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DNA and Cell Biology

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https://www.readbyqxmd.com/read/28191864/overexpression-of-nad-p-h-quinone-oxidoreductase-1-inhibits-hepatocellular-carcinoma-cell-proliferation-and-induced-apoptosis-by-activating-ampk-pgc-1%C3%AE-pathway
#1
Xin Zhang, Kun Han, Dong-Hong Yuan, Cun-Ying Meng
Hepatocellular carcinoma (HCC) is the most common lethal malignancy and a leading cause of malignancy-associated death in many countries, but mainly in Asia. Expression of the NAD(P)H:quinone oxidoreductase 1 (NQO1) protein is involved in the growth of various human cancers, including HCC. NQO1 is considered an inhibitor of cancers. The present study aimed to investigate the function and mechanism of NQO1 in HCC. In this study, we found that NQO1 overexpression decreased HCC cell SK-hep-1 and Hep3B cell proliferation and induced apoptosis...
February 13, 2017: DNA and Cell Biology
https://www.readbyqxmd.com/read/28177658/the-role-of-exosomal-vp40-in-ebola-virus-disease
#2
Michelle L Pleet, Catherine DeMarino, Benjamin Lepene, M Javad Aman, Fatah Kashanchi
Ebola virus (EBOV) can cause a devastating hemorrhagic disease, leading to death in a short period of time. After infection, the resulting EBOV disease results in high levels of circulating cytokines, endothelial dysfunction, coagulopathy, and bystander lymphocyte apoptosis in humans and nonhuman primates. The VP40 matrix protein of EBOV is essential for viral assembly and budding from the host cell. Recent data have shown that VP40 exists in the extracellular environment, including in exosomes, and exosomal VP40 can impact the viability of recipient immune cells, including myeloid and T cells, through the regulation of the RNAi and endosomal sorting complexes required for transport pathways...
February 8, 2017: DNA and Cell Biology
https://www.readbyqxmd.com/read/28157400/nuclear-factor-of-%C3%AE%C2%BAb1-is-a-key-regulator-for-the-transcriptional-activation-of-milk-synthesis-in-bovine-mammary-epithelial-cells
#3
Xin Huang, Yanli Zang, Minghui Zhang, Xiaohan Yuan, Meng Li, Xuejun Gao
The nuclear factor of κB (NFκB) family has been well known for its significant role in regulating the expression of numerous genes that control many biological processes. However, it is unclear whether NFκB could regulate milk synthesis. In this study, we identified NFκB1 as a critical regulator for milk synthesis in bovine mammary epithelial cells (BMECs). Gene function study revealed that NFκB1 modulates the expression of mammalian target of rapamycin (mTOR), sterol response element-binding protein (SREBP)-1c, and β4Gal-T2 for milk synthesis...
February 3, 2017: DNA and Cell Biology
https://www.readbyqxmd.com/read/28157399/cxcr5-cd8-t-cells-indirectly-offer-b-cell-help-and-are-inversely-correlated-with-viral-load-in-chronic-hepatitis-b-infection
#4
Hang Jiang, Linhai Li, Jiang Han, Zhiwei Sun, Yihui Rong, Yun Jin
Treatment options for chronic hepatitis B (CHB) infection are extremely limited. CXCR5(+) CD8(+) T cell is a novel cell subtype and could possess strong cytotoxic properties in HIV infection. In this study, we investigated the role of CXCR5(+) CD8(+) T cells in CHB patients. Compared to healthy individuals, both CHB patients and hepatitis B virus (HBV)-infected hepatocellular carcinoma patients presented significant upregulation of CXCR5(+) CD8(+) T cells in peripheral blood, in which CXCR5(+) CD8(+) T cells were negatively correlated with the frequency of CXCR5(+) CD4(+) T cells in CHB patients...
February 3, 2017: DNA and Cell Biology
https://www.readbyqxmd.com/read/28157396/notch-signaling-modulates-the-balance-of-regulatory-t-cells-and-t-helper-17-cells-in-patients-with-chronic-hepatitis-c
#5
Lei Qin, Yan-Cai Zhou, Hong-Jie Wu, Ya Zhuo, Yan-Ping Wang, Chang-Yun Si, Yong-Mei Qin
The imbalance of regulatory T cells (Tregs) and T helper 17 (Th17) cells contributes to the persistent hepatitis C virus (HCV) infection. However, modulatory factors associated with Tregs-Th17 balance were not fully elucidated. A recent study demonstrated an immunoregulatory strategy by inactivation of Notch signaling to reverse the disequilibrium of Tregs-Th17 cells in immune thrombocytopenia. Thus, the aim of this study was to assess the effect of Notch signaling in regulating the functions of Tregs and Th17 cells in chronic hepatitis C...
February 3, 2017: DNA and Cell Biology
https://www.readbyqxmd.com/read/28151018/calcium-dobesilate-prevents-diabetic-kidney-disease-by-decreasing-bim-and-inhibiting-apoptosis-of-renal-proximal-tubular-epithelial-cells
#6
Tian Cai, Xiao-Yun Wu, Xiao-Qian Zhang, Hong-Xia Shang, Zhong-Wen Zhang, Jian-Jun Dong, Lin Liao
Apoptosis of renal proximal tubular epithelial cells (PTECs) plays a vital role in the pathogenesis and progression of diabetic kidney disease (DKD). Calcium dobesilate is a vascular protective compound used for treatment of diabetic retinopathy and chronic venous insufficiency. The aim of this study was to determine whether calcium dobesilate can protect PTECs from glucose-induced apoptosis and the potential mechanism of this effect. It is indicated that high glucose promoted abnormal apoptosis of HK2 cells, which was inhibited by treatment of calcium dobesilate, while Bim expression decreased in response to calcium dobesilate in high-glucose-treated HK2 cells...
February 2, 2017: DNA and Cell Biology
https://www.readbyqxmd.com/read/28151013/sex-determining-region-y-box-2-promotes-growth-of-lung-squamous-cell-carcinoma-and-directly-targets-cyclin-d1
#7
Chiguan Li, Bingwen He, Cuiping Huang, Huaping Yang, Liming Cao, Jun Huang, Chengping Hu
Sex-determining region Y-box 2 (SOX2) is an oncogene known to be amplified and overexpressed in various human malignancies, including lung squamous cell carcinoma (SCC). However, the role played by SOX2 in lung SCC development remains to be elucidated. We measured the levels of SOX2 and cyclin D1 mRNA and protein expression in lung SCC tissues and a lung SCC cell line, and found that both levels were dramatically upregulated in specimens of lung SCC tissue when compared with their expression levels in samples of adjacent nonneoplastic tissue...
February 2, 2017: DNA and Cell Biology
https://www.readbyqxmd.com/read/28112546/characteristics-and-roles-of-exosomes-in-cardiovascular-disease
#8
Yuan Zhang, Yan-Wei Hu, Lei Zheng, Qian Wang
Exosomes are nano-sized biological membrane-enclosed vesicles that contain a cell-specific cargo of proteins, lipids, and nucleic acids that are released and taken up by most cell types, thereby inducing expression and functional changes via horizontal transfer of cargos between cells. Thus, exosomes present a largely unknown "cell-to-cell" communication system, which is now increasingly being investigated for diagnostic and therapeutic use in cardiovascular disease (CVD). The purpose of this review is to summarize recent findings on the properties and roles of exosomes in a variety of physiological and pathological settings related to CVD...
January 23, 2017: DNA and Cell Biology
https://www.readbyqxmd.com/read/28092463/ccaat-enhancer-binding-protein-%C3%AE-mediates-the-killing-of-toxoplasma-gondii-by-inducing-autophagy-in-nonhematopoietic-cells
#9
Yanhui Yu, Na Zhao, Jiaqi An, Xichen Zhang
Autophagy is a main defense strategy by which infected host cells can virtually induce the killing of parasite, including Toxoplasma gondii. However, the regulatory mechanisms of autophagy in T. gondii-infected nonhematopoietic cells are still unknown. Emerging evidence indicates that CCAAT/enhancer-binding protein β (C/EBP β) is associated with the regulation of autophagy. Herein, we hypothesized that C/EBP β plays roles in inducing autophagy in nonhematopoietic cells. Expression of C/EBP β was aberrantly regulated in endothelial cells and retinal pigment epithelial cells challenged by T...
January 16, 2017: DNA and Cell Biology
https://www.readbyqxmd.com/read/28085489/microrna-130a-promotes-human-keratinocyte-viability-and-migration-and-inhibits-apoptosis-through-direct-regulation-of-stk40-mediated-nf-%C3%AE%C2%BAb-pathway-and-indirect-regulation-of-sox9-meditated-jnk-mapk-pathway-a-potential-role-in-psoriasis
#10
Ying Xiong, Hongxiao Chen, Liqian Liu, Leihong Lu, Zongshan Wang, Fujun Tian, Yongliang Zhao
Psoriasis is a chronic inflammatory skin disorder. The aim of this study was to determine a potential role of microRNA (miR)-130a in psoriasis, and underlying mechanism. Expression levels of miR-130a in psoriasis specimens and normal skin tissues were analyzed. MiR-130a mimic, inhibitor, miR-control, small interfering RNA (siRNA) specific serine/threonine kinase 40 (STK40), or sex-determining region Y chromosome-box 9 (SOX9) were transfected to human keratinocyte HaCaT cells, respectively. After transfection, the cell viability, apoptosis, and migration were determined...
January 13, 2017: DNA and Cell Biology
https://www.readbyqxmd.com/read/28080131/hypusination-of-eif5a-as-a-target-for-antiviral-therapy
#11
Michelle E Olsen, John H Connor
No abstract text is available yet for this article.
January 12, 2017: DNA and Cell Biology
https://www.readbyqxmd.com/read/28055236/characterization-of-vntrs-within-the-entire-region-of-slc6a3-and-its-association-with-hypertension
#12
Won-Tae Kim, Se-Ra Lee, Yun-Gil Roh, Seung Il Kim, Yung Hyun Choi, Mi-Hye Mun, Mi-So Jeong, Sang Seok Koh, Sun-Hee Leem
The dopamine transporter SLC6A3 (DAT1) mediates uptake of dopamine into presynaptic terminals. In addition, in previous reports, hypertensive rats were associated with DAT gene, but the genetic association with SLC6A3 and hypertension is still unknown. We examined the distribution of variable number of tandem repeats (VNTRs) and conducted polymorphic analysis of the entire region of SLC6A3. Ten VNTR regions (MS1-10) were revealed throughout the intronic and UTRs; seven VNTR regions were newly isolated and three VNTRs were previously reported...
January 5, 2017: DNA and Cell Biology
https://www.readbyqxmd.com/read/28051330/g-protein-alpha-s-subunit-promotes-cell-proliferation-of-renal-cell-carcinoma-with-involvement-of-protein-kinase-a-signaling
#13
Bo Zhang, Nan Sun, Xin Mu, Lei Zhi, Lei Zhai, Yuan Jiang, Zheng Fu, Zhi Yao
Heterotrimeric G proteins, which are composed of Gα and Gβγ subunits, transduce signals sensed by the coupled surface receptors. Aberrant expressions of G proteins have been observed in many cancer types. This study aimed to determine the expression level of the stimulatory G protein alpha S subunit (Gαs, the main transcript encoded by the GNAS locus) and its biological function in renal cell carcinoma (RCC). Western blotting and quantitative reverse transcription-PCR results show that Gαs expression dramatically increased in RCC cell lines (ACHN, GRC-1, and 786-O) compared to normal renal epithelial cells HK-2...
January 4, 2017: DNA and Cell Biology
https://www.readbyqxmd.com/read/28112987/photoprotective-potential-of-glycolic-acid-by-reducing-nlrc4-and-aim2-inflammasome-complex-proteins-in-uvb-radiation-induced-normal-human-epidermal-keratinocytes-and-mice
#14
Sung-Jen Hung, Sheau-Chung Tang, Pei-Yun Liao, Jheng-Siang Ge, Yu-Ping Hsiao, Jen-Hung Yang
Exposure to UVB radiation induces inflammation and free radical-mediated oxidative stress through reactive oxygen species (ROS) that play a crucial role in the induction of skin cancer. Glycolic acid (GA) is frequently used in cosmetics and dermatology. The aim of the study was to analyze the photoprotective mechanisms through which GA retards UVB-induced ROS accumulation and inflammation in normal human epidermal keratinocytes (NHEKs) and mice skin, respectively. NHEK cell line and C57BL/6J mice were treated with GA (0...
February 2017: DNA and Cell Biology
https://www.readbyqxmd.com/read/28112986/acknowledgment-of-our-reviewers
#15
(no author information available yet)
No abstract text is available yet for this article.
February 2017: DNA and Cell Biology
https://www.readbyqxmd.com/read/28075173/tgf%C3%AE-1-induced-lncrna-uca1-upregulation-promotes-gastric-cancer-invasion-and-migration
#16
Zhong-Kun Zuo, Yi Gong, Xiang-Heng Chen, Fei Ye, Zheng-Ming Yin, Qian-Ni Gong, Jiang-Sheng Huang
According to recent studies, long noncoding RNA urothelial carcinoma associated 1 (UCA1) is involved in the development and progression of many malignant tumors, including gastric cancer (GC). We validated the detailed role of UCA1 in human GC cell lines and GC tissues so as to determine its exact function and the underlying mechanism of GC invasion and migration. In our research, lncRNA-UCA1 was specifically upregulated in GC tissues and cell lines, and augmented GC cell proliferation, and invasive and migratory capabilities...
February 2017: DNA and Cell Biology
https://www.readbyqxmd.com/read/28060535/circulating-micrornas-promising-biomarkers-involved-in-several-cancers-and-other-diseases
#17
REVIEW
Yicheng Zhao, Yuanyuan Song, Li Yao, Guangqi Song, Chunbo Teng
Recently, many studies indicated that microRNAs (miRNAs) stably existed in various body fluids, including serum, plasma, saliva, and urine. Such miRNAs that exist in mammalian body fluids are known as circulating miRNAs, and they can transmit signals between cells and regulate intracellular gene expression. Currently, we barely understand the characteristics, sources, secretion, uptake, and functions of newly generated miRNAs. Particularly, it has been shown that certain types of circulating miRNAs can provide effective clinical data, suggesting their roles as novel biomarkers for the early detection of diseases such as cancers, cardiovascular diseases, and diabetes...
February 2017: DNA and Cell Biology
https://www.readbyqxmd.com/read/28055232/biological-features-of-a-renal-cell-carcinoma-cell-line-derived-from-spinal-metastasis
#18
Zhenhua Zhou, Yan Li, Huiqing Wang, Xudong Wang, Jianru Xiao
The establishment of a metastatic renal cell carcinoma (mRCC) cell line can facilitate the search for molecular mechanisms involved in RCC metastasis. A novel human mRCC cell line, designated RCC96, was established from an mRCC of the spine from a 65-year-old Chinese man. Morphology, cell cycle phase, chromosome number, cell capability of migration, tumorigenicity in nude mice, and cytogenetic features of RCC96 were investigated. Cell growth curve was detected and the cell number doubling time was 52 h. Karyotype analysis showed that these cells were polyploidy...
February 2017: DNA and Cell Biology
https://www.readbyqxmd.com/read/28005398/the-paracrine-effect-of-degenerated-disc-cells-on-healthy-human-nucleus-pulposus-cells-is-mediated-by-mapk-and-nf-%C3%AE%C2%BAb-pathways-and-can-be-reduced-by-tgf-%C3%AE-1
#19
Feng Cai, Lei Zhu, Feng Wang, Rui Shi, Xin-Hui Xie, Xin Hong, Xiao-Hu Wang, Xiao-Tao Wu
Inflammation is thought to have a major role in the pathogenesis of disc degeneration. Studies have shown that nucleus pulposus cells (NPCs) respond to one or two specific cytokines by regulating cell proliferation or matrix synthesis. However, the effects of a cocktail of factors secreted by degenerated disc cells on transplanted exogenous healthy NPCs remain unknown. Concentrations of multiple cytokines in degenerated disc tissue-conditioned medium (dCM) were measured using enzyme-linked immunosorbent assay (ELISA)...
February 2017: DNA and Cell Biology
https://www.readbyqxmd.com/read/28004979/epigenetic-silencing-of-the-human-18%C3%A2-kda-translocator-protein-in-a-t-cell-leukemia-cell-line
#20
Ryan J Middleton, Winnie Wai-Ying Kam, Guo-Jun Liu, Richard B Banati
The mitochondrial membrane 18 kDa translocator protein (TSPO), previously known as the peripheral benzodiazepine receptor, is constitutively expressed in most organs, most abundantly in hormonal tissue and cells of mononuclear phagocyte lineage, while in the brain, TSPO expression is induced in the wake of injury, inflammation, and neurodegeneration. Increased TSPO expression is also prominent in several cancerous tissues where it appears to correlate with the degree of malignancy. Currently, TSPO is thus actively investigated as a generic biomarker for disease activity and a therapeutic target for a wide range of diseases...
February 2017: DNA and Cell Biology
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