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Journal of Dermatological Treatment

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https://www.readbyqxmd.com/read/27884065/the-efficacy-of-two-formulations-of-botulinum-toxin-type-a-for-masseter-reduction-a-split-face-comparison-study
#1
Rungsima Wanitphakdeedecha, Chanida Ungaksornpairote, Arisa Kaewkes, Angkana Sathaworawong, Nittaya Lektrakul, Woraphong Manuskiatti
BACKGROUND: Botulinum toxin type A (BTA) is now extensively used to address cosmetic concerns. OnabotulinumtoxinA (ONA, Botox; Allergan Inc., Irvine, CA) received FDA approval for upper face rejuvenation, including glabella frown lines and crow's-feet lines. The other off-label uses for lower face conditions have been utilized for contouring purposes, especially masseter hypertrophy. Recently, a new Daewoong BTA, (NABOTA(®), NBT, Daewoong Pharmaceutical, Seoul, Korea), was recently introduced...
December 6, 2016: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/27764972/the-dermatologic-intimacy-scale-quantitatively-measuring-the-impact-of-skin-disease-on-intimacy
#2
Mona Malakouti, Gabrielle E Brown, Argentina Leon, Eva Wang, April N Naegeli, Emily Edson-Heredia, Ethan Levin, John Y M Koo
INTRODUCTION: Patient-reported outcome measures are increasingly utilized in dermatology to assess the impact of skin disease on quality of life. Despite recognition of the influence of skin disease on intimate relationships, an instrument to assess intimacy has not been developed. The objective of this study was to create the dermatologic intimacy scale (DIS) and administer the prototype to a patient population. METHODS: A group of healthcare providers at the University of California San Francisco created the DIS prototype...
December 6, 2016: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/27881030/the-effect-of-tumour-necrosis-factor-inhibitor-therapy-on-the-incidence-of-myocardial-infarction-in-patients-with-psoriasis-a-retrospective-study
#3
Dalia Shaaban, Nawaf Al-Mutairi
BACKGROUND: Psoriasis has been shown to be associated with increased incidence of myocardial infarction (MI). The data on the effect of tumour necrosis factor (TNF) inhibitors on MI in psoriasis are scarce. OBJECTIVE: To evaluate the effect of TNF inhibitors on the risk of MI in psoriasis patients compared with methotrexate (MTX) and topical agents. METHODS: Data was obtained from the Electronic Health Records database of Farwaniya Hospital from psoriasis patients seen from January 2008 to December 2014...
November 24, 2016: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/27813433/factors-affecting-the-rise-of-treatment-of-resistant-bacteria-in-skin-and-soft-tissue-infections-in-the-united-states-1993-2012
#4
Margaret E Wetzel, Alan B Fleischer
BACKGROUND: Methicillin-resistant Staphylococcus aureus (MRSA) skin and soft tissue infections (SSTIs) prevalence has been steadily increasing for the past 40 years. The increase in such infections has contributed to a change in the treatment patterns of the patient. This study aimed to detail the factors determining prescription practices associated with MRSA-related skin and soft tissue infections. METHODS: The National Ambulatory Medical Care Survey (NAMCS) was searched for data from 1993 to 2012 regarding the factors associated with resistant vs...
November 22, 2016: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/27796136/rituximab-treatment-of-pemphigus-in-women-of-childbearing-age-experience-with-two-patients
#5
Eden P Lake, Yu-Hui Huang, Iris K Aronson
Pemphigus vulgaris is an autoimmune blistering disorder treated with systemic steroids and immunosuppressive agents. Treatment of this disorder in young women of childbearing age must take into consideration the patient's desire for pregnancy and effects of the treatment on both mother and child. We report two young women with pemphigus, initially treated with standard immunosuppressive medications, who expressed their wishes for pregnancy. The immunosuppressive agents were tapered and both patients were treated with Rituximab and IVIG, permitting discontinuation of other medications, conception and pregnancy without any oral steroids or immunosuppressive agents...
November 20, 2016: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/27794626/psoriasis-increases-risk-of-new-onset-atrial-fibrillation-a-systematic-review-and-meta-analysis-of-prospective-observational-studies
#6
Sikarin Upala, Afeefa Shahnawaz, Anawin Sanguankeo
BACKGROUND: Psoriasis is a common chronic immune-mediated dermatological disease that increases the risk of cardiovascular disease. We conducted a systematic review and meta-analysis to evaluate the association between psoriasis and atrial fibrillation from prospective observational studies. METHODS: A comprehensive search of the databases of the MEDLINE and EMBASE was performed from inception through November 2015. The inclusion criterion was the prospective observational study that assessed the risk of new-onset atrial fibrillation in adults with psoriasis...
November 18, 2016: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/27791446/treatment-patterns-in-moderate-to-severe-plaque-psoriasis-results-from-a-belgian-cross-sectional-study-discover
#7
Julien Lambert, Pierre-Dominique Ghislain, Jo Lambert, Bénédicte Cauwe, Maria Van den Enden
PURPOSE: The present study aimed to evaluate current treatment patterns and achievement of treatment goals in Belgian patients with moderate-to-severe plaque psoriasis. MATERIALS AND METHODS: This cross-sectional observational study (DISCOVER) was conducted in 2011 - 2012 in Belgian dermatology centers. Patient data were collected during a single visit and included information on psoriasis management and severity (PASI and DLQI). Treatment success was defined according to the current European consensus treatment goal algorithm...
November 15, 2016: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/27791434/a-comparative-study-of-pulsed-dye-laser-versus-long-pulsed-nd-yag-laser-treatment-in-recalcitrant-viral-warts
#8
Yo Sup Shin, Eun Byul Cho, Eun Joo Park, Kwang Ho Kim, Kwang Joong Kim
BACKGROUND: Viral warts are common infectious skin disease induced by human papillomavirus (HPV). But the treatment of recalcitrant warts is still challenging. OBJECTIVE: In this study, we compared the effectiveness of pulsed dye laser (PDL) and long pulsed Nd:YAG (LPNY) laser in the treatment of recalcitrant viral warts. METHODS: We retrospectively analyzed the medical records of patients with recalcitrant warts treated with laser therapy between January 2013 and February 2016...
November 15, 2016: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/27786580/postinflammatory-hyperpigmentation-associated-with-treatment-of-solar-lentigines-using-a-q-switched-532-nm-nd-yag-laser-a-multicenter-survey
#9
Hyun Ji Kang, Jung Im Na, Jong Hee Lee, Mi Ryung Roh, Joo Yeon Ko, Sung Eun Chang
PURPOSE: To characterize the risk factors of Korean patients for postinflammatory hyperpigmentation (PIH) during treatment of solar lentigines using a Q-switched 532-nm Nd: YAG (QS 532 NY) laser. MATERIALS AND METHODS: The present retrospective multicenter study was conducted at the dermatology clinics of five tertiary hospitals in Korea. Between October 2007 and January 2013, 516 patients were enrolled and reviewed for clinical features and factors associated with PIH...
November 15, 2016: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/27783534/healthcare-resource-utilization-healthcare-costs-and-dose-escalation-in-psoriasis-patients-initiated-on-ustekinumab-versus-adalimumab-a-retrospective-claim-study
#10
Jashin J Wu, Annie Guérin, Geneviève Gauthier, Murali Sundaram
BACKGROUND: Adalimumab and ustekinumab are effective psoriasis treatments. This study compares healthcare resource utilization (HRU), costs and dose escalation and describes starting dose trends in ustekinumab versus adalimumab psoriasis patients. METHODS: Adult psoriasis patients initiating adalimumab/ustekinumab on/after 25 September 2009 were selected from a US claims database and classified into biologic-naïve and biologic-experienced samples. RESULTS: A total of 602 ustekinumab and 3470 adalimumab biologic-naïve and 1193 ustekinumab and 1467 adalimumab biologic-experienced patients were included...
November 15, 2016: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/27796187/real-world-approach-to-actinic-keratosis-management-practical-treatment-algorithm-for-office-based-dermatology
#11
Thomas Dirschka, Girish Gupta, Giuseppe Micali, Eggert Stockfleth, Nicole Basset-Séguin, Véronique Del Marmol, Reinhard Dummer, Gregor B E Jemec, Josep Malvehy, Ketty Peris, Susana Puig, Alexander J Stratigos, Iris Zalaudek, Giovanni Pellacani
Actinic keratosis (AK) is a chronic skin disease in which multiple clinical and subclinical lesions co-exist across large areas of sun-exposed skin, resulting in field cancerisation. Lesions require treatment because of their potential to transform into invasive squamous cell carcinoma. This article aims to provide office-based dermatologists and general practitioners with simple guidance on AK treatment in daily clinical practice to supplement existing evidence-based guidelines. Novel aspects of the proposed treatment algorithm include differentiating patients according to whether they have isolated scattered lesions, lesions clustered in small areas or large affected fields without reference to specific absolute numbers of lesions...
November 13, 2016: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/27786594/worldwide-utilization-of-topical-remedies-in-treatment-of-psoriasis-a-systematic-review
#12
Mathias Tiedemann Svendsen, Janithika Jeyabalan, Klaus Ejner Andersen, Flemming Andersen, Helle Johannessen
OBJECTIVE: To review published literature describing the global use of topical antipsoriatics. MATERIALS AND METHODS: Search for English-language articles in Embase, Pubmed, PsycINFO and Cochrane Library. RESULTS: Fifty-four selected publications were found, describing psoriasis patients' use of topical antipsoriatics, using six different methods to collect data. The eight most frequently used topical treatments from the regions North/South America, North/Central/South Europe, Asia, Middle East and Australia were: corticosteroids used by 16-79%, complementary and alternative medicines used by 10-62%, phototherapies used by 0...
November 13, 2016: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/27759463/sustained-response-with-ixekizumab-treatment-of-moderate-to-severe-psoriasis-with-scalp-involvement-results-from-three-phase-3-trials-uncover-1-uncover-2-uncover-3
#13
Kristian Reich, Craig Leonardi, Mark Lebwohl, Francisco Kerdel, Yukari Okubo, Ricardo Romiti, Orin Goldblum, Ellen B Dennehy, Lisa Kerr, Howard Sofen
BACKGROUND: Scalp is a frequently affected and difficult-to-treat area in psoriasis patients. OBJECTIVE: We assessed the efficacy of ixekizumab in the treatment of patients with scalp psoriasis over 60 weeks using the Psoriasis Scalp Severity Index (PSSI). METHODS: In three Phase 3, multicenter, double-blind, placebo-controlled trials, patients with moderate-to-severe psoriasis in UNCOVER-1 (N = 1296), UNCOVER-2 (N = 1224) and UNCOVER-3 (N = 1346) were randomized to subcutaneous 80 mg ixekizumab every two weeks (Q2W) or every four weeks (Q4W) after a 160 mg starting dose, or placebo through Week 12...
November 13, 2016: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/27832717/secukinumab-provides-better-relief-from-the-impact-of-psoriasis-on-daily-activities-and-personal-relationships-than-etanercept-results-of-two-phase-3-placebo-controlled-randomized-clinical-trials-in-moderate-to-severe-psoriasis
#14
Neil J Korman, Howard Sofen, Scott Fretzin, Phoebe Rich, Yang Zhao, Vivian Herrera, Judit Nyirady, Nicole Williams, Margaret Mordin, Stephen Tyring
BACKGROUND: Psoriasis can greatly impact patients' lives, influencing what clothing they wear and impairing their sexual functioning. OBJECTIVE: To provide a detailed comparison of the impact of secukinumab versus etanercept on enabling patients with psoriasis to have more normal lives with respect to daily activities (e.g., choosing clothing) and personal relationships (e.g., sexual functioning). METHODS: Baseline to Week 52 ERASURE and FIXTURE data for secukinumab 300 mg and etanercept were analyzed...
November 11, 2016: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/27826988/treatment-of-corticosteroid-refractory-alopecia-totalis-with-oral-tacrolimus
#15
E Verga, C Hayes, A Liakopoulou, R Verdolini
No abstract text is available yet for this article.
November 9, 2016: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/27759482/dermatologic-uses-of-omalizumab
#16
Justin C Chia, P Régine Mydlarski
PURPOSE: Omalizumab is a recombinant humanized monoclonal antibody that inhibits the binding of immunoglobulin E (IgE) to the high-affinity IgE receptor (FceRI) on the surface of mast cells and basophils. Omalizumab has been approved for use in asthma, and new reports show promise in a variety of dermatologic diseases. Herein, we review the literature on omalizumab in dermatology and discuss the safety, efficacy and mechanisms of action for this emerging therapy. MATERIALS AND METHODS: PubMED, MEDLINE and Embase databases were searched for the period 1 January 1990 to 1 September 2016...
November 7, 2016: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/27807999/topical-corticosteroid-concerns-from-the-clinicians-perspective
#17
Simon M Mueller, Dominique Tomaschett, Deborah R Vogt, Peter Itin, Antonio Cozzio, Christian Surber
PURPOSE: Topical corticosteroids concerns (TCC) are common in dermatology patients, possibly leading to non-adherence to topical corticosteroids (TCS) and poor disease control. Clinicians play a key role in that context, as they can reduce or reinforce these concerns. It is unknown, if clinicians have accurate knowledge of TCC to appropriately address this issue and whether they have concerns themselves to use TCS. This questionnaire-based study aimed to assess these two aspects. MATERIALS AND METHODS: Accuracy of knowledge was defined by how close the clinician's estimates were to reference values of our previous study, in which we had examined TCC in dermatology outpatients...
November 3, 2016: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/27798973/different-doses-of-gabapentin-formulations-for-postherpetic-neuralgia-a-systematical-review-and-meta-analysis-of-randomized-controlled-trials
#18
Juan Wang, Yuyou Zhu
WHAT IS KNOWN AND OBJECTIVE: Gabapentin, extended-release gabapentin (gabapentin ER), and gabapentin enacarbil (GEn), play an important role in relieving pain associated with postherpetic neuralgia (PHN). Although previous systematic reviews have assessed the efficacy and safety of gabapentin formulations for PHN, they have failed to take formulation differences and dose differences into account. Aiming at assessing the efficacy and safety of different doses of gabapentin formulations for PHN, this study performed a systematical review and meta-analysis of randomized controlled trials (RCTs)...
November 1, 2016: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/27796155/investigation-of-the-effects-of-systemic-isotretinoin-treatment-on-retinal-nerve-fiber-layer-and-macula
#19
Uğur Yılmaz, Erkut Kucuk, Cagdas Koc, Ayse Ozkose
PURPOSE: To investigate the effects of systemic isotretinoin therapy on retina by measuring retinal nevre fiber layer(RNFL) and macular thicknesses. METHOD: This prospective, cross-sectional study was conducted in patients prescribed systemic isotretinoin therapy. 72 eyes of 36 patients were included in the study. The patients were followed during three months. Detailed opthalmologic examination including anterior and posterior segment examination, best corrected visual acuity and intraocular pressure measurement, RNFL and macular thicknesses measurement by Spectral Domain Cirrus Optical Coherence Tomography Model 400 (Carl Zeiss Meditech, Jena, Germany) were performed at baseline, first, second and third months after the beginning of systemic isotretinoin therapy in ophthalmology clinic...
October 31, 2016: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/27796132/carbon-dioxide-laser-versus-erbium-yag-laser-in-treatment-of-epidermal-verrucous-nevus-a-comparative-randomized-clinical-study
#20
Mai Abdel Raouf Osman, Ahmed Nazmi Kassab
Background A verrucous epidermal nevus (VEN) is a skin disorder that has been treated using different treatment modalities with varying results. Ablative lasers such as Carbon dioxide laser (CO2) and erbium:yttrium-aluminum-garnet (Er:YAG) laser have been considered as the gold standard for treatment of epidermal naevi. Objective To evaluate and compare the efficacy, postoperative wound healing and side effects of pulsed CO2 laser and Er:YAG laser for the treatment of verrucous epidermal nevi. Materials and methods Twenty patients with localized VEN were randomly divided into two groups...
October 31, 2016: Journal of Dermatological Treatment
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