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Journal of Molecular Neuroscience: MN

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https://www.readbyqxmd.com/read/29774516/periodic-variation-of-aak1-in-an-a%C3%AE-1-42-induced-mouse-model-of-alzheimer-s-disease
#1
Xue Fu, Meiling Ke, Weihua Yu, Xia Wang, Qian Xiao, Min Gu, Yang Lü
Inhibition of endocytosis in an Alzheimer's disease (AD) model has been shown to be able to prevent amyloid β (Aβ)-induced damage and to exert a beneficial effect in treating AD. Adaptor-associated kinase 1 (AAK1), which binds to the adaptor protein complex 2 (AP-2), regulates the process of clathrin-mediated endocytosis. However, how AAK1 expression varies over the course of AD is unknown. In this study, we investigated AAK1 levels in AD model mice over time. Aβ1-42 was used to establish a mouse AD model, and the Morris water maze test was used to characterize the time course of Aβ1-42 -induced cognition changes...
May 17, 2018: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/29754213/pathogenesis-of-alzheimer-s-disease-examined-using-a-modified-puri-li-model-that-incorporates-calcium-ion-homeostasis
#2
R A Thuraisingham
The Puri-Li kinetic model is modified to include neuronal calcium ion homeostasis to study the effect of calcium ions on the production of amyloid-β peptides (Aβ), microglia, and astroglia during the pathogenesis of Alzheimer's disease (AD). This is carried out by solving the modified Puri-Li model under steady-state conditions. The derived expressions show that the inclusion of calcium ions has altered the steady-state populations of Aβ, microglia, and astroglia. The calcium ions activate the synthesis of Aβ which in turn increases the calcium ions entering the cytoplasm of the neuronal cells, thus creating a positive loop...
May 13, 2018: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/29744740/co-expression-of-%C3%AE-subunits-with-the-voltage-gated-sodium-channel-na-v-1-7-the-importance-of-subunit-association-and-phosphorylation-and-their-effects-on-channel-pharmacology-and-biophysics
#3
Maxim V Sokolov, Petra Henrich-Noack, Carina Raynoschek, Bo Franzén, Olof Larsson, Martin Main, Michael Dabrowski
The voltage-gated sodium ion channel NaV 1.7 is crucial in pain signaling. We examined how auxiliary β2 and β3 subunits and the phosphorylation state of the channel influence its biophysical properties and pharmacology. The human NaV 1.7α subunit was co-expressed with either β2 or β3 subunits in HEK-293 cells. The β2 subunits and the NaV 1.7α, however, were barely associated as evidenced by immunoprecipitation. Therefore, the β2 subunits did not change the biophysical properties of the channel. In contrast, β3 subunit was clearly associated with NaV 1...
May 10, 2018: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/29737465/gaba-a-receptor-density-is-not-altered-by-a-novel-herbal-anxiolytic-treatment
#4
Ravid Doron, Avital Sever, Assaf Handelsman, Roni Toledano, Motty Franko, Yafit Hirshler, Alon Shamir, Or Burstein, Moshe Rehavi
Anxiety disorders are highly prevalent and considered a major public health concern worldwide. Current anxiolytics are of limited efficacy and associated with various side effects. Our novel herbal treatment (NHT), composed of four constituents, was shown to reduce anxiety-like behavior while precluding a common side effect caused by current anxiolytics, i.e., sexual dysfunction. Nevertheless, NHT's mechanism of action is yet to be determined. There is evidence that some medicinal herbs interact with the GABAergic system...
May 8, 2018: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/29736818/transcriptome-profiling-reveals-phlda1-as-a-novel-molecular-marker-for-ischemic-cardiomyopathy
#5
Jinhui Wang, Feifei Wang, Jingbin Zhu, Mei Song, Jinghong An, Weimin Li
Ischemic cardiomyopathy (ICM) represents a worldwide health issue owning to its high sudden death rate. Easy diagnosis and effective treatment of ICM are still lacking. Identification of novel molecular markers will help illustrate the pathophysiology of ICM and facilitate its diagnosis and targeted treatment. Transcription profiling could be an easy and efficient way for identifying new markers. However, the mega data in the available database may contain a large number of false-positive hits. To identify the true marker for ICM, we systematically compared available microarray datasets in the GEO database and identified 26 genes that are shared by all datasets...
May 8, 2018: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/29732484/crispr-cas9-the-powerful-new-genome-editing-tool-for-putative-therapeutics-in-obesity
#6
REVIEW
María José Franco-Tormo, Mireille Salas-Crisostomo, Nuno Barbosa Rocha, Henning Budde, Sérgio Machado, Eric Murillo-Rodríguez
The molecular technology known as clustered regularly interspaced palindromic repeats (CRISPR)/CRISPR-associated protein (Cas) is revolutionizing the field of medical research and deepening our understanding of numerous biological processes. The attraction of CRISPR/Cas9 lies in its ability to efficiently edit DNA or modulate gene expression in living eukaryotic cells and organisms, a technology that was once considered either too expensive or scientifically risky. CRISPR/Cas9 has been successfully applied in agriculture to develop the next generation of disease-resistant plants...
May 7, 2018: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/29728964/the-mechanism-of-hyperalgesia-and-anxiety-induced-by-remifentanil-phosphorylation-of-glur1-receptors-in-the-anterior-cingulate-cortex
#7
Jie Zeng, Sisi Li, Chao Zhang, Guijin Huang, Cong Yu
The anterior cingulate cortex (ACC) plays a key role in regulating mood in animals, especially anxiety, and is also a brain region that is indispensable to pain perception. Postoperative anxiety is closely related to the experience of pain. Remifentanil is a commonly used surgical analgesic. The mechanism of supraspinal hyperalgesia caused by remifentanil remains unclear. We used animal models to simulate postoperative hyperalgesia and studied the GluR1 AMPA receptor subunit in the ACC using western blots and immunocytochemistry...
May 4, 2018: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/29725984/meta-analysis-of-the-association-between-gaba-receptor-polymorphisms-and-autism-spectrum-disorder-asd
#8
REVIEW
Manijeh Mahdavi, Majid Kheirollahi, Roya Riahi, Fariborz Khorvash, Mehdi Khorrami, Maryam Mirsafaie
Previous studies have reported the association of GABA receptor subunits B3, A5, and G3 single-nucleotide polymorphisms (SNPs) in chromosome 15q11-q13 with autism spectrum disorders (ASDs). However, the currently available results are inconsistent. This study aimed to investigate the association between ASD and the GABA receptor SNPs in chromosomal region 15q11-q13. The association was calculated by the overall odds ratio (OR) with a 95% confidence interval (CI). We used sensitivity analyses and the assessment of publication bias in our meta-analysis...
May 3, 2018: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/29717403/the-role-of-apolipoprotein-e-and-ethanol-exposure-in-age-related-changes-in-choline-acetyltransferase-and-brain-derived-neurotrophic-factor-expression-in-the-mouse-hippocampus
#9
Mostofa Jamal, Asuka Ito, Naoko Tanaka, Takanori Miki, Ayaka Takakura, Shingo Suzuki, Kiyoshi Ameno, Hiroshi Kinoshita
Disruption of apolipoprotein E (APOE) is responsible for age-dependent neurodegeneration and cognitive impairment. Elderly individuals are more sensitive than young individuals to the effects of ethanol (EtOH), particularly those affecting cognition. We investigated the role of APOE deficiency and EtOH exposure on age-dependent alterations in choline acetyltransferase (ChAT) and brain-derived neurotrophic factor (BDNF) mRNA and protein expression in the mouse hippocampus. Three-month-old (young) and 12-month-old (aged) ApoE-knockout (ApoE-KO) and wild-type (WT) mice were treated with saline or 2 g/kg EtOH, and the bilateral hippocampus was collected after 60 min for real-time PCR and western blotting analyses...
May 1, 2018: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/29713949/resveratrol-protects-purkinje-neurons-and-restores-muscle-activity-in-rat-model-of-cerebellar-ataxia
#10
Zeynab Ghorbani, Reza Mastery Farahani, Abbas Aliaghaei, Fariba Khodagholi, Gholam Houssein Meftahi, Samira Danyali, Mohammad Amin Abdollahifar, Mahtab Daftari, Mahdi Eskandarian Boroujeni, Yousef Sadeghi
Cerebellar ataxia (CA) is regarded as a miscellaneous cluster of brain disorders related to the cerebellum. Resveratrol is a naturally occurring polyphenolic compound. Previous reports suggest that resveratrol confers neuroprotection in various animal models of brain damage. Indeed, we considered it invaluable to investigate whether a treatment with resveratrol has a therapeutic role against CA induced by 3-acetylpyridine (3-AP) in rats. In addition, no investigation has examined neuroprotective effect of resveratrol in rat model of CA...
May 1, 2018: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/29713948/association-study-of-anril-genetic-variants-and-multiple-sclerosis
#11
Maryam Rezazadeh, Jalal Gharesouran, Mohsen Moradi, Rezvan Noroozi, Mir Davood Omrani, Mohammad Taheri, Soudeh Ghafouri-Fard
Multiple sclerosis (MS) is an autoimmune disorder of central nervous system with several genetic and environmental risk factors. Genes with regulatory roles on immune system have been implicated in its pathogenesis. Recently, long non-coding RNAs (lncRNAs) have been demonstrated to control some aspects of immune response. Among them is antisense non-coding RNA in the INK4 locus (ANRIL) whose involvement in NF-κB signaling pathway has been highlighted. In the current study, we evaluated the association between rs1333045, rs4977574, rs1333048, and rs10757278 variants of ANRIL and MS risk in a population of 410 Iranian MS patients and 410 healthy subjects...
April 30, 2018: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/29705934/exosomes-secreted-by-adipose-derived-stem-cells-contribute-to-angiogenesis-of-brain-microvascular-endothelial-cells-following-oxygen-glucose-deprivation-in-vitro-through-microrna-181b-trpm7-axis
#12
Yujia Yang, Yue Cai, Yuan Zhang, Juan Liu, Zhiqiang Xu
Adipose-derived stem cells (ADSCs) have been demonstrated to promote cerebral vascular remodeling processes after stroke. However, the exact molecular mechanism by which ADSCs exert protective roles in ischemic stroke is still poorly understood. In this study, we identified the role of exosomal microRNA-181b-5p (181b-Exos) in regulating post-stroke angiogenesis. The results of migration assay and capillary network formation assay showed that exosomes secreted by ADSCs (ADSCs-Exos) promoted the mobility and angiogenesis of brain microvascular endothelial cells (BMECs) after oxygen-glucose deprivation (OGD)...
April 29, 2018: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/29705933/mesenchymal-stem-cells-form-3d-clusters-following-intraventricular-transplantation
#13
Nicole Jungwirth, Laura Salinas Tejedor, Wen Jin, Viktoria Gudi, Thomas Skripuletz, Veronika Maria Stein, Andrea Tipold, Andrea Hoffmann, Martin Stangel, Wolfgang Baumgärtner, Florian Hansmann
Mesenchymal stem cells (MSCs) are regarded as an immune privileged cell type with numerous regeneration-promoting effects. The in vivo behavior of MSC and underlying mechanisms leading to their regenerative effects are largely unknown. The aims of this study were to comparatively investigate the in vivo behavior of canine (cMSC), human (hMSC), and murine MSC (mMSC) following intra-cerebroventricular transplantation. At 7 days post transplantation (dpt), clusters of cMSC, hMSC, and mMSC were detected within the ventricular system...
April 28, 2018: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/29700768/proteomic-analysis-of-cerebral-cortex-extracts-from-sus-scrofa-with-induced-hemorrhagic-stroke
#14
Alexander A Sidyakin, Anna L Kaysheva, Artur T Kopylov, Alexander V Lobanov, Sergei G Morozov
Cerebrovascular diseases, including stroke and micro stroke, are the main causes of death in contemporary society. Hemorrhagic stroke is the fast emerging defficiency in the brain function resulting from disturbance of blood supply to the brain caused by the rapture of blood vessels (Lopez et al. in Proteomics Clin Appl 6:190-200, 2012). The influence of a model hemorrhagic stroke on white pigs with the change in the protein profile of their cortical samples 24 h and 2 months after the stroke was examined using mass-spectrometric analysis...
April 26, 2018: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/29700767/effects-of-post-weaning-chronic-stress-on-nociception-spinal-cord-%C3%AE-opioid-and-%C3%AE-2-adrenergic-receptors-expression-in-rats-and-their-offspring
#15
Asef Hormozi, Asadollah Zarifkar, Mohsen Tatar, Mahdi Barazesh, Bahar Rostami
Stressful situations can change biological process in human and animal, and some of these changes may transfer to the next generations. We used a communication box to induce chronic electrical foot-shock stress in rats. Tail flick latency and formalin test were done to determine the level of pain sensation. Real-time RT-PCR was used to measure the level of spinal cord μ-opioid (MOR) and α2-adrenergic receptors (α2-AR) mRNA. We demonstrate that chronic stress can change nociception and leads to hyperalgesia...
April 26, 2018: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/29696468/microrna-21-confers-neuroprotection-against-cerebral-ischemia-reperfusion-injury-and-alleviates-blood-brain-barrier-disruption-in-rats-via-the-mapk-signaling-pathway
#16
Xiaofeng Yao, Yahui Wang, Dongya Zhang
The mechanism contributing to blood-brain barrier (BBB) disruption, involved in poststroke edema and hemorrhagic transformation, is important but elusive. We investigated microRNA-21 (miR-21)-mediated mechanism in the disruption of BBB following cerebral ischemia-reperfusion (I/R) injury. Rats with cerebral I/R injury were prepared after middle cerebral artery occlusion and subsequent reperfusion. The underlying regulatory mechanisms of miR-382 were investigated with treatment of miR-382 mimics, miR-382 inhibitors, or SB203580 (an inhibitor of the MAPK signaling pathway) prior to I/R modeling...
April 26, 2018: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/29680983/sertoli-cells-avert-neuroinflammation-induced-cell-death-and-improve-motor-function-and-striatal-atrophy-in-rat-model-of-huntington-disease
#17
Houssein Ahmadi, Mahdi Eskandarian Boroujeni, Yousef Sadeghi, Mohammad Amin Abdollahifar, Fariba Khodagholi, Gholam Houssein Meftahi, Mohammadmehdi Hadipour, Amir-Hossein Bayat, Fatemeh Shaerzadeh, Abbas Aliaghaei
Huntington's disease (HD) is a genetically heritable disorder, linked with continuing cell loss and degeneration mostly in the striatum. Currently, cell therapy approaches in HD have essentially been focused on replenishing or shielding cells lost over the period of the disease. Herein, we sought to explore the in vitro and in vivo efficacy of primary rat Sertoli cells (SCs) and their paracrine effect against oxidative stress with emphasis on HD. Initially, SCs were isolated and immunophenotypically characterized by positive expression of GATA4...
April 21, 2018: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/29623602/inhibition-of-astrocyte-connexin-43-channels-facilitates-the-differentiation-of-oligodendrocyte-precursor-cells-under-hypoxic-conditions-in-vitro
#18
Qiong Wang, Zhen Wang, Yeye Tian, Huaqiu Zhang, Yongkang Fang, Zhiyuan Yu, Wei Wang, Minjie Xie, Fengfei Ding
Oligodendrocyte precursor cells (OPCs) proliferation and differentiation are essential for remyelination after white matter injury. Astrocytes could promote oligodendrogenesis after white matter damage whereas the underlying mechanisms are unknown. In this study, the role of astrocytic connexin43 (Cx43) hemichannels involved in OPC proliferation and differentiation in chronic hypoxia was evaluated. In an astrocyte-OPC co-culture chronic hypoxia model, OPCs became proliferative but failed to mature into oligodendrocytes...
April 5, 2018: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/29589202/the-impact-of-five-vdr-polymorphisms-on-multiple-sclerosis-risk-and-progression-a-case-control-and-genotype-phenotype-study
#19
Pavel Křenek, Yvonne Benešová, Julie Bienertová-Vašků, Anna Vašků
Vitamin D receptor polymorphisms have been the target of many studies focusing on multiple sclerosis. However, previously reported results have been inconclusive. The objective of this study was to investigate the association between five vitamin D receptor polymorphisms (EcoRV, FokI, ApaI, TaqI, and BsmI) and multiple sclerosis susceptibility and its course. The study was carried out as a case-control and genotype-phenotype study, consisted of 296 Czech multiple sclerosis patients and 135 healthy controls...
March 28, 2018: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/29574664/wnt3a-ectopic-expression-interferes-axonal-projection-and-motor-neuron-positioning-during-the-chicken-spinal-cord-development
#20
Qiuling Li, Ciqing Yang, Bichao Zhang, Zhikun Guo, Juntang Lin
The formation of dorsal-ventral axis of the spinal cord is controlled largely by dorsal signals such as Wnts (which are members of the wingless + MMTV integrants, Int family), besides ventral signals such as sonic hedgehog (Shh). Wnt3a, one of the Wnt family members, is involved in multiple cellular functions, including self-renewal, proliferation, differentiation, and motility. Here, we aim to study the mechanism of the regulation of chicken spinal cord patterning by Wnt3a. In this study, Wnt3a was ectopically expressed in the spinal cord of developing chicken embryos by in ovo electroporation...
March 25, 2018: Journal of Molecular Neuroscience: MN
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