journal
MENU ▼
Read by QxMD icon Read
search

Journal of Liposome Research

journal
https://www.readbyqxmd.com/read/28689479/introduction-to-the-25th-anniversary-ambisome%C3%A2-festschrift
#1
G M Jensen, K J Jalkanen
No abstract text is available yet for this article.
July 10, 2017: Journal of Liposome Research
https://www.readbyqxmd.com/read/28670949/preparation-and-optimization-of-rivastigmine-loaded-tocopherol-succinate-based-solid-lipid-nanoparticles
#2
Fariba Malekpour-Galogahi, Ashrafalasadat Hatamian-Zarmi, Fariba Ganji, Bahman Ebrahimi-Hosseinzadeh, Fahimeh Nojoki, Razi Sahraeian, Zahra Beagom Mokhtari-Hosseini
Rivastigmine hydrogen tartrate (RHT) is a pseudo-irreversible inhibitor of cholinesterase, and is used for the treatment of Alzheimer's. However, RHT delivery to the brain is limited by the Blood-Brain Barrier (BBB). The purpose of this study was to improve the brain-targeting delivery of RHT by producing and optimizing rivastigmine hydrogen tartrate-loaded tocopherol succinate-based solid lipid nanoparticles (RHT-SLNs). RHT-SLNs were prepared using the microemulsion technique. The impact of significant variables such as surfactant concentration and drug/lipid ratio on the size of RHT-SLNs and their drug loading and encapsulation efficiency was analyzed using a five-level central composite design (CCD)...
July 2, 2017: Journal of Liposome Research
https://www.readbyqxmd.com/read/28641466/a-model-of-lipid-rearrangements-during-pore-formation-in-the-dppc-lipid-bilayer
#3
Artur Wrona, Krystian Kubica
CONTEXT: The molecular bases of pore formation in the lipid bilayer remain unclear, as do the exact characteristics of their sizes and distributions. To understand this process, numerous studies have been performed on model lipid membranes including cell-sized giant unilamellar vesicles (GUV). The effect of an electric field on DPPC GUV depends on the lipid membrane state: in the liquid crystalline phase the created pores have a cylinder-like shape, whereas in the gel phase a crack has been observed...
June 23, 2017: Journal of Liposome Research
https://www.readbyqxmd.com/read/28627268/the-significance-of-drug-to-lipid-ratio-to-the-development-of-optimized-liposomal-formulation
#4
Maria Chountoulesi, Nikolaos Naziris, Natassa Pippa, Costas Demetzos
Liposomes are considered to be one of the most extensively investigated drug delivery nanosystems. Each drug can be loaded either in the liposomal hydrophilic core or within the lipidic bilayer and delivered eventually to the proper site into the organism. There are already many marketed approved liposomal products. The development of a liposomal product is a quite complicated process, while many critical parameters have to be investigated during the preparation process. The present study deals with the drug-to-lipid ratio (D/L ratio), which is a critical process parameter, expresses the actual capacity of the liposome to accommodate the drug and can play a key role at the optimization of every liposomal formulation...
June 18, 2017: Journal of Liposome Research
https://www.readbyqxmd.com/read/28618876/niosomes-for-oral-delivery-of-nateglinide-in-situ-in-vivo-correlation
#5
Amal A Sultan, Sanaa A El-Gizawy, Mohamed A Osman, Gamal M El Maghraby
Niosomes have been claimed to enhance intestinal absorption and to widen the absorption window of acidic drugs. This was reported after monitoring the intestinal absorption in situ. Accordingly, the aim of this work was to investigate the effect of niosomal encapsulation on intestinal absorption and oral bioavailability of nateglinide. This was conducted with the goal of correlation between in situ intestinal absorption and in vivo availability. The drug was encapsulated into proniosomes. The niosomes resulting after hydration of proniosomes were characterized with respect to vesicle size and drug entrapment efficiency...
June 15, 2017: Journal of Liposome Research
https://www.readbyqxmd.com/read/28539072/design-and-characterization-of-multifaceted-lyophilized-liposomal-wafers-with-promising-wound-healing-potential
#6
Amelia M Avachat, Pooja J Takudage
Various dressings are available to heal chronic wounds which many times fail to achieve the expected results. To overcome some of their drawbacks, formulation of a novel dressing; lyophilized liposomal wafers having better wound healing potential has been proposed in the present study. The drug incorporated in the formulation is gatifloxacin (GTX) which is a fourth-generation fluoroquinolone antibiotic having in vitro activity against both Gram-negative and Gram-positive bacteria. The formulation was designed in three stages where at first liposomes were prepared, the liposomes were converted to gel using chitosan and lastly this gel was lyophilized to form liposomal wafers...
June 15, 2017: Journal of Liposome Research
https://www.readbyqxmd.com/read/28480760/tissue-pharmacokinetics-and-pharmacodynamics-of-ambisome%C3%A2-l-ambis-in-uninfected-and-infected-animals-and-their-effects-on-dosing-regimens
#7
J P Adler-Moore, R T Proffitt, J A Olson, G M Jensen
By selecting a unique combination of lipids and amphotericin B, the liposome composition for AmBisome® (L-AmBis) has been optimized resulting in a formulation that is minimally toxic, targets to fungal cell walls, and distributes into and remains for days to weeks in various host tissues at drug levels above the MIC for many fungi. Procedures have been standardized to ensure that large scale production of the drug retains the drug's low toxicity profile, favorable pharmacokinetics and antifungal efficacy. Tissue accumulation and clearance with single or multiple intravenous administration is similar in uninfected and infected animal species, with tissue accumulation being dose-dependent and the liver and spleen retaining the most drug...
May 31, 2017: Journal of Liposome Research
https://www.readbyqxmd.com/read/28480807/tri-block-co-polymer-nanocarriers-for-enhancement-of-oral-delivery-of-felodipine-preparation-in-vitro-characterization-and-ex-vivo-permeation
#8
Sinar Sayed, Basant A Habib, Ghada M Elsayed
This study aimed to prepare, optimize and characterize novel felodipine-loaded polymeric nanomicelles, using a pluronic mixture of F127 and P123. Thin-film hydration method was adopted for the preparation of different polymeric nanomicelles (T1-T12) according to a 4(1).3(1) full factorial design. Factors studied were: Pluronic®:drug ratio (P:D ratio) (10, 20, 30 and 40 w/w) and percent of hydrophilic polymer (F127%) (33.33%, 50% and 66.67% w/w). Optimization criteria were to maximize transmittance percent (T%) and entrapment efficiency percent (EE%) and to minimize particle size (PS) and polydispersity index (PDI)...
May 25, 2017: Journal of Liposome Research
https://www.readbyqxmd.com/read/28480778/ptd-modified-paclitaxel-anti-resistant-liposomes-for-treatment-of-drug-resistant-non-small-cell-lung-cancer
#9
Rui-Jun Ju, Lan Cheng, Yao Xiao, Xin Wang, Cui-Qing Li, Xiao-Ming Peng, Xue-Tao Li
CONTEXT: Non-small cell lung carcinoma (NSCLC) is a type of epithelial lung cancer that accounts for approximately 80-85% of lung carcinoma cases. Chemotherapy for the NSCLC is unsatisfactory due to multidrug resistance, nonselectively distributions and the accompanying side effects. OBJECTIVE: The objective of this study was to develop a kind of PTD modified paclitaxel anti-resistant liposomes to overcome these chemotherapy limitations. METHOD: The studies were performed on LLT cells and resistant LLT cells in vitro and on NSCLC xenograft mice in vivo, respectively...
May 24, 2017: Journal of Liposome Research
https://www.readbyqxmd.com/read/28067107/physical-properties-and-biological-interactions-of-liposomes-developed-as-a-drug-carrier-in-the-field-of-regenerative-medicine
#10
Sławomir Lewicki, Monika Leśniak, Eugeniusz Krzysztof Machaj, Małgorzata Antos-Bielska, Elżbieta Anna Trafny, Janusz Kocik, Zygmunt Pojda
Liposomes are used for encapsulation of the active compounds in different therapies, with the increasing frequency. The important areas of clinical applications of liposomes are cancer targeted treatment, antibiotic delivery or regenerative medicine. The liposomes can transfer both hydrophilic and hydrophobic compounds and have the lipid bilayer which imitates the cell membrane. Liposomes additionally may extend half-live period of drugs and protect them against the elimination in different ways, such as phagocytosis, enzymatic cleavage or exclusion by detoxification...
June 2017: Journal of Liposome Research
https://www.readbyqxmd.com/read/28067087/oral-delivery-of-allopurinol-niosomes-in-treatment-of-gout-in-animal-model
#11
Neelu Singh, Poonam Parashar, Chandra Bhushan Tripathi, Jovita Kanoujia, Gaurav Kaithwas, Shubhini A Saraf
CONTEXT: Gout is a painful disorder which does not have an efficient delivery system for its treatment. OBJECTIVE: Development and in vitro, in vivo evaluation of allopurinol-loaded nonionic surfactant-based niosomes was envisaged. MATERIALS AND METHODS: Niosomes were prepared with Span 20 and Tween 20 (1:1 molar ratio) using ether injection method. The formulations were screened for entrapment efficiency, particle size analysis, zeta potential, release kinetics, in vivo activity, and stability studies...
June 2017: Journal of Liposome Research
https://www.readbyqxmd.com/read/27558454/design-and-development-of-ph-responsive-hspc-c12h25-paa-chimeric-liposomes
#12
Nikolaos Naziris, Natassa Pippa, Anastasia Meristoudi, Stergios Pispas, Costas Demetzos
The application of stimuli-responsive medical practices has emerged, in which pH-sensitive liposomes figure prominently. This study investigates the impact of the incorporation of different amounts of pH-sensitive polymer, C12H25-PAA (poly(acrylic acid) with a hydrophobic end group) in l-α-phosphatidylcholine, hydrogenated (Soy) (HSPC) phospholipidic bilayers, with respect to biomimicry and functionality. PAA is a poly(carboxylic acid) molecule, classified as a pH-sensitive polymer, whose pH-sensitivity is attributed to its regulative -COOH groups, which are protonated under acidic pH (pKa ∼4...
June 2017: Journal of Liposome Research
https://www.readbyqxmd.com/read/27250110/sensitization-of-multidrug-resistant-malignant-cells-by-liposomes-co-encapsulating-doxorubicin-and-chloroquine-through-autophagic-inhibition
#13
Menghua Gao, Yuzhen Xu, Liyan Qiu
Adenosine triphosphate (ATP)-binding cassette (ABC) transporters play a key role in the development of multidrug resistance (MDR) in cancer cells. P-glycoprotein (P-gp) and multidrug resistance-associated protein 1 (MRP1) are important proteins in this superfamily which are widely expressed on the membranes of multidrug resistance (MDR) cancer cells. Besides, upregulation of cellular autophagic responses is considered a contributing factor for MDR in cancer cells. We designed a liposome system co-encapsulating a chemotherapeutic drug (doxorubicin hydrochloride, DOX) and a typical autophagy inhibitior (chloroquine phosphate, CQ) at a weight ratio of 1:2 and investigated its drug resistance reversal mechanism...
June 2017: Journal of Liposome Research
https://www.readbyqxmd.com/read/27184460/pegylated-niosomes-mediated-drug-delivery-systems-for-paeonol-preparation-pharmacokinetics-studies-and-synergistic-anti-tumor-effects-with-5-fu
#14
Rui-Xi He, Xi Ye, Rui Li, Wei Chen, Tao Ge, Tian-Qing Huang, Xiang-Jiang Nie, He-Jun-Tao Chen, Dai-Yin Peng, Wei-Dong Chen
This work describes the preparation of a PEGylated niosomes-mediated drug delivery systems for Paeonol, thereby improving the bioavailability and chemical stability of Paeonol, prolonging its cellular uptake and enhancing its synergistic anti-cancer effects with 5-Fu. PEGylated niosomes, which are prepared from biocompatible nonionic surfactant of Spans 60 and cholesterol, and modified with PEG-SA. Pae-PEG-NISVs were evaluated in vitro and in vivo. The cytotoxicity of Pae-PEG-NISVs was investigated against HepG2 cells...
June 2017: Journal of Liposome Research
https://www.readbyqxmd.com/read/27079800/design-and-evaluation-of-proniosomes-as-a-carrier-for-ocular-delivery-of-lomefloxacin-hcl
#15
Rawia M Khalil, Ghada A Abdelbary, Mona Basha, Ghada E A Awad, Hadeer A El-Hashemy
The current investigation aims to develop and evaluate novel ocular proniosomal gels of lomefloxacin HCl (LXN); in order to improve its ocular bioavailability for the management of bacterial conjunctivitis. Proniosomes were prepared using different types of nonionic surfactants solely and as mixtures with Span 60. The formed gels were characterized for entrapment efficiency, vesicle size, and in vitro drug release. Only Span 60 was able to form stable LXN-proniosomal gel when used individually while the other surfactants formed gels only in combination with Span 60 at different ratios...
June 2017: Journal of Liposome Research
https://www.readbyqxmd.com/read/27050330/structures-similar-to-lipid-emulsions-and-liposomes-dipalmitoylphosphatidylcholine-cholesterol-tween-20-span-20-or-tween-80-span-80-in-aqueous-media
#16
Carlos Juárez-Osornio, Jesús Gracia-Fadrique
In the present work, we show that we obtained nanometric structures made of water, 1,2-dipalmitoyl-sn-glycero-3-phosphatidylcholine (DPPC), cholesterol (Chol), and a mixture of ethoxylated and non-ethoxylated sorbitan fatty acid esters (Tween 20, Span 20, Tween 80, and Span 80) by mixing all of them near the cloud point temperature (cp) of the ethoxylated surfactant. The influence that the constituents had on the size of the particle was determined by a pseudo-ternary phase diagram of water/Tween-Span/DPPC-Chol; the colloidal particles obtained were studied by differential scanning calorimetry, confocal fluorescence microscopy, scanning electron microscopy, and atomic force microscopy...
June 2017: Journal of Liposome Research
https://www.readbyqxmd.com/read/26982164/tumor-delivery-of-liposomal-doxorubicin-prepared-with-poly-l-glutamic-acid-as-a-drug-trapping-agent
#17
Andang Miatmoko, Kumi Kawano, Hitomi Yoda, Etsuo Yonemochi, Yoshiyuki Hattori
CONTEXT: Poly-l-glutamic acid (PGA) is an anionic polymer with a large number of carboxyl groups that can interact electrostatically with cationic drugs such as doxorubicin (DOX). OBJECTIVE: For stable encapsulation of DOX into liposomes, we prepared triethylamine (TEA)-PGA-liposomes using PGA as an internal trapping agent. METHODS: We prepared TEA-PGA-liposomes by remote loading of DOX with a TEA gradient into preformed liposomes prepared with 1, 2, or 4 mg/mL PGA (molecular weights 4800, 9800, and 20 500), and evaluated their biodistribution and antitumor effects on Lewis lung carcinoma (LLC) tumor-bearing mice...
June 2017: Journal of Liposome Research
https://www.readbyqxmd.com/read/26981843/introduction-of-cationic-virosome-derived-from-vesicular-stomatitis-virus-as-a-novel-gene-delivery-system-for-sf9-cells
#18
Yahya Mohammadzadeh, Shima Gholami, Narges Rasouli, Sahar Sarrafzadeh, Nasim Sadat Seyed Tabib, Mohammad Hasan Samiee Aref, Asghar Abdoli, Peyvand Biglari, Fatemeh Fotouhi, Behrokh Farahmand, Masoumeh Tavassoti Kheiri, Abbas Jamali
Insect-derived cell lines are used extensively to produce recombinant proteins because they are capable of performing a range of post-translational modifications. Due to their significance in biotechnological applications, various methods have been developed to transfect them. In this study, we introduce a virosome constructed from vesicular stomatitis virus (VSV) as a new delivery system for sf9 cells. We labeled these VSV virosomes by fluorescent probe Rhodamine B chloride (R18). By fluorescence microscope observation and conducting a fusion assay, we confirmed the uptake of VSV virosomes via endocytosis by sf9 cells and their fusion with the endosomal membrane...
June 2017: Journal of Liposome Research
https://www.readbyqxmd.com/read/28337938/optimization-and-development-of-antidiabetic-phytosomes-by-the-box-behnken-design
#19
Sushila Rathee, Anjoo Kamboj
Researchers have extensively reviewed on herbs and natural products for their marked clinical efficacy in some recent years, however, maximum of the newly discovered bioactive constituents offer poor bioavailability due to their large size molecules or to their poor miscibility with oils and lipids, thereby limiting their ability to pass across the lipid-rich outer membranes of the enterocytes of the small intestine. Phytosomes are more bioavailable as compared to herbal extracts owing to their enhanced capacity to cross the bio-membranes and thus reaching the systemic circulation...
April 17, 2017: Journal of Liposome Research
https://www.readbyqxmd.com/read/28287014/preparation-and-optimization-of-tablets-containing-a-self-nano-emulsifying-drug-delivery-system-loaded-with-rosuvastatin
#20
Heba F Salem, Rasha M Kharshoum, Abdel Khalek A Halawa, Demiana M Naguib
BACKGROUND: Rosuvastatin (ROS) calcium is the latest synthetic drug in the statin group that has an anti-hyperlipidemic activity. It is available as tablets, and its poor aqueous solubility, slow dissolution rate and low-absorption extent result in less than 20% bioavailability and about 80% being excreted unchanged in the feces without absorption. OBJECTIVE: To utilize nanotechnology to reformulate ROS as a self-nano-emulsifying drug delivery system (SNEDDS), and utilizing design optimization to fabricate the SNEDDS as a tablet...
March 13, 2017: Journal of Liposome Research
journal
journal
30359
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"