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European Journal of Gastroenterology & Hepatology

Dina Attia, Katja Deterding, Janet Cornberg, Michael J Gebel, Markus Cornberg, Michael P Manns, Heiner Wedemeyer, Andrej Potthoff
BACKGROUND: Direct-acting antivirals (DAAs) lead to a high rate of sustained virologic response (SVR) in chronic hepatitis C infection. The aim was to evaluate liver stiffness kinetics, using acoustic radiation force impulse (ARFI) imaging elastography, during and after DAAs in patients who had reached SVR. PATIENTS AND METHODS: A total of 275 consecutive chronic hepatitis C virus-infected patients were included in this longitudinal prospective single-centre study...
September 19, 2018: European Journal of Gastroenterology & Hepatology
Hala H Shehata, Asem A Elfert, Amany A Abdin, Samah M Soliman, Reham A Elkhouly, Nehad I Hawash, Hanan H Soliman
BACKGROUND: Overt hepatic encephalopathy (HE) is a frequent complication of cirrhosis and one of the most debilitating manifestations that necessitates hospitalization. Although many treatment modalities are being investigated, none of them are satisfactory. So, newer treatment modalities have to be tried. OBJECTIVE: To evaluate the safety and efficacy of polyethylene glycol (PEG) versus lactulose in the management of HE. PATIENTS AND METHODS: This clinical trial included 100 patients with post-hepatitis C cirrhosis who were admitted with HE...
September 18, 2018: European Journal of Gastroenterology & Hepatology
Muhammad T Farooqui, Muhammad Ali Khan, George Cholankeril, Zubair Khan, Mubeen K Mohammed Abdul, Andrew A Li, Neha Shah, Lin Wu, Khwaja Haq, Shantanu Solanki, Donghee Kim, Aijaz Ahmed
BACKGROUND: An estimated 22 million adults use marijuana in the USA. The role of marijuana in the progression of hepatic fibrosis remains unclear. AIMS: We carried out a systematic review and meta-analysis to evaluate the impact of marijuana on prevalence and progression of hepatic fibrosis in chronic liver disease. PATIENTS AND METHODS: We searched several databases from inception through 10 November 2017 to identify studies evaluating the role of marijuana in chronic liver disease...
September 18, 2018: European Journal of Gastroenterology & Hepatology
Matteo Renzulli, Alfredo Clemente, Stefano Brocchi, Matteo Milandri, Vincenzo Lucidi, Ranka Vukotic, Salvatore Cappabianca, Rita Golfieri
The Liver Imaging Reporting and Data System (LI-RADS) is a widespread comprehensive system for standardising the reporting and data collection of liver imaging to standardise chronic liver disease evaluation. However, the LI-RADS, based on the identification of some categories of lesions by means of a conceptual and nonquantitative probability approach, has many limitations. In fact, recently, the European Association for the Study of the Liver Guidelines regarding the management of hepatocellular carcinoma did not accept the LI-RADS...
September 18, 2018: European Journal of Gastroenterology & Hepatology
David Martin, David Petermann, Sara Fontanella, Yan Pu, Nermin Halkic, Nicolas Demartines, Markus Schäfer
OBJECTIVES: Technical feasibility and safety of portal vein (PV) and superior mesenteric vein (SMV) resection during pancreaticoduodenectomy (PD) for cancer has been confirmed, but oncological benefits remain unclear. The present study aimed to explore the long-term outcomes of PD with PV/SMV resection and proven histologically invasion. PATIENTS AND METHODS: A total of 95 consecutive PD were performed between January 2008 and August 2013, and 29 patients underwent PV/SMV resection with histologically proven venous tumor infiltration...
September 14, 2018: European Journal of Gastroenterology & Hepatology
Julian Essmann, Carsten Keil, Olesya Unruh, Anita Otte, Michael P Manns, Oliver Bachmann
BACKGROUND: The value of therapeutic drug monitoring during azathioprine (AZA) therapy with respect to clinical outcomes has been convincingly demonstrated in recent meta-analyses. However, the association between AZA metabolites and the mucosal state in inflammatory bowel disease is largely unclear. AIMS: We investigated the association between AZA's active metabolite 6-thioguanine nucleotides (6-TGN) and fecal calprotectin (FC) as a well-validated surrogate marker of mucosal inflammation in patients with Crohn's disease (CD) on AZA monotherapy...
September 12, 2018: European Journal of Gastroenterology & Hepatology
Alvaro Garcia-Granero, Brenda G Argüelles, Carmen Muniesa Gallardo, Omar Carreño, Francisco Giner, Gianluca Pellino, Matteo Frasson
OBJECTIVES: Perforated jejunal diverticulitis (PJD) is rare, but it has high mortality rates. The role of nonsurgical management is debated. The aim of this study is to assess the outcomes of medical and surgical management of PJD. PATIENTS AND METHODS: A single-centre study on a series of emergency patients diagnosed with PJD between 2010 and 2016 was conducted. RESULTS: Eleven patients with PJD were treated (seven women). Nine out of 11 were diagnosed by a computed tomography scan, and two were diagnosed at laparotomy...
September 11, 2018: European Journal of Gastroenterology & Hepatology
Eun Suk Jung, Britt-Sabina Petersen, Gabriele Mayr, Jae Hee Cheon, Yunkoo Kang, Seok Joo Lee, Xiumei Che, Won Ho Kim, Seung Kim, Stefan Schreiber, Andre Franke, Hong Koh
OBJECTIVES: Inflammatory bowel diseases (IBDs) are chronic and multifactorial diseases resulting from a complex interaction of host genetic factors and environmental stimuli. Although many genome-wide association studies have identified host genetic factors associated with IBD, rare Mendelian forms of IBD have been reported in patients with very early onset forms. Therefore, this study aimed to identify genetic variants associated with infantile-onset IBD. PARTICIPANTS AND METHODS: We obtained genomic DNA from whole blood samples of a male patient with infantile-onset IBD and nonconsanguineous Korean parents...
September 7, 2018: European Journal of Gastroenterology & Hepatology
Ashraf O Abdelaziz, Mohamed M Nabil, Ahmed H Abdelmaksoud, Hend I Shousha, Mohamed B Hashem, Eman M Hassan, Ayman Salah, Dalia A Omran, Tamer M Elbaz
INTRODUCTION: Scarce reports have commented on hepatocellular carcinoma (HCC) behavior after direct-acting antivirals (DAAs). AIM: To analyze differences in tumor behavior between patients with hepatitis C virus (HCV)-induced HCC and were either treated or not using DAAs. PATIENTS AND METHODS: This case-control study includes patients with HCV-related HCC who received generic DAAs (group I) and all non-DAA treated patients with HCC who presented to our clinic during the same period (group II)...
September 7, 2018: European Journal of Gastroenterology & Hepatology
Mahmoud Mosli, Sultan Alfaer, Turki Almalaki, Abdulrahman Albeshry, Saja Aljehani, Bashaer Alshmrani, Zaineb Habib, Hani Jawa, Yousif Qari
BACKGROUND AND AIMS: Treatment of ulcerative colitis (UC) typically follows a step-up approach and targets colonic mucosal healing. Although mucosal healing reduces the risk of colectomy, whether or not early treatment of patients with 'high-risk' features using tumor necrosis factor (TNF) antagonists reduces the risk of colectomy is not clear. Accordingly, we aim to evaluate the effect of baseline treatment selection according to the risk profile on 5-year outcomes and identify predictors of poor outcomes...
September 7, 2018: European Journal of Gastroenterology & Hepatology
Stefania Chetcuti Zammit, Pierre Ellul, Giulia Girardin, Daniela Valpiani, Kári R Nielsen, Jóngerð Olsen, Adrian Goldis, Daniela Lazar, Olga Shonová, Marie Nováková, Shaji Sebastian, Emma Whitehead, Amalia Carmona, Jesus Martinez-Cadilla, Jens F Dahlerup, Adriana L H Kievit, Niels Thorsgaard, Konstantinos H Katsanos, Dimitrios K Christodoulou, Fernando Magro, Riina Salupere, Natalia Pedersen, Jens Kjeldsen, Katrine Carlsen, Kaimaklioti Ioannis, Daniel Bergemalm, Jonas Halfvarson, Dana Duricova, Martin Bortlik, Pekka Collin, Pia Oksanen, Gediminas Kiudelis, Limas Kupcinskas, Karen Kudsk, Vibeke Andersen, Colm O'Morain, Yvonne Bailey, Schwartz Doron, Odes Shmuel, Sven Almer, Naila Arebi, Ravi Misra, Silvija Čuković-Čavka, Marko Brinar, Pia Munkholm, Zsuzsanna Vegh, Johan Burisch
BACKGROUND: Serum vitamin D level is commonly low in patients with inflammatory bowel disease (IBD). Although there is a growing body of evidence that links low vitamin D level to certain aspects of IBD such as disease activity and quality of life, data on its prevalence and how it varies across disease phenotype, smoking status and treatment groups are still missing. MATERIALS AND METHODS: Patients diagnosed with IBD between 2010 and 2011 were recruited. Demographic data and serum vitamin D levels were collected...
September 7, 2018: European Journal of Gastroenterology & Hepatology
Sofie Coenen, Marie-Noëlle Schmickler, Daniëlle Staes, Frieda Wieme, Tony Swinnen, Xavier Dekeuleneer, Tineke van Hooland, Kris van den Cruys, Séverine Vermeire
OBJECTIVES: Inflammatory bowel diseases (IBD) are chronic gastrointestinal conditions mainly affecting young people. Disease symptoms often make it difficult to actively participate in the workplace. The aim of Activ84worK was to stimulate professional activity and reduce absenteeism by removing work-related stress factors and providing patients with more flexible working conditions. PATIENTS AND METHODS: Activ84worK was a collaboration between Abbvie, Mensura, Proximus, SD Worx, and University Hospitals Leuven (UZ Leuven) with the support of the patient association 'Crohn-en Colitis Ulcerosa Vereniging (CCV vzw)' in Flanders, Belgium...
September 5, 2018: European Journal of Gastroenterology & Hepatology
Paraskevas Gkolfakis, Georgios Tziatzios, Antonio Facciorusso, Nicola Muscatiello, Konstantinos Triantafyllou
INTRODUCTION: A variety of add-on devices and new-generation endoscopes have the potential to detect lesions 'hidden' behind colonic folds. We measured the effect of these new modalities on colonoscopy's lesions miss rates by a meta-analysis of data from individual studies. MATERIALS AND METHODS: We performed literature searches in Medline and Cochrane Library for back-to-back randomized-controlled trials evaluating colonoscope add-on devices and new endoscopes in terms of lesions miss rates...
September 4, 2018: European Journal of Gastroenterology & Hepatology
Kryssia I Rodriguez-Castro, Alessandro Vitale, Mariangela Fadin, Sarah Shalaby, Patrizia Zerbinati, Maria Teresa Sartori, Stefano Landi, Irene Pettinari, Fabio Piscaglia, Guohong Han, Patrizia Burra, Paolo Simioni, Marco Senzolo
BACKGROUND AND OBJECTIVE: Portal vein thrombosis (PVT) is a common complication in cirrhosis, and when complete, it increases morbidity and mortality in liver transplant candidates. The aim of the study was to assess the hemostatic status, as well as clinical characteristics of thrombus and patients, as predictors of therapeutic efficacy of anticoagulation for the treatment of PVT in cirrhotics. PATIENTS AND METHODS: Patients with cirrhosis consecutively treated for PVT with enoxaparin were enrolled...
September 4, 2018: European Journal of Gastroenterology & Hepatology
Evangelos Stournaras, Georgios Neokosmidis, Dimitrios Stogiannou, Andreas Protopapas, Konstantinos Tziomalos
Hepatocellular carcinoma (HCC) is a major complication of chronic hepatitis B (CHB) and chronic hepatitis C (CHC). Accumulating data suggest that antiviral treatment in both CHB and CHC reduces the incidence of HCC. Evidence is more consistent for interferon-based treatment in both CHB and CHC and for lamivudine in patients with CHB. However, more limited data suggest that other nucleos(t)ide analogues might also reduce the risk of HCC. In contrast, conflicting data have been reported on the effects of direct-acting antivirals on the incidence of HCC...
September 1, 2018: European Journal of Gastroenterology & Hepatology
Xiaobo Cai, Haiyun Zhang, Shenzheng Luo, Li Baiwen, Jing Ma, Lungen Lu, Xinjian Wan
BACKGROUND AND AIM: Endoscopic biliary drainage is difficult in patients with biliary obstruction combined with gastric outlet stricture (GOS). Endoscopic ultrasound is useful for such patients, but needs advanced technique and sophisticated equipment. This study aimed to evaluate the efficacy and safety of conventional endoscopic retrograde cholangiopancreatography (ERCP) in patients with GOS and biliary obstruction without the assistance of endoscopic ultrasound. PATIENTS AND METHODS: Seventy-four patients with GOS proximal to the ampulla and biliary obstruction, including 27 with benign GOS and 47 with malignant GOS, were retrospectively enrolled...
September 1, 2018: European Journal of Gastroenterology & Hepatology
Aiko Fukui, Naoto Kawabe, Senju Hashimoto, Hiroyuki Kamei, Kentaro Yoshioka
OBJECTIVE: The aim was to assess the relationship between muscle mass depletion and chronic hepatitis C virus (HCV) infection. PATIENTS AND METHODS: We retrospectively evaluated abdominal computed tomography data for 611 patients. The participants included 302 patients with HCV infection and 309 patients with gallstones (as a control). The skeletal muscle mass at the level of the third lumber vertebra (L3) was measured from the computed tomography images and normalized for height to calculate the L3 skeletal muscle index (L3-SMI, cm/m)...
September 1, 2018: European Journal of Gastroenterology & Hepatology
Grace H Tang, Rachel Hart, Michelle Sholzberg, Christine Brezden-Masley
BACKGROUND: Gastric cancer is highly prevalent amongst men and women. Previous studies have described the high prevalence of iron deficiency anemia (IDA) in gastrointestinal cancer patients, but few have focused on the gastric cancer population. We aimed to determine the point prevalence of patients with gastric cancer who developed IDA and chemotherapy-induced anemia, and to identify types and frequencies of IDA therapies. PATIENTS AND METHODS: A retrospective review was carried out for 126 gastric cancer patients from 2006 to 2016 at St Michael's Hospital, Toronto, Canada...
September 1, 2018: European Journal of Gastroenterology & Hepatology
Hemant Goyal, M Rubayat Rahman, Abhilash Perisetti, Nihar Shah, Rajiv Chhabra
The recent legalization of recreational marijuana use in some parts of the world, the discovery of new indications for the clinical application of cannabis, and the acceptance of the use of cannabis in practice has been paralleled by extensive research on the active components of cannabis and the endocannabinoid system within the human body. In this review, we evaluate the available evidence on cannabis and its constituents and the application of this evidence in clinical practice, focusing particularly on the liver and liver diseases...
August 30, 2018: European Journal of Gastroenterology & Hepatology
Edith Lahner, Marilia Carabotti, Gianluca Esposito, Cesare Hassan, Angelo Zullo, Bruno Annibale
OBJECTIVES: The frequency of metaplastic atrophic gastritis in noninvestigated dyspepsia and its associated symptoms pattern are not known. This study aimed to assess the occurrence and clinical predictors of metaplastic atrophic gastritis in a consecutive endoscopic population presenting with upper gastrointestinal symptoms. PATIENTS AND METHODS: A post-hoc cross-sectional study was carried out on endoscopic-histological data from 668 patients (64% women, age: 58 years) with upper gastrointestinal symptoms obtained during a multicenter study...
August 29, 2018: European Journal of Gastroenterology & Hepatology
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