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European Journal of Internal Medicine

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https://www.readbyqxmd.com/read/28633804/protective-effect-of-n-acetylcysteine-on-progression-to-end-stage-renal-disease-necessity-for-prospective-clinical-trial
#1
Chen-Yi Liao, Chi-Hsiang Chung, Chai-Chao Wu, Fu-Huang Lin, Chang-Huei Tsao, Chih-Chiang Wang, Wu-Chien Chien
BACKGROUND: We aimed to evaluate the potential benefits of N-acetylcysteine (NAC) on the risk of chronic kidney disease (CKD) progression to dialysis-requiring end-stage renal disease (ESRDd). METHODS: In a population-based cohort study of 145,062 individuals, 123,608 CKD patients who were followed up for 10years were included, and CKD patients treated with NAC (ICD-9-CM) were compared with those who were not treated. Using propensity score matching, we analyzed the predictors of CKD progression to ESRDd by Cox proportional hazards regression with adjustments for sex, age, and comorbidities, and evaluated the effect of NAC using cumulative defined daily dose (cDDD)...
June 17, 2017: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/28629693/helping-ethics-committees-separate-the-wheat-from-the-chaff
#2
LETTER
Vittorio Bertele', Chiara Gerardi, Silvio Garattini
No abstract text is available yet for this article.
June 16, 2017: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/28629692/is-homeopathy-a-medicine
#3
LETTER
Salvatore Chirumbolo
No abstract text is available yet for this article.
June 16, 2017: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/28625611/comparing-sf-36%C3%A2-scores-versus-biomarkers-to-predict-mortality-in-primary-cardiac-prevention-patients
#4
EDITORIAL
Rony Lahoud, Vasutakarn Chongthammakun, Yuping Wu, Nael Hawwa, Danielle M Brennan, Leslie Cho
BACKGROUND: Risk stratification plays an important role in evaluating patients with no known cardiovascular disease (CVD). Few studies have investigated health-related quality of life questionnaires such as the Medical Outcomes Study Short Form-36 (SF-36®) as predictive tools for mortality, particularly in direct comparison with biomarkers. Our objective is to measure the relative effectiveness of SF-36® scores in predicting mortality when compared to traditional and novel biomarkers in a primary prevention population...
June 15, 2017: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/28615117/impact-of-copd-on-outcomes-in-hospitalized-patients-with-community-acquired-pneumonia-analysis-of-the-spanish-national-hospital-discharge-database-2004-2013
#5
Javier de Miguel-Díez, Ana López-de-Andrés, Valentín Hernández-Barrera, Isabel Jiménez-Trujillo, Manuel Méndez-Bailón, José M de Miguel-Yanes, Rodrigo Jiménez-García
AIM: To examine trends in incidence and outcomes of community-acquired pneumonia (CAP) hospitalizations among patients with or without COPD in Spain (2004-2013). METHODS: We used national hospital discharge data to select all hospital admissions for CAP. Incidence was calculated overall and according to the presence or absence of COPD. RESULTS: We identified 901,136 hospital admissions for CAP (32.25% with COPD). Incidence of hospitalizations of CAP increased significantly over time among patients with and without COPD, but it was higher among people with COPD for all years analyzed...
June 11, 2017: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/28610843/eye-problem-in-zika-virus-infection
#6
LETTER
Viroj Wiwanitkit
No abstract text is available yet for this article.
June 10, 2017: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/28606615/oral-glucose-stimulated-growth-hormone-gh-test-in-adult-gh-deficiency-patients-and-controls-potential-utility-of-a-novel-test
#7
Lara Pena-Bello, Teresa Seoane-Pillado, Susana Sangiao-Alvarellos, Elena Outeiriño-Blanco, Barbara Varela-Rodriguez, Paula Juiz-Valiña, María Cordido, Fernando Cordido
CONTEXT: The diagnosis of adult GH deficiency requires confirmation with a GH stimulation test. Oral glucose (OG) administration affects GH secretion, initially decreasing and subsequently stimulating GH secretion. OBJECTIVE: The aim of this study was to investigate the diagnostic efficacy and safety of a long OG test (LOGT) as a stimulus of GH secretion for the diagnosis of adult GH deficiency (AGHD). DESIGN: Prospective experimental cross-sectional study...
June 9, 2017: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/28602245/lifestyle-changes-as-internal-medicine
#8
LETTER
Daniela Lucini, Chiara Vigo, Mara Malacarne, Wolfgang Gatzemeier, Massimo Pagani
No abstract text is available yet for this article.
June 8, 2017: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/28602244/nitrates-and-osteoporosis-which-relationship
#9
LETTER
Marco Zuin, Gianluca Rigatelli, Fiorenzo Scaranello, Loris Roncon
No abstract text is available yet for this article.
June 8, 2017: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/28601370/impact-of-periodontal-treatment-on-hospitalization-for-adverse-respiratory-events-in-asthmatic-adults-a-propensity-matched-cohort-study
#10
Te-Chun Shen, Pei-Ying Chang, Cheng-Li Lin, Chang-Ching Wei, Chih-Yen Tu, Te-Chun Hsia, Chuen-Ming Shih, Wu-Huei Hsu, Fung-Chang Sung, Chia-Hung Kao
BACKGROUND: Periodontal disease is prevalent in asthmatics, but it is unclear whether periodontal treatment plays a role in adverse respiratory events in these patients. We evaluated risk of hospitalization for adverse respiratory events (acute exacerbation, pneumonia, and acute respiratory failure) and mortality in asthmatic adults with and without periodontal treatment. METHODS: We used National Health Insurance (NHI) claims data of Taiwan to identify 4771 asthmatic adults with periodontal disease who underwent periodontal treatment during 2000-2006...
June 7, 2017: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/28595762/the-use-of-nutritional-risk-screening-2002-to-predict-prognosis-in-hospitalized-patients-with-chronic-obstructive-pulmonary-disease-with-respiratory-failure
#11
LETTER
Ruiqi Chen, Lu Xing, Chao You
No abstract text is available yet for this article.
June 5, 2017: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/28595761/occurrence-of-malignant-neoplasia-in-patients-with-primary-hyperparathyroidism
#12
Serena Palmieri, Letizia Roggero, Elisa Cairoli, Valentina Morelli, Alfredo Scillitani, Iacopo Chiodini, Cristina Eller-Vainicher
No abstract text is available yet for this article.
June 5, 2017: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/28583409/portopulmonary-hypertension-and-hepatorenal-syndrome-two-faces-of-the-same-coin
#13
REVIEW
Enrico Maria Zardi, Domenico Maria Zardi, Chiara Giorgi, Diana Chin, Aldo Dobrina
Portopulmonary hypertension and hepatorenal syndrome are both severe local hypertensive complications of liver cirrhosis and portal hypertension. Both are characterized by vasoconstrictive manifestations regarding pulmonary and renal vascular network, respectively. This review addresses the mechanisms underlying the development of vasoconstriction that leads to local vascular hypertension in the lung and in the kidney with the result of organ dysfunction. Potential therapeutic options are available for the management of these two syndromes as a bridge for liver transplantation; clinical efficacy depends in part on the time and rapidity of intervention and in part on how serious the chain of events is that has triggered the entire vasoconstrictive process...
June 2, 2017: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/28583408/discrimination-ability-of-comorbidity-frailty-and-subjective-health-to-predict-mortality-in-community-dwelling-older-people-population-based-prospective-cohort-study
#14
Sasmita Kusumastuti, Thomas Alexander Gerds, Rikke Lund, Erik Lykke Mortensen, Rudi G J Westendorp
OBJECTIVE: To investigate the added value of comorbidity, frailty, and subjective health to mortality predictions in community-dwelling older people and whether it changes with increasing age. PARTICIPANTS: 36,751 community-dwelling subjects aged 50-100 from the longitudinal Survey of Health, Ageing, and Retirement in Europe. METHODS: Mortality risk associated with Comorbidity Index, Frailty Index, Frailty Phenotype, and subjective health was analysed using Cox regression...
June 2, 2017: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/28579258/factors-associated-with-mild-cognitive-impairment-in-a-population-based-cohort
#15
LETTER
Silvio Buscemi, Valeria Di Pasquale, Carola Buscemi, Tommaso Piccoli, Carla Giordano
No abstract text is available yet for this article.
June 1, 2017: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/28579310/a-comparative-analysis-of-novel-cardiovascular-biomarkers-in-patients-with-chronic-heart-failure
#16
Michael Lichtenauer, Peter Jirak, Bernhard Wernly, Vera Paar, Ilonka Rohm, Christian Jung, Christiana Schernthaner, Johannes Kraus, Lukas J Motloch, Atilla Yilmaz, Uta C Hoppe, P Christian Schulze, Daniel Kretzschmar, Rudin Pistulli
BACKGROUND: Heart failure (HF) with reduced ejection fraction remains a major therapeutic challenge. The aim of this study was to investigate the role of novel cardiovascular biomarkers, i.e. soluble suppression of tumorigenicity (sST2), growth-differentiation factor-15 (GDF-15), soluble urokinase plasminogen activator receptor (suPAR) and heart-type fatty acid binding protein (H-FABP) in patients with ischaemic (ICM) or dilative cardiomyopathy (DCM). MATERIALS AND METHODS: A total of 200 patients were enrolled in this study: 65 were diagnosed with DCM and 59 patients suffering from ICM were included...
May 31, 2017: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/28579309/genetic-variation-in-the-first-pass-metabolism-of-ethinylestradiol-sex-hormone-binding-globulin-levels-and-venous-thrombosis-risk
#17
Bernardine H Stegeman, Hans L Vos, Frans M Helmerhorst, Frits R Rosendaal, Pieter H Reitsma, Astrid van Hylckama Vlieg
BACKGROUND: Use of ethinylestradiol, one of the active ingredients in combined oral contraceptives, affects the incidence of venous thrombosis. To explain why some women develop thrombosis when using oral contraceptives and others do not, we hypothesized a role for the first-pass metabolism of ethinylestradiol in the liver. We set out to determine the association between genetic variation in the first-pass metabolism of ethinylestradiol, venous thrombosis risk and the effect on Sex-hormone-binding-globulin (SHBG) levels...
May 31, 2017: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/28576398/characterization-of-circadian-copd-symptoms-by-phenotype-methodology-of-the-storico-observational-study
#18
G W Canonica, F Blasi, N Scichilone, L Simoni, A Zullo, C Giovannetti, C Briguglio, S Barsanti, R Antonelli Incalzi
Chronic obstructive pulmonary disease (COPD) is one of the leading causes of morbidity and mortality worldwide. The symptoms of COPD are troublesome, variable, can occur during all parts of the 24-h day and have a substantial impact on patients' health status, quality of life and healthcare resource utilization. Reducing symptoms, improving health status and increasing physical activity are major goals in the management of stable COPD. In order to provide effective, patient-oriented care, patients should be evaluated on the basis of lung function, frequency of symptoms and patient-perceived impact of symptoms on their lives and treatment decisions made on a case-by-case basis...
May 30, 2017: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/28576397/the-contribution-of-clinical-and-pathological-predisposing-factors-to-severe-gastro-duodenal-lesions-in-patients-with-long-term-low-dose-aspirin-and-proton-pump-inhibitor-therapy
#19
Anca Negovan, Mihaela Iancu, Valeriu Moldovan, Kinga Sàrkàny, Simona Bataga, Simona Mocan, Ioan Țilea, Claudia Banescu
BACKGROUND: Preventive strategies developed to avoid the complications of antiplatelet therapies recommend the evaluation of risk factors for gastrointestinal events and indicated gastroprotective strategies. AIM: We aimed to assess the impact of predisposing factors - histological findings, concomitant drug consumption, comorbidities, symptoms, social habits, Helicobacter pylori infection - on severe gastro-duodenal lesions in patients with low-dose aspirin and concomitant protective therapy with proton pump inhibitors (PPI)...
May 30, 2017: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/28571895/timing-of-syncope-during-blood-sampling-the-maastricht-study
#20
LETTER
Remy J H Martens, Stefan L C Geijselaers, Coen D A Stehouwer, Ronald M A Henry
No abstract text is available yet for this article.
May 29, 2017: European Journal of Internal Medicine
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