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DNA and Cell Biology

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https://www.readbyqxmd.com/read/30234381/a-three-long-noncoding-rna-based-signature-for-oral-squamous-cell-carcinoma-prognosis-prediction
#1
Chenguang Zhao, Huiru Zou, Jinhui Wang, Jun Shen, Hao Liu
Oral squamous cell carcinoma (OSCC) is one of the most common malignancies worldwide. Despite relative high 5-year survival rate, delayed diagnosis still hampers its prognosis improvement. Long noncoding RNA (lncRNA) has recently been demonstrated to involve in development of various cancers. This study aimed to identify a lncRNA-based signature by which we could accurately predict OSCC prognosis. We first downloaded the RNA sequencing datasets for OSCC from The Cancer Genome Atlas (TCGA) and divided samples into training set and validation set...
September 20, 2018: DNA and Cell Biology
https://www.readbyqxmd.com/read/30234378/identification-of-two-novel-single-nucleotide-polymorphyisms-in-the-promoter-region-of-the-pig-amp-deaminase-1-gene-associated-with-carcass-traits
#2
Linjie Wang, Zhe Chao, Yan Wang
The AMP deaminase 1 (AMPD1) gene plays an important role in purine nucleotide interconversion and energy metabolism. In this study, two novel single nucleotide polymorphyisms (SNPs) (g.-626 G > A and g.-566 A>G) were detected in the proximal promoter region of the AMPD1 gene. The Chinese indigenous pig breeds (Meishan and Tongcheng) had higher frequencies of the G and A alleles than Western meat-type breeds (Landrace and Large White) at the g.-626 G > A and g.-566 A>G loci. The transcriptional activity of the AMPD1 promoter carrying the haplotype H1 (A-626 G-566 ) was significantly (p < 0...
September 20, 2018: DNA and Cell Biology
https://www.readbyqxmd.com/read/30234372/molecular-mechanisms-of-phosphodiesterase-5-inhibitors-on-neuronal-apoptosis
#3
Eduardo Duarte-Silva, Christina Alves Peixoto
Phosphodiesterase-5 inhibitors (PDE5Is) have been shown to modulate cell death/cell survival in different in vivo and in vitro models of disease by activating many signaling pathways. This review aimed at elucidating how PDE5Is can inhibit apoptosis. In this study, we describe many signaling pathways involved with the mechanism of action of PDE5Is that ultimately inhibit apoptosis and thus promote cell survival.
September 20, 2018: DNA and Cell Biology
https://www.readbyqxmd.com/read/30230915/cardiac-fgf-16-expression-supports-cardiomyocyte-survival-and-increases-resistance-to-doxorubicin-cytotoxicity
#4
Jie Wang, Bo Xiang, Vernon W Dolinsky, Elissavet Kardami, Peter A Cattini
The fibroblast growth factor (FGF) 16 gene is preferentially expressed by cardiomyocytes after birth with levels increasing into adulthood. Null mice and isolated heart studies suggest a role for FGF-16 in cardiac maintenance and survival, including increased resistance to doxorubicin (DOX)-induced injury. A single treatment with DOX was also shown to rapidly deplete endogenous rat FGF-16 mRNA at 6 h in both adult heart and neonatal cardiomyocytes. However, the effect of DOX on rat cardiac function at the time of decreased FGF-16 gene expression and the effect of FGF-16 availability on cardiomyocyte survival, including in the context of acute DOX cytotoxicity, have not been reported...
September 19, 2018: DNA and Cell Biology
https://www.readbyqxmd.com/read/30230914/tgf-%C3%AE-smads-signaling-affects-radiation-response-and-prolongs-survival-by-regulating-dna-repair-genes-in-malignant-glioma
#5
Sichen Tao, Minli Liu, Dawei Shen, Wei Zhang, Tongxin Wang, Yunan Bai
To understand the molecular mechanism underlying the causal relationship between aberrant upregulation of transforming growth factor beta (TGF-β) and radio-resistance in glioma. The mouse glioma cell GL261 was irradiated, and relative expression of TGF-β/Smad signaling genes was determined by real-time PCR and western blotting. The DNA repair response on exogenous TGF-β or LY2109761 was evaluated by quantification of diverse genes by real-time PCR and western blotting. Xenograft mice were employed for in vivo investigation to assess the response to irradiation and LY2109761 either alone or in combination...
September 19, 2018: DNA and Cell Biology
https://www.readbyqxmd.com/read/30227089/gpr30-attenuates-myocardial-fibrosis-in-diabetic-ovariectomized-female-rats-role-of-inos-signaling
#6
Xiaowu Wang, Yanzhen Tan, Bo Xu, Linhe Lu, Minggao Zhao, Jipeng Ma, Hongliang Liang, Jincheng Liu, Shiqiang Yu
Premenopausal women have a reduced risk for cardiovascular disease. Estrogen deficiency augments cardiac inflammation and oxidative stress and, thereby, aggravates myocardial fibrosis (MF) and diastolic dysfunction in hypertensive female rats. However, estrogen replacement therapy has no effect on myocardial infarction and cardiac fibrosis in postmenopausal women. Further clinical studies showed that high blood glucose levels in patients with diabetes is an important cause of MF, but the underlying mechanism is unclear...
September 18, 2018: DNA and Cell Biology
https://www.readbyqxmd.com/read/30227079/optimized-gemcitabine-therapy-in-combination-with-e7-peptide-immunization-elicits-tumor-cure-by-preventing-ag-specific-ctl-inhibition-in-animals-with-large-established-tumors
#7
Ho-Young Jang, Baek-Sang Han, Byungsuk Kwon, Jeong-Im Sin
The role of chemotherapeutic agents in tumor immunotherapy is still controversial. In this study, we test using a TC-1 tumor model whether gemcitabine plus E7 peptide vaccine regimens (E7 peptides+CpG-ODN+anti-4-1BB Abs) may result in tumor cure in mice with large established tumors, with a focus on their effects on Ag-specific cytotoxic T lymphocyte (CTL) and myeloid-derived suppressor cell levels. Gemcitabine inhibited tumor growth by its direct cytotoxicity to tumor cells in vivo. E7 peptide vaccine regimens enhanced Ag-specific CTL lytic and antitumor therapeutic activity...
September 18, 2018: DNA and Cell Biology
https://www.readbyqxmd.com/read/30222366/roles-of-prion-protein-in-virus-infections
#8
Suehiro Sakaguchi, Junji Chida
The normal cellular prion protein, designated PrPC , is a membrane glycoprotein expressed most abundantly in brains, particularly by neurons, and to a lesser extent in non-neuronal tissues including lungs. Conformational conversion of PrPC into the amyloidogenic isoform is a key pathogenic event in prion diseases. We recently found that PrPC has a protective role against infection with influenza A viruses (IAVs) in mice by reducing reactive oxygen species in the lungs after infection with IAVs. The antioxidative activity of PrPC is probably attributable to its function to activate antioxidative enzyme Cu/Zn-superoxide dismutase, or SOD1, through regulating Cu content in lungs infected with IAVs...
September 14, 2018: DNA and Cell Biology
https://www.readbyqxmd.com/read/30207747/a-novel-variant-of-desmoplakin-is-potentially-associated-with-silicosis-risk
#9
Wei Wang, Yuhui Yu, Jing Xiao, Yuexia Gao, Lingli Sang, Yulong Lian, Yihua Lu, Tian Tian, Xun Zhuang, Lei Han, Minjie Chu
OBJECTIVES: Two genome-wide association studies and one sequencing study have coincidently reported significant associations of single nucleotide polymorphisms (SNPs) in the desmoplakin (DSP) gene with the risk of pulmonary fibrosis (mainly idiopathic pulmonary fibrosis). However, these findings have not been well generalized to occupational pulmonary fibrosis (e.g., silica-related silicosis). MATERIALS AND METHODS: We systematically genotyped 8 potentially functional SNPs and the previously reported rs2076295 and rs2744371 in DSP gene region and evaluated the associations between these 10 SNPs and silicosis risk in a case-control study that included 177 silicosis cases and 204 controls with similar numbers of silica dust exposure years as the cases from a Chinese population...
September 12, 2018: DNA and Cell Biology
https://www.readbyqxmd.com/read/30124330/overexpression-of-short-variant-form-of-new-kelch-family-protein-leads-to-erythroid-and-megakaryocyte-dysplasia-by-targeting-megakaryocyte-erythroid-progenitors
#10
Yansi Lin, Yuxuan Luo, Fangxiao Hu, Tongjie Wang, Yong Dong, Dan Yang, Xiaodan He, Xiaoli Chen, Jinyong Wang, Juan Du, Xiangzhong Zhang
Nd1-S is the nuclear-localizing short variant form of Nd1 (Ivns1abp) encoding a Kelch family transcription factor. While the function of Nd1 has been investigated in the context of metastasis and doxorubicin-induced cardiotoxicity, little is known about its role in hematopoiesis. In this study, we investigated the function of Nd1-S in hematopoiesis by transplanting the Nd1-S-overexpressing murine hematopoietic stem and progenitor cells (HSPCs) into recipient mice (Nd1-S mice). Enforced expression of Nd1-S led to erythroid and megakaryocyte dysplasia, demonstrated by dramatically decreased red blood cells and platelets, and megakaryocytes in the peripheral blood and bone marrow of the Nd1-S mice...
August 20, 2018: DNA and Cell Biology
https://www.readbyqxmd.com/read/30113225/host-genetic-polymorphisms-influencing-susceptibility-to-dengue
#11
Sudheer Gupta, Ankita Agarwal, Debasis Biswas
Dengue is a pandemic-prone viral disease which is endemic in more than 100 countries and which puts half of the world's population at risk. While the disease presents as subclinical infection or mild fever in the majority of cases, approximately a quarter of the infected individuals experience severe forms of disease like dengue hemorrhagic fever/dengue shock syndrome that cause significant rates of mortality and morbidity. The pathogenesis of this differential outcome of infection is determined by a complex interplay of factors associated with the virus, vector, and host; much of which is not completely understood...
August 16, 2018: DNA and Cell Biology
https://www.readbyqxmd.com/read/30113224/association-between-long-noncoding-rna-meg3-polymorphisms-and-lung-cancer-susceptibility-in-chinese-northeast-population
#12
Zitai Yang, Hang Li, Juan Li, Xiaoting Lv, Min Gao, Yanhong Bi, Ziwei Zhang, Shengli Wang, Sixuan Li, Na Li, Zhigang Cui, Baosen Zhou, Zhihua Yin
Long noncoding RNA (lncRNA) maternal-expressed gene 3 (MEG3) is associated with proliferation of various tumor cells and has decreased expression in many types of cancers. In this study, we aimed at demonstrating the association between MEG3 polymorphisms and the risk of lung cancer in northeast China. There were 526 lung cancer patients and 526 healthy controls included in this hospital-based case-control study. The genotyping of two polymorphisms, rs7158663 G > A and rs4081134 G>A, was performed by the Taqman allelic discrimination method...
August 16, 2018: DNA and Cell Biology
https://www.readbyqxmd.com/read/30113217/identification-of-lncrnas-and-their-functional-network-associated-with-chemoresistance-in-sw1990-gz-pancreatic-cancer-cells-by-rna-sequencing
#13
Duguang Li, Xiaowei Qian, Peng Xu, Xiaodong Wang, Zhennan Li, Jianjun Qian, Jie Yao
Drug resistance is a major problem in the treatment of pancreatic cancer (PC). Long noncoding (lnc)RNAs modulate a variety of cellular processes. This study was carried out to identify lncRNAs that are differentially expressed in drug-resistant PC by next-generation RNA sequencing. We identified 205 differentially expressed lncRNAs (DELs) and 847 differentially expressed mRNAs (DEMs) in a comparison of gemcitabine-resistant and -sensitive SW1990 human PC cells. The expression levels of 12 randomly selected lncRNAs were confirmed by quantitative real-time PCR...
August 16, 2018: DNA and Cell Biology
https://www.readbyqxmd.com/read/30102556/identification-and-multilineage-potential-research-of-a-novel-type-of-adipose-derived-mesenchymal-stem-cells-from-goose-inguinal-groove
#14
Caiyun Ma, Yu Guo, Hebao Wen, Yanjie Zheng, Leiqi Tan, Xiangchen Li, Chunjing Wang, Weijun Guan, Changqing Liu
Adipose tissue-derived mesenchymal stem cells (ADSCs) play a crucial role in the field of regenerative medicine and tissue repair for its own unique features. However, up to date, the isolation and characterizations of multidifferentiation potentials of goose ADSCs are still uncertain. In this study, we successfully isolated ADSCs from goose inguinal groove in vitro for the first time and also attempted to unravel its fundamental differentiation potentials and genetic characteristics. The results showed that isolated ADSCs exhibited a typical fibroblast-like morphology and high proliferative potential, could be passaged for at least 40 passages and maintained high hereditary stability with more than 92...
September 2018: DNA and Cell Biology
https://www.readbyqxmd.com/read/30096000/construction-expression-and-characterization-of-a-novel-human-mouse-chimeric-antibody-hm3a4-a-potential-therapeutic-agent-for-b-and-myeloid-lineage-leukemias
#15
Sisi Li, Diying Shen, Xiaoping Guo, Chan Liao, Yongmin Tang
Antibody-targeting therapy has drawn great interests to the hematologists and oncologists. 3A4, a novel antibody recognizing human CD45RA antigen, is a new target molecule for leukemias and holds a therapeutic potential for myeloid lineage leukemias. However, murine antibodies cannot be safely used in patients because of their strong immune reaction, humanization of the antibodies interested will be an important development step for therapeutic purpose. The aim of this study was to engineer the mouse 3A4 and to investigate the biological activity of its chimeric form...
September 2018: DNA and Cell Biology
https://www.readbyqxmd.com/read/30074406/lncrna-gas5-indel-genetic-polymorphism-contributes-to-glioma-risk-through-interfering-binding-of-transcriptional-factor-tfap2a
#16
Jupeng Yuan, Nasha Zhang, Yan Zheng, Yi-Dong Chen, Jie Liu, Ming Yang
Long noncoding RNA (lncRNA) growth arrest-specific 5 (GAS5) accumulates in growth-arrested cells and plays a crucial role in progression of multiple cancers, including glioma. There is a functional GAS5 rs145204276 indel genetic polymorphism in the promoter region. However, it is still largely unknown how the GAS5 indel genetic polymorphism is involved in etiology of glioma. We evaluated the association between the GAS5 indel genetic polymorphism and glioma development in a Chinese population. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated by logistic regression adjusted by age and sex...
September 2018: DNA and Cell Biology
https://www.readbyqxmd.com/read/30059260/human-adipose-derived-cd146-stem-cells-increase-life-span-of-a-muscular-dystrophy-mouse-model-more-efficiently-than-mesenchymal-stromal-cells
#17
Juliana P Gomes, Giuliana C Coatti, Marcos C Valadares, Amanda F Assoni, Mayra V Pelatti, Mariane Secco, Mayana Zatz
Duchenne muscular dystrophy is the most common and severe form of progressive muscular dystrophy. Previous results showed an increased survival in double knockout mice (dko) when treated with adipose-derived CD146+ cells. In this study, we analyzed the effect of CD146+ cells compared to mesenchymal stem/stromal cells (MSCs) derived from the same human adipose sample when injected in the dko mouse model without immunosuppression. Both CD146+ cells and MSCs increased the survival of treated mice when compared to vehicle-injected mice, with a more prominent effect of CD146+ cells than MSCs...
September 2018: DNA and Cell Biology
https://www.readbyqxmd.com/read/30059238/the-role-of-viperin-in-antiflavivirus-responses
#18
Richard Lindqvist, Anna K Överby
Viperin is an interferon (IFN)-stimulated gene product, which is part of the first line of the intracellular response against viral infection. It is a potent antiviral protein, strongly upregulated after IFN-stimulation and virus infection. Viperin is antivirally active against many different viruses from different families and has been shown to inhibit several flaviviruses. Flaviviruses are an important group of arthropod-borne viruses that cause millions of infections annually. In this review, we focus on the recent advances of the antiviral mechanisms of viperin against these flaviviruses, both pointing to similarities and differences between viruses within the same genera...
September 2018: DNA and Cell Biology
https://www.readbyqxmd.com/read/30052060/cyp24a1-inhibition-facilitates-the-antiproliferative-effect-of-1-25-oh-2-d-3-through-downregulation-of-the-wnt-%C3%AE-catenin-pathway-and-methylation-mediated-regulation-of-cyp24a1-in-colorectal-cancer-cells
#19
Hongyan Sun, Chengwei Jiang, Lele Cong, Nan Wu, Xue Wang, Miao Hao, Tie Liu, Lei Wang, Yi Liu, Xianling Cong
CYP24A1 is overexpressed in colorectal cancer, and the reason for the dysregulation of CYP24A1 in colorectal cancer is still unknown. In the present study, experiments were designed to test whether CYP24A1 inhibition facilitated the antiproliferative effect of 1,25(OH)2 D3 . In addition, the role of methylation in the regulation of CYP24A1 expression in human colorectal cancer was investigated. The expression of CYP24A1 in SW480 and Caco2 colorectal cancer cells was inhibited by RNAi. CYP24A1 inhibition significantly increased the antiproliferative effects of 1,25(OH)2 D3 in SW480 cells compared with 1,25(OH)2 D3 treatment alone (16...
September 2018: DNA and Cell Biology
https://www.readbyqxmd.com/read/30020817/long-noncoding-rna-gas5-suppresses-3t3-l1-cells-adipogenesis-through-mir-21a-5p-pten-signal-pathway
#20
Haifeng Liu, Huan Li, Long Jin, Guilin Li, Silu Hu, Chunyou Ning, Jiazhong Guo, Surong Shuai, Xuewei Li, Mingzhou Li
Emerging studies indicated that both long noncoding RNAs and micro-RNAs play crucial roles in the mediation of adipogenesis, which is closely linked to obesity-related diseases. However, the mechanisms of lncRNA-miRNAs coregulating in adipogenesis are still largely unknown. In this study, we determined that lncRNA growth arrest-specific 5 (GAS5) presented an opposite expression pattern with miR-21a-5p in 3T3-L1 adipocytes development. To explore the role of GAS5 in adipogenesis, pcDNA3.1-GAS5 expression vectors and GAS5-siRNAs were used to perform GAS5 overexpression and knockdown, respectively...
September 2018: DNA and Cell Biology
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