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Journal of Liposome Research

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https://www.readbyqxmd.com/read/29141481/liposome-supported-peritoneal-dialysis-in-rat-amitriptyline-exposure-with-and-without-intravenous-lipid-emulsion
#1
Robin Chapman, Martyn Harvey, Paul Davies, Zimei Wu, Grant Cave
INTRODUCTION: Liposome supported peritoneal dialysis is a recently described technique which may eventually be applicacle in the clinical scenario of the intoxicated patient. We evaluated the hypothesis that intravenous injection lipid emulsion (ILE) would augment acidic pH gradient liposome supported peritoneal dialysis (LSPD). METHODS: Orogastrically amitriptyline dosed rats were treated with either NaHCO3 intravenously and standard intraperitoneal dialysate (A); NaHCO3 intravenously and LSPD (B); or ILE and LSPD (C)...
November 15, 2017: Journal of Liposome Research
https://www.readbyqxmd.com/read/29020849/microfluidic-preparation-of-drug-loaded-pegylated-liposomes-and-the-impact-of-liposome-size-on-tumour-retention-and-penetration
#2
Yao-Da Dong, Estefania Tchung, Cameron Nowell, Sadik Kaga, Nathania Leong, Dharmini Mehta, Lisa M Kaminskas, Ben J Boyd
Understanding the effect of liposome size on tendency for accumulation in tumour tissue requires preparation of defined populations of different sized particles. However, controlling the size distributions without changing the lipid composition is difficult, and differences in compositions itself modify distribution behaviour. Here a commercial microfluidic format as well as traditional methods were used to prepare doxorubicin-loaded liposomes of different size distributions but with the same lipid composition, and drug retention, biodistribution and localization in tumour tissues were evaluated...
October 11, 2017: Journal of Liposome Research
https://www.readbyqxmd.com/read/28922045/monomeric-m2e-antigen-in-vesivax-%C3%A2-liposomes-stimulates-protection-against-type-a-strains-of-influenza-comparable-to-liposomes-with-multimeric-forms-of-m2e
#3
J P Adler-Moore, W Ernst, H Kim, N Ward, S M Chiang, T Do, G Fujii
Given the interest in the ectodomain of the matrix 2 (M2e) channel protein as a target for development of a universal influenza vaccine, we examined the role of the antigen configuration of M2e in generating a protective immune response. A series of M2e mutations and a truncated M2e segment were prepared as a means of controlling the formation of monomer, dimer, and higher order multimeric forms of M2e. Each of these M2e peptides was incorporated into a liposome-based vaccine technology platform previously shown to stimulate a protective response to influenza A infection using M2e as a mixture of monomers, dimers and multimers (L-M2e1-HD/MPL)...
October 5, 2017: Journal of Liposome Research
https://www.readbyqxmd.com/read/28967274/the-care-and-feeding-of-a-commercial-liposomal-product-liposomal-amphotericin-b-ambisome%C3%A2
#4
G M Jensen
AmBisome (liposomal amphotericin B) is among the earliest approved liposomal therapeutics, and has been in commercial use since the early 1990s. This review provides examples of non-clinical, regulatory, clinical label expansion, adverse event management, and supply chain control reflecting the real world challenges of a commercial liposomal therapeutic. We review examples of post-approval clinical development in severe lung infections, development of US and European guidance documents around liposomal therapeutics, the creation of a suitable placebo for blinded clinical trials, response to findings of a possible new category of adverse event (what turned out to be pseudohyperphosphatemia), challenges in handling the finished product in a setting with high risk of exposure of the product to temperatures outside of the established label storage conditions, and elements of continuingly increased aseptic processing requirements for manufacturing...
October 2, 2017: Journal of Liposome Research
https://www.readbyqxmd.com/read/28948854/in-vitro-evaluation-of-archaeosome-vehicles-for-transdermal-vaccine-delivery
#5
Yimei Jia, Michael J McCluskie, Dongling Zhang, Robert Monette, Umar Iqbal, Maria Moreno, Janelle Sauvageau, Dean Williams, Lise Deschatelets, Zygmunt J Jakubek, Lakshmi Krishnan
Archaeosomes composed of archaeal total polar lipids (TPL) or semi-synthetic analog vesicles have been used as vaccine adjuvants and delivery systems in animal models for many years. Typically administered by intramuscular or subcutaneous injections, archaeosomes can induce robust, long-lasting humoral and cell-mediated immune responses against entrapped antigens and provide protection in murine models of infectious disease and cancer. Herein, we evaluated various archaeosomes for transdermal delivery, since this route may help eliminate needle-stick injuries and needle re-use, and therefore increase patient compliance...
September 26, 2017: Journal of Liposome Research
https://www.readbyqxmd.com/read/28874072/liposomal-formulations-in-the-pharmacological-treatment-of-leishmaniasis-a-review
#6
Vanessa Ortega, Selma Giorgio, Eneida de Paula
Conventional chemotherapy for leishmaniasis includes considerably toxic drugs and reports of drug-resistance are not uncommon. Liposomal encapsulated drugs appear as an option for the treatment of leishmaniasis, providing greater efficacy for the active and reducing its side effects by promoting superior tissue absorption, favouring drug penetration into the macrophages, and retarding its clearance from the site of action. In this paper, a review on the advances achieved with liposome-based anti-leishmaniasis drug delivery systems is presented...
September 26, 2017: Journal of Liposome Research
https://www.readbyqxmd.com/read/28920496/spin-rapid-synthesis-purification-and-concentration-of-small-drug-loaded-liposomes
#7
Steven A Roberts, Neil Parikh, Ryan J Blower, Nitin Agrawal
Liposomes are one of the most studied nano-delivery systems. However, only a handful of formulations have received FDA approval. Existing liposome synthesis techniques are complex and specialized, posing a major impediment in design, implementation, and mass production of liposome delivery systems as therapeutic agents. Here, we demonstrate a unique 'synthesis and purification of injectable nanocarriers' (SPIN) technology for rapid and efficient production of small drug loaded liposomes using common benchtop equipment...
September 18, 2017: Journal of Liposome Research
https://www.readbyqxmd.com/read/28920493/construction-and-evaluation-in-vitro-and-in-vivo-of-tedizolid-phosphate-loaded-cationic-liposomes
#8
Zhenlei Yang, Liu Tian, Jingjing Liu, Guihua Huang
Firstly, The SA-TDZA-Lips were prepared by reverse-phase evaporation method. Then, the drug release behavior was evaluated by dynamic membrane dialysis in vitro and the preliminary safety was evaluated by hemolysis method. Finally, with Tedizolid phosphate injection (TDZA-Inj) and tedizolid phosphate loaded liposomes (TDZA-Lips) as the control groups, the pharmacokinetic characteristic and tissues distribution of SA-TDZA-Lips were evaluated after intravenous injection. As a result, the stearylamine modified tedizolid phosphate liposomal delivery system was constructed successfully and the particle size was (194...
September 18, 2017: Journal of Liposome Research
https://www.readbyqxmd.com/read/28874081/physicochemical-investigation-and-in-vivo-activity-of-anti-malarial-drugs-co-loaded-in-tween-80-niosomes
#9
Miloni Thakkar, Brijesh S
Drugs used for the treatment and prevention of malaria are often plagued by the problem of development of resistance. This has hampered their therapeutic efficiency and rendered them ineffective for monotherapy. However, if re-packaged and combined properly, many of these neglected anti-malarial drugs can possibly find their way back into the treatment regime. The present study evaluates the use of curcumin (CC) and primaquine (PRI) as an anti-malarial combination, packaged within niosomes, in comparison to their respective monotherapy options...
September 5, 2017: Journal of Liposome Research
https://www.readbyqxmd.com/read/27667265/quercetin-containing-self-assemble-proliposome-preparation-and-evaluation
#10
Jin Ren, Zhengjie Fang, Liqun Jiang, Qian Du
The purpose of this study was to develop a liquid self-assemble proliposome for quercetin oral delivery. This liquid proliposome was prepared by dissolving phospholipids, surfactants and drug in ethanol. There was only one step in the preparation process of this liquid self-assemble proliposome and no special devices were required. The mechanism about proliposome transformation was discussed. Quercetin proliposomes with different cremorphor RH40 concentrations (0%, 20%, 23%, 26%, 30%) were prepared. The particle size and polydispersity index decreased as cremorphor RH40 concentration increased...
December 2017: Journal of Liposome Research
https://www.readbyqxmd.com/read/27666873/enhancement-of-the-topical-tolnaftate-delivery-for-the-treatment-of-tinea-pedis-via-provesicular-gel-systems
#11
Mona Mahmoud AbouSamra, Alaa Hamed Salama
Tolnaftate is a thiocarbamate antifungal drug which is therapeutically active against dermatophytes that cause various forms of tinea. Due to the small amount of tolnaftate released from ordinary ointment bases and insufficient penetration through the infected skin layers the need to incorporate the drug in a more suitable pharmaceutical form has evolved. A provesicular system is one such form that can solve these problems. Once in contact with the skin, dilution with moisture occurs and the provesicular system rapidly transforms into a vesicular one...
December 2017: Journal of Liposome Research
https://www.readbyqxmd.com/read/27581379/characterization-of-a-liposome-based-artificial-skin-membrane-for-in-vitro-permeation-studies-using-franz-diffusion-cell-device
#12
Hui Zhang, Xuemin Zhu, Jingjing Shen, Haiheng Xu, Min Ma, Wei Gu, Qiudong Jiang, Jun Chen, Jinao Duan
A prerequisite for successful transdermal or dermal drug therapy is the drug ability to penetration through the skin, especially stratum corneum (SC). The most acceptable technique for measuring skin permeation in vitro is the application of both the Franz diffusion cell device and the skin model. In the skin model, a liposome-based artificial skin membrane (LASM) consisting of tight layers of liposomes immobilized on a filter was prepared and characterized. Using porcine ear skin, rat skin and Strat-M™ artificial membrane as control, the LASM was then evaluated in permeation studies with five active compounds: ferulic acid, paeoniflorin, albiflorin, tetrahydrocolumbamine, and tetrahydropalmatine...
December 2017: Journal of Liposome Research
https://www.readbyqxmd.com/read/27581212/reversal-of-p-glycoprotein-mediated-multidrug-resistance-by-doxorubicin-and-quinine-co-loaded-liposomes-in-tumor-cells
#13
Qiying Shen, Liyan Qiu
Multidrug resistance (MDR) is a major obstacle to successful clinical cancer chemotherapy. Currently, there is still unsatisfactory demand for innovative strategies as well as effective and safe reversing agent to overcome MDR. In this study, we developed a novel nanoformulation, in which doxorubicin hydrochloride (DOX) and quinine hydrochloride (QN) were simultaneously loaded into liposomes by a pH-gradient method for overcoming MDR and enhancing cytotoxicity in a doxorubicin-resistant human breast cancer cell line (MCF-7/ADR)...
December 2017: Journal of Liposome Research
https://www.readbyqxmd.com/read/27558522/preparation-and-evaluation-of-niosome-gel-containing-acyclovir-for-enhanced-dermal-deposition
#14
Shery Jacob, Anroop B Nair, Bandar E Al-Dhubiab
Niosomes suggest a versatile vesicle delivery system with possible transport of drugs via topical route for skin delivery. The aim of the present research was to optimize niosome gel formulation of acyclovir and to evaluate in both in vitro and in vivo rabbit model. Niosome formulations were formulated by coacervation phase separation technique with different ratios of nonionic surfactants, phospholipids and cholesterol using 3(2) factorial design. Altering the surfactant concentration has influenced the drug entrapment, but not vesicle size...
December 2017: Journal of Liposome Research
https://www.readbyqxmd.com/read/27386901/cationic-liposomes-produced-via-ethanol-injection-method-for-dendritic-cell-therapy
#15
Micaela Tamara Vitor, Patrícia Cruz Bergami-Santos, Rafael Henrique Freitas Zômpero, Karen Steponavicius Piedade Cruz, Mariana Pereira Pinho, José Alexandre Marzagão Barbuto, Lucimara Gaziola de la Torre
Cationic liposomes can be designed and developed in order to be an efficient gene delivery system for mammalian cells. Dendritic cell (DC) vaccines can be used to treat cancer, as cationic liposomes can deliver tumor antigens to cells while cells remain active. However, most methods used for liposome production are not able to reproduce in large scale the physicochemical and biological properties of liposomes produced in laboratory scale. In this context, ethanol injection method achieved promising results, although requiring post-treatment for size reduction and/or to remove residual ethanol...
December 2017: Journal of Liposome Research
https://www.readbyqxmd.com/read/27367153/characterization-and-in-vitro-evaluation-of-nimotuzumab-conjugated-with-cisplatin-loaded-liposomes
#16
Héctor Vázquez-Becerra, Enrique Pérez-Cárdenas, Saé Muñiz-Hernández, Vanessa Izquierdo-Sánchez, Luis Alberto Medina
In this paper, we report the conjugation of the humanized monoclonal antibody nimotuzumab with cisplatin-loaded liposomes and the in vitro evaluation of its affinity for tumor cells. The conjugation procedure was performed through derivatization of nimotuzumab with N-succinimidyl S-acetylthioacetate (SATA) followed by a covalent attachment with maleimide groups at the end of PEG-DSPE chains located at the membrane of pre-formed liposomes. Confocal microscopy was performed to evaluate the immunoliposome affinity for EGFR antigens from human epidermoid carcinoma (A-431) and normal lung (MRC-5) cell lines...
December 2017: Journal of Liposome Research
https://www.readbyqxmd.com/read/27345333/small-interfering-rna-delivery-into-the-liver-by-cationic-cholesterol-derivative-based-liposomes
#17
Yoshiyuki Hattori, Yoko Machida, Maho Honda, Nozomi Takeuchi, Yuki Yoshiike, Hiroaki Ohno, Hiraku Onishi
PURPOSE: Previously, we reported that the cationic liposomes composed of a cationic cholesterol derivative, cholesteryl (2-((2-hydroxyethyl)amino)ethyl)carbamate (OH-C-Chol) and 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE) (termed LP-C), could deliver small interfering RNAs (siRNAs) with high transfection efficiency into tumor cells. In this study, to develop a liposomal vector for siRNA delivery in vivo, we prepared the poly(ethyleneglycol) (PEG)-modified cationic liposomes (LP-C-PEG) and evaluated their transfection efficiency in vitro and in vivo...
December 2017: Journal of Liposome Research
https://www.readbyqxmd.com/read/27241274/enhancement-of-lomefloxacin-hcl-ocular-efficacy-via-niosomal-encapsulation-in-vitro-characterization-and-in-vivo-evaluation
#18
Rawia M Khalil, Ghada A Abdelbary, Mona Basha, Ghada E A Awad, Hadeer A El-Hashemy
The aim of this study is to develop and evaluate niosomal dispersions loaded with the hydrophilic drug; lomefloxacin Hcl (LXN) for the management of ocular bacterial conjunctivitis. LXN-loaded niosomes were prepared by the thin film hydration method following a full factorial formulation design. Two independent variables were evaluated: the type of surfactant (X1) and the surfactant:cholesterol ratio (X2). The dependent variables comprised entrapment efficiency (EE%: Y1), particle size (PS: Y2) and zeta potential (ZP: Y3)...
December 2017: Journal of Liposome Research
https://www.readbyqxmd.com/read/28480760/tissue-pharmacokinetics-and-pharmacodynamics-of-ambisome%C3%A2-l-ambis-in-uninfected-and-infected-animals-and-their-effects-on-dosing-regimens
#19
J P Adler-Moore, R T Proffitt, J A Olson, G M Jensen
By selecting a unique combination of lipids and amphotericin B, the liposome composition for AmBisome® (L-AmBis) has been optimized resulting in a formulation that is minimally toxic, targets to fungal cell walls, and distributes into and remains for days to weeks in various host tissues at drug levels above the MIC for many fungi. Procedures have been standardized to ensure that large scale production of the drug retains the drug's low toxicity profile, favorable pharmacokinetics and antifungal efficacy. Tissue accumulation and clearance with single or multiple intravenous administration is similar in uninfected and infected animal species, with tissue accumulation being dose-dependent and the liver and spleen retaining the most drug...
September 2017: Journal of Liposome Research
https://www.readbyqxmd.com/read/27601177/ocular-amphotericin-b-delivery-by-chitosan-modified-nanostructured-lipid-carriers-for-fungal-keratitis-targeted-therapy
#20
Tian Fu, Jinglin Yi, Songyi Lv, Bing Zhang
CONTEXT: Fungal keratitis, a corneal fungal infection of the eye caused mainly by Candida species, has become the leading cause of blindness resulting from corneal disease in China. Present limitations in the management of ophthalmic fungal infections include the inability to provide long-term extraocular drug delivery without compromising intraocular structures and/or systemic drug exposure. OBJECTIVE: The aim of this study was to construct amphotericin B (AmB) loaded, chitosan-modified, nanostructured lipid carriers (AmB-CH-NLC) for prolonged ocular application and for the improvement of the targeted delivery of AmB to the ocular mucosa...
September 2017: Journal of Liposome Research
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