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Current Opinion in Rheumatology

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https://www.readbyqxmd.com/read/28319486/igg4-related-disease
#1
Emanuele Bozzalla Cassione, John H Stone
PURPOSE OF REVIEW: Remarkable insights have been gleaned recently with regard to the pathophysiology of IgG4-related disease (IgG4-RD). These findings have direct implications for the development of targeted strategies for the treatment of this condition. RECENT FINDINGS: Oligoclonal expansions of cells of both the B and T lymphocyte lineages are present in the blood of patients with IgG4-RD. Oligoclonal expansions of plasmablasts are a good biomarker for disease activity...
March 17, 2017: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/28306596/biosimilars-implications-for-rheumatoid-arthritis-therapy
#2
Stanley Cohen, Jonathan Kay
PURPOSE OF REVIEW: Abbreviated pathways for the approval of biosimilars have been established in the European Union (EU), the United States, and other countries. Biosimilar TNF inhibitors have been available in South Korea and the EU since 2012 and 2013, respectively, and the first biosimilar infliximab was introduced to the clinic in the United States in November 2016. Five TNF inhibitor biosimilars have now been approved, and many other biosimilars to treat rheumatoid arthritis and other inflammatory diseases are in development...
March 16, 2017: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/28306595/update-on-maintenance-therapy-for-granulomatosis-with-polyangiitis-and-microscopic-polyangiitis
#3
Ora Singer, W Joseph McCune
PURPOSE OF REVIEW: The antineutrophilic cytoplasmic antibody (ANCA)-associated vasculitides are a group of rare systemic diseases. The past several years have seen major therapeutic advances in the treatment of granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA). The success rate in induction of remission is high, but reducing the high incidence of relapses remains a therapeutic challenge. RECENT FINDINGS: Studies have shown no improvement in relapse rates in GPA and MPA over the past 2 decades...
March 16, 2017: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/28240614/diagnostic-and-therapeutic-considerations-in-patients-with-hypogammaglobulinemia-after-rituximab-therapy
#4
Ruba Kado, Georgiana Sanders, W Joseph McCune
PURPOSE OF REVIEW: There are no established guidelines for evaluating and treating hypogammaglobulinemia in patients with rheumatic disease who receive B-cell depleting agents. The purpose of this article is to review findings in the work-up and treatment of common variable immunodeficiency (CVID) that can guide our evaluation of patients with autoimmune disease who develop hypogammaglobulinemia after rituximab/B-cell depleting therapy. RECENT FINDINGS: Infection rates are higher in rheumatic disease patients who develop hypogammaglobulinemia than those who do not...
February 24, 2017: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/28207496/recent-advances-in-the-pathogenesis-prediction-and-management-of-rheumatoid-arthritis-associated-interstitial-lung-disease
#5
Cheilonda Johnson
PURPOSE OF REVIEW: To provide an overview of recently published articles covering interstitial lung disease associated with rheumatoid arthritis (RA-ILD). RECENT FINDINGS: Over the past year, many studies replicated previous findings in more diverse and occasionally larger populations internationally. Specifically, the association among cigarette smoking, high rheumatoid factor titer, elevated anticitrullinated protein antibody (ACPA) levels, and RA-ILD was strengthened...
February 15, 2017: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/28207495/lipids-and-lipid-changes-with-synthetic-and-biologic-disease-modifying-antirheumatic-drug-therapy-in-rheumatoid-arthritis-implications-for-cardiovascular-risk
#6
Elena Myasoedova
PURPOSE OF REVIEW: To highlight recently published studies addressing lipid changes with disease-modifying antirheumatic drug use and outline implications on cardiovascular outcomes in rheumatoid arthritis (RA). RECENT FINDINGS: Growing evidence suggests lower lipid levels are present in patients with active RA vs. general population, and significant modifications of lipid profile with inflammation suppression. Increase in lipid levels in patients with RA on synthetic and biological disease-modifying antirheumatic drugs may be accompanied by antiatherogenic changes in lipid composition and function...
February 15, 2017: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/28207494/causes-and-consequences-of-fatigue-in-rheumatoid-arthritis
#7
Patricia Katz
PURPOSE OF REVIEW: To review current information on the causes, treatments, and consequences of fatigue in rheumatoid arthritis. RECENT FINDINGS: Disease activity (inflammation, pain, joint symptoms) is associated with greater fatigue. However, disease activity per se accounts for only a small portion of fatigue, and rheumatoid arthritis medications that reduce disease activity have small effects on fatigue. Instead, factors outside the direct effects of rheumatoid arthritis, such as obesity, physical inactivity, sleep disturbance, and depression, explain the majority of variation in fatigue...
February 15, 2017: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/28207493/treatment-of-lupus-nephritis-current-paradigms-and-emerging-strategies
#8
Maria Dall'Era
PURPOSE OF REVIEW: Lupus nephritis is the most common organ-threatening manifestation of lupus and continues to result in end-stage renal disease. This review describes the contemporary treatment of lupus nephritis as well as emerging therapeutic strategies. RECENT FINDINGS: Lupus nephritis management consists of an initial (induction) phase and a maintenance (extended) phase in which steroids are used in combination with another immunosuppressive medication. Current treatments are incompletely effective and associated with substantial toxicity...
February 15, 2017: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/28207492/international-collaboration-including-patients-is-essential-to-develop-new-therapies-for-patients-with-myositis
#9
Ingrid E Lundberg, Jiri Vencovsky
PURPOSE OF REVIEW: To discuss the needs for international collaborations between investigators in different disciplines working with myositis and with patients with myositis. RECENT FINDINGS: Recent advances in detection of several myositis-specific autoantibodies that are associated with distinct clinical phenotypes, will enable studies in new well defined clinically homogenous subgroups of myositis This is likely to lead to development of new information on molecular pathogenesis that might be different in different myositis subgroups...
February 15, 2017: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/28121705/editorial-introductions
#10
(no author information available yet)
No abstract text is available yet for this article.
March 2017: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/28118202/from-mechanism-to-therapies-in-systemic-lupus-erythematosus
#11
Michael A Paley, Vibeke Strand, Alfred H J Kim
PURPOSE OF REVIEW: Systemic lupus erythematosus (SLE) is a disabling and deadly disease. Development of novel therapies for SLE has historically been limited by incomplete understanding of immune dysregulation. Recent advances in lupus pathogenesis, however, have led to the adoption or development of new therapeutics, including the first Food and Drug Administration-approved drug in 50 years. RECENT FINDINGS: Multiple cytokines (interferon, B lymphocyte stimulator, IL-6, and IL-17), signaling pathways (Bruton's Tyrosine Kinase, Janus kinase/signal transducer and activator of transcription), and immune cells are dysregulated in SLE...
March 2017: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/28072592/metabolic-syndrome-associated-osteoarthritis
#12
Alice Courties, Jérémie Sellam, Francis Berenbaum
PURPOSE OF REVIEW: Interest in the metabolic syndrome-associated osteoarthritis phenotype is increasing. Here, we summarize recently published significant findings. RECENT FINDINGS: Meta-analyses confirmed an association between type 2 diabetes and osteoarthritis and between cardiovascular diseases and osteoarthritis. Recent advances in the study of metabolic syndrome-associated osteoarthritis have focused on a better understanding of the role of metabolic diseases in inducing or aggravating joint damage...
March 2017: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/28072591/osteoporosis-fracture-epidemiology-update-2016
#13
Jane A Cauley
PURPOSE OF REVIEW: The purpose of this review is to provide an update on osteoporosis epidemiology. The focus is on fractures because fractures are the most important clinical consequence of osteoporosis. Studies published over the past 18 months are identified and reviewed. Finally, the clinical impact of these new findings is discussed. RECENT FINDINGS: Important research in 2015-2016 include analyses of screening and rescreening in younger women and older men, risk factors for hip fractures in older men, obesity and weight loss/gain, and risk of fracture...
March 2017: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/28072590/incorporating-the-patient-s-perspective-in-outcomes-research
#14
Betty Hsiao, Liana Fraenkel
PURPOSE OF REVIEW: Incorporation of the patients' perspective in clinical research is critical to ensure that outcomes measured reflect those, which matter most to patients. This review summarizes recent efforts to include the patients' perspective in the development of outcome measures and the importance of encouraging patient participation in decision-making and self-management. RECENT FINDINGS: Since the inclusion of fatigue as a patient-endorsed core outcome measure in rheumatoid arthritis (RA) trials, OMERACT has been instrumental in advocating for patient involvement in the development of core domains and instruments; current endeavors include cultivating an understanding of remission through the eyes of patients and gaining a sense of how to measure features of pain and 'stiffness' deemed as important to patients...
March 2017: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/27984323/use-of-large-healthcare-databases-for-rheumatology-clinical-research
#15
Rishi J Desai, Daniel H Solomon
PURPOSE OF REVIEW: Large healthcare databases, which contain data collected during routinely delivered healthcare to patients, can serve as a valuable resource for generating actionable evidence to assist medical and healthcare policy decision-making. In this review, we summarize use of large healthcare databases in rheumatology clinical research. RECENT FINDINGS: Large healthcare data are critical to evaluate medication safety and effectiveness in patients with rheumatologic conditions...
March 2017: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/27977623/the-contribution-of-autoantibodies-to-post-translationally-modified-proteins-to-inflammatory-arthritis
#16
Diane van der Woude, René E M Toes
PURPOSE OF REVIEW: This article provides an overview of the recent findings present in the field of antimodified protein antibodies and their relevance for rheumatic disease, with a focus on rheumatoid arthritis. RECENT FINDINGS: Next to anticitrullinated protein antibodies, also other antimodified protein antibodies such as anticarbamylated protein antibodies or antiacetylated protein antibodies are emerging. Likewise, their possible pathological contributions are getting detailed attention...
March 2017: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/27941392/a-new-era-of-quality-measurement-in-rheumatology-electronic-clinical-quality-measures-and-national-registries
#17
Chris Tonner, Gabriela Schmajuk, Jinoos Yazdany
PURPOSE OF REVIEW: This article reviews the evolution of quality measurement in rheumatology, highlighting new health-information technology infrastructure and standards that are enabling unprecedented innovation in this field. RECENT FINDINGS: Spurred by landmark legislation that ties physician payment to value, the widespread use of electronic health records, and standards such as the Quality Data Model, quality measurement in rheumatology is rapidly evolving...
March 2017: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/27941391/mechanobiological-implications-of-articular-cartilage-crystals
#18
Alyssa K Carlson, Carley N McCutchen, Ronald K June
PURPOSE OF REVIEW: Calcium crystals exist in both pathological and normal articular cartilage. The prevalence of these crystals dramatically increases with age, and crystals are typically found in osteoarthritic cartilage and synovial fluid. Relatively few studies have examined the effects of crystals on cartilage biomechanics or chondrocyte mechanotransduction. The purpose of this review is to describe how crystals could influence cartilage biomechanics and mechanotransduction in osteoarthritis...
March 2017: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/27941390/mesenchymal-stem-cells-for-the-management-of-rheumatoid-arthritis-immune-modulation-repair-or-both
#19
Sharon Ansboro, Anke J Roelofs, Cosimo De Bari
PURPOSE OF REVIEW: Mesenchymal stromal/stem cells (MSCs) have potent anti-inflammatory and immunomodulatory properties, in addition to their ability to form cartilage and bone. The purpose of this review is to highlight recent developments and current knowledge gaps in our understanding of the protective effects of MSCs against inflammatory arthritis, and to discuss their clinical exploitation for the treatment of rheumatoid arthritis (RA). RECENT FINDINGS: The weight of evidence for protective mechanisms of exogenously administered MSCs is on immunomodulatory effects, including inhibition of dendritic cell maturation, polarization of macrophages to an anti-inflammatory phenotype, and activation of regulatory T cells, thereby dampening inflammation and preventing joint damage...
March 2017: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/27941389/factors-modulating-the-inflammatory-response-in-acute-gouty-arthritis
#20
Maartje C Cleophas, Tania O Crişan, Leo A B Joosten
PURPOSE OF REVIEW: Gout is a common debilitating form of arthritis and despite our extensive knowledge on the pathogenesis its prevalence is still rising quickly. In the current review, we provide a concise overview of recent discoveries in factors tuning the inflammatory response to soluble uric acid and monosodium urate crystals. RECENT FINDINGS: It appears that soluble uric acid has a much larger role to play than just being a risk factor for gout. It may have widespread consequences for systemic inflammation and the development of metabolic syndrome...
March 2017: Current Opinion in Rheumatology
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