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Journal of Molecular Neuroscience: MN

Efthimios Dardiotis, Athina-Maria Aloizou, Vasileios Siokas, George P Patrinos, Georgia Deretzi, Panayiotis Mitsias, Michael Aschner, Aristidis Tsatsakis
Amyotrophic lateral sclerosis (ALS) is a serious neurodegenerative disease that affects motor neurons and leads to death within 2 to 3 years after the first symptoms manifest. MicroRNAs (miRNAs) are small non-coding RNA molecules that regulate gene expression in fundamental cellular processes and, post-transcriptionally, the translation levels of target mRNA transcripts. We searched PubMed for studies that examined miRNAs in ALS patients and attempted to group the results in order to find the strongest miRNA candidate for servings as an ALS biomarker...
November 10, 2018: Journal of Molecular Neuroscience: MN
Dan Ye, Yao Yang, Xi Lu, Yue Xu, Yuxun Shi, Hailiu Chen, Jingjing Huang
Pituitary adenylate cyclase-activating polypeptide (PACAP) has been demonstrated to play a crucial part in protecting retinal ganglion cells (RGCs) from apoptosis in various retinal injury animal models. PACAP has two basic groups of receptors: PACAP receptor type 1 (PAC1R) and vasoactive intestinal polypeptide/PACAP receptors (VPAC1R and VPAC2R). However, few studies illustrated the spatial and temporal expression changes of endogenous PACAP and its receptors in a rodent optic nerve crush (ONC) model. In this study, a significant upregulation of PACAP and PAC1R in the retina after ONC was observed in both protein and RNA levels...
November 10, 2018: Journal of Molecular Neuroscience: MN
Fangfang Song, Tingting Liu, Songyan Meng, Fengqing Li, Yina Zhang, Lihong Jiang
To examine the effect of subcutaneous injection of insulin-like growth factor-1 (IGF-1) on the expression of the amyloid protein (Aβ1-40 ), α-secretase (ADAM10), β-secretase (BACE1), and γ-secretase (PS1) in APP/PS1 double transgenic mice. APP/PS1 double transgenic mice and wild-type mice were divided into wild-type group, wild-type therapy group, transgenome group, and transgenic therapy group. Subcutaneous injection of IGF-1 (50 μg/kg day) was administered once daily to the wild-type therapy group and transgenic therapy group for 8 weeks, respectively...
November 9, 2018: Journal of Molecular Neuroscience: MN
Min-Koo Park, Ji-Won Lee, Jeong-Chan Lee, Sung-Joo Hwang, Hyun Woong Roh, Chang Hyung Hong, Sang Joon Son
Epigenetic dysregulation has been known to be involved in neurodegenerative diseases, including amnestic mild cognitive impairment (MCI). The aim of this study was to investigate the genome-wide DNA methylation analysis, in order to identify epigenetic dysregulation in blood from patients with MCI. Here, we investigated whether epigenetic dysregulation in MCI and whether such an aberration could be detected in blood circulation. Genome-wide bisulfite sequencing targeted 84 million bases covering 3.7 million CpG sites was comparatively analyzed in MCI and control groups...
November 5, 2018: Journal of Molecular Neuroscience: MN
Qian Zhang, Mengting Zhang, Jiaqi Li, Hai Xiao, Dong Wu, Qiannan Guo, Yuwei Zhang, Hongdan Wang, Shengbin Li, Shixiu Liao
The expression of reference genes should be constitutively stable under the experimental conditions, so determining stable reference genes is critical for obtaining reliable results in gene expression studies. Morphine addiction persistently influences neurotransmitters and signal transduction systems, which may negatively alter behavioral responses at the cellular levels and interfere the expression of reference genes. In order to research morphine dependence, animal models are commonly used in physiology, pathology, and therapeutics field since human trials have many limitations...
November 1, 2018: Journal of Molecular Neuroscience: MN
Pritha Gupta, Susmita Sil, Rupsa Ghosh, Arijit Ghosh, Tusharkanti Ghosh
An important marker in Alzheimer disease (AD) is the abnormal production and accumulation of β-amyloid peptide (Aß) in brain. It produces oxidative damage in neurons and inflammation due to its neurotoxic properties. The present study was designed to investigate neuroinflammation (hippocampal levels of ROS, nitrite, TNF-α, and IL-1β), neurodegeneration (plaques and chromatolysis in hippocampus), and memory impairments (working memory and reference memory) and the effect of this neuroinflammation on some peripheral immunological parameters such as phagocytic activity of blood WBC and splenic polymorphonuclear (PMN) cells, leucocyte adhesion inhibition index (LAI), and cytotoxicity of splenic mononuclear cells (MNC) after the intracebroventricular injection of aggregated Aβ(1-42) in a 4week study...
October 31, 2018: Journal of Molecular Neuroscience: MN
Maria Lazarova, Andrey Popatanasov, Radoslav Klissurov, Svetlana Stoeva, Tamara Pajpanova, Reni Kalfin, Lyubka Tancheva
Close functional and anatomical interactions between the neurotensin (NT) and dopamine (DA) systems suggest that NT could be associated with Parkinson's Disease (PD). However, clinical use of NT is limited due to its rapid degradation. This has led to the synthesis of a number of new NT fragment 8-13 [NT(8-13)] analogues, such as NT2 and NT4, to avoid the fast biodegradation of NT. The aim of this study was to investigate the neuroprotective effects of NT2 and NT4 on an experimental model of Parkinson's disease in rats induced with 6-hydroxydopamine (6-OHDA) treatment, producing striatal lesions...
October 30, 2018: Journal of Molecular Neuroscience: MN
Christina Van, Michael C Condro, Kenny Lov, Ruoyan Zhu, Patrick T Ricaflanca, Henly H Ko, Anna L Diep, Anh Q Hoang, Joseph Pisegna, Hermann Rohrer, James A Waschek
The original version of this article unfortunately contained mistakes. The captured article title and corresponding author were incorrect.
October 26, 2018: Journal of Molecular Neuroscience: MN
Geir Bjørklund, Nagwa A Meguid, Afaf El-Ansary, Mona A El-Bana, Maryam Dadar, Jan Aaseth, Maha Hemimi, Joško Osredkar, Salvatore Chirumbolo
Autism spectrum disorder (ASD) is a neurodevelopmental disorder afflicting about one in every 68 children. It is behaviorally diagnosed based on a triad of symptoms, including impairment in communication, impairment in sociability and abnormal and stereotypic behavior. The subjectivity of behavioral diagnosis urges the need for clinical biomarker tests to improve and complement ASD diagnosis and treatment. Over the past two decades, researchers garnered a broad range of biomarkers associated with ASD and often correlating with the severity of ASD, which includes metabolic and genetic biomarkers or neuroimaging abnormalities...
October 24, 2018: Journal of Molecular Neuroscience: MN
Panagiotis Zis, Patrick C McHugh, Maurizio Manca, Ptolemaios Georgios Sarrigiannis, Dasappaiah Ganesh Rao, Marios Hadjivassiliou
Chronic idiopathic axonal polyneuropathy (CIAP) is a disorder with insidious onset and slow progression, where no etiology is identified despite appropriate investigations. We aimed to investigate the role of oxidative stress as a risk factor for the pathogenesis of CIAP. Sera of patients with CIAP were tested for protein carbonyl (PC) and 8-hydroxydeoxyguanosine (8H). As a control group, we recruited patients with gluten neuropathy. Twenty-one patients with CIAP and 21 controls were recruited. The two groups did not differ significantly regarding demographics or clinical characteristics (i...
October 22, 2018: Journal of Molecular Neuroscience: MN
Haicheng Yuan, Chuanwu Jiang, Jingde Zhao, Yunsheng Zhao, Yongbin Zhang, Yanqi Xu, Xiaoning Gao, Lingfei Guo, Yongji Liu, Kai Liu, Bo Xu, Gang Sun
Alzheimer's disease (AD) is the most common neurodegenerative disorder and is characterized by the deposition of β-Amyloid (Aβ) plaques which contribute to its pathology. The present study was aimed at exploring the protective effects of euxanthone against Aβ-induced neurotoxicity both in vivo and in vitro. We found that euxanthone significantly attenuated Aβ1-42 -induced memory and spatial learning dysfunction and also significantly reversed Aβ1-42 -induced neuronal apoptosis and autophagy in the hippocampal region...
October 22, 2018: Journal of Molecular Neuroscience: MN
Dan Gao, Rui Zhang, Guofa Ji, Chunqi Li, Dangshe Guo, Tianbo Jin, Mingwei Chen
This study aimed to further understand the role of relative telomere length (RTL) in susceptibility to stroke and investigate the association regulator of telomere elongation helicase 1 (RETL1) gene polymorphisms and RTL. RTL was measured using the real-time quantitative polymerase chain reaction (qPCR) from 300 stroke patients and 299 healthy controls. Genotyping was performed using the Sequenom MassARRAY platform. The results indicated that stroke patients had significantly shorter median RTL than controls (P < 0...
October 22, 2018: Journal of Molecular Neuroscience: MN
Nagwa A Meguid, Hatem Samir, Geir Bjørklund, Mona Anwar, Adel Hashish, Farouk Koura, Salvatore Chirumbolo, Saher Hashem, Mona A El-Bana, Hebatalla S Hashem
Mesial temporal lobe epilepsy (MTLE) associated with hippocampal sclerosis (HS) is the most common form of partial epilepsy. The aim of the present study is to highlight possible and suitable biomarkers that can help in the diagnosis and prognosis of this intractable form of epilepsy. The study was carried out on 30 epileptic patients of both sexes with complex partial seizures, having an age ranging from 4 to 30 years and were selected from the outpatient epilepsy clinic at the Kasr El-Aini Hospital in Cairo, Egypt...
October 20, 2018: Journal of Molecular Neuroscience: MN
Hadhemi Kaddour, Yosra Hamdi, Fatma Amri, Seyma Bahdoudi, Ibtissem Bouannee, Jérôme Leprince, Sami Zekri, Hubert Vaudry, Marie-Christine Tonon, David Vaudry, Mohamed Amri, Sana Mezghani, Olfa Masmoudi-Kouki
Oxidative stress, associated with various neurodegenerative diseases, promotes ROS generation, impairs cellular antioxidant defenses, and finally, triggers both neurons and astroglial cell death by apoptosis. Astrocytes specifically synthesize and release endozepines, a family of regulatory peptides, including the octadecaneuropeptide (ODN). We have previously reported that ODN acts as a potent neuroprotective agent that prevents 6-OHDA-induced apoptotic neuronal death. The purpose of the present study was to investigate the potential glioprotective effect of ODN on 6-OHDA-induced oxidative stress and cell death in cultured rat astrocytes...
October 20, 2018: Journal of Molecular Neuroscience: MN
Dekun Yin, Yonglin Chen, Rongxiang Lu, Bingbing Fan, Shunxing Zhu, Xingguo Xu, Zhongling Xu
Neuropathic pain is a severe debilitating state caused by injury or dysfunction of somatosensory nervous system, and the clinical treatment is still challenging. Translocation associated membrane protein 1 (TRAM1), an adapter protein, participates in a variety of transduction pathways and mediates the biological functions such as cell proliferation, activation, and differentiation. However, whether TRAM1 is involved in the pathogenesis of neuropathic pain is still unclear. In our study, we reported the role of TRAM1 in the maintenance of neuropathic pain induced by chronic constriction injury (CCI) on rats...
October 18, 2018: Journal of Molecular Neuroscience: MN
Asghar Farajzadeh, S Zahra Bathaie, Jalil Arabkheradmand, Seyed Mohammad Ghodsi, Soghrat Faghihzadeh
Trigeminal neuralgia (TN) with chronic and severe neuropathic pain leads to remarkable interference in daily living activities of patients. Unknown molecular mechanisms involved in TN pathophysiology are a challenge for complete treatment of the disease. The present study was conducted to investigate changes in the plasma proteome beside biochemical parameters, including calcitonin gene-related peptide (CGRP), nitric oxide (NO), amino acids, and vitamin D (Vit D) in different pain states in TN patients. Plasma samples were obtained from the control group (#13) and patients with purely paroxysmal type of classical TN (#13) before and after microvascular decompression (MVD)...
October 17, 2018: Journal of Molecular Neuroscience: MN
Jacqueline Ojala, Katharine Tooke, Harrison Hsiang, Beatrice M Girard, Victor May, Margaret A Vizzard
Neural injury, inflammation, or diseases commonly and adversely affect micturition reflex function that is organized by neural circuits in the CNS and PNS. One neuropeptide receptor system, pituitary adenylate cyclase-activating polypeptide (PACAP; Adcyap1), and its cognate receptor, PAC1 (Adcyap1r1), have tissue-specific distributions in the lower urinary tract. PACAP and associated receptors are expressed in the LUT and exhibit changes in expression, distribution, and function in preclinical animal models of bladder pain syndrome (BPS)/interstitial cystitis (IC), a chronic, visceral pain syndrome characterized by pain, and LUT dysfunction...
September 27, 2018: Journal of Molecular Neuroscience: MN
Madiha Ahmed, Ihsan Ul Haq, Muhammad Faisal, Durdana Waseem, Malik Mumtaz Taqi
The original version of this article is missing the Acknowledgments section.
September 14, 2018: Journal of Molecular Neuroscience: MN
Sha Wang, Bai-Xue Wu, Chao-Yang Liu, Guang-Cheng Qin, Wen-Hui Yan, Ji-Ying Zhou, Li-Xue Chen
Acid-sensing ion channel 3 (ASIC3) is abundant in the trigeminal nervous system and is most sensitive to a slight pH decrease. Recent studies have indicated that ASIC3 in the peripheral trigeminal ganglia is likely involved in the pathogenesis of migraine pain. However, it is unclear whether this receptor plays a role in recurrent migraine, namely, migraine chronicity. Here, we aimed to investigate the role of ASIC3 in an animal model of recurrent migraine (RM). In this study, we established a rat model of RM through repeated administration of inflammatory soup (IS) onto the dura...
September 12, 2018: Journal of Molecular Neuroscience: MN
Rui Zhang, Cui Liu, Yaqing Ji, Lei Teng, Yunliang Guo
This study investigated the effects of neuregulin-1β (NRG1β) after middle cerebral artery occlusion/reperfusion (MCAO/R) in rats to evaluate whether they occur via the cyclin-dependent kinase (Cdk)5 signaling pathway. One hundred adult male Wistar rats were randomly divided into sham, MCAO/R, treatment (NRG1β), inhibitor (roscovitine; Ros), and inhibitor + treatment (Ros + NRG1β) groups. The MCAO/R model was established using the intraluminal thread method. The neurobehavioral function was evaluated by the modified neurological severity score (mNSS)...
September 11, 2018: Journal of Molecular Neuroscience: MN
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