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European Journal of Gastroenterology & Hepatology

Feng Zhang, Hui Xu, Min Chen, Ming Zhang, Jiangqiang Xiao, Yi Wang, Qibin He, Wei Zhang, Xiaochun Yin, Xiaoping Zou, Yuzheng Zhuge
OBJECTIVE: Propranolol is always titrated to the maximum tolerated dose to prevent gastroesophageal variceal bleeding. However, some patients do not achieve a hemodynamic response and experience more intolerance and discontinuation. This study evaluated the dose-dependent effect of propranolol on hemodynamic response and tolerance in cirrhotic patients. PATIENTS AND METHODS: This retrospective study included 95 consecutive patients recruited from our prospective database...
November 12, 2018: European Journal of Gastroenterology & Hepatology
Shu-Ling Wang, Qian Wang, Jun Yao, Sheng-Bing Zhao, Li-Sheng Wang, Zhao-Shen Li, Yu Bai
OBJECTIVE: Adequate bowel preparation is essential for a successful colonoscopy; clinical studies suggest reinforced education can improve the preparation process. However, there have been no trials to compare WeChat directions (the most widely used social media app in China) with those of the short message service (SMS). This study was aimed to assess the effect of WeChat and SMS on the bowel preparation quality. PARTICIPANTS AND METHODS: This was a single-center, prospective, endoscopically blinded, randomized, controlled study...
November 8, 2018: European Journal of Gastroenterology & Hepatology
Xavier J N M Smeets, Iris Knoester, Karina V Grooteman, Vikesh K Singh, Peter A Banks, Georgios I Papachristou, Andres Duarte-Rojo, Guillermo Robles-Diaz, Wietske Kievit, Marc G H Besselink, Robert C Verdonk, Hjalmar C Van Santvoort, Joost P H Drenth, Michael Belias, Erwin J M Van Geenen
OBJECTIVES: There are data to suggest that obesity is associated with local and systemic complications as well as mortality in acute pancreatitis (AP). Cohort studies to date, however, have shown conflicting results from mostly unadjusted analyses. Therefore, we performed an individual patient data meta-analysis with the primary aim to investigate the association between obesity and mortality in AP. Our secondary aim was to investigate the association between obesity and necrosis, organ failure, multiple organ failure, and invasive intervention...
November 5, 2018: European Journal of Gastroenterology & Hepatology
Shemal M Shah, Jagat B Baniya, Birendra Prasad Gupta, Ananta Shrestha, Holly Rodin, Andre Boonstra, Jose D Debes
OBJECTIVE: Hepatitis E virus (HEV) seropositivity may confer an increased risk of liver fibrosis in immunosuppressed individuals. We studied this effect in HIV-infected individuals in Nepal, a country hyperendemic for HEV. PARTICIPANTS AND METHODS: We prospectively evaluated 200 HIV-positive individuals. Serum samples were tested for components of fibrosis scores and cytokeratin-18. RESULTS: Of 200 patients, 43% were HEV-immunoglobulin G+...
November 5, 2018: European Journal of Gastroenterology & Hepatology
Tan Attila, Volkan Adsay, Douglas O Faigel
Endoscopic ultrasound (EUS)-guided pancreatic cyst ablation with alcohol lavage or paclitaxel-based regimens are investigative modalities. To evaluate the safety and efficacy of EUS-guided pancreatic cyst ablation with alcohol lavage or paclitaxel-based regimens. A systematic review of computerized bibliographic databases was carried out for studies of EUS-guided pancreatic cyst ablation with alcohol lavage or paclitaxel-based regimens from January 1980 to February 2018. EUS-guided cyst ablation-related outcomes (cyst resolution) and complications...
November 2, 2018: European Journal of Gastroenterology & Hepatology
Michael P Jones, Susanna Walter, Åshild Faresjö, Ewa Grodzinsky, Lars Kjellström, Lisa Viktorsson, Nicholas J Talley, Lars Agreus, Anna Andreasson
BACKGROUND: Clinical understanding of gastrointestinal symptoms is commonly based on patient reports of symptom experience. For diagnosis and treatment choices to be appropriate, symptom reports need to be accurate. We examined the agreement between questionnaire recall and prospective diary enumeration of symptoms relevant to the irritable bowel syndrome. PATIENTS AND METHODS: Data are reported from a randomly selected general population sample (n=238) and also a primary healthcare centre (PHC) sample (n=503, 10 PHCs)...
November 2, 2018: European Journal of Gastroenterology & Hepatology
Muhammad Shahid, Muhammad Idrees, Azeem M Butt, Syed M Raza, Iram Amin, Afza Rasul, Samia Afzal, Sadia Zahid, Rabia Nawaz
INTRODUCTION: Hepatitis G virus (HGV) infection appears to be common in patients with chronic hepatitis C virus (HCV) infection. The aim of this study was to investigate the prevalence of HCV/HGV in patients with chronic hepatitis C (CHC) in Pakistan and to look for possible associations with various clinical and histopathological changes in HCV/HGV coinfection and HCV infection. PATIENTS AND METHODS: The present study included 136 patients. Clinical, biochemical, virological and histological findings were compared between patients coinfected with HCV/HGV and patients with HCV alone...
October 31, 2018: European Journal of Gastroenterology & Hepatology
Duo-Duo Lv, Meng-Lan Wang, En-Qiang Chen, Dong-Bo Wu, Ya-Chao Tao, Dong-Mei Zhang, Hong Tang
BACKGROUND: A combination of sofosbuvir (SOF)+NS5A inhibitor therapies is the main treatment for patients with hepatitis C virus (HCV) genotype-2 (GT-2) chronic infection, but the data are rarely reported in China. This study aimed to investigate the virological response and liver fibrosis improvement among GT-2 patients receiving SOF+NS5A inhibitors. PATIENTS AND METHODS: In this retrospective study, patients who received SOF+NS5A inhibitors between March 2016 and July 2017 were recruited...
October 31, 2018: European Journal of Gastroenterology & Hepatology
Matt Driedger, Chrissi Galanakis, Mary-Anne Doyle, Curtis L Cooper
OBJECTIVE: Hepatitis C virus (HCV), cirrhosis, and HCV medications including direct-acting antivirals (DAAs) ±ribavirin may all influence the metabolic milieu. While interferon-based regimens improve glucose tolerance, evidence is limited on DAAs. Cases of elevated lactate have recently been reported in patients treated with DAAs, and lactic acidosis is a known complication of antivirals used to treat hepatitis B virus and HIV. PATIENTS AND METHODS: Measures were evaluated at baseline, week 4, end of treatment, and 12-24 weeks after treatment...
October 30, 2018: European Journal of Gastroenterology & Hepatology
Rita S Costa, Ana F Cardoso, Anibal Ferreira, Juliana Costa, Dalila Costa, Dália Fernandes, Ana C Caetano
INTRODUCTION: Percutaneous liver biopsy (PLB) is an invasive procedure used for the assessment of liver diseases. The patient's recovery position after the PLB differs among hospitals and departments. This study aims to evaluate adverse events and patient acceptability according to the recovery position adopted after the PLB. PATIENTS AND METHODS: From September 2014 to March 2017, patients submitted to PLB were randomly assigned to a recovery position arm: right-side position (RRP), dorsal position (DRP), or combined position...
October 24, 2018: European Journal of Gastroenterology & Hepatology
Tariq Shah, Wajid Hussain, Niyaz Ali, Sadia Sardar, Muhammad Ishaq, Mujaddad Ur Rahman, Luming Ding, Sadia Qayyum, Ibrar Khan
BACKGROUND: Thalassemia is a group of inherited hematological disorders caused by mutation in globin's genes. Regular blood transfusion lengthens the life of thalassemia patients but it carries a definite risk of the infections of blood-borne diseases. AIM/OBJECTIVE: The current study was carried out for the frequency distributions and risk factors of hepatitis B virus (HBV) and hepatitis C virus (HCV) infections among thalassemia patients in Hazara regions, Pakistan...
October 24, 2018: European Journal of Gastroenterology & Hepatology
Ai Murata, Hideyuki Hyogo, Michihiro Nonaka, Akihiko Sumioka, Yosuke Suehiro, Akira Furudoi, Yoshifumi Fujimoto, Yasuyuki Aisaka, Hironao Komatsu, Hironori Tokumo
INTRODUCTION: Muscle cramps are common comorbidities in chronic liver disease (CLD). Although the prevalence of these has been reported in patients with liver cirrhosis (LC), that of CLD is unknown. In this study, we aimed to clarify the prevalence and characteristics of muscle cramps in individual CLD. PATIENTS AND METHODS: A total of 432 patients with CLD who visited our hospital were enrolled. The existence of muscle cramps, frequency, time zone, duration, and the degree of pain were investigated using a medical interview questionnaire...
October 22, 2018: European Journal of Gastroenterology & Hepatology
Hamzah Abu-Sbeih, Kati Choi, Cynthia N Tran, Xuemei Wang, Phillip Lum, Gladis Shuttlesworth, John R Stroehlein, Pablo C Okhuysen, Yinghong Wang
BACKGROUND: Cancer patients are susceptible to recurrent Clostridium difficile infection (CDI) that is increasing globally, necessitating new approaches to prevent fatal consequences. We examined the clinical characteristics of cancer patients with recurrent CDI (RCDI). PATIENTS AND METHODS: A retrospective review of cancer patients with C. difficile-positive test between January 2015 and May 2017 was carried out. CDI was defined as diarrhea and toxigenic C. difficile detection in the stool by nucleic acid amplification test and enzyme immunoassay...
October 18, 2018: European Journal of Gastroenterology & Hepatology
Raquel Ballester-Clau, Gisela Torres Vicente, Tania Voltà-Pardo, Laura López-Barroso, Mercedes Cucala-Ramos, Josep M Reñé-Espinet, Montse Planella de Rubinat
OBJECTIVE: The aim of this study was to assess the efficacy and safety of intravenous ferric carboxymaltose (FCM) following hospitalization for acute gastrointestinal bleeding (AGIB) in the context of a restrictive transfusion strategy. PATIENTS AND METHODS: A retrospective single-center study analyzed patients with AGIB (excluding AGIB secondary to portal hypertension) administered a single FCM dose with or without blood transfusion. RESULTS: Eighty-six episodes in 84 patients were analyzed...
October 17, 2018: European Journal of Gastroenterology & Hepatology
P Aiden McCormick, Dermot E Malone, James R Docherty, Clifford Kiat, Brian T Christopher, Jun Liong Chin
OBJECTIVES: One of the striking features of splenic imaging is variable heterogeneous gyriform arterial enhancement on dynamic computed tomography (CT). We speculated that these patterns of arterial enhancement may reflect changes in splenic micro-circulation related to changes in portal venous pressure. PATIENTS AND METHODS: To test this hypothesis, we evaluated arterial phase CT scans performed before and after liver transplantation (n=91), as this is the most effective way of alleviating portal hypertension...
October 16, 2018: European Journal of Gastroenterology & Hepatology
Kathrin Krüger, Christian Krauth, Siegbert Rossol, Stefan Mauss, Klaus H W Boeker, Tobias Müller, Hartwig Klinker, Anita Pathil, Renate Heyne, Jona T Stahmeyer
OBJECTIVE: Chronic hepatitis C virus infection is associated with a significant health burden. Long-term consequences are the development of liver cirrhosis and hepatocellular carcinoma. The introduction of direct-acting antivirals (DAA) has led to an increase in sustained virologic response rates (SVR), but is accompanied by higher treatment costs. The aim of this study was to assess the outcomes and costs of treating hepatitis C virus infected patients with DAAs in clinical practice in Germany...
October 15, 2018: European Journal of Gastroenterology & Hepatology
Barbara Kern, Benedikt Feurstein, Josef Fritz, Cornelia Fabritius, Robert Sucher, Ivo Graziadei, Reto Bale, Herbert Tilg, Heinz Zoller, Philip Newsome, Stephan Eschertzhuber, Raimund Margreiter, Dietmar Öfner, Stefan Schneeberger
BACKGROUND AND AIMS: Nonalcoholic steatohepatitis (NASH) is an increasingly prevalent indication for liver transplantation (LT) across the world. The relative outcomes following transplantation are poorly described in this cohort. We aimed to analyze the incidence and outcome of LT for NASH as compared with other indications. PATIENTS AND METHODS: This is a retrospective analysis of 513 patients who underwent deceased-donor, adult LT between 2002 and 2012 as recorded at the Medical University of Innsbruck, Austria...
October 12, 2018: European Journal of Gastroenterology & Hepatology
Ayman Yosry, Zeinab A Soliman, Rasha Eletreby, Iman Hamza, Alaa Ismail, Mohammad A Elkady
BACKGROUND AND AIMS: Albumin infusion reduces the incidence of postparacentesis circulatory dysfunction among patients with cirrhosis and tense ascites compared with no treatment. Less costly treatment alternatives such as vasoconstrictors have been investigated, but the results are controversial. Midodrine, an oral α1-adrenergic agonist, increases effective circulating blood volume and renal perfusion by increasing systemic and splanchnic blood pressure. Our aim is to assess whether or not morbidity in terms of renal dysfunction, hyponatremia, systemic, or portal hemodynamics derangement or mortality differed in patients receiving albumin versus midodrine...
October 11, 2018: European Journal of Gastroenterology & Hepatology
Ta-Ya Lin, Ming-Lun Yeh, Chung-Feng Huang, Ching-I Huang, Chia-Yen Dai, Meng-Hsuan Hsieh, Shinn-Chern Chen, Jee-Fu Huang, Ming-Lung Yu, Wan-Long Chuang
OBJECTIVES: Nonalcoholic steatohepatitis (NASH) might progress to fibrosis, cirrhosis, and hepatocellular carcinoma. However, the natural history of NASH has not been fully clarified. This study aimed to investigate the disease progression in NASH patients receiving paired liver biopsies. We also aimed to examine the factors associated with NASH progression. PATIENTS AND METHODS: Ten NASH patients who had received liver biopsies during June 2001 and February 2010 were consecutively enrolled...
October 10, 2018: European Journal of Gastroenterology & Hepatology
Cristina Verdejo, Daniel Hervías, Óscar Roncero, Ángel Arias, Abdelmouneim Bouhmidi, Rufo Lorente, Irina Salueña, Alfredo J Lucendo
BACKGROUND: Fecal calprotectin (FC) is a widely used noninvasive marker of gut inflammation that is associated with endoscopic severity in Crohn's disease (CD). However, FC has been inconsistent in predicting postoperative recurrence of CD, and its utility in the postoperative setting remains unclear. MATERIALS AND METHODS: Blood and fecal samples were collected in consecutively recruited patients with CD who had undergone ileocolonic resection and required a colonoscopy to assess postoperative recurrence, as defined by the Rutgeerts score (RS)...
October 9, 2018: European Journal of Gastroenterology & Hepatology
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