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Current Opinion in Rheumatology

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https://www.readbyqxmd.com/read/28072592/metabolic-syndrome-associated-osteoarthritis
#1
Alice Courties, Jérémie Sellam, Francis Berenbaum
PURPOSE OF REVIEW: Interest in the metabolic syndrome-associated osteoarthritis phenotype is increasing. Here, we summarize recently published significant findings. RECENT FINDINGS: Meta-analyses confirmed an association between type 2 diabetes and osteoarthritis and between cardiovascular diseases and osteoarthritis. Recent advances in the study of metabolic syndrome-associated osteoarthritis have focused on a better understanding of the role of metabolic diseases in inducing or aggravating joint damage...
January 7, 2017: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/28072591/osteoporosis-fracture-epidemiology-update-2016
#2
Jane A Cauley
PURPOSE OF REVIEW: The purpose of this review is to provide an update on osteoporosis epidemiology. The focus is on fractures because fractures are the most important clinical consequence of osteoporosis. Studies published over the past 18 months are identified and reviewed. Finally, the clinical impact of these new findings is discussed. RECENT FINDINGS: Important research in 2015-2016 include analyses of screening and rescreening in younger women and older men, risk factors for hip fractures in older men, obesity and weight loss/gain, and risk of fracture...
January 7, 2017: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/28072590/incorporating-the-patient-s-perspective-in-outcomes-research
#3
Betty Hsiao, Liana Fraenkel
PURPOSE OF REVIEW: Incorporation of the patients' perspective in clinical research is critical to ensure that outcomes measured reflect those, which matter most to patients. This review summarizes recent efforts to include the patients' perspective in the development of outcome measures and the importance of encouraging patient participation in decision-making and self-management. RECENT FINDINGS: Since the inclusion of fatigue as a patient-endorsed core outcome measure in rheumatoid arthritis (RA) trials, OMERACT has been instrumental in advocating for patient involvement in the development of core domains and instruments; current endeavors include cultivating an understanding of remission through the eyes of patients and gaining a sense of how to measure features of pain and 'stiffness' deemed as important to patients...
January 7, 2017: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/27984323/use-of-large-healthcare-databases-for-rheumatology-clinical-research
#4
Rishi J Desai, Daniel H Solomon
PURPOSE OF REVIEW: Large healthcare databases, which contain data collected during routinely delivered healthcare to patients, can serve as a valuable resource for generating actionable evidence to assist medical and healthcare policy decision-making. In this review, we summarize use of large healthcare databases in rheumatology clinical research. RECENT FINDINGS: Large healthcare data are critical to evaluate medication safety and effectiveness in patients with rheumatologic conditions...
December 15, 2016: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/27977623/the-contribution-of-autoantibodies-to-post-translationally-modified-proteins-to-inflammatory-arthritis
#5
Diane van der Woude, René E M Toes
PURPOSE OF REVIEW: This article provides an overview of the recent findings present in the field of antimodified protein antibodies and their relevance for rheumatic disease, with a focus on rheumatoid arthritis. RECENT FINDINGS: Next to anticitrullinated protein antibodies, also other antimodified protein antibodies such as anticarbamylated protein antibodies or antiacetylated protein antibodies are emerging. Likewise, their possible pathological contributions are getting detailed attention...
December 12, 2016: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/27941392/a-new-era-of-quality-measurement-in-rheumatology-electronic-clinical-quality-measures-and-national-registries
#6
Chris Tonner, Gabriela Schmajuk, Jinoos Yazdany
PURPOSE OF REVIEW: This article reviews the evolution of quality measurement in rheumatology, highlighting new health-information technology infrastructure and standards that are enabling unprecedented innovation in this field. RECENT FINDINGS: Spurred by landmark legislation that ties physician payment to value, the widespread use of electronic health records, and standards such as the Quality Data Model, quality measurement in rheumatology is rapidly evolving...
December 9, 2016: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/27941391/mechanobiological-implications-of-articular-cartilage-crystals
#7
Alyssa K Carlson, Carley N McCutchen, Ronald K June
PURPOSE OF REVIEW: Calcium crystals exist in both pathological and normal articular cartilage. The prevalence of these crystals dramatically increases with age, and crystals are typically found in osteoarthritic cartilage and synovial fluid. Relatively few studies have examined the effects of crystals on cartilage biomechanics or chondrocyte mechanotransduction. The purpose of this review is to describe how crystals could influence cartilage biomechanics and mechanotransduction in osteoarthritis...
December 9, 2016: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/27941390/mesenchymal-stem-cells-for-the-management-of-rheumatoid-arthritis-immune-modulation-repair-or-both
#8
Sharon Ansboro, Anke J Roelofs, Cosimo De Bari
PURPOSE OF REVIEW: Mesenchymal stromal/stem cells (MSCs) have potent anti-inflammatory and immunomodulatory properties, in addition to their ability to form cartilage and bone. The purpose of this review is to highlight recent developments and current knowledge gaps in our understanding of the protective effects of MSCs against inflammatory arthritis, and to discuss their clinical exploitation for the treatment of rheumatoid arthritis (RA). RECENT FINDINGS: The weight of evidence for protective mechanisms of exogenously administered MSCs is on immunomodulatory effects, including inhibition of dendritic cell maturation, polarization of macrophages to an anti-inflammatory phenotype, and activation of regulatory T cells, thereby dampening inflammation and preventing joint damage...
December 9, 2016: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/27941389/factors-modulating-the-inflammatory-response-in-acute-gouty-arthritis
#9
Maartje C Cleophas, Tania O Crişan, Leo A B Joosten
PURPOSE OF REVIEW: Gout is a common debilitating form of arthritis and despite our extensive knowledge on the pathogenesis its prevalence is still rising quickly. In the current review, we provide a concise overview of recent discoveries in factors tuning the inflammatory response to soluble uric acid and monosodium urate crystals. RECENT FINDINGS: It appears that soluble uric acid has a much larger role to play than just being a risk factor for gout. It may have widespread consequences for systemic inflammation and the development of metabolic syndrome...
December 9, 2016: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/27926541/major-unanswered-questions-in-the-clinical-gout-field
#10
Lisa K Stamp
PURPOSE OF REVIEW: Although gout is one of the most common forms of inflammatory arthritis, it has been relatively neglected until recently. Despite progress in many areas of pathophysiology and genetics of gout and the development of new urate lowering therapies, there remain a number of unanswered clinical questions. With the resurgence of interest in gout it is important to recognize key aspects of gout management that remain challenging and require further research. RECENT FINDINGS: The unanswered clinical issues outlined in this review are basic aspects of gout management that clinicians treating people with gout face on a daily basis and include when urate lowering therapy should be commenced, the most appropriate target serum urate, use of prophylaxis when starting urate lowering therapy and the most appropriate urate lowering therapy, particularly for those with chronic kidney disease...
December 6, 2016: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/27926540/the-novel-interleukin-1-cytokine-family-members-in-inflammatory-diseases
#11
Madelaine Hahn, Silke Frey, Axel J Hueber
PURPOSE OF REVIEW: This review provides an update on the new interleukin-1 (IL-1) cytokine family members in inflammatory diseases with focus on recent findings concerning the family members IL-36, IL-37, and IL-38 and their different expression patterns. RECENT FINDINGS: The IL-1 cytokines are known to be involved in many different inflammatory and autoimmune diseases. The latest IL-1 family members, IL-36, IL-37, and IL-38 have been shown to be differently regulated during course of disease...
December 6, 2016: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/27906774/lessons-from-characterization-and-treatment-of-the-autoinflammatory-syndromes
#12
Ivona Aksentijevich, Michael F McDermott
PURPOSE OF REVIEW: The list of genes associated with systemic inflammatory diseases has been steadily growing because of the explosion of new genomic technologies. Significant advances in the past year have deepened our understanding of the molecular mechanisms linked to inflammation and elucidated insights on the efficacy of specific therapies for these and related conditions. We review the molecular pathogenesis of four recently characterized monogenic autoinflammatory diseases: haploinsufficiency of A20, otulipenia, a severe form of pyrin-associated disease, and a monogenic form of systemic juvenile idiopathic arthritis...
November 30, 2016: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/27906752/recent-developments-in-emerging-therapeutic-targets-of-osteoarthritis
#13
Margaret Man-Ger Sun, Frank Beier, Michael A Pest
PURPOSE OF REVIEW: Despite the tremendous individual suffering and socioeconomic burden caused by osteoarthritis, there are currently no effective disease-modifying treatment options. This is in part because of our incomplete understanding of osteoarthritis disease mechanism. This review summarizes recent developments in therapeutic targets identified from surgical animal models of osteoarthritis that provide novel insight into osteoarthritis pathology and possess potential for progression into preclinical studies...
January 2017: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/27906751/an-update-on-vasculitides-lumps-and-constructs
#14
Hasan Yazici, Yusuf Yazici
No abstract text is available yet for this article.
January 2017: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/27902501/editorial-introductions
#15
(no author information available yet)
No abstract text is available yet for this article.
January 2017: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/27875351/pathogenesis-and-immunotherapy-in-cutaneous-psoriasis-what-can-rheumatologists-learn
#16
Helen Alexander, Frank O Nestle
PURPOSE OF REVIEW: This review presents our current understanding of the pathogenesis and treatment of psoriasis with a particular focus on recent areas of research and emerging concepts. RECENT FINDINGS: Psoriasis arises in genetically predisposed individuals who have an abnormal innate and adaptive immune response to environmental factors. Recent studies have identified novel genetic, epigenetic and immunological factors that play a role in the disease pathogenesis...
January 2017: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/27787337/approach-to-cutaneous-vasculitides-with-special-emphasis-on-small-vessel-vasculitis-histopathology-and-direct-immunofluorescence
#17
Cuyan Demirkesen
PURPOSE OF REVIEW: The present review will focus on recent publications in cutaneous vasculitides. RECENT FINDINGS: Some histopathological and clinical features, such as papillary dermal edema, perivascular C3 deposition, clinically evident edema, and lesions above the waist, may point out renal or gastrointestinal involvement in Henoch-Schönlein purpura (HSP). HSP associated with familial Mediterranean fever differs from typical isolated HSP by showing no deposits of IgA, much younger age, and location of the lesions on the face or the trunk...
January 2017: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/27755180/role-of-low-grade-inflammation-in-osteoarthritis
#18
Carla R Scanzello
PURPOSE OF REVIEW: Inflammatory changes in joint tissues can be detected by modern imaging techniques in osteoarthritis patients, but may be clinically subtle compared with many other types of arthritis. These changes associate with disease progression and clinical severity, and many inflammatory mediators may have biomarker utility. Moreover, a number of inflammatory mechanisms play a role in animal models of disease, but it is still not clear which mechanisms predominate and might be therapeutically manipulated most effectively...
January 2017: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/27755179/imaging-in-knee-osteoarthritis
#19
Win M Oo, James M Linklater, David J Hunter
PURPOSE OF REVIEW: Osteoarthritis is the most prevalent and disabling disease still necessitating research in pathogenic mechanisms, predictors of disease progression and responsive techniques to detect the slow structural changes within a short time frame. In this scenario, imaging modalities are essential. With recent advancements in technology and availability of large longitudinal datasets, tremendous advances are occurring. The present review discusses and summarizes recent original publications in this area...
January 2017: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/27755178/genetic-association-studies-in-osteoarthritis-is-it-fairytale
#20
Sophie C Warner, Ana M Valdes
PURPOSE OF REVIEW: Osteoarthritis is a common complex disorder with a strong genetic component. Other identified risk factors such as increasing age and overweight do not fully explain the risk of osteoarthritis. Here, we highlight the main findings from genetic association studies on osteoarthritis to date. RECENT FINDINGS: Currently, genetic association studies have identified 21 independent susceptibility loci for osteoarthritis. Studies have focused on hip, knee and hand osteoarthritis, as well as posttotal joint replacement and minimum joint space width, a proxy for cartilage thickness...
January 2017: Current Opinion in Rheumatology
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