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Current Opinion in Rheumatology

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https://www.readbyqxmd.com/read/28520683/socioeconomic-consequences-of-systemic-lupus-erythematosus
#1
Megan R W Barber, Ann E Clarke
PURPOSE OF REVIEW: The present review addresses recent literature investigating the socioeconomic consequences of systemic lupus erythematosus (SLE). We highlight the latest updates on health disparities affecting the SLE population, the direct and indirect economic costs of the disease, and less quantifiable costs such as reduced health-related quality of life (HRQoL). RECENT FINDINGS: Health disparities continue to exist among socially disadvantaged populations, including African Americans, Hispanics, and patients with decreased educational attainment and in poverty...
May 16, 2017: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/28520682/progress-in-the-pathogenesis-and-treatment-of-cardiac-manifestations-of-neonatal-lupus
#2
Peter Izmirly, Amit Saxena, Jill P Buyon
PURPOSE OF REVIEW: To provide new insights into pathogenesis, prevention and management of cardiac manifestations of neonatal lupus (cardiac neonatal lupus) and issues pertinent to all anti-SSA/Ro positive individuals of childbearing age. RECENT FINDINGS: Antibody specificity with high risk for cardiac neonatal lupus remains elusive, but high titers of Ro60, Ro52 or Ro52p200 antibodies appear to be required. Varying antibody specificities to the p200 region of Ro52 can induce first-degree block in a rodent model...
May 16, 2017: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/28509669/genetic-advances-in-systemic-lupus-erythematosus-an-update
#3
Lingyan Chen, David L Morris, Timothy J Vyse
PURPOSE OF REVIEW: More than 80 susceptibility loci are now reported to show robust genetic association with systemic lupus erythematosus (SLE). The differential functional effects of the risk alleles for the majority of these loci remain to be defined. Here, we review current SLE association findings and the recent progress in the annotation of noncoding regions of the human genome as well as the new technologies and statistical methods that can be applied to further the understanding of SLE genetics...
May 15, 2017: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/28463872/vitamin-d-and-rheumatoid-arthritis-an-ongoing-mystery
#4
Nicola L Bragazzi, Abdulla Watad, Shana G Neumann, Michael Simon, Stav B Brown, Arsalan Abu Much, Adam Harari, Shmuel Tiosano, Howard Amital, Yehuda Shoenfeld
PURPOSE OF REVIEW: In recent years, there has been a growing interest in the value of vitamin D and its effects on autoimmunity. The aim of this review is to summarize the current knowledge on the association between vitamin D and rheumatoid arthritis (RA) in terms of prevalence, disease activity, clinical expression, serology and gene polymorphisms of vitamin D receptors. RECENT FINDINGS: Studies have shown contrasting findings concerning the association between vitamin D levels and RA...
April 29, 2017: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/28426444/fracture-liaison-services
#5
Karine Briot
PURPOSE OF REVIEW: The purpose of this review is to report the evidence of beneficial effects of Fracture Liaison Service (FLS) including data regarding their impact on subsequent fracture, mortality risk and cost-effectiveness. This review also discusses the limitations of these data and the challenges faced during the implementation of FLS. RECENT FINDINGS: Recent studies showed the beneficial impact of implementation of FLS on the prevention of subsequent fracture risk, reduced mortality and cost-effectiveness...
April 19, 2017: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/28422773/infections-in-rheumatoid-arthritis
#6
Fabiola Atzeni, Ignazio Francesco Masala, Manuela di Franco, Piercarlo Sarzi-Puttini
PURPOSE OF REVIEW: The purpose of this review is to provide an update concerning recent advances in the evidence- based study of serious infections in patients with rheumatoid arthritis (RA) treated with biological drugs or conventional disease-modifying antirheumatic drugs (DMARDs), concentrating on studies published in the last 18 months. RECENT FINDINGS: New studies have further strengthened existing evidence relating the use of biological drugs to serious infections...
April 18, 2017: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/28394827/fibromyalgia-a-missed-comorbidity-in-spondyloarthritis-prevalence-and-impact-on-assessment-and-treatment
#7
Philip J Mease
PURPOSE OF REVIEW: Fibromyalgia is a clinical representation of the neurobiological phenomenon of central sensitization, characterized by chronic widespread pain, fatigue, sleep disturbance, and other symptoms. Fibromyalgia may occur in conjunction with chronic rheumatic diseases, driven by the effects of chronic pain and inflammation and likely influenced by the patient's genetic and psychoemotional background. This article reviews the data on prevalence of concomitant fibromyalgia and its impact on disease assessment in patients with spondyloarthritis (SpA) and psoriatic arthritis (PsA)...
April 7, 2017: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/28394826/osteoporosis-in-premenopausal-women
#8
Bente L Langdahl
PURPOSE OF REVIEW: The scope of this review was to review the newest developments in the context of the existing knowledge on premenopausal bone fragility. Fragility fractures are common in postmenopausal women and men and diagnostic criteria for osteoporosis have been agreed and multiple pharmacological treatments have been developed over the last 25 years. In premenopausal women, fragility fractures and very low bone mass are uncommon and osteoporosis in premenopausal women has therefore attracted much less interest...
April 7, 2017: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/28394825/body-composition-assessment-in-the-prediction-of-osteoporotic-fractures
#9
Mélany Hars, Andrea Trombetti
PURPOSE OF REVIEW: To give an overview of recent research findings and insights on the role of body composition assessment in fracture risk prediction. RECENT FINDINGS: While there is to date little doubt that bone mineral density (BMD) is a main pathogenic factor of osteoporotic fractures, recent studies have emphasized the independent contribution of body composition components, especially lean mass, to fracture risk. In this article, we address body composition changes with aging, before to focus on recent studies addressing the contribution of lean and fat mass to fracture risk, together with some hypothesized mechanisms and clinical implications...
April 7, 2017: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/28394824/from-microbiome-to-infectome-in-autoimmunity
#10
Dimitrios P Bogdanos, Lazaros I Sakkas
PURPOSE OF REVIEW: The current review discusses the pros and cons of the microbiome studies conducted in search of the association between microbiota and autoimmunity. RECENT FINDINGS: We focus on the role of infectome and autoinfectome as a bridge to link the findings of microbiome studies with those emerging from investigations of the role of specific viruses and antiviral responses as triggers of autoimmunity (through various mechanisms such as molecular mimicry)...
April 7, 2017: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/28394823/human-papilloma-virus-and-lupus-the-virus-the-vaccine-and-the-disease
#11
Yahel Segal, Michele Calabrò, Darja Kanduc, Yehuda Shoenfeld
PURPOSE OF REVIEW: Systemic lupus erythematosus (SLE) is a well known, widespread autoimmune disease, involving multiple organ systems, with a multifaceted, widely unmapped etiopathogenesis. Recently, a new aspect of morbidity has been described among SLE patients: infection with human papilloma virus (HPV). We set out to review data regarding the intricate relationship between the two and attempt to determine whether HPV may pose as a contributing factor to the development of SLE. RECENT FINDINGS: We relate to epidemiological, molecular and clinical data...
April 7, 2017: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/28394822/janus-kinase-signal-transducer-and-activator-of-transcription-pathways-in-spondyloarthritis
#12
Smriti K Raychaudhuri, Siba P Raychaudhuri
PURPOSE OF REVIEW: Cytokines are major drivers of autoimmunity, and biologic agents targeting cytokines have revolutionized the treatment of immune-mediated diseases. Janus kinase/signal transducer and activator of transcription (JAK-STAT) pathway represents a group of several intracellular molecules with a key role in signal pathways activated by growth factors and cytokines. These kinase proteins are associated with the signaling process of multiple key cytokines, which regulates various T-cell subpopulations and their effector cytokines...
April 7, 2017: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/28379860/silicone-breast-implants-and-autoimmune-rheumatic-diseases-myth-or-reality
#13
Jan Willem Cohen Tervaert, Maartje J Colaris, René R van der Hulst
PURPOSE OF REVIEW: In the present review, recent findings regarding silicone breast implants (SBIs) complicated by rheumatic autoimmune diseases are described. RECENT FINDINGS: Despite changes in the principal constituents of the silicone implants during the past 50 years, silicone remained an adjuvant that may 'bleed' and subsequently may be a chronic stimulus to the immune system resulting in similar clinical manifestations as 50 years ago. Silicones are spread throughout the body and can be detected in tissues and the central nervous system...
April 4, 2017: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/28376063/the-field-of-spondyloarthritis-coming-of-age
#14
Atul Deodhar
No abstract text is available yet for this article.
April 3, 2017: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/28376062/axial-spondyloarthritis-classification-criteria-the-debate-continues
#15
Maureen Dubreuil, Atul Deodhar
PURPOSE OF REVIEW: The Assessment of Spondyloarthritis International Society (ASAS) axial spondyloarthritis (axSpA) classification criteria marked a major step forward in SpA research, distinguishing axial from peripheral disease, and allowing earlier identification through MRI. This facilitated all aspects of research including epidemiology, therapeutics and patient outcomes. RECENT FINDINGS: The ASAS axSpA classification criteria have been applied broadly in research, and were validated in a recent meta-analysis of international studies...
April 3, 2017: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/28376061/new-developments-in-uveitis-associated-with-hla-b27
#16
James T Rosenbaum
PURPOSE OF REVIEW: Uveitis is the most common, clinically apparent, extra-articular manifestation of axial spondyloarthritis. This review summarizes recent publications related to this form of uveitis. RECENT FINDINGS: Studies published since the start of 2015 address the worldwide prevalence of human leukocyte antigen (HLA) B27-associated uveitis, the prevalence of axial spondyloarthritis among patients with B27-associated acute anterior uveitis (AAU), the genetics of AAU and some of the clinical implications of AAU...
April 3, 2017: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/28376060/minimal-disease-activity-in-axial-spondyloarthritis-the-need-of-the-hour-and-a-proposal-for-development
#17
Atul Deodhar, Anand Kumthekar, Maureen Dubreuil
PURPOSE OF REVIEW: Axial spondyloarthritis (axSpA) is a chronic inflammatory condition with articular and extra-articular manifestations. Remission, a state of absence of clinical and imaging signs of disease activity over time, is the goal of management. This review addresses the concept of minimal disease activity (MDA) in axSpA, which is less stringent than remission, and is closer to patient and provider acceptable low disease state. RECENT FINDINGS: Existing axSpA treatments improve physical function and quality of life, and lead to remission in a minority of patients...
April 3, 2017: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/28376059/skeletal-assessment-with-finite-element-analysis-relevance-pitfalls-and-interpretation
#18
Graeme Michael Campbell, Claus-C Glüer
PURPOSE OF REVIEW: Finite element models simulate the mechanical response of bone under load, enabling noninvasive assessment of strength. Models generated from quantitative computed tomography (QCT) incorporate the geometry and spatial distribution of bone mineral density (BMD) to simulate physiological and traumatic loads as well as orthopaedic implant behaviour. The present review discusses the current strengths and weakness of finite element models for application to skeletal biomechanics...
April 3, 2017: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/28376066/the-gut-microbiota-a-possible-factor-influencing-systemic-lupus-erythematosus
#19
Hadar Neuman, Omry Koren
PURPOSE OF REVIEW: Systemic lupus erythematosus (SLE) is an autoimmune disease of unknown cause. In recent years, with the emergence of microbiome research, changes in the gut microbiota composition have been correlated with a variety of autoimmune disorders, and several mechanisms linking these together have been suggested, including the hygiene theory, immune system activation and hormonal effects. It has therefore been suggested that gut microbiota may play a role in SLE. In this review, we summarize recent findings on the SLE-related microbiota compositions in both humans and rodents...
April 1, 2017: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/28376065/chikungunya-virus-and-autoimmunity
#20
Amir Tanay
PURPOSE OF REVIEW: Chikungunya virus (CHIKV) is a mosquito-borne alphavirus. Fever, rash and severe arthralgia are the hallmarks of chikungunya fever (CHIKF), the disease caused by this virus. The acute course of the disease usually lasts few weeks to months. Chronic, relapsing or persistent arthralgia and arthritis have been described mimicking rheumatoid arthritis (RA), requiring immunosuppressive drugs.The purpose of this review is to characterize both the chronic clinical course of CHIKF-associated arthritis and the immunological pathogenic mechanisms involved...
April 1, 2017: Current Opinion in Rheumatology
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