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Betsy Annel González-Quezada, Hilario Flores-Aguilar, Alberto Olaya-Vargas, Haydee Salazar-Rosales, Martín Pérez-García, Luis Manuel Valero-Saldaña, Brenda Lizeth Acosta-Maldonado, Roberto Ovilla-Martínez, Clara Gorodezky
Acute lymphoblastic leukemia (ALL), the most common type of cancer in children worldwide, has one of the highest incidence rates in Mexico. It is a multifactorial disease and different cytokine single nucleotide polymorphisms (SNP), have been associated with ALL expression. Few studies have been published analyzing IFNG +874 T/A and IL2 -330 G/T in this type of leukemia. These SNPs are involved in high or low expression, and are central to cellular immunity, influencing greatly tumor growth. The purpose of this work was to explore the association of IFNG +874 A/T (rs2430561) and IL2 -330 G/T (rs2069762) SNPs with ALL susceptibility and/or protection in 488 Mexican Mestizos patients, as compared to 950 Mexican Mestizo healthy controls...
September 10, 2018: Cytokine
Sophia Magkouta, Androniki Kollintza, Charalampos Moschos, Magdalini Spella, Ioannis Skianis, Apostolos Pappas, Maria-Eleni Vazakidou, Georgios Stathopoulos, Ioannis Kalomenidis
BACKGROUND AND OBJECTIVE: Anti-angiogenic treatment has been recently shown to be clinically beneficial for mesothelioma patients. Angiopoietins-1 and -2 are key regulators of tumor angiogenesis. Ang-1 is mainly known to promote angiogenesis and vessel stability, while Ang-2 could serve as an antagonist of Ang-1 causing vessel regression and destabilization or enhance angiogenesis in a context-dependent manner. We hypothesized that Ang-1 would promote and Ang2 would halt experimental mesothelioma by affecting tumor angiogenesis...
September 7, 2018: Cytokine
Jorge Rodrigues de Sousa, Raimunda do Socorro da Silva Azevedo, Arnaldo Jorge Martins Filho, Marialva Tereza Ferreira de Araujo, Ermelinda do Rosário Moutinho Cruz, Barbara Cristina Baldez Vasconcelos, Ana Cecilia Ribeiro Cruz, Consuelo Silva de Oliveira, Livia Caricio Martins, Beatriz Helena Baldez Vasconcelos, Livia Medeiros Neves Casseb, Jannifer Oliveira Chiang, Juarez Antonio Simões Quaresma, Pedro Fernando da Costa Vasconcelos
Zika virus (ZIKV) has caused substantial concern worldwide owing to its association with severe birth defects, such as microcephaly and other congenital malformations. Inflammasomes, i.e., multi-protein complexes that induce inflammation and pyroptosis, are predicted to contribute to the immune response to this flavivirus. Accordingly, in this study, the in situ inflammasome response was evaluated in fatal cases of ZIKV-linked microcephaly. Brain tissue samples were collected from eight babies, including four ZIKV-positive microcephalic neonates who died after birth and four flavivirus-negative neonatal controls who died of other causes and whose central nervous system (CNS) architecture was preserved...
September 7, 2018: Cytokine
Vanessa Aust, Eugenia Kress, Stephanie Abraham, Nicole Schröder, Markus Kipp, Matthias B Stope, Thomas Pufe, Simone C Tauber, Lars-Ove Brandenburg
Pneumococcal meningitis, caused by Streptococcus pneumoniae, is the most common type of bacterial meningitis. The clinical management of this disease has been challenged by the emergence of multidrug-resistant Streptococcus pneumoniae, requiring the urgent development of new therapeutic alternatives. Over the course of bacterial meningitis, pathogen invasion is accompanied by a massive recruitment of peripheral immune cells, especially neutrophil granulocytes, which are recruited under the coordination of several cytokines and chemokines...
September 7, 2018: Cytokine
Jia Zhang, Jianbin Bi, Yifan Ren, Zhaoqing Du, Teng Li, Qingshan Li, Mengyun Ke, Jian Dong, Yi Lv, Rongqian Wu
BACKGROUND & AIMS: Gut ischemia reperfusion (I/R) injury is a life-threatening condition. The immune response plays an important role in I/R-induced organ injury. Alpha-galactosylceramide (α-GalCer) is a potent natural killer T (NKT) cell stimulator. Activation of NKT cells by α-GalCer has been shown to reduce I/R-induced injury in the liver and heart. However, whether α-GalCer has any protective effects on gut I/R-induced organ injury remained unknown. The aim of this study was to test the hypothesis that α-GalCer attenuates gut I/R-induced local and remote organ injury through modulating immune responses...
September 6, 2018: Cytokine
Xingmu Wang, Feiying Yang, Guangen Xu, Shuping Zhong
BACKGROUND: Recently, the roles of interleukin-6 (IL-6), IL-8 and IL-10 gene polymorphisms in gastric cancer have been extensively studied, with conflicting results. Therefore, we conducted the present study to better assess the potential correlations between these interleukin gene polymorphisms and gastric cancer. METHODS: Eligible articles were searched in PubMed, Medline, Embase, Web of Science and CNKI. Odds ratios (ORs) and 95% confidence intervals (CIs) were used to detect any potential associations between interleukin gene polymorphisms and the risk of gastric cancer...
September 6, 2018: Cytokine
Tracey A Edgell, Jemma Evans, Leah Lazzaro, Kendra Boyes, Meghana Sridhar, Sally Catt, Luk J F Rombauts, Beverley J Vollenhoven, Lois A Salamonsen
The endometrium lines a women's uterus becoming receptive, and allowing embryo implantation to occur, for just a few days during the post-ovulatory mid-secretory phase of each menstrual cycle. We investigated whether concentrations of proposed receptivity biomarkers (VEGF, IL8, FGF2, CSF3 sFlt-1, sGP130 and PlGF) secreted by the endometrium into the uterine cavity and forming the microenvironment for embryo implantation is altered among a population of age-matched women with unexplained (idiopathic) infertility compared to fertile women during the receptive mid-secretory phase (n = 16 fertile, 18 infertile) and the prior pre-receptive early secretory phase (n = 19 fertile, 18 infertile) of their cycle...
September 5, 2018: Cytokine
Di Che, Lei Pi, Yufen Xu, LanYan Fu, Huazhong Zhou, Zhouping Wang, Ping Huang, Li Zhang, Xiaoqiong Gu
Kawasaki disease is a multi-system vasculitis and a primary cause of acquired heart disease among children. Genetic factors may increase susceptibility to Kawasaki disease. TBXA2R is a G-protein-coupled receptor that participates in tissue inflammation and is associated with susceptibility to several diseases, but its relevance in Kawasaki disease is unclear. We genotyped TBXA2R (rs1131882 and rs4523) in 694 Kawasaki disease cases and 657 healthy controls. Odds ratios (ORs) and 95% confidence intervals (CIs) were used to evaluate the intensity of the associations...
September 1, 2018: Cytokine
Xiang Hu, Huamin Wang, Chaofeng Han, Xuetao Cao
The balance between pro-inflammatory and anti-inflammatory macrophage generation, a process known as polarization, is critical for immune homoeostasis. Identifying the molecular mechanisms underlying polarization and the generation of anti-inflammatory macrophages is an area of high current interest. Our previous work has demonstrated that integrin CD11b promotes IL-10 production in macrophages by activating the Sarcoma gene (Src), yet whether and how Src modulates anti-inflammatory macrophages is not known...
August 31, 2018: Cytokine
Renato Mastrangeli, Wolf Palinsky, Horst Bierau
All type I interferons share structural homology and bind to a common heterodimeric receptor consisting of the IFNAR1 and IFNAR2 subunits, which are expressed on most cell types. Although binding to the same receptor pair, they evoke a broad range of activities within the cell affecting the expression of numerous genes and resulting in profound cellular changes. Differential activation results from multiple levels of cellular and molecular events including binding affinity, receptor density, cell type-specific variations, and post-translational modification of signaling molecules downstream...
August 31, 2018: Cytokine
Xin Yi, Jinxue Zhang, Ran Zhuang, Song Wang, Shiyang Cheng, Dongliang Zhang, Jiangang Xie, Wei Hu, Xueqin Liu, Yun Zhang, Yong Ding, Yuan Zhang
Formation of macrophage-derived foam cells may mark the initial stages of atherosclerosis. We investigated the association between the expression of the leukocyte-associated immunoglobulin-like receptor 1 (LAIR-1) in macrophages and foam cell formation. A foam cell model was established by incubating THP-1-derived macrophages and bone marrow macrophages (BMMs) with oxidized low-density lipoprotein (ox-LDL). The role of LAIR-1 in foam cell formation was evaluated via Oil Red O staining and Dil-ox-LDL fluorescence intensities...
August 31, 2018: Cytokine
Alessandro P Delitala, Maristella Steri, Edoardo Fiorillo, Michele Marongiu, Edward G Lakatta, David Schlessinger, Francesco Cucca
OBJECTIVE: Cytokines release by adipocytes could interact with TSH secretion. We evaluated the relationship between adipocytokines and TSH. We further tested for association of cytokines and thyroid autoimmunity. METHODS: We conducted a cross-sectional study in a community-based sample including 5385 individuals (2964 female) with TSH within the reference range. Subjects who reported taking thyroid medications or drugs that alter thyroid function were excluded. TSH, FT4, adiponectin, leptin, antibody against thyroperoxidase and against thyroglobulin were measured...
August 30, 2018: Cytokine
Kazuhisa Furue, Takamichi Ito, Masutaka Furue
Psoriasis and psoriatic arthritis cause significant physical and psychological burdens for afflicted individuals. An accelerated TNF-α/IL-23/IL-17 axis is their major pathomechanism; therefore, anti-TNF-α/IL-23/IL-17 biologics are very effective for the treatment of skin and joint lesions in psoriasis and psoriatic arthritis. Given that the IL-17 signature is more upregulated in the skin than in synovium in psoriatic arthritis, anti-IL-23/IL-17 agents seem to be superior to anti-TNF-α remedies in the treatment of skin lesions...
August 29, 2018: Cytokine
Ken-Ichiro Sasaki, Yuta Ishizaki, Motoki Sasaki, Takaharu Nakayoshi, Masanori Ohtsuka, Hiroo Matsuse, Naoto Shiba, Takafumi Ueno, Yoshihiro Fukumoto
The hybrid training system (HTS) is a special and compact system for effective skeletal muscle training by a combined application of volitional and electrical muscle contraction. Lower limbs' muscle training using HTS has been reported to increase not only muscle strength but also plasma interleukin-6 levels; however, little is known in other cytokines. In this study, we measured 52 cytokines and creatine phosphokinase-MM in the serum of 16 healthy men before and after lower limbs' muscle training by the knee flexion and extension using HTS...
August 29, 2018: Cytokine
N Kouvas, C Kontogiannis, G Georgiopoulos, M Spartalis, D I Tsilimigras, E Spartalis, A Kapelouzou, M Kosmopoulos, S Chatzidou
The network of cytokines consists one of the most extensively studied signaling systems of human body. Cytokines appear to modulate pathogenesis and progress of many different diseases in the human body, particularly in regards to cardiovascular system. However, their effects on the electrical system of the heart has been neglected. Over the past decade, attemps to understand this relationship led to the uncovering of the direct and indirect effects of cytokines on action potential propagation and cell depolarization...
August 29, 2018: Cytokine
Youjin Li, Jie Chen, Xiaoqing Rui, Niu Li, Fan Jiang, Jun Shen
BACKGROUND: Allergic rhinitis (AR) is one of the most common respiratory diseases in children. It is caused by a combination of genetic and environmental factors. Moderate-to-severe AR decreases the quality of life and social performance in children. OBJECTIVE: To investigate whether polymorphisms in previously published genome-wide association studies (GWAS) allergic disease loci are associated with childhood AR and the severity of AR symptoms in a Chinese Han population...
August 28, 2018: Cytokine
Seok-Seong Kang, A Reum Kim, Cheol-Heui Yun, Seung Hyun Han
Secondary bacterial infection contributes to severe inflammation following viral infection. Among foodborne pathogenic bacteria, Staphylococcus aureus is known to exacerbate severe inflammatory responses after infection with single-stranded RNA viruses such as influenza viruses. However, it has not been determined if S. aureus infection enhances inflammatory responses after infection with RNA enteric viruses, including rotavirus, which is a double-stranded RNA virus. We therefore investigated the molecular mechanisms by which a cell wall component of S...
August 25, 2018: Cytokine
Deepti Rane, Tejaswini Patil, Vasundhara More, Sushree Sangita Patra, Neeelam Bodhale, Jagneswar Dandapat, Arup Sarkar
Neutrophils are short-living innate immune cells present in abundance in the circulation and they provide the first line of defense against infection. Microbicidal effector functions of the immune cells are tightly linked with their metabolic state. Overall knowledge of the association of neutrophil defense with cellular metabolism is still elusive. Recent studies have reported that neutrophil metabolism during granulopoiesis is impacted by the homeostatic process of autophagy. Autophagy is a complex process of which the subtype xenophagy, an antimicrobial autophagic process, clears invading pathogens...
August 23, 2018: Cytokine
Zhengxiang He, Lili Chen, Glaucia C Furtado, Sergio A Lira
Interleukin 33 (IL33) is a cytokine found in the extracellular space (mature IL33) or in the cell nucleus (full-length IL33). Nuclear accumulation of IL33 has been reported in intestinal epithelial cells (IEC) during intestinal inflammation and cancer, but a functional role for this nuclear form remains unclear. To study the role of nuclear IL33 in IEC, we generated transgenic mice expressing full-length IL33 in the intestinal epithelium (Vfl33 mice). Expression of full-length IL33 in the epithelium resulted in accumulation of IL33 protein in the nucleus and secretion of IL33...
August 23, 2018: Cytokine
Tejaswini Patil, Vasundhara More, Deepti Rane, Arkajyoti Mukherjee, Rahul Suresh, Ashok Patidar, Neelam Bodhale, David Mosser, Jagneshwar Dandapat, Arup Sarkar
Leishmania is an obligate intracellular parasite uses low pH phagolysosomal compartments of host macrophages as their final abode. IL-1β is a pro inflammatory cytokine, which is secreted by immune cells to trigger inflammation and this has been found profoundly in the lesions caused by Leishmania pathogens. But the specific role of this cytokine on host cell macrophages during infection has not been fully explored. Here in, we have showed that prolonged exposure of IL-1β on macrophages increases the parasite burden...
August 22, 2018: Cytokine
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