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Clinical Oncology: a Journal of the Royal College of Radiologists

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https://www.readbyqxmd.com/read/28094086/differentiated-and-medullary-thyroid-cancer-surgical-management-of-cervical-lymph-nodes
#1
P Asimakopoulos, I J Nixon, A R Shaha
Thyroid cancer metastasises to the central and lateral compartments of the neck frequently and early. The impact of nodal metastases on outcome is affected by the histological subtype of the primary tumour and the patient's age, as well as the size, number and location of those metastases. The impact of extranodal extension has recently been highlighted as an important prognosticating factor. Although clinically evident nodal disease in the lateral neck compartments has a significant impact on both survival and recurrence, microscopic metastases to the central or the lateral neck in well-differentiated thyroid cancer do not significantly affect outcome...
January 13, 2017: Clinical Oncology: a Journal of the Royal College of Radiologists
https://www.readbyqxmd.com/read/28087101/current-management-of-low-risk-differentiated-thyroid-cancer-and-papillary-microcarcinoma
#2
V D Tarasova, R M Tuttle
Each year, the proportion of thyroid cancer patients presenting with low risk disease is increasing. Moreover, the definition of low risk thyroid cancer is expanding and several histological subtypes beyond papillary microcarcinomas are now classified as low risk disease. This shift in the landscape of thyroid cancer presentation is forcing clinicians to critically re-evaluate whether or not traditional management paradigms that were effective in treating intermediate and high risk disease are applicable to these low risk patients...
January 10, 2017: Clinical Oncology: a Journal of the Royal College of Radiologists
https://www.readbyqxmd.com/read/28063623/immune-checkpoint-inhibitors-in-lung-cancer-an-unheralded-opportunity
#3
R Marshall, A Popple, T Kordbacheh, J Honeychurch, C Faivre-Finn, T Illidge
Lung cancer remains the leading cause of cancer-related death worldwide, with non-small cell lung cancer accounting for 85% of the disease. Over 70% of patients present with locally advanced, non-resectable or metastatic disease and despite improvements in chemoradiotherapy regimens and the development of molecularly targeted agents, 5 year survival rates remain poor, with acquired resistance to novel targeted therapies becoming a growing concern. Currently there remains an unmet need in effectively treating and inducing durable responses in advanced disease...
January 4, 2017: Clinical Oncology: a Journal of the Royal College of Radiologists
https://www.readbyqxmd.com/read/28057404/normal-tissue-complication-probability-ntcp-modelling-of-severe-acute-mucositis-using-a-novel-oral-mucosal-surface-organ-at-risk
#4
J A Dean, L C Welsh, K H Wong, A Aleksic, E Dunne, M R Islam, A Patel, P Patel, I Petkar, I Phillips, J Sham, U Schick, K L Newbold, S A Bhide, K J Harrington, C M Nutting, S L Gulliford
AIMS: A normal tissue complication probability (NTCP) model of severe acute mucositis would be highly useful to guide clinical decision making and inform radiotherapy planning. We aimed to improve upon our previous model by using a novel oral mucosal surface organ at risk (OAR) in place of an oral cavity OAR. MATERIALS AND METHODS: Predictive models of severe acute mucositis were generated using radiotherapy dose to the oral cavity OAR or mucosal surface OAR and clinical data...
January 2, 2017: Clinical Oncology: a Journal of the Royal College of Radiologists
https://www.readbyqxmd.com/read/28057403/the-patterns-of-practice-and-outcomes-of-penile-cancer-in-ontario
#5
A Mahmud, X Qu, D Yip, M Leveridge, W Mackillop
AIMS: Penile cancer is a rare malignancy in Western countries. The management guidelines are mainly derived from retrospective studies as there are no randomised trials. The primary objective of this study was to assess patterns of practice and outcomes of penile squamous cell carcinoma in Ontario. Secondary objectives included examining trends in incidence, pathological characteristics and prognostic factors. MATERIALS AND METHODS: All patients diagnosed with penile cancer between 2000 and 2010 were identified from the Ontario Cancer Registry and all available pathology reports related to penile cancer during this period were reviewed...
January 2, 2017: Clinical Oncology: a Journal of the Royal College of Radiologists
https://www.readbyqxmd.com/read/28049602/are-there-hiv-specific-differences-for-anal-cancer-patients-treated-with-standard-chemoradiotherapy-in-the-era-of-combined-antiretroviral-therapy
#6
D Martin, P Balermpas, E Fokas, C Rödel, M Yildirim
AIMS: Contradicting evidence exists regarding the safety and clinical outcome of standard treatment in HIV-positive patients with anal cancer. We report on our large, single-centre experience in HIV-positive versus HIV-negative patients treated in the era of combined antiretroviral therapy (CART). MATERIALS AND METHODS: Between 1997 and 2015, 142 patients (42 HIV-positive versus 100 HIV-negative) with anal cancer were treated with standard chemoradiotherapy. Patients received a median dose of 50...
December 31, 2016: Clinical Oncology: a Journal of the Royal College of Radiologists
https://www.readbyqxmd.com/read/28043744/thyroid-stimulating-hormone-suppression-in-the-long-term-follow-up-of-differentiated-thyroid-cancer
#7
B Freudenthal, G R Williams
Differentiated thyroid cancer is the most common form of thyroid cancer and its prognosis is favourable in most cases. Suppression of thyroid stimulating hormone (TSH) by supra-physiological thyroid hormone replacement has been the mainstay of long-term management for over 60 years. However, evidence for a beneficial outcome of TSH suppression is conflicting and intervention must be balanced against adverse effects, particularly affecting the cardiovascular system and skeleton. Here we discuss the role of TSH suppression in the long-term management of differentiated thyroid cancer in the context of risk stratification for disease recurrence and the latest clinical guidelines...
December 30, 2016: Clinical Oncology: a Journal of the Royal College of Radiologists
https://www.readbyqxmd.com/read/28043743/internationally-comparable-survival-from-ovarian-cancer-in-patients-treated-in-phase-iii-trial-active-cancer-centres-in-the-uk
#8
EDITORIAL
P Symonds, E Moss, N Reed
No abstract text is available yet for this article.
December 30, 2016: Clinical Oncology: a Journal of the Royal College of Radiologists
https://www.readbyqxmd.com/read/28041764/too-hot-too-cold-or-can-we-get-it-just-right-what-emotional-distance-should-oncologists-keep-from-their-patients
#9
EDITORIAL
D Bloomfield, L Fallowfield, S May, V Jenkins
No abstract text is available yet for this article.
December 29, 2016: Clinical Oncology: a Journal of the Royal College of Radiologists
https://www.readbyqxmd.com/read/28034488/reduced-rates-of-severe-complications-following-a-change-in-anthracycline-taxane-regimen-for-early-breast-cancer-a-single-centre-experience
#10
LETTER
N M L Battisti, T Beaney, S Redana, R Iyer, T Manickavasagar, I Fordham, K Mohammed, A Ring
No abstract text is available yet for this article.
December 26, 2016: Clinical Oncology: a Journal of the Royal College of Radiologists
https://www.readbyqxmd.com/read/28034487/does-the-time-of-radiotherapy-affect-treatment-outcomes-a-review-of-the-literature
#11
S Chan, L Rowbottom, R McDonald, G A Bjarnason, M Tsao, C Danjoux, E Barnes, M Popovic, H Lam, C DeAngelis, E Chow
Circadian rhythm-dependent cell cycle progression produces daily variations in radiosensitivity. This literature review aims to summarise the data on whether radiotherapy outcomes differ depending on administration time. A literature search was conducted on Ovid Medline, Embase, Cochrane Central Register of Controlled Trials and PubMed using key words such as 'radiotherapy', 'circadian rhythm', 'treatment outcome' and 'survival'. Articles evaluating the correlation between radiotherapy time and outcomes in cancer patients were included and relevant information was extracted...
December 26, 2016: Clinical Oncology: a Journal of the Royal College of Radiologists
https://www.readbyqxmd.com/read/27964898/sorafenib-for-the-treatment-of-advanced-hepatocellular-cancer-a-uk-audit
#12
J King, D H Palmer, P Johnson, P Ross, R A Hubner, K Sumpter, S Darby, C Braconi, C Iwuji, D Swinson, P Collins, K Patel, J Nobes, I Muazzam, C Blesing, A Kirkwood, S Nash, T Meyer
AIMS: Sorafenib is the current standard treatment for advanced hepatocellular carcinoma. We carried out a national audit of UK patients treated with sorafenib as standard-of-care and those treated with systemic therapy in first-line trials. MATERIALS AND METHODS: Sorafenib-treated and trial-treated patients were identified via the Cancer Drugs Fund and local databases. Data were collected retrospectively from medical records according to a standard case report form...
December 10, 2016: Clinical Oncology: a Journal of the Royal College of Radiologists
https://www.readbyqxmd.com/read/27939336/adjuvant-chemotherapy-is-indicated-in-patients-with-lower-grade-glioma
#13
EDITORIAL
N Brown, T Carter, P Mulholland
No abstract text is available yet for this article.
December 8, 2016: Clinical Oncology: a Journal of the Royal College of Radiologists
https://www.readbyqxmd.com/read/27956335/who-should-bear-the-cost-of-convenience-a-cost-effectiveness-analysis-comparing-external-beam-and-brachytherapy-radiotherapy-techniques-for-early-stage-breast-cancer
#14
M McGuffin, T Merino, B Keller, J-P Pignol
AIMS: Standard treatment for early breast cancer includes whole breast irradiation (WBI) after breast-conserving surgery. Recently, accelerated partial breast irradiation (APBI) has been proposed for well-selected patients. A cost and cost-effectiveness analysis was carried out comparing WBI with two APBI techniques. MATERIALS AND METHODS: An activity-based costing method was used to determine the treatment cost from a societal perspective of WBI, high dose rate brachytherapy (HDR) and permanent breast seed implants (PBSI)...
December 7, 2016: Clinical Oncology: a Journal of the Royal College of Radiologists
https://www.readbyqxmd.com/read/27894673/treatment-related-death-in-cancer-patients-treated-with-immune-checkpoint-inhibitors-a-systematic-review-and-meta-analysis
#15
O Abdel-Rahman, D Helbling, J Schmidt, U Petrausch, A Giryes, A Mehrabi, O Schöb, M Mannhart, H Oweira
AIMS: We carried out a meta-analysis to determine the risk of treatment-related death associated with immune checkpoint inhibitor use in cancer patients. MATERIALS AND METHODS: We examined data from the Medline and Google Scholar databases. We also examined original studies and review articles for cross-references. Eligible studies included randomised phase II and phase III trials of patients with cancer treated with ipilimumab, pembrolizumab; nivolumab; tremelimumab and atezolizumab...
November 25, 2016: Clinical Oncology: a Journal of the Royal College of Radiologists
https://www.readbyqxmd.com/read/27890346/the-uk-heartspare-study-stage-ii-multicentre-evaluation-of-a-voluntary-breath-hold-technique-in-patients-receiving-breast-radiotherapy
#16
F R Bartlett, E M Donovan, H A McNair, L A Corsini, R M Colgan, P M Evans, L Maynard, C Griffin, J S Haviland, J R Yarnold, A M Kirby
AIMS: To evaluate the feasibility and heart-sparing ability of the voluntary breath-hold (VBH) technique in a multicentre setting. MATERIALS AND METHODS: Patients were recruited from 10 UK centres. Following surgery for early left breast cancer, patients with any heart inside the 50% isodose from a standard free-breathing tangential field treatment plan underwent a second planning computed tomography (CT) scan using the VBH technique. A separate treatment plan was prepared on the VBH CT scan and used for treatment...
November 24, 2016: Clinical Oncology: a Journal of the Royal College of Radiologists
https://www.readbyqxmd.com/read/27839942/training-in-clinical-oncology-and-the-transition-from-trainee-to-consultant-results-of-the-royal-college-of-radiologists-2015-post-certificate-of-completion-of-training-survey
#17
J Dickson, D Liu, D Bloomfield
AIMS: To seek feedback from clinical oncologists as to their experiences of specialty training and, where applicable, the transition to working as a consultant in the National Health Service. MATERIALS AND METHODS: All clinical oncologists gaining a Certificate of Completion of Training between 1 July 2012 and 30 June 2014 were identified through records held by the Royal College of Radiologists and approached in May 2015 to take part in an online survey. RESULTS: The survey was completed by 38 of 80 clinical oncologists invited to take part (48% response rate)...
November 10, 2016: Clinical Oncology: a Journal of the Royal College of Radiologists
https://www.readbyqxmd.com/read/27838135/the-impact-of-systemic-therapy-beyond-first-line-treatment-for-advanced-cervical-cancer
#18
J McLachlan, S Boussios, A Okines, D Glaessgen, S Bodlar, R Kalaitzaki, A Taylor, S Lalondrelle, M Gore, S Kaye, S Banerjee
AIMS: Despite recent advances in the primary and secondary prevention of cervical cancer, a significant number of women present with or develop metastatic disease. There is currently no consensus on the standard of care for second-line systemic treatment of recurrent/metastatic cervical cancer. The purpose of this study was to evaluate the second-line systemic therapy used and the associated outcomes in a single cancer centre. MATERIALS AND METHODS: A retrospective review of patients with cervical cancer who received one or more lines of treatment for recurrent or metastatic cervical cancer at the Royal Marsden Hospital between 2004 and 2014 was carried out...
November 9, 2016: Clinical Oncology: a Journal of the Royal College of Radiologists
https://www.readbyqxmd.com/read/27829531/patterns-of-referral-to-radiation-oncology-among-patients-with-bladder-cancer-a-population-based-study
#19
J S Quirt, D R Siemens, K Zaza, W J Mackillop, C M Booth
AIMS: Radical radiotherapy is a reasonable alternative to cystectomy for some patients with invasive bladder cancer, and postoperative radiotherapy may be indicated in patients at high risk of local recurrence. Here we describe pre- and postoperative radiation oncology consultation among patients with bladder cancer in Ontario. MATERIALS AND METHODS: Records of radiotherapy and surgery were linked to the Ontario Cancer Registry (OCR) to identify all patients who received treatment with curative intent for bladder cancer between 1994 and 2008...
November 6, 2016: Clinical Oncology: a Journal of the Royal College of Radiologists
https://www.readbyqxmd.com/read/27810119/initial-results-from-the-royal-college-of-radiologists-uk-national-audit-of-anal-cancer-radiotherapy-2015
#20
R Muirhead, K Drinkwater, S M O'Cathail, R Adams, R Glynne-Jones, M Harrison, M A Hawkins, D Sebag-Montefiore, D C Gilbert
AIMS: UK guidance was recently developed for the treatment of anal cancer using intensity-modulated radiotherapy (IMRT). We audited the current use of radiotherapy in UK cancer centres for the treatment of anal cancer against such guidance. We describe the acute toxicity of IMRT in comparison with patient population in the audit treated with two-phase conformal radiotherapy and the previous published data from two-phase conformal radiotherapy, in the UK ACT2 trial. MATERIALS AND METHODS: A Royal College of Radiologists' prospective national audit of patients treated with radiotherapy in UK cancer centres was carried out over a 6 month period between February and July 2015...
October 31, 2016: Clinical Oncology: a Journal of the Royal College of Radiologists
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