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Journal of Dermatological Treatment

Nasrin Saki, Mohammad Darayesh, Alireza Heiran
INTRODUCTION: Melasma is a benign, acquired, and chronic hypermelanosis. Topical hydroquinone (HQ) is a conventional choice to treat melasma. Tranexamic acid (TA) is a relatively new brightening agent that interferes with keratinocyte- melanocyte interactions. The aim of the present study was to compare the efficacy and safety of TA intradermal injections with HQ in treating melasma. MATERIALS AND METHODS: In this split-face controlled trial, thirty-seven patients were randomized to receive three monthly sessions of TA intradermal injections either on the right or the left side of their face, and topical HQ once a night for three months on the other side...
October 13, 2017: Journal of Dermatological Treatment
Ali Balevi, Pelin Üstüner, Sümeyye A Kakşi, Mustafa Özdemir
Purpose In the previous studies positive effect of sunlight on seborrhoeic dermatitis may well be explained by the direct influence of UV-light on the yeasts. Narrow-band Ultraviolet-B phototherapy appears to be a very effective and safe treatment option for patients with severe seborrhoeic dermatitis. We aimed to investigate the efficacy of narrow-band Ultraviolet-B phototherapy as an alternative treatment for pityriasis versicolor. Material and methods A total of 38 patients diagnosed with disseminated pityriasis versicolor having more than four relapsing episodes within 12 months were treated with narrow-band Ultraviolet-B phototherapy given three times weekly...
October 6, 2017: Journal of Dermatological Treatment
Lluís Puig, Jaume Notario, Alberto Jiménez-Morales, David Moreno-Ramírez, Anna López-Ferrer, Irmina Gozalbo, Míriam Prades, Luis Lizán, Carles Blanch
OBJECTIVE: To compare the cost consequence of biologic drugs for moderate-to-severe psoriasis from the perspective of the Spanish National Health System. METHODS: We built a decision tree with a two-year time horizon. Efficacy data for biologics (etanercept, infliximab, adalimumab, ustekinumab and secukinumab) were drawn from published meta-analyses: PASI75 for the induction phase and PASI90 for the rest of follow-up. Patients with PASI < 75 at week 10-16 were switched to another biologic agent...
October 5, 2017: Journal of Dermatological Treatment
P Theut Riis, D M Saunte, V Sigsgaard, C Wilken, G Jemec
BACKGROUND: HS is a debilitating chronic skin disease of the hair follicle. Intense pulsed light therapy has been suggested for treatment of HS. In this letter we report a retrospective chart review of the Hidradenitis Suppurativa patients we have treated so far. MATERIAL AND METHOD: Twenty-five patients were treated with the Palomar LuxY IPL. Patients were treated with a pulse width of either 20 or 100 nm, using a fluence between 18 and 34 J/cm(2) depending on the area treated, pain response and skin type...
October 3, 2017: Journal of Dermatological Treatment
Tiffany Alexander, Elena Maxim, Leah A Cardwell, Aneesh Chawla, Steven R Feldman
INTRODUCTION: Atopic dermatitis (AD) is a common, chronic inflammatory skin disease characterized by pruritic, often lichenified, patches and plaques. METHODS: Data were obtained from the Humana database, a large claim-based database encompassing more than 20 million patients under a commercial healthcare insurance plan. Our cohort included 39,526 subjects who saw a dermatologist for a primary ICD-9 diagnosis of atopic dermatitis (691.8) between the years of 2010 and 2015...
October 2, 2017: Journal of Dermatological Treatment
Mina Amin, Daniel J No, Jashin J Wu
BACKGROUND: Patient registries are databases comprised of standardized clinical data for a specific population of patients with a particular disease or medical condition. Information from patient registries allows clinicians to assess long-lasting outcomes in patients with a specific disease, such as psoriasis. OBJECTIVE: Our primary objective was to identify available psoriasis registries in the United States (U.S.) and evaluate the application of patient registries compared to clinical trials...
October 2, 2017: Journal of Dermatological Treatment
Rosa Ortega Del Olmo, Rafael Salido-Vallejo
INTRODUCTION: The aim of the study was to evaluate the results on effectiveness and safety of topical treatment for Actinic Keratosis (AK) with Ingenol Mebutate Gel (IMG) in real-life conditions and to perform an analysis of the factors that may influence the treatment outcomes. MATERIALS AND METHODS: Retrospective study of patients with non-hyperkeratotic AK lesions prescribed with IMG in Spain according to clinical practice. Dermatologists reported the characteristics of patients and AK at baseline, and the findings observed up to 60 days after treatment...
September 28, 2017: Journal of Dermatological Treatment
Afsaneh Alavi, R Gary Sibbald, Robert S Kirsner
No abstract text is available yet for this article.
September 27, 2017: Journal of Dermatological Treatment
F M Garritsen, J van der Schaft, C A F Bruijnzeel-Koomen, R H van Schaik, M de Graaf, M P H van den Broek, M S de Bruin-Weller
BACKGROUND: Azathioprine is frequently used in severe eczema. It is converted in the liver into active metabolites, including 6-thioguanine nucleotide (6-TGN) and methylated 6-methylmercaptopurine (6-MMP). In the past, the therapeutic potential of azathioprine may have not been fully utilized. Recent investigations on inflammatory bowel disease have led to a better understanding of azathioprine metabolism and optimizing treatment. OBJECTIVE: To investigate whether measuring thiopurine metabolites in circulation can improve the effectiveness and safety of azathioprine treatment in patients with atopic dermatitis and/or chronic hand/foot eczema...
September 26, 2017: Journal of Dermatological Treatment
Sahil Sekhon, Caleb Jeon, Mio Nakamura, Ladan Afifi, Di Yan, Jashin Wu, Wilson Liao, Tina Bhutani
PURPOSE: Crude coal tar and its derivatives have been used in modern medicine for the treatment of psoriasis since at least 1925 as part of the Goeckerman regimen. To this day, coal tar remains a safe and highly effective option for the treatment of psoriasis vulgaris. However, the mechanism by which coal tar has its therapeutic effect is unknown. This review summarizes current knowledge of the mechanism by which coal tar has its therapeutic effect in the treatment of psoriasis vulgaris...
September 19, 2017: Journal of Dermatological Treatment
Stefano Veraldi, Rossana Schianchi, Paolo Pontini, Alberto Gorani
BACKGROUND: Tinea corporis is a common mycotic infection in children. Staphylococcus aureus superinfections may be observed in atopic children with tinea corporis suffering from severe pruritus and consequent scratching. OBJECTIVE: From 2006 to 2011, we observed 288 children with mycologically proven tinea corporis. In 39 of them (13.5%) tinea corporis was superinfected by S. aureus: all these children were affected by atopic dermatitis. We interpreted these bacterial superinfections as the clinical result of scratching due to pruritus...
September 19, 2017: Journal of Dermatological Treatment
Ronald Prussick, Jashin J Wu, April W Armstrong, Michael P Siegel, Abby S Van Voorhees
BACKGROUND: Treatment of solid organ-transplant patients who have psoriasis can be a therapeutic challenge. Biologic and systemic drugs used to treat psoriasis can result in an increase in infections or malignancies. OBJECTIVE: We sought to develop a treatment algorithm for organ transplant recipients (OTR) diagnosed with psoriasis vulgaris. METHODS: A systematic literature search for psoriasis treatment in organ transplant patients was performed using MEDLINE and GOOGLE...
September 8, 2017: Journal of Dermatological Treatment
Thanh-Lan Bui, Catalina Silva-Hirschberg, Josefina Torres, April W Armstrong
PURPOSE: The primary aim of this study was to evaluate the readability, understandability, suitability, and actionability of online psoriasis patient educational materials. A secondary aim was to identify areas for improvement. MATERIALS AND METHODS: We conducted an evaluation study to assess online psoriasis patient educational materials from the American Academy of Dermatology and National Psoriasis Foundation available in July 2017. We used two validated assessment tools specific to online healthcare materials...
September 4, 2017: Journal of Dermatological Treatment
Jean-Marie Lachapelle, Ana Gimenez-Arnau, Martin Metz, Jill Peters, Ehrhardt Proksch
Contact dermatitis (CD) is caused by environmental agents, irritants and allergens, that penetrate the epidermis and lead to inflammation. An intact skin barrier prevents penetration and is important in maintaining healthy skin. Classical diagnosis of CD is made using the patch test, and traditional treatment strategies for CD promote skin barrier integrity and resolve the inflammatory component of the condition. This can be achieved by using emollient-based therapy, which is most important for skin barrier repair, and in addition to topical glucocorticosteroids, which are used in severe cases of CD and are most effective in reducing inflammation...
September 4, 2017: Journal of Dermatological Treatment
Dylan E Lee, Ashley K Clark, Khiem A Tran, Vivian Y Shi
PURPOSE: This is a review of emerging targeted, systemic therapies for atopic dermatitis (AD). The information presented aims to provide dermatologists with updated therapeutic options, stimulate academic interest, and spark future research. MATERIALS AND METHODS: Extensive search of, the National Eczema Association, and PubMed was performed for clinical trials examining the effect of emerging targeted, systemic therapies in patients with AD. Results were included if they demonstrated efficacy in reversing AD symptoms...
August 30, 2017: Journal of Dermatological Treatment
Kam Lun Hon, Jeng Sum Charmaine Kung, Kathy Yc Tsang, Jasmine W Yu, Nancy Wong, Ting Fan Leung
AIM: It is important to objectively measure the severity of atopic dermatitis (AD). This study aims to investigate correlations among various clinical severity scores and determine how a severity score based on symptoms alone performs. METHODS: A modified symptom score based on Patient-Oriented Eczema Measure (POEM, a short-term subjective-symptom score), Scoring Atopic Dermatitis (SCORAD, a short-term subjective-symptom and objective-sign score), Nottingham Eczema Severity Score (NESS, a long-term subjective-symptom score), Children Dermatology Life Quality Index (CDLQI, a short-term subjective-symptom score), skin hydration (SH) and transepidermal water loss (TEWL) were compared and Spearman's rho correlations evaluated...
August 29, 2017: Journal of Dermatological Treatment
Paul Jarrett, Carlos Arturo Camargo, Christin Coomarasamy, Robert Scragg
PURPOSE: To investigate the clinical effect of vitamin D3 supplementation on psoriasis from a community-dwelling population. MATERIALS AND METHODS: Participants with psoriasis in a large randomized controlled trial examining the effect of vitamin D3 supplementation (100,000 IU monthly) in adults aged 50-84 years, were invited to participate in a psoriasis sub-study over 12 months. The primary outcome was the Psoriasis Area and Severity Index (PASI) and secondary outcomes were Physicians Global Assessment (PGA), Dermatology Life Quality Index (DLQI) and Psoriasis Disability Index (PDI)...
August 29, 2017: Journal of Dermatological Treatment
Andrew T Rogers, Yevgeniy R Semenov, Shawn G Kwatra, Ginette A Okoye
PURPOSE: Racial health disparities are widespread in the United States, but little is known about racial disparities in the management of dermatological conditions. MATERIALS AND METHODS: Nationally representative data on the management of acne vulgaris were gathered from the National Ambulatory Medical Care Survey for the years 2005-2014. Visits to any specialist were included. Rao-Scott chi-square tests and multivariate adjusted logistic regressions were used to identify differences in patient demographics, visit characteristics, and acne medications across races...
August 23, 2017: Journal of Dermatological Treatment
Caitlin Gibbons, Sanminder Singh, Brittany Gibbons, Caitlin Clark, Josefina Torres, Michelle Y Cheng, Elizabeth A Wang, April W Armstrong
PURPOSE: In this systematic review, we aimed to synthesize data that identify factors contributing to patient satisfaction in dermatology care using qualitative methods. MATERIALS AND METHODS: We performed a comprehensive search of the literature using the PubMed database for articles published between January 1, 2000 and February 9, 2015. The initial search yielded 186 articles, of which 13 were included after applying inclusion and exclusion criteria. RESULTS: The systematic review of 13 articles included a total of 330 patients...
August 18, 2017: Journal of Dermatological Treatment
Audrey Rutherford, Donald A Glass, Elizabeth A Suarez, Adewole S Adamson
PURPOSE: To analyze factors associated with primary nonadherence to dermatologic medications and study whether prescription-level factors are associated with primary nonadherence. MATERIALS AND METHODS: A retrospective review of medical records of new dermatology patients from January 2011 to December 2013 at a single urban safety-net hospital outpatient dermatology clinic with a closed pharmacy system. RESULTS: A total of 4307 prescriptions were written for 2490 patients...
August 18, 2017: Journal of Dermatological Treatment
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