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Journal of Molecular Neuroscience: MN

Vasileios Siokas, Dimitrios Kardaras, Athina-Maria Aloizou, Ioannis Asproudis, Konstadinos G Boboridis, Eleni Papageorgiou, Demetrios A Spandidos, Aristidis Tsatsakis, Evangelia E Tsironi, Efthimios Dardiotis
Blepharospasm (BSP) is a sub-phenotype of focal dystonia. A few genetic risk factors are considered to be implicated in the risk of developing BSP. There is recent evidence, based on results from GWAS and meta-analyses, to suggest that arylsulfatase G (ARSG), and more specifically rs11655081, is implicated in focal dystonia. The aim of the present study was to evaluate the effect of rs11655081 ARSG on BSP. A Greek cohort, which consisted of 206 BSP patients and an equal number of healthy controls, was genotyped for rs11655081...
January 18, 2019: Journal of Molecular Neuroscience: MN
Juhi Singh, Kedarlal Sharma, Emma E Frost, Prakash P Pillai
Oligodendrocyte progenitor cells (OPCs) originate from the sub-ventricular zone of the developing brain. They migrate and proliferate to occupy the white matter tracts of the central nervous system and transform into myelinating oligodendrocytes. Along their route of migration, OPCs are guided and controlled by several growth factors and chemokines. PDGF-A (platelet-derived growth factor), a growth factor, serves as a monogenic and mitogenic cue during the process and activates intracellular signaling pathways inside the cell...
January 16, 2019: Journal of Molecular Neuroscience: MN
Bin Zhou, Hong-Yun Liu, Bao-Lian Zhu
We attempted to explore the possible effects of SOCS3 (suppressor of cytokine signaling 3)-modified bone marrow mesenchymal stem cells (BMSCs) on the hypoxic injury of rat adrenal gland pheochromocytoma (PC-12) cells. PC12 cells were cultured with EGFP (enhanced green fluorescent protein)-BMSCs and SOCS3-BMSCs respectively under hypoxia in vitro and classified into control, hypoxia, EGFP-BMSCs, and SOCS3-BMSC groups. CCK-8, Hoechst 33258 staining, and Annexin V-FITC/PI staining were assessed to measure the viability and apoptosis of hypoxia-induced PC12 cells...
January 15, 2019: Journal of Molecular Neuroscience: MN
Shuxia Qian, Yanping Wang, Xiaoling Zhang
Although histamine inhibitors have been used in the motility-associated vertigo, the link between histamine and sleep deprivation (SD)-induced vertigo has not been clearly demonstrated. The histamine plasma levels were assayed in the SD volunteers before SD and 24 h after SD. Pinnacle's automated sleep deprivation system was used to establish the female C57BL/6 mice SD model. Histidine decarboxylase inhibitor 4-bromo-3-hydroxybenzoic acid (BHOA), and antihistamine diphenhydramine (DPHM) were injected intraperitoneally to test their effects on SD-induced vertigo...
January 15, 2019: Journal of Molecular Neuroscience: MN
Qiong Wu, Jingfang Song, Danxin Meng, Quanzhong Chang
High level of corticosterone (CORT) is toxic to neurons and plays an important role in depression-like behavior and chronic stress. Our previous study showed that TPPU, a soluble epoxide hydrolase (sEH) inhibitor (sEHI), induces an antidepressant effect in animal models. However, the underlying mechanism is not clear. In this study, we investigated the protective effect of TPPU on PC12 cells against CORT-induced cytotoxicity and its underlying mechanism. We found that TPPU and the sEH substrate epoxyeicosatrienoic acids (EETs) protected PC12 cells from the CORT-induced injury by increasing cell viability and inhibiting apoptosis...
January 14, 2019: Journal of Molecular Neuroscience: MN
Fatima Zahra Ouardi, Hammou Anarghou, Hafsa Malqui, Nabila Ouasmi, Mohammed Chigr, Mohamed Najimi, Fatiha Chigr
Environmental factors such as pesticides are considered key determinants of brain damage and brain dysfunction. In the present work, we investigated the effect of an organophosphate pesticide, i.e., malathion, administrated peri- and postnatally on the antioxidant system as well as on acetylcholine esterase (AChE) activity in the brains of mice pups during the three postnatal weeks. Furthermore, we analyzed the behavior of the offspring just after weaning to assess the eventual effect of the pesticide on anxiety traits and social interaction...
January 12, 2019: Journal of Molecular Neuroscience: MN
Ari Robinson, Irit Lubitz, Dana Atrakchi-Baranes, Avital Licht-Murava, Pavel Katsel, Derek Leroith, Sigal Liraz-Zaltsman, Vahram Haroutunian, Michal Schnaider Beeri
Disruption of brain insulin signaling may explain the higher Alzheimer's disease (AD) risk among type 2 diabetic (T2D) patients. There is evidence from in vitro and human postmortem studies that combination of insulin with hypoglycemic medications is neuroprotective and associated with less amyloid aggregation. We examined the effect of 8-month intranasal administration of insulin, exenatide (a GLP-1 agonist), combination therapy (insulin + exenatide) or saline, in wild-type (WT) and an AD-like mouse model (Tg2576)...
January 11, 2019: Journal of Molecular Neuroscience: MN
Erdinç Dursun, Merve Alaylıoğlu, Başar Bilgiç, Haşmet Hanağası, Hakan Gürvit, Murat Emre, Duygu Gezen-Ak
Adsorption of CSF Aβ1-42 during pre-analytical processing is suggested as an important confounder in testing. The aim of the present study was to assess the effect of polypropylene transfer plates (PTP) in the INNOTEST Aβ1-42 IVD-ELISA assay on Aβ1-42 levels. CSF samples from 26 individuals with subjective cognitive impairment (SCI) and 25 patients with suspected neurodegenerative disorders were tested using four different lots of kits. Aβ1-42 levels in all samples that were loaded onto the PTP were significantly lower than the levels in the same samples that were analyzed without prior loading onto the PTP...
January 11, 2019: Journal of Molecular Neuroscience: MN
Miriam Kolnikova, Petra Jungova, Martina Skopkova, Tomas Foltan, Daniela Gasperikova, Slavomira Mattosova, Jan Chandoga
Impairment of saposin B causes rare atypical metachromatic leukodystrophy (MLD). It is encoded (together with saposin A, C, and D) by the PSAP gene. Only ten pathogenic variants were described in the PSAP gene in MLD patients to date. We report on two novel variants in the PSAP gene - c.679_681delAAG in the saposin B encoding exon 6 and c.1268delT in the saposin D encoding exon 11 in a patient with MLD. We discuss the fact, that variants resulting in PSAP null allele can be shared in patients with the deficit of other saposins (A-D) or whole prosaposin...
January 11, 2019: Journal of Molecular Neuroscience: MN
Hedyeh Faghir-Ghanesefat, Hedieh Keshavarz-Bahaghighat, Nazanin Rajai, Tahmineh Mokhtari, Erfan Bahramnejad, Soheil Kazemi Roodsari, Ahmad Reza Dehpour
Preconditioning is defined as an induction of adaptive response in organs against lethal stimulation provoked by subsequent mild sublethal stress. Several chemical agents have been demonstrated to cause brain tolerance through preconditioning. The aim of the present study is to test the hypothesis that preconditioning with pentylenetetrazole (PTZ) may have protective effect against seizure induced by i.v. infusion of PTZ. Mice were preconditioned by low-dose administration of PTZ (25 mg/kg) for 5 consecutive days, and the threshold of seizure elicited by i...
January 10, 2019: Journal of Molecular Neuroscience: MN
Shan Wu, Sheng Deng, Zhi Song, Hongbo Xu, Zhijian Yang, Xin Liu, Li Qi, Hao Deng, Lamei Yuan
In this report, we described a large Han-Chinese family which presents with various phenotypes from unaffected to manifested nystagmus in females. Infantile nystagmus (IN) is characterized by bilateral, involuntary, and periodic eyeball oscillation, occurring at birth or within the first 6 months. The most common inheritance pattern of IN is an X-linked form with incomplete penetrance among females, and the FERM domain containing 7 gene (FRMD7) is a main disease-causing gene. A combination of exome sequencing and Sanger sequencing, as well as detailed clinical examinations were performed on the Chinese IN family...
January 8, 2019: Journal of Molecular Neuroscience: MN
Niloufar Yousefi, Fattah Sotoodehnejadnematalahi, Nooshin Heshmati-Fakhr, Mohammad Sayyah, Masoud Hoseini, Soheil Ghassemi, Shayan Aliakbari, Hamid Gholami Pourbadie
Soluble amyloid beta (Aβ) oligomers are the most common forms of Aβ in the early stage of Alzheimer's disease (AD). They are highly toxic to the neurons but their capability to activate microglia remains controversial. Microglia develop two distinct phenotypes, classic (M1) and alternative (M2). Tuning of microglia to the alternative (anti-inflammatory) state is of major interest in treatment of neuroinflammatory disease. This study aimed to assess tuning the microglia to produce interferon beta (IFN-β) as an anti-inflammatory cytokine through TLR4 pathway in a rat model of AD...
January 4, 2019: Journal of Molecular Neuroscience: MN
Jalal Gharesouran, Mohammad Taheri, Arezou Sayad, Soudeh Ghafouri-Fard, Mehrdokht Mazdeh, Mir Davood Omrani
Long non-coding RNAs (lncRNAs) play critical roles in regulation of immunological pathways. Consequently, their expression profile represents new biomarkers for susceptibility and progression of immunological disorders. However, their role in chronic inflammatory diseases such as multiple sclerosis (MS) remained unknown. Here, we assessed the expression of lncRNAs MALAT1 and HOTAIRM1 as well as their target genes in peripheral blood of MS patients to show their possible roles in disease initiation and progression...
January 4, 2019: Journal of Molecular Neuroscience: MN
Hongmei Zhang, Qiying Zhang, Zuning Liao
This study aimed to explore the molecular mechanism of stroke and provide a new target in the clinical management. The miRNA dataset GSE97532 (3 blood samples from middle cerebral artery occlusion (MCAO) and 3 from sham operation) and mRNA dataset GSE97533 (3 blood samples from MCAO and 3 from sham operation) were obtained from GEO database. Differentially expressed mRNA (DEGs) and miRNAs (DEMIRs) were screened out between MCAO and sham operation groups. Then, DEMIR-DEG interactions were explored and visualized using Cytoscape software...
January 4, 2019: Journal of Molecular Neuroscience: MN
Yan Zhuang, Hui Xu, Seidu A Richard, Jie Cao, Haiying Li, Haitao Shen, Zhengquan Yu, Jian Zhang, Zhong Wang, Xiang Li, Gang Chen
Exchange proteins directly activated by cAMP (EPACs) are critical cAMP-dependent signaling pathway intermediaries that have been implicated in the pathogenesis of several human diseases, particularly neurological disorders. However, their pathogenic role in secondary brain injury (SBI) induced by intracranial hemorrhage (ICH) is unknown. The aim of this study was to examine the effects of EPAC2 on ICH-induced SBI and its underlying mechanisms. An in vivo ICH model was established in Sprague-Dawley rats by autologous blood injection...
January 3, 2019: Journal of Molecular Neuroscience: MN
Geir Bjørklund, Mostafa I Waly, Yahya Al-Farsi, Khaled Saad, Maryam Dadar, Md Mostafizur Rahman, Amira Elhoufey, Salvatore Chirumbolo, Jagoda Jóźwik-Pruska, Joanna Kałużna-Czaplińska
Vitamin or mineral supplementation is considered to be the most commonly used medical treatment for autism spectrum disorder (ASD), in addition to other interventions such as neurological and psychological interventions. There is not much evidence of therapeutic efficacy between vitamin and mineral supplementation and improvements in ASD. However, several researchers have noted that patients with ASD have various metabolic and nutritional abnormalities including issues with sulfation, methylation, glutathione redox imbalances, oxidative stress, and mitochondrial dysfunction...
January 3, 2019: Journal of Molecular Neuroscience: MN
Fatin H Mohamad, Ahmad Tarmizi Che Has
GABAA receptors are the major inhibitory neurotransmitter receptor in the human brain. The receptors are assembled from combination of protein subunits in pentameric complex which may consist of α1-6, β1-3, γ1-3, ρ1-3, δ, ε, θ, or π subunits. There are a theoretical > 150,000 possible assemblies and arrangements of GABAA subunits, although only a few combinations have been found in human with the most dominant consists of 2α1, 2β2, and 1γ2 in a counterclockwise arrangement as seen from the synaptic cleft...
January 3, 2019: Journal of Molecular Neuroscience: MN
Rayssa Leal Borges-Medeiros, Laura Durão Ferreira, João Ricardo Mendes de Oliveira
Primary familial brain calcification (PFBC) is a rare neurodegenerative disorder characterized by symmetrical and bilateral brain calcification. It is typically inherited as an autosomal dominant disorder, and de novo variants have also been described. Interestingly, just recent studies have reported the first autosomal recessive PFBC-causative gene. PFBC patients exhibit high clinical heterogeneity including Parkinsonism, dystonia, ataxia, depression, and migraine. Mice studies, an important research tool, have been a breakthrough in increasing the understanding of PFBC's main signs and symptoms, and many findings reported in these mice have been subsequently reported in patients...
January 3, 2019: Journal of Molecular Neuroscience: MN
Thainá Fernandez Gonçalves, Rafael Mina Piergiorge, Jussara Mendonça Dos Santos, Jaqueline Gusmão, Márcia Mattos Gonçalves Pimentel, Cíntia Barros Santos-Rebouças
MicroRNAs are endogenous non-protein-coding RNA molecules that regulate post-transcriptional gene expression. The majority of human miRNAs are brain-expressed and chromosome X is enriched in miRNA genes. We analyzed the genomic regions of 12 brain-expressed pre-miRNAs located on chromosome X coding for 18 mature miRNAs, aiming to investigate the involvement of miRNA sequence variants on X-linked intellectual disability (XLID). Genomic DNA samples from 135 unrelated Brazilian males with intellectual disability, suggestive of X-linked inheritance, were amplified through polymerase chain reaction and sequenced by Sanger sequencing...
January 3, 2019: Journal of Molecular Neuroscience: MN
Enyao Li, Pengju Zhao, Jie Jian, Hong Wu, Shuibo Gao, Hongyin Zhai
To study the clinical effectiveness and mechanism of GM1 acupoint injection therapy on mental retardation for children with cerebral palsy (CP). A total of 90 children with CP were divided into acupoint injection group (group A), subcutaneous injection group (group B), and control group (group C). Another 30 healthy children were set as a healthy control group (group D). The Mental Developmental Index (MDI), Psychomotor Developmental Index (PDI), and hemodynamic parameters in the cerebral arteries were measured before and after treatment...
January 2, 2019: Journal of Molecular Neuroscience: MN
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