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Biosensors & Bioelectronics

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https://www.readbyqxmd.com/read/28324860/direct-detection-of-two-different-tumor-derived-extracellular-vesicles-by-sam-aunis-lspr-biosensor
#1
Abhimanyu Thakur, Guangyu Qiu, Siu-Pang Ng, Jintao Guan, Jianbo Yue, Youngjin Lee, Chi-Man Lawrence Wu
Extracellular vesicles (EVs) are abundant in various biological fluids including blood, saliva, urine, as well as extracellular milieu. Accumulating evidence has indicated that EVs, which contain functional proteins and small RNAs, facilitate intercellular communication between neighbouring cells, and are critical to maintain various physiological processes. In contrast, EV-derived toxic signals can spread out over the tissues adjacent to the injured area in certain diseases, including brain tumors and neurodegenerative disorders...
March 18, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28319905/a-new-amplified-%C3%AF-shape-electrochemical-aptasensor-for-ultrasensitive-detection-of-aflatoxin-b1
#2
Khalil Abnous, Noor Mohammad Danesh, Mona Alibolandi, Mohammad Ramezani, Ahmad Sarreshtehdar Emrani, Reza Zolfaghari, Seyed Mohammad Taghdisi
There is a prompt need for determination of aflatoxin B1 (AFB1) in food products to avoid distribution and consumption of contaminated food products. In this study, an accurate electrochemical sensing strategy was presented for detection of AFB1 based on aptamer (Apt)-complementary strands of aptamer (CSs) complex which forms a π-shape structure on the surface of electrode and exonuclease I (Exo I). The presence of π-shape structure as a double-layer physical barrier allowed detection of AFB1 with high sensitivity...
March 17, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28318777/corrigendum-to-peroxidase-like-activity-of-apoferritin-paired-gold-clusters-for-glucose-detection-biosens-bioelectron-64-2015-165-170
#3
Xin Jiang, Cuiji Sun, Yi Guo, Guangjun Nie, Li Xu
No abstract text is available yet for this article.
March 17, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28324859/bovine-serum-albumin-as-an-effective-sensitivity-enhancer-for-peptide-based-amperometric-biosensor-for-ultrasensitive-detection-of-prostate-specific-antigen
#4
Zhongxue Tang, Yuanyuan Fu, Zhanfang Ma
Bovine serum albumin (BSA) was firstly implemented as an effective sensitivity enhancer for a peptide-based amperometric biosensor for the ultrasensitive detection of prostate specific antigen (PSA). A porous and conductive substrate of chitosan-lead ferrocyanide-(poly(diallyldimethylammonium chloride)-graphene oxide) was in-situ generated on a glassy carbon electrode (GCE), in which Pb2[Fe(CN)6] served as a novel redox species with strong current signal at -0.46 V (vs. Ag/AgCl). Poly(diallyldimethylammonium chloride)-graphene oxide was applied to improve conductivity of the substrate...
March 16, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28324858/dual-lanthanide-doped-complexes-the-development-of-a-time-resolved-ratiometric-fluorescent-probe-for-anthrax-biomarker-and-a-paper-based-visual-sensor
#5
Qi-Xian Wang, Shi-Fan Xue, Zi-Han Chen, Shi-Hui Ma, Shengqiang Zhang, Guoyue Shi, Min Zhang
In this work, a novel time-resolved ratiometric fluorescent probe based on dual lanthanide (Tb: terbium, and Eu: europium)-doped complexes (Tb/DPA@SiO2-Eu/GMP) has been designed for detecting anthrax biomarker (dipicolinic acid, DPA), a unique and major component of anthrax spores. In such complexes-based probe, Tb/DPA@SiO2 can serve as a stable reference signal with green fluorescence and Eu/GMP act as a sensitive response signal with red fluorescence for ratiometric fluorescent sensing DPA. Additionally, the probe exhibits long fluorescence lifetime, which can significantly reduce the autofluorescence interferences from biological samples by using time-resolved fluorescence measurement...
March 16, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28319906/functional-characterization-of-gram-negative-bacteria-from-different-genera-as-multiplex-cadmium-biosensors
#6
Lara Bereza-Malcolm, Sanja Aracic, Ruban Kannan, Gülay Mann, Ashley E Franks
Widespread presence of cadmium in soil and water systems is a consequence of industrial and agricultural processes. Subsequent accumulation of cadmium in food and drinking water can result in accidental consumption of dangerous concentrations. As such, cadmium environmental contamination poses a significant threat to human health. Development of microbial biosensors, as a novel alternative method for in situ cadmium detection, may reduce human exposure by complementing traditional analytical methods. In this study, a multiplex cadmium biosensing construct was assembled by cloning a single-output cadmium biosensor element, cadRgfp, and a constitutively expressed mrfp1 onto a broad-host range vector...
March 16, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28319897/dialysis-membrane-enforced-microelectrode-array-measurement-of-diverse-gut-electrical-activity
#7
Naoko Iwata, Takumi Fujimura, Chiho Takai, Kei Odani, Shin Kawano, Shinsuke Nakayama
A variety of electrical activities occur depending on the functional state in each section of the gut, but the application of microelectrode array (MEA) is rather limited. We thus developed a dialysis membranes-enforced technique to investigate diverse and complex spatio-temporal electrical activity in the gut. Muscle sheets isolated from the gastrointestinal (GI) tract of mice along with a piece of dialysis membrane were woven over and under the strings to fix them to the anchor rig, and mounted on an 8×8 MEA (inter-electrode distance=150µm)...
March 16, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28319896/a-dynamic-sandwich-assay-on-magnetic-beads-for-selective-detection-of-single-nucleotide-mutations-at-room-temperature
#8
Junxiu Wang, Guoliang Xiong, Liang Ma, Shihui Wang, Xu Zhou, Lei Wang, Lehui Xiao, Xin Su, Changyuan Yu
Single-nucleotide mutation (SNM) has proven to be associated with a variety of human diseases. Development of reliable methods for the detection of SNM is crucial for molecular diagnosis and personalized medicine. The sandwich assays are widely used tools for detecting nucleic acid biomarkers due to their low cost and rapid signaling. However, the poor hybridization specificity of signal probe at room temperature hampers the discrimination of mutant and wild type. Here, we demonstrate a dynamic sandwich assay on magnetic beads for SNM detection based on the transient binding between signal probe and target...
March 12, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28315593/ingan-gan-nanowires-as-a-new-platform-for-photoelectrochemical-sensors-detection-of-nadh
#9
M Riedel, S Hölzel, P Hille, J Schörmann, M Eickhoff, F Lisdat
InGaN/GaN nanowire heterostructures are presented as nanophotonic probes for the light-triggered photoelectrochemical detection of NADH. We demonstrate that photogenerated electron-hole pairs give rise to a stable anodic photocurrent whose potential- and pH-dependences exhibit broad applicability. In addition, the simultaneous measurement of the photoluminescence provides an additional tool for the analysis and evaluation of light-triggered reaction processes at the nanostructured interface. InGaN/GaN nanowire ensembles can be excited over a wide wavelength range, which avoids interferences of the photoelectrochemical response by absorption properties of the compounds to be analyzed by adjusting the excitation wavelength...
March 11, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28292558/corrigendum-to%C3%A2-a-split-g-quadruplex-based-dna-nano-tweezers-structure-as-a-signal-transducing-molecule-for-the-homogeneous-detection-of-specific-nucleic-acids-biosens-bioelectron-74-2015-222-226
#10
Keisuke Nakatsuka, Hajime Shigeto, Akio Kuroda, Hisakage Funabashi
No abstract text is available yet for this article.
March 11, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28319899/molecular-imprinting-sensor-based-on-quantum-weak-measurement
#11
Dongmei Li, Qinghua He, Yonghong He, Meiguo Xin, Yilong Zhang, Zhiyuan Shen
A new type of sensing protocol, based on a high precision metrology of quantum weak measurement, was first proposed for molecularly imprinted polymers (MIP) sensor. The feasibility, sensitivity and selectivity of weak measurement based MIP (WMMIP) sensor were experimentally demonstrated with bovine serum albumin (BSA). Weak measurement system exhibits high sensitivity to the optical phase shift corresponding to the refractive index change, which is induced by the specific capture of target protein molecules with its recognition sites...
March 10, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28285197/graphene-oxide-functionalized-long-period-grating-for-ultrasensitive-label-free-immunosensing
#12
Chen Liu, Qi Cai, Baojian Xu, Weidong Zhu, Lin Zhang, Jianlong Zhao, Xianfeng Chen
We explore graphene oxide (GO) nanosheets functionalized dual-peak long period grating (dLPG) based biosensor for ultrasensitive label-free antibody-antigen immunosensing. The GO linking layer provides a remarkable analytical platform for bioaffinity binding interface due to its favorable combination of exceptionally high surface-to-volume ratio and excellent optical and biochemical properties. A new GO deposition technique based on chemical-bonding in conjunction with physical-adsorption was proposed to offer the advantages of a strong bonding between GO and fiber device surface and a homogeneous GO overlay with desirable stability, repeatability and durability...
March 9, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28288447/chemical-redox-modulated-fluorescence-of-nitrogen-doped-graphene-quantum-dots-for-probing-the-activity-of-alkaline-phosphatase
#13
JingJing Liu, Duosi Tang, Zhitao Chen, Xiaomei Yan, Zhou Zhong, Longtian Kang, Jiannian Yao
Alkaline phosphatase (ALP) as an essential enzyme plays an important role in clinical diagnoses and biomedical researches. Hence, the development of convenient and sensitivity assay for monitoring ALP is extremely important. In this work, on the basis of chemical redox strategy to modulate the fluorescence of nitrogen-doped graphene quantum dots (NGQDs), a novel label-free fluorescent sensing system for the detection of alkaline phosphatase (ALP) activity has been developed. The fluorescence of NGQDs is firstly quenched by ultrathin cobalt oxyhydroxide (CoOOH) nanosheets, and then restored by ascorbic acid (AA), which can reduce CoOOH to Co(2+), thus the ALP can be monitored based on the enzymatic hydrolysis of L-ascorbic acid-2-phosphate (AAP) by ALP to generate AA...
March 8, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28285203/flexible-heartbeat-sensor-for-wearable-device
#14
Yeon Hwa Kwak, Wonhyo Kim, Kwang Bum Park, Kunnyun Kim, Sungkyu Seo
We demonstrate a flexible strain-gauge sensor and its use in a wearable application for heart rate detection. This polymer-based strain-gauge sensor was fabricated using a double-sided fabrication method with polymer and metal, i.e., polyimide and nickel-chrome. The fabrication process for this strain-gauge sensor is compatible with the conventional flexible printed circuit board (FPCB) processes facilitating its commercialization. The fabricated sensor showed a linear relation for an applied normal force of more than 930 kPa, with a minimum detectable force of 6...
March 8, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28285200/enhanced-photocurrent-production-by-the-synergy-of-hematite-nanowire-arrayed-photoanode-and-bioengineered-shewanella-oneidensis-mr-1
#15
Gaolong Zhu, Yun Yang, Juan Liu, Feng Liu, Anhuai Lu, Weidong He
Coupling the light-harvesting capabilities of semiconductors with the catalytic power of bacteria is a promising way to increase the efficiency of bioelectrochemical systems. Here, we reported the enhanced photocurrents produced by the synergy of hematite nanowire-arrayed photoanode and the bio-engineered Shewanella oneidensis MR-1 in a solar-assisted microbial photoelectrochemical system (solar MPS) under the visible light. To increase the supply of bioelectrons, the D-lactate transporter, SO1522, was overexpressed in the recombinant S...
March 8, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28319903/fe-iii-based-metal-organic-framework-derived-core-shell-nanostructure-sensitive-electrochemical-platform-for-high-trace-determination-of-heavy-metal-ions
#16
Zhihong Zhang, Hongfei Ji, Yingpan Song, Shuai Zhang, Minghua Wang, Changchang Jia, Jia-Yue Tian, Linghao He, Xiaojing Zhang, Chun-Sen Liu
A new core-shell nanostructured composite composed of Fe(III)-based metal-organic framework (Fe-MOF) and mesoporous Fe3O4@C nanocapsules (denoted as Fe-MOF@mFe3O4@mC) was synthesized and developed as a platform for determining trace heavy metal ions in aqueous solution. Herein, the mFe3O4@mC nanocapsules were prepared by calcining the hollow Fe3O4@C that was obtained using the SiO2 nanoparticles as the template, followed by composing the Fe-MOF. The Fe-MOF@mFe3O4@mC nanocomposite demonstrated excellent electrochemical activity, water stability and high specific surface area, consequently resulting in the strong biobinding with heavy-metal-ion-targeted aptamer strands...
March 7, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28319902/ultra-high-sensitivity-of-the-non-immunological-affinity-of-graphene-oxide-peptide-based-surface-plasmon-resonance-biosensors-to-detect-human-chorionic-gonadotropin
#17
Nan-Fu Chiu, Chia-Tzu Kuo, Ting-Li Lin, Chia-Chen Chang, Chen-Yu Chen
Specific peptide aptamers can be used in place of expensive antibody proteins, and they are gaining increasing importance as sensing probes due to their potential in the development of non-immunological assays with high sensitivity, affinity and specificity for human chorionic gonadotropin (hCG) protein. We combined graphene oxide (GO) sheets with a specific peptide aptamer to create a novel, simple and label-free tool to detect abnormalities at an early stage of pregnancy, a GO-peptide-based surface plasmon resonance (SPR) biosensor...
March 7, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28319900/bipolar-electrochemiluminescence-on-thread-a-new-class-of-electroanalytical-sensors
#18
Rui Liu, Cuiling Liu, Huijie Li, Min Liu, Dan Wang, Chunsun Zhang
This paper introduces a new and simple concept for fabricating low-cost, easy-to-use capillary microchannel (CMC) assisted thread-based microfluidic analytical devices (CMCA-μTADs) for bipolar electrochemiluminescence (BP-ECL) application. The thread with patterns of carbon screen-printed electrodes and bare thread zones (BTZs) is embedded into a CMC. Such CMCA-μTADs can produce a strong and stable BP-ECL signal, and have an extremely low cost ($0.01 per device). Interestingly, the CMCA-μTADs are ultraflexible, and can be bent with a 135° bending angle at the BTZ or with a 150° bending angle at the middle of bipolar electrode (BPE), with no loss of analytical performance...
March 7, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28315592/carbon-quantum-dots-as-fluorescence-resonance-energy-transfer-sensors-for-organophosphate-pesticides-determination
#19
Xiaoli Wu, Yang Song, Xu Yan, Chengzhou Zhu, Yongqiang Ma, Dan Du, Yuehe Lin
Carbon quantum dots (CQDs) obtained from natural organics attract significant attention due to the abundance of carbon sources, varieties of heteroatom doping (such as N, S, P) and good biocompatibility of precursor. In this study, tunable fluorescence emission CQDs originated from chlorophyll were synthesized and characterized. The fluorescence emission can be effectively quenched by gold nanoparticles (Au NPs) via fluorescence resonance energy transfer (FRET). Thiocholine, which was produced from acetylthiocholine (ATC) by the hydrolysis of butyrylcholinesterase (BChE), could cause the aggregation of Au NPs and the corresponding recovery of FRET-quenched fluorescence emission...
March 7, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28288446/hybrid-detection-of-target-sequence-dna-based-on-phosphorescence-resonance-energy-transfer
#20
Yanming Miao, Jinzhi Lv, Guiqin Yan
The severe background fluorescence and scattering light of real biological samples or environmental samples largely reduce the sensitivity and accuracy of fluorescence resonance energy transfer sensors based on fluorescent quantum dots (QDs). To solve this problem, we designed a novel target sequence DNA biosensor based on phosphorescent resonance energy transfer (PRET). This sensor relied on Mn-doped ZnS (Mn-ZnS) room-temperature phosphorescence (RTP) QDs/poly-(diallyldimethylammonium chloride) (PDADMAC) nanocomposite (QDs(+)) as the energy donor and the single-strand DNA-ROX as the energy receptor...
March 7, 2017: Biosensors & Bioelectronics
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