatory activities. We investigated the modulatory mechanism of human β-defensin 3 (hBD3) on acute inflammatory response resulted from Porphyromonas gingivalis lipopolysaccharide (P.g-LPS), which plays a pro-inflammatory role in periodontal infection and its derived systemic inflammation. P.g-LPS was administrated to mice and murine macrophages alone or along with hBD3. P.g-LPS could lead to acute inflammation as soon as 2h. And it was observed that hBD3 significantly decreased the production of pro-inflammatory biomarkers of in response to P...
January 13, 2017: Cytokine
https://www.readbyqxmd.com/read/28092793/high-dilutions-of-antimony-modulate-cytokines-production-and-macrophage-leishmania-l-amazonensis-interaction-in-vitro
#4
Fabiana Rodrigues de Santana, Luciane C Dalboni, Kátia F Nascimento, Fabiana Toshie Konno, Anuska M Alvares-Saraiva, Michelle S F Correia, Maristela Dutra Correa Bomfim, Renato C V Casarin, Elizabeth C Perez, Maria Anete Lallo, Giovani B Peres, Márcia Dalastra Laurenti, Nilson R Benites, Dorly F Buchi, Leoni Villano Bonamin
BACKGROUND: In previous results mice treated with high dilutions of antimony presented reduction of monocyte migration to the site of infection with increase in B lymphocytes population in the local lymph node. AIMS: To know the mechanisms involved, a series of in vitro studies was done, using co-cultures of macrophages (RAW 264.7) and Leishmania (L.) amazonensis treated with different dilutions of antimony (Antimonium crudum or AC), in different times. METHODOLOGY: Spreading, phagocytosis, the oxidative activity of macrophages, the viability of free promastigotes and the cytokines/chemokines concentration in the supernatant were evaluated...
January 13, 2017: Cytokine
https://www.readbyqxmd.com/read/28088614/ccaat-enhancer-binding-protein-%C3%AE-promotes-pathogenesis-of-eae
#5
Michelle R Simpson-Abelson, Gerard Hernandez-Mir, Erin E Childs, J Agustin Cruz, Amanda C Poholek, Ansuman Chattopadhyay, Sarah L Gaffen, Mandy J McGeachy
The CCAAT/Enhancer Binding Protein β (C/EBPβ) transcription factor is activated by multiple inflammatory stimuli, including IL-17 and LPS, and C/EBPβ itself regulates numerous genes involved in inflammation. However, the role of C/EBPβ in driving autoimmunity is not well understood. Here, we demonstrate that Cebpb(-/-) mice are resistant to EAE. Cebpb(-/-) mice exhibited reduced lymphocyte and APC infiltration into CNS following EAE induction. Furthermore, MOG-induced Th17 cytokine production was impaired in draining LN, indicating defects in Th17 cell priming...
January 12, 2017: Cytokine
https://www.readbyqxmd.com/read/28088613/adipocyte-and-epidermal-fatty-acid-binding-protein-serum-concentrations-in-patients-with-lipodystrophy
#6
Konstanze Miehle, Thomas Ebert, Susan Kralisch, Annett Hoffmann, Jürgen Kratzsch, Haiko Schlögl, Michael Stumvoll, Mathias Fasshauer
OBJECTIVE: Lipodystrophy (LD) syndromes are associated with diabetes mellitus, hypertriglyceridemia, and coronary artery disease. One pathogenetic factor of LD is dysregulation of several adipokines. However, the insulin resistance- and dyslipidemia-promoting adipokines adipocyte (AFABP) and epidermal (EFABP) fatty acid-binding protein have not been investigated in non-HIV-associated LD so far. MATERIAL AND METHODS: We performed a cross-sectional analysis of AFABP and EFABP serum concentrations in 37 LD patients and 37 age-, gender-, and body mass index-matched healthy controls...
January 12, 2017: Cytokine
https://www.readbyqxmd.com/read/28088612/alterations-in-cytokine-gene-expression-profile-in-colon-mucosa-of-inflammatory-bowel-disease-patients-on-different-therapeutic-regimens
#7
Tsvetelina Velikova, Dobroslav Kyurkchiev, Zoya Spassova, Iliya Karakolev, Ekaterina Ivanova-Todorova, Iskra Altankova, Spaska Stanilova
Inflammatory bowel disease (IBD) is assumed to be caused by genetic and environmental factors that interact together in promoting intestinal immune dysregulation where cytokines have validated role. However, the underlying intimate mechanisms in the human IBD involving cytokines still needs to be supplemented especially in the clinical context. The aim of this study was to investigate the expression of some inflammatory and regulatory cytokines (IL-17A, IL-23, IL-6, TGFβ1, and IL-10) as well as of the transcription factor FoxP3 in mucosal samples of IBD and non-IBD patients...
January 12, 2017: Cytokine
https://www.readbyqxmd.com/read/28088611/lactobacillus-paracasei-modulates-lps-induced-inflammatory-cytokine-release-by-monocyte-macrophages-via-the-up-regulation-of-negative-regulators-of-nf-kappab-signaling-in-a-tlr2-dependent-manner
#8
Ke-Yi Sun, Dong-Hua Xu, Chao Xie, Susan Plummer, James Tang, Xiao Fan Yang, Xiao Hui Ji
The application of the probiotic lactobacillus is suggested in the treatment of some inflammatory diseases of intestines due to its potential ability to attenuate inflammation. However, the mechanism is not completely understood. In PBMCs, Lactobacillus paracasei (L. Paracasei) down-regulated the LPS-induced production of TNF-α and IL-6. Using a macrophage-like differentiated THP-1 cell line induced by PMA, we investigated the effect of L. paracasei on the production of pro-inflammatory cytokines by monocyte-macrophages...
January 12, 2017: Cytokine
https://www.readbyqxmd.com/read/28082237/follicular-fluid-cytokine-composition-and-oocyte-quality-of-polycystic-ovary-syndrome-patients-with-metabolic-syndrome-undergoing-in-vitro-fertilization
#9
Zhihong Niu, Yao Ye, Lan Xia, Yun Feng, Aijun Zhang
PURPOSE: To provide insights into the correlation among lipid metabolism, cytokine profiles in the follicular fluid (FF) and embryo quality of women with Polycystic Ovary Syndrome (PCOS) with metabolic syndrome (MS). METHODS: Ninety women undergoing in vitro fertilization (IVF) treatment were recruited, including 60 PCOS patients (PCOS non MS and PCOS MS) and 30 age-matched controls. Individual FF samples were analyzed using the cytometric multiplex immunoassay...
January 9, 2017: Cytokine
https://www.readbyqxmd.com/read/28082236/adenosine-generated-by-ectonucleotidases-modulates-the-host-immune-system-during-visceral-leishmaniasis
#10
Vijayamahantesh, Ajay Amit, Manas R Dikhit, Anshul Mishra, Ashish K Singh, V N R Das, Pradeep Das, Sanjiva Bimal
Adenosine, an endogenous purine nucleoside is one such extracellular signaling molecule whose role in the regulation of anti-inflammatory cytokines and immune pathogenicity in visceral leishmaniasis is indeterminate. Here, we have evaluated the adenosine in the plasma of 20 visceral leishmaniasis (VL) patients during active disease and after successful treatment. We observed the elevated plasma adenosine during active VL disease (26.73±1.95μM) and the level subsides as the treatment progresses and falls to the normal level after successful treatment (4...
January 9, 2017: Cytokine
https://www.readbyqxmd.com/read/28082235/from-stable-disease-to-acute-on-chronic-liver-failure-circulating-cytokines-are-related-to-prognosis-in-different-stages-of-cirrhosis
#11
Josiane Fischer, Telma Erotides Silva, Pedro Eduardo Soares E Silva, Bruno Silveira Colombo, Mariana Costa Silva, Letícia Muraro Wildner, Maria Luiza Bazzo, Elayne Cristina Morais Rateke, Tania Silvia Frode, Silvana Vigil de Mello, Júlia S Rosa, Esther Buzaglo Dantas-Correa, Janaína Luz Narciso-Schiavon, Leonardo Lucca Schiavon
INTRODUCTION: Although both pro- and anti-inflammatory circulating cytokines are known to be elevated in liver cirrhosis, its clinical significance is not completely recognized. Our aim was to evaluate the prognostic significance of circulating cytokines interleukin (IL)-6, IL-17 and IL-10 in different stages of cirrhosis. METHODS: This prospective study included two cohorts: (1) stable cirrhosis attended in the Outpatient Clinic (n=118), and (2) subjects hospitalized for acute decompensation (AD) (n=130)...
January 9, 2017: Cytokine
https://www.readbyqxmd.com/read/28082234/increased-systemic-and-epidermal-levels-of-il-17a-and-il-1%C3%AE-promotes-progression-of-non-segmental-vitiligo
#12
Supriya Bhardwaj, Seema Rani, Niharika Srivastava, Ravinder Kumar, Davinder Parsad
BACKGROUND: Non-segmental vitiligo (NSV) results from autoimmune destruction of melanocytes. The altered levels of various cytokines have been proposed in the pathogenesis of vitiligo. However, the exact immune mechanisms have not yet been fully elucidated. OBJECTIVES: To investigate the role of epidermal and systemic cytokines in active and stable NSV patients. METHODS: Serum levels of inflammatory cytokines were checked in 42 active and 30 stable NSV patients with 30 controls...
January 9, 2017: Cytokine
https://www.readbyqxmd.com/read/28082233/comparison-of-multiplex-platforms-for-cytokine-assessments-and-their-potential-use-for-biomarker-profiling-in-multiple-sclerosis
#13
Arjan Malekzadeh, Harry Twaalfhoven, Nienke J Wijnstok, Joep Killestein, Marinus A Blankenstein, Charlotte E Teunissen
BACKGROUND: The levels of pro and anti-inflammatory cytokines can be altered in different autoimmune pathologies, such as multiple sclerosis (MS). It is likely that cytokines in bodily fluids can provide a good reflection of ongoing disease patho-physiology. In this study we aimed to validate multiplex cytokine platforms and evaluate whether these cytokines are differentially expressed in MS. METHODS: Assay validation for simultaneous quantification of IL-1β, IL-6, IL-8 and TNF-α in serum and CSF were performed using both the Luminex-xMAP (Luminex) and Meso Scale Discovery (MSD) platforms...
January 9, 2017: Cytokine
https://www.readbyqxmd.com/read/28073026/the-role-of-visfatin-in-atherosclerotic-peripheral-arterial-obstructive-disease
#14
Matthaios G Pitoulias, Lemonia Skoura, Apostolos G Pitoulias, Dimitris Chatzidimitriou, Apostolia Margariti, Minas Arsenakis, Georgios A Pitoulias
Visfatin is an adipokine molecule acting as an essential coenzyme in multiple cellular redox reactions. The increased serum levels of Visfatin have been correlated with metabolic syndrome and endothelial homeostasis. In this study we investigate the possible relationship of Visfatin serum levels with the severity and location of atherosclerotic peripheral arterial occlusive disease (PAOD). Study protocol included 45 consecutive PAOD and 20 Control patients with age >55years old. Definition of PAOD was based in Rutherord's classification (RC)...
January 7, 2017: Cytokine
https://www.readbyqxmd.com/read/28064096/high-glucose-induced-lif-suppresses-osteoblast-differentiation-via-regulating-stat3-socs3-signaling
#15
Changlu Liu, Dianming Jiang
High glucose (HG) is conceived to regulate bone metabolism in patients with diabetic mellitus (DM). In the present study, we examined the level of leukemia inhibitory factor (LIF), a pleiotropic cytokine in interleukin (IL)-6 family, in T2DM patients and investigated the regulation by HG on the induction of LIF/signal transducer and activator of transcription 3 (STAT3) signaling. Then we determined the regulation of HG and LIF on the osteoblast differentiation via measuring the ALP activity, matrix mineralization, and the expression of alkaline phosphatase (ALP), Runt-related transcription factor 2 (RUNX2), Osteocalcin (OCN) and osteopontin (OPN) in human osteoblast MG-63 cells...
January 5, 2017: Cytokine
https://www.readbyqxmd.com/read/28063328/long-term-persistence-of-inflammation-in-children-vaccinated-with-salmonella-conjugate-vaccine-is-associated-with-augmented-th9-th17-cytokine
#16
Chinnasamy Balaji, Vijayakumar Kevinkumar, Vivekanandhan Aravindhan
Vaccine induced serum cytokines not only serves as a biomarker of immunity but also serves as a reliable measure of inflammation. Long term persistence of inflammation can lead to metabolic derangement. Towards this end, in the present study, we measured levels of cytokines along with hormones (insulin, leptin and adiponectin) in children who have been vaccinated with Salmonella typhi Vi conjugate vaccine, 30months after vaccination. Vaccinated children showed a unique cytokine profile with suppressed Th1-Th2 and increased Th9-Th17 cytokines indicating immune polarization which was associated with decreased serum adiponectin (but not insulin or leptin) levels...
January 4, 2017: Cytokine
https://www.readbyqxmd.com/read/28063327/serum-levels-of-fibroblast-growth-factor-23-are-elevated-in-patients-with-active-lupus-nephritis
#17
Aline L Resende, Rosilene M Elias, Myles Wolf, Luciene M Dos Reis, Fabiana G Graciolli, Geuza D Santos, Cristiane B Dias, Vanda Jorgetti, Viktoria Woronik, Rosa M A Moysés
BACKGROUND: Fibroblast growth factor 23 (FGF23), a phosphate-regulating hormone is an established cardiovascular risk factor. Recently, FGF23 has been related to inflammation. Lupus is an inflammatory disease, and whether FGF23 is associated with Lupus nephritis (LN) activity is unknown. MATERIALS AND METHODS: We studied 15 pre-menopausal patients with recent LN diagnose (⩽2months) and compared them to 1:1 age-matched healthy control group. We measured serum levels of intact FGF23, interleukin-6 (IL-6), tumor necrosis factor α (TNFα), and urinary levels of monocyte chemotactic protein (MCP1)...
January 4, 2017: Cytokine
https://www.readbyqxmd.com/read/28056393/increased-expression-of-negative-regulators-of-cytokine-signaling-during-chronic-hiv-disease-cause-functionally-exhausted-state-of-dendritic-cells
#18
Meenakshi Sachdeva, Aman Sharma, Sunil K Arora
Mechanisms of functional impairment of dendritic cells (DCs) during chronic HIV-1 infection are not well understood. In order to understand this phenomenon, we aimed to study the expression of negative regulators of cytokine signaling and correlate with DC exhaustion during chronic HIV-1 disease. Monocyte-derived DCs (mo-DCs) from 27 HIV-1 infected patients (CD4+ T-cell counts: 429±44 cells/μL, plasma viral load: Log103.9±1.0copies/ml) and 19 healthy controls (HCs) were stimulated ex vivo with TLR4 agonist, lipopolysaccharide (LPS) for 2days to evaluate their functional fitness...
January 2, 2017: Cytokine
https://www.readbyqxmd.com/read/28043030/potential-gingival-crevicular-fluid-and-serum-biomarkers-by-stage-of-hiv-infection
#19
Jesús Eduardo Elizondo, María Del Refugio Rocha-Pizaña, Ana Cecilia Treviño, Deborah Violant, Mario Moisés Álvarez, Ana María Rivas-Estilla
OBJECTIVE: This study evaluates the potential of gingival crevicular fluid and serum cytokines as HIV stage biomarkers. METHODS: Gingival crevicular fluid (GCF) and serum samples from 78 HIV-positive adult male subjects (cases) and 39 HIV-negative male subjects (controls) from Mexico were examined for 17 cytokines using multiplex ELISA. Participants were divided into five subgroups by HIV stage of infection on age-specific CD4+ T-lymphocyte count and antiretroviral therapy (ART), and further correlated to the cytokine levels...
December 30, 2016: Cytokine
https://www.readbyqxmd.com/read/28043029/cd4-il-21-t-cells-are-correlated-with-regulatory-t-cells-and-il-21-promotes-regulatory-t-cells-survival-during-hiv-infection
#20
Zi-Ning Zhang, Li-Xin Bai, Ya-Jing Fu, Yong-Jun Jiang, Hong Shang
INTRODUCTION: IL-21 enhances T and natural killer cells survival and antiviral functions without promoting T cell activation during HIV infection, which makes it a better adjuvant in anti-HIV immunotherapy. Due to the pleiotropy and redundancy of cytokines, it is vital to have a comprehensive knowledge of the role of IL-21 in the regulation of immune responses. Regulatory T cells (Tregs) play an important role in immune regulation and are a determinant of immune therapeutic efficacy in certain circumstances...
December 30, 2016: Cytokine
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