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European Archives of Oto-rhino-laryngology

Jae-Gu Cho, Hyung Kwon Byeon, Kyung Ho Oh, Seung-Kuk Baek, Soon-Young Kwon, Kwang-Yoon Jung, Jeong-Soo Woo
PURPOSE: Most tumors have obvious biologically active fibroblasts known variously as myofibroblasts or cancer-associated fibroblasts (CAFs) in the stroma. CAFs have been known as an important factor of cancer invasion and metastasis. This study aimed to investigate the presence of CAFs in patients with papillary thyroid carcinoma (PTC) and evaluate the correlation between CAFs and cervical lymph node (LN) metastasis in PTC through immunohistochemistry. METHODS: The medical records of 128 patients who were diagnosed with PTC from January 1, 2010 to December 31, 2010 were reviewed, and 78 patients who underwent total thyroidectomy with or without neck dissection, were included in this study...
July 17, 2018: European Archives of Oto-rhino-laryngology
Anna Nogués-Sabaté, Francesc Xavier Aviles-Jurado, Laura Ruiz-Sevilla, Eduardo Lehrer, Alfonso Santamaría-Gadea, Meritxell Valls-Mateus, Isabel Vilaseca
BACKGROUND: Narrow band imaging (NBI) in combination with white light endoscopy (WLE) has improved the accuracy for the diagnosis and follow-up of head and neck carcinomas by identifying changes in the vascular patterns of the mucosa. However, NBI evaluation is explorer-dependent and may be influenced by the learning curve. The aim of this study is to assess the intra and interobserver agreement of NBI and WLE at the office, under local anaesthesia, by either experienced or non-experienced observers...
July 17, 2018: European Archives of Oto-rhino-laryngology
Violeta Necula, Marcel Cosgarea, Alma Aurelia Maniu
PURPOSE: The role of cochlear implant in deaf children development is well-known. However, the results are highly variable and depend on several factors. The most important role belongs to the family, family environment in which the child develops. The aim of the study was to evaluate the features of the family environment in which cochlear-implanted children develop. METHODS: The questionnaire "Family Environment Scale" was sent to 108 families who had cochlear-implanted child with more than 6 months of experience...
July 17, 2018: European Archives of Oto-rhino-laryngology
Andréia Melchiors Wenzel, Cláudia Schweiger, Denise Manica, Leo Sekine, Isabel Cristina Schütz Ferreira, Gabriel Kuhl, Paulo José Cauduro Marostica
PURPOSE: To assess the impact of balloon laryngoplasty on clinical and surgical outcomes in pediatric patients with acute subglottic stenosis. METHODS: Two case series were included and compared. The first group included patients treated initially either with tracheostomy (if severe symptoms) or with close follow-up (if mild symptoms). Those children underwent re-evaluation and specific treatment of their stenosis with laser incisions or open surgeries some weeks later...
July 14, 2018: European Archives of Oto-rhino-laryngology
Marcel Sauvalle, Andrés Alvo
BACKGROUND: The respiratory epithelium is mainly constituted by caliciform (produces mucus, responsible of keeping moisture and trapping particles) and ciliated cells (transports mucus into the pharynx, by the movement of multiple cilia). For centuries, nasal lavages have been used for different rhinosinusal conditions. Some studies suggest not only a direct effect on the mobilisation of secretions, but also an improvement in mucociliary clearance rates. To our knowledge, the impact of temperature in nasal lavages has been scarcely studied...
July 13, 2018: European Archives of Oto-rhino-laryngology
Tary Yin, Marie Jardine, Anna Miles, Jacqui Allen
PURPOSE: Structural and functional pharyngeal changes occur with age. How these affect swallowing in healthy older adults is not well defined. This study presents quantitative pharyngeal anatomic features in healthy adults using videofluoroscopic study of swallowing (VFSS). This will help our understanding of the normal changes in swallowing that occur with age and illustrate what may constitute normal variation compared with abnormal swallow function. METHODS: 138 mixed gender adults with no history of dysphagia were recruited and underwent a standardized VFSS protocol...
July 12, 2018: European Archives of Oto-rhino-laryngology
Jefferson da Rocha Tenório, Leorik Pereira da Silva, Marília Gabriela de Aguiar Xavier, Thalita Santana, George João Ferreira do Nascimento, Ana Paula Veras Sobral
PURPOSE: Salivary gland tumors are complex and have a great histomorphological diversity; more than 30 histological subtypes are currently described and the study of proteins that help understand and differentiate these tumors is essential. We aimed to analyze the immunoexpression of cyclooxygenase-2 (COX-2) and cyclin D1 proteins in pleomorphic adenomas (PA), mucoepidermoid carcinomas (MEC) and adenoid cystic carcinomas (AdCC) of salivary glands. METHODS: A total of 38 PA, 12 AdCC and 12 MEC underwent immunohistochemical study by the polymeric biotin-free technique...
July 12, 2018: European Archives of Oto-rhino-laryngology
Masoumeh Faghani, Parvaneh Keshavars, Alireza Sharafshah, Babak Pourgholamali, Farshad Moharami, Shadman Nemati
Nasal Polyposis (NP) is a complex multi-factorial disease; associated with several environmental, genetic and inflammatory factors. TNF-alpha is one of the major pro-inflammatory cytokines involved in NP pathogenesis. Some of the polymorphisms of this gene affect its expression. Therefore, the aim of this study was to evaluate the polymorphism of TNF-alpha G/A308 gene and its association with nasal polyposis in north part of Iran. In this case-control study, 60 patients with NP and 75 healthy individuals referred to Guilan University hospital were evaluated...
July 12, 2018: European Archives of Oto-rhino-laryngology
Nicolien A van der Poel, Maarten P Mourits, Maartje M L de Win, Jonathan M Coutinho, Frederik G Dikkers
PURPOSE: Septic cavernous sinus thrombosis (CST) is a rare complication of infections in the head and neck area. CST is notorious for its bad prognosis, with high mortality and morbidity rates described in literature. However, these rates are based on old series. We question whether the prognosis of CST is currently still as devastating. The primary purpose of this study is to assess the mortality and morbidity of CST. METHODS: Using the databases of all relevant specialties in our tertiary referral hospital, we collected all the patients treated for CST in the period 2005-2017...
July 11, 2018: European Archives of Oto-rhino-laryngology
Yasser W Khafagy, Ahmed M Abd Elfattah, Waleed Moneir, Eman H Salem
BACKGROUND: Spontaneous CSF leak is a challenging condition, with frequent recurrences following attempted surgical closure. The selection of graft materials depends on the experience of the operating surgeon. Leukocyte- and platelet-rich fibrin (L-PRF) is a second-generation platelet concentrate that has currently invaded every surgical specialty. To our knowledge, no previous reports about the use of L-PRF in repair of CSF leak were published. The study was conducted to assess the potential role of L-PRF in spontaneous CSF leaks repair...
July 7, 2018: European Archives of Oto-rhino-laryngology
Ilaria Carmignani, Luca Giovanni Locatello, Isacco Desideri, Pierluigi Bonomo, Emanuela Olmetto, Lorenzo Livi, Odile Le Saec, Salvatore Coscarelli, Giuditta Mannelli
OBJECTIVES: Swallowing and voice dysfunctions are common side effects following head-and-neck squamous-cell carcinoma (HNSCC) treatment. Our aim was to analyze the relationships between quality of life, swallowing, and phonatory problems in patients with an advanced-stage HNSCC and to prospectively evaluate the effects of a prophylactic swallowing program. METHODS: First, we retrospectively studied 60 advanced HNSCC patients treated with exclusive or adjuvant radiotherapy/chemoradiotherapy (RT/CRT)...
July 5, 2018: European Archives of Oto-rhino-laryngology
Vincenzo Vincenti, Filippo Di Lella, Maurizio Falcioni, Maurizio Negri, Diego Zanetti
OBJECTIVE: To report neuroradiologic findings, surgical strategies and clinical and audiological results in a series of children with CHARGE syndrome (CS) who had been evaluated for cochlear implantation (CI). STUDY DESIGN: Retrospective case series. SETTING: Tertiary referral university hospital. PATIENTS: Eight profoundly deafened children with CS were included. Routine audiometric measurements, speech perception categories and speech intelligibility ratings were performed pre- and post-operatively...
July 3, 2018: European Archives of Oto-rhino-laryngology
Gao Ma, Liu-Ning Zhu, Guo-Yi Su, Hao Hu, Wen Qian, Shou-Shan Bu, Xiao-Quan Xu, Fei-Yun Wu
PURPOSE: To evaluate the diagnostic performance of histogram parameters derived from diffusion-weighted imaging (DWI) for differentiating malignant from benign parotid gland tumors compared with that of hotspot region of interest (ROI)-based apparent diffusion coefficient (ADC) measurement. METHODS: Our study retrospectively enrolled 60 patients with parotid gland tumors who had undergone DWI scan for pre-treatment evaluation. ADC measurements were performed using hotspot ROI (ADCHS-ROI )-based and histogram-based approach...
July 2, 2018: European Archives of Oto-rhino-laryngology
Guy Andry, Marc Hamoir, C René Leemans
PURPOSE: Quality assurance is much more difficult to achieve in surgical oncology than in medical oncology and radiotherapy where doses are standardized and toxicities are well-classified. To better define what is required in surgery, we analyzed recent articles addressing the point in head and neck surgery. RESULTS: The surgical report should match with the pathological description of the resected specimen with accurate delineation of the margins, number and level(s) of lymph nodes (capsular rupture if any)...
June 29, 2018: European Archives of Oto-rhino-laryngology
Sudhir Vasudevan Nair, Manish Mair, Noopur Sawarkar, Swagnik Chakrabarti, Burhanuddin Qayyumi, Deepa Nair, Pankaj Chaturvedi, Tejpal Gupta, Jai Prakash Agrawal
OBJECTIVE: The main objective is to compare the oncologic outcomes of patients with T3 laryngeal cancers who underwent total laryngectomy or organ preservation protocol (OPP) as the initial plan of management. MATERIALS AND METHODS: This is a retrospective study on 120 patients treated for T3 laryngeal and hypopharyngeal cancers. Patients with functional larynx underwent OPP and dysfunctional larynx underwent upfront laryngectomy. Median follow-up of the patients was 4...
June 29, 2018: European Archives of Oto-rhino-laryngology
Dragana D Božić, Bojan Pavlović, Jovica Milovanović, Ana Jotić, Jelena Čolović, Ivana Ćirković
PURPOSE: Microbial biofilms have been implicated in the pathogenesis of chronic rhinosinusitis with nasal polyposis (CRSwNP). The aim of our study was to evaluate in vitro effects of amoxicillin-clavulanic acid and levofloxacin on biofilm formation by bacterial species isolated from sinus tissue in patients with CRSwNP. METHODS: The sinus mucosal specimens were harvested from the upper parts and roof of ethmoid cavity of 48 patients with CRSwNP. Each sample was washed thoroughly in three separate beakers of sterile saline to remove any planktonic bacteria and further subjected to microbiology analysis...
June 29, 2018: European Archives of Oto-rhino-laryngology
Xiao-Dong Zhang, Zhong-Hua Li, Zhi-Sheng Wu, Wen Lin, Wen-Ji Lin, Jin-Chao Lin, Li-Ming Zhuang
PURPOSE: A novel precision three-dimensional (3D)-printed paranasal sinus-skull base anatomical model was generated with a commercial grade desktop 3D printer. A specific page-turning pattern was employed in this model, to display the internal spatial structure of the paranasal sinus. METHODS: The CT image data of paranasal sinus were imported into the Mimics software to construct a 3D digital paranasal sinus-skull base model. Then, the model was sliced in the coronal position and loaded into the 3D printer to print each slice of the paranasal sinus-skull base model at a ratio of 1:1 in size...
June 29, 2018: European Archives of Oto-rhino-laryngology
Pieter D de Veij Mestdagh, Marcel C J Jonker, Wouter V Vogel, Willem H Schreuder, Maarten L Donswijk, W Martin C Klop, Abrahim Al-Mamgani
PURPOSE: To investigate the feasibility of lymph drainage mapping (LDM) using SPECT/CT to help select head and neck cancer (HNSCC) patients for unilateral elective neck irradiation (ENI). Patients with lateralized HNSCC treated with radiotherapy routinely undergo bilateral ENI, despite the incidence of contralateral regional failure being relatively low even after unilateral ENI. We hypothesized that patients with a lateralized tumor without visible lymph drainage to the contralateral neck have an extremely low risk of contralateral involved nodes...
June 28, 2018: European Archives of Oto-rhino-laryngology
Xueyang Yang, Yifang Hu, He Shi, Chengzhou Zhang, Zhixiao Wang, Xiaoyun Liu, Huanhuan Chen, Lijuan Zhang, Dai Cui
OBJECTIVE: The study aimed to explore some novel diagnostic biomarkers for papillary thyroid carcinoma (PTC) by identifying the different expression of TROP-2, SLP-2 and CD56 in benign and malignant thyroid lesions. METHODS: We evaluated the mRNA expressions of TROP-2 and SLP-2 in fine needle aspirates (FNAs) which contained 10 PTCs and 10 benign follicular adenomas (FAs) using quantitative real-time PCR (qRT-PCR). Immunohistochemical (IHC) staining of TROP-2, SLP-2 and CD56 was also performed on postoperative samples of 30 PTCs and 29 FAs...
June 27, 2018: European Archives of Oto-rhino-laryngology
Esther Guiu Hernandez, Kristin Gozdzikowska, Richard Jones, Maggie-Lee Huckabee
BACKGROUND: Notable differences have been identified between low-resolution manometry (LRM) and high-resolution manometry (HRM) in normative data. OBJECTIVE: This study aimed to investigate within-subject differences between unidirectional LRM and circumferential HRM solid-state measurement sensors in the pharyngoesophageal segment during swallowing. METHODS: Ten healthy subjects (mean 26.9 years) were evaluated with both a 2.10 mm unidirectional catheter and a 2...
June 26, 2018: European Archives of Oto-rhino-laryngology
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