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Journal of Molecular Neuroscience: MN

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https://www.readbyqxmd.com/read/28634693/rhepo-enhances-cellular-anti-oxidant-capacity-to-protect-long-term-cultured-aging-primary-nerve-cells
#1
Huqing Wang, Jiaxin Fan, Mengyi Chen, Qingling Yao, Zhen Gao, Guilian Zhang, Haiqin Wu, Xiaorui Yu
Erythropoietin (EPO) may protect the nervous system of animals against aging damage, making it a potential anti-aging drug for the nervous system. However, experimental evidence from natural aging nerve cell models is lacking, and the efficacy of EPO and underlying mechanism of this effect warrant further study. Thus, the present study used long-term cultured primary nerve cells to successfully mimic the natural aging process of nerve cells. Starting on the 11th day of culture, cells were treated with different concentrations of recombinant human erythropoietin (rhEPO)...
June 21, 2017: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/28620838/modelling-fus-mislocalisation-in-an-in-vitro-model-of-innervated-human-muscle
#2
Sonja Prpar Mihevc, Mojca Pavlin, Simona Darovic, Marko Živin, Matej Podbregar, Boris Rogelj, Tomaz Mars
Degeneration of distal axons and neuromuscular junctions is an early feature in the pathology of amyotrophic lateral sclerosis (ALS), which culminates in motor neuron loss due to axon retraction and muscle atrophy. The complex interactions in the pathogenesis of ALS between motor neurons, muscle cells and accompanying glia require an appropriate experimental model. Here, we have defined a co-culture model based on human myotubes innervated by neurons from embryonic rat spinal cord explants to investigate the pathology and treatment of ALS...
June 15, 2017: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/28620837/retraction-note-to-nucleolin-promotes-tgf-%C3%AE-signaling-initiation-via-tgf-%C3%AE-receptor-i-in-glioblastoma
#3
Shunzeng Lv, Jie Zhang, Mingzhi Han, Weiping Wang, Ya Zhang, Dongxiao Zhuang, Ranran Shi, Ruixiang Bian, Chengjun Yao
No abstract text is available yet for this article.
June 15, 2017: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/28616777/differential-regulation-of-mecp2-phosphorylation-by-laminin-in-oligodendrocytes
#4
Zalak S Parikh, Ashutosh Tripathi, Prakash P Pillai
Oligodendrocytes (OLGs) are the myelinating cells of the central nervous system (CNS), and its proper differentiation is crucial for normal functioning of neurons. Methyl-CpG-binding protein 2 (MeCP2) is a multifunctional methylated DNA binding protein; mutation of which causes Rett syndrome, a severe neurodevelopmental disorder. Previously, we reported that MeCP2 is expressed in all the stages of oligodendrocyte development, and also shown the role of MeCP2 as a transcription regulator of myelin genes in OLGs...
June 14, 2017: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/28616776/evidence-towards-rna-binding-motif-rnp1-rrm-protein-3-rbm3-as-a-potential-biomarker-of-lithium-response-in-bipolar-disorder-patients
#5
Eleni Merkouri Papadima, Paola Niola, Carla Melis, Claudia Pisanu, Donatella Congiu, Cristiana Cruceanu, Juan Pablo Lopez, Gustavo Turecki, Raffaella Ardau, Giovanni Severino, Caterina Chillotti, Maria Del Zompo, Alessio Squassina
Lithium has been used for more than six decades for the management of bipolar disorder (BD). In a previous transcriptomic study, we showed that patients affected by either BD or cluster headache, both disorders characterized by circadian disturbances and response to lithium in a subgroup of patients, have higher expression of the RNA binding motif (RNP1, RRM) protein 3 (RBM3) gene compared to controls. To investigate whether RBM3 could represent a biomarker of lithium response, we screened raw microarray expression data from lymphoblastoid cell lines (LCLs) derived from 20 BD patients, responders or non-responders to lithium...
June 14, 2017: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/28601977/neuroglobin-protects-rats-from-sepsis-associated-encephalopathy-via-a-pi3k-akt-bax-dependent-mechanism
#6
Songyun Deng, Yuhang Ai, Hua Gong, Caixia Chen, Qianyi Peng, Li Huang, Long Wu, Lemeng Zhang, Lina Zhang
Sepsis-associated encephalopathy (SAE) is a common complication of sepsis, and has no generally accepted treatment due to its complicated pathophysiology. Previously, we demonstrated the protective role of neuroglobin (Ngb) in SAE rats, but the exact mechanism has not been determined. To investigate the potential neuroprotective roles and mechanisms of Ngb, Sprague-Dawley rats were used. Overexpression of Ngb via intracerebroventricular injection with Ngb plasmids attenuated brain damage assessed by hematoxylin and eosin (HE) staining and neurological dysfunction assessed by Morris water maze test...
June 10, 2017: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/28578517/phosphate-transporters-expression-in-patients-with-primary-familial-brain-calcifications
#7
L F Pimentel, R R Lemos, J R Oliveira
Primary familial brain calcification (PFBC), formerly known as Fahr disease, is a rare neurological disorder characterized by extensive calcification deposits in the brain. So far, four genes have been reported with variations associated with PFBC, SLC20A2, PDGFβ, PDGFRβ, and XPR1. Using real-time qPCR, we analyzed the expression of three inorganic phosphate (Pi) transporters (SLC20A1, SLC20A2, and XPR1) in patients with PFBC. Our results showed a significant reduction (~40%) of SLC20A2 expression in the patients carrying mutation whereas no significant change was observed within the patients without known mutations...
June 3, 2017: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/28577205/a-preliminary-study-ps1-increases-u1-snrna-expression-associated-with-ad
#8
Zhi Cheng, Zhanqiang Du, Yingchun Shang, Yuling Zhang, Tao Zhang
U1 small nuclear RNA (snRNA) is selectively enriched in 100% of familial Alzheimer's disease (AD) resulting from presenilin1 (PS1) and amyloid precursor protein (APP) mutations. However, it remains unknown what gene or protein cause the U1 snRNA overexpression and then resulted in AD. Using SH-SY5Y cells, we discovered that PS1 induced the overexpression of U1 snRNA, which increased the production of Aβ. Moreover, the U1 snRNA overexpression induced the upregulation of apoe and clu transcripts. In addition, the levels of phosphorylation of tau protein at Thr212 were significantly elevated in U1 snRNA overexpression cells...
June 3, 2017: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/28474151/alismol-a-sesquiterpenoid-isolated-from-vladimiria-souliei-suppresses-proinflammatory-mediators-in-lipopolysaccharide-stimulated-microglia
#9
Dongdong Shi, Xiaoqiang Song, Yuanqiang Guo, Jing Xu, Yu Liu, Jingling Zhang, Chun-Ai Cui, Da-Qing Jin
Microglia activation plays an important role in the pathogenesis of various neurodegenerative diseases by producing neurotoxic factors, such as proinflammatory cytokines and nitric oxide (NO); therefore, suppression of microglia activation is a potential therapeutic approach against these diseases. Previous study showed that alismol, a sesquiterpenoid isolated from the roots of Vladimiria souliei inhibits interferon-γ-induced NO production in murine macrophage RAW264.7 cells. In the present study, we found that alismol reduced NO and prostaglandin E2 (PGE2) levels and suppressed the expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) in lipopolysaccharide (LPS)-stimulated primary and cultured microglia...
May 4, 2017: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/28429234/neuron-to-neuron-transfer-of-fus-in-drosophila-primary-neuronal-culture-is-enhanced-by-als-associated-mutations
#10
Sébastien Feuillette, Morgane Delarue, Gaëtan Riou, Anne-Lise Gaffuri, Jane Wu, Zsolt Lenkei, Olivier Boyer, Thierry Frébourg, Dominique Campion, Magalie Lecourtois
The DNA- and RNA-binding protein fused in sarcoma (FUS) has been pathologically and genetically linked to amyotrophic lateral sclerosis (ALS) or frontotemporal lobar degeneration (FTLD). Cytoplasmic FUS-positive inclusions were identified in the brain and spinal cord of a subset of patients suffering with ALS/FTLD. An increasing number of reports suggest that FUS protein can behave in a prion-like manner. However, no neuropathological studies or experimental data were available regarding cell-to-cell spread of these pathological protein assemblies...
April 20, 2017: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/28401370/the-research-on-the-relationship-of-rage-lrp-1-and-a%C3%AE-accumulation-in-the-hippocampus-prefrontal-lobe-and-amygdala-of-stz-induced-diabetic-rats
#11
Lou-Yan Ma, Yu-Lang Fei, Xiao-Ye Wang, Song-Di Wu, Jun-Hui Du, Mei Zhu, Long Jin, Ming Li, Hai-Long Li, Jia-Jia Zhai, Lu-Peng Ji, Ran-Ran Ma, Song-Fang Liu, Mo Li, Li Ma, Xiao-Rui Ma, Qiu-Min Qu, Ya-Li Lv
Diabetes mellitus (DM) has been regarded as an important risk factor for Alzheimer's disease (AD), and diabetic patients and animals have shown cognitive dysfunction. More research has shown that the amyloid-β (Aβ), which is a hallmark of AD, was found deposited in the hippocampus of diabetic rats. This Aβ accumulation is regulated by the receptor for advanced glycation end products (RAGE) and low-density lipoprotein receptor-related protein (LRP-1). However, the expression of RAGE and LRP-1 in diabetic rats is not very clear...
April 11, 2017: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/28401369/the-importance-of-vegf-kdr-signaling-pathway-genes-should-not-be-ignored-when-the-risk-of-developing-multiple-sclerosis-is-taken-into-consideration
#12
Mehrdokht Mazdeh, Rezvan Noroozi, Jalal Gharesouran, Arezou Sayad, Alireza Komaki, Mohammad Mahdi Eftekharian, Mohsen Habibi, Mehdi Toghi, Mohammad Taheri
Vascular endothelial growth factor (VEGF) and its receptor kinase insert domain-containing receptor (KDR) pathway trigger the process of angiogenesis as well as inflammation, which contributes to the development and progression of demyelinating lesions in multiple sclerosis. This work is a case-control study comprising of a total of 400 subjects with multiple sclerosis and 400 healthy controls. Participants were subjected to neurological examination and peripheral blood sampling for genotyping. Polymorphisms in the VEGF and KDR genes were assessed using the restriction fragment length polymorphism (RFLP-PCR) method...
April 11, 2017: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/28401368/erratum-to-mir-9-5p-down-regulates-pit2-but-not-pit1-in-human-embryonic-kidney-293-cells
#13
D P Bezerra, M Keasey, J R M Oliveira
No abstract text is available yet for this article.
April 11, 2017: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/28386642/absence-of-carboxypeptidase-e-neurotrophic-factor-%C3%AE-1-in-knock-out-mice-leads-to-dysfunction-of-bdnf-trkb-signaling-in-hippocampus
#14
Lan Xiao, Su-Youne Chang, Zhi-Gang Xiong, Prabhuanand Selveraj, Y Peng Loh
Carboxypeptidase E (CPE), first discovered as a prohormone processing enzyme, has also now been shown to be a secreted neurotrophic factor (neurotrophic factor-α1, NF-α1) that acts extracellularly as a signaling molecule to mediate neuroprotection, cortical stem cell differentiation, and antidepressive-like behavior in mice. Since brain-derived neurotrophic factor (BDNF) has very similar trophic functions, and its processing from pro-BDNF involves intracellular sorting of pro-BDNF to the regulated secretory pathway by CPE acting as a sorting receptor, we investigated whether the lack of CPE/NF-α1 would affect BDNF-TrkB signaling in mice...
April 6, 2017: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/28378260/effect-of-metformin-on-adult-hippocampal-neurogenesis-comparison-with-donepezil-and-links-to-cognition
#15
Sara Ahmed, Zahra Mahmood, Aneela Javed, Shoaib Naiyer Hashmi, Inga Zerr, Saima Zafar, Saadia Zahid
Recent studies have uncovered evidence suggesting that interference with hippocampal adult neurogenesis contributes to neurodegeneration in Alzheimer's disease (AD). Evidence supporting that AD is a metabolic disease with derangements in brain glucose utilization implies the use of anti-diabetics as an alternate therapeutic strategy. The present study drew comparison between the pro-neurogenic potential of metformin and donepezil in AlCl3-induced mouse model of neurodegeneration. Morris water maze task and subsequent immunohistochemical evaluation for NeuN was conducted...
April 4, 2017: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/28364364/possible-reversal-of-ptsd-related-dna-methylation-by-sympathetic-blockade
#16
REVIEW
Eugene G Lipov, Kenneth Candido, Elspeth C Ritchie
Studies have shown that brain-derived neurotrophic factor (BDNF) level increase is associated with post-traumatic stress disorder (PTSD) risk. BDNF may be a "missing-link" that mediates the interaction between genetics, environment, and the sympathetic system. Trauma has been shown to induce DNA methylation that in turn can increase BDNF concentration due to increased gene expression. Therapies that focus on the reduction of beta-NGF (BNGF) levels may impact PTSD symptoms. The focus of this paper is to discuss possible effect of stellate ganglion block (SGB) on epigenetic changes noted with PTSD mediated by BDNF and NGF...
March 31, 2017: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/28343294/neuroprotective-role-of-exogenous-brain-derived-neurotrophic-factor-in-hypoxia-hypoglycemia-induced-hippocampal-neuron-injury-via-regulating-trkb-mir134-signaling
#17
Weidong Huang, Facai Meng, Jie Cao, Xiaobin Liu, Jie Zhang, Min Li
Hypoxic-ischemic brain injury is an important cause of neonatal mortality and morbidity. Brain-derived neurotrophic factor (BDNF) has been reported to play a neuroprotective role in hypoxic-ischemic brain injury; however, the specific effects and mechanism of BDNF on hypoxic-hypoglycemic hippocampal neuron injury remains unknown. The current study investigated the action of BDNF in regulating cerebral hypoxic-ischemic injury by simulating hippocampal neuron ischemia and hypoxia. We found that BDNF, p-Trkb, and miR-134 expression levels decreased, and that exogenous BDNF increased survival and reduced apoptosis in hypoxic-hypoglycemic hippocampal neurons...
March 26, 2017: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/28341893/single-prolonged-stress-induced-changes-in-autophagy-related-proteins-beclin-1-lc3-and-p62-in-the-medial-prefrontal-cortex-of-rats-with-post-traumatic-stress-disorder
#18
Shilei Zheng, Fang Han, Yuxiu Shi, Lili Wen, Dan Han
Autophagy, or type II programmed cell death, plays a crucial role in many nervous system diseases. However, few studies have examined the role of autophagy in post-traumatic stress disorder (PTSD), and the mechanisms underlying PTSD are poorly understood. The objective of this research was to explore the expression of three important autophagy-related proteins, Beclin-1, microtubule-associated protein 1 light chain 3 (LC3), and p62/SQSTM1 (p62), in the medial prefrontal cortex (mPFC) of an animal model of PTSD to identify changes in autophagic activity during PTSD pathogenesis...
March 25, 2017: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/28560687/hiv-1-gp120-upregulates-brain-derived-neurotrophic-factor-bdnf-expression-in-bv2-cells-via-the-wnt-%C3%AE-catenin-signaling-pathway
#19
Yongdi Wang, Jinxu Liao, Shao-Jun Tang, Jianhong Shu, Wenping Zhang
HIV-1 gp120 plays a critical role in the pathogenesis of HIV-associated pain, but the underlying molecular mechanisms are incompletely understood. This study aims to determine the effect and possible mechanism of HIV-1 gp120 on BDNF expression in BV2 cells (a murine-derived microglial cell line). We observed that gp120 (10 ng/ml) activated BV2 cells in cultures and upregulated proBDNF/mBDNF. Furthermore, gp120-treated BV2 also accumulated Wnt3a and β-catenin, suggesting the activation of the Wnt/β-catenin pathway...
June 2017: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/28540642/plasma-and-white-blood-cells-show-different-mirna-expression-profiles-in-parkinson-s-disease
#20
Christine Schwienbacher, Luisa Foco, Anne Picard, Eloina Corradi, Alice Serafin, Jörg Panzer, Stefano Zanigni, Hagen Blankenburg, Maurizio F Facheris, Giulia Giannini, Marika Falla, Pietro Cortelli, Peter P Pramstaller, Andrew A Hicks
Parkinson's disease (PD) diagnosis is based on the assessment of motor symptoms, which manifest when more than 50% of dopaminergic neurons are degenerated. To date, no validated biomarkers are available for the diagnosis of PD. The aims of the present study are to evaluate whether plasma and white blood cells (WBCs) are interchangeable biomarker sources and to identify circulating plasma-based microRNA (miRNA) biomarkers for an early detection of PD. We profiled plasma miRNA levels in 99 L-dopa-treated PD patients from two independent data collections, in ten drug-naïve PD patients, and in unaffected controls matched by sex and age...
June 2017: Journal of Molecular Neuroscience: MN
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