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European Journal of Gastroenterology & Hepatology

Ayman Alsebaey, Mostafa Elhelbawy, Imam Waked
BACKGROUND: Hepatitis C virus (HCV) is a global health problem that is complicated by liver fibrosis and insulin resistance (IR). AIM: The aim of this study was to validate neutrophils-to-lymphocytes ratio (NLR) and platelets-to-lymphocytes ratio (PLR) as indirect biomarkers of liver fibrosis and IR in HCV patients. PATIENTS AND METHODS: One hundred and fifty patients were enrolled. Physical examination, BMI, liver function tests, serum creatinine, complete blood count, serum HCV RNA count by PCR, and abdominal ultrasonography were performed...
December 13, 2017: European Journal of Gastroenterology & Hepatology
Judith A Kwakman, Catharina J van Oostveen, Karlijn J van Stralen, Eva Cleeren, Maarten Neerinx, René W M van der Hulst
OBJECTIVE: Current guidelines recommend a gastroduodenoscopy (GDS) and colonoscopy in patients with iron-deficiency anemia (IDA). However, in daily practice, patients with nonferriprive anemia are also referred for endoscopy. The aim of this study is to compare the diagnostic yield of colonoscopy and GDS in patients with IDA and non-IDA. PATIENTS AND METHODS: A retrospective single-center cohort study was carried out from January 2013 till February 2016 that included 917 patients with anemia...
December 12, 2017: European Journal of Gastroenterology & Hepatology
Benjamin Nulsen, Bruce E Sands, Brijen J Shah, Ryan C Ungaro
OBJECTIVE: Cigarette smoking is one of the most important, modifiable environmental factors in Crohn's disease (CD) and screening for tobacco use is an official recommendation and quality measure in the care of CD patients. The objective of this study was to learn more about gastroenterologists' practices, opinions, and knowledge in this area. PATIENTS AND METHODS: A 15 question survey was sent through email to two national gastroenterology distribution lists. Questions were written in multiple choice formats and were designed to collect information about gastroenterologists' practices, attitudes, and knowledge regarding smoking cessation in CD patients...
December 12, 2017: European Journal of Gastroenterology & Hepatology
Ann E Almazar, Nicholas J Talley, Joseph J Larson, Elizabeth J Atkinson, Joseph A Murray, Yuri A Saito
BACKGROUND AND AIMS: Routine serologic testing for celiac disease (CD) may be useful in irritable bowel syndrome (IBS) patients, but this is controversial. We aimed to compare the prevalence of unrecognized CD in a large cohort of patients with and without IBS. PARTICIPANTS AND METHODS: This is a family case-control IBS study conducted at a single US academic medical center. Stored serum and DNA were available. Tissue transglutaminase (TTg) immunoglobulin A was performed, followed by indirect immunofluorescence testing for endomysial antibodies with positive or weakly positive TTg results...
December 12, 2017: European Journal of Gastroenterology & Hepatology
Xiuyun Ai, Weiguang Qiao, Zemin Han, Wenxin Tan, Yang Bai, Side Liu, Fachao Zhi
BACKGROUND: Screening colonoscopy is less effective in preventing proximal colon cancers than distal colon cancers. A repeat examination of the right side of the colon may increase the lesion detection. The study aimed to assess the results of a second examination of the right side of the colon with forward-view or retroflexion colonoscopy performed immediately after the initial examination. MATERIALS AND METHODS: We carried out a meta-analysis of all primary studies that performed a second examination of the right side of the colon with forward-view or retroflexion colonoscopy performed immediately after the initial examination...
December 11, 2017: European Journal of Gastroenterology & Hepatology
Andrei M Voiosu, Signe Wiese, Theodor A Voiosu, Jens Hove, Flemming Bendtsen, Søren Møller
BACKGROUND AND AIMS: Bile acids (BAs) are potent signaling molecules involved in the regulation of several metabolic and functional aspects of cardiovascular homeostasis. BA pool alteration in cirrhosis may contribute toward the development of hemodynamic and cardiac disturbances. We aimed to investigate the association between total BA levels and echocardiographic and biochemical markers of cardiac dysfunction in cirrhotic patients. METHODS: Cirrhotic patients were enrolled prospectively in this hypothesis-generating study and evaluated for cardiac and hemodynamic dysfunction through clinical, echocardiographic, and biochemical means...
December 8, 2017: European Journal of Gastroenterology & Hepatology
Michele De Lemos-Bonotto, Cristiane Valle-Tovo, Ane M Costabeber, Angelo A Mattos, André L F Azeredo-da-Silva
INTRODUCTION: The gold-standard treatment for autoimmune hepatitis (AIH) is a prednisone/azathioprine combination. However, subgroups of patients may be unresponsive to this treatment. The aim of this study is to evaluate the efficacy of second-line immunosuppressive therapies for AIH through a systematic review and meta-analysis in adult patients. PATIENTS AND METHODS: The systematic review was registered at the PROSPERO platform under number 42015019831. Databases MEDLINE (PubMed), Lilacs, Cochrane, and Scielo were searched...
December 8, 2017: European Journal of Gastroenterology & Hepatology
Amnon Sonnenberg
BACKGROUND AND AIM: Endoscopic procedures of the gastrointestinal tract represent a category of diagnostic tests that considerably rely on skills and dexterity of a human tester. The present analysis aimed to delineate factors that affect the success of teaching endoscopy and potentially limit the acquisition of new skills and knowledge. METHODS: The performance of the endoscopist is described in terms of sensitivity and specificity. The outcomes of sequential testing and acquisition of new knowledge are calculated using matrix algebra...
December 8, 2017: European Journal of Gastroenterology & Hepatology
Wei-Zhe Chen, Xi-Yi Chen, Feng-Min Zhang, Qian-Tong Dong, Yan-Bin Ji, Xiao-Lei Chen, Cheng-Le Zhuang, Xiao-Xi Chen
BACKGROUND/AIM: The aim of this prospective double-center study was to explore the effect of nutritional risk on short-term outcomes in the patients who had gastric cancer and underwent a laparoscopic-assisted gastrectomy. PATIENTS AND METHODS: We conducted a study of patients who underwent laparoscopic-assisted gastrectomy in two large centers between June 2014 and April 2017. Patients' demographic and clinical characteristics and postoperative short-term outcomes were prospectively analyzed...
December 8, 2017: European Journal of Gastroenterology & Hepatology
Karn Wijarnpreecha, Charat Thongprayoon, Melissa Scribani, Patompong Ungprasert, Wisit Cheungpasitporn
BACKGROUND/AIMS: Studies have shown that nonalcoholic fatty liver disease (NAFLD) is associated with an increased risk of chronic kidney disease (CKD). However, it is unknown whether severe liver fibrosis is associated with a higher prevalence of CKD among NAFLD. We examined the diagnostic performance of noninvasive fibrosis markers in identifying prevalent CKD among NAFLD. METHODS: This study represents an analysis of the National Health and Nutrition Examination Survey conducted in the USA between 1988 and 1994...
December 5, 2017: European Journal of Gastroenterology & Hepatology
Jens Walldorf, Susanne Brunne, Fleur S Gittinger, Patrick Michl
OBJECTIVE: Inflammatory bowel disease (IBD) frequently affects women when family planning and pregnancy (FPP) are important issues. This survey aimed to identify patients with an increased need for medical counselling. PATIENTS AND METHODS: An internet-based questionnaire was offered to women with IBD. Characteristics in terms of FPP were analysed with respect to sociodemographic and disease-related factors. RESULTS: Childlessness was frequently reported (64...
December 5, 2017: European Journal of Gastroenterology & Hepatology
Claudia Mescoli, Aly Gallo Lopez, Luis Taxa Rojas, Walker Jove Oblitas, Matteo Fassan, Massimo Rugge
The elective background for gastric adenocarcinoma is the atrophic transformation of the gastric mucosa. The extent of mucosal atrophy basically parallels the risk of developing gastric cancer. This means that either noninvasive (serology) or invasive (endoscopy/histology) methods enabling the atrophic transformation to be quantified can be used theoretically to assess a given patient's gastric cancer risk. This review aims to focus on the reliability of histology gastritis Operative Link for Gastritis Assessment -staging system for assessing the 'personalized' cancer risk in individuals with (atrophic) gastritis...
December 5, 2017: European Journal of Gastroenterology & Hepatology
Clara Castro, Mário Dinis-Ribeiro, António N G Rodrigues, Tiago Calheiros, João Santos, Pedro Pereira, Mariana Ramos, Hugo Cunha, Mara Andrade, Anita Costa, Ligia Sá, Luís Antunes, Maria J Bento, Rafael Lomba-Viana
BACKGROUND: Even though mass gastric cancer screening is controversial in Western countries, diverse strategies have been proposed in intermediate-risk to high-risk areas. AIM: The aim of this study was to determine the long-term accuracy of the pepsinogen test (PG) for early diagnosis of gastric cancer. PARTICIPANTS AND METHODS: A cohort of inhabitants from the Northern part of Portugal, aged between 40 and 74 years (n=5913), subjected to the PG test (PGI≤70 ng/ml and PGI/PGII≤3), were followed up between November 2006 and December 2015...
December 5, 2017: European Journal of Gastroenterology & Hepatology
Tao Zhang, Kewei Sun, Ya Wang, Lei Huang, Ren Lang, Wei Jiang
Acute-on-chronic liver failure (ACLF) is characterized by organ failure mediated by acute decompensation of cirrhosis. Recent studies have highlighted the importance of the gut-liver axis (GLS) and its association with ACLF pathogenesis. In this review, we discuss the mechanisms related to the alteration of the GLA and their involvement in ACLF pathogenesis and suggest some possible therapeutic options that could modulate the GLA dysfunction. This knowledge may provide information useful for the design of therapeutic strategies for gut dysbiosis and its complications in ACLF...
December 1, 2017: European Journal of Gastroenterology & Hepatology
Muhammad H Bashir, Javid Fazili, Mohammad F Madhoun, Rajesh Kanagala, Sixia Chen, Salman Nusrat
BACKGROUND: Hepatitis C virus (HCV) is a common cause of cirrhosis, leading to increased morbidity and mortality. Treatment of the underlying etiology has been shown to improve fibrosis and cirrhosis. AIM: We sought to evaluate the impact of a sustained virologic response on liver chemistries, model for end stage liver disease (MELD) score, Child-Pugh-Turcotte score (CPT), and fibrosis 4 score (FIB4) in patients with liver cirrhosis secondary to HCV with portal hypertension, with or without decompensation...
December 1, 2017: European Journal of Gastroenterology & Hepatology
Przemysław Holko, Paweł Kawalec, Małgorzata Mossakowska
OBJECTIVES: Novel oral treatments (including biologics) of inflammatory bowel disease (IBD) are emerging. Apart from improvement of health, treatment convenience may be of value to patients. This 'process utility' can be estimated under the quality-of-life framework. We investigated the process utility associated with subcutaneous and intravenous biologic treatments compared with a hypothetical oral biologic treatment of IBD. MATERIALS AND METHODS: A time trade-off study to estimate utilities for health states among adult patients with IBD was carried out...
November 29, 2017: European Journal of Gastroenterology & Hepatology
Ziyu Lin, Jing Liang, Jianyun Zhu, Chaoxia Hu, Yurong Gu, Jing Lai, Yubao Zheng, Zhiliang Gao
BACKGROUND: Several fibrosis-related factors influence liver stiffness measurements (LSM); however, these changes have not been investigated in the context of the various disease stages of chronic hepatitis B (CHB). AIM: The aim of this study was to assess the correlations between fibrosis-related factors and LSM in different disease stages of CHB. PATIENTS AND METHODS: Patients with mild CHB (n=305) and cirrhotic hepatitis B (cirrhotic HB) (n=137) were compared with determine the relationship between LSM and fibrosis-related factors including parameters of liver inflammation [aminotransferase (ALT), aspartate transaminase (AST), total bilirubin (Tbil)], albumin, globulin, peripheral blood cells (neutrophil granulocytes, red blood cells, platelets), abdominal ultrasound B-scan parameters including right liver thickness, portal vein inradium, diameter of spleen (DS), thickness of spleen (TS), and splenic vein inradium (SV)...
November 29, 2017: European Journal of Gastroenterology & Hepatology
Xintong Zhang, Xingshun Qi, Eric M Yoshida, Méndez-Sánchez Nahum, Feifei Hou, Han Deng, Xiaoxi Wang, Jing Qiu, Chao He, Shuang Wang, Xiaozhong Guo
BACKGROUND AND AIMS: Patients with cirrhosis are reportedly more prone to develop hemorrhagic stroke, thereby increasing the risk of death. However, the effect of ischemic stroke on liver diseases remains unclear. In addition, few studies have explored the risk factors for ischemic stroke in patients with liver cirrhosis. Our study aimed to explore the epidemiology, risk factors, and in-hospital outcomes of ischemic stroke in a large cohort of hospitalized patients with cirrhosis. PATIENTS AND METHODS: In this single-center observational study, we retrospectively reviewed the medical records of patients with liver cirrhosis admitted to our hospital from January 2011 to June 2014...
November 17, 2017: European Journal of Gastroenterology & Hepatology
Joana R Carvalho, Samuel R Fernandes, Patrícia Santos, Carlos M Moura, Teresa Antunes, José Velosa
BACKGROUND: Acute pancreatitis (AP) is an aggressive and potentially fatal clinical condition. Although all age groups are at risk, the elderly may be a group of special concern. We aimed at evaluating clinical outcomes of patients with elderly-onset AP. MATERIALS AND METHODS: Using a single-center retrospective database, treatment and follow-up records of 550 patients admitted with AP were reviewed. Outcomes included mortality, admission to the ICU, need for interventional procedures, nutritional support, and length of hospital and ICU stay...
November 17, 2017: European Journal of Gastroenterology & Hepatology
Andrew T Kunzmann, Úna C McMenamin, Andrew D Spence, Ronan T Gray, Liam J Murray, Richard C Turkington, Helen G Coleman
BACKGROUND: Oesophageal cancer prognosis remains poor owing to the inability to detect the disease at an early stage. Nontissue (serum, urinary or salivary) biomarkers potentially offer less invasive methods to aid early detection of oesophageal cancer. We aimed to systematically review studies assessing the relationship between nontissue biomarkers and subsequent development of oesophageal cancer. METHODS: Using terms for biomarkers and oesophageal cancer, Medline, EMBASE and Web of Science were systematically searched for longitudinal studies, published until April 2016, which assessed the association between nontissue biomarkers and subsequent oesophageal cancer risk...
November 17, 2017: European Journal of Gastroenterology & Hepatology
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