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European Journal of Gastroenterology & Hepatology

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https://www.readbyqxmd.com/read/29762255/ombitasvir-paritaprevir-ritonavir-dasabuvir-ribavirin-for-chronic-hepatitis-c-virus-genotype-1b-infected-cirrhotics-turquoise-iv
#1
Vasily Isakov, Dzmitry Paduta, Rolando M Viani, Jeffrey V Enejosa, Viktor Pasechnikov, Olga Znoyko, Pavel Ogurtsov, Pavel O Bogomolov, Marina V Maevskaya, Xiaotian Chen, Nancy S Shulman
OBJECTIVE: An estimated 336 per 100 000 people in Russia are infected with hepatitis C virus, including up to 75% with genotype (GT) 1b. In the TURQUOISE-II/-III trials, a 12-week regimen of the direct-acting antiviral agents ombitasvir (OBV), paritaprevir (PTV), ritonavir, and dasabuvir (DSV) in GT1b-infected patients with compensated cirrhosis resulted in 12-week sustained virologic response (SVR) rates of 100%. PATIENTS AND METHODS: In TURQUOISE-IV, GT1b-infected patients (n=36) from Russia and Belarus with compensated cirrhosis, who were treatment naive or previously treated with pegylated interferon/ribavirin (RBV), received OBV/PTV/ritonavir+DSV+RBV for 12 weeks...
May 14, 2018: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29762254/influence-of-regulatory-nlrc5-variants-on-colorectal-cancer-survival-and-5-fluorouracil-based-chemotherapy
#2
Calogerina Catalano, Miguel I da Silva Filho, Katerina Jiraskova, Veronika Vymetalkova, Miroslav Levy, Vaclav Liska, Ondrej Vycital, Alessio Naccarati, Ludmila Vodickova, Kari Hemminki, Pavel Vodicka, Alexander N R Weber, Asta Försti
BACKGROUND: NLRC5 is an interferon γ-inducible protein, which plays a role in immune surveillance with a potential influence on cancer survival. OBJECTIVE: We aimed to evaluate the effect of potential regulatory variants in NLRC5 on overall survival and survival after 5-fluorouracil (5-FU)-based therapy of colorectal cancer (CRC) patients. PATIENTS AND METHODS: We carried out a case-only study in a Czech population of 589 cases; 232 received 5-FU-based therapy...
May 14, 2018: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29757772/systematic-analysis-of-annual-health-resource-utilization-and-costs-in-hospitalized-patients-with-inflammatory-bowel-disease-in-switzerland
#3
Alain Schoepfer, Stephan R Vavricka, Beat Brüngger, Oliver Reich, Eva Blozik, Caroline Bähler
BACKGROUND AND AIMS: Real-life data on health resource utilization and costs of hospitalized patients with inflammatory bowel disease are lacking in Switzerland. We aimed to assess health resource utilization and costs during a 1-year follow-up period starting with an index hospitalization. PATIENTS AND METHODS: On the basis of claims data of the Helsana health insurance group, health resource utilization was assessed and costs reimbursed by mandatory basic health insurance [in Swiss Francs (CHF); 1 CHF=0...
May 11, 2018: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29742524/prevalence-and-incidence-of-hepatitis-delta-in-patients-with-chronic-hepatitis-b-in-spain
#4
Antonio Aguilera, Rocio Trastoy, Javier Rodríguez-Calviño, Tamara Manso, Carmen de Mendoza, Vicente Soriano
BACKGROUND: Hepatitis delta virus (HDV) is a defective agent that only replicates in the presence of the hepatitis B virus. Accordingly, HDV acquisition may occur as superinfection of HBsAg+ carriers or following acute dual HDV and hepatitis B virus exposure. Herein, we examined the global and incident rates of HDV infections in Spain. PATIENTS AND METHODS: The presence of anti-HDV antibody and new HDV superinfections was examined in all HBsAg+ patients who attended one large tertiary outclinic in Spain since year 2000...
May 8, 2018: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29738326/does-preoperative-enteral-or-parenteral-nutrition-reduce-postoperative-complications-in-crohn-s-disease-patients-a-meta-analysis
#5
Gregory T Brennan, Iris Ha, Christopher Hogan, Emily Nguyen, M M Jamal, Matthew L Bechtold, Douglas L Nguyen
OBJECTIVES: Crohn's disease (CD) patients frequently develop complications that require surgery for management. The high prevalence of malnutrition in CD patients presents a challenge because poor preoperative nutritional status has been shown to increase postoperative complications. In this study, we assessed whether preoperative enteral nutrition (EN) or total parenteral nutrition (TPN) decreases postoperative complications in CD patients. MATERIALS AND METHODS: A three-point systematic and comprehensive literature search was carried out on multiple databases followed by a meta-analysis with results presented as odds ratio (OR) using two models, the Mantel-Haenszel model and the DerSimonian and Laird model...
May 7, 2018: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29738325/automated-low-flow-ascites-pump-in-a-real-world-setting-complications-and-outcomes
#6
Philipp Solbach, Christoph Höner Zu Siederdissen, Freya Wellhöner, Nicolas Richter, Benjamin Heidrich, Henrike Lenzen, Port Kerstin, Katja Hueper, Michael P Manns, Heiner Wedemeyer, Elmar Jaeckel
BACKGROUND AND AIMS: The aim of this study was to investigate the Alfapump, an automated low-flow pump system for the treatment of refractory ascites (RA) as an alternative for repeated large-volume paracentesis in patients with contraindication for placement of a transjugular intrahepatic portosystemic shunt (TIPS) or liver transplantation. MATERIALS AND METHODS: In 21 consecutive patients with RA and contraindication for a placement of a TIPS, the Alfapump was implanted at Hannover Medical School between December 2012 and May 2016...
May 7, 2018: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29727380/human-mesenchymal-stem-cells-for-hepatitis-b-virus-related-acute-on-chronic-liver-failure-a-systematic-review-with-meta-analysis
#7
Bin Chen, Yong-Hong Wang, Jin-Qin Qian, Dong-Bo Wu, En-Qiang Chen, Hong Tang
BACKGROUND AND AIM: Acute-on-chronic liver failure (ACLF) is a condition with high mortality. New strategies are urgently required. The present review aims to provide a comprehensive understanding of the efficacy and safety of mesenchymal stem cells (MSC) treatment in patients with ACLF associated with hepatitis B virus infection. MATERIALS AND METHODS: The MEDLINE, Embase, and Cochrane Library databases were searched for the relevant publications. If appropriate, a meta-analysis was carried out for the following outcomes: survival rate, model for end-stage liver disease score, and liver function...
May 3, 2018: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29727379/severe-liver-failure-rather-than-cirrhosis-is-associated-with-mortality-in-patients-with-infectious-endocarditis-a-retrospective-case-control-study
#8
Manon Allaire, Jean-François D Cadranel, Christophe Bureau, Salah Zerkly, Thierry Thévenot, Armand Garioud, Patrice Cacoub, Gilles Macaigne, Laurent Alric, Vincent Jouannaud, Hortensia Lison, Carine Chagneau-Derrode, Alexandre Pariente, Agne Combining Grave Accent S Pe Combining Acute Accent Laquier, Marc Bourlie Combining Grave Accent Re, Xavier Causse, Jean-Baptiste Nousbaum, Je Combining Acute Accent Rôme Dumortier, Alexandre Louvet, Isabelle Rosa-He Combining Acute Accent Zode, Nathalie Ganne-Carrie Combining Acute Accent, Ryme Chentouh, Anis Sfaxi, Je Combining Acute Accent Rome Gournay, He Combining Acute Accent le Combining Grave Accent Ne Blasco-Perrin, Teresa Antonini, Laurent Spahr, Jean-Pierre Bronowicki, Christine Silvain, Vincent Di Martino, Jean-Didier Grange, Jacques Denis, Karine Dupont, Pierre Iaria, Isabelle Ollivier-Hourmand, Thong Dao
BACKGROUND: Data on infectious endocarditis (IE) in patients with liver cirrhosis (LC) are sparse. We aimed to describe the characteristics and predictors of mortality from IE in patients with LC. PATIENTS AND METHODS: Overall, 101 patients with LC and 101 controls with IE matched for sex, age, date of IE, and diabetes were retrospectively selected in 23 liver units between 2000 and 2013. RESULTS: Mean age was 60.8±10.5 and 60.6±11.5 years in LC and controls, respectively...
May 3, 2018: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29727381/predictive-ability-of-shear-wave-elastography-for-pruritus-in-chronic-hepatitis-c-patients-with-sustained-virological-response
#9
Yoshihiko Tachi, Takanori Hirai, Yuko Kojima, Yoji Ishizu, Takashi Honda, Teiji Kuzuya, Kazuhiko Hayashi, Masatoshi Ishigami, Hidemi Goto, Yoshiaki Katano
BACKGROUND AND AIMS: Pruritus is one of the complications with chronic liver disease and markedly worsens quality of life. However, the current status of pruritus in chronic hepatitis C patients who have achieved a sustained virological response (SVR) has not been clarified sufficiently. The aim of this study was to investigate the predictors of pruritus in post-SVR patients treated with direct-acting antivirals (DAA). PATIENTS AND METHODS: In this retrospective study, we enrolled 110 hepatitis C patients with SVR who underwent serial shear wave elastography before DAA therapy and at the end of treatment...
May 2, 2018: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29727383/hepatitis-c-virus-treatment-by-direct-acting-antivirals-in-successfully-treated-hepatocellular-carcinoma-and-possible-mutual-impact
#10
Mohamed Hassany, Aisha Elsharkawy, Amr Maged, Mai Mehrez, Noha Asem, Ahmed Gomaa, Zeinab Mostafa, Bahaa Abbas, Mohamad Soliman, Gamal Esmat
BACKGROUND AND AIMS: Treatment of hepatitis C virus (HCV) after successfully treated hepatocellular carcinoma (HCC) becomes possible with the introduction of direct-acting antivirals because of their favorable efficacy, safety, and short period of treatment. Few data are available on the results of treatment using different direct-acting antiviral regimens in successfully treated HCC and a lot of debate about its role in tumor recurrence. METHODS: Sixty-two HCV-related HCC patients were enrolled in the study after successfully treated HCC; the studied population included either Child-Pugh 'A' or 'B7'...
May 1, 2018: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29727382/evaluation-of-accuracy-of-elastography-point-quantification-versus-other-noninvasive-modalities-in-staging-of-fibrosis-in-chronic-hepatitis-c-virus-patients
#11
Rabab Fouad, Tamer Elbaz, Shereen Abdel Alem, Aisha Elsharkawy, Mohamed Negm, Marwa Khairy, Mohamed Hassany, Ahmed Cordie, Wafaa El Akel, Gamal Esmat
BACKGROUND: Elastography point quantification (ElastPQ) is a newly noninvasive method incorporated into a conventional ultrasound system for staging of liver fibrosis in patients with chronic liver diseases. AIM: The aim was to evaluate ElastPQ reproducibility and its accuracy in staging of liver fibrosis in hepatitis C virus (HCV) patients in comparison with transient elastography (TE) and fibrosis scores [FIB-4 and aspartate aminotransferase-to-platelet ratio index (APRI)] using liver biopsy as a reference standard and also to predict the sensitivity and specificity of ElastPQ as well as proposing a cut-off for advanced fibrosis...
May 1, 2018: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29727388/controlled-attenuation-parameter-for-steatosis-grading-in-chronic-hepatitis-c-compared-with-digital-morphometric-analysis-of-liver-biopsy-impact-of-individual-elastography-measurement-quality
#12
Leandro C Mendes, Paulo A Ferreira, Noelle Miotto, Letícia Zanaga, Maria S Lazarini, Eduardo S L Gonçales, Marcelo N Pedro, Fernando L Gonçales, Raquel S B Stucchi, Aline G Vigani
BACKGROUND AND OBJECTIVE: Controlled attenuation parameter (CAP) diagnostic performance for steatosis grading has been controversial and considerable observer-related variability in liver biopsy has been reported. This is a subanalysis of a larger chronic hepatitis C study on noninvasive fibrosis staging. MATERIALS AND METHODS: Patients were prospectively enrolled for paired liver biopsy and transient elastography. Biopsy fragments were subjected to digital morphometric steatosis quantification...
April 30, 2018: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29727387/a-return-to-harmful-alcohol-consumption-impacts-on-portal-hemodynamic-changes-following-alcoholic-hepatitis
#13
Laurent Spahr, Nicolas Goossens, Flavie Furrer, Melissa Dupuis, Sandrine Vijgen, Laure Elkrief, Emiliano Giostra, Laura Rubbia-Brandt, Jean-Louis Frossard
BACKGROUND: Increased hepatic venous pressure gradient (HVPG) plays a role in the clinical manifestations of alcoholic hepatitis (AH). The evolution of HVPG and the influence of alcohol use in the intermediate term are unclear. AIM: The aim of this study was to explore HVPG modifications following AH taking into consideration alcohol use and clinical manifestations. PATIENTS AND METHODS: Patients with AH (n=37; age 52 years; model for end-stage liver disease: 18...
April 30, 2018: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29727386/entyvio-lengthen-dose-interval-study-lengthening-vedolizumab-dose-interval-and-the-risk-of-clinical-relapse-in-inflammatory-bowel-disease
#14
Webber Chan, Nicole Lynch, Peter Bampton, Jeff Chang, Alvin Chung, Timothy Florin, David J Hetzel, Simon Jakobovits, Gregory Moore, Paul Pavli, Graham Radford-Smith, Lena Thin, Brandon Baraty, Craig Haifer, Yunki Yau, Rupert W L Leong
BACKGROUND: Vedolizumab (VDZ), an α4β7 anti-integrin antibody, is efficacious in the induction and maintenance of remission in ulcerative colitis (UC) and Crohn's disease (CD). In the GEMINI long-term safety study, enrolled patients received 4-weekly VDZ. Upon completion, patients were switched to 8-weekly VDZ in Australia. The clinical success rate of treatment de-escalation for patients in remission on VDZ has not been described previously. AIM: To determine the proportion of patients who relapsed after switching from 4 to 8-weekly VDZ, the mean time to relapse, and the recapture rate when switching back to 8-weekly dosing...
April 30, 2018: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29727385/secondary-prophylaxis-of-hepatic-encephalopathy-in-cirrhosis-of-liver-a-double-blind-randomized-controlled-trial-of-l-ornithine-l-aspartate-versus-placebo
#15
Shivakumar Varakanahalli, Barjesh C Sharma, Siddharth Srivastava, Sanjeev Sachdeva, Amol S Dahale
BACKGROUND AND AIMS: Hepatic encephalopathy (HE) is associated with a poor prognosis. There is no study on the prevention of recurrence of encephalopathy with L-ornithine L-aspartate (LOLA). PATIENTS AND METHODS: We conducted a double-blind randomized controlled trial at a tertiary center. Consecutive patients with cirrhosis who had recovered from HE were randomized to receive LOLA (6 g thrice daily) or similar amount of placebo by computer-based randomization for 6 months...
April 30, 2018: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29727384/response-to-schizophrenia-and-celiac-disease-which-is-the-role-of-the-gluten-free-diet
#16
Karn Wijarnpreecha, Veeravich Jaruvongvanich, Wisit Cheungpasitporn, Patompong Ungprasert
No abstract text is available yet for this article.
April 30, 2018: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29697458/effects-of-inflammatory-bowel-disease-treatment-on-the-risk-of-nonalcoholic-fatty-liver-disease-a-meta-analysis
#17
Kamolyut Lapumnuaypol, Napatt Kanjanahattakij, David Pisarcik, Charat Thongprayoon, Karn Wijarnpreecha, Wisit Cheungpasitporn
BACKGROUND: Epidemiological studies have demonstrated an association between inflammatory bowel disease (IBD) and an increased risk for the development of nonalcoholic fatty liver disease (NAFLD). However, the risk of NAFLD in IBD patients who receive different medical treatments including glucocorticoids, immunomodulators, and tumor necrosis factor-α inhibitors remains unclear. We aimed to assess whether the use of certain IBD medications is associated with the development of NAFLD...
April 24, 2018: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29697457/association-of-clinical-and-inflammatory-markers-with-small-bowel-capsule-endoscopy-findings-in-crohn-s-disease
#18
Ioannis V Mitselos, Konstantinos H Katsanos, Athina Tatsioni, Alexandros Skamnelos, Rami Eliakim, Epameinondas V Tsianos, Dimitrios K Christodoulou
BACKGROUND: Mucosal healing is an established treatment endpoint in Crohn's disease (CD). Still, clinical indices and inflammatory markers are used widely in CD surveillance. AIM: The aim of this study was to investigate the diagnostic performance as well as the relationship of C-reactive protein (CRP) and Crohn's Disease Activity Index (CDAI) with small bowel capsule endoscopy's (SBCE) inflammation scoring index, the Lewis Score (LS). PATIENTS AND METHODS: CDAI, CRP, and SBCE findings of 30 CD patients with isolated small bowel disease were retrieved from our academic institution patient records and were analyzed statistically...
April 24, 2018: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29688902/crohn-s-disease-and-pemphigus-is-there-an-association-a-population-based-study
#19
Khalaf Kridin, Doron Comaneshter, Arnon D Cohen
BACKGROUND: Although the coexistence of Crohn's disease (CD) and pemphigus has been reported in several individuals, the association between the two conditions was not investigated systematically in the past. A recent association between pemphigus and ulcerative colitis has been reported. The study aims to estimate the association between pemphigus and CD using a large-scale real-life computerized database. PATIENTS AND METHODS: A cross-sectional study was carried out comparing pemphigus patients with age-matched, sex-matched, and ethnicity-matched control participants in terms of the prevalence of CD...
April 23, 2018: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29688901/safety-and-efficacy-of-encapsulated-fecal-microbiota-transplantation-for-recurrent-clostridium-difficile-infection-a-systematic-review
#20
Umair Iqbal, Hafsa Anwar, Muhammad A Karim
BACKGROUND AND AIMS: Fecal microbial transplantation (FMT) has been shown to be effective for the treatment of recurrent clostridium difficile infection (CDI). The efficacy and safety of freeze-dried encapsulated FMT for the treatment of recurrent CDI is unclear. We performed a systematic review to evaluate and analyze the current evidence in this respect. MATERIALS AND METHODS: A systematic literature search was performed using the PubMed, Embase, and Medline databases until December 2017 to identify all original studies that investigated the role of administration of encapsulated FMT in recurrent CDI...
April 23, 2018: European Journal of Gastroenterology & Hepatology
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