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European Journal of Internal Medicine

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https://www.readbyqxmd.com/read/29336868/the-therapeutic-potential-of-targeting-the-peripheral-endocannabinoid-cb1-receptor-system
#1
REVIEW
Joseph Tam, Liad Hinden, Adi Drori, Shiran Udi, Shahar Azar, Saja Baraghithy
Endocannabinoids (eCBs) are internal lipid mediators recognized by the cannabinoid-1 and -2 receptors (CB1R and CB2R, respectively), which also mediate the different physiological effects of marijuana. The endocannabinoid system, consisting of eCBs, their receptors, and the enzymes involved in their biosynthesis and degradation, is present in a vast number of peripheral organs. In this review we describe the role of the eCB/CB1R system in modulating the metabolism in several peripheral organs. We assess how eCBs, via activating the CB1R, contribute to obesity and regulate food intake...
January 11, 2018: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/29336867/nevus-like-lesions-on-the-lip-and-the-foot
#2
Nilufer Ozdemir Kutbay, Banu Sarer Yurekli, Ahmet Sever, Can Ceylan
No abstract text is available yet for this article.
January 11, 2018: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/29329891/medical-use-of-cannabis-and-cannabinoids-containing-products-regulations-in-europe-and-north-america
#3
REVIEW
Ran Abuhasira, Liat Shbiro, Yuval Landschaft
In 1937, the United States of America criminalized the use of cannabis and as a result its use decreased rapidly. In recent decades, there is a growing interest in the wide range of medical uses of cannabis and its constituents; however, the laws and regulations are substantially different between countries. Laws differentiate between raw herbal cannabis, cannabis extracts, and cannabinoid-based medicines. Both the European Medicines Agency (EMA) and the United States Food and Drug Administration (FDA) do not approve the use of herbal cannabis or its extracts...
January 10, 2018: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/29329893/effect-of-short-and-long-term-diabetes-control-on-in-hospital-and-one-year-mortality-rates-in-hospitalized-patients-with-diabetic-foot
#4
Z Feldbrin, M Shargorodsky, J Wainstein, D Melnikov, G Zandman-Goddard
INTRODUCTION: It remains unclear whether diabetic patients with diabetic foot complications benefit from strict glycemic control during hospitalization The present study investigates the effect of short- and long-term diabetes control on hospital outcomes including: in-hospital and one year mortality rates, length of hospital stay and the rate of repeated admissions. METHODS: Type 2 diabetic patients (n = 341) were hospitalized for diabetic foot complications at Wolfson Medical Center over a 5 year period (2008-2012)...
January 9, 2018: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/29329892/pressure-to-publish-in-the-biomedical-scientific-field-ethical-conflicts-or-a-possible-obsessive-compulsive-disorder
#5
LETTER
Salvatore Chirumbolo, Geir Bjørklund
No abstract text is available yet for this article.
January 9, 2018: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/29325793/mucocutaneous-hyperpigmentation
#6
Francisco Galeano-Valle, Lucía Higuera-Cabañes
No abstract text is available yet for this article.
January 8, 2018: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/29325792/chronic-obstructive-pulmonary-disease-and-community-acquired-pneumonia-additional-studies-are-required
#7
LETTER
Javier de Miguel-Díez, Ana López-de-Andrés, Valentín Hernández-Barrera, Isabel Jiménez-Trujillo, Manuel Méndez-Bailón, José María de Miguel-Yanes, Rodrigo Jiménez-García
No abstract text is available yet for this article.
January 8, 2018: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/29325791/the-therapeutic-effects-of-cannabis-and-cannabinoids-an-update-from-the-national-academies-of-sciences-engineering-and-medicine-report
#8
REVIEW
Donald I Abrams
The National Academies of Sciences, Engineering and Medicine conducted a rapid turn-around comprehensive review of recent medical literature on The Health Effects of Cannabis and Cannabinoids. The 16-member committee adopted the key features of a systematic review process, conducting an extensive search of relevant databases and considered 10,000 recent abstracts to determine their relevance. Primacy was given to recently published systematic reviews and primary research that studied one of the committee's 11 prioritized health endpoints- therapeutic effects; cancer incidence; cardiometabolic risk; respiratory disease; immune function; injury and death; prenatal, perinatal and postnatal outcomes; psychosocial outcomes; mental health; problem Cannabis use; and Cannabis use and abuse of other substances...
January 8, 2018: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/29317139/female-gender-and-mortality-risk-in-decompensated-heart-failure
#9
Domenico Scrutinio, Pietro Guida, Andrea Passantino, Rocco Lagioia, Rosa Raimondo, Mario Venezia, Enrico Ammirati, Fabrizio Oliva, Miriam Stucchi, Maria Frigerio
BACKGROUND: Still there is conflicting evidence about gender-related differences in prognosis among patients with heart failure. This prognostic uncertainty may have implications for risk stratification and planning management strategy. The aim of the present study was to explore the association between gender and one-year mortality in patients admitted with acute decompensated heart failure (ADHF). METHODS: We studied 1513 patients. The Cumulative Incidence Function (CIF) method was used to estimate the absolute rate of mortality, heart transplantation (HT)/ventricular assist device (VAD) implantation, and survival free of HT/VAD implantation at 1year...
January 6, 2018: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/29310996/appropriateness-of-statin-prescription-in-the-elderly
#10
M Ruscica, C Macchi, C Pavanello, A Corsini, A Sahebkar, C R Sirtori
Statins, the most widely used drugs in the Western world, have become a pivotal component in the primary and secondary prevention of vascular diseases. Although benefits have been well documented in younger-than-75-year-old individuals, the value of statins in people aged >75years and over is controversial. The CTT meta-analysis calculated an absolute risk reduction of 0.6%/year per 38.7mg/dl reduction in LDL-C levels in patients aged >75years, that would translate into a number needed to treat of 167...
January 5, 2018: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/29310995/a-red-eye-and-a-brown-back-there-s-no-smoke-without-a-fire
#11
H E Dorien van Dongen, Daan J L van Twist
No abstract text is available yet for this article.
January 5, 2018: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/29310994/peripheral-arterial-disease-is-associated-with-higher-mortality-in-patients-with-incident-acute-myocardial-infarction
#12
Lisa Dinser, Christa Meisinger, Ute Amann, Margit Heier, Christian Thilo, Bernhard Kuch, Annette Peters, Inge Kirchberger
BACKGROUND: Little data is available on short- and long-term survival in patients with peripheral arterial disease (PAD) after acute myocardial infarction (AMI). We aimed to examine the association of PAD and 28-day case fatality as well as long-term mortality in a population-based sample of patients with incident AMI. METHODS: In this secondary analysis of data from the German MONICA/KORA Myocardial Infarction Registry 4307 patients aged 28-74years with incident AMI with and without history of PAD (information derived from medical chart) were included...
January 5, 2018: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/29307504/the-recurrent-intertriginous-rash
#13
Kang Nien How, Anisha Bhullar
No abstract text is available yet for this article.
January 5, 2018: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/29307505/practical-considerations-in-medical-cannabis-administration-and-dosing
#14
REVIEW
Caroline A MacCallum, Ethan B Russo
Cannabis has been employed medicinally throughout history, but its recent legal prohibition, biochemical complexity and variability, quality control issues, previous dearth of appropriately powered randomised controlled trials, and lack of pertinent education have conspired to leave clinicians in the dark as to how to advise patients pursuing such treatment. With the advent of pharmaceutical cannabis-based medicines (Sativex/nabiximols and Epidiolex), and liberalisation of access in certain nations, this ignorance of cannabis pharmacology and therapeutics has become untenable...
January 4, 2018: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/29307503/prognostic-accuracy-of-qsofa-according-to-the-site-of-infection-in-older-patient-attended-in-emergency-department
#15
LETTER
Angel Estella, Julio Gamazo-Del Rio, Jesús Álvarez-Manzanares, Agustín Julián-Jiménez, Juan González Del Castillo
No abstract text is available yet for this article.
January 4, 2018: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/29306680/exfoliative-esophagitis
#16
Yusaku Kajihara
No abstract text is available yet for this article.
January 3, 2018: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/29306679/two-classical-neurological-syndromes-following-a-stab-wound
#17
Matthew R McCann, Mauricio F Villamar
No abstract text is available yet for this article.
January 3, 2018: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/29306678/exercise-transcutaneous-oximetry-significantly-modifies-the-diagnostic-hypotheses-and-impacts-scheduled-investigations-or-treatments-of-patients-with-exertional-limb-pain
#18
Samir Henni, Guillaume Mahe, Christophe Lamotte, Remi Laurent, Alessandra Bura Riviere, Marion Aubourg, Gabrielle Sarlon, Damien Laneelle, Anne Long, Isabelle Signolet, Jean Picquet, Mathieu Feuilloy, Pierre Abraham
INTRODUCTION: In lower extremity peripheral artery disease (PAD), transcutaneous oximetry at exercise (Ex-TcpO2) has been largely validated in research practice, but evidence of routine practice in various vascular laboratories is missing. We hypothesized that Ex-TcPO2 would change the diagnosis hypotheses, investigations and treatments for patients referred for exertional limb pain. MATERIAL & METHODS: A multicenter prospective trial was conducted in nine different referral centers...
January 3, 2018: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/29305071/effectiveness-of-guideline-consistent-heart-failure-drug-prescriptions-at-hospital-discharge-on-1-year-mortality-results-from-the-epical2-cohort-study
#19
Amandine Busson, Nathalie Thilly, Hervé Laborde-Castérot, François Alla, Ziyad Messikh, Isabelle Clerc-Urmes, Alexandre Mebazaa, Marc Soudant, Nelly Agrinier
BACKGROUND: We aimed to assess the effectiveness of recommended drug prescriptions at hospital discharge on 1-year mortality in patients with heart failure (HF) and reduced ejection fraction (HFREF). MATERIALS AND METHODS: We used data from the EPICAL2 cohort study. HF patients ≥18years old with left ventricular ejection fraction (LVEF) <40% and alive at discharge were included and followed up for mortality. Socio-demographic, clinical and therapeutic data were collected at admission...
January 2, 2018: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/29289421/chronic-obstructive-pulmonary-disease-and-community-acquired-pneumonia-much-more-to-clarify
#20
LETTER
María Del Carmen Santos, Fernando Tornero, María José Núñez Orantos, Esther Rodríguez Adrada, Juan González Del Castillo
No abstract text is available yet for this article.
December 27, 2017: European Journal of Internal Medicine
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