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Current Opinion in Rheumatology

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https://www.readbyqxmd.com/read/29256898/mechanisms-of-vascular-comorbidity-in-autoimmune-diseases
#1
György Nagy, Nóra Németh, Edit I Buzás
PURPOSE OF REVIEW: Alarming statistics support the clinical observations that because of cardiovascular comorbidities patients with inflammatory joint disease die significantly earlier despite successful anti-inflammatory therapy. RECENT FINDINGS: The reason for this earlier death is multifactorial and involves the complex genetic background, classical cardiovascular risk factors and anti-inflammatory therapy. We also point out the importance of several new influencing mechanisms, especially the diverseintercellular communication routes including extracellular vesicles and microRNAs in the development of cardiovascular comorbidities...
December 18, 2017: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/29251661/new-urate-lowing-therapies
#2
Abhishek Abhishek
PURPOSE OF REVIEW: To discuss recent studies of lesinurad and arhalofenate. RECENT FINDINGS: Lesinurad acts by blocking urate reabsorption channels URAT-1 and OAT-4. It has urate-lowering effect when used alone and in combination with xanthine oxidase inhibitors (XOIs). Its uricosuric activity depends on glomerular filtration, and its' efficacy is impaired at eGFR less than 30 ml/min. Lesinurad monotherapy (400 mg/day) associates with serum creatinine elevations...
December 14, 2017: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/29251660/epidemiology-of-systemic-lupus-erythematosus-an-update
#3
George Stojan, Michelle Petri
PURPOSE OF REVIEW: Systemic lupus erythematosus (SLE) is the prototypical systemic autoimmune disease with a significant disease burden across the world among different ethnic, racial, and age groups. The pathophysiological understanding of SLE is constantly evolving and with it, the need for a better definition of the disease itself, for understanding the risk among the different affected populations, and for identifying the factors responsible for the damage accrual through the years...
December 14, 2017: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/29251659/exercise-in-the-management-of-knee-and-hip-osteoarthritis
#4
Elizabeth Wellsandt, Yvonne Golightly
PURPOSE OF REVIEW: This review focuses on studies published during July 2001 to August 2017 of exercise as an intervention in knee and hip osteoarthritis, including its influence on an array of patient outcomes. RECENT FINDINGS: Studies continue to illustrate the efficacy of exercise in treating and managing osteoarthritis, with current literature more focused on the knee compared with the hip joint. Both traditional (e.g. strength, aerobic, flexibility) and more nontraditional (e...
December 14, 2017: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/29227354/current-views-on-the-pathogenesis-of-sjgren-s-syndrome
#5
Elena Pontarini, Davide Lucchesi, Michele Bombardieri
PURPOSE OF REVIEW: The purpose of this review is to provide an insight into the pathophysiological mechanisms involved in the pathogenesis of primary Sjgren's Syndrome (pSS), highlighting recent findings with potential therapeutic repercussions. RECENT FINDINGS: In the last 2 years, epigenetic analyses provided new insights into pSS pathogenesis. Characterization of DNA methylation patterns, chromatin structures and microRNA confirmed the importance of aberrant interferon and B-cell responses in the development of the disease...
December 8, 2017: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/29227353/epidemiology-of-osteoarthritis-literature-update
#6
Ernest R Vina, C Kent Kwoh
PURPOSE OF REVIEW: The purpose of this review is to highlight recent studies of osteoarthritis epidemiology, including research on prevalence, disease impact, and potential risk factors. RECENT FINDINGS: Osteoarthritis is highly prevalent in the United States and around the globe. It is a leading cause of disability and can negatively impact people's physical and mental well being. Healthcare resources and costs associated with managing the disease can be substantial...
December 8, 2017: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/29227352/epidemiology-of-axial-spondyloarthritis-an-update
#7
Runsheng Wang, Michael M Ward
PURPOSE OF REVIEW: To provide an update of the prevalence and incidence of axial spondyloarthritis in the general population and in patients with spondyloarthritis-related conditions, environmental risk factors for ankylosing spondylitis, progression from nonradiographic axial spondyloarthritis to ankylosing spondylitis, mortality, and risks for cardiovascular events in patients with ankylosing spondylitis. RECENT FINDINGS: Increasingly, administrative healthcare data have been used to study disease frequency and outcomes...
December 8, 2017: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/29227355/basic-calcium-phosphate-crystal-associated-musculoskeletal-syndromes-an-update
#8
Ann K Rosenthal
PURPOSE OF REVIEW: Basic calcium phosphate (BCP) crystals are associated with two important musculoskeletal syndromes. Deposition of BCP crystals in tendons, bursae, and other soft tissues around joints causes calcific periarthritis, whereas intra-articular BCP crystals contribute to osteoarthritis and cause the highly destructive arthritis known as Milwaukee Shoulder Syndrome. The epidemiology and natural history of these syndromes are poorly understood, and because the pathogenesis remains unclear, few targeted therapies are available...
December 7, 2017: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/29206660/recent-developments-in-systemic-lupus-erythematosus-pathogenesis-and-applications-for-therapy
#9
Mindy S Lo, George C Tsokos
PURPOSE OF REVIEW: Systemic lupus erythematosus (SLE) pathogenesis is complex. Aberrancies of immune function that previously were described but not well understood are now becoming better characterized, in part through recognition of monogenic cases of lupus-like disease. RECENT FINDINGS: We highlight here recent descriptions of metabolic dysfunction, cytokine dysregulation, signaling defects, and DNA damage pathways in SLE. Specifically, we review the effects of signaling abnormalities in mammalian target of rapamycin, Rho kinase, Bruton's tyrosine kinase, and Ras pathways...
December 4, 2017: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/29206659/what-are-the-dominant-cytokines-in-early-rheumatoid-arthritis
#10
Laura A Ridgley, Amy E Anderson, Arthur G Pratt
PURPOSE OF REVIEW: Rheumatoid arthritis is a systemic disease of evolving immune dysregulation that culminates in joint destruction and disability. The principle by which pro-inflammatory cytokines may be therapeutically targeted to abrogate disease is well established, but has yet to translate into reliable cures for patients. Emerging insights into cytokine-mediated pathobiology during rheumatoid arthritis development are reviewed, and their implications for future treatment strategies considered...
December 4, 2017: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/29194109/crystalline-arthropathy-and-bone-health
#11
Ian Chang, David Gazeley
PURPOSE OF REVIEW: The purpose of this review is to provide insight on the proposed association between crystal arthritis and bone health. Crystal arthritis is the most common type of inflammatory arthritis, and fractures contribute to significant morbidity and mortality, therefore, the relationship between the two is of clinical importance. RECENT FINDINGS: There have been variable findings regarding hyperuricemia, low bone density and risk of fracture. A recent systematic review and meta-analysis of available literature showed a correlation between increased serum uric acid and lower risk of fracture...
November 30, 2017: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/29194108/epigenetics-of-inflammatory-arthritis
#12
Deepa Hammaker, Gary S Firestein
PURPOSE OF REVIEW: Aberrant epigenetic changes in DNA methylation, histone marks, and noncoding RNA expression regulate the pathogenesis of many rheumatic diseases. The present article will review the recent advances in the epigenetic profile of inflammatory arthritis and discuss diagnostic biomarkers and potential therapeutic targets. RECENT FINDINGS: Methylation signatures of fibroblast-like synoviocytes not only distinguish rheumatoid arthritis (RA) and osteoarthritis (OA), but also early RAs from late RAs or juvenile idiopathic arthritis...
November 30, 2017: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/29076891/a-review-of-current-management-of-vasculo-behcet-s
#13
Mira Merashli, Rozana El Eid, Imad Uthman
PURPOSE OF REVIEW: To give an overview of recently published articles about the management of vasculo-Behcet's with particular emphasis on anticoagulation. RECENT FINDINGS: Biologic agents are emerging as a potential therapeutic option in refractory vasculo-Behcet with a good safety profile. Evidence further shows that following nonpulmonary aneurysm repair, there is a reduced risk of recurrent aneurysmal formation at the operative site in patients treated with immunosuppressants in addition to their surgery, than those undergoing surgical intervention alone...
January 2018: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/29040157/development-and-use-of-biochemical-markers-in-osteoarthritis-current-update
#14
Anne C Bay-Jensen, Christian S Thudium, Ali Mobasheri
PURPOSE OF REVIEW: There is an increasing demand for noninvasive and descriptive biochemical markers (biomarkers) in osteoarthritis; for enabling early drug development (including translational research), evaluating clinical trial at an early stage and for subtyping. Purpose of the review is to review and comment on current availability of such biomarkers. RECENT FINDINGS: Many different biomarkers have been tested in the last 18 months. The main focus has been on testing whether the biomarkers, whether is reflect joint tissue turnover or inflammatory status, can differentiate osteoarthritis patients from healthy controls or whether the biomarkers are associated with progression...
January 2018: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/29040156/accelerated-atheromatosis-and-arteriosclerosis-in-primary-systemic-vasculitides-current-evidence-and-future-perspectives
#15
Ourania D Argyropoulou, Athanase D Protogerou, Petros P Sfikakis
PURPOSE OF REVIEW: Primary systemic vasculitides (PSV) encompass a subset of autoimmune diseases, characterized by inflammation of blood vessels. Atheromatosis and arteriosclerosis may be accelerated in several PSV and account for the increased rate of cardiovascular morbidity that some exhibit. We aimed to summarize recent studies reporting on the acceleration of atheromatosis and/or arteriosclerosis in each type of PSV, using state-of-the-art noninvasive vascular biomarkers with clinical value as end points...
January 2018: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/29035933/psoriatic-arthritis-new-evidence-for-old-concepts
#16
Enrique R Soriano, Josefina Marin, Maria L Acosta-Felquer
PURPOSE OF REVIEW: The review gives an updated overview of some of the new concepts in the management of psoriatic arthritis (PsA): early diagnosis, remission as an objective, treat-to-target, and treatment guidelines. RECENT FINDINGS: Early diagnosis, targeting remission as part of a treatment strategy, and new guidelines providing evidence-based support to these concepts are main topics in recent publications. SUMMARY: Dermatologists and rheumatologists should work together to reduce the number of patients remaining undiagnosed, and the time to do so...
January 2018: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/29035929/vasculitis-2018-the-bench-and-the-bedside
#17
Hasan Yazici, Yusuf Yazici
No abstract text is available yet for this article.
January 2018: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/29035927/the-2018-landscape-of-ra-psa-and-spa-pathogenesis
#18
Jose U Scher
No abstract text is available yet for this article.
January 2018: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/28984648/new-treatment-paradigms-in-spondyloarthritis
#19
Leonieke J J van Mens, Marleen G H van de Sande, Dominique L P Baeten
PURPOSE OF REVIEW: The review presents the recent rapid expansion of therapeutical options in spondyloarthritis. Additionally, it focuses on the importance of additional questions raised by the growing therapeutic possibilities related to the optimal use of these drugs. RECENT FINDINGS: The emergence of new treatment options opens new avenues and opportunities for treating patients with nonresponse, contraindications, or intolerance for classic drugs. However, it becomes more relevant than ever to define not only drugs and treatment options but also treatment strategies...
January 2018: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/28957962/neutrophil-extracellular-traps-in-vasculitis-friend-or-foe
#20
Daniel Söderberg, Mårten Segelmark
PURPOSE OF REVIEW: Neutrophil extracellular traps (NETs) can be found at the sites of vascular lesions and in the circulation of patients with active small vessel vasculitis. Neutrophils from vasculitis patients release more NETs in vitro, and NETs have properties that can harm the vasculature both directly and indirectly. There are several ways to interfere with NET formation, which open for new therapeutic options. However, there are several types of NETs and different mechanisms of NET formation, and these might have different effects on inflammation...
January 2018: Current Opinion in Rheumatology
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