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Journal of Molecular Neuroscience: MN

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https://www.readbyqxmd.com/read/27909871/nap-interferes-with-hypoxia-inducible-factors-and-vegf-expression-in-retina-of-diabetic-rats
#1
Agata Grazia D'Amico, Grazia Maugeri, Claudio Bucolo, Salvatore Saccone, Concetta Federico, Sebastiano Cavallaro, Velia D'Agata
The retinal microvascular damage is a complication of diabetic retinopathy (DR). Hyperglycemia and hypoxia are responsible of aberrant vessel's proliferation. The cellular response to hypoxia is mediated through activation of hypoxia-inducible factors (HIFs). Among these, HIF-1α modulates expression of its target gene, VEGF, whose upregulation controls the angiogenic event during DR development. In a previous study, we have demonstrated that a small peptide, NAP, is able to protect retina from hyperglycemic insult...
December 1, 2016: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/27909870/erratum-to-evaluation-of-the-effect-of-nt-3-and-biodegradable-poly-l-lactic-acid-nanofiber-scaffolds-on-differentiation-of-rat-hair-follicle-stem-cells-into-neural-cells-in-vitro
#2
Fatemeh Moghani Ghoroghi, Leila Beygom Hejazian, Banafshe Esmaeilzade, Masumeh Dodel, Masoud Roudbari, Maliheh Nobakht
No abstract text is available yet for this article.
December 1, 2016: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/27905005/microrna-128-3p-protects-mouse-against-cerebral-ischemia-through-reducing-p38%C3%AE-mitogen-activated-protein-kinase-activity
#3
Guochao Mao, Pengyu Ren, Gang Wang, Feng Yan, Yuelin Zhang
The p38α, also named Mapk14, is a pro-apoptotic protein, which is reported to be downregulated 2 h after cerebral ischemia. However, little is known what causes the downregulation of p38α protein level. Here, we studied the effect of cerebral ischemia on p38α mRNA expression and p38α protein level in brain of mice. We found that p38α protein level is reduced after middle cerebral artery occlusion. However, at the meantime, p38α mRNA expression has no detectable changes, suggesting that the possible posttranscription is regulated by ischemia...
November 30, 2016: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/27888397/synaptosome-associated-protein-25-snap25-gene-association-analysis-revealed-risk-variants-for-asd-in-iranian-population
#4
Mohammad Reza Safari, Mir Davood Omrani, Rezvan Noroozi, Arezou Sayad, Shaghayegh Sarrafzadeh, Alireza Komaki, Fateme Asadzadeh Manjili, Mehrdokht Mazdeh, Ali Ghaleiha, Mohammad Taheri
Autism spectrum disorder (ASD) is a common, complex neurological condition, affecting approximately 1% of people worldwide. Monogenic neurodevelopmental disorders which showed autistic behavior patterns have suggested synaptic dysfunction, as a key mechanism in the pathophysiology of ASD. Subsequently, genes involved in synaptic signaling have been investigated with a priority for candidate gene studies. A synaptosomal-associated protein 25 (SNAP25) gene plays a crucial role in the central nervous system, contributing to exocytosis by targeting and fusion of vesicles to the cell membrane...
November 26, 2016: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/27888396/effects-of-administered-ethanol-and-methamphetamine-on-glial-glutamate-transporters-in-rat-striatum-and-hippocampus
#5
Fahad S Alshehri, Yusuf S Althobaiti, Youssef Sari
Exposure to ethanol (EtOH) or methamphetamine (MA) can lead to increase in extracellular glutamate concentration in the brain. Although studies from ours showed the effects of EtOH exposure on key glial glutamate transporters, little is known about the effects of sequential exposure to EtOH and MA or MA alone on certain glial glutamate transporters. In this study, we investigated the effects of sequential exposure to EtOH and MA on the expression of the major glutamate transporters, glutamate transporter 1 (GLT-1), as well as cystine/glutamate antiporter (xCT) and glutamate aspartate transporter (GLAST) in striatum and hippocampus...
November 25, 2016: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/27885529/lack-of-aquaporin-9-reduces-brain-angiogenesis-and-exaggerates-neuronal-loss-in-the-hippocampus-following-intracranial-hemorrhage-in-mice
#6
Weiyang Ji, Jing Wang, Jie Xu, Xudong Zhao, Xing Xu, Xiaojie Lu
Intracranial hemorrhage (ICH) is a common subtype of stroke with high morbidity and mortality. However, few clinical therapies that can reduce ICH-induced brain injury and promote the recovery outcome in ICH patients are available to improve the recovery from ICH. Given that aquaporin 9 (AQP9) plays a critical role in brain edema after ischemic stroke and traumatic brain injury and is involved in the regulation of angiogenesis, we examined the role of AQP9 in preventing neuronal loss and in neovascularization in the dorsal hippocampus (DH) after ICH...
November 24, 2016: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/27866326/the-neuroprotective-peptide-poly-arginine-12-r12-reduces-cell-surface-levels-of-nmda-nr2b-receptor-subunit-in-cortical-neurons-investigation-into-the-involvement-of-endocytic-mechanisms
#7
Gabriella MacDougall, Ryan S Anderton, Adam B Edwards, Neville W Knuckey, Bruno P Meloni
We have previously reported that cationic poly-arginine and arginine-rich cell-penetrating peptides display high-level neuroprotection and reduce calcium influx following in vitro excitotoxicity, as well as reduce brain injury in animal stroke models. Using the neuroprotective peptides poly-arginine R12 (R12) and the NR2B9c peptide fused to the arginine-rich carrier peptide TAT (TAT-NR2B9c; also known as NA-1), we investigated the mechanisms whereby poly-arginine and arginine-rich peptides reduce glutamate-induced excitotoxic calcium influx...
November 20, 2016: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/27866325/sexually-dimorphic-expression-of-reelin-in-the-brain-of-a-mouse-model-of-alzheimer-disease
#8
Giampiero Palladino, Vincenzina Nicolia, Gabor G Kovacs, Sonia Canterini, Viviana Ciraci, Andrea Fuso, Franco Mangia, Sigfrido Scarpa, Maria Teresa Fiorenza
Recent evidence highlights the protective role of reelin against amyloid β (Aβ)-induced synaptic dysfunction and cognitive impairment in Alzheimer disease (AD). In this study, exploiting TgCRND8 mice that overexpress a mutant form of amyloid β precursor protein (AβPP) and display an early onset of AD neuropathological signs, we addressed the question whether changes of reelin expression eventually precede the appearance of Aβ-plaques in a sex-dependent manner. We show that sex-associated and brain region-specific differences in reelin expression appear long before Aβ-plaque formation...
November 19, 2016: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/27864661/molecular-anti-inflammatory-mechanisms-of-retinoids-and-carotenoids-in-alzheimer-s-disease-a-review-of-current-evidence
#9
REVIEW
Niyaz Mohammadzadeh Honarvar, Ahmad Saedisomeolia, Mina Abdolahi, Amir Shayeganrad, Gholamreza Taheri Sangsari, Babak Hassanzadeh Rad, Gerald Muench
Alzheimer's disease (AD) is considered as one of the most prevalent neurodegenerative disorders characterized by progressive loss of mental function and ability to learn. AD is a multifactorial disorder. Various hypotheses are suggested for the pathophysiology of AD including "Aβ hypothesis," "tau hypothesis," and "cholinergic hypothesis." Recently, it has been demonstrated that neuroinflammation is involved in the pathogenesis of AD. Neuroinflammation causes synaptic dysfunction and neuronal death within the brain...
November 18, 2016: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/27838821/nfat5-protects-astrocytes-against-oxygen-glucose-serum-deprivation-restoration-damage-via-the-sirt1-nrf2-pathway
#10
Xun Xia, Bo Qu, Yun-Ming Li, Li-Bin Yang, Ke-Xia Fan, Hui Zheng, Hai-Dong Huang, Jian-Wen Gu, Yong-Qin Kuang, Yuan Ma
Nuclear factor of activated T cells (NFAT) is a multifunctional cytokine family. NFAT5 was recently reported to be involved in many neuronal functions, but its specific function remains unclear. In this study, our aim is to investigate whether NFAT5 overexpression can protect astrocytes against oxygen-glucose-serum deprivation/restoration (OGSD/R) damage. In vivo, rats were subjected to ischemia-reperfusion injury, resulting in increased water content, infarct volume, and expression of NFAT5 protein in rat spinal cord...
November 12, 2016: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/27826759/design-based-stereology-for-evaluation-of-histological-parameters
#11
Markus Kipp, Maren C Kiessling, Tanja Hochstrasser, Caroline Roggenkamp, Christoph Schmitz
Valid quantification of organ volume and total cell numbers are crucial parameters for morphometric studies. The number of a specific cell type cannot be simply deduced from the number of its profiles found in thin tissue sections, as this parameter also depends on cell volume, tissue orientation as well as tissue atrophy. Design-based stereology has become the method of choice for unbiased, reproducible total cell number quantification. Steps described in this protocol include transcardial perfusion of mice, postfixation, and cryoprotection of the region of interest (ROI), followed by the preparation of a systematically and randomly sampled series of thick sections through the entire ROI...
November 8, 2016: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/27815672/microrna-433-inhibits-the-proliferation-and-migration-of-huvecs-and-neurons-by-targeting-hypoxia-inducible-factor-1-alpha
#12
Lin Zhang, Yuanxiao Zhang, Xiaohua Zhang, Yan Zhang, Yi Jiang, Xinli Xiao, Jing Tan, Wei Yuan, Yong Liu
Emerging evidence has demonstrated an important role of microRNAs (miRNAs) in the pathogenesis of cerebral infarction. In the present study, a down-regulation of microRNA-433 (miR-433) is identified in hypoxia-induced human umbilical vein vascular endothelial cells (HUVECs) as well as in rat neurons, and is found to be negatively regulated cell proliferation and migration. Moreover, the expression of miR-433 is inversely correlated with the expression of hypoxia-inducible factor 1 alpha (HIF-1α), which has been shown to play critical role in responding to hypoxia conditions...
November 4, 2016: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/27812772/erratum-to-genetic-screening-of-pediatric-cavernous-malformations
#13
Elisa Merello, Marco Pavanello, Alessandro Consales, Samantha Mascelli, Alessandro Raso, Andrea Accogli, Armando Cama, Valeria Capra, Patrizia De Marco
No abstract text is available yet for this article.
November 3, 2016: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/27796870/gpr30-activation-contributes-to-the-puerarin-mediated-neuroprotection-in-mpp-induced-sh-sy5y-cell-death
#14
Yue-Fa Cheng, Guoqi Zhu, Qing-Wen Wu, Yue-Sheng Xie, Yan Jiang, Lan Guo, Ya-Li Guan, Ying-Shuo Liu, Jun Zhang
The neuroprotective action of puerarin in Parkinson's disease (PD) models has been well investigated. However, the mechanisms involved in protection have not been completely understood. G protein-coupled receptor 30 (GPR30) is a G protein-coupled estrogen receptor and considered a potential target in the neuroprotection against PD. In this study, we investigated whether puerarin prevented against 1-methyl-4-phenylpyridinium (MPP(+))-induced cell death via GPR30. Our results showed that the GPR30 agonist, G1, exhibited puerarin-mediated neuroprotection against MPP(+)-induced cell death of SH-SY5Y cells...
October 30, 2016: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/27796869/zinc-transporter-3-znt3-as-an-active-substance-in-the-enteric-nervous-system-of-the-porcine-esophagus
#15
Joanna Wojtkiewicz, Krystyna Makowska, Ewa Bejer-Olenska, Sławomir Gonkowski
Zinc transporter 3 (ZnT3), a member of the SLC 30 zinc transporter family, is involved in the transport of zinc ions from the cytoplasm into synaptic vesicles or intracellular organelles. The aim of the present study was to investigate for the first time the percentage of ZnT3-like immunoreactive (ZnT3-LI) neurons in the enteric nervous system (ENS) of the porcine esophagus and denotation of their neurochemical coding. Routine double- and triple-immunofluorescence labeling of cervical, thoracic, and abdominal fragments of esophagus for ZnT3 with protein gene product (PGP 9...
October 30, 2016: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/27796868/effect-of-rs11614913-polymorphism-on-mature-mir196a2-expression-and-its-target-gene-hoxc8-expression-in-human-glioma
#16
M K Sibin, S M Harshitha, K V L Narasingarao, I Bhat Dhananjaya, P Shukla Dhaval, G K Chetan
miRNA polymorphisms are recently identified as a risk factor for various cancers, and it is associated with change in the expression of target genes in vitro. rs11614913 polymorphism in miR196a2 was associated with risk of glioma in Chinese population. In this study, we have evaluated the role of rs11614913 polymorphism and glioma risk in Indian population in 180 cases and controls. Seventy-two glioma tissue-blood pairs were also assessed for mutation in this SNP. Further, the effect of this polymorphism on mature miR196a2 expression and HOXC8 gene expression was analysed in 33 glioma tissue samples with different genotypes...
October 28, 2016: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/27785757/stat3-controls-maturation-and-terminal-differentiation-in-mouse-hippocampal-neurons
#17
Xueling Ma, Yuyun Zhou, Yuan Chai, Xiaohe Wang, Xiaohui Huang
The hippocampus is an important region in the brain, responsible for learning, memory, and emotion. The hippocampus is composed of abundant neuronal cells, of which maturation is critical to physiological function and neural disease occurrence. Although the factors affecting neuronal maturation in the hippocampus has been widely studied, the specific mechanism involved in this process is still elusive to us. In the current study, Stat3 silencing and overexpression was achieved through lentivirus and adenovirus system...
October 26, 2016: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/27752929/mir-145-and-mir20a-5p-potentially-mediate-pleiotropic-effects-of-interferon-beta-through-mitogen-activated-protein-kinase-signaling-pathway-in-multiple-sclerosis-patients
#18
Naeim Ehtesham, Fariborz Khorvash, Majid Kheirollahi
MicroRNAs (miRNAs) are crucial to the immunopathogenesis of multiple sclerosis (MS). The mechanism of action of interferon beta (IFN-β) in relapsing-remitting (RR) MS patients is largely unknown. miR-145 and miR-20a-5p previously reported as diagnosis biomarker in treatment naïve RRMS patients and their expression after IFN-β therapy might be indicative of molecular mechanism of IFN-β. Cross-talking between JAK/STAT pathway and complementary pathways like MAPK is important in IFN-β signaling. Here, in order to clarify the ambiguous molecular mechanism of IFN-β and evaluate the potential use of them as a biomarker for monitoring of therapy, we investigated the expression of miR-145 and miR-20a-5p in blood sample of 15 treatment naïve RRMS patients, 15 IFN-β-treated RRMS patients, and 15 healthy volunteers (HVs)...
October 17, 2016: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/27752928/ghrelin-induced-enhancement-of-vasopressin-and-oxytocin-secretion-in-rat-neurohypophyseal-cell-cultures
#19
M Gálfi, M Radács, Zs Molnár, I Budai, G Tóth, A Pósa, K Kupai, Z Szalai, R Szabó, H A Molnár, J Gardi, Ferenc A László, Cs Varga
The effects of ghrelin on vasopressin and oxytocin secretion were studied in 13-14-day cell cultures of isolated rat neurohypophyseal tissue. The vasopressin and oxytocin contents of the supernatant were determined by radioimmunoassay after a 1- or 2-h incubation. Significantly increased levels of vasopressin and oxytocin production were detected in the cell culture media following ghrelin administration, depending on the ghrelin doses. The oxytocin level proved to be more elevated than that of vasopressin...
October 17, 2016: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/27730473/cytokine-profile-in-autism-spectrum-disorders-in-children
#20
Vesna Bryn, Hans Christian Dalsbotten Aass, Ola H Skjeldal, Jørn Isaksen, Ola Didrik Saugstad, Heidi Ormstad
The pathogenesis of autism spectrum disorders (ASD) is not completely understood, but there is evidence of associations with altered immune responses. The aim of this study was to determine the serum levels of various cytokines in children with ASD and in healthy controls, in order to determine their role in ASD and its diagnostic subgroups. Sixty-five ASD patients were enrolled from an epidemiological survey in Norway, of which 30 were diagnosed with childhood autism, 16 with Asperger syndrome, 12 with atypical autism, 1 with Rett syndrome, and 6 with another ASD diagnosis...
October 12, 2016: Journal of Molecular Neuroscience: MN
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