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Cytokine

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https://www.readbyqxmd.com/read/28325629/towards-integrating-extracellular-matrix-and-immunological-pathways
#1
David F Boyd, Paul G Thomas
The extracellular matrix (ECM) is a complex and dynamic structure made up of an estimated 300 different proteins. The ECM is also a rich source of cytokines and growth factors in addition to numerous bioactive ECM degradation products that influence cell migration, proliferation, and differentiation. The ECM is constantly being remodeled during homeostasis and in a wide range of pathological contexts. Changes in the ECM modulate immune responses, which in turn regulate repair and regeneration of tissues. Here, we review the many components of the ECM, enzymes involved in ECM remodeling, and the signals that feed into immunological pathways in the context of a dynamic ECM...
March 18, 2017: Cytokine
https://www.readbyqxmd.com/read/28324805/limited-role-of-interferon-kappa-ifnk-truncating-mutations-in-common-variable-immunodeficiency
#2
Faranaz Atschekzei, Thilo Dörk, Peter Schürmann, Robert Geffers, Torsten Witte, Reinhold E Schmidt
We used whole exome sequencing to determine the genetic background of CVID in two non-consanguineous German families. We identified IFNK (interferon-kappa) as the only candidate gene that harbored truncating mutations in affected members from both families. One family segregated c.30_31insTGTT, a known frameshift variant, while the other family segregated the novel IFNK mutation p.K199X that creates a premature stop codon. We sequenced the whole coding region of IFNK in a further series of 167 CVID patients and 192 healthy controls...
March 18, 2017: Cytokine
https://www.readbyqxmd.com/read/28324804/high-density-lipoprotein-immunomodulates-the-functional-activities-of-macrophage-and-cytokines-produced-during-ex-vivo-macrophage-cd4-t-cell-crosstalk-at-the-recent-onset-human-type-1-diabetes
#3
Ibtissem Benghalem, Warda Meziane, Zeyneb Hadjidj, Lamia Ysmail-Dahlouk, Ahmed Belamri, Kheira Mouhadjer, Mourad Aribi
BACKGROUND: Both CD4(+) T cells and macrophages are mainly involved in the autoimmune-mediated β-cells destruction in type 1 diabetes (T1D). The aim of this study was to examine the effect of HDL on functional activities of macrophage and its ability to regulate the production of cytokines in autologous mixed macrophage/CD4(+) T cells at the recent-onset human type 1 diabetes. METHODS: Cell samples were isolated from volunteers with recent-onset T1D or healthy controls...
March 16, 2017: Cytokine
https://www.readbyqxmd.com/read/28324803/leishmania-donovani-resistant-to-ambisome-or-miltefosine-exacerbates-cd58-expression-on-nk-cells-and-promotes-trans-membrane-migration-in-association-with-cd2
#4
Pushkar Shivam, Sarita Kumari, Fauzia Jamal, Vikash Kumar, Manish Kumar, Sanjiva Bimal, Shyam Narayan, Vidya Nand Ravi Das, Krishna Pandey, Anil Kumar Gupta, Pradeep Das, Shubhankar Kumar Singh
Visceral leishmaniasis (VL) is a disease that is associated with compromised immunity and drug un-responsiveness as well as with the emergence of drug resistance in Leishmania donovani (Ld). Ld down-modulates cellular immunity by manipulating signaling agents, including a higher expression of the adhesion molecule CD58. The expression of CD58 and CD2 on natural killer (NK) cells facilitates intercellular adhesion and signaling. The influence of drug-resistant Ld on the expression of CD58 and CD2 was addressed in this study...
March 16, 2017: Cytokine
https://www.readbyqxmd.com/read/28288328/case-control-exploratory-study-of-cerebrospinal-fluid-chemokines-cytokines-and-lymphocyte-subsets-in-childhood-tourette-syndrome-with-positive-streptococcal-markers
#5
Michael R Pranzatelli, Elizabeth D Tate, Tyler J Allison
A longstanding question is whether neuroinflammation is present in children symptomatic for Tourette syndrome (TS) with positive streptococcal serology and throat cultures. The objective was to directly test for it using modern hypothesis-driven approaches. Profiling studies for 14 immune cell types (flow cytometry), 7 chemokines/cytokines (ELISA), oligoclonal bands, and other immunoglobulins were performed in this IRB-approved study of 5 children with TS and streptococcal markers compared to data from 26 non-inflammatory pediatric neurological controls...
March 10, 2017: Cytokine
https://www.readbyqxmd.com/read/28288327/parvovirus-b19-infection-modulates-the-levels-of-cytokines-in-the-plasma-of-rheumatoid-arthritis-patients
#6
Milda Naciute, Diana Mieliauskaite, Rita Rugiene, Gabriele Maciunaite, Mykolas Mauricas, Modra Murovska, Irute Girkontaite
BACKGROUND: Parvovirus B19 (B19V) infection is associated with various autoimmune diseases. We investigated the levels of pro-inflammatory (IFNᵧ, TNFα, IL-2, IL-12) and anti-inflammatory (IL-4, IL-10) cytokines in the plasma of B19V DNA positive (B19(+)) and negative (B19(-)) rheumatoid arthritis (RA) patients in comparison with the control group (healthy persons). METHODS: Blood samples were collected from 118 patients with RA and 49 healthy voluntaries. B19V sequence was determined in whole blood and cell-free plasma DNA by nested PCR...
March 10, 2017: Cytokine
https://www.readbyqxmd.com/read/28283223/interferon-regulatory-factor-signaling-in-autoimmune-disease
#7
REVIEW
Bharati Matta, Su Song, Dan Li, Betsy J Barnes
Interferon regulatory factors (IRFs) play critical roles in pathogen-induced innate immune responses and the subsequent induction of adaptive immune response. Dysregulation of IRF signaling is therefore thought to contribute to autoimmune disease pathogenesis. Indeed, numerous murine in vivo studies have documented protection from or enhanced susceptibility to particular autoimmune diseases in Irf-deficient mice. What has been lacking, however, is replication of these in vivo observations in primary immune cells from patients with autoimmune disease...
March 7, 2017: Cytokine
https://www.readbyqxmd.com/read/28283222/correlation-between-serum-interleukin-6-level-and-type-1-diabetes-mellitus-a-systematic-review-and-meta-analysis
#8
Yin-Ling Chen, Yong-Chao Qiao, Yan-Hong Pan, Yan Xu, Yong-Cheng Huang, Yin-Hui Wang, Li-Jun Geng, Hai-Lu Zhao, Xiao-Xi Zhang
OBJECTIVE: This report aimed to explore the association between the change of circulating interleukin-6 (IL-6) in patients and the development of type 1 diabetes mellitus (T1DM). METHODS: Four databases (PubMed, CNKI, WanFang and Civip) were used to search and list all clinical case-control studies about serum IL-6 level in T1DM patients between Jan 1, 2000 and Aug 31, 2016. RESULTS: A total of 20 case-control studies with 1238 T1DM patients and 742 healthy controls were included in this study...
March 7, 2017: Cytokine
https://www.readbyqxmd.com/read/28282610/retinal-pigment-epithelium-secretome-a-diabetic-retinopathy-perspective
#9
REVIEW
Murugeswari Ponnalagu, Murali Subramani, Chaitra Jayadev, Rohit Shetty, Debashish Das
Diabetic retinopathy is a major complication of diabetes mellitus that can lead to retinal vascular abnormalities and visual impairment. While retinal endothelial pathology is well studied, retinal pigment epithelium (RPE) layer modifications and the patho-physiological regulations are not widely understood. The RPE is a highly specialized pigmented layer regulating not only physiological functions such as transport of nutrients, ions, absorption of light, phagocytosis of photoreceptor membranes, but also secretion of a number of cytokines, chemokines, angiogenic and anti-angiogenic factors...
March 7, 2017: Cytokine
https://www.readbyqxmd.com/read/28282548/attenuated-in-vitro-effects-of-ifn-%C3%AE-il-2-and-il-12-on-functional-and-receptor-characteristics-of-peripheral-blood-lymphocytes-in-metastatic-melanoma-patients
#10
Katarina M Mirjačić Martinović, Ana M Vuletić, Nada Lj Babović, Radan R Džodić, Gordana M Konjević, Vladimir B Jurišić
Considering tumor-induced suppression of lymphocytes the aim of this study was to investigate in vitro effects of IFN-α, IL-2, IL-12 and IL-18 as immunomodulating agents on the functional and receptor characteristics of peripheral blood lymphocytes (PBL) in metastatic melanoma (MM) patients compared to healthy controls (HC). In HC IFN-α, IL-2 and IL-12 enhanced mRNA level of perforin by inducing pSTAT-1 and pSTAT-5 signaling molecules. Additionally, the expression of NKG2D activating receptor and its DAP10 signaling molecule was upregulated by IL-2...
March 7, 2017: Cytokine
https://www.readbyqxmd.com/read/28282547/study-of-association-between-interleukin-17-and-interferon-gamma-and-recombinant-human-erythropoietin-dose-in-patients-undergoing-peritoneal-dialysis
#11
Wander Valadares de Oliveira, Roberta Carvalho de Figueiredo, Adriano Sabino de Paula, Sylvia Dias Turani, Marina Souza Silva Velloso, Melina Barros Pinheiro, Karina Braga Gomes, Maria Aparecida Silva Marinho, Sérgio Wyton Lima Pinto, Danyelle Romana Alves Rios
BACKGROUND: A common complication in patients undergoing peritoneal dialysis (PD) is a chronic inflammatory state and anemia that can be treating by recombinant human erythropoietin (rHuEPO). Higher required dose of rHuEPO could be expected in patients with higher cytokine levels. Additionally, it is known that peritoneal inflammation can be correlated with systemic inflammation and this could contribute to the compromised rHuEPO required dose in anemic patients with end stage renal disease (ESRD)...
March 7, 2017: Cytokine
https://www.readbyqxmd.com/read/28279855/anti-therapeutic-antibodies-and-their-clinical-impact-in-patients-treated-with-the-tnf-antagonist-adalimumab
#12
Isabelle Cludts, Francesca Romana Spinelli, Francesca Morello, Jason Hockley, Guido Valesini, Meenu Wadhwa
Patients treated with the TNF antagonist adalimumab develop anti-therapeutic antibodies (ATA), the prevalence of which varies depending on the assay used. Most assays are compromised due to the presence of adalimumab in the clinical samples. Our objective was to develop an antibody assay, applicable for clinical testing, which overcomes the limitation of therapeutic interference and to further determine the relationship between ATA development, adalimumab levels and disease activity in patients with rheumatoid arthritis (RA), psoriatic arthritis (PsA) or ankylosing spondylitis (AS)...
March 6, 2017: Cytokine
https://www.readbyqxmd.com/read/28274776/corrigendum-to-chemokine-cytokine-profiling-after-rituximab-reciprocal-expression-of-bca-1-cxcl13-and-baff-in-childhood-oms-cytokine-53-2011-384-389
#13
Michael R Pranzatelli, Elizabeth D Tate, Anna L Travelstead, Steven J Verhulst
No abstract text is available yet for this article.
March 5, 2017: Cytokine
https://www.readbyqxmd.com/read/28267649/intravitreal-injection-of-anti-interleukin-il-6-antibody-attenuates-experimental-autoimmune-uveitis-in-mice
#14
Jan Tode, Elisabeth Richert, Stefan Koinzer, Alexa Klettner, Ute Pickhinke, Christoph Garbers, Stefan Rose-John, Bernhard Nölle, Johann Roider
PURPOSE: To evaluate the effect of an intravitreally applied anti-IL-6 antibody for the treatment of experimental autoimmune uveitis (EAU). METHODS: EAU was induced in female B10.RIII mice by Inter-Photoreceptor-Binding-Protein (IRBP) in complete Freund's adjuvant, boosted by Pertussis toxin. Single blinded intravitreal injections of anti-IL-6 antibody were applied 5-7days as well as 8-10days (3day interval) after EAU induction into the randomized treatment eye and phosphate buffered saline (PBS) into the fellow control eye...
March 3, 2017: Cytokine
https://www.readbyqxmd.com/read/28267648/expression-of-soluble-cd83-in-plasma-from-early-stage-rheumatoid-arthritis-patients-is-not-modified-by-anti-tnf-%C3%AE-therapy
#15
Anne-Mette Kristensen, Kristian Stengaard-Pedersen, Merete Lund Hetland, Kim Hørslev-Petersen, Peter Junker, Mikkel Østergaard, Per Höllsberg, Bent Deleuran, Malene Hvid
Rheumatoid arthritis (RA) is an autoimmune disease which may lead to severe disabilities due to structural joint damage and extraarticular manifestations The dendritic cell marker CD83 belongs to the immunoglobulin superfamily and has previously been associated with autoimmune diseases. In RA the levels of soluble CD83 (sCD83) are elevated in synovial fluid, however little is known about CD83 expression and regulation in RA. Therefore, we studied how CD83 is expressed in RA and further evaluated the effect of anti-TNF-α therapy hereon...
March 3, 2017: Cytokine
https://www.readbyqxmd.com/read/28260649/higher-serum-interleukin-17a-levels-as-a-potential-biomarker-for-predicting-early-disease-progression-in-patients-with-hepatitis-b-virus-associated-advanced-hepatocellular-carcinoma-treated-with-sorafenib
#16
Hyo Jung Cho, Soon Sun Kim, Ji Sun Nam, Min Jung Oh, Dae Ryong Kang, Jai Keun Kim, Jei Hee Lee, Bohyun Kim, Min Jae Yang, Jae Chul Hwang, Sun Gyo Lim, Sung Jae Shin, Kee Myung Lee, Byung Moo Yoo, Kwang Jae Lee, Sung Won Cho, Jae Youn Cheong
BACKGROUND: Although sorafenib is the only available drug with proven efficacy for patients with advanced hepatocellular carcinoma (HCC), the clinical efficacy of sorafenib is variable and unpredictable. The aim of the current study was to identify potential serum biomarkers predicting cancer progression and overall survival (OS) in patients with hepatitis B virus (HBV)-related advanced HCC treated with sorafenib. METHODS: Thirty-four patients with HBV-related advanced HCC (modified Union for International Cancer Control [UICC] stage IVa or IVb) treated with sorafenib for more than 4weeks were retrospectively enrolled...
March 2, 2017: Cytokine
https://www.readbyqxmd.com/read/28260648/impact-of-freeze-thaw-cycles-on-circulating-inflammation-marker-measurements
#17
Wen-Yi Huang, Troy J Kemp, Ruth M Pfeiffer, Ligia A Pinto, Allan Hildesheim, Mark P Purdue
BACKGROUND: Circulating inflammation markers are being increasingly measured in prospective cohorts to investigate cancer etiology. However, it is unclear how the measurements are affected by the freeze-thaw cycles of the specimens prior to marker analysis. METHODS: We compared concentrations of 45 inflammation markers between paired serum vials of 55 participants in the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial that have undergone one (T1), two (T2), and three (T3) freeze-thaw cycles at the time of assay...
March 2, 2017: Cytokine
https://www.readbyqxmd.com/read/28254558/early-serum-biomarker-networks-in-infants-with-distinct-retinochoroidal-lesion-status-of-congenital-toxoplasmosis
#18
Thádia Evelyn de Araújo, Jordana Grazziela Coelho-Dos-Reis, Samantha Ribeiro Béla, Ana Carolina Aguiar Vasconcelos Carneiro, Anderson Silva Machado, Ludmila Melo Cardoso, Ágata Lopes Ribeiro, Michelle Hallais França Dias, Gláucia Manzan Queiroz Andrade, Daniel Vitor Vasconcelos-Santos, José Nélio Januário, Andréa Teixeira-Carvalho, Ricardo Wagner Almeida Vitor, Eloisa Amália Vieira Ferro, Olindo Assis Martins-Filho
The present study characterized the early changes in the serum chemokines/cytokine signatures and networks in infants with congenital-toxoplasmosis/(TOXO) as compared to non-infected-controls/(NI). TOXO were subgrouped according to the retinochoroidal lesion status as no-lesion/(NL), active-lesion/(ARL), active/cicatricial-lesion/(ACRL) and cicatricial-lesion/(CRL). The results showed that TOXO display prominent chemokine production mediated by IL-8/CXCL8, MIG/CXCL9, IP-10/CXCL10 and RANTES/CCL5. Additionally, TOXO is accompanied by mixed proinflammatory/regulatory cytokine pattern mediated by IL-6, IFN-γ, IL-4, IL-5 and IL-10...
February 28, 2017: Cytokine
https://www.readbyqxmd.com/read/28254560/homeopathic-medicines-cause-th1-predominance-and-induce-spleen-and-megakaryocytes-changes-in-balb-c-mice-infected-with-leishmania-infantum
#19
Ana Paula Bacellar Cajueiro, Ester Puna Goma, Hilton Antônio Mata Dos Santos, Igor Almeida Rodrigues, Helena Keiko Toma, Silvana Marques Araújo, Leoni Villano Bonamin, Nelson Brêtas de Noronha Gomes, Morgana Teixeira Lima Castelo-Branco, Edilma Paraguai de Souza Dias, Alexandre Dos Santos Pyrrho, Carla Holandino
The prevalence of Th1/Th2 response, spleen changes and megakaryocytes were investigated in BALB/c mice (n=138) infected with Leishmania infantum, and treated with Leishmania infantum 30× (10(-30)) biotherapy - BioLi30×. We performed controlled experiments using 8-to-12-week-old mice, infected with 5×10(7)L. infantum promastigotes, divided into eight groups: G1 (healthy), G2 (infected with L. infantum), G3 (BioLi30× pre-treated), G4 (BioLi30× pre/post-treated), G5 (BioLi30× post-treated), G6 (Water 30× post-treated), G7 (Antimonium crudum 30× post-treated) and G8 (Glucantime® post-treated)...
February 27, 2017: Cytokine
https://www.readbyqxmd.com/read/28254559/aberrant-expression-of-interleukin-10-in-rheumatoid-arthritis-relationship-with-il10-haplotypes-and-autoantibodies
#20
J Hernández-Bello, E Oregón-Romero, M Vázquez-Villamar, S García-Arellano, Y Valle, J R Padilla-Gutiérrez, I V Román-Fernández, C A Palafox-Sánchez, G E Martínez-Bonilla, J F Muñoz-Valle
Interleukin 10 (IL-10) is an immunomodulatory cytokinethat plays a central rolein the pathogenesis of autoimmune diseases. Different studies consistently show increased IL-10 serum levels in rheumatoid arthritis (RA) and it appears to be caused by genetic variants. Three polymorphisms situated at positions -1082, -819 and -592 of IL10 gene and its major haplotypes have been associated with regulating IL10 promoter activity. In this study, we evaluated whether IL10 haplotypes are associated with mRNA expression and IL-10 serum levels as well as susceptibility to RA in a Western Mexican population...
February 27, 2017: Cytokine
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