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European Journal of Gastroenterology & Hepatology

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https://www.readbyqxmd.com/read/28639970/hyperuricemia-is-associated-with-nonalcoholic-fatty-liver-disease-activity-score-in-patients-with-nonalcoholic-fatty-liver-disease-a-systematic-review-and-meta-analysis
#1
Veeravich Jaruvongvanich, Wasin Ahuja, Kamonkiat Wirunsawanya, Karn Wijarnpreecha, Patompong Ungprasert
BACKGROUND: Hyperuricemia is a significant risk factor for nonalcoholic fatty liver disease (NAFLD). It may also have an impact on the histologic severity of NAFLD. However, data on this association are limited. We conducted this meta-analysis to investigate the relationship of serum uric acid with liver histologic severity as determined by NAFLD activity score (NAS) in patients with NAFLD. PATIENTS AND METHODS: MEDLINE and EMBASE databases were searched through August 2016 for studies that investigated the association between hyperuricemia and NAS among patients with biopsy-proven NAFLD...
June 21, 2017: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28639969/the-prevalence-of-irritable-bowel-syndrome-type-symptoms-in-inflammatory-bowel-disease-patients-in-remission
#2
Daniël R Hoekman, Judith Zeevenhooven, Geert R D'Haens, Marc A Benninga
OBJECTIVE: Symptoms of irritable bowel syndrome (IBS) are common in inflammatory bowel disease (IBD) and are believed to reflect ongoing inflammation. Consequently, a low prevalence of IBS-type symptoms in IBD patients with normal inflammatory markers is expected. We aimed to investigate the prevalence of IBS-type symptoms in IBD patients in biochemical remission (evidenced by low fecal calprotectin levels) and the relationship of these symptoms with fecal calprotectin levels. PATIENTS AND METHODS: In this observational, cross-sectional study, we included all adults with a history of IBD who had calprotectin levels less than 200 µg/g during routine follow-up between August 2014 and May 2015 at our hospital...
June 21, 2017: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28628497/predicting-short-term-and-long-term-mortality-of-hospitalized-portuguese-patients-with-alcoholic-hepatitis
#3
Samuel R Fernandes, Pedro Marques da Costa, Sofia Vítor, Joana R Carvalho, Patrícia Santos, Carlos M Moura, Helena Cortez-Pinto, Fernando Ramalho, José Velosa
BACKGROUND: Alcohol abuse can result in a spectrum of liver injury that ranges from mild fatty infiltration to alcoholic hepatitis (AH), cirrhosis, and hepatocellular carcinoma. The present study aimed to evaluate current scoring systems in predicting short-term and long-term mortality because of AH. PATIENTS AND METHODS: Records of 170 consecutive patients with AH admitted to a tertiary center between January 2005 and October 2015 were reviewed. Clinical and biochemical parameters were retrieved for the assessment of AH scores for the day of admission (D1) and for the seventh day of hospitalization (D7)...
June 16, 2017: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28628496/proton-pump-inhibitor-and-selective-serotonin-reuptake-inhibitor-therapy-for-the-management-of-noncardiac-chest-pain
#4
Nikos Viazis, Konstantina Katopodi, George Karamanolis, Konstantinos Denaxas, Lazaros Varytimiadis, Michail Galanopoulos, Emmanouela Tsoukali, Dimitirs Kamberoglou, Angeliki Christidou, Dimitrios G Karamanolis, George Papatheodoridis, Gerasimos J Mantzaris
INTRODUCTION: Although gastroesophageal reflux disease is the main cause of noncardiac chest pain (NCCP), proton pump inhibitors (PPIs) benefit a minority of patients. Our prospective study evaluated the effect of PPI and selective serotonin reuptake inhibitors on the different subtypes of NCCP characterized by impedance-pH monitoring. METHODS: All NCCP patients underwent impedance-pH monitoring and on the basis of the results, those with abnormal distal esophageal acid exposure received PPIs twice daily (group A), those with a positive symptom index for chest pain received citalopram 20 mg and PPI once daily (group B), and those with a negative symptom index for chest pain received citalopram 20 mg once daily (group C)...
June 16, 2017: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28614081/spontaneous-fungal-peritonitis-a-rare-but-severe-complication-of-liver-cirrhosis
#5
Marta Gravito-Soares, Elisa Gravito-Soares, Sandra Lopes, Graça Ribeiro, Pedro Figueiredo
INTRODUCTION AND AIM: Spontaneous bacterial peritonitis is the most common infectious complication in cirrhosis. Spontaneous fungal peritonitis is rare and remains unknown. In this work, spontaneous fungal peritonitis as well as risk factors and prognosis are characterized. PATIENTS AND METHODS: A retrospective case-control study of 253 consecutive admissions by peritonitis in cirrhotic patients was carried out between 2006 and 2015. Comparison of patients with spontaneous fungal peritonitis (cases) and spontaneous bacterial peritonitis with positive microbiologic ascitic fluid culture (controls) was performed...
June 13, 2017: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28570343/controlled-attenuation-parameter-for-diagnosing-steatosis-in-bariatric-surgery-candidates-with-suspected-nonalcoholic-fatty-liver-disease
#6
Sylvie Naveau, Cosmin S Voican, Amandine Lebrun, Martin Gaillard, Karima Lamouri, Micheline Njiké-Nakseu, Rodi Courie, Hadrien Tranchart, Axel Balian, Sophie Prévot, Ibrahim Dagher, Gabriel Perlemuter
INTRODUCTION: Steatosis in patients with nonalcoholic fatty liver disease (NAFLD) is often benign, but may progress to fibrosis. The accurate diagnosis of hepatic steatosis is therefore important for clinical decision-making and prognostic assessments. The controlled attenuation parameter (CAP), a noninvasive measurement obtained with Fibro-Scan, has been developed for liver steatosis assessment. CAP performs poorly in patients with high BMI. The XL probe was initially developed for measuring liver stiffness in overweight patients...
May 31, 2017: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28562395/differential-significance-of-early-surgical-complications-for-acute-and-long-term-recurrence-free-survival-following-surgical-resection-of-hepatocellular-carcinoma-do-comorbidities-play-a-role
#7
Andrej Khandoga, Moritz Drefs, Markus Schoenberg, Tobias Schiergens, Katharina Frenes, Mark Op den Winkel, Christoph Trumm, Martin K Angele, Markus Guba, Jens Werner, Markus Rentsch
BACKGROUND: Postoperative complications of Clavien-Dindo grade 3 or more are of prognostic significance in patients who undergo liver resection for hepatocellular carcinoma (HCC). However, perioperative mortality and patient comorbidities represent relevant factors that interfere with postoperative long-term survival. To clarify this, a retrospective single-center study was carried out. PATIENTS AND METHODS: Patient data were prospectively collected in a continuously updated liver resection database...
May 30, 2017: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28562394/diagnostic-accuracy-of-contrast-enhanced-ultrasound-for-the-differential-diagnosis-of-hepatocellular-carcinoma-esculap-versus-ceus-li-rads
#8
Barbara Schellhaas, Ruediger S Görtz, Lukas Pfeifer, Christian Kielisch, Markus F Neurath, Deike Strobel
OBJECTIVE: A comparison is made of two contrast-enhanced ultrasound (CEUS) algorithms for the diagnosis of hepatocellular carcinoma (HCC) in high-risk patients: Erlanger Synopsis of Contrast-enhanced Ultrasound for Liver lesion Assessment in Patients at Risk (ESCULAP) and American College of Radiology Contrast-Enhanced Ultrasound-Liver Imaging Reporting and Data System (ACR-CEUS-LI-RADSv.2016). PATIENTS AND METHODS: Focal liver lesions in 100 high-risk patients were assessed using both CEUS algorithms (ESCULAP and CEUS-LI-RADSv...
May 30, 2017: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28562393/association-between-lower-air-pressure-and-the-onset-of-ischemic-colitis-a-case-control-study
#9
Takefumi Kimura, Akihiro Shinji, Naoki Tanaka, Masayoshi Koinuma, Maki Yamaura, Tadanobu Nagaya, Satoru Joshita, Michiharu Komatsu, Takeji Umemura, Akira Horiuchi, Shuichi Wada, Eiji Tanaka
OBJECTIVE: Ischemic colitis (IC) often affects the elderly. Proarteriosclerotic factors, such as hypertension and smoking, and cardiovascular disease are considered major contributors to IC. Although a possible link between certain cerebrocardiovascular disorders and meteorological phenomena has been reported, the relationship between IC onset and weather changes remains uninvestigated. This study examined whether specific meteorological factors were associated with the occurrence of IC...
May 30, 2017: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28542115/exposure-to-oral-contraceptives-increases-the-risk-for-development-of-inflammatory-bowel-disease-a-meta-analysis-of-case-controlled-and-cohort-studies
#10
Ronald Ortizo, Stephanie Y Lee, Emily T Nguyen, Mohammad Mazen Jamal, Matthew M Bechtold, Douglas L Nguyen
BACKGROUND: The oral contraceptive pill (OCP) is a widely used method of contraception. There have been conflicting studies linking the use of OCPs to the development of inflammatory bowel disease (IBD). The intent of this meta-analysis is to better define the association between OCP exposure and the risk for development of IBD. METHODS: A thorough search of multiple databases, including Scopus, Cochrane, MEDLINE/PubMed, and CINAHL, and abstracts from major gastroenterology meetings was performed (October, 2016)...
May 24, 2017: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28542114/predictors-of-pouchitis-after-ileal-pouch-anal-anastomosis-in-pediatric-onset-ulcerative-colitis
#11
Firas Rinawi, Amit Assa, Rami Eliakim, Yael Mozer Glassberg, Vered Nachmias Friedler, Yaron Niv, Yoram Rosenbach, Ari Silbermintz, Noam Zevit, Raanan Shamir
OBJECTIVES: Few studies have reported on the incidence and risk factors for pouchitis following colectomy and ileal pouch-anal anastomosis (IPAA) in patients with pediatric-onset ulcerative colitis (UC). We aimed to determine clinical predictors for the development of pouchitis following IPAA in this population. PATIENTS AND METHODS: We performed a retrospective chart review of all pediatric UC cases that were diagnosed at the Schneider Children's Medical Center of Israel between 1981 and 2013 and who underwent colectomy during disease course...
May 24, 2017: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28542113/increased-arterial-stiffness-in-nonalcoholic-fatty-liver-disease-a-systematic-review-and-meta-analysis
#12
Veeravich Jaruvongvanich, Jirat Chenbhanich, Anawin Sanguankeo, Pattara Rattanawong, Karn Wijarnpreecha, Sikarin Upala
BACKGROUND: Arterial function is a marker of early atherosclerotic changes and cardiovascular disease. Several studies have suggested the possible association between nonalcoholic fatty liver disease (NAFLD) and increased arterial stiffness. Thus, we conducted a systematic review and meta-analysis to better characterize this association. PATIENTS AND METHODS: A comprehensive search of the databases of the MEDLINE and EMBASE was carried out from inception through September 2016...
May 24, 2017: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28538269/novel-therapies-and-potential-therapeutic-targets-in-the-management-of-chronic-hepatitis-b
#13
Joao M Serigado, Manhal Izzy, Harmit Kalia
Chronic hepatitis B is a persistent and progressive inflammatory liver disease caused by infection with the hepatitis B virus (HBV). More than 240 million individuals are infected with HBV worldwide and hepatitis B accounts for an estimated 650 000 deaths annually. Approximately up to 30% of chronically infected patients will develop complications of HBV infection including, but not limited to, liver cirrhosis, end-stage liver disease, and hepatocellular carcinoma. Currently approved therapies have improved clinical outcomes, but have a considerable side-effect profile, elevated cost, and a finite course of treatment...
May 19, 2017: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28538268/etiological-factors-of-chronic-hepatitis-in-italy-a-2014-national-survey
#14
Tommaso Stroffolini, Evangelista Sagnelli, Piero L Almasio, Angelo Andriulli, Antonina Smedile, Mario Pirisi, Caterina Sagnelli, Maurizio Russello, Nicola Coppola, Massimo de Luca, Mariantonietta Pisaturo, Floriano Rosina, Giovanni B Gaeta
BACKGROUND: The last Italian prevalence survey on chronic hepatitis (CH) conducted in 2001 showed that the hepatitis C virus (HCV) was the main agent associated with CH. AIM: The aim of this study was to evaluate epidemiological changes in CH occurring after 13 years. PATIENTS AND METHODS: Enrollment of 1392 CH consecutive patients referred to 16 Italian liver units in 2014 scattered all over the country (four in the North, four in the Center, four in the South, and four in the Islands) was performed...
May 19, 2017: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28538267/cirrhosis-has-no-impact-on-therapeutic-responses-of-entecavir-for-chronic-hepatitis-b
#15
Pin-Chao Wang, Tao-Yang Wei, Tai-Chung Tseng, Hans Hsienhong Lin, Chia-Chi Wang
OBJECTIVE: As the efficacy of a direct antiviral agent is reduced in cirrhotic chronic hepatitis C patients, prolonged duration of treatment or addition of ribavirin is recommended to improve the rates of sustained virological response. However, the impact of cirrhosis on the efficacy of antiviral treatment for chronic hepatitis B (CHB) remained unclear. PATIENTS AND METHODS: This retrospective cohort study screened entecavir (ETV)-treated CHB patients in Taipei Tzu Chi Hospital from January 2007 till October 2014...
May 19, 2017: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28520575/predictors-of-bile-tree-pathology-in-patients-presenting-with-gallbladder-disease
#16
Mahmoud A Rahal, Mohammad O Rammal, Walid Karaoui, Ali Hallal, Hani Tamim, Yasser Shaib
BACKGROUND: Patients with gallstone disease can present with elevated liver function tests (LFTs). It is often challenging to differentiate those with a common bile duct (CBD) stone from those without a CBD stone on the basis of the LFTs levels. In this study, we aim to evaluate the predictors of a CBD stones among patients presenting with symptomatic gallbladder disease and elevated LFTs. PATIENTS AND METHODS: We retrospectively examined all patients who had undergone a cholecystectomy between January 2010 and December 2015...
May 17, 2017: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28520574/orthotopic-liver-transplantation-changes-the-course-of-gastric-antral-vascular-ectasia-a-case-series-from-a-transplant-center
#17
Chaitanya Allamneni, Basem Alkurdi, Rehan Naseemuddin, Brendan M McGuire, Mohamed G Shoreibah, Devin E Eckhoff, Shajan Peter
BACKGROUND AND AIM: Gastric antral vascular ectasia (GAVE) is an important cause of upper gastrointestinal bleeding and anemia in patients with cirrhosis. The aim of our study was to evaluate the effect of orthotopic liver transplantation (OLT) on GAVE and associated anemia. PATIENTS AND METHODS: We performed a chart review and identified all cirrhotic patients with GAVE who underwent OLT at the University Of Alabama at Birmingham between 2005 and 2013. Population's demographics, etiology of cirrhosis, comorbidities, presentation and treatment modalities of GAVE, endoscopic and histopathologic reports, hemoglobin values before and after transplant, and immunosuppressive regimens were collected...
May 17, 2017: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28509677/stool-cytomegalovirus-polymerase-chain-reaction-for-the-diagnosis-of-cytomegalovirus-related-gastrointestinal-disease
#18
Noparat Prachasitthisak, Pornthep Tanpowpong, Chatmanee Lertudomphonwanit, Suporn Treepongkaruna, Sophida Boonsathorn, Napat Angkathunyakul, Pattana Sornmayura, Wasun Chantratita
OBJECTIVES: The diagnosis of cytomegalovirus-related gastrointestinal disease (CMV-GI disease) still requires histopathology, but biopsy is considered invasive. Stool CMV PCR has been reported in adults as an alternative method to diagnose this condition; hence, the results between studies are discrepant. Moreover, no pediatric studies on stool CMV real-time PCR in CMV-GI disease have been carried out. Here, we evaluate the value of stool CMV real-time PCR in detecting CMV-GI disease among immunocompromised children...
May 15, 2017: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28492419/seroprevalence-of-antibodies-and-antigens-against-hepatitis-a-e-viruses-in-refugees-and-asylum-seekers-in-germany-in-2015
#19
Alexandra Jablonka, Philipp Solbach, Michael Wöbse, Michael P Manns, Reinhold E Schmidt, Heiner Wedemeyer, Markus Cornberg, Georg M N Behrens, Svenja Hardtke
BACKGROUND: Migration because of miscellaneous political crises in countries in the Middle East and Africa is a global challenge for whole Europe from an economic, social, and public health view. There is an urgent need to generate comprehensive, evidence-based data to expedite further screening and vaccination strategies. METHODS: A total of 604 individuals ranging in age from 2 to 68 years who enrolled at a single reception center were tested for the prevalence of serologic markers for hepatitis virus types A, B, C, D, and E (HAV, HBV, HCV, HDV, HEV), respectively...
May 10, 2017: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28471833/acoustic-radiation-force-impulse-in-the-diagnosis-of-liver-fibrosis-in-patients-with-chronic-hepatitis-b
#20
Rui Huang, Juan Xia, Yong Liu, Zhaoping Zhang, Chao Wu
No abstract text is available yet for this article.
May 3, 2017: European Journal of Gastroenterology & Hepatology
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