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European Journal of Gastroenterology & Hepatology

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https://www.readbyqxmd.com/read/28538269/novel-therapies-and-potential-therapeutic-targets-in-the-management-of-chronic-hepatitis-b
#1
Joao M Serigado, Manhal Izzy, Harmit Kalia
Chronic hepatitis B is a persistent and progressive inflammatory liver disease caused by infection with the hepatitis B virus (HBV). More than 240 million individuals are infected with HBV worldwide and hepatitis B accounts for an estimated 650 000 deaths annually. Approximately up to 30% of chronically infected patients will develop complications of HBV infection including, but not limited to, liver cirrhosis, end-stage liver disease, and hepatocellular carcinoma. Currently approved therapies have improved clinical outcomes, but have a considerable side-effect profile, elevated cost, and a finite course of treatment...
May 19, 2017: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28538268/etiological-factors-of-chronic-hepatitis-in-italy-a-2014-national-survey
#2
Tommaso Stroffolini, Evangelista Sagnelli, Piero L Almasio, Angelo Andriulli, Antonina Smedile, Mario Pirisi, Caterina Sagnelli, Maurizio Russello, Nicola Coppola, Massimo de Luca, Mariantonietta Pisaturo, Floriano Rosina, Giovanni B Gaeta
BACKGROUND: The last Italian prevalence survey on chronic hepatitis (CH) conducted in 2001 showed that the hepatitis C virus (HCV) was the main agent associated with CH. AIM: The aim of this study was to evaluate epidemiological changes in CH occurring after 13 years. PATIENTS AND METHODS: Enrollment of 1392 CH consecutive patients referred to 16 Italian liver units in 2014 scattered all over the country (four in the North, four in the Center, four in the South, and four in the Islands) was performed...
May 19, 2017: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28538267/cirrhosis-has-no-impact-on-therapeutic-responses-of-entecavir-for-chronic-hepatitis-b
#3
Pin-Chao Wang, Tao-Yang Wei, Tai-Chung Tseng, Hans Hsienhong Lin, Chia-Chi Wang
OBJECTIVE: As the efficacy of a direct antiviral agent is reduced in cirrhotic chronic hepatitis C patients, prolonged duration of treatment or addition of ribavirin is recommended to improve the rates of sustained virological response. However, the impact of cirrhosis on the efficacy of antiviral treatment for chronic hepatitis B (CHB) remained unclear. PATIENTS AND METHODS: This retrospective cohort study screened entecavir (ETV)-treated CHB patients in Taipei Tzu Chi Hospital from January 2007 till October 2014...
May 19, 2017: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28520575/predictors-of-bile-tree-pathology-in-patients-presenting-with-gallbladder-disease
#4
Mahmoud A Rahal, Mohammad O Rammal, Walid Karaoui, Ali Hallal, Hani Tamim, Yasser Shaib
BACKGROUND: Patients with gallstone disease can present with elevated liver function tests (LFTs). It is often challenging to differentiate those with a common bile duct (CBD) stone from those without a CBD stone on the basis of the LFTs levels. In this study, we aim to evaluate the predictors of a CBD stones among patients presenting with symptomatic gallbladder disease and elevated LFTs. PATIENTS AND METHODS: We retrospectively examined all patients who had undergone a cholecystectomy between January 2010 and December 2015...
May 17, 2017: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28520574/orthotopic-liver-transplantation-changes-the-course-of-gastric-antral-vascular-ectasia-a-case-series-from-a-transplant-center
#5
Chaitanya Allamneni, Basem Alkurdi, Rehan Naseemuddin, Brendan M McGuire, Mohamed G Shoreibah, Devin E Eckhoff, Shajan Peter
BACKGROUND AND AIM: Gastric antral vascular ectasia (GAVE) is an important cause of upper gastrointestinal bleeding and anemia in patients with cirrhosis. The aim of our study was to evaluate the effect of orthotopic liver transplantation (OLT) on GAVE and associated anemia. PATIENTS AND METHODS: We performed a chart review and identified all cirrhotic patients with GAVE who underwent OLT at the University Of Alabama at Birmingham between 2005 and 2013. Population's demographics, etiology of cirrhosis, comorbidities, presentation and treatment modalities of GAVE, endoscopic and histopathologic reports, hemoglobin values before and after transplant, and immunosuppressive regimens were collected...
May 17, 2017: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28509677/stool-cytomegalovirus-polymerase-chain-reaction-for-the-diagnosis-of-cytomegalovirus-related-gastrointestinal-disease
#6
Noparat Prachasitthisak, Pornthep Tanpowpong, Chatmanee Lertudomphonwanit, Suporn Treepongkaruna, Sophida Boonsathorn, Napat Angkathunyakul, Pattana Sornmayura, Wasun Chantratita
OBJECTIVES: The diagnosis of cytomegalovirus-related gastrointestinal disease (CMV-GI disease) still requires histopathology, but biopsy is considered invasive. Stool CMV PCR has been reported in adults as an alternative method to diagnose this condition; hence, the results between studies are discrepant. Moreover, no pediatric studies on stool CMV real-time PCR in CMV-GI disease have been carried out. Here, we evaluate the value of stool CMV real-time PCR in detecting CMV-GI disease among immunocompromised children...
May 15, 2017: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28492419/seroprevalence-of-antibodies-and-antigens-against-hepatitis-a-e-viruses-in-refugees-and-asylum-seekers-in-germany-in-2015
#7
Alexandra Jablonka, Philipp Solbach, Michael Wöbse, Michael P Manns, Reinhold E Schmidt, Heiner Wedemeyer, Markus Cornberg, Georg M N Behrens, Svenja Hardtke
BACKGROUND: Migration because of miscellaneous political crises in countries in the Middle East and Africa is a global challenge for whole Europe from an economic, social, and public health view. There is an urgent need to generate comprehensive, evidence-based data to expedite further screening and vaccination strategies. METHODS: A total of 604 individuals ranging in age from 2 to 68 years who enrolled at a single reception center were tested for the prevalence of serologic markers for hepatitis virus types A, B, C, D, and E (HAV, HBV, HCV, HDV, HEV), respectively...
May 10, 2017: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28471833/acoustic-radiation-force-impulse-in-the-diagnosis-of-liver-fibrosis-in-patients-with-chronic-hepatitis-b
#8
Rui Huang, Juan Xia, Yong Liu, Zhaoping Zhang, Chao Wu
No abstract text is available yet for this article.
May 3, 2017: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28471832/rising-relapse-rate-in-hepatitis-c-virus-type-3a-infected-patients-against-sofosbuvir-and-ribavirin-combination-therapy-a-pakistani-experience
#9
Braira Wahid, Komal Saleem, Amjad Ali, Shazia Rafique, Muhammad Idrees
No abstract text is available yet for this article.
May 3, 2017: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28471831/response-to-improvement-of-sleep-architecture-parameters-in-cirrhotic-patients-with-recurrent-hepatic-encephalopathy-with-the-use-of-rifaximin-hepatic-encephalopathy-in-association-with-zolpidem
#10
Ofir N Nevo, Allen D Brinker, Ida-Lina Diak, Cindy M Kortepeter
No abstract text is available yet for this article.
May 3, 2017: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28471830/impact-of-gastroesophageal-reflux-disease-symptoms-on-the-quality-of-life-in-pregnant-women-a-prospective-study
#11
Sara Fill Malfertheiner, Birgit Seelbach-Göbel, Serban-Dan Costa, Wolfgang Ernst, Edith Reuschel, Florian Zeman, Peter Malfertheiner, Maximilian V Malfertheiner
OBJECTIVE: Pregnant women often suffer from gastroesophageal reflux disease (GERD). GERD symptoms are known to influence the quality of life; however, there is a lack of data in pregnant women. The aim of this study was to establish the impact of GERD symptoms on health-related quality of life (HRQOL) during pregnancy. PARTICIPANTS AND METHODS: A prospective longitudinal cohort study to investigate the impact of GERD symptoms on the HRQOL was carried out in 510 pregnant women and 330 nonpregnant women as controls...
May 3, 2017: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28471829/epidemiology-of-pancreatic-cancer-in-france-descriptive-study-from-the-french-national-hospital-database
#12
Frédérique Maire, Jean-Olivier Cibot, Catherine Compagne, Olivia Hentic, Pascal Hammel, Nelly Muller, Philippe Ponsot, Philippe Levy, Philippe Ruszniewski
INTRODUCTION: Although indirect evidence suggests that the incidence of pancreatic adenocarcinoma has increased in the last decade, few data are available in European countries. The aim of the present study was to update the epidemiology of pancreatic cancer in France in 2014 from the French national hospital database (Programme de Médicalisation des Systèmes d'Information). PATIENTS AND METHODS: All patients hospitalized for pancreatic cancer in France in 2014 in public or private institutions were included...
May 3, 2017: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28471828/nonalcoholic-fatty-liver-disease-can-be-predicted-by-retinal-vascular-changes-in-patients-with-obesity-without-hypertension-or-diabetes
#13
Maria E Romero-Ibarguengoitia, Arturo Herrera-Rosas, Alfredo A Domínguez-Mota, Jinny T Camas-Benitez, María F Serratos-Canales, Mireya León-Hernández, Antonio González-Chávez, Eduardo López-Ortiz, Srinivas Mummidi, Ranvidranth Duggirala, Juan C López-Alvarenga
OBJECTIVE: To evaluate the utility of predicting nonalcoholic fatty liver disease (NAFLD) and obesity by retinal vascular changes (RVC) found in fundoscopy and to determine whether this is related to a low-grade inflammatory process. METHODS: We carried out a cross-sectional analysis that included 152 (ages 18-45 years) patients divided into four groups: NAFLD and BMI less than 25, absence of NAFLD and BMI less than 25, NAFLD and BMI more than 30, and absence of NAFLD and BMI more than 30...
May 3, 2017: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28471827/management-of-different-types-of-gastric-varices-with-band-ligation-a-3-year-experience
#14
Waseem M Seleem, Amr S Hanafy
BACKGROUND AND AIM: Gastric varices (GVs) occur with an incidence of 20% in patients with portal hypertension. The aim of this study was to evaluate the efficacy of endoscopic band ligation (BL) as an option in the management of small-to-moderate nonbleeding GVs in cirrhotic patients. PATIENTS AND METHODS: A total of 50 patients (GOV2; n=6, IGV1; n=34, IGV2; n=10) with nonbleeding small-to-moderate-sized GVs without local risk signs of bleeding, such as large size, red-colored elevated areas or red wales, and systemic factors of bleeding risk such as an international normalized ratio of at least 2 and a platelet count of 80 000/µl or less were subjected to endoscopic BL...
May 3, 2017: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28471826/chronic-comorbidities-associated-with-inflammatory-bowel-disease-prevalence-and-impact-on-healthcare-costs-in-switzerland
#15
Caroline Bähler, Alain M Schoepfer, Stephan R Vavricka, Beat Brüngger, Oliver Reich
OBJECTIVE: Inflammatory bowel disease (IBD) was shown to be associated with a variety of chronic comorbidities. We aimed to evaluate the frequency of 21 chronic conditions and compared frequencies in IBD and non-IBD populations. Further, healthcare costs of those (additional) chronic conditions were calculated. PATIENTS AND METHODS: A total of 4791 IBD patients, who were insured at Helsana Insurance Group in 2014, were compared with 1 114 638 individuals without IBD...
May 3, 2017: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28471825/literature-review-impacts-of-socioeconomic-status-on-the-risk-of-inflammatory-bowel-disease-and-its-outcomes
#16
Richard A Wardle, Andrew J Wardle, Creana Charadva, Subrata Ghosh, Gordon W Moran
The relationship between socioeconomic status (SES) and inflammatory bowel disease (IBD) is controversial. To date, research has focused on effects on incidence and prevalence, disease management and clinical outcomes; however, conclusions remain uncertain. This review examines current evidence, identifies what remains to be understood and explores the practical implications this has for today. A structured literature search in Ovid, Medline, the Cochrane library, Google Scholar and clinicaltrials.gov was performed using defined key words, including all articles up until 5 October 2016 assessing SES as a primary or secondary outcome measure...
May 3, 2017: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28471824/early-detection-of-sporadic-pancreatic-cancer-time-for-change
#17
Přemysl Frič, Aleksi Šedo, Jan Škrha, Petr Bušek, Martin Laclav, Pavel Škrha, Miroslav Zavoral
Sporadic pancreatic cancer amounts to ∼90% of all pancreatic cancers. It is a gloomy, depressive disease: the formula describes well the behavior of many SPC patients, and the most recalcitrant malignancy, with a very low 5-year survival (3-6%). At present, diagnostic methods are commonly applied, as used half a century ago, after the appearance of local and systemic symptoms (abdominal and back pain, cholestasis, painless jaundice, fatigue, anorexia, weight loss, anemia, peripheral phlebitis, and cachexia)...
May 3, 2017: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28471823/the-effects-of-diet-and-lifestyle-interventions-on-insulin-resistance-in-patients-with-nonalcoholic-fatty-liver-disease-a-systematic-review
#18
Tonya Paris, Elena S George, Stuart K Roberts, Audrey C Tierney
Nonalcoholic fatty liver disease (NAFLD) results from excessive fat accumulation in the liver in the absence of excessive alcohol consumption. Insulin resistance (IR) is proposed to be an underlying pathogenic factor in the development and progression of disease. There are currently no proven pharmacotherapies and weight loss is the only prescribed treatment despite a lack of evidence to support a specific diet or lifestyle therapy. The aim of this review is to evaluate the efficacy of dietary lifestyle interventions on IR measured by Homeostasis model assessment in patients with NAFLD...
May 3, 2017: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28471822/assessment-of-liver-fibrosis-with-acoustic-radiation-force-impulse-imaging-versus-liver-histology-in-patients-with-chronic-hepatitis-c-a-pilot-study
#19
Mohamed A S Kohla, Mohamed Abbasy, Mai Abozeid, Osama El-Abd, Sameera Ezzat, Samah Kohla, Mohamed Abdel-Rahman
BACKGROUND: Acoustic radiation force impulse imaging (ARFI) involves the mechanical excitation of tissues using short-duration acoustic pulses to generate localized displacements in tissue. The displacements results in shear-wave propagation, tracked by ultrasonography (US) correlation-based methods and recorded in meters per seconds. AIM: To compare (ARFI) integrated into a conventional US with the standard histological examination of liver biopsy specimens for the assessment of liver fibrosis...
May 3, 2017: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28471821/diabetic-status-and-grade-of-nonalcoholic-fatty-liver-disease-are-associated-with-lower-baroreceptor-sensitivity-in-patients-with-nonalcoholic-fatty-liver-disease
#20
Akanksha Singh, Mavidi S Kumar, Ashok K Jaryal, Piyush Ranjan, Kishore K Deepak, Sanjay Sharma, Ramakrishnan Lakshmy, Ravindra M Pandey, Naval K Vikram
OBJECTIVES: Baroreceptor sensitivity (BRS), a functional consequence of vascular stiffness, may be affected by the presence of diabetes mellitus (DM) and nonalcoholic fatty liver disease (NAFLD). The present study was designed to assess the effect of diabetic status and NAFLD grade on the BRS in patients with NAFLD. METHODS: Seventy-five individuals (25 NAFLD without DM, 25 NAFLD with DM and 25 controls) were recruited for the study who underwent anthropometric and body composition analysis along with estimation of plasma glucose, serum insulin and serum lipids...
May 3, 2017: European Journal of Gastroenterology & Hepatology
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