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Current Opinion in Rheumatology

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https://www.readbyqxmd.com/read/29702496/quantifying-the-genetic-risk-for-the-development-of-axial-spondyloarthropathy-could-this-become-a-diagnostic-tool
#1
Bryan P Wordsworth, Carla J Cohen, Matteo Vecellio
PURPOSE OF REVIEW: To assess the utility of recent genetic findings in ankylosing spondylitis (AS) and axial spondyloarthropathy (SpA) in relation to diagnostic testing, prognosis and responses to biologic treatment and the development of new therapies. RECENT FINDINGS: AS and other forms of SpA are polygenic with more than 100 genes contributing to disease susceptibility. The role of genes in determining the outcome of the disease and response to treatment is less clear...
April 26, 2018: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/29697434/evolution-of-clinical-trials-for-rheumatoid-arthritis-and-spondyloarthritis
#2
Marleen G H van de Sande, Ronald F van Vollenhoven
PURPOSE OF REVIEW: The present review presents an overview of the evolution in trial design from mainly randomized placebo-controlled efficacy trials to more strategic clinical trials in rheumatoid arthritis and spondyloarthritis. Additionally, it relates to how these differently designed trials have affected clinical practice. RECENT FINDINGS: Placebo-controlled clinical trials, comparing a new agent to placebo on a stable background, have resulted in the development of a wide array of therapeutic agents in rheumatoid arthritis and spondyloarthritis...
April 24, 2018: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/29664755/advances-in-spondyloarthritis-glimpse-in-the-future
#3
Atul Deodhar
No abstract text is available yet for this article.
April 16, 2018: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/29664757/primary-hyperparathyroidism-recent-advances
#4
Marcella D Walker, John P Bilezikian
PURPOSE OF REVIEW: The purpose of this review is to describe recent advances and changes in the evaluation and management of primary hyperparathyroidism (PHPT). RECENT FINDINGS: Although it has long been recognized that asymptomatic PHPT is associated with bone loss, particularly at cortical skeletal sites when evaluated with dual-energy X-ray absorptiometry, new imaging techniques suggest that trabecular skeletal deterioration as well as clinically silent vertebral fractures and nephrolithiasis are common...
April 13, 2018: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/29664756/mri-in-spondyloarthritis-when-and-how
#5
Georg Kröber, Ulrich Weber
PURPOSE OF REVIEW: To summarize recent advances and challenges of using MRI toward early recognition of axial spondyloarthritis (SpA). RECENT FINDINGS: Low-grade bone marrow edema (BME) on sacroiliac joint (SIJ) MRI is nonspecific and may be misleading in recognition of axial SpA. Structural features on SIJ MRI along with BME may not only facilitate recognition of early disease, but also enhance specificity. Structural lesions on MRI and low-dose computed tomography are highly concordant, adding to criterion validity of SIJ MRI...
April 13, 2018: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/29634582/infections-and-autoimmunity-new-insights-into-an-age-old-reciprocity
#6
Yahel Segal, Daniel Zohar, Yehuda Shoenfeld
No abstract text is available yet for this article.
April 9, 2018: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/29634581/fracture-prediction-and-prevention-will-newer-technologies-help
#7
Gregory Chang, Stephen Honig
No abstract text is available yet for this article.
April 9, 2018: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/29634580/complementary-medicine-for-axial-spondyloarthritis-is-there-any-scientific-evidence
#8
Abhijeet Danve, Atul Deodhar
PURPOSE OF REVIEW: Majority of patients with axial spondyloarthritis (axSpA) report use of complementary and alternative medicine (CAM) therapies before and even after the diagnosis, due to perceived efficacy and wide-spread belief that these modalities lack side effects. In this review, we describe the available scientific evidence for the CAM therapies in axSpA. RECENT FINDINGS: Clinical trials of the CAM therapies in axSpA are generally hampered by small sample size, short duration, difficulties in blinding, lack of control groups and strong placebo effect...
April 9, 2018: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/29621030/long-term-treatment-strategies-for-postmenopausal-osteoporosis
#9
Felicia Cosman
PURPOSE OF REVIEW: Osteoporosis guidelines do not usually provide specific recommendations regarding what medication is most appropriate for individual patients. Generic oral bisphosphonates are often considered first-line treatment for osteoporosis, but treatment duration is limited, based on potential long-term safety concerns, and there is no consensus about what to do after 5 years. There are no recommendations concerning long-term management of osteoporosis over 30 or more years of postmenopausal life...
April 4, 2018: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/29621029/trimethoprim-sulfamethoxazole-and-antineutrophil-cytoplasmic-antibodies-associated-vasculitis
#10
Jan Willem Cohen Tervaert
PURPOSE OF REVIEW: In antineutrophil cytoplasmic antibodies-associated vasculitis (AAV), the treatment of choice is either Rituximab or cyclophosphamide in combination with steroids. In less extended forms of AAV, however, less toxic regimens are being used.In the current review, we will focus on the role of one of these less toxic regimens, that is trimethoprim-sulfamethoxazole monotherapy as induction treatment or as maintenance therapy in AAV. RECENT FINDINGS: A substantial portion of patients with active granulomatosis with polyangiitis (GPA) limited to the upper airways can be initially controlled with trimethoprim-sulfamethoxazole (2 × 960 mg/day) monotherapy...
April 4, 2018: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/29538012/multiple-hit-infection-and-autoimmunity-the-dysbiotic-microbiota-acpa-connection-in-rheumatoid-arthritis
#11
Lazaros I Sakkas, Dimitrios P Bogdanos
PURPOSE OF REVIEW: This review highlights the most recent data obtained in this field and provides clues toward the better understanding of the close interplay between microbiota and host, leading to autoimmune diseases. RECENT FINDINGS: A well-described model of microbiota/host interaction of relevance to autoimmunity is that linking anti-citrullinated peptide antibody positive rheumatoid arthritis and alterations of microbiota largely concentrating on Porphyromonas gingivalis and more recently of Aggregatibacter actinomycetemcomitans and Prevotella copri...
March 13, 2018: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/29538011/computed-tomography-in-axial-spondyloarthritis
#12
Sovira Tan, Michael M Ward
PURPOSE OF REVIEW: Computed tomography (CT) is increasingly being used in ankylosing spondylitis (AS) for imaging the spine and sacroiliac joint (SIJ). We review new insights to diagnosis and evaluation revealed by the use of CT. RECENT FINDINGS: Studies using low-dose CT in AS to detect syndesmophytes can image the entire spine, but semiquantitative scoring of the scans by human readers decreases the reliability and validity of this method. The thoracic spine is the segment most involved with syndesmophytes...
March 13, 2018: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/29538010/fecal-transplants-in-spondyloarthritis-and-uveitis-ready-for-a-clinical-trial
#13
Rene Y Choi, Mark Asquith, James T Rosenbaum
PURPOSE OF REVIEW: The intestinal microbiome is thought to play a role in the pathogenesis of inflammatory bowel disease (IBD). There are many shared clinical manifestations between IBD and spondyloarthritis (SpA), of which the most common are peripheral arthritis and uveitis. Clinical overlap along with similar genetics between these diseases suggests a possible shared pathogenetic mechanism, which might center on the intestinal microbiota. In this review, we discuss the available evidence that SpA is a microbiome-driven disease and indicate how SpA-associated uveitis could be tied to gut dysbiosis...
March 13, 2018: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/29528866/the-utility-and-limitations-of-using-trabecular-bone-score-with-frax
#14
Patrick Martineau, William D Leslie
PURPOSE OF REVIEW: Trabecular bone score (TBS) is a texture index derived from the lumbar spine dual-energy X-ray absorptiometry which can assess skeletal quality and provide information about fracture risk independent of bone mineral density (BMD). TBS is useful in assessing osteoporotic fracture risk, with lower TBS values associated with increased fracture risk. In this article, we review the current state of TBS, including its utility and limitations in the assessment and management of osteoporosis, with particular emphasis on the recent literature...
March 9, 2018: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/29528865/autoimmune-manifestations-of-infections
#15
Luis J Jara, Gabriela Medina, Miguel A Saavedra
PURPOSE OF REVIEW: To provide an update about the interactions between infections and autoimmune diseases (AIDs), from the molecular perspective to the clinical spectrum and the differentiation between infection and disease activity. RECENT FINDINGS: Any kind of infection may modify the innate and adaptive immune response through the following mechanisms: molecular mimicry, superantigens, epitope spreading and B-cell activation. The consequence is the overproduction of antibodies shared with those found in AIDs...
March 9, 2018: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/29432224/extra-pulmonary-diseases-related-to-mycoplasma-pneumoniae-in-children-recent-insights-into-the-pathogenesis
#16
Dimitri Poddighe
PURPOSE OF REVIEW: Providing an overview on Mycoplasma pneumoniae-related extra-pulmonary diseases (MpEPDs) in children, who represent the preferred target population by those complications, and discussing the main pathogenic mechanisms implicated or potentially involved. RECENT FINDINGS: Recent evidences supported the fact that M. pneumoniae is more than an extra-cellular pathogen colonizing epithelial cells of the respiratory tract. It is able to penetrate the cell membrane of host cells and to invade the respiratory mucosa, leading to pronounced inflammatory responses and also spreading outside the respiratory system, to some extent...
March 3, 2018: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/29538009/mycophenolate-mofetil-for-rheumatic-diseases-should-we-monitor-the-area-under-the-curve
#17
William J McCune, Mousa Al Abbas
No abstract text is available yet for this article.
May 2018: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/29517495/hydroxychloroquine-balancing-the-need-to-maintain-therapeutic-levels-with-ocular-safety-an-update
#18
Nada Abdulaziz, Anjali R Shah, William J McCune
PURPOSE OF REVIEW: Antimalarial drugs including chloroquine, its less toxic quinolone-derivative hydroxychloroquine (HCQ), and quinacrine have become cornerstones in the treatment of autoimmune diseases including systemic lupus, rheumatoid arthritis, sarcoidosis, and Sjogren syndrome; cutaneous disorders, antiphospholipid syndrome, and have recently been employed at higher dioses in oncology. Benefits include anti-inflammatory effects, protection against thrombosis, and improved control of hyperglycemia and hyperlipidemia...
May 2018: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/29465468/getting-personal-towards-individualized-management-of-rheumatoid-arthritis
#19
Jon T Giles
No abstract text is available yet for this article.
May 2018: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/29461286/recent-advances-in-the-treatment-of-rheumatoid-arthritis
#20
Tina D Mahajan, Ted R Mikuls
PURPOSE OF REVIEW: Therapies for rheumatoid arthritis (RA) continue to expand rapidly. The purpose of this review is to discuss novel treatment options, including biosimilars, that are available, as well as to highlight promising agents in development. The purpose is also to discuss new emerging safety signals associated with these drugs and to discuss strategies in tapering therapy. RECENT FINDINGS: There are several novel RA therapies. These include the interleukin-6 (IL-6) receptor blocker sarilumab, which was approved in 2017...
May 2018: Current Opinion in Rheumatology
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