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Journal of Dermatological Treatment

Justin C Chia, P Régine Mydlarski
PURPOSE: Omalizumab is a recombinant humanized monoclonal antibody that inhibits the binding of IgE to the high-affinity IgE receptor (FceRI) on the surface of mast cells and basophils. Omalizumab has been approved for use in asthma, and new reports show promise in a variety of dermatologic diseases. Herein, we review the literature on omalizumab in dermatology and discuss the safety, efficacy and mechanisms of action for this emerging therapy. MATERIALS AND METHODS: PubMED, MEDLINE, and Embase databases were searched for the period January 1, 1990, to September 1, 2016...
October 19, 2016: Journal of Dermatological Treatment
Kristian Reich, Craig Leonardi, Mark Lebwohl, Francisco Kerdel, Yukari Okubo, Ricardo Romiti, Orin Goldblum, Ellen B Dennehy, Lisa Kerr, Howard Sofen
BACKGROUND: Scalp is a frequently affected and difficult-to-treat area in psoriasis patients. OBJECTIVES: We assessed the efficacy of ixekizumab in the treatment of patients with scalp psoriasis over 60 weeks using the Psoriasis Scalp Severity Index (PSSI). METHODS: In three Phase 3, multicenter, double-blind, placebo-controlled trials, patients with moderate-to-severe psoriasis in UNCOVER-1 (N = 1296), UNCOVER-2 (N = 1224), and UNCOVER-3 (N = 1346) were randomized to subcutaneous 80 mg ixekizumab every 2 weeks (Q2W) or every 4 weeks (Q4W) after a 160 mg starting dose, or placebo through Week 12...
October 19, 2016: Journal of Dermatological Treatment
Alessandra Haskin, Shawn G Kwatra, Crystal Aguh
Acquired trichorrhexis nodosa is a common cause of hair loss for patients of all ethnicities. It is especially prevalent in black patients with tightly curled hair types and can present unique diagnostic and therapeutic challenges due to structural differences in these hair types and the combination of various hair care and styling practices that contribute to hair damage. While scalp biopsies can help rule out other etiologies of hair loss, there is a paucity of histologic findings in acquired trichorrhexis nodosa, making this primarily a clinical diagnosis...
October 10, 2016: Journal of Dermatological Treatment
Ali Balevi, Pelin Üstüner, Mustafa Özdemir
BACKGROUND: Recalcitrant facial verruca plana (FVP) may persist for years and full remission is not always achieved with conventional therapies. The clinical success rates reported for different lasers are highly variable and only one study evaluated the Er:YAG laser for the treatment of FVP. OBJECTIVE: To determine whether Er:YAG is safe and effective for the treatment of recalcitrant FVP. METHODS: Forty-six patients with recalcitrant FVP were treated by Er:YAG at four-week intervals...
October 3, 2016: Journal of Dermatological Treatment
Diamant Thaçi, Matthias Augustin, Bernd Westermayer, Anja Kamps, Michael Hennig
PURPOSE: Severe chronic hand eczema (CHE) has a debilitating effect on quality of life (QoL). PASSION evaluated the effectiveness of oral alitretinoin on QoL and work productivity in patients with severe CHE following prescribing guidelines. METHODS: A non-interventional, open-label, observational, multicentre study conducted in Germany in fulfilment of German guidelines. Patients (n = 631) were treated with once-daily alitretinoin for ≤24 weeks under standard daily practise conditions...
October 3, 2016: Journal of Dermatological Treatment
Alice He, Divya Sharma, Kazuki M Matsuda, Shawn G Kwatra
Chronic itch is a debilitating symptom that significant decreases patients' quality of life. Topical corticosteroids and antihistamines are commonly used for itch. However, these therapies are not long-term solutions for chronic pruritus because of their feared side effects, including skin atrophy and cognitive impairment, respectively. As such, dermatologists require additional therapies for long-term management of chronic pruritus. Topical anesthetics have been shown in many studies to be effective antipruritic agents...
September 30, 2016: Journal of Dermatological Treatment
Eleanor Higgins, Nicola Ralph, Sheila Ryan, Nicola Koik, Bahman Honari, Aoife Lally, Paul Collins
This study compared two dose-escalation regimens using the 308 nm excimer laser treating localised plaque psoriasis, to determine the optimal regimen. A randomised, left-right body trial was designed including patients aged >18 years with localised plaque psoriasis (<10% body surface area). The standard/low dose regimen started at 70% of the minimal erythema dose (MED), with 20% dose increments. The medium dose regimen commenced at 200% MED, with 25% increments. Patients were treated until disease clearance or a maximum of 36 treatments...
September 29, 2016: Journal of Dermatological Treatment
Toral S Vaidya, Ali Alikhan
INTRODUCTION: Treatment goals depend on individual definitions of "treatment success" and tend to differ between patients and physicians. Patients who do not meet their own treatment goals, but do meet provider definitions of well-controlled disease, may be inappropriately placed on stable treatment regimens. METHODS: Patients with psoriasis on stable treatment regimens were queried about perceptions of disease control, improvement level, overall treatment satisfaction, and consideration for trying new treatments...
September 27, 2016: Journal of Dermatological Treatment
Tian Hao Zhu, Mio Nakamura, Benjamin Farahnik, Michael Abrouk, Jason Reichenberg, Tina Bhutani, John Koo
Individuals with obsessive-compulsive features frequently visit dermatologists for complaints of the skin, hair, or nails, and often progress towards a chronic relapsing course due to the challenge associated with accurate diagnosis and management of their psychiatric symptoms. The current DSM-5 formally recognizes body dysmorphic disorder, trichotillomania, neurotic excoriation, and body focused repetitive behavior disorder as psychodermatological disorders belonging to the category of Obsessive Compulsive and Related Disorders...
September 23, 2016: Journal of Dermatological Treatment
Ming Bai, Yan Yu, Chen Huang, Yirong Liu, Meilan Zhou, Yangping Li, Feng Ma, Rui Jing, Lijuan Zhao, Li Li, Pengbo Wang, Lijie He, Shiren Sun
PURPOSES: The current treatments of toxic epidermal necrolysis (TEN) are limited to the discontinuation of a suspect medication and supportive measures. We conducted a retrospective study to evaluate the efficacy of adding continuous venovenous hemofiltration (CVVH) and hemoperfusion (HP) to the conventional treatment for TEN. METHODS: TEN patients who were admitted to our center between January 2008 and May 2016 were considered as candidates. The included patients were divided into the CVVH&HP group (n = 34) and the conventional group (n = 34) according to their accepted therapies during hospital stay...
September 21, 2016: Journal of Dermatological Treatment
Yu Xiang, Xing Wu, Chuanjian Lu, Kaiyi Wang
Psoriasis is a chronic, proliferative, and inflammatory skin disease which affects around 2-3% of the global population. Current pharmacotherapy is effective, however medication with safe and long-lasting therapeutic effects is needed. Acupuncture for psoriasis is widely used in China as well as other Asian countries, and is gradually becoming accepted globally. To determine the characteristics and advantages of acupuncture treatment for psoriasis, and to improve the clinical outcomes of this disease in the future, this review summarizes literature on acupuncture treatment for psoriasis published between 2009 and 2014...
September 15, 2016: Journal of Dermatological Treatment
Duriye Deniz Demirseren, Fadime Kilinc, Selma Emre, Mesut Akyol, Ahmet Metin, Akin Aktas
BACKGROUND: The purpose of our study is to find out in which weeks and in which cumulative doses the side effects emerge and to study whether or not there is a significant variance between the observed period and doses of the emergent side effects of the patients taking the daily doses of below and above 0.5 mg/kg. METHODS: Patients were started treatment with doses of 0.25-1 mg/kg isotretinoin, and a form was given to the patients to mark which probable side effects occurred in which weeks and called for weekly follow-up for the first 2 months...
September 15, 2016: Journal of Dermatological Treatment
Mio Nakamura, Kristina Lee, Rasnik Singh, Tian Hao Zhu, Benjamin Farahnik, Michael Abrouk, John Koo, Tina Bhutani
INTRODUCTION: There have been rare reports of eczema occurring as an adverse effect of anti-tumor necrosis factor-alpha (TNFα) therapy. METHODS: A literature search was conducted on PubMed for articles describing new onset or worsening of preexisting eczema during anti-TNFα therapy for the treatment of various inflammatory diseases. RESULTS: Eczema as an adverse effect of anti-TNFα therapy may occur in approximately 5-20% of patients with various Th1-mediated inflammatory diseases such as psoriasis, inflammatory arthritis and inflammatory bowel disease...
September 15, 2016: Journal of Dermatological Treatment
Alessandra Haskin, Crystal Aguh, Ginette A Okoye
INTRODUCTION: Alopecia can have a significant negative impact on patient's lives. The objective of this study is to describe some of the emotional and psychological challenges that affect women with scarring alopecia. METHODS: A qualitative study design was used with open-ended, individual interviews with 10 women with biopsy-proven scarring alopecia. Interviews were audio-taped, transcribed verbatim and analyzed thematically using ATLAS.ti analysis software. RESULTS: Four overarching major themes (with several subthemes) emerged including: the negative emotional impact of scarring alopecia, difficulties with concealing hair loss, negative experiences with diagnosis/management and the importance of support from others...
September 12, 2016: Journal of Dermatological Treatment
Hyunju Jin, Jeong-Min Kim, Gun-Wook Kim, Je-Ho Mun, Margaret Song, Hoon-Soo Kim, Hyun-Chang Ko, Moon-Bum Kim, Byung-Soo Kim
BACKGROUND: The limited efficacy of topical tacrolimus may result from insufficient frequency of application or amount applied in eczema patients. OBJECTIVE: To investigate the frequency of application and amount of use of topical tacrolimus in patients with various types of eczema. METHODS: The frequency of application and the applied amount of topical tacrolimus were assessed over 2 weeks. RESULTS: A total of 200 eczema patients completed this study...
September 2, 2016: Journal of Dermatological Treatment
Meryl H Mendelson, Jonathan A Bernstein, Susan Gabriel, Maria-Magdalena Balp, Haijun Tian, Jeffrey Vietri, Mark Lebwohl
PURPOSE: Data are lacking on the burden of chronic idiopathic urticaria (CIU) versus other dermatologic conditions. This analysis compared the burden of chronic urticaria (CU, proxy for CIU) with psoriasis. METHODS: Data from CU (N = 747) and psoriasis patients (N = 5,107) came from 2010-2012 US National Health and Wellness Surveys. Outcomes included SF-12v2/SF-36v2 mental and physical component summary scores (MCS and PCS, respectively) and other health/activity-related measures...
August 31, 2016: Journal of Dermatological Treatment
J M Carrascosa, P de la Cueva, P Herranz, J Labandeira, J Notario
BACKGROUND: Patients' perception of disease management can influence compliance to treatment and thus affect outcome. OBJECTIVE: To survey patients and physicians on their perceptions of biologic therapy for treating psoriasis in an outpatient setting. METHODS: The subjective impact of intravenous treatment of severe psoriasis on patients and physicians in the outpatient setting was determined via two surveys. RESULTS: Between September-November 2014, 24 dermatologists and 90 patients were surveyed...
August 27, 2016: Journal of Dermatological Treatment
Zeinab Abel Samad Ibrahim, Iman Hamed Elmaadawi, Basma Mourad Mohamed, Said Mohamed Abdou, Yasmina Ahmed El Attar, Amira Youssef, Maha Mostafa Shamloula, Atef Taha, Hala Gabr Metwally, Mohamed M El Afandy, Mohamed Labib Salem
BACKGROUND: Management of alopecia areata and androgenetic alopecia is often challenging as patients may be resistant to currently available modalities of treatment. The use of stem cells may be a novel option for resistant cases. OBJECTIVE: To evaluate the safety and efficacy of the use of autologous bone marrow derived mononuclear cells (including stem cells) as compared to follicular stems cells for the management of resistant cases of alopecia areata and androgenetic alopecia...
August 24, 2016: Journal of Dermatological Treatment
A Campanati, E Molinelli, G Ganzetti, K Giuliodori, I Minetti, M Taus, M Catani, E Martina, L Conocchiari, A Offidani
OBJECTIVE: TNF alpha inhibitors are usually associated with anthropometric changes over the time, however whether and how the visceral adipose tissue (VAT) is involved in this phenomenon, still remains unclear. Aim of the study is to evaluate if the increases in trunk fat percentage (TF%) and VAT are directly involved in anthropometric changes occurring during treatment, and whether and how a calorie restricted diet could prevent these changes. MATERIAL AND METHODS: Twenty patients receiving TNF-alpha inhibitors for psoriasis was evaluated at baseline (T0) and after 24 weeks of therapy (T24), and then compared with 25 patients receiving a combined treatment based on TNF alpha inhibitors and low-carbohydrates calorie-restricted diet...
August 23, 2016: Journal of Dermatological Treatment
J L Thijs, B A M van der Geest, J van der Schaft, M P van den Broek, W O van Seggelen, C A F Bruijnzeel-Koomen, D J Hijnen, R H van Schaik, M S de Bruin-Weller
Atopic dermatitis (AD) is a very common chronic inflammatory skin disease requiring long-term treatment. Mycophenolic acid (MPA) is used off-label in treatment of patients with severe AD failing Cyclosporin A treatment, however clinical efficacy is observed in only half of the AD patients. In blood, MPA levels are known to have a large interindividual variability. Low MPA exposure and increased enzyme activity correlates with the presence of UGT1A9 polymorphisms. In this retrospective study, 65 adult AD patients treated with MPA were classified as responder or non-responder to MPA treatment...
August 23, 2016: Journal of Dermatological Treatment
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