journal
MENU ▼
Read by QxMD icon Read
search

Experimental Physiology

journal
https://www.readbyqxmd.com/read/27897352/functional-magnetic-resonance-imaging-for-in-vivo-quantification-of-pulmonary-hypertension-in-the-sugen-5416-hypoxia-mouse
#1
Ellen C Breen, Miriam Scadeng, N Chin Lai, Fiona Murray, Timothy D Bigby
Pulmonary arterial hypertension (PAH) is characterized by elevated pulmonary artery pressures and right heart failure. PAH mouse models are instrumental in understanding disease pathophysiology. However, few methods are available to evaluate right cardiac function in small animals. In this study, magnetic resonance imaging (MRI) was used to measure in vivo cardiac dimensions in the Sugen 5416/hypoxia mouse model. Pulmonary hypertension (PH) was induced in C57BL/6 mice by three weeks of exposure to 10% oxygen and VEGF receptor inhibition (20 mg kg(-1) SU5416)...
November 29, 2016: Experimental Physiology
https://www.readbyqxmd.com/read/27859785/increased-monocyte-derived-reactive-oxygen-species-in-type-2-diabetes-role-of-endoplasmic-reticulum-stress
#2
Robert M Restaino, Shekhar H Deo, Alan R Parrish, Paul J Fadel, Jaume Padilla
Recent evidence suggests that exposure of human monocytes to glucolipotoxic media to mimic the composition of plasma of patients with type 2 diabetes (T2D) results in the induction of endoplasmic reticulum stress markers and formation of reactive oxygen species (ROS). The extent to which these findings translate to patients with T2D remains unclear. Thus, we first measured ROS (dihydroethidium fluorescence) in peripheral blood mononuclear cells (PBMCs) from whole blood of T2D patients (n = 8) and compared to age matched healthy controls (n = 8)...
November 18, 2016: Experimental Physiology
https://www.readbyqxmd.com/read/27859779/nicotinic-receptor-activation-augments-muscarinic-receptor-mediated-eccrine-sweating-but-not-cutaneous-vasodilatation-in-young-males
#3
Naoto Fujii, Jeffrey C Louie, Brendan D McNeely, Sarah Y Zhang, My-An Tran, Glen P Kenny
Acetylcholine released from cholinergic nerves can activate both muscarinic and nicotinic receptors; each is known to independently induce cutaneous vasodilatation and eccrine sweating in humans. However, it is not known whether the two receptors interact in order to mediate cutaneous vasodilatation and eccrine sweating. In ten young males (27 ± 6 years), cutaneous vascular conductance (CVC) and sweat rate were evaluated at intradermal microdialysis sites that were continuously perfused with either lactated Ringer (Control) or three different concentrations of nicotine (0...
November 18, 2016: Experimental Physiology
https://www.readbyqxmd.com/read/27859767/mechanisms-for-the-control-of-local-tissue-blood-flow-during-thermal-interventions-influence-of-temperature-dependent-atp-release-from-human-blood-and-endothelial-cells
#4
Kameljit K Kalsi, Scott T Chiesa, Steven J Trangmar, Leena Ali, Makrand D Lotlikar, José González-Alonso
Local tissue perfusion changes with alterations in temperature during heating and cooling, but the thermosensitivity of the vascular ATP signalling mechanisms for control of blood flow during thermal interventions remains unknown. Here we tested the hypotheses that the release of the vasodilator mediator ATP from human erythrocytes, but not from endothelial cells or other blood constituents, is sensitive to both increases and reductions in temperature and that increasing intravascular ATP availability with ATP infusion would potentiate thermal hyperaemia in limb tissues...
November 17, 2016: Experimental Physiology
https://www.readbyqxmd.com/read/27862525/mathematical-relationships-and-their-consequences-between-rat-pulse-waveform-parameters-and-blood-pressure-during-decreasing-no-bioavailability
#5
Anton Misak, Frantisek Kristek, Lenka Tomasova, Marian Grman, Elena Ondriasova, Olga Krizanova, Karol Ondrias
Information obtained from arterial pulse waveform (APW) is useful for characterization of cardiovascular system in particular (patho)physiological conditions. Our goal was to find out, if the relationship between rat APW parameters could be described by simple mathematical functions and find mathematical parameters for conditions of hypertension resulted from decreased NO bioavailability. Therefore, we explored details of 14 left carotid APW parameters of anesthetized male Wistar rats and mathematically characterized their relationship to systolic and diastolic blood pressure (BP) in the condition of gradual decrease of NO bioavailability after administration of L-NAME...
November 11, 2016: Experimental Physiology
https://www.readbyqxmd.com/read/27862484/%C3%AE-1-adrenoceptor-autoantibodies-increase-the-susceptibility-of-ventricular-arrhythmias-involving-abnormal-repolarization-in-guinea-pigs
#6
Yu-Hui Zhao, Hai-Xia Huang, Ping Liu, Yun-Hui Du, Peng Wang, Wen Wang, Ye Wu, Li Wang, Chang-Sheng Ma, Hui-Rong Liu
High titers of autoantibodies against the second extracellular loop of β1 -adrenergic receptors (β1 -AA) can be detected in the sera from patients with ventricular arrhythmias, but a causal relationship between β1 -AAs and ventricular arrhythmias has not been established. In this work, electrocardiograms of guinea pigs and isolated guinea pig hearts were recorded. Ventricular tachycardia (VT) and ventricular fibrillation (VF) were evoked by programmed electrical stimulation of the left ventricular epicardium of isolated guinea pig hearts...
November 11, 2016: Experimental Physiology
https://www.readbyqxmd.com/read/27862468/response-to-letter-from-tremblay-king-nirs-can-it-measure-conduit-artery-endothelial-function
#7
Kaitlin M McLay, Federico Y Fontana, Josh P Nederveen, Donald H Paterson, Silvia Pogliaghi, Juan M Murias
We thank Tremblay and King for their interest in our publication (McLay et al., 2016a), which has since been followed up with studies by McLay et al. (McLay et al., 2016c, 2016b). In these studies, it is suggested that the near-infrared spectroscopy (NIRS)-derived measure of tissue oxygen saturation (StO2 ), specifically the reperfusion rate (Slope 2) following a brief period of ischemia, can be easily applied as a reliable, non-invasive measure of vascular reactivity (McLay et al., 2016a, 2016c, 2016b)...
November 11, 2016: Experimental Physiology
https://www.readbyqxmd.com/read/27859929/does-attenuated-skin-blood-flow-lower-sweat-rate-and-the-critical-environmental-limit-for-heat-balance-during-severe-heat-exposure
#8
Matthew N Cramer, Daniel Gagnon, Craig G Crandall, Ollie Jay
Attenuated skin blood flow (SkBF) is often assumed to impair core temperature (Tc ) regulation. Profound pharmacologically-induced reductions in SkBF (∼85%) lead to impaired sweating but whether the smaller attenuations in SkBF (∼20%) more associated with ageing and certain diseases lead to decrements in sweating and maximum heat loss potential is unknown. Seven healthy males (28 ± 4y) completed a 30-min equilibration period at 41°C and a vapour pressure (Pa ) of 2.57 kPa followed by incremental steps in Pa of 0...
November 11, 2016: Experimental Physiology
https://www.readbyqxmd.com/read/27859912/sweating-responses-to-isometric-handgrip-exercise-and-forearm-muscle-metaboreflex-in-prepubertal-children-and-elderly
#9
Tatsuro Amano, Seiko Kai, Michi Nakajima, Tomoko Ichinose-Kuwahara, Nicola Gerrett, Narihiko Kondo, Yoshimitsu Inoue
The purpose of the present study is to investigate sweating responses to isometric handgrip (IH) exercise and muscle metaboreflex in prepubertal children and the elderly. In hot condition (ambient temperature, 35°C; relative humidity, 45%), 13 healthy young adults, 10 prepubertal children, and 10 elderly (age: 20.4±1.2, 11.4±0.5, and 63.5±3.1 years, respectively) repeated three handgrip-exercise protocol that consisted of 1 min IH exercise at 15, 30, or 45% of maximum voluntary contractions (MVC) followed by 2 min post-exercise forearm occlusion...
November 11, 2016: Experimental Physiology
https://www.readbyqxmd.com/read/27859807/putative-tissue-location-and-function-of-the-slc5-family-member-sglt3
#10
Matúš Soták, Joanne Marks, Robert Unwin
Sodium glucose transporter 3 (SGLT3) has attracted interest because of its putative role as a glucose sensor, rather than a sugar transporter, in contrast to its SGLT1 and SGLT2 co-family members. Significant progress has been made in characterizing the electrophysiological properties in vitro of the single human SGLT3 isoform and the two mouse isoforms, SGLT3a and SGLT3b. Although early reports indicated SGLT3 expression in the small intestinal myenteric and submucosal neurones, hypothalamic neurones, portal vein, and kidney, a lack of reliable antibodies has left unanswered its exact tissue and cellular localization...
November 11, 2016: Experimental Physiology
https://www.readbyqxmd.com/read/27859777/investigation-of-oxidative-stress-parameters-in-different-life-span-erythrocyte-fractions-in-young-untrained-men-after-an-acute-exercise
#11
Krzysztof Gwozdzinski, Anna Pieniazek, Sabina Tabaczar, Anna Jegier, Joanna Brzeszczynska
The objective of study was to establish the role of exercise-induced oxidative stress in the erythrocyte fractions: young (YF), middle-aged (MAF) and old (OF) of young untrained men after acute exercise. Blood samples were collected before exercise, immediately and one hour after exercise. Maximum wattage was 292±27 W and exercise time duration was 8.73±0.9 min. Different optical properties and oxidative stress parameters were found in each erythrocyte fraction. Total thiols in YF and MAF after exercise and after one hour rest were similar to values before exercise, however, in OF (32...
November 10, 2016: Experimental Physiology
https://www.readbyqxmd.com/read/27808439/hippocampal-subareas-arranged-in-the-dorsal-ventral-axis-modulate-cardiac-baroreflex-function-in-a-site-dependent-manner-in-rats
#12
Nilson Carlos Ferreira-Junior, Davi Campos Lagatta, Denise Resende Fabri, Fernando Henrique Ferrari Alves, Fernando Morgan Aguiar Corrêa, Leonardo Barbosa Moraes Resstel
From a neuroanatomical point of view, we may split the hippocampal formation into the dorsal (DH) and ventral (VH) hippocampus. Although the basic intrinsic circuitry of the hippocampus seems to be maintained throughout its longitudinal axis, dorsal and ventral portions connect differently with cortical and subcortical areas and express different gene patterns, being functionally distinct. Differential stimulation of the DH or VH can evoke either an increase or a decrease in blood pressure (BP), heart rate (HR) and sympathetic activity...
November 3, 2016: Experimental Physiology
https://www.readbyqxmd.com/read/27808438/warm-hands-cold-heart-progressive-whole-body-cooling-increases-warm-thermosensitivity-of-human-hands-and-feet-in-a-dose-dependent-fashion
#13
Davide Filingeri, Nathan B Morris, Ollie Jay
While inhibitory/facilitatory central modulation of vision and pain has been investigated, contextual modulation of skin temperature integration has been unexplored. Hence, we tested whether progressive decreases in whole-body mean skin temperature (Tsk ) (a large conditioning stimulus) alter the magnitude estimation of local warming and cooling stimuli applied to hairy and glabrous skin. On 4 separate occasions, 8 males (27 ± 5y) underwent a 30-min whole-body cooling protocol (water-perfused-suit; temperature: 5 C), during which a quantitative thermosensory test, consisting of reporting perceived magnitude of warming and cooling stimuli (±8°C from 30°C baseline) applied to the hand (palm/dorsum) and foot (sole/dorsum), was performed before cooling and every 10 min thereafter...
November 3, 2016: Experimental Physiology
https://www.readbyqxmd.com/read/27808433/adaptation-of-exercise-induced-stress-in-well-trained-healthy-young-men
#14
Lonneke M JanssenDuijghuijsen, Jaap Keijer, Marco Mensink, Kaatje Lenaerts, Lars Ridder, Stefan Nierkens, Shirley W Kartaram, Martie C M Verschuren, Raymond H H Pieters, Richard Bas, Renger F Witkamp, Harry J Wichers, Klaske van Norren
Strenuous exercise induces different stress-related physiological changes, potentially including changes in intestinal barrier function. In the Protégé Study (ISRCTN14236739; www.isrctn.com) we determined the test-retest repeatability in responses to exercise in well-trained individuals. Eleven well-trained males (27 ± 4 years old) completed an exercise protocol that consisted of intensive cycling intervals, followed by an overnight fast and an additional 90 min cycling phase at 50% Wmax the next morning...
November 3, 2016: Experimental Physiology
https://www.readbyqxmd.com/read/27790765/acupuncture-does-not-restore-metabolic-disturbances-in-the-p450-aromatase-inhibitor-induced-polycystic-ovary-syndrome-rat-model
#15
Manuel Maliqueo, Anna Benrick, Rodrigo Rodrigues Marcondes, Julia Johansson, Miao Sun, Elisabet Stener-Victorin
Low-frequency electroacupuncture restores sex steroid synthesis and sympathetic activity in women with polycystic ovary syndrome, which may improve its metabolic disturbances likely by modulating sympathetic nerve activity or sex steroid synthesis. We investigated whether low-frequency electroacupuncture regulates the metabolic function to the same extent as treatment with estradiol or β-adrenergic blocking in a rat model of polycystic ovary syndrome induced by a P450 aromatase inhibitor (letrozole). Letrozole (200 μg per day) or placebo pellets were implanted in pre-pubertal Wistar rats...
October 28, 2016: Experimental Physiology
https://www.readbyqxmd.com/read/27763697/changes-in-cardiovascular-responses-to-chemoreflex-activation-of-rats-recovered-from-protein-restriction-are-not-related-to-at1-receptors
#16
Renato Willian Martins Sá, Andrea Siqueira Haibara, Paula Magalhães Gomes, Giovana Lopes Aguiar, Rafael Souza Leopoldino Nascimento, Maria Lucia Pedrosa, Andréia Carvalho Alzamora, Lisandra Brandino de Oliveira, Leonardo Máximo Cardoso
What is the central question of this study? In this study we sought to investigate whether cardiovascular responses to peripheral chemoreflex activation of rats recovered from protein restriction are related to AT1 receptors activation. What is the main finding and its importance? This study highlights the fact that angiotensinergic mechanisms activated by AT1 receptors do not supported increased responses to peripheral chemoreflex activation by KCN in rats recovered from protein restriction. Also, we found that protein restriction led to increased resting ventilation in adult rats, even after recovery...
October 20, 2016: Experimental Physiology
https://www.readbyqxmd.com/read/27750401/response-to-letter
#17
Carsten Lundby, Paul Robach
The aim with any review is to summarize an expert's assessment of the literature where readers benefit from the reviewers overview and evaluation of the validity and applicability of individual studies. Millet and co-workers are of the opinion that our review (Lundby and Robach, 2016) is selective and that their studies are not fully and accurately represented in it. The reason for not including some of their studies is that we believe them to be flawed and we disagree that the studies we do cite are misinterpreted...
October 17, 2016: Experimental Physiology
https://www.readbyqxmd.com/read/27750391/clarification-on-altitude-training
#18
Grégoire P Millet, Franck Brocherie, Raphael Faiss, Olivier Girard
The authors report that many LHTL studies in normobaric hypoxia (NH) "failed to show a positive outcome", which in our view is only partially true. In a cross-over design, we (Saugy et al. 2016) recently tested if LHTL in hypobaric hypoxia (HH) would lead to larger performance enhancement than in NH. Our hypothesis was that HH (i.e. natural altitude) would lead to larger enhancement than NH but the results were contrary to this hypothesis. So we cannot support the affirmation by Lundby & Robach that "natural altitude remains the best approach"...
October 17, 2016: Experimental Physiology
https://www.readbyqxmd.com/read/27748983/moderate-intensity-endurance-training-improves-endothelial-glycocalyx-layer-in-healthy-young-men
#19
Joanna Majerczak, Marcin Grandys, Krzysztof Duda, Agnieszka Zakrzewska, Aneta Balcerczyk, Leszek Kolodziejski, Dorota Szymoniak-Chochol, Ryszard T Smolenski, Grzegorz Bartosz, Stefan Chlopicki, Jerzy A Zoladz
In this study we have evaluated the effect of 20-weeks of moderate-intensity endurance training (ET) on the endothelial glycocalyx layer integrity in relation to the training-induced changes in antioxidant defence. Eleven healthy young, untrained men performed an incremental cycling exercise until exhaustion before and after 20 weeks of ET. Endurance training consisted of 40- minute sessions, mainly of moderate-intensity (∼50% of VO2max ), performed 4 times per week. Venous blood samples were taken at rest and at the end of the maximal exercise test...
October 17, 2016: Experimental Physiology
https://www.readbyqxmd.com/read/27730694/acylcarnitines-as-markers-of-exercise-associated-fuel-partitioning-xenometabolism-and-potential-signals-to-muscle-afferent-neurons
#20
Jie Zhang, Alan R Light, Charles L Hoppel, Caitlin Campbell, Carol J Chandler, Dustin J Burnett, Elaine C Souza, Gretchen A Casazza, Ronald W Hughen, Nancy L Keim, John W Newman, Gary R Hunter, Jose R Fernandez, W Timothy Garvey, Mary-Ellen Harper, Oliver Fiehn, Sean H Adams
With insulin-resistance or type 2 diabetes mellitus, mismatches between mitochondrial fatty acid fuel delivery and oxidative phosphorylation/tricarboxylic acid cycle activity may contribute to inordinate accumulation of short- or medium-chain acylcarnitine fatty acid derivatives (markers of incomplete long-chain fatty acid oxidation [FAO]). We reasoned that incomplete FAO in muscle would be ameliorated concurrent with improved insulin sensitivity and fitness following a ∼14 wk training and weight loss intervention in obese, sedentary, insulin-resistant women...
October 12, 2016: Experimental Physiology
journal
journal
30375
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"