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Clinical Oncology: a Journal of the Royal College of Radiologists

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https://www.readbyqxmd.com/read/30415785/anal-cancer-putting-health-related-quality-of-life-at-the-forefront
#1
EDITORIAL
S C Sodergren, A Gilbert, A-S Darlington, V Vassiliou
No abstract text is available yet for this article.
November 8, 2018: Clinical Oncology: a Journal of the Royal College of Radiologists
https://www.readbyqxmd.com/read/30415784/hypofractionated-concomitant-chemoradiation-in-inoperable-locally-advanced-non-small-cell-lung-cancer-a-report-on-100-patients-and-a-systematic-review
#2
M S Iqbal, G Vashisht, R McMenemin, P Atherton, F McDonald, T Simmons, A Bradshaw, J Kovarik, H Turnbull, L Dodd, A Greystoke, P Mulvenna
AIMS: Concomitant chemoradiation is the standard of care in patients with inoperable non-small cell lung cancer. The purpose of this study was to analyse the survival outcome and toxicity data of using hypofractionated chemoradiation. MATERIALS AND METHODS: One hundred patients were treated from June 2011 to November 2016. Treatment consisted of 55 Gy in 20 daily fractions concurrently with split-dose cisplatin vinorelbine chemotherapy over 4 weeks followed by two cycles of cisplatin vinorelbine only...
November 8, 2018: Clinical Oncology: a Journal of the Royal College of Radiologists
https://www.readbyqxmd.com/read/30409563/cross-sectional-study-of-temozolomide-induced-chemotherapy-induced-nausea-and-vomiting-in-patients-with-glioma
#3
LETTER
M Malhotra, A Chandrasekahran, R Tonse, R Jalali, V M Patil
No abstract text is available yet for this article.
November 5, 2018: Clinical Oncology: a Journal of the Royal College of Radiologists
https://www.readbyqxmd.com/read/30392896/turning-crisis-into-opportunity-a-local-approach-beyond-tasters-and-coasters
#4
LETTER
X Y Jiang, F E McDonald
No abstract text is available yet for this article.
November 1, 2018: Clinical Oncology: a Journal of the Royal College of Radiologists
https://www.readbyqxmd.com/read/30389262/pathologically-node-positive-prostate-carcinoma-prevalence-pattern-of-care-and-outcome-from-a-population-based-study
#5
S Roy, M Sia, S Tyldesley, G Bahl
AIMS: To evaluate the prevalence, patterns of care and outcome of pathologically node-positive (pN+) prostate cancer (P-Ca) after radical prostatectomy from a provincial population database. PATIENTS AND METHODS: Patients were identified from a provincial cancer registry and a genitourinary cancer outcomes unit (2005-2014). Of a total of 4723 patients who underwent radical prostatectomy, 167 patients with pN+ P-Ca were identified (28/2181 from 2005-2007 and 139/2542 from 2010-2014)...
October 30, 2018: Clinical Oncology: a Journal of the Royal College of Radiologists
https://www.readbyqxmd.com/read/30389261/genetic-variants-predict-optimal-timing-of-radiotherapy-to-reduce-side-effects-in-breast-cancer-patients
#6
K Johnson, J Chang-Claude, A-M Critchley, C Kyriacou, S Lavers, T Rattay, P Seibold, A Webb, C West, R P Symonds, C J Talbot
AIMS: Radiotherapy is an important treatment for many types of cancer, but a minority of patients suffer long-term side-effects of treatment. Multiple lines of evidence suggest a role for circadian rhythm in the development of radiotherapy late side-effects. MATERIALS AND METHODS: We carried out a study to examine the effect of radiotherapy timing in two breast cancer patient cohorts. The retrospective LeND cohort comprised 535 patients scored for late effects using the Late Effects of Normal Tissue-Subjective Objective Management Analytical (LENT-SOMA) scale...
October 30, 2018: Clinical Oncology: a Journal of the Royal College of Radiologists
https://www.readbyqxmd.com/read/30385006/the-human-papillomavirus-as-a-common-pathogen-in-oropharyngeal-anal-and-cervical-cancers
#7
S Otter, S Whitaker, J Chatterjee, A Stewart
The burden of human papillomavirus (HPV)-related cancers worldwide is significant. Although the incidence of cervical cancer is decreasing due to cervical screening programmes, the incidences of oropharyngeal, anal and vulval cancers are increasing. The introduction of HPV vaccination programmes in many countries has had an impact on HPV infection rates but due to the time-lag from initial HPV infection to the development of invasive carcinoma, the impact on the incidence of HPV-related cancer will take more time to become evident...
October 29, 2018: Clinical Oncology: a Journal of the Royal College of Radiologists
https://www.readbyqxmd.com/read/30385005/re-irradiation-for-paediatric-tumours
#8
D S Tsang, N J Laperriere
Despite best available therapy, many children with cancer develop recurrence after multimodal treatment, including initial radiation therapy. Re-irradiation is defined as the use of a second course of radiation therapy with a retreatment volume that overlaps substantially with that of a previously delivered course of radiation therapy. Re-irradiation is an important part of salvage treatment for patients with recurrent ependymoma, diffuse intrinsic pontine glioma, medulloblastoma and germinoma. In patients with ependymoma, conventionally fractionated re-irradiation (1...
October 29, 2018: Clinical Oncology: a Journal of the Royal College of Radiologists
https://www.readbyqxmd.com/read/30361128/adopting-advanced-radiotherapy-techniques-in-the-treatment-of-paediatric-extracranial-malignancies-challenges-and-future-directions
#9
N A Lavan, F H Saran, U Oelfke, H C Mandeville
Geometric uncertainties in radiotherapy are conventionally addressed by defining a safety margin around the radiotherapy target. Misappropriation of such margins could result in disease recurrence from geometric miss or unnecessary irradiation of normal tissue. Numerous quantitative organ motion studies in adults have been published, but the first paediatric-specific studies were only published in recent years. In the very near future, intensity-modulated proton beam therapy and magnetic resonance-guided radiotherapy will be clinically implemented in the UK...
October 22, 2018: Clinical Oncology: a Journal of the Royal College of Radiologists
https://www.readbyqxmd.com/read/30352721/barriers-to-referral-for-palliative-radiotherapy-by-physicians-a-systematic-review
#10
J Livergant, M Howard, J Klein
AIMS: Palliative radiotherapy (PRT) can relieve symptoms and improve quality of life, but remains underutilised, possibly due to lack of referrals. We conducted a systematic review to study barriers impeding referral for PRT. MATERIALS AND METHODS: We searched EMBASE and MEDLINE to identify published studies of physician barriers to PRT referral. Data were synthesised using the percentage of respondents to the surveys in these studies who identified a given factor as a significant barrier to PRT referral...
October 20, 2018: Clinical Oncology: a Journal of the Royal College of Radiologists
https://www.readbyqxmd.com/read/30322681/an-audit-for-radiotherapy-planning-and-treatment-errors-from-a-low-middle-income-country-centre
#11
J P Agarwal, R Krishnatry, G Panda, R Pathak, C Vartak, R A Kinhikar, S James, S V Khobrekar, S K Shrivastava, A K D'Cruz, D D Deshpande
AIMS: To report the findings of an audit for radiotherapy errors from a low-middle-income country (LMICs) centre. This would serve as baseline data for radiotherapy error rates, their severity and causes, in such centres where modern error reporting and learning processes still do not exist. MATERIALS AND METHODS: A planned cross-sectional weekly audit of electronic radiotherapy charts at the radiotherapy planning and delivery step for all patients treated with curative intent was conducted...
October 12, 2018: Clinical Oncology: a Journal of the Royal College of Radiologists
https://www.readbyqxmd.com/read/30301591/science-in-focus-the-microbiome-and-cancer-therapy
#12
EDITORIAL
J L Alexander, D Kohoutova, N Powell
No abstract text is available yet for this article.
October 6, 2018: Clinical Oncology: a Journal of the Royal College of Radiologists
https://www.readbyqxmd.com/read/30297164/analysis-of-a-national-programme-for-selective-internal-radiation-therapy-for-colorectal-cancer-liver-metastases
#13
J White, G Carolan-Rees, M Dale, H E Morgan, H E Patrick, T C See, E L Beeton, D E B Swinson, J K Bell, D M Manas, A Crellin, N J Slevin, R A Sharma
AIMS: Patients with chemotherapy-refractory colorectal cancer liver metastases have limited therapeutic options. Selective internal radiation therapy (SIRT) delivers yttrium 90 microspheres as a minimally invasive procedure. This prospective, single-arm, observational, service-evaluation study was part of National Health Service England Commissioning through Evaluation. METHODS: Patients eligible for treatment had histologically confirmed carcinoma with liver-only/liver-dominant metastases with clinical progression during or following oxaliplatin-based and irinotecan-based chemotherapy...
October 5, 2018: Clinical Oncology: a Journal of the Royal College of Radiologists
https://www.readbyqxmd.com/read/30279038/radiological-kinetics-of-brain-metastases-and-clinical-implications-for-patients-treated-with-stereotactic-radiosurgery
#14
L W Nicholls, M B Pinkham, A Bernard, R Lusk, T Watkins, B Hall, S Olson, M C Foote
AIMS: Select patients with brain metastases receive stereotactic radiosurgery (SRS) with the objective of improving survival and intracranial disease control. Brain metastases number and volume are prognostic factors used to inform patient selection. The aim of this study was to assess the rate of change of brain metastases size and number (growth kinetics) between the diagnostic and day of SRS magnetic resonance imaging (MRI) scans. MATERIALS AND METHODS: All patients treated with Gamma Knife SRS between October 2015 and April 2017 were included in this single-centre retrospective analysis...
September 29, 2018: Clinical Oncology: a Journal of the Royal College of Radiologists
https://www.readbyqxmd.com/read/30274767/evaluation-of-response-to-stereotactic-radiosurgery-in-brain-metastases-using-multiparametric-magnetic-resonance-imaging-and-a-review-of-the-literature
#15
V Sawlani, N Davies, M Patel, R Flintham, C Fong, G Heyes, G Cruickshank, N Steven, A Peet, A Hartley, H Benghiat, S Meade, P Sanghera
AIMS: Following stereotactic radiosurgery (SRS), brain metastases initially increase in size in up to a third of cases, suggesting treatment failure. Current imaging using structural magnetic resonance imaging (MRI) cannot differentiate between tumour recurrence and SRS-induced changes, creating difficulties with patient management. Combining multiparametric MRI techniques, which assess tissue physiological and metabolic information, has shown promise in answering this clinical question...
September 28, 2018: Clinical Oncology: a Journal of the Royal College of Radiologists
https://www.readbyqxmd.com/read/30274766/outcomes-for-patients-with-non-metastatic-triple-negative-breast-cancer-in-new-zealand
#16
M James, A Dixit, B Robinson, C Frampton, V Davey
AIMS: Triple-negative breast cancer (TNBC) has inferior outcomes to other subtypes of breast cancer. We studied the demographics and baseline breast cancer characteristics of patients in New Zealand with TNBC and assessed survival outcomes and prognostic/predictive factors. MATERIALS AND METHODS: We searched the New Zealand breast cancer registry database and identified patients with TNBC without distant metastatic disease. We retrieved demographic, tumour characteristic and treatment information...
September 28, 2018: Clinical Oncology: a Journal of the Royal College of Radiologists
https://www.readbyqxmd.com/read/30244830/magnetic-resonance-imaging-only-workflow-for-radiotherapy-simulation-and-planning-in-prostate-cancer
#17
L G W Kerkmeijer, M Maspero, G J Meijer, J R N van der Voort van Zyp, H C J de Boer, C A T van den Berg
Magnetic resonance imaging (MRI) is often combined with computed tomography (CT) in prostate radiotherapy to optimise delineation of the target and organs-at-risk (OAR) while maintaining accurate dose calculation. Such a dual-modality workflow requires two separate imaging sessions, and it has some fundamental and logistical drawbacks. Due to the availability of new MRI hardware and software solutions, CT examinations can be omitted for prostate radiotherapy simulations. All information for treatment planning, including electron density maps and bony anatomy, can nowadays be obtained with MRI...
September 20, 2018: Clinical Oncology: a Journal of the Royal College of Radiologists
https://www.readbyqxmd.com/read/30236641/the-import-low-trial-collaborative-research-accelerates-practice-change-in-breast-radiotherapy
#18
EDITORIAL
A M Kirby, I S Bhattacharya, M Wilcox, J S Haviland
No abstract text is available yet for this article.
September 17, 2018: Clinical Oncology: a Journal of the Royal College of Radiologists
https://www.readbyqxmd.com/read/30224203/delivering-functional-imaging-on-the-mri-linac-current-challenges-and-potential-solutions
#19
A Datta, M C Aznar, M Dubec, G J M Parker, J P B O'Connor
Magnetic resonance imaging (MRI) is a highly versatile imaging modality that can be used to measure features of the tumour microenvironment including cell death, proliferation, metabolism, angiogenesis, and hypoxia. Mapping and quantifying these pathophysiological features has the potential to alter the use of adaptive radiotherapy planning. Although these methods are available for use on diagnostic machines, several challenges exist for implementing these functional MRI methods on the MRI-linear accelerators (linacs)...
September 14, 2018: Clinical Oncology: a Journal of the Royal College of Radiologists
https://www.readbyqxmd.com/read/30209010/the-potential-value-of-mri-in-external-beam-radiotherapy-for-cervical-cancer
#20
A Cree, J Livsey, L Barraclough, M Dubec, T Hambrock, M Van Herk, A Choudhury, A McWilliam
The reference standard treatment for cervical cancer is concurrent chemoradiotherapy followed by magnetic resonance imaging (MRI)-guided brachytherapy. Improvements in brachytherapy have increased local control rates, but late toxicity remains high with rates of 11% grade ≥3. The primary clinical target volume (CTV) for external-beam radiotherapy includes the cervix and uterus, which can show significant inter-fraction motion. This means that generous margins are required to cover the primary CTV, increasing the radiation dose to organs at risk and, therefore, toxicity...
September 9, 2018: Clinical Oncology: a Journal of the Royal College of Radiologists
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