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Journal of Liposome Research

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https://www.readbyqxmd.com/read/28095734/entrapment-efficiency-of-pyridoxine-hydrochloride-in-unilamellar-liposomes-experimental-versus-model-generated-data
#1
Heba Abd-El-Azim, Alyaa Ramadan, Noha Nafee, Nawal Khalafallah
The present study investigates the effect of the preparation method (four methods) and formulation additives (propylene glycol (PG) and cholesterol (CH)) on the entrapment efficiency (EE) of pyridoxine hydrochloride (vitamin B6 (VB6)), representing hydrophilic water-soluble low permeable vitamins, in unilamellar liposomes. The main aim is to compare determined EE with predicted values generated using a web-published, computational model. Results showed that among the different preparation methods, modified film hydration showed significantly higher EE (p < 0...
January 18, 2017: Journal of Liposome Research
https://www.readbyqxmd.com/read/28006995/new-lipid-formulation-of-octenidine-dihydrochloride
#2
Kamila Szostak, Aleksander Czogalla, Magdalena Przybyło, Marek Langner
Octenidine dihydrochloride is an effective antiseptic compound which mode of action is based on destabilization plasma membrane of microorganisms. This ensures that microorganisms cannot develop the drug resistance in a straightforward way, as the entire cellular structure, rather than specific molecular target is affected. Since the octenidine is a hydrophobic compound, it requires organic solvent such as phenoxyethanol in order to be effectively administered. However, the presence of phenoxyethanol has strong irritating effect, particularly when applied on open wounds and mucous membranes...
January 18, 2017: Journal of Liposome Research
https://www.readbyqxmd.com/read/28081647/interaction-of-s-layer-proteins-of-lactobacillus-kefir-with-model-membranes-and-cells
#3
Axel Hollmann, Lucrecia Delfederico, Nuno Correia Santos, E Anibal Disalvo, Liliana Semorile
In previous works, it was shown that S-layer proteins from Lactobacillus kefir were able to recrystallize and stabilize liposomes, this feature reveling a great potential for developing liposomal-based carriers. Despite previous studies on this subject are important milestones, a number of questions remain unanswered; In this context, the feasibility of S-layer proteins as a biomaterial for drug delivery was evaluated in this work. First, S-layer proteins were fully characterized by Electron microscopy, 2D-electrophoresis, and HPAEC-PAD...
January 12, 2017: Journal of Liposome Research
https://www.readbyqxmd.com/read/28081643/microemulsion-for-topical-delivery-of-fenoprofen-calcium-in-vitro-and-in-vivo-evaluation
#4
Dalia Ali Farghaly, Ahmed A Aboelwafa, Manal Y Hamza, Magdy I Mohamed
The aim of this study was to investigate microemulsion based topical delivery system for fenoprofen calcium to eliminate its oral gastrointestinal adverse effects. Microemulsion was prepared by the water titration method using oleic acid as oil phase, tween 80 as a surfactant and propylene glycol as a cosurfactant. Oleic acid was selected as oil phase due to its good solubilizing capacity. Microemulsion existence region was determined using pseudo-ternary phase diagrams for preparing different formulations...
January 12, 2017: Journal of Liposome Research
https://www.readbyqxmd.com/read/28067107/physical-properties-and-biological-interactions-of-liposomes-developed-as-a-drug-carrier-in-the-field-of-regenerative-medicine
#5
Sławomir Lewicki, Monika Leśniak, Eugeniusz Krzysztof Machaj, Małgorzata Antos-Bielska, Elżbieta Anna Trafny, Janusz Kocik, Zygmunt Pojda
Liposomes are used for encapsulation of the active compounds in different therapies, with the increasing frequency. The important areas of clinical applications of liposomes are cancer targeted treatment, antibiotic delivery or regenerative medicine. The liposomes can transfer both hydrophilic and hydrophobic compounds and have the lipid bilayer which imitates the cell membrane. Liposomes additionally may extend half-live period of drugs and protect them against the elimination in different ways, such as phagocytosis, enzymatic cleavage or exclusion by detoxification...
January 8, 2017: Journal of Liposome Research
https://www.readbyqxmd.com/read/28067087/oral-delivery-of-allopurinol-niosomes-in-treatment-of-gout-in-animal-model
#6
Neelu Singh, Poonam Parashar, Chandra Bhushan Tripathi, Jovita Kanoujia, Gaurav Kaithwas, Shubhini A Saraf
CONTEXT: Gout is a painful disorder which does not have an efficient delivery system for its treatment. OBJECTIVE: Development and in vitro, in vivo evaluation of allopurinol loaded nonionic surfactant based niosomes was envisaged. MATERIALS AND METHODS: Niosomes were prepared with Span 20 and Tween 20(1:1 molar ratio) using ether injection method. The formulations were screened for entrapment efficiency, particle size analysis, zeta potential, release kinetics, in vivo activity and stability studies...
January 8, 2017: Journal of Liposome Research
https://www.readbyqxmd.com/read/27892752/concentration-dependence-of-nitroxyl-spin-probes-in-liposomal-solution-electron-spin-resonance-and-overhauser-enhanced-magnetic-resonance-studies
#7
V Meenakumari, Hideo Utsumi, A Jawahar, A Milton Franklin Benial
In this work, the detailed studies of electron spin resonance (ESR) and overhauser-enhanced magnetic resonance imaging (OMRI) were carried out for permeable nitroxyl spin probe, MC-PROXYL as a function of agent concentration in liposomal solution. In order to compare the impermeable nature of nitroxyl radical, the study was also carried out only at 2 mM concentration of carboxy-PROXYL. The ESR parameters were estimated using L-band and 300 MHz ESR spectrometers. The line width broadening was measured as a function of agent concentration in liposomal solution...
December 21, 2016: Journal of Liposome Research
https://www.readbyqxmd.com/read/27834116/ethanol-based-proliposome-delivery-systems-of-paclitaxel-for-in-vitro-application-against-brain-cancer-cells
#8
Mohammad Najlah, Mohit Jain, Ka-Wai Wan, Waqar Ahmed, Mohamed Albed Alhnan, David A Phoenix, Kevin M G Taylor, Abdelbary Elhissi
In this study the anticancer activity of paclitaxel-loaded nano-liposomes on glioma cell lines was investigated. Soya phosphatidylcholine:cholesterol (SPC:Chol), hydrogenated soya phosphatidylcholine:cholesterol (HSPC:Chol) or dipalmitoylphosphatidylcholine:cholesterol (DPPC:Chol) in 1:1 mole ratio were used to prepare ethanol-based proliposomes. Following hydration of proliposomes, the size of resulting vesicles was subsequently reduced to nanometer scale via probe-sonication. The resulting formulations were characterized in terms of size, zeta potential and morphology of the vesicles, and entrapment efficiency of paclitaxel (PX) as well as the final pH of the preparations...
December 14, 2016: Journal of Liposome Research
https://www.readbyqxmd.com/read/27788618/optimization-of-prednisolone-loaded-long-circulating-liposomes-via-application-of-quality-by-design-qbd-approach
#9
Bianca Sylvester, Alina Porfire, Dana-Maria Muntean, Laurian Vlase, Lavinia Lupuţ, Emilia Licarete, Alina Sesarman, Marius Costel Alupei, Manuela Banciu, Marcela Achim, Ioan Tomuţă
Quality by design principles (QbD) were used to assist the formulation of prednisolone-loaded long-circulating liposomes (LCL-PLP) in order to gain a more comprehensive understanding of the preparation process. This approach enables us to improve the final product quality in terms of liposomal drug concentration, encapsulation efficiency and size, and to minimize preparation variability. A 19-run D-optimal experimental design was used to study the impact of the highest risk factors on PLP liposomal concentration (Y1- μg/ml), encapsulation efficiency (Y2-%) and size (Y3-nm)...
November 16, 2016: Journal of Liposome Research
https://www.readbyqxmd.com/read/27788607/investigating-the-penetrating-potential-of-nanocomposite-%C3%AE-cycloethosomes-development-using-central-composite-design-in-vitro-and-ex-vivo-characterization
#10
Nida Akhtar, Anurag Verma, Kamla Pathak
CONTEXT: Atopic dermatitis (AD) is a chronic skin disease characterized by inflammation of the skin and has exhibited remarkable repercussions on human life across the globe. Fluocinolone acetonide (FA), a topical corticosteroid is employed in the treatment of atopic dermatitis, but suffers from limited penetration into deeper epidermis of atopic skin. OBJECTIVE: The present investigation was focused to explore the utility of β-cylcoethosomes in improvising the penetration deep into the skin...
November 16, 2016: Journal of Liposome Research
https://www.readbyqxmd.com/read/27809639/polymer-coated-liposomes-for-use-in-the-oral-cavity-a-study-of-the-in-vitro-toxicity-effect-on-cell-permeability-and-interaction-with-mucin
#11
Therese Klemetsrud, Anna-Lena Kjøniksen, Marianne Hiorth, Jette Jacobsen, Gro Smistad
In this study we investigated the in vitro toxicity, impact on cell permeability and mucoadhesive potential of polymer coated liposomes intended for use in the oral cavity. A TR146 cell line was used as a model. The overall aim was to end up with a selection of safe polymer coated liposomes with promising mucoadhesive properties for drug delivery to the oral cavity. The following polymers were tested: chitosan, low-methoxylated pectin (LM-pectin), high-methoxylated pectin (HM-pectin), amidated pectin (AM-pectin), Eudragit, poly(N-isopropylacrylamide-co-methacrylic acid) (p(NIPAAM-co-MAA)), hydrophobically modified hydroxyethyl cellulose (HM-HEC), and hydrophobically modified ethyl hydroxyethyl cellulose (HM-EHEC)...
November 3, 2016: Journal of Liposome Research
https://www.readbyqxmd.com/read/26982006/a-niosomal-bilayer-of-sorbitan-monostearate-in-complex-with-flavones-a-molecular-dynamics-simulation-study
#12
Yoochan Myung, Seongyeol Yeom, Sanghwa Han
Bilayers prepared from sorbitan fatty acid esters (Span) have been frequently used for delivery of drugs including flavonoids. We applied molecular dynamics simulation to characterize the structure of a sorbitan monostearate (Span 60) bilayer in complex with three representative flavones, a subclass of flavonoids. At a low concentration, unsubstituted flavone, the most hydrophobic member, was able to flip over and cross the bilayer with a large diffusion coefficient. At a high concentration, it was accumulated at the bilayer center resulting in a phase separation...
December 2016: Journal of Liposome Research
https://www.readbyqxmd.com/read/26872552/edge-activators-and-a-polycationic-polymer-enhance-the-formulation-of-porous-voriconazole-nanoagglomerate-for-the-use-as-a-dry-powder-inhaler
#13
Heba F Salem, Rasha M Kharshoum, Lekaa F Abdel Hakim, Mohamed E Abdelrahim
PURPOSE: Voriconazole has both low aqueous solubility and stability. We hypothesize that designing voriconazole in the form of a nano powder inhaler at a geometric diameter within 1-5 μm will enhance its stability and solubility. Therefore, we prepared nanoagglomerates of voriconazole which will collapse in the lungs to reform the nanoparticles. METHOD: The nanoparticles were formulated using both stearic acid and sodium deoxycholate as edge activators. Osmogenic polycation polyethyleneimine (PEI) was used to form agglomerates of controllable size...
December 2016: Journal of Liposome Research
https://www.readbyqxmd.com/read/26850783/effect-of-cisplatin-containing-liposomes-formulated-by-unsaturated-chain-containing-lipids-on-gynecological-tumor-cells
#14
Paola Ringhieri, Alessandra Pannunzio, Angelina Boccarelli, Giancarlo Morelli, Mauro Coluccia, Diego Tesauro
Gynecological tumors are major therapeutic areas of platinum-based anticancer drugs. Here, we report the characterization and in vitro biological assays of cisplatin-containing Egg L-α-phosphatidylcholine liposomes with different amounts of cholesterol. Dynamic light scattering estimated sizes of all obtained liposomes in the 100 nm range that are suitable for in vivo use. On the basis of these data and of the drug loading values, the best formulation has been selected. Stability and drug release properties of platinum-containing liposomes have been verified in serum...
December 2016: Journal of Liposome Research
https://www.readbyqxmd.com/read/26785055/preparation-optimization-and-evaluation-of-zaltoprofen-loaded-microemulsion-and-microemulsion-based-gel-for-transdermal-delivery
#15
Ratnesh Mishra, Kedar S Prabhavalkar, Lokesh Kumar Bhatt
CONTEXT: Zaltoprofen, a non-steroidal anti-inflammatory drug, has potent inhibitory action against nociceptive responses. However, gastrointestinal ulcer accompanied with anemia due to the bleeding are most cited side effects associated with it. Due to this, administration of Zaltoprofen is not suitable for individuals with gastric ulcer. Thus, there is unmet need to develop an alternative delivery system that will be easy to administer and can avoid ulcerogenic side effects associated with it...
December 2016: Journal of Liposome Research
https://www.readbyqxmd.com/read/26784833/solid-lipid-nanoparticles-for-transdermal-delivery-of-avanafil-optimization-formulation-in-vitro-and-ex-vivo-studies
#16
Mallesh Kurakula, Osama A A Ahmed, Usama A Fahmy, Tarek A Ahmed
CONTEXT: Avanafil (AVA) is used in the treatment of erectile dysfunction, but is reported for its poor aqueous solubility. Solid lipid nanoparticles (SLNs) are lipid carriers that can greatly enhance drug solubility and bioavailability. OBJECTIVE: This work was aimed to formulate and optimize AVA SLNs with subsequent loading into hydrogel films for AVA transdermal delivery. MATERIALS AND METHODS: AVA SLNs were prepared utilizing homogenization followed by ultra-sonication technique...
December 2016: Journal of Liposome Research
https://www.readbyqxmd.com/read/26784587/hyaluronic-acid-modified-ph-sensitive-liposomes-for-targeted-intracellular-delivery-of-doxorubicin
#17
Shivani Rai Paliwal, Rishi Paliwal, Govind Prasad Agrawal, Suresh Prasad Vyas
CONTEXT: Surface-modified pH-sensitive liposomal system may be useful for intracellular delivery of chemotherapeutics. OBJECTIVE: Achieving site-specific targeting with over-expressed hyaluronic acid (HA) receptors along with using pH sensitive liposome carrier for intracellular drug delivery was the aim of this study. MATERIALS AND METHODS: Stealth HA-targeted pH-sensitive liposomes (SL-pH-HA) were developed and evaluated to achieve effective intracellular delivery of doxorubicin (DOX) vis-a-vis enhanced antitumor activity...
December 2016: Journal of Liposome Research
https://www.readbyqxmd.com/read/26758957/poloxamer-407-based-intranasal-thermoreversible-gel-of-zolmitriptan-loaded-nanoethosomes-formulation-optimization-evaluation-and-permeation-studies
#18
Santosh Shelke, Sadhana Shahi, Sunil Jalalpure, Dinesh Dhamecha
Zolmitriptan is the drug of choice for migraine, but low oral bioavailability (<50%) and recurrence of migraine lead to frequent dosing and increase in associated side effects. Increase in the residence time of drug at the site of drug absorption along with direct nose to brain targeting of zolmitriptan can be a solution to the existing problems. Hence, in the present investigation, thermoreversible intranasal gel of zolmitriptan-loaded nanoethosomes was formulated by using mucoadhesive polymers to increase the residence of the drug into the nasal cavity...
December 2016: Journal of Liposome Research
https://www.readbyqxmd.com/read/26634871/a-biologically-active-delivery-material-with-dried-rehydrated-vesicles-containing-the-anti-inflammatory-diclofenac-for-potential-wound-healing
#19
Helena Ferreira, Raquel Silva, Teresa Matamá, Carla Silva, Andreia C Gomes, Artur Cavaco-Paulo
Chronic wounds usually remain in the inflammatory phase of the healing process during several months or even years. Hence, a continuous research has been resulting in the development of wound dressings with improved performance. Herein, we report a delivery system for cutaneous wound healing, consisting of a textile material (non-woven gauzes) covered with lipidic vesicles containing diclofenac, a non-steroidal anti-inflammatory drug (NSAID). This study also aims to compare the entrapment efficiency data with previous works and confirm that this parameter and drug amount are not directly correlated...
December 2016: Journal of Liposome Research
https://www.readbyqxmd.com/read/26585564/stability-of-niosomes-with-encapsulated-vitamin-d3-and-ferrous-sulfate-generated-using-a-novel-supercritical-carbon-dioxide-method
#20
Michael E Wagner, Katherine A Spoth, Lena F Kourkoutis, Syed S H Rizvi
Niosomes were prepared using a novel supercritical carbon dioxide based method to simultaneously encapsulate ferrous sulfate and vitamin D3 as hydrophilic and hydrophobic cargo, respectively. Vesicle particle size was determined to be bimodal with peak diameters of 1.44 ± 0.16 μm and 7.21 ± 0.64 μm, with the smaller peak comprising 98.8% of the total niosomal volume. Encapsulation efficiency of ferrous sulfate was 25.1 ± 0.2% and encapsulation efficiency of vitamin D3 was 95.9 ± 1...
December 2016: Journal of Liposome Research
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