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Cytokine

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https://www.readbyqxmd.com/read/28807497/characterisation-of-the-porcine-cytokines-which-activate-the-cd131%C3%AE-c-common-sub-unit-for-potential-immune-augmentation
#1
G Stephenson, K R Morris, T E O'Neil, M P Bruce, A D G Strom, A G D Bean
Early acting cytokines and growth factors such as those of the CD131 βc subunit, may offer an alternative method to the current use of antibiotics and chemicals such as anthelmintics in maintaining Porcine (Po) health. Thus far, the recombinant Po (rPo) Granulocyte-macrophage colony-stimulating factor (GM-CSF), rPo interleukin-3 (IL-3) and rPo interleukin-5 (IL-5) proteins have been identified and cloned and the biological activity of each cytokine has been confirmed in vitro, however, in vivo immune system regulation and hematopoietic stem cell (HSC) augmentation are regulated by numerous cytokines and cellular signals within the bone marrow (BM) niche...
August 11, 2017: Cytokine
https://www.readbyqxmd.com/read/28807496/cd4-effector-t-cell-differentiation-is-controlled-by-il-15-that-is-expressed-and-presented-in-trans
#2
Adam T Waickman, Davinna L Ligons, SuJin Hwang, Joo-Young Park, Vanja Lazarevic, Noriko Sato, Changwan Hong, Jung-Hyun Park
T cells are both producers and consumers of cytokines, and autocrine cytokine signaling plays a critical role in T cell immunity. IL-15 is a homeostatic cytokine for T cells that also controls inflammatory immune responses. An autocrine role of T cell-derived IL-15, however, remains unclear. Here we examined IL-15 expression and signaling upon effector T cell differentiation in mice, and, surprisingly, found that CD4 T cells did not express IL-15. CD4 T cells lacked Il15 gene reporter activity, did not contain IL-15 transcripts, and did not produce IL-15Rα, the proprietary IL-15 receptor required for IL-15 trans-presentation...
August 11, 2017: Cytokine
https://www.readbyqxmd.com/read/28803697/tumor-necrosis-factor-alpha-gene-polymorphisms-and-haplotypes-in-egyptian-children-with-nephrotic-syndrome
#3
Doaa M Youssef, Amal S El-Shal, Samia Hussein, Khaled Salah, Abd El Rahman E Ahmed
BACKGROUND: Nephrotic syndrome (NS) characterized by complex pathogenesis and clinical course with relapses; and needs novel breakthroughs for decades. Polymorphisms of cytokines genes including tumor necrosis factor alpha (TNF-α)may influence susceptibility to NS as well as different patients' steroid responses. In the current study, we demonstrated the potential roles of TNF-α promoter gene polymorphisms [-238, -308, -863] and haplotypes in susceptibility to childhood NS. Also, elucidating their possible influence on patients' steroid response and serum TNF-α level...
August 10, 2017: Cytokine
https://www.readbyqxmd.com/read/28803696/differential-modulation-of-glial-cell-mediated-neuroinflammation-in-plasmodium-berghei-anka-infection-by-tgf-%C3%AE-and-il-6
#4
Samrat Sarkar, Tarun Keswani, Anirban Sengupta, Soham Mitra, Arindam Bhattacharyya
Modulation of pro-inflammatory and anti-inflammatory axis and orientation of glial cell function towards neuroinflammation, were hallmark signs of cerebral malaria (CM). CM pathogenesis was concerned with the circulating levels of Interleukin 6 (IL 6) and Transforming growth factor β (TGF β). Definite roles of these two cytokines in brain related pathology remained largely unexplored. To study the effect of these two cytokines, we have examined changes in morphology and in activation profile of the glial cells after TGF β and IL 6 neutralization during CM in cortex and cerebellum of the Plasmodium berghei ANKA (PbA) infected male swiss albino mice...
August 10, 2017: Cytokine
https://www.readbyqxmd.com/read/28803695/stat3-down-the-r-h-oad
#5
Francois Renault-Mihara, Hideyuki Okano
No abstract text is available yet for this article.
August 10, 2017: Cytokine
https://www.readbyqxmd.com/read/28802996/il-33-matured-dendritic-cells-promote-th17-cell-responses-via-il-1%C3%AE-and-il-6
#6
Su-Ho Park, Myun Soo Kim, Hui Xuan Lim, Daeho Cho, Tae Sung Kim
IL-33 is associated with a variety of autoimmune diseases, such as sclerosis, inflammatory bowel disease, and rheumatoid arthritis. Although IL-33 is mainly involved in the induction of Th2 cells, however, the relationship between IL-33 and Th17 cells is still largely unknown. In this study, we investigated the effects of IL-33 on DC-mediated CD4(+) T cell activation and Th17 cell differentiation because DCs are essential cells for presenting self-antigens to CD4(+) T cells in autoimmune disease conditions...
August 10, 2017: Cytokine
https://www.readbyqxmd.com/read/28802664/cytokines-and-soluble-hla-g-levels-in-bone-marrow-stroma-and-their-association-with-the-survival-rate-of-patients-exhibiting-childhood-t-cell-acute-lymphoblastic-leukemia
#7
Renata Dos Santos Almeida, Alessandra Maria de Luna Ramos, Carlos Feitosa Luna, Francisco Pedrosa, Eduardo Antônio Donadi, Norma Lucena-Silva
Leukemic cells can induce defective expression of soluble factors and change marrow cytokine profile, leading to aberrant cell signaling, cell fixation and cell proliferation in bone marrow. T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive disorder which accounts for 15% of pediatric ALL. To evaluate the contribution of immunological factors on T-ALL survival, we measured Th1, Th2, Th17 cytokines and soluble HLA-G (sHLA-G) levels in bone marrow from 32 Brazilian children at diagnosis (D0), after induction (D19) and after consolidation (D49) of the chemotherapy phase...
August 9, 2017: Cytokine
https://www.readbyqxmd.com/read/28802663/peripheral-gamma-delta-t-cells-secrete-inflammatory-cytokines-in-women-with-idiopathic-recurrent-pregnancy-loss
#8
Ayantika Talukdar, Reeta Rai, K Aparna Sharma, D N Rao, Alpana Sharma
BACKGROUND: Gamma delta (γδ) T cells are known to link innate and adaptive immunity. Decidual γδ T cells are known to provide immunotolerance by producing IL-10 and TGF-β. In recurrent pregnancy loss (RPL) females, the role of peripheral γδ T cells remain unstudied. OBJECTIVE: To investigate the different phenotypes of γδ T cells in the peripheral blood of women with idiopathic RPL and their possible involvement in RPL condition. METHODS: A total of 120 women were recruited for the study...
August 9, 2017: Cytokine
https://www.readbyqxmd.com/read/28802168/impact-of-hepatitis-b-vaccination-on-hbsag-kinetics-interferon-inducible-protein-10-level-and-recurrence-of-viremia
#9
Amr Shaaban Hanafy
BACKGROUND AND AIMS: Persistent HBs antigenemia >1000IU/ml has a possibility of viral reactivation and HCC in 8%, so we investigated the effect of HBV vaccine on HBsAg, IP-10, and recurrence of viremia. METHODS: Group I: inactive carriers(n=100). Group II: CHB exposed to nucleos(t)ides (n=120) till 1year after HBe seroconversion and HBV DNA disappearance in HBeAg positive (n=60) or3years after DNA disappearance in HBeAg negativepatients (n=60). All showed persistent HBs antigenemia...
August 9, 2017: Cytokine
https://www.readbyqxmd.com/read/28800925/resveratrol-increases-phagocytosis-and-lipopolysaccharide-induced-interleukin-1%C3%AE-production-but-decreases-surface-expression-of-toll-like-receptor-2-in-thp-1-monocytes
#10
Susan J Zunino, Daniel H Hwang, Shurong Huang, David H Storms
THP-1 monocytes were used to evaluate the effects of physiological levels of resveratrol aglycone, resveratrol-3-O-glucuronide, resveratrol-4'-O-glucuronide, and resveratrol-3-O-sulfate on phagocytosis, IL-1β, IL-1α, and IL-18 production, viability, and TLR2 and TLR4 expression. THP-1 cells were treated with 1, 5, 10, and 15μM resveratrol or metabolites. Resveratrol-3-O-glucuronide, resveratrol-4'-O-glucuronide, and resveratrol-3-O-sulfate had no effect on the functional parameters tested. Resveratrol aglycone increased phagocytosis at concentrations of 5, 10, and 15μM and LPS-induced IL-1β production at concentrations of 10 and 15μM...
August 8, 2017: Cytokine
https://www.readbyqxmd.com/read/28800924/the-influence-of-macrophage-growth-factors-on-theiler-s-murine-encephalomyelitis-virus-tmev-infection-and-activation-of-macrophages
#11
Karin M Schneider, Neva B Watson, Scott B Minchenberg, Paul T Massa
Macrophages are common targets for infection and innate immune activation by many pathogenic viruses including the neurotropic Theiler's Murine Encephalomyelitis Virus (TMEV). As both infection and innate activation of macrophages are key determinants of viral pathogenesis especially in the central nervous system (CNS), an analysis of macrophage growth factors on these events was performed. C3H mouse bone-marrow cells were differentiated in culture using either recombinant macrophage colony stimulating factor (M-CSF) or granulocyte-macrophage colony-stimulating factor (GM-CSF), inoculated with TMEV (BeAn) and analyzed at various times thereafter...
August 8, 2017: Cytokine
https://www.readbyqxmd.com/read/28784590/vanillin-as-a-new-modulator-candidate-for-renal-injury-induced-by-cisplatin-in-experimental-rats
#12
Mohamed M Elseweidy, Mervat E Askar, Sahar E Elswefy, Mohamed Shawky
Cisplatin is commonly prescribed for the treatment of various solid tumors but its use is limited due to certain side effects and renal injury is a true example. Oxidative stress and inflammation may contribute to the cisplatin induced nephrotoxicity. Accordingly, we evaluated the effect of oral vanillin intake (100mg/kg body weight) daily for 4weeks to combat this hazard. The present results have demonstrated significant attenuation of oxidative stress and renal injury where reduced glutathione (GSH) showed significant increase along with malondialdehyde (MDA) decrease...
August 4, 2017: Cytokine
https://www.readbyqxmd.com/read/28780379/proinflammatory-cytokine-mif-plays-a-role-in-the-pathogenesis-of-type-2-diabetes-mellitus-but-does-not-affect-hepatic-mitochondrial-function
#13
Miriam Rodriguez-Sosa, Tecilli Cabellos-Avelar, Yuriko Sanchez-Zamora, Imelda Juárez-Avelar, Esperanza García-Reyes, Alejandra Lira-León, José Del Carmen Benítez-Flores, Thalia Pacheco-Fernández, Marcia Hiriart, Emma Berta Gutiérrez-Cirlos
BACKGROUND: Macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine that plays an important role in the pathogenesis of type 2 diabetes mellitus (T2DM). Although the effect of high glucose on liver function has been described, the role of MIF in hepatic mitochondrial function during T2DM has not been studied. OBJECTIVE: We examine the influence of MIF to hepatic mitochondrial function in T2DM mouse model. METHODS: WT and Mif(-/-) BALB/c mice were treated with a single dose of streptozotocin (STZ)...
August 2, 2017: Cytokine
https://www.readbyqxmd.com/read/28764974/associations-between-genetic-and-epigenetic-variations-in-cytokine-genes-and-mild-persistent-breast-pain-in-women-following-breast-cancer-surgery
#14
Kimberly E Stephens, Jon D Levine, Bradley E Aouizerat, Steven M Paul, Gary Abrams, Yvette P Conley, Christine Miaskowski
Persistent pain following breast cancer surgery is a significant problem. Both inherited and acquired mechanisms of inflammation appear to play a role in the development and maintenance of persistent pain. In this longitudinal study, growth mixture modeling was used to identify persistent breast pain phenotypes based on pain assessments obtained prior to and monthly for 6months following breast cancer surgery. Associations between the "no pain" and "mild pain" phenotypes and single nucleotide polymorphisms (SNPs) spanning 15 cytokine genes were evaluated...
July 29, 2017: Cytokine
https://www.readbyqxmd.com/read/28760408/relationship-between-serum-inflammatory-markers-and-vascular-function-in-a-cohort-of-adolescents-with-type-1-diabetes
#15
Etienne Sochett, Damien Noone, Michael Grattan, Cameron Slorach, Rahim Moineddin, Yesmino Elia, Farid H Mahmud, David B Dunger, Neil Dalton, David Cherney, James Scholey, Heather Reich, John Deanfield
OBJECTIVE: The contribution of inflammation to endothelial/vascular dysfunction in early Type I Diabetes (T1D) is not well understood. The objective of this study was to examine the interaction between systemic inflammation and vascular function in adolescent's with and without-T1D. METHODS: 51 subjects from our observational cohort of adolescents with T1D (JDRF-CCTN), and 59 healthy controls (HC) were studied. Serum cytokines-chemokines were quantified using Human 41-Plex Array, and vascular function was measured by Flow Mediated Dilatation (FMD), Pulse Wave Velocity (PWV) and Blood Pressure (BP)...
July 28, 2017: Cytokine
https://www.readbyqxmd.com/read/28757363/poly-i-c-alleviates-obesity-related-pro-inflammatory-status-and-promotes-glucose-homeostasis
#16
Ying-Hui Wang, Yu-Gen Zhang
Obesity associated insulin resistance (IR) is implicated in chronic inflammation that mediated by the immune system. Imbalance between anti-inflammatory and pro-inflammatory response contributes to the origins and drivers of IR. However, cells of innate and adaptive immune system participate in the pathogenesis of IR, while glucose homeostasis related immune tolerance could be compromised high fat diet (HFD) reduced metabolic disorder. Although previous studies have demonstrated that anti-inflammatory therapy has a protective role in alleviating the pro-inflammatory status in HFD induced IR, the precise mechanism is still unclear...
July 27, 2017: Cytokine
https://www.readbyqxmd.com/read/28757362/dynamized-ethyl-alcohol-improves-immune-response-and-behavior-in-murine-infection-with-trypanosoma-cruzi
#17
Patrícia F Sandri, Angela R Portocarrero, Larissa Ciupa, Fabiana N Ferraz, Gislaine J Falkowski-Temporini, Willian N S Rodrigues, Érika C Ferreira, Denise L Aleixo, Silvana Marques de Araújo
AIM: To evaluate the effects of dynamized ethyl alcohol (Ethylicum)6cH and 30cH in mice infected with T. cruzi. METHODS: In a blind, randomized and controlled assay, 63 eight-week-old, Swiss, male mice, infected with IP (1400 trypomastigotes, T. cruzi-Y-strain), were allocated into groups: CNI-non-infected (n=12), CI-infected and non-treated (n=17), Et6cH-infected, treated with Ethylicum 6cH (dilution 1:10(12)) (n=17), Et30cH-infected, treated with Ethylicum 30cH (dilution 1:10(60)) (n=17)...
July 27, 2017: Cytokine
https://www.readbyqxmd.com/read/28757361/phosphorus-protects-cardiac-tissue-by-modifying-the-immune-response-in-rats-infected-by-trypanosoma-cruzi
#18
Érika Cristina Ferreira, Larissa Ciupa, Angela Rigo Portocarrero, Camila Fernanda Brustolin, Paula Fernanda Massini, Denise Lessa Aleixo, Silvana Marques de Araújo
AIM: This study evaluates and correlates the number of myocarditis focuses and production of cytokines in Rattus norvegicus (Wistar lineage), experimentally infected with T. Cruzi and treated with Phosphorus. METHODS: In two blind, controlled and randomized trials, 53 45-day-old, male animals were allocated into groups Control (n=24): Control group infected and treated with 7% hydroalcoholic solution, the preparation vehicle of the test medication; and Phosphorus (n=24 on days 0, 5, 10 and 24 after infection): group infected and treated with Phosphorus 13cH, diluted 10(-26) and dynamized (test medication)...
July 27, 2017: Cytokine
https://www.readbyqxmd.com/read/28756336/tnf%C3%AE-and-il-1%C3%AE-in-the-synovial-fluid-facilitate-mucosal-associated-invariant-t-mait-cell-migration
#19
Miok Kim, Su-Jin Yoo, Seong Wook Kang, Jaeyul Kwon, Inpyo Choi, Chang Hoon Lee
Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease that primarily affect the joints and inflammatory cell migration into inflamed articular sites contribute to this disease. Among the inflammatory cells, human mucosal-associated invariant T (MAIT) cells were recently recognized as critical cellular component with a pathological role in RA. However, their migratory characteristics are poorly understood. The aim of this study was to determine whether human MAIT cells preferentially traffick to inflamed synovial sites in rheumatoid arthritis patients and to elucidate the underlying mechanism...
July 27, 2017: Cytokine
https://www.readbyqxmd.com/read/28756107/s100a12-cd36-axis-a-novel-player-in-the-pathogenesis-of-atherosclerosis
#20
Jamileh Farokhzadian, Parvin Mangolian Shahrbabaki, Vahid Bagheri
S100A12 is a member of the S100 family of EF-hand calcium-binding proteins and have a variety of intracellular and extracellular activities. It exerts its proinflammatory effects by binding to the receptor for advanced glycation end products (RAGE) and Toll-like receptor 4 (TLR4). CD36 is a class B scavenger receptor that acts as a fatty acid transporter. Both S100A12 and CD36 are implicated in vascular inflammation and atherosclerosis. It has recently been demonstrated that S100A12 binds with high affinity to CD36...
July 26, 2017: Cytokine
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