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DNA and Cell Biology

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https://www.readbyqxmd.com/read/29993274/the-association-between-vitamin-d-binding-protein-polymorphisms-and-vitamin-d-level-on-epilepsy-in-china
#1
Haidong Wang, Yujin Guo, Gongying Li, Ruining Xie, Zhimei Zhang, Wenxiu Han, Mengqi Yang, Dan Chen, Pei Jiang
Accumulating studies suggest the potential association between epilepsy and vitamin D (VD) in recent years. Vitamin D binding protein (VDBP) is the main VD carrier and can affect the availability of VD and its metabolites. Thus, this study aimed to investigate the association between VDBP polymorphisms and VD level on epilepsy. A total of 220 epilepsy patients and 210 health controls were enrolled and polymorphisms of VDBP (rs4588, rs7041, rs2298849, and rs2282679) genotype were detected using the PCR-ligase detection reaction method...
July 11, 2018: DNA and Cell Biology
https://www.readbyqxmd.com/read/29990439/association-between-polymorphisms-in-cmtm-family-genes-and-hepatocellular-carcinoma-in-guangxi-of-china
#2
Chunhua Bei, Chao Tan, Xiaonian Zhu, Zhigang Wang, Shengkui Tan
Polymorphisms in genes may affect its expression and alter individual susceptibility to cancer. In this study, we investigate associations between CMTM family gene polymorphisms and hepatocellular carcinoma (HCC) in a southern Chinese population. Ten selected single-nucleotide polymorphisms (SNPs) in CMTM family genes were genotyped in 315 HCC patients and 315 cancer-free controls using Sequenom MassARRAY platform and the associations of the selected SNPs with HCC risk were evaluated. We found individuals with the rs164207 AA genotypes had a significantly increased risk of HCC than those with CC genotypes (adjusted OR = 2...
July 10, 2018: DNA and Cell Biology
https://www.readbyqxmd.com/read/29969286/selective-actionable-and-druggable-protein-kinases-drive-the-progression-of-neuroendocrine-prostate-cancer
#3
Chao Lu, Yunkai Qie, Shenglai Liu, Changli Wu, Zhihong Zhang, Ranlu Liu, Kuo Yang, Hailong Hu, Yong Xu
Current clinical anti-androgen therapies in advanced prostate cancer (PCa) are driving an increased incidence of neuroendocrine prostate cancer (NEPC), a histological variant exhibiting reduced androgen receptor levels and expression of neuroendocrine markers. The mechanisms underlying the development of NEPC are poorly understood. A set of available data from a well-validated xenograft model of NEPC was used to analyze the exact role of protein kinase (PK) played in the development of NEPC. Fifty-four actionable and druggable PKs, mainly enriched in PI3K-Akt, mTOR, and MAPK signaling pathways, were screened out from the drastically changed PKs during NEPC transdifferentiation...
July 3, 2018: DNA and Cell Biology
https://www.readbyqxmd.com/read/29969282/a-comparative-study-on-anti-invasion-antimigration-and-antiadhesion-effects-of-the-bioactive-carotenoids-of-saffron-on-4t1-breast-cancer-cells-through-their-effects-on-wnt-%C3%AE-catenin-pathway-genes
#4
Laleh Arzi, Gholamhossein Riazi, Majid Sadeghizadeh, Reyhane Hoshyar, Nazli Jafarzadeh
Crocus sativus L. (saffron) has been used as a spice and as a medicine for the past four thousand years. Recently, saffron has been well documented to possess anticancer effects on primary tumors. However studies of its antimetastatic potential are lacking. The present study is a comparative investigation of the antimetastatic effects of saffron carotenoids, crocin and crocetin, on triple negative metastatic breast cancer cells (4T1) and their effects on the Wnt/β-catenin pathway. It was found that treatment of 4T1 cells with crocin and crocetin resulted in the inhibition of viability in a dose-dependent manner...
July 3, 2018: DNA and Cell Biology
https://www.readbyqxmd.com/read/29958005/resveratrol-reverts-epigenetic-and-transcription-changes-caused-by-smoke-inhalation-on-bone-related-genes-in-rats
#5
Aladim Gomes Lameira, Beatriz Ganhito Françoso, Samir Absy, Vanessa Galego Pecorari, Marcio Zafalon Casati, Fernanda Vieira Ribeiro, Denise Carleto Andia
We investigated the effects of cigarette smoke (CS) and resveratrol intake on the modulation of bone repair-related genes through epigenetic mechanisms at the global and gene-specific levels, after 30 days of calvarial defects were created, in rats. The samples were assigned to three groups as follows: no CS, CS, and CS/resveratrol. After evaluation of global (5 hmC) changes and epigenetic and transcription regulation at gene-specific levels, CS group showed increased 5 hmC and Tets transcripts with demethylation at Rankl and Trap promoters (p ≤ 0...
June 29, 2018: DNA and Cell Biology
https://www.readbyqxmd.com/read/29957029/the-combining-effects-of-cell-free-circulating-tumor-dna-of-breast-tumor-to-the-noninvasive-prenatal-testing-results-a-simulating-investigation
#6
Ya-Hong Cai, Guang-Yu Yao, Lu-Jia Chen, Hai-Yan Gan, Chang-Sheng Ye, Xue-Xi Yang
Massively parallel sequencing of circulating fetal DNA in the plasma of pregnant women is a common method for noninvasive prenatal testing (NIPT) of fetal trisomy 13, 18, and 21. However, circulating DNA is not restricted to pregnant women, with increased levels of plasma DNA also frequently detected in the plasma of cancer patients. Among pregnant women whose NIPT results were inconsistent with the fetal karyotype, a small number of patients have subsequently been diagnosed with a previously undetected malignancy...
June 29, 2018: DNA and Cell Biology
https://www.readbyqxmd.com/read/29927618/sertoli-cells-engineered-to-express-insulin-to-lower-blood-glucose-in-diabetic-mice
#7
Gurvinder Kaur, Lea Ann Thompson, Rachel L Babcock, Karl Mueller, Jannette M Dufour
Long-term survival of allo- and xenotransplanted immune-privileged Sertoli cells (SCs) is well documented suggesting that SCs can be used to deliver foreign proteins for cell-based gene therapy. The aim of this study was to use a lentivirus carrying proinsulin cDNA to achieve stable expression and lowering of blood glucose levels (BGLs). A SC line transduced with the lentivirus (MSC-LV-mI) maintained stable insulin expression in vitro. These MSC-LV-mI cells were transplanted and grafts were analyzed for cell survival, continued proinsulin mRNA, and insulin protein expression...
June 21, 2018: DNA and Cell Biology
https://www.readbyqxmd.com/read/29905492/lrhmgb1-shares-structural-similarities-with-human-hmgb1-and-its-expression-is-induced-in-bacterial-infection-antiviral-vaccination-and-pathogen-associated-molecular-patterns-stimulation
#8
Saswati S Lenka, Mahismita Paichha, Madhubanti Basu, Mrinal Samanta
The high-mobility group box 1 (HMGB1) protein is a highly conserved nonhistone chromosomal protein ubiquitously present in almost all cell types. In the nucleus, it facilitates DNA repair and replication, V(D)J recombination, stabilization of nucleosome, and in the cytoplasm, it regulates autophagy and apoptosis. In addition to these intracellular functions, HMGB1 also facilitates activation of innate immune responses and plays key roles in host defense. To investigate its role in fish, we cloned and characterized HMGB1 in Labeo rohita (LrHMGB1), the most important freshwater fish species in the Indian subcontinent...
June 15, 2018: DNA and Cell Biology
https://www.readbyqxmd.com/read/29902078/leukemia-inhibitory-factor-receptor-suppresses-the-metastasis-of-clear-cell-renal-cell-carcinoma-through-negative-regulation-of-the-yes-associated-protein
#9
Chengyong Lei, Shidong Lv, Hongyi Wang, Chuan Liu, Qiliang Zhai, Shanci Wang, Guixing Cai, Dingheng Lu, Zhen Sun, Qiang Wei
The role of leukemia inhibitory factor receptor (LIFR), which is important in the signal transduction of the interleukin-6 cytokine family, is still undefined in clear cell renal cell carcinoma (ccRCC). Thus, we examined the function and mechanism of LIFR in ccRCC. Low LIFR expression correlated with a poor prognosis and an aggressive tumor phenotype. Moreover, integrated LIFR DNA and mRNA analysis revealed that promoter methylation and copy number variation contributed to the reduced LIFR expression. LIFR knockdown increased 786-O and Caki-2 cell invasion and migration...
June 14, 2018: DNA and Cell Biology
https://www.readbyqxmd.com/read/29897788/zinc-a-potential-antiviral-against-hepatitis-e-virus-infection
#10
Nidhi Kaushik, Saumya Anang, Krishna Priya Ganti, Milan Surjit
Hepatitis E virus (HEV) is a major cause of viral hepatitis worldwide. Owing to its feco oral transmission route, sporadic as well as epidemic outbreaks recurrently occur. No specific antiviral therapy is available against the disease caused by HEV. Broad spectrum antivirals such as ribavirin and interferon alfa are prescribed in severe and chronic HEV cases. However, the side effects, cost, and limitations of usage render the available treatment unsuitable for several categories of patients. We recently reported the ability of zinc to inhibit viral replication in mammalian cell culture models of HEV infection...
June 13, 2018: DNA and Cell Biology
https://www.readbyqxmd.com/read/29889555/genetic-variation-in-the-h19-igf2-cluster-might-confer-risk-of-developing-impaired-renal-function
#11
Eliecer Coto, Carmen Díaz Corte, Salvador Tranche, Juan Gómez, Julián R Reguero, Belén Alonso, Sara Iglesias, Helena Gil-Peña, Xueqian Yin, Pablo Coto-Segura
The H19-IGF2 imprinted gene region could be implicated in the risk of developing impaired renal function (IRF). Our aim was to determine the association of several common H19-IGF2 variants and IRF in a cohort of elderly healthy individuals. The study involved 675 individuals >65 years of age, 184 with type 2 diabetes mellitus (T2DM), and 105 with IRF (estimated glomerular filtration rate [eGFR] <60). They were genotyped for two common H19 single nucleotide polymorphisms (SNPs) (rs2839698 and rs10732516), one H19-IGF2 intergenic indel (rs201858505), and one indel in the 3'UTR of the IGF2...
June 11, 2018: DNA and Cell Biology
https://www.readbyqxmd.com/read/29878850/association-between-four-polymorphisms-in-lncrna-and-risk-of-lung-cancer-in-a-chinese-never-smoking-female-population
#12
Min Gao, Hang Li, Xiaoting Lv, Baosen Zhou, Zhihua Yin
Long noncoding RNAs (lncRNAs) play important roles in the development of human cancers. This is the first case-control study of the association between specific polymorphisms in lncRNA genes and the risk of lung cancer, as well as the gene-environment interaction between the polymorphisms and cooking oil fume exposure in Chinese never-smoking females. A hospital-based case-control study was carried out in Shenyang, Liaoning province. The study included 395 cases and 556 controls. The polymorphisms of rs4785367, rs3803662, rs10750417, and rs1814343 in lncRNA genes were analyzed...
June 7, 2018: DNA and Cell Biology
https://www.readbyqxmd.com/read/29792527/enteric-neural-stem-cells-expressing-insulin-like-growth-factor-1-a-novel-cellular-therapy-for-hirschsprung-s-disease-in-mouse-model
#13
Wei Liu, Lijuan Zhang, Rongde Wu
Transplanting enteric neural stem cells (ENSCs) is an innovative approach for replacing enteric neurons in Hirschsprung's disease (HSCR). However, posttransplantation cell survival and differentiation limit efficacy. We aimed to investigate whether transplantation of ENSCs engineered with insulin-like growth factor 1 (IGF-1) could improve survival and differentiation of the engrafted cells and promote functional recovery of the aganglionic colon. ENSCs were isolated from the intestine of neonatal mice and genetically modified to express IGF-1...
May 24, 2018: DNA and Cell Biology
https://www.readbyqxmd.com/read/29756997/arg1-gene-polymorphisms-and-their-association-in-individuals-with-essential-hypertension-a-case-control-study
#14
Syed Fawad Ali Shah, Tahir Iqbal, Raheel Qamar, Muhammad Arshad Rafiq, Sabir Hussain
The purpose of this study is to investigate the association of variant alleles (rs2781666 and rs2781667) at ARG1 to be involved in the generation of essential hypertension (EH) phenotypes in human subjects. The ARG1 noncoding polymorphisms (rs2781666; Chr6:131572419-G/T and rs2781667; Chr6:131573754-C/T) were investigated in 570 subjects, including 285 individuals diagnosed with EH. Determination of serum arginase activity and concentrations of nitric oxide catabolites were detected by the colorimetric enzymatic assay...
May 14, 2018: DNA and Cell Biology
https://www.readbyqxmd.com/read/29746152/toxic-effect-of-cadmium-lead-and-arsenic-on-the-sertoli-cell-mechanisms-of-damage-involved
#15
Juan Ramos-Treviño, Susana Bassol-Mayagoitia, José Anselmo Hernández-Ibarra, Pablo Ruiz-Flores, Martha P Nava-Hernández
Over the past decades, an increase has been described in exposure to environmental toxins; consequently, a series of studies has been carried out with the aim of identifying problems associated with health. One of the main risk factors is exposure to heavy metals. The adverse effects that these compounds exert on health are quite complex and difficult to elucidate, in that they act at different levels and there are various signaling pathways that are implicated in the mechanisms of damage. The Sertoli cells plays a role of vital importance during the process of spermatogenesis, and it has been identified as one of the principal targets of heavy metals...
May 10, 2018: DNA and Cell Biology
https://www.readbyqxmd.com/read/29874113/rs2303428-of-msh2-is-associated-with-hepatocellular-carcinoma-prognosis-in-a-chinese-population
#16
Xiaonian Zhu, Zhigang Wang, Xiaoqiang Qiu, Weiwei Wang, Chunhua Bei, Chao Tan, Linyuan Qin, Yuan Ren, Shengkui Tan
The defects of DNA repair genes may lead to genomic instability and cancer. As an important DNA mismatch repair gene that maintains genomic stability from DNA replication errors, genetic variants of mutS homolog 2 (MSH2) are associated with some cancers. In this study, 1021 hepatocellular carcinoma (HCC) cases and 1021 non-HCC controls from Guangxi were included to explore the association between MSH2 single-nucleotide polymorphisms (SNPs) and HCC. Among the eight MSH2 SNPs, only genotype distribution of rs2303428 was significantly different from HCC and non-HCC patients (p < 0...
July 2018: DNA and Cell Biology
https://www.readbyqxmd.com/read/29756996/twsg1-is-a-novel-tumor-suppressor-in-gastric-cancer
#17
Jingyi Yuan, Jiali Zeng, Chun Shuai, Yue Liu
Gastric cancer has a high incidence and mortality in the world, especially in China. The pathogenesis leading to the high heterogeneity of gastric cancer remains unclear. It is believed that TWSG1 is associated with a variety of tumors, but there are few studies related to gastric cancer. To investigate the biological significance of TWSG1, we evaluated the TWSG1 expression of the clinical samples and gastric cancer cell lines (BGC-823, MGC-803, and SGC-790) via stomach cancer tissue array, real-time PCR, and western blotting...
June 2018: DNA and Cell Biology
https://www.readbyqxmd.com/read/29750542/the-critical-clinical-role-of-interferon-beta-in-regulating-cancer-stem-cell-properties-in-triple-negative-breast-cancer
#18
Mary R Doherty, Mark W Jackson
Triple-negative breast cancer (TNBC) the deadliest form of this disease currently lacks a targeted therapy and is characterized by increased risk of metastasis and presence of therapeutically resistant cancer stem cells (CSC). Recent evidence has demonstrated that the presence of an interferon (IFN)/signal transducer of activated transcription 1 (STAT1) gene signature correlates with improved therapeutic response and overall survival in TNBC patients. In agreement with these clinical observations, our recent work has demonstrated, in a cell model of TNBC that CSC have intrinsically repressed IFN signaling...
June 2018: DNA and Cell Biology
https://www.readbyqxmd.com/read/29683332/the-impact-of-fshr-gene-polymorphisms-ala307thr-and-asn680ser-in-the-endometriosis-development
#19
Gustavo Mendonça André, Camila Martins Trevisan, Isabela Nacione Pedruzzi, Ramon Felix Martins Fernandes, Renato Oliveira, Denise Maria Christofolini, Bianca Bianco, Caio Parente Barbosa
Endometriosis is an estrogen-dependent inflammatory disease that affects a large number of women in reproductive age. Follicle-stimulating hormone (FSH) plays a role in steroidogenesis and acts through a transmembrane glycoprotein, FSH receptor (FSHR). Polymorphisms in FSHR gene were previously associated with variability in FSH serum level and reproductive outcomes, but its relation with endometriosis has not been clarified and demonstrated conflicting results, ranging from strong links to no association to endometriosis...
June 2018: DNA and Cell Biology
https://www.readbyqxmd.com/read/29672161/tissue-expression-analysis-and-characterization-of-smad3-promoter-in-bovine-myoblasts-and-preadipocytes
#20
Le Zhang, Yue Ning, Peiwei Li, Hongfang Guo, Linsen Zan
The transforming growth factor-β (TGFβ) pathway plays many key roles in regulating numerous biological processes. In addition, the effects of TGFβ are mediated by the transcription factor Smad3. However, the regulation of Smad3 activity is not well understood. In the present study, quantitative real-time PCR revealed that the Smad3 gene was expressed ubiquitously in 11 bovine tissues and displayed different expression patterns between muscle and adipose tissue. We further explored the expression and regulation of Smad3 gene by cloning the bovine Smad3 gene promoter; a dual-luciferase reporter assay identified that the core promoter region -337 to -41 bp was located in a CpG island...
June 2018: DNA and Cell Biology
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