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European Journal of Gastroenterology & Hepatology

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https://www.readbyqxmd.com/read/29465473/characteristics-of-patients-with-hepatitis-c-virus-related-chronic-liver-diseases-just-before-the-era-of-oral-direct-acting-antiviral-therapy-in-italy
#1
Evangelista Sagnelli, Tommaso Stroffolini, Caterina Sagnelli, Bruno Cacopardo, Angelo Andriulli, Sergio Babudieri, Nicola Coppola, Giovanni B Gaeta, Piero L Almasio
BACKGROUND: In 2017, oral direct-acting antiviral (DAA) therapy for chronic hepatitis C virus (HCV) infection became available free of charge for all HCV-RNA-positive patients, irrespective of their fibrosis stage. AIM: The aim of this study was to evaluate the characteristics of HCV-related chronic liver disease (CLD) in Italy just before the introduction of DAA therapy. PATIENTS AND METHODS: Patients with CLD were enrolled in two national surveys conducted in 2001 and in 2014...
February 20, 2018: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29465472/a-new-prognostic-score-can-predict-survival-after-hepatocellular-carcinoma-treatment-in-a-cohort-of-1302-egyptian-hepatocellular-carcinoma-patients
#2
Ashraf O Abdelaziz, Hend I Shousha, Ahmed H Abdelmaksoud, Yasmin Saad, Tamer M Elbaz, Zeinab A Soliman, Ayman Salah, Rania Lithy, Mona Ahmed, Mohamed M Nabil
INTRODUCTION: Survival of hepatocellular carcinoma (HCC) differs between regions and countries according to the different underlying factors and the degree of standard of care that enables early diagnosis and management. Our aim was to identify the most potent predictive factors of survival in Egyptian HCC patients receiving curative or palliative treatments. PATIENTS AND METHODS: This retrospective study included 1302 HCC patients attending the HCC multidisciplinary clinic, Cairo University, between February 2009 and December 2016...
February 20, 2018: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29462029/patient-tolerance-and-acceptance-of-different-colonic-imaging-modalities-an-observational-cohort-study
#3
Hannah Ojidu, Hansa Palmer, Jakub Lewandowski, James Hampton, Tony Blakeborough, Owen Epstein, Mark E McAlindon
BACKGROUND: Less invasive alternatives to optical colonoscopy (OC) may improve patient compliance with investigation, but study of patient preference is limited. OBJECTIVES: The aims of this study were to determine patient tolerance and acceptability of OC, computed tomography colonography (CTC) and colon capsule endoscopy (CCE) and also to determine the choice of investigation made by fully informed members of the lay public. PATIENTS AND METHODS: Patients assigned a Gloucester Comfort Score (GCS, 1-5; as did endoscopists), an overall test experience score (visual analogue scale, 0-10) and completed a 'Friends and Family Test' following OC, CTC or CCE...
February 16, 2018: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29462028/the-operative-risk-and-natural-history-after-the-diagnosis-of-ileal-penetrating-crohn-s-disease
#4
Peter Bossuyt, Celine Debeuckelaere, Marc Ferrante, Dirk Vanbeckevoort, Thomas Billiet, Albert Wolthuis, Gert van Assche, Andre D'Hoore, Séverine Vermeire
BACKGROUND AND PURPOSE: Crohn's disease (CD) is marked by transmural inflammation of the bowel wall leading to stricturing and/or penetrating complications in the majority of patients. The natural history and operative risk after the diagnosis of an ileal penetrating complication is understudied. The aim was to study the disease course and need for surgery in patients diagnosed with a penetrating ileal CD complication and to assess the risk factors associated with worse postoperative outcome...
February 16, 2018: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29462027/transjugular-intrahepatic-portosystemic-shunt-creation-for-cirrhotic-portal-hypertension-is-well-tolerated-among-patients-with-portal-vein-thrombosis
#5
Jonathan Merola, Brett E Fortune, Yanhong Deng, Maria Ciarleglio, Smbat Amirbekian, Noami Chaudhary, Alampady Shanbhogue, Rajasekhara Ayyagari, Manuel I Rodriguez-Davalos, Lewis Teperman, Hearns W Charles, Samuel H Sigal
BACKGROUND: Portal vein thrombosis (PVT) develops in cirrhotic patients because of stagnation of blood flow. Transjugular intrahepatic portosystemic shunt (TIPS) creates a low-resistance conduit that restores portal venous patency and blood flow. AIM: The effect of PVT on transplant-free survival in cirrhotic patients undergoing TIPS creation was evaluated. PATIENTS AND METHODS: A multicenter, retrospective cohort study of patients who underwent TIPS creation for cirrhotic portal hypertension was carried out...
February 16, 2018: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29462026/anticoagulant-therapy-for-venous-thromboembolism-in-patients-with-inflammatory-bowel-disease
#6
Jose L Lobo, Julia A Garcia-Fuertes, Javier Trujillo-Santos, Adel Merah, María Á Blanco-Molina, Ignacio Casado, Jana Hirmerova, Javier De Miguel, Estuardo Salgado, Manuel Monreal
BACKGROUND: There is lack of evidence to guide the type, intensity, and the duration of anticoagulation following venous thromboembolism (VTE) in patients with inflammatory bowel disease (IBD). PATIENTS AND METHODS: Registro Informatizado Enfermedad Trombo Embólica (RIETE) is an ongoing, multicenter, observational registry of consecutive patients with symptomatic, objectively confirmed, acute VTE. We used the RIETE database to compare the rate of VTE recurrences and major bleeding during the course of anticoagulation in noncancer patients with or without IBD...
February 16, 2018: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29462025/primary-biliary-cholangitis-is-more-severe-in-previous-hepatitis-b-virus-infection-patients
#7
Yingyu Zhang, Ying Shi, Ruihong Wu, Xiaomei Wang, Xiuzhu Gao, Junqi Niu
OBJECTIVES: The aim of this study was to evaluate the association between previous hepatitis B virus (HBV) infection and the severity of primary biliary cholangitis (PBC). PATIENTS AND METHODS: A total of 379 HBsAg-negative PBC patients were investigated between 2012 and 2017 in this study. Fifty-two of these patients underwent liver biopsy. The enrolled patients were divided into an anti-HBc-positive group and an anti-HBc-negative group; the patients with liver biopsy were further divided into early stage (stage I) and advanced stage (stages II, III, and IV) according to histological assessment...
February 16, 2018: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29438136/risk-factors-for-low-bone-mineral-density-in-pediatric-inflammatory-bowel-disease-the-positive-role-of-physical-activity
#8
Stefano Nobile, Richard J Grand, Helen M Pappa
OBJECTIVE: In pediatric inflammatory bowel disease (IBD), the prevalence of low bone mineral density (BMD) and bone fractures and the relationship between these are still debated. Our aim was to report data from a cohort of pediatric patients with IBD. PATIENTS AND METHODS: Cross-sectional assessment of growth and BMD [(dual-energy x-ray absorptiometry (DXA)] and retrospective chart review were performed to report the lifetime prevalence of bone fractures and clinical associations with patients' data...
February 12, 2018: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29438135/assessment-of-prognostic-performance-of-albumin-bilirubin-child-pugh-and-model-for-end-stage-liver-disease-scores-in-patients-with-liver-cirrhosis-complicated-with-acute-upper-gastrointestinal-bleeding
#9
Sofia A Xavier, Ricardo Vilas-Boas, Pedro Boal Carvalho, Joana T Magalhães, Carla M Marinho, José B Cotter
OBJECTIVE: The Albumin-Bilirubin (ALBI) score was developed recently to assess the severity of liver dysfunction. We aimed to assess its prognostic performance in patients with liver cirrhosis complicated with upper gastrointestinal bleeding (UGIB) while comparing it with Child-Pugh (CP) and Model for End-stage Liver Disease (MELD) scores. PATIENTS AND METHODS: This was a retrospective unicentric study, including consecutive adult patients with cirrhosis admitted for UGIB between January 2011 and November 2015...
February 12, 2018: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29432367/the-possible-relationship-between-campylobacter-spp-arcobacter-spp-and-patients-with-ulcerative-colitis
#10
Mustafa Akar, Fuat Aydin, Mustafa A Yurci, Seçil Abay, İhsan Ateş, Kemal Deniz
BACKGROUND AND AIMS: The role of bacterial infection in the pathogenesis of ulcerative colitis (UC) is under investigation. This study aims to (i) determine the prevalence of Campylobacter spp. and Arcobacter spp. in patients with UC, (ii) identify the antibiotic susceptibility of isolated agents, and (iii) investigate the role of these microorganisms in the pathogenesis and/or activation of UC. PATIENTS AND METHODS: Eighty patients with UC and 40 healthy individuals were included in the study...
February 9, 2018: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29432366/systemic-hemodynamic-response-to-terlipressin-predicts-development-of-hepatorenal-syndrome-and-survival-in-advanced-cirrhosis
#11
Georgios N Kalambokis, Ilias Tsiakas, Maria Christaki, Christina Koustousi, Leonidas Christou, Gerasimos Baltayiannis, Dimitrios Christodoulou
BACKGROUND: The aim of this study was to predict the occurrence of hepatorenal syndrome (HRS) and death in patients with advanced cirrhosis and ascites. PATIENTS AND METHODS: We retrospectively evaluated 2-year data of 78 patients with cirrhosis and ascites (Child-Pugh B/C: 45/43). The mean arterial pressure (MAP) and cardiac output (CO) were measured in all patients just before administration of 2 mg of terlipressin and 30 min later. Systemic vascular resistance (SVR) was calculated as MAP/CO...
February 9, 2018: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29420366/endoscopic-ultrasound-guided-fine-needle-aspiration-of-portal-vein-thrombosis-in-patients-with-chronic-liver-disease-and-suspicion-of-hepatocellular-carcinoma
#12
Antonio Z Gimeno Garcia, Jose R Aparicio, Angel Barturen, Miguel Moreno, David Nicolas-Perez, Enrique Quintero
BACKGROUND: Differentiation between benign and malignant portal vein thrombosis (PVT) in the setting of a hepatocellular carcinoma (HCC) is of paramount importance. Histological analysis is usually not carried out because of potential severe side effects of the percutaneous approach. Endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) may be safer and may guide the clinical management of patients with HCC. OBJECTIVE: To describe the feasibility of the EUS-FNA in a series of patients with HCC and PVT...
February 7, 2018: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29406437/combining-eastern-and-western-practices-for-safe-and-effective-endoscopic-resection-of-large-complex-colorectal-lesions
#13
Andrew Emmanuel, Shraddha Gulati, Margaret Burt, Bu'Hussain Hayee, Amyn Haji
BACKGROUND: Endoscopic resection of large colorectal polyps is well established. However, significant differences in technique exist between eastern and western interventional endoscopists. We report the results of endoscopic resection of large complex colorectal lesions from a specialist unit that combines eastern and western techniques for assessment and resection. PATIENTS AND METHODS: Endoscopic resections of colorectal lesions of at least 2 cm were included...
February 5, 2018: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29406436/clinical-practice-guidelines-from-the-french-national-society-of-coloproctology-in-treating-chronic-constipation
#14
Véronique Vitton, Henri Damon, Alban Benezech, Dominique Bouchard, Sarah Brardjanian, Charlène Brochard, Benoit Coffin, Nadia Fathallah, Thierry Higuero, Pauline Jouët, Anne-Marie Leroi, Laure Luciano, Guillaume Meurette, Thierry Piche, Alain Ropert, Jean-Marc Sabate, Laurent Siproudhis
Chronic constipation is a common symptom that regularly affects the quality of life of adult patients. Its treatment is mainly based on dietary rules, laxative drugs, perineal rehabilitation and surgical treatment. The French National Society of Coloproctology offers clinical practice recommendations on the basis of the data in the current literature, including those on recently developed treatments. Most are noninvasive, and the main concepts include the following: stimulant laxatives are now considered safe drugs and can be more easily prescribed as a second-line treatment; biofeedback therapy remains the gold standard for the treatment of anorectal dyssynergia that is resistant to medical treatment; transanal irrigation is the second-line treatment of choice in patients with neurological diseases, but it may also be proposed for patients without neurological diseases; and although interferential therapy may be a new promising treatment, it needs further evaluation...
February 5, 2018: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29406435/diagnostic-performance-of-a-new-noninvasive-test-for-nonalcoholic-steatohepatitis-using-a-simplified-histological-reference
#15
Thierry Poynard, Mona Munteanu, Frederic Charlotte, Hugo Perazzo, Yen Ngo, Olivier Deckmyn, Raluca Pais, Wassil Merrouche, Victor de Ledinghen, Philippe Mathurin, Vlad Ratziu
BACKGROUND: One of the unmet needs in patients with metabolic risks is the prediction of metabolic liver disease (MLD) by noninvasive tests (NITs). OBJECTIVE: The primary aim of this study was to construct a new quantitative test for the diagnosis of nonalcoholic steatohepatitis (NASH) using a simplified histological definition. PATIENTS AND METHODS: As a reference, we used a simplified histological definition of NASH derived from the FLIP-CRN-definition that does not require the presence of steatosis and the presence of both lobular inflammation and ballooning...
February 5, 2018: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29384798/frequency-and-type-of-drug-related-side-effects-necessitating-treatment-discontinuation-in-the-swiss-inflammatory-bowel-disease-cohort
#16
Sébastien Godat, Nicolas Fournier, Ekaterina Safroneeva, Pascal Juillerat, Andreas Nydegger, Alex Straumann, Stephan Vavricka, Luc Biedermann, Thomas Greuter, Montserrat Fraga, Karim Abdelrahman, Dieter Hahnloser, Bernhard Sauter, Gerhard Rogler, Pierre Michetti, Alain M Schoepfer
BACKGROUND AND AIM: Systematic analyses of inflammatory bowel disease (IBD) drug-related side effects necessitating treatment cessation in large cohorts of patients with IBD are scarce. We aimed to assess the frequency and type of drug-related side effects requiring drug cessation in patients included in the Swiss IBD Cohort. PATIENTS AND METHODS: A retrospective review was performed of data from the Swiss IBD Cohort physician questionnaires documenting a treatment cessation for the following drug categories: aminosalicylates, topical and systemic steroids, thiopurines, methotrexate, tumor necrosis factor-antagonists, and calcineurin inhibitors (tacrolimus, cyclosporine)...
January 30, 2018: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29384797/clarifying-the-role-of-c-reactive-protein-as-a-bacterial-infection-predictor-in-decompensated-cirrhosis
#17
David N Perdigoto, Pedro N Figueiredo, Luís F Tomé
INTRODUCTION: Bacterial infections are frequent in cirrhosis and may induce other deleterious complications. Ultrasensitive C-reactive protein (US-CRP), like other acute-phase proteins, is often considered useful in predicting bacterial infection in decompensated cirrhosis. However, US-CRP's reliability remains inconclusive, as inflammation in cirrhosis causes US-CRP synthesis independently of infection. The aim of this study was to clarify US-CRP's role as an infection predictor in decompensated cirrhosis...
January 30, 2018: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29384796/hepatocellular-carcinoma-recurrence-in-hepatitis-c-virus-related-cirrhosis-treated-with-direct-acting-antivirals-a-case-control-study
#18
Xavier Adhoute, Guillaume Penaranda, Jean Luc Raoul, Floriane Sellier, Paul Castellani, Valerie Oules, Herve Perrier, Gaëlle Lefolgoc, Bernard Pol, Manuela Campanile, Olivier Bayle, Patrick Beaurain, Olivier Monnet, Marc Bourlière
BACKGROUND: Direct-acting antivirals (DAAs) therapy against hepatitis C viral (HCV) infection has markedly improved the sustained viral response. However, recent studies have suggested an unsuspected high rate of hepatocellular carcinoma (HCC) recurrence. PATIENTS AND METHODS: A retrospective case-control study was carried out to investigate the impact of DAAs on tumor recurrence in patients with complete response to HCC treatment within our HCV-related cirrhosis cohort...
January 30, 2018: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29384795/nonalcoholic-fatty-liver-disease-biomarkers-as-diagnostic-tools-for-liver-damage-assessment-in-adult-patients-from-argentina
#19
Pamela Valva, Daniela Rios, Paola Casciato, Adrián Gadano, Omar Galdame, Eduardo Mullen, Gustavo Bertot, Elena de Matteo, María V Preciado
BACKGROUND: Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease whose prevalence has been increasing constantly and linked to the global obesity epidemic. The NAFLD histologic spectrum ranges from simple steatosis to nonalcoholic steatohepatitis (NASH), which can progress to cirrhosis and hepatocellular carcinoma. Liver biopsy is the only reliable means to diagnose and stage NASH, but its invasive nature limits its use. Therefore, the prediction of hepatic injury by means of the development of new noninvasive tests represents a growing medical need...
January 30, 2018: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29384794/high-rate-of-acute-pancreatitis-during-the-ramadan-fast
#20
Genady Drozdinsky, Amir Agabaria, Rona Zuker-Herman, Micheal J Drescher, Tony Bleetman, Shachaf Shiber
BACKGROUND: During the Ramadan fast Muslims celebrate a month of prayer, dawn-to-dusk fasting, and nightly feasts. We aimed to assess whether acute pancreatitis (AP) is more common during the Ramadan fast in individuals who celebrate it. PATIENTS AND METHODS: The study was carried out at the emergency department of Rabin Medical Center, Israel. We compared the occurrence of AP in a fasting population and a nonfasting population during the Ramadan versus the rest of the year...
January 30, 2018: European Journal of Gastroenterology & Hepatology
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