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Growth Factors

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https://www.readbyqxmd.com/read/28415893/rem-sleep-deprivation-impairs-muscle-regeneration-in-rats
#1
Marcos Mônico-Neto, Murilo Dáttilo, Daniel Araki Ribeiro, Kil Sun Lee, Marco Túlio de Mello, Sergio Tufik, Hanna Karen Moreira Antunes
INTRODUCTION: The aim was observe the influence of sleep deprivation (SD) and sleep recovery on muscle regeneration process in rats submitted to cryolesion. METHODS: Thirty-two Wistar rats were randomly allocated in four groups: control (CTL), SD for 96 h (SD96), control plus sleep recovery period (CTL + R) and SD96h plus 96 h of sleep recovery (SD96 + R). The animals were submitted to muscle injury by cryolesioning, after to SD and sleep recovery. RESULTS: The major outcomes of this study were the reduction of muscular IGF-1 in both legs (injured and uninjured) and a delay in muscle regeneration process of animals submitted to SD compared to animals that slept, with increase connective tissue, inflammatory infiltrate and minor muscle fibers...
April 17, 2017: Growth Factors
https://www.readbyqxmd.com/read/28264596/prolonged-intra-myocardial-growth-hormone-administration-ameliorates-post-infarction-electrophysiologic-remodeling-in-rats
#2
Marianthi Kontonika, Eleonora Barka, Maria Roumpi, Vassilios La Rocca, Panagiotis Lekkas, Evangelos P Daskalopoulos, Agapi D Vilaeti, Giannis G Baltogiannis, Antonios P Vlahos, Simeon Agathopoulos, Theofilos M Kolettis
Experimental studies indicate improved ventricular function after treatment with growth hormone (GH) post-myocardial infarction, but its effect on arrhythmogenesis is unknown. Here, we assessed the medium-term electrophysiologic remodeling after intra-myocardial GH administration in (n = 33) rats. GH was released from an alginate scaffold, injected around the ischemic myocardium after coronary ligation. Two weeks thereafter, ventricular tachyarrhythmias were induced by programmed electrical stimulation...
March 6, 2017: Growth Factors
https://www.readbyqxmd.com/read/28122472/human-placental-growth-hormone-is-increased-in-maternal-serum-at-20-weeks-of-gestation-in-pregnancies-with-large-for-gestational-age-babies
#3
Shutan Liao, Mark H Vickers, Rennae S Taylor, Beatrix Jones, Mhoyra Fraser, Lesley M E McCowan, Philip N Baker, Jo K Perry
To investigate the relationship between maternal serum concentrations of placental growth hormone (GH-V), insulin-like growth factor (IGF)-1 and 2, IGF binding proteins (IGFBP)-1 and 3 and birth weight in appropriate-for-gestational-age (AGA), large-for-gestational-age (LGA) and small-for-gestational-age (SGA) cases in a nested case-control study. Maternal serum samples were selected from the Screening for Pregnancy Endpoints (SCOPE) biobank in Auckland, New Zealand. Serum hormone concentrations were determined by ELISA...
January 25, 2017: Growth Factors
https://www.readbyqxmd.com/read/28095739/expression-and-localization-of-fibroblast-growth-factor-fgf-23-and-klotho-in-the-spleen-its-physiological-and-functional-implications
#4
Yuri Nakashima, Toru Mima, Mitsuru Yashiro, Tomohiro Sonou, Masaki Ohya, Asuka Masumoto, Shintaro Yamanaka, Daisuke Koreeda, Koichi Tatsuta, Yoshiyuki Hanba, Mari Moribata, Shigeo Negi, Takashi Shigematsu
The FGF23-Klotho signaling axis is known to exert anti-aging effects via calcium-phosphorus metabolism. In mice deficient in FGF23-Klotho signaling, however, the number of splenocytes is reduced. FGF23 is expressed in both bone and spleen, with regulation of its production differing in these organs. As FGF23-Klotho signaling may play an immunological role in the spleen, splenocytes in male C57BL/6J mice were assayed for expression of Klotho or FGF23 by flow cytometry and immunohistochemistry. Cells that expressed Klotho included CD45R/B220(+) CD21/CD35(+) CD1d(+) CD43(-) marginal zone B cells...
January 18, 2017: Growth Factors
https://www.readbyqxmd.com/read/27921577/the-efficiency-and-safety-of-trastuzumab-for-advanced-gastric-and-gastroesophageal-cancer-a-meta-analysis-of-five-randomized-controlled-trials
#5
Binghong Xiong, Li Ma, Wei Huang, Huayou Luo, Yujian Zeng, Yan Tian
A meta-analysis was performed to examine the efficiency and safety of trastuzumab in patients with advanced gastric and gastroesophageal cancer (AGC). By searching multiple databases from 1990 to March 2016, all randomized controlled trials (RCTs) which compared the effect of trastuzumab-combined chemotherapy (TC) versus chemotherapy alone (CT) in gastric cancer would be included. Five RCTs with a total of 875 patients were included. Trastuzumab can improve the overall survival (OS) rate, progression-free survival (PFS), one-year survival rate, two-year survival rate and overall response rate (ORR) of patients with AGC...
December 6, 2016: Growth Factors
https://www.readbyqxmd.com/read/28209092/fibroblast-growth-factor-1-fgf-1-promotes-adipogenesis-by-downregulation-of-carboxypeptidase-a4-cpa4-a-negative-regulator-of-adipogenesis-implicated-in-the-modulation-of-local-and-systemic-insulin-sensitivity
#6
Jingjing He, Daniel L Chen, Dorit Samocha-Bonet, Kevin R Gillinder, Johanna L Barclay, Graham W Magor, Andrew C Perkins, Jerry R Greenfield, Gongshe Yang, Jonathan P Whitehead
Fibroblast growth factor-1 (FGF-1) promotes differentiation of human preadipocytes into mature adipocytes via modulation of a BMP and Activin Membrane-Bound Inhibitor (BAMBI)/Peroxisome proliferator-activated receptor (PPARγ)-dependent network. Here, we combined transcriptomic and functional investigations to identify novel downstream effectors aligned with complementary analyses of gene expression in human adipose tissue to explore relationships with insulin sensitivity. RNA-Seq and qRT-PCR analysis revealed significant down-regulation of carboxypeptidase A4 (CPA4) following FGF-1 treatment or induction of differentiation of human preadipocytes in a BAMBI/PPARγ-independent manner...
December 2016: Growth Factors
https://www.readbyqxmd.com/read/28209091/hgf-induced-dna-synthesis-in-hepatocytes-is-suppressed-by-p38
#7
Monica Aasrum, Ingvild J Brusevold, Thoralf Christoffersen, G Hege Thoresen
Previous studies in rat hepatocytes have shown that the MEK/ERK, PI3K/Akt and p38 pathways are all involved in the activation of DNA synthesis by EGF and that sustained activation of MEK/ERK is required. Here, we show that although HGF stimulated DNA synthesis and activated signaling in the same manner as EGF, the contribution of the signaling pathways to the induction of DNA synthesis differed. While HGF-induced DNA synthesis was dependent on MEK/ERK, with no significant contribution from PI3K/Akt, p38 suppressed HGF-induced DNA synthesis...
December 2016: Growth Factors
https://www.readbyqxmd.com/read/27776448/platelet-derived-growth-factor-bb-attenuates-titanium-particle-induced-osteolysis-in-vivo
#8
Chenyi Ye, Wei Zhang, Shuai Jiang, Yuanbin Yu, Xiaoyu Zhou, Ling Zhu, Deting Xue, Rongxin He
Inflammation and osteoclastogenesis play critical roles in wear-particle-induced periprosthetic osteolysis (WPO). Platelet-derived growth factor-BB (PDGF-BB) could promote osteogenesis and inhibit inflammatory response. The aim of this study was to investigate the impact of PDGF-BB on WPO. Mice were divided into four groups, namely, sham, vehicle, low-, and high-dose PDGF-BB groups. Mice in the rhPDGF-BB groups were treated with PDGF-BB at 0.25 or 1 mg/ml/kg/day. Mice in the sham and vehicle groups received PBS daily...
October 24, 2016: Growth Factors
https://www.readbyqxmd.com/read/27760485/leukemia-inhibitory-factor-stimulates-steroidogenesis-of-rat-immature-leydig-cells-via-increasing-the-expression-of-steroidogenic-acute-regulatory-protein
#9
Yiyan Wang, Kaiming Yuan, Xiaoheng Li, Zhijian Su, Xingwang Li, Hongguo Guan, Ying Su, Hong-Shan Ge, Ren-Shan Ge
Leukemia inhibitory factor (LIF) has many physiological roles. However, its effects on Leydig cell development are still unclear. Rat immature and adult Leydig cells were cultured with different concentrations of LIF alone or in combination with luteinizing hormone (LH) for 24 h. LIF (1 and 10 ng/ml) significantly increased androgen production in immature Leydig cells, but had no effects on testosterone production in adult Leydig cells. Further studies revealed that LIF dose-dependently increased Star and Hsd17b3 expression levels in immature Leydig cells...
October 19, 2016: Growth Factors
https://www.readbyqxmd.com/read/27681688/dysregulation-of-calcium-channels-decreases-parasecretion-in-pancreatic-%C3%AE-cells-in-rats-born-small-for-gestational-age
#10
Yan-Yan Jin, Meng-Zao He, Zhen-Yong Wu, Ke Huang, Ying Shen, Li Liang, Jian-Hua Mao
OBJECTIVE: To investigate the role of intrauterine malnourishment in the development and function of pancreatic islet β-cells. METHODS: Whole-cell patch clamping was used to record voltage-gated calcium channel (VGCC)-mediated currents. Insulin secretion was detected by measuring capacitance using a sequence of sine wave stimuli. VGCC currents and insulin secretion were measured in the small for gestational age (SGA) group treated with human recombinant growth hormone (hGH)...
September 29, 2016: Growth Factors
https://www.readbyqxmd.com/read/27686612/plasma-ctgf-is-independently-related-to-an-increased-risk-of-cardiovascular-events-and-mortality-in-patients-with-atherosclerotic-disease-the-smart-study
#11
Karin G Gerritsen, Lucas L Falke, Stefan H van Vuuren, Jan W Leeuwis, Roel Broekhuizen, Tri Q Nguyen, Gert Jan de Borst, Hendrik M Nathoe, Marianne C Verhaar, Robbert J Kok, Roel Goldschmeding, Frank L Visseren
AIMS: Connective tissue growth factor (CTGF) plays a key role in tissue fibrogenesis and growing evidence indicates a pathogenic role in cardiovascular disease. Aim of this study is to investigate the association of connective tissue growth factor (CTGF/CCN2) with cardiovascular risk and mortality in patients with manifest vascular disease. METHODS AND RESULTS: Plasma CTGF was measured by ELISA in a prospective cohort study of 1227 patients with manifest vascular disease (mean age 59...
August 2016: Growth Factors
https://www.readbyqxmd.com/read/27442780/targeting-the-transforming-growth-factor-%C3%AE-signaling-during-pre-implantation-development-in-embryos-of-cattle-sheep-and-goats
#12
Mehdi Hajian, Sayyed Morteza Hosseini, Somayyeh Ostadhosseini, Mohammad Hossein Nasr-Esfahani
Recently, application of chemical inhibitors against differentiation signaling pathways has improved establishment of mESCs. In this study, we applied inhibitors of TGF-β (SB431542) and BMP4 (Noggin) from cleavage to blastocyst stage in cattle, goat and sheep embryos. SB significantly decreases blastocyst rate and total cell number (TCN) in sheep blastocysts, whereas only TCN was significantly decreased in cattle blastocysts. In contrast to SB, Noggin significantly improved cattle blastocyst development but decreased TCN...
August 2016: Growth Factors
https://www.readbyqxmd.com/read/27418111/comparative-evaluation-of-the-wound-healing-potency-of-recombinant-bfgf-and-ski-gene-therapy-in-rats
#13
Yan Peng, Ping Li, Zi-Ai Zhao, Lei Chen, Xiao-Guang Zhao, Xing Chen, Yan Zhao, Ren-Ping Xiong, Ya-Lei Ning, Nan Yang, Jian Ye, Yuan-Guo Zhou
We previously demonstrated that cellular Sloan-Kettering Institute (c-Ski) played a dual role, both promoting wound healing and alleviating scar formation. However, its mechanism and therapeutic effects are not clear, especially compared with widely used treatments, such as basic fibroblast growth factor (bFGF) administration. However, Ski treatment led to an even shorter healing time and a more significant reduction in scar area than bFGF treatment. The mechanism underlying this difference was related to a reduced inflammatory response, more rapid re-epithelialization, less collagen after healing and a greater reduction in the proportion of alpha-smooth muscle actin and SMemb-positive cells after Ski treatment...
August 2016: Growth Factors
https://www.readbyqxmd.com/read/27388576/contradicting-interplay-between-insulin-like-growth-factor-1-and-mir-486-5p-in-primary-nk-cells-and-hepatoma-cell-lines-with-a-contemporary-inhibitory-impact-on-hcc-tumor-progression
#14
Rana Ahmed Youness, Mai Atef Rahmoon, Reem Amr Assal, Asmaa Ibrahim Gomaa, Mohamed Tarif Hamza, Imam Waked, Hend Mohamed El Tayebi, Ahmed Ihab Abdelaziz
In this study, an impaired natural killer (NK) cell cytolytic activity in 135 hepatocellular carcinoma (HCC) patients parallel to a reduced expression level of insulin-like growth factor (IGF)-1 in NK cells of HCC patients has been revealed. Ectopic expression of miR-486-5p, a direct upstream regulator of IGF-1, restored the endogenous level of IGF-1 in NK cells of HCC patients, thus augmenting its cytolytic activity against Huh7 cells in an opposite manner to the IGF-1 siRNAs. Unorthodoxly, over-expression of miR-486-5p in target hepatocytes resulted in the repression of IGF-1, suppression of Huh7 cells proliferation and viability in a similar pattern to the IGF-1 siRNAs...
August 2016: Growth Factors
https://www.readbyqxmd.com/read/27366871/hypoxia-suppresses-myocardial-survival-pathway-through-hif-1%C3%AE-igfbp-3-dependent-signaling-and-enhances-cardiomyocyte-autophagic-and-apoptotic-effects-mainly-via-foxo3a-induced-bnip3-expression
#15
Chih-Chung Feng, Chien-Chung Lin, Yi-Ping Lai, Tung-Sheng Chen, Shibu Marthandam Asokan, Jing-Ying Lin, Kuan-Ho Lin, Vijaya Padma Viswanadha, Wei-Wen Kuo, Chih-Yang Huang
The HIF-1α transcriptional factor and the BH-3 only protein BNIP3 are known to play fundamental roles in response to hypoxia. The objective of this research is to investigate the molecular mechanisms and the correlation of HIF-1α, BNIP3 and IGFBP-3 in hypoxia-induced cardiomyocytes injuries. Heart-derived H9c2 cells and neonatal rat ventricular myocytes (NRVMs) were incubated in normoxic or hypoxic conditions. Hypoxia increased HIF-1α expression and activated the downstream BNIP3 and IGFBP-3 thereby triggered mitochondria-dependent apoptosis...
August 2016: Growth Factors
https://www.readbyqxmd.com/read/27362575/adipose-derived-stem-cells-sustain-prolonged-angiogenesis-through-leptin-secretion
#16
Simona Delle Monache, Alessia Calgani, Patrizia Sanità, Francesca Zazzeroni, Emilio Gentile Warschauer, Antonio Giuliani, Gianfranco Amicucci, Adriano Angelucci
Recent studies suggest that adipose-derived stem cells (ASCs) play a role in tissue remodeling through the release of cytokines and growth factors. We compared the secreted cytokine profile of hypoxia-conditioned ASCs (hASCs) with normoxic ASCs (nASCs) and we analyzed the effect of ASCs conditioned medium (CM) on endothelial cells. We found that hypoxia induced a transient upregulation of VEGF in ASCs and a notable and enduring upregulation of leptin mRNA expression 30-fold greater than control after 24 h and up to 60-fold greater than control at day 7...
August 2016: Growth Factors
https://www.readbyqxmd.com/read/27362476/restoration-of-ovarian-tissue-function-and-estrous-cycle-in-rat-after-autotransplantation-using-hyaluronic-acid-hydrogel-scaffold-containing-vegf-and-bfgf
#17
Somayeh Tavana, Mojtaba Rezazadeh Valojerdi, Mahnaz Azarnia, Abdolhossein Shahverdi
This study investigates the effect of hyaluronic acid (HA) containing VEGF and bFGF on restoration of ovarian function after ovarian autotransplantation. Twenty-four rats were randomly divided into three groups for ovarian autotransplantation: group A (ovaries without HA, VEGF and bFGF), group B (ovaries encapsulated with HA) and group C (ovaries encapsulated with HA containing VEGF and bFGF). The grafts were assessed using vaginal smears, histological, hormonal, and the genes expression analysis. The duration of first estrous cycle was shorter in group C than in group A (p < 0...
August 2016: Growth Factors
https://www.readbyqxmd.com/read/27362374/in-ovo-exposure-to-monochromatic-lights-affect-posthatch-muscle-growth-and-satellite-cell-proliferation-of-chicks-role-of-igf-1
#18
Xinjie Bai, Yao Wang, Zixu Wang, Jing Cao, Yulan Dong, Yaoxing Chen
To study the role of IGF-1 on stimulation with monochromatic light during incubation altering posthatch muscle growth, chicken embryos were exposed to blue light, green light, red light, white light or darkness throughout embryonic period and then were raised in white light conditions upon hatching. Comparing with the other treatment groups, the chicks in green light group had heavier hatching weights, higher muscle indexes and larger muscle fibers. Both in vivo and in vitro studies showed that the number and proliferative activity of satellite cells in green light group were the highest...
August 2016: Growth Factors
https://www.readbyqxmd.com/read/27351840/growth-factors-the-journey-continues
#19
Steven A Stacker
No abstract text is available yet for this article.
February 2016: Growth Factors
https://www.readbyqxmd.com/read/27170215/the-platelet-derived-growth-factors-pdgfs-and-their-receptors-pdgfrs-are-major-players-in-oncogenesis-drug-resistance-and-attractive-oncologic-targets-in-cancer
#20
Ying Wang, Kwaku Appiah-Kubi, Min Wu, Xiaoyuan Yao, Hai Qian, Yan Wu, Yongchang Chen
The platelet-derived growth factors (PDGFs) and their receptors (PDGFRs) play a key role in signaling pathways in oncogenesis. The overexpression of PDGFs and PDGFRs and the oncogenic alterations of these receptors have been implicated in human cancers and correlated significantly with poor outcomes. This review discusses the biology of the PDGF isoforms and receptors briefly, and their role in oncogenesis. Also, the attractiveness of targeting PDGFs and PDGFRs, based on a wide display of oncologic alterations in cancers, diverse therapeutic strategies, their roles in resistance to cancer treatments with prospects of overcoming drug resistance, and the extent to which validated biomarkers have been developed for effective PDGFs and PDGFRs-based cancer management are discussed...
February 2016: Growth Factors
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