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Journal of Dermatological Treatment

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https://www.readbyqxmd.com/read/29683760/mycophenolate-mofetil-therapy-in-adult-patients-with-recalcitrant-atopic-dermatitis
#1
David Dias-Polak, Reuven Bergman, Emily Avitan-Hersh
Patients with severe atopic dermatitis (AD) may require potent immunosuppressive therapy to control their disease. Mycophenolate mofetil (MMF) has been suggested as a safe and effective drug in these cases. We have used oral MMF 2-3gr/day in adult patients with severe recalcitrant AD who failed other major systemic drugs, or where other drugs, including cyclosporine, methotrexate and azathioprine, were contraindicated. Of 9 consecutive adult patients, 4 (44%) responded completely, 2 (22%) had partial response and 3 (33%) did not respond at all...
April 23, 2018: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/29683393/usefulness-and-correlation-with-clinical-response-of-serum-ustekinumab-levels-measured-at-6-weeks-versus-12-weeks
#2
M Toro-Montecinos, F Ballescá, C Ferrandiz, A Teniente-Serra, E Martinez-Caceres, J M Carrascosa
BACKGROUND: Monitoring serum drug levels has been proposed as a useful tool for improving and personalising the management of psoriasis. However, in the case of ustekinumab the usefulness of such monitoring was not demonstrated when drug levels were measured at week 12. OBJECTIVES: To evaluate the correlation of serum ustekinumab levels measured at weeks 6 and 12 with clinical response. METHODS: In a prospective cohort study, we enrolled patients with psoriasis treated with ustekinumab 45 mg every 12 weeks for at least 24 weeks...
April 23, 2018: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/29683361/human-recombinant-epidermal-growth-factor-in-skin-lesions-77-cases-in-epitelizando-project
#3
Jordi Esquirol-Caussa, Elisabeth Herrero-Vila
OBJECTIVE: To analyze compounded recombinant human Epidermal Growth Factor (rhEGF) effectiveness on skin lesions through a case series. DESIGN: Multicentric series of skin lesions treated with topical recombinant human Epidermal Growth Factor. SITE: Patients from 56 different health professionals, three different countries, two recruitment years. PARTICIPANTS: 77 patients with skin lesions, mean age 63.15 years (min = 18, max = 95); 53...
April 23, 2018: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/29678120/psoriasis-management-in-actual-clinical-practice-a-6-year-retrospective-study-of-845-patients
#4
Pinar Incel Uysal, Buket Sahin, Basak Yalcin, Afra Alkan, Selcen Yuksel
BACKGROUND: Over the past years, with the availability of relatively well tolerated, very effective but expensive drugs, biologics, treatment of psoriasis has dramatically shifted from inpatient modalities to outpatient ones. Relatively little is known about true life practices regarding psoriasis treatment in our country. AIMS: To assess the impact of introduction of conventional drugs and biological drugs on medical resource use of psoriasis patients. STUDY DESIGN: A retrospective chart review was performed...
April 20, 2018: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/29676599/psoriasis-in-pregnancy-case-series-and-literature-review-of-data-concerning-exposure-during-pregnancy-to-ustekinumab
#5
M Galluzzo, S D'Adamio, L Bianchi, M Talamonti
Psoriasis tends to improve for approximately half of patients during pregnancy, but an equal number of patients report no change or worsening during this period, when lots of medications, like biologics, are not indicated. The aim of our study was to review data of patient that had been pregnant during ustekinumab treatment, analyzing data of our data set between September 2010 and February 2018. We found data of three patients that had been pregnant during ustekinumab treatment. All three patients successfully completed the pregnancy without complications...
April 20, 2018: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/29676592/pulsed-dye-laser-as-an-adjuvant-treatment-for-discoid-lupus-erythematosus-a-randomized-controlled-trial
#6
Pawinee Rerknimitr, Nucharin Tekacharin, Ratchathorn Panchaprateep, Jade Wititsuwannakul, Pattarin Tangtanatakul, Nattiya Hirankarn, Pravit Asawanonda
PURPOSE: To evaluate the efficacy and safety of PDL for DLE in a double blinded, randomized, controlled fashion. METHOD: Forty-eight DLE lesions from nine patients were recruited. The lesions on one side of the body were randomized into the treatment group and the other side served as a control. Treatments with the PDL (595nm) were delivered every 4 weeks for 4 consecutive months. The patients were evaluated at weeks 0, 4, 8, 12, 16 and 24. Erythema index (EI) and Texture index (TI) were obtained by Antera3D®...
April 20, 2018: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/29676591/a-retrospective-observational-study-on-biological-drug-treatment-in-a-daily-practice-serving-patients-with-psoriasis-in-japan
#7
Chika Ohata, Bungo Ohyama, Aya Nanri, Takako Shintani, Takekuni Nakama
BACKGROUND: In Japan, more than 5 years have passed since emergence of the first 3 biologics, infliximab, adalimumab, and ustekinumab, became available in daily practice; however, no data for drug survival was reported from Japan. OBJECTIVE: To study the long-term drug survival of infliximab, adalimumab, and ustekinumab used for Japanese psoriatic patients. METHODS: We retrieved data on all patients treated with biological agents and calculated the long-term drug survival for infliximab, adalimumab, and ustekinumab using our psoriasis registry (Kurume Psoriasis Registry: KURUPR) consisted of 343 patients by the end of March 2017...
April 20, 2018: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/29676194/dose-duration-and-cost-opportunities-to-improve-use-of-long-term-oral-antibiotics-for-people-with-rosacea
#8
Joanne S Rill, Hadar Lev-Tov, Guodong Liu, Joslyn S Kirby
BACKGROUND: Systemic antibiotics are often used to treat rosacea and tetracyclines are the most common antibiotic prescribed; however, there is ambiguity among clinical guideline suggestions. Importantly, there is an increasing call to all clinicians to curtail antibiotic use. OBJECTIVE: Investigate the utilization and cost of long-term oral antibiotic use for the treatment of rosacea, including ocular rosacea. METHODS: This was a retrospective cohort study of MarketScan® Commercial Claims and Encounters database, from January 1, 2005 through December 31, 2014...
April 20, 2018: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/29676189/association-between-clinical-factors-and-dose-modification-strategies-in-the-treatment-with-ustekinumab-for-moderate-to-severe-plaque-psoriasis
#9
Rosa M Romero-Jimenez, Vicente Escudero-Vilaplana, Ofelia Baniandres Rodriguez, Estela García Martín, Ana Mateos Mayo, Maria Sanjurjo Saez
PURPOSE: The aim of this study was to identify clinical factors associated with dose reduction and dose escalation in the treatment with ustekinumab in patients with moderate to severe plaque psoriasis. MATERIALS AND METHODS: An observational, longitudinal and retrospective study was conducted using patients with moderate to severe plaque psoriasis. We reviewed clinical histories and variables were recorded on a database (patients' characteristics, pharmacotherapeutics, effectiveness and safety)...
April 20, 2018: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/29676186/it-takes-one-to-know-one-exploring-patient-dialogue-on-rosacea-web-based-platforms-and-their-potential-for-significant-harm
#10
Laura H Riddoch
BACKGROUND: Rosacea is a non-curable skin condition, leading patients to turn self-management options from web based platforms. Self-management can be dangerous possibly under-reported. AIM: To discover the extent of online material and determine the potential for harm influenced by rosacea internet sources. MATERIALS AND METHODS: Material analysed included search engines, apps, YouTube, forums and Facebook groups. As Facebook and forums were most active, they became the core focus...
April 20, 2018: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/29671670/challenges-in-assessing-rare-risks-associated-with-topical-calcineurin-inhibitors-for-the-treatment-of-eczema
#11
Brent L Cao
No abstract text is available yet for this article.
April 19, 2018: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/29671667/clinical-utility-of-marketing-terms-used-for-over-the-counter-dermatologic-products
#12
Emily Boozalis, Shivani Patel
BACKGROUND: Cosmetic products are commonly marketed using dermatologic terms such as "hypoallergenic," "non-comedogenic," "fragrance-free," etc. The clinical relevance of these claims can be confusing to both patients and clinicians. METHODS: A systematic review was performed from via a PubMed search of published articles from January 1985 to October 2017 to further describe and elucidate the clinical utility of a predefined list of common dermatologic terms used by pharmaceutical companies to market over the counter products...
April 19, 2018: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/29671665/effects-of-etanercept-on-the-patient-perceived-results-pros-in-patients-with-moderate-to-severe-plaque-psoriasis-systematic-review-of-the-literature-and-meta-analysis
#13
Jose Manuel Carrascosa, Francisco Rebollo, Susana Gómez, Pablo de la Cueva
PURPOSE: To evaluate the efficacy of etanercept (ETN) compared with placebo for moderate-to-severe psoriasis regarding patients reported outcomes (PROs). METHODS: Systematic review of studies retrieved by a sensitive search strategy in Medline, Embase, Cochrane Library. SELECTION CRITERIA: (population) studies had to include patients with for moderate-to-severe psoriasis; (intervention and control) studies had to test ETN vs placebo; and (outcomes), studies had to report PROs including quality of life, pain, pruritus or sleep...
April 19, 2018: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/29671663/a-note-on-improvement-in-dermatology-life-quality-index-dlqi-among-patients-with-hidradenitis-suppurativa-treated-with-adalimumab
#14
Simon Francis Thomsen
Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease with profound negative impact on quality of life. Adalimumab (anti-TNF) is indicated for moderate-to-severe HS unresponsive to conventional therapy. Herein, studies of the change in Dermatology Life Quality Index (DLQI) among patients with HS treated with adalimumab are reviewed. The anticipated gain in DLQI is only modest in patients with HS treated with adalimumab, even in trials of high quality, and does not exceed the established minimal clinically important difference...
April 19, 2018: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/29671656/interferon-beta-injection-site-reactions-in-patients-with-multiple-sclerosis
#15
Martina Maurelli, Roberto Bergamaschi, Ambra Antonini, Maria Concetta Fargnoli, Elisa Puma, Giulia Mallucci, Rocco Totaro, Giampiero Girolomoni
Interferon-beta (IFNβ) are effective treatments for relapsing multiple sclerosis. IFNβ treatment includes subcutaneous (sc) IFNβ-1b, intramuscular and sc IFNβ-1a, and sc pegylated IFNβ-1a (PEG-IFNβ-1a). PEG-IFNβ-1a offers the advantage of a prolonged duration of action with a less frequent administration (every 2 weeks) and a higher patient adherence. However, the use of subcutaneous interferons could be characterized by potential skin toxicity. Injection site reactions (ISRs), featured by erythema, edema, pain and pruritus, are the most common adverse reactions...
April 19, 2018: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/29671368/the-efficacy-of-topical-human-amniotic-membrane-mesenchymal-stem-cell-conditioned-medium-hammsc-cm-and-a-mixture-of-topical-hammsc-cm-vitamin-c-and-hammsc-cm-vitamin-e-on-chronic-plantar-ulcers-in-leprosy-a-randomized-control-trial
#16
Crs Prakoeswa, F R Natallya, D Harnindya, A Thohiroh, R N Oktaviyanti, K D Pratiwi, M A Rubianti, B Yogatri, P I Primasari, N Herwanto, M D Alinda, B H Kusumaputra, L Astari, M Y Listiawan, I Agusni, F A Rantam
BACKGROUND: Healing of chronic plantar ulcers in leprosy (CPUL) typically takes a long time due to impaired neurological function, thereby reducing the levels of growth factors and cytokines. Cytokines can be found in metabolite products from amniotic membrane stem cells. Chronic ulcers are frequently characterized by high levels of reactive oxygen species. Vitamin E (α-tocopherol) is widely used in skin lesions, owing to its antioxidant and anti-inflammatory properties. Vitamin C also has antioxidant, anti-inflammatory, and collagen synthesis properties useful in wound healing...
April 19, 2018: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/29668335/electrocardiographic-changes-after-high-dose-corticosteroid-pulse-therapy-in-pemphigus-patients
#17
M Pishgahi, S Dadkhahfar, R M Robati, Z Kheradmand, M Shahidi-Dadras, O Zargari, D J Elpern
PURPOSE: The objective of the current study was to evaluate the effect of intravenous methylprednisolone pulse therapy on myocardial repolarization alterations, especially QT dispersion in anticipation of cardiovascular risks in patients with pemphigus vulgaris. METHODS: The current study is a prospective controlled study on the electrocardiographic changes after methylprednisolone pulse therapy in 50 patients with pemphigus vulgaris. RESULTS: A total of 50 patients (28 female and 22 male) were included in our study...
April 18, 2018: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/29667472/evaluation-of-the-effect-of-pulsed-dye-laser-on-chronic-psoriatic-plaque
#18
Nagwa Mohammad Elwan, Shereen Farouk Gheida, Soha Abdalla Hawwam, Abeer Hussien Ahmed
Psoriasis is one of the most prevalent immune mediated skin diseases. Selective vascular destruction by pulsed dye laser is considered one of effective laser treatments. OBJECTIVE: Evaluation of the therapeutic effect of pulsed dye laser in treatment of chronic psoriatic plaque lesions and changes in human beta defensin-2 expression in the psoriatic patients before and after treatment, with correlation to the clinical improvement. METHODS: Twenty patients with psoriatic plaque on right side treated by laser and another plaque on left side similar in size and severity score as control receiving no treatment...
April 18, 2018: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/29658800/nail-involvement-in-patients-with-moderate-to-severe-alopecia-areata-treated-with-oral-tofacitinib
#19
Ji Su Lee, Chang-Hun Huh, Ohsang Kwon, Hyun-Sun Yoon, Soyun Cho, Hyun-Sun Park
BACKGROUND: A few anecdotal case reports demonstrated that tofacitinib improved nail changes associated with AA. OBJECTIVE: To investigate nail changes in patients with AA treated with tofacitinib and evaluate the relationship between nail and hair responses to tofacitinib. METHODS: This is a retrospective study of 33 adult patients with moderate-to-severe AA treated with oral tofacitinib monotherapy for at least 4 months. RESULTS: Fifteen patients had nail involvement and demonstrated more severe hair loss than those without nail involvement (p = 0...
April 16, 2018: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/29658383/comparison-of-the-cost-effectiveness-of-biologic-drugs-used-for-moderate-to-severe-psoriasis-treatment-in-the-united-states
#20
Jashin J Wu, Steven R Feldman, Shipra Rastogi, Brandy Menges, Melissa Lingohr-Smith, Jay Lin
PURPOSE: To compare the cost-effectiveness of the newly approved biologic drug, brodalumab, with other commonly used biologics for the treatment of moderate-to-severe psoriasis in the U.S. METHODS: An economic model was constructed in Excel to compare average costs to achieve Psoriasis Area and Severity Index (PASI) 75, 90, and 100 among moderate-to-severe psoriasis patients treated with biologics. Total annual costs to health plans associated with treatment with 5 different biologics were estimated and cost-effectiveness compared using the estimated average cost per PASI 75, PASI 90, and PASI 100...
April 16, 2018: Journal of Dermatological Treatment
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