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European Archives of Oto-rhino-laryngology

Attila Óvári, Christoph Heckeler, Karsten Ehrt, Hans-Edgar Bernd, Hans-Wilhelm Pau, Albrecht Eiber
PURPOSE: Surgical manipulation with application of inappropriate force may damage middle ear structures leading to hearing loss. This work analyzes the forces applied in simulated otosurgical exercises in a laboratory set-up by measuring the spatial components of applied forces with objective assessment criteria. With these criteria, the individual force characteristics applied by the surgeon can be quantified and an objective feedback can be given about their surgical maneuvers. METHODS: A natural size model of the human incus was mounted on a load cell to measure the spatial forces in all three directions during different manipulation tasks performed under the microscope by ten surgeons from our department having different levels of experience in otosurgery...
November 8, 2018: European Archives of Oto-rhino-laryngology
José Miguel Villacampa Aubá, Alvaro Sánchez Barrueco, Gonzalo Díaz Tapia, Jessica Mireya Santillán Coello, Diego Armando Escobar Montatixe, Fernando González Galán, Ignacio Mahillo Fernández, Rocío González Márquez, Carlos Cenjor Español
BACKGROUND: Septal perforations consist in an anatomic defect of the mucosal, cartilaginous and/or bone tissues of the nasal septum. A huge variety of approaches and techniques for nasal perforation repair have been reported. METHODOLOGY/PRINCIPAL: Between January 2008 and January 2017, 38 patients were treated for nasal septal perforation in Department of Otorhinolaryngology Head and Neck Surgery, Fundación Jiménez Díaz University Hospital, Madrid, Spain. A novel approach is presented based on microscope...
November 7, 2018: European Archives of Oto-rhino-laryngology
Akshat Malik, Aseem Mishra, Prashant Chopda, Hitesh Singhvi, Sudhir Nair, Deepa Nair, Sarbani Ghosh Laskar, Kumar Prabhash, Jai Prakash Agarwal, Pankaj Chaturvedi
INTRODUCTION: In this study we have tried to analyze the impact of age on various clinico-pathological parameters, treatment completion and subsequent survival in older patients. MATERIALS AND METHODS: This is a retrospective analysis of 140 elderly (> 65 years) patients of oral cancer operated between January 2012 and December 2013. The patients were divided into two groups based upon their age that ≤ 70 years and > 70 years.Association of distribution of various clinico-pathological factors between different groups was assessed by using Chi-square test...
November 7, 2018: European Archives of Oto-rhino-laryngology
Megumi Koizumi, Miho Ishimaru, Hiroki Matsui, Kiyohide Fushimi, Tatsuya Yamasoba, Hideo Yasunaga
PURPOSE: Although post-tonsillectomy hemorrhage occurs rarely, it can be life-threatening. Previous studies showed that tranexamic acid (TXA) had insignificant association with the rate of post-tonsillectomy hemorrhage, but those findings were limited by small sample sizes. The purpose of this study was to examine the effectiveness of TXA in preventing post-tonsillectomy hemorrhage using nationwide database. METHODS: Data of a retrospective cohort of 117,598 patients from 750 hospitals, who had undergone tonsillectomy between 2010 and 2016, were drawn from the Diagnosis Procedure Combination database in Japan and studied...
November 7, 2018: European Archives of Oto-rhino-laryngology
Jan Löhler, Barbara Wollenberg
Electronic cigarettes (EC) with and without nicotine are used by more and more consumers within the last decade. The long-term risks of vapor inhalation are unknown. This study should describe the state of the art of knowledge with respect to the following four items: (1) ingredients of the vapor and their potential risks, the influence of EC on smoking of combustible tobacco to (2) adults and (3) the youth, and (4) the side effects of passive vaping. The vapor of EC contains, in comparison to tobacco smoke, less harmful substances, qualitatively and quantitatively...
November 3, 2018: European Archives of Oto-rhino-laryngology
Saime Sagiroglu, Adem Doganer
No abstract text is available yet for this article.
November 2, 2018: European Archives of Oto-rhino-laryngology
Anupam Mishra, Riddhi Jaiswal, Pandey Amita, S C Mishra
BACKGROUND: The molecular profile of juvenile nasopharyngeal angiofibroma (JNA) is extremely variable. In absence of established molecular signature the molecular targeting seems difficult for this heterogeneous disease. To establish a basic molecular signature, this paper analyses the interaction of 7 markers according to their ranks as per the decreasing scale of molecular expression. MATERIALS AND METHODS: Fourteen samples of JNA were obtained following surgical excision and mRNA expressions were established through real-time polymerase chain reaction (RT-PCR) for vasculoendothelial growth factor (VEGF), fibroblastic growth factor (FGF), c-Kit, c-myc, Ras, platelet-derived growth factor (PDGF) and tumor suppressor gene p53...
November 1, 2018: European Archives of Oto-rhino-laryngology
Ali Alkhars, Moumainn Abouzayd, Charles-Edouard Rouf, Hubert Lardy, David Bakhos, Soizick Pondaven-Letourmy, Sylvain Moriniere, Emmanuel Lescanne
OBJECTIVES: The main objective of this study is to report our experience in a university hospital in the surgical management of thyroid disease in pediatric patients. We also aim to analyze the results and evaluate the efficacy of fine-needle aspiration biopsy (FNAB) and frozen section analysis. METHODS: A retrospective review of thyroid surgeries from January 1997 to December 2017 was conducted. Patients aged under 18 who underwent total or partial thyroidectomy were included...
October 31, 2018: European Archives of Oto-rhino-laryngology
Abdurrahman Bugra Cengiz, Cemal Ozyilmaz, Alper Tabaru, Serkan Kayabasi, Sertug Sinan Ege, Sedat Ruzgar, Funda Emre, Mehmet Faruk Oktay
BACKGROUND: We aimed to investigate the effect of systemic isotretinoin therapy on normal and wounded nasal septal mucosa histopathologically in an experimental rabbit model. METHODS: Circular mucosal defect with a 7 mm diameter was made in the left septum of 12 New Zealand white rabbits. The rabbits were divided into two groups (six rabbits in each group) oral isotretinoin was given with olive oil at the operation day to the first group. The control group was only oil given group...
October 31, 2018: European Archives of Oto-rhino-laryngology
Urs Borner, Lukas Anschuetz, Nadine Kaiser, Alexander Rieke, Patrick Dubach, Marco Caversaccio
OBJECTIVE: The clinical challenge in blunt nasal trauma in children, is to identify cases requiring specialized care among frequently encountered banalities, whilst trying to minimize the exposure to diagnostic procedures. We aim to evaluate the related diagnostic and therapeutic pathways and its outcome during follow-up. METHODS: This retrospective cohort study includes children up to 16 years presenting at the emergency department with blunt nasal trauma of our tertiary reference center...
October 31, 2018: European Archives of Oto-rhino-laryngology
Neşe Asal, Nuray Bayar Muluk, Mikail Inal, Mehmet Hamdi Şahan, Adil Doğan, Sadiye Visal Buturak
OBJECTIVES: In the present study, we investigated olfactory bulb (OB) volume and olfactory sulcus (OS) depth of the psychotic patients (predominantly schizophrenia) and patients with anxiety disorder/depression. METHODS: This study was conducted retrospectively. Group 1 consisted of 30 psychotic patients (predominantly schizophrenia) (19 males and 11 females). Group 2 consisted of 37 patients with anxiety disorder/depression (10 males, 27 females). Group 3 consisted of 30 non-psychotic and non-anxiety disorder/depression subjects (9 males and 21 females)...
October 31, 2018: European Archives of Oto-rhino-laryngology
Nasser M Altamami, Sandra Zaouche, Delphine Vertu-Ciolino
INTRODUCTION: The aim of our study is to compare the functional results between two surgical techniques for reanimation of facial paralysis: hypoglossal-to-facial versus masseteric-to-facial nerve anastomosis. METHODS: This is a retrospective study of 13 patients treated for complete facial paralysis in two medical tertiary centers. The patients were classified into two groups. First group: masseteric-to-facial nerve anastomosis. Second group: hypoglossofacial nerve anastomosis...
October 30, 2018: European Archives of Oto-rhino-laryngology
Selda Kargin Kaytez, Ali Kavuzlu, Nihat Yumusak, Ramazan Oçal, Ozlem Akkoca
OBJECTIVES: In this study, our aim was to identify the possible effects of montelukast sodium (ML) on the prevention of experimentally induced myringosclerosis. MATERIALS AND METHODS: Twenty-eight female Wistar albino rats were used and they were divided into four groups randomly. Tympanic membranes (TM) of all animals were perforated and then group 1 received no treatment (control group), group 2 was treated with a topical saline solution, group 3 received topically ML and group 4 received orally ML...
October 30, 2018: European Archives of Oto-rhino-laryngology
Tamer A Mesallam, Medhat Yousef, Ayna Almasaad
BACKGROUND: Cochlear implantation (CI) in children with additional disabilities can be a fundamental and supportive intervention. Although, there may be some positive impacts of CI on children with multiple disabilities such as better outcomes of communication skills, development, and quality of life, the families of those children complain from the post-implant habilitation efforts that considered as a burden. OBJECTIVE: To investigate the outcomes of CI children with different co-disabilities through using the Meaningful Auditory Integration Scale (MAIS) and the Meaningful Use of Speech Scale (MUSS) as outcome measurement tools...
October 27, 2018: European Archives of Oto-rhino-laryngology
Tianni Xu, Wei Zhu, Ping Wang
PURPOSE: We conducted a meta-analysis assessing the association between the p.P240L (c.C719T) variant and the risk of nonsyndromic hearing loss (NSHL). METHODS: Literatures that reported prevalence rates were identified using PubMed, EMBASE, OVID, Cochrane library, Web of Science, Chinese National Knowledge Infrastructure, Wanfang Databases for the period from inception to August 2017. Random and fixed effects models were used to generate pooled ORs and I2 values...
October 26, 2018: European Archives of Oto-rhino-laryngology
Karla Flaviana Carneiro Castelo Branco, Andre Luis Ribeiro Ribeiro, Raíssa Pinheiro de Mendonça, João de Jesus Viana Pinheiro, Maria Sueli da Silva Kataoka, Maria Vanda Catão Arnaud, Sérgio de Melo Alves Junior
PURPOSE: Adenoid cystic carcinoma (ACC) is an intriguing lesion because it shows a slow growth in the beginning, but a late poor prognosis due to perineural invasion, metastasis and recurrence. This study aimed to investigate whether Akt signaling would be deregulated in adenoid cystic carcinoma and its consequence in the expression of associated proteins. METHODS: The expression of the Akt, p-Akt, NFκB, β-catenin, cyclin D1 and COX-2 was assessed by immunohistochemistry in 10 cases of ACC, 17 cases of pleomorphic adenoma (PA), and 7 cases of normal salivary gland (NSG)...
October 26, 2018: European Archives of Oto-rhino-laryngology
Xiuxiu Liu, Zhiyan Jiang, Zhen Xiao, Yonghong Jiang, Wen Li, Binbin Xu, Jing Ma, Chaoqun Zhang, Xiao Li, Yan Lin, Xiufeng Chen
OBJECTIVE: To evaluate the efficacy and safety of Chinese medicine in the treatment of adenoid hypertrophy in children. METHOD: Screening standard articles, extracting relevant data from meta-analysis, were analyzed by Revman5.1 software, by searching PubMed, Medline, VIP, Wan Fang and Chinese HowNet database 2006-2016 in traditional Chinese medicine treatment of children with adenoid literature. RESULTS: 206 articles met the inclusion criteria, of which ten were selected and included in the meta-analysis, and there were 803 patients...
October 25, 2018: European Archives of Oto-rhino-laryngology
Valéria Souza Freitas, Jean Nunes Dos Santos, Pedro Paulo de Andrade Santos, Cassiano Francisco Weege Nonaka, Leão Pereira Pinto, Lélia Batista de Souza
PURPOSE: To compare the immunohistochemical expression of matrix metalloproteinases-2, -7, -9 and -26 and tissue inhibitors of metalloproteinases-1 and -2 in pleomorphic adenomas and adenoid cystic carcinomas of the minor salivary glands. METHODS: Twenty cases of pleomorphic adenomas and 20 cases of adenoid cystic carcinomas were evaluated for the immunohistochemical expression of matrix metalloproteinases-2, -7, -9, and -26 and tissue inhibitors-1 and -2 in tumor parenchyma...
October 25, 2018: European Archives of Oto-rhino-laryngology
Paola Vincenza Sartori, Alberto Maria Saibene, Ennio Leopaldi, Marco Boniardi, Edoardo Beretta, Samuele Colombo, Emanuela Morenghi, Juliana Pauna, Loredana De Pasquale
PURPOSE: Intraoperative PTH testing (IOPTH) in treatment of primary hyperparathyroidism (PH) is debated. Some authors advise against IOPTH in patients with concordant preoperative imaging undergoing focused parathyroidectomy. This study aims to compare focused parathyroidectomy success rates with and without IOPTH in patients with concordant preoperative imaging. METHODS: Retrospective cohort study involving 599 consecutive patients underwent surgery for PH from 2012 to 2017...
October 24, 2018: European Archives of Oto-rhino-laryngology
Lin Lin, Jinjin Wei, Zheng Chen, Xinyue Tang, Fei Dai, Guangbin Sun
OBJECTIVE: Chronic rhinosinusitis (CRS) is a complicated disease with several variants caused by different cellular and molecular mechanisms. The characterization of this heterogeneity supports the definition that the disease consists of many endotypes, such as eosinophilic and neutrophilic CRS, and so on. This study aimed to explore group 2 innate lymphoid cells (ILC2s) in neutrophilic CRS without nasal polyps (CRSsNP) and with nasal polyps (CRSwNP), and evaluate ILC2s across characteristics of the disease...
October 24, 2018: European Archives of Oto-rhino-laryngology
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