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Human & Experimental Toxicology

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https://www.readbyqxmd.com/read/28090784/effect-of-resveratrol-and-tetracycline-on-the-subacute-paraquat-toxicity-in-mice
#1
R M Satpute, P P Pawar, S Puttewar, S D Sawale, P D Ambhore
Paraquat (PQ) is a nonselective bipyridyl herbicide widely used in agriculture to control weeds, but its accidental, occupational, or intentional exposure in humans is known to cause pneumo- and neurotoxicity which may proves fatal. Oxidative stress is reported as an underlined mechanism of PQ-induced toxicity in alveolar cells, neurons, and astroglia. PQ generates superoxides both through electron transport reaction (ETC) with nicotinamide adenine dinucleotide-dependent oxidoreductase and by the redox cycling via reaction with molecular oxygen...
January 1, 2017: Human & Experimental Toxicology
https://www.readbyqxmd.com/read/28084090/protective-effects-of-salidroside-against-isoflurane-induced-cognitive-impairment-in-rats
#2
L Liang, Z Ma, M Dong, J Ma, A Jiang, X Sun
Postoperative cognitive dysfunction, which is associated with a wide range of cognitive functions including working memory, long-term memory, information processing, attention, and cognitive flexibility, is a major clinical issue in geriatric surgical patients. The aim of the current study was to determine the protective role and possible mechanisms of salidroside against isoflurane-induced cognitive impairment. Sprague Dawley rats were randomly assigned to five groups and were treated with or without salidroside before isoflurane exposure...
January 1, 2017: Human & Experimental Toxicology
https://www.readbyqxmd.com/read/28084089/metabolic-changes-in-rat-serum-after-administration-of-suberoylanilide-hydroxamic-acid-and-discriminated-by-svm
#3
J Yu, H Wu, Z Lin, K Su, J Zhang, F Sun, X Wang, C Wen, H Cao, L Hu
Suberoylanilide hydroxamic acid (SAHA) exerts marked anticancer effects via promotion of apoptosis, cell cycle arrest, and prevention of oncogene expression. In this study, serum metabolomics and artificial intelligence recognition were used to investigate SAHA toxicity. Forty rats (220 ± 20 g) were randomly divided into control and three SAHA groups (low, medium, and high); the experimental groups were treated with 12.3, 24.5, or 49.0 mg kg(-1) SAHA once a day via intragastric administration. After 7 days, blood samples from the four groups were collected and analyzed by gas chromatography-mass spectrometry, and pathological changes in the liver were examined using microscopy...
January 1, 2017: Human & Experimental Toxicology
https://www.readbyqxmd.com/read/28078916/in-vivo-protection-studies-of-bis-quaternary-2-hydroxyimino-n-pyridin-3-yl-acetamide-derivatives-hnk-oximes-against-tabun-and-soman-poisoning-in-swiss-albino-mice
#4
P Kumar, D Swami, D P Nagar, K P Singh, J Acharya, H N Karade, R Yadav
The study reports antidotal efficacy of three HNK [ bis quaternary 2-(hydroxyimino)-N-(pyridin-3yl) acetamide derivatives] and pralidoxime (2-PAM), against soman and tabun poisoning in Swiss albino mice. Protection index (PI) was determined (treatment doses: HNK oximes, ×0.20 of their median lethal dose (LD50) and 2-PAM, 30 mg/kg, intramuscularly (im)) together with atropine (10 mg/kg, intraperitoneally). Probit log doses with difference of 0.301 log of LD50 of the nerve agents administered and inhibition of acetylcholinesterase (AChE) activity by 50% (IC50) was calculated at optimized time in brain and serum...
January 1, 2017: Human & Experimental Toxicology
https://www.readbyqxmd.com/read/28071240/teucrium-polium-hexane-extract-downregulated-androgen-receptor-in-testis-and-decreased-fertility-index-in-rats
#5
Aaa Al-Tikriti, E Al-Khateeb, M A Abbas
Teucrium polium L. (Lamiaceae) is a commonly used medicinal plant in folk medicine. Among several uses, T. polium is used to treat male fertility problems. This research was conducted to study the effect of T. polium on spermatogenesis, testosterone level, androgen receptor expression, and fertility in male rats. Administration of hexane extract for 6 days to aging rats increased testosterone level. When administered for 60 days, T. polium hexane extract downregulated androgen receptors, decreased sperm count without producing histological changes in different stages of spermatogenesis...
January 1, 2017: Human & Experimental Toxicology
https://www.readbyqxmd.com/read/28071239/induction-by-arsenate-of-cell-type-specific-cytotoxic-effects-in-nerve-and-hepatoma-cells
#6
Wafa Kharroubi, Thomas Nury, Samia Haj Ahmed, Pierre Andreoletti, Rachid Sakly, Mohamed Hammami, Gérard Lizard
The aim of the study was to compare the effect of sodium arsenate (AsV) on two different cell types: 158N murine oligodendrocytes and HepG2 human hepatoma cells. Exposure of 158N cells to AsV (0.1-400 µM; 48 h) induced a biphasic cytoxic effect defined as hormesis. Thus, low concentrations of AsV stimulate cell proliferation, as shown by phase-contrast microscopy, cell counting with trypan blue, and crystal violet assay, whereas high concentrations induce cell death associated with a loss of cell adhesion...
January 1, 2017: Human & Experimental Toxicology
https://www.readbyqxmd.com/read/27941169/nilotinib-attenuates-endothelial-dysfunction-and-liver-damage-in-high-cholesterol-fed-rabbits
#7
D S El-Agamy
Nilotinib is an oral potent tyrosine kinase inhibitor that has diverse biological activities. However, its effects on hypercholesterolemia and associated disorders have not been studied yet. The present study explored the effect of nilotinib on atherosclerosis progression, endothelial dysfunction, and hyperlipidemia-associated hepatic injury in high-cholesterol (HC)-fed rabbits. Rabbits were classified into four groups: control, nilotinib, HC, and HC + nilotinib groups. Rabbits were fed either a regular diet or an HC-enriched diet for 8 weeks...
December 9, 2016: Human & Experimental Toxicology
https://www.readbyqxmd.com/read/27941168/wogonoside-exerts-growth-suppressive-effects-against-t-acute-lymphoblastic-leukemia-through-the-stat3-pathway
#8
R Xiao, M Gan, T Jiang
Wogonoside is the main flavonoid of the traditional Chinese medicinal herb Scutellaria baicalensis Georgi and has been found to induce growth suppression in myelogenous leukemia cells. However, its activity in T acute lymphoblastic leukemia (T-ALL) is still unclear. In this study, T-ALL cell lines MOLT-3 and Jurkat were exposed to different concentrations of wogonoside for 48 h, and cell viability, cell cycle distribution, and apoptosis were measured. The involvement of signal transducers and activators of transcription 3 (STAT3) signaling in the activity of wogonoside was checked...
December 9, 2016: Human & Experimental Toxicology
https://www.readbyqxmd.com/read/27941167/protective-effects-of-dietary-selenium-and-vitamin-c-in-barium-induced-cardiotoxicity
#9
Awatef Elwej, Imen Ghorbel, Mariem Chaabane, Nejla Soudani, Rim Marrekchi, Kamel Jamoussi, Hela Mnif, Tahia Boudawara, Najiba Zeghal, Mediha Sefi
Several metals including barium (Ba) known as environmental pollutants provoke deleterious effects on human health. The present work pertains to the potential ability of selenium (Se) and/or vitamin C, used as nutritional supplements, to alleviate the toxic effects induced by barium chloride (BaCl2) in the heart of adult rats. Animals were randomly divided into seven groups of six each: group 1, serving as negative controls, received distilled water; group 2 received in their drinking water BaCl2 (67 ppm); group 3 received both Ba and Se (sodium selenite 0...
December 9, 2016: Human & Experimental Toxicology
https://www.readbyqxmd.com/read/27941166/study-of-commonly-used-organophosphate-pesticides-that-induced-oxidative-stress-and-apoptosis-in-peripheral-blood-lymphocytes-of-rats
#10
A Ojha, Y K Gupta
In a previous study, we have found that organophosphate (OP) pesticides such as chlorpyrifos (CPF), methyl parathion (MPT), and malathion (MLT) significantly induced genotoxicity in peripheral blood lymphocytes of rats. To explore the mechanism of OP-induced genotoxicity, we measured the formation of DNA interstrand cross-links (DICs) and apoptosis in peripheral blood lymphocytes of rats. Peripheral blood lymphocytes of rats were treated with CPF, MPT, and MLT individually and in combination at concentrations of 0...
December 9, 2016: Human & Experimental Toxicology
https://www.readbyqxmd.com/read/27932539/assessment-of-concomitant-versus-sequential-trastuzumab-on-radiation-induced-cardiovascular-toxicity
#11
G Yavas, M Gultekin, O Yildiz, M Seyrek, S Demirkol, H Toy, M F Sargon, O Ozkayar, A Uner, F Yildiz, F Akyol
There are limited data regarding effect of trastuzumab on radiation-induced cardiovascular toxicity when used sequentially or concomitantly. This experimental study aims to investigate effect of trastuzumab on radiation-induced cardiovascular toxicity with respect to the treatment sequence. One hundred and eight female Wistar albino rats were divided into six groups (G): G1 was control, G2 was trastuzumab, and G3 was radiotherapy (RT); G4 and G6 were sequential RT and trastuzumab; and G5 was concomitant RT and trastuzumab groups, respectively...
December 8, 2016: Human & Experimental Toxicology
https://www.readbyqxmd.com/read/27932538/investigation-of-solid-particles-in-the-mainstream-aerosol-of-the-tobacco-heating-system-ths2-2-and-mainstream-smoke-of-a-3r4f-reference-cigarette
#12
P Pratte, S Cosandey, C Goujon Ginglinger
Combustion of biomass produces solid carbon particles, whereas their generation is highly unlikely when a biomass is heated instead of being burnt. For instance, in the Tobacco Heating System (THS2.2), the tobacco is heated below 350°C and no combustion takes place. Consequently, at this relatively low temperature, released compounds should form an aerosol consisting of suspended liquid droplets via a homogeneous nucleation process. To verify this assumption, mainstream aerosol generated by the heat-not-burn product, THS2...
December 8, 2016: Human & Experimental Toxicology
https://www.readbyqxmd.com/read/27920337/effect-of-epigallocatechin-3-gallate-on-acrylamide-induced-oxidative-stress-and-apoptosis-in-pc12-cells
#13
Y He, D Tan, Y Mi, B Bai, D Jiang, X Zhou, S Ji
Acrylamide (ACR) is a chemical intermediate utilized in industry. ACR is also formed during heating of foods containing carbohydrates and amino acids. Therefore, humans are widely exposed to ACR, and ACR neurotoxicity in humans is a significant public health issue attracting wide attention. In this study, we investigated the potential neuroprotective effects of epigallocatechin-3-gallate (EGCG), the most abundant polyphenolic compound in green tea, in PC12 cells treated with ACR. ACR-treated PC12 cells pretreated with various concentrations of EGCG (2...
December 5, 2016: Human & Experimental Toxicology
https://www.readbyqxmd.com/read/27903879/the-analysis-of-qt-interval-and-repolarization-morphology-of-the-heart-in-chronic-exposure-to-lead
#14
J Kiełtucki, M Dobrakowski, N Pawlas, B Średniawa, M Boroń, S Kasperczyk
There are no common recommendations regarding electrocardiographic monitoring in occupationally exposed workers. Therefore, the present study was designed to investigate whether exposure to lead results in an increase of selected electrocardiography (ECG) pathologies, such as QT interval prolongation and repolarization disorders, in occupationally exposed workers. The study group included 180 workers occupationally exposed to lead compounds. The exposed group was divided according to the median of the mean blood lead level (PbBmean) calculated based on a series of measurements performed during 5-year observation period (35 µg/dl) into two subgroups: low exposure (LE, PbBmean = 20...
November 30, 2016: Human & Experimental Toxicology
https://www.readbyqxmd.com/read/27895099/new-thiazacridine-agents-synthesis-physical-and-chemical-characterization-and-in-vitro-anticancer-evaluation
#15
Mbo Chagas, Ncc Cordeiro, Kmr Marques, M G Rocha Pitta, Mjbm Rêgo, McA Lima, Mgr Pitta, I R Pitta
A series of new thiazacridine agents were synthesized and evaluated as antitumor agents, in terms of not only their cytotoxicity but also their selectivity. The cytotoxicity assay confirmed that all compounds showed cytotoxic activity and selectivity. The new compound, 3-acridin-9-ylmethyl-5-(5-bromo-1H-indol-3-ylmethylene)-thiazolidine-2,4-dione (LPSF/AA29 - 7A: ), proved to be the most promising compound as it presents lower half-maximal inhibitory concentration (IC50) values (ranging from 0.25 to 68.03 µM) depending on cell lineage...
November 27, 2016: Human & Experimental Toxicology
https://www.readbyqxmd.com/read/27895098/brain-aluminium-accumulation-and-oxidative-stress-in-the-presence-of-calcium-silicate-dental-cements
#16
K Demirkaya, B Can Demirdöğen, Z Öncel Torun, O Erdem, E Çırak, Y M Tunca
Mineral trioxide aggregate (MTA) is a calcium silicate dental cement used for various applications in dentistry. This study was undertaken to test whether the presence of three commercial brands of calcium silicate dental cements in the dental extraction socket of rats would affect the brain aluminium (Al) levels and oxidative stress parameters. Right upper incisor was extracted and polyethylene tubes filled with MTA Angelus, MTA Fillapex or Theracal LC, or left empty for the control group, were inserted into the extraction socket...
November 27, 2016: Human & Experimental Toxicology
https://www.readbyqxmd.com/read/27885104/could-vitamin-c-and-zinc-chloride-protect-the-germ-cells-against-sodium-arsenite
#17
L S Altoé, I B Reis, Mlm Gomes, H Dolder, Jc Monteiro Pirovani
Arsenic (As) is commonly associated with natural and human processes such as volcanic emissions, mining and herbicides production, being an important pollutant. Several studies have associated As intake with male fertility reduction, thus the aim of the present study was to evaluate whether vitamin C and/or zinc would counteract As side effects within the testicles. Adult male Wistar rats were divided into six experimental groups: control, sodium arsenite (5 mg/kg/day), vitamin C (100 mg/kg/day), zinc chloride (ZnCl2; 20 mg/kg/day), sodium arsenite + vitamin C and sodium arsenite + ZnCl2 Testicles and epididymis were harvested and either frozen or routinely processed to be embedded in glycol methacrylate resin...
November 24, 2016: Human & Experimental Toxicology
https://www.readbyqxmd.com/read/27885103/no-support-for-lipid-rescue-in-oral-poisoning-a-systematic-review-and-analysis-of-160-published-cases
#18
M Forsberg, S Forsberg, G Edman, J Höjer
Lipid rescue is used as treatment of various poisonings despite weak scientific evidence. Some experimental studies have indicated a positive effect, but others have not. Clinical studies are lacking, wherefore a systematic review of virtually all published human case reports is presented. The case reports were searched for in PubMed and Web of Science and examined by two experts according to an assessment form grading the probability for a causal connection between lipid rescue and improved symptoms. A total of 160 cases were finally included, of which 30 had no positive effect of lipid rescue...
November 24, 2016: Human & Experimental Toxicology
https://www.readbyqxmd.com/read/27872163/role-of-autophagy-in-cadmium-induced-testicular-injury
#19
Y-J Wang, J Yan, F Yin, L Li, Y-G Qin, C-Y Meng, R-F Lu, L Guo
The testis is sensitive to cadmium, but studies investigating cadmium-induced testicular injury have not yet clearly revealed the underlying mechanisms. This study aimed to investigate the injurious effects of cadmium on rat testes and the role that autophagy plays in this process. Wistar rats were randomly divided into four groups and intraperitoneally injected with 0.2 (low), 0.4 (middle), and 0.8 mg/kg·body weight (high) cadmium chloride for 5 weeks, while the control rats were injected with equal volume of saline...
November 21, 2016: Human & Experimental Toxicology
https://www.readbyqxmd.com/read/27852938/does-maternal-exposure-to-artificial-food-coloring-additives-increase-oxidative-stress-in-the-skin-of-rats
#20
K Başak, P Y Başak, D K Doğuç, F Aylak, S Oğuztüzün, B M Bozer, F Gültekin
Glutathione-S-transferase (GST) and cytochrome P450 family 1 subfamily A polypeptide 1 (CYP1A1) metabolize and detoxify carcinogens, drugs, environmental pollutants, and reactive oxygen species. Changes of GST expression in tissues and gene mutations have been reported in association with many neoplastic skin diseases and dermatoses. Widely used artificial food coloring additives (AFCAs) also reported to effect primarily behavioral and cognitive function and cause neoplastic diseases and several inflammatory skin diseases...
November 16, 2016: Human & Experimental Toxicology
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