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Journal of Dermatological Treatment

Jean-François Stalder, Joachim W Fluhr, Tim Foster, Martin Glatz, Ehrhardt Proksch
In recent years, the importance of the microbiome in maintaining healthy skin has become apparent. Both the classic microbiology cultivation techniques used since the early 1970s and the next-generation sequencing procedures refined in the past decade reveal the importance of skin microbiome in healthy and diseased skin. To strengthen and eventually restore a healthy microbiome in patients with dermatological conditions like atopic dermatitis (AD), it is important to consider the factors that influence the composition of the microbiome, such as skin pH and skin barrier integrity...
October 16, 2018: Journal of Dermatological Treatment
Ramiz N Hamid, Christine S Ahn, William W Huang
Neratinib is a tyrosine kinase inhibitor that was FDA-approved for extended adjuvant treatment in adults with HER-2 positive breast cancer in 2017. Due to the novelty of the drug, there are no current reports in the literature of adverse cutaneous effects associated with neratinib therapy. We present a case of a woman on neratinib for HER-2 positive infiltrating ductal carcinoma of the right breast who presented to the dermatology clinic with changes to the fingernails, acne, and a rash on the face. Physical examination revealed erythema, induration, and some serum crust along the lateral nail folds of the right 4th and left 3rd digits as well as monomorphic acneiform papules and pustules on the face...
October 15, 2018: Journal of Dermatological Treatment
A Montes-Torres, G Aparicio, R Rivera, E Vilarrasa, M Marcellán, J Notario, C Soria, I Belinchón, P de la Cueva, M Ferrán, J M Carrascosa, F J Gómez, L Salgado, M Velasco, M A Descalzo, I García-Doval, E Daudén
BACKGROUND: The management of HIV-positive patients with psoriasis is controversial and limited to individual cases or short series of patients. OBJECTIVES: To evaluate the safety and effectiveness of conventional and biologic immunosuppressive drugs in the treatment of patients with psoriasis and concomitant HIV infection. METHODS: A retrospective multicenter study was conducted. The study included data from 2008 to 2016. Inclusion criteria were: HIV adult patients with moderate-to-severe psoriasis, HIV viral load determinations at baseline and at least after 6 months of treatment, and systemic immunosuppressive treatment for at least 6 months...
October 11, 2018: Journal of Dermatological Treatment
Jashin J Wu, Karen A Veverka, Minyi Lu, April W Armstrong
BACKGROUND: Clinical trials have established calcipotriene 0.005%/betamethasone dipropionate 0.064% (Cal/BD) foam as a well-tolerated and efficacious topical therapy for psoriasis. METHODS: A chart review of 24 US healthcare providers gathered real-world information (clinical characteristics and outcomes, safety, and resource utilization) for patients (≥18 years old) prescribed Cal/BD foam between January 1 and October 31, 2016, along with healthcare provider characteristics and perceptions of Cal/BD foam...
October 11, 2018: Journal of Dermatological Treatment
Latifa Khlifi, Hajer Graiet, Sondes Sahli, Manel Ben-Hadj-Mohamed, Souhir Khelil, Nadia Bouzidi, Abed Elhedi Miled
BACKGROUND: Pressure ulcers (PU) are serious medical problems that involve several factors. Recent studies suggest that oxidative stress along with chronic inflammation may cause and develop PU. However, the metabolic disturbances underlying PU are not totally known. The purpose of this study is to evaluate biochemical oxidative stress markers in Tunisian patients suffering of PU. METHODS: 100 adult patients with PU and 213 healthy adult controls were selected for the study...
October 9, 2018: Journal of Dermatological Treatment
Shuk Ching Chong, Kam Lun Hon, Liz Yuen, Cheung Lun Choi, W G G Ng, Tor Chiu
Epidermolysis Bullosa (EB) is a heterogeneous group of congenital blistering diseases that usually presents in the neonatal period. EB is classified into three major categories, each with many subtypes based on the precise location at which separation or blistering occurs, namely epidermolysis bullosa simplex (EBS), junctional epidermolysis bullosa (JEB) and dystrophic epidermolysis bullosa (DEB). We describe genetics of neonatal EB in Hong Kong. Two neonates of consanguineous Pakistani parents had the EB-Pyloric Atresia (EB-PA) variant...
October 3, 2018: Journal of Dermatological Treatment
Zachary Curry, Matthew C Johnson, Emily L Unrue, Steven R Feldman
BACKGROUND: Caregivers are often apprehensive about treating their child's atopic dermatitis with a topical corticosteroid. Typical concerns include anxiety regarding side effects and the perceived burden of treatment. The perception of burden may be modifiable through anchoring. OBJECTIVE: To evaluate caregivers' willingness to treat their child's atopic dermatitis with a topical corticosteroid once-daily if initially anchored to the idea of a four-times-daily treatment regimen...
October 2, 2018: Journal of Dermatological Treatment
Maria Esposito, Francesca Prignano, Franco Rongioletti, Katharina Hansel, Leonardo Bianchi, Leonardo Pescitelli, Linda Lazzeri, Federica Ricceri, Cristina Mugheddu, Mauro Bavetta, Arianna Zangrilli, Luca Bianchi, Vittorio Bini, Luca Stingeni
INTRODUCTION: During treatment with biologic agents for psoriasis in a number of patients a failure may occur and discontinuation with transitioning to an other drug or an optimization strategy, consisting in a dose-adjustment or a co-medication with a traditional systemic agent, reprent two possible alternatives. OBJECTIVE: The SAFARI study objective was a retrospective observation of adalimumab efficacy and safety profile after switching from other anti-TNFα agents related to clinician behaviour after the failure of the first-line agent...
October 1, 2018: Journal of Dermatological Treatment
G Pistone, R Gurreri, G Tilotta, E Castelli, M R Bongiorno
Nail involvement is frequent in patients with psoriasis, especially those with psoriatic arthritis, and can significantly impair quality of life. It is typically difficult to treat compared with skin lesions, although several conventional treatment options are available. The aim of this paper is to describe our experience in the treatment of nail psoriasis with secukinumab in a case series. Fifteen patients (11 males and 4 females), with moderate-severe plaque psoriasis and nail psoriasis, eligible for systemic therapy, received secukinumab...
October 1, 2018: Journal of Dermatological Treatment
M Papini, Y Natalini
Patients with psoriasis may be at higher risk of Candida spp. infection. Interleukin (IL)-17 acts in the prevention of those infections; it is also involved in the pathogenesis of psoriasis. Therefore, anti-IL17 antibodies - which have an established role in the treatment of psoriasis - may be associated with an increased incidence of Candida spp. infection, as it has been suggested in pivotal trials. We report the occurrence of those infections in psoriatic patients receiving secukinumab 300 mg. Sixteen patients, treated with secukinumab 300 mg, for one year, and documented by mycological examinations, did not present any increase in the occurrence of Candida spp...
October 1, 2018: Journal of Dermatological Treatment
Chutima Rungananchai, Narumol Silpa-Archa, Chanisada Wongpraparut, Bordeesuda Suiwongsa, Viboon Sangveraphunsiri, Woraphong Manuskiatti
BACKGROUND: The American Academy of Dermatology recommends reapplication of sunscreen every two hours for adequate sun protection when outdoor. However, the frequency of reapplication needed to achieve adequate protection in indoor workers remains unknown. OBJECTIVE: To investigate the persistence of sunscreen applied once in the morning on the face of indoor workers throughout a normal 8-hour workday. METHODS: This open-label trial included 20 healthy volunteers who work indoors...
October 1, 2018: Journal of Dermatological Treatment
G Pistone, G Tilotta, R Gurreri, S Curiale, M R Bongiorno
Psoriasis is a chronic inflammatory skin disease affecting 2-3% of the population in the world. The scalp is the most common, and frequently the first site of disease involvement. Occasionally it may be the only localization of psoriasis. Treatment of scalp psoriasis is often unsatisfactory, due to limited available topical therapy and reduced efficacy of some systemic drugs. Biologic therapies are recommended for severe psoriasis, resistant to topical treatment, but evidence from randomized, controlled studies is lacking regarding effectiveness on scalp-localized lesions...
October 1, 2018: Journal of Dermatological Treatment
Maria-Angeliki Gkini, Joao Nogueira, Tanyo Tanev, Padma Mohandas, Ruth Taylor, Anthony Bewley
INTRODUCTION: The majority of patients with delusional infestation (DI) seek help from dermatologists as they consider their condition to be of cutaneous origin and deny referral to psychiatrists, with the prevalence of the condition arising. Objectives of our study assess whether there is a fixed delusional ideation in patients with DI, 2. to assess the efficacy of managing such patients with combined dermatological and psychiatric treatment and test any correlation between BABS scores and other variables...
October 1, 2018: Journal of Dermatological Treatment
Daniel Butler, John Koo
No abstract text is available yet for this article.
September 30, 2018: Journal of Dermatological Treatment
Logan C DeBord, Viraat Patel, Tara L Braun, Harry Dao
Social media encompasses multiple sites for online communication that reach a large proportion of the global population. While the increase in number of publications investigating dermatology content on social media has paralleled the growth of social media in the past decade, there has not yet been an extensive review of past literature on this topic. Our objective is to summarize and analyze publications on the role of social media within the field of dermatology. Social media is frequently used by patients to solicit advice related to cutaneous concerns and even when seeking out a dermatologist, but it is underutilized among both clinicians marketing their practices and academicians collaborating with colleagues in the field...
September 28, 2018: Journal of Dermatological Treatment
Eugenio Provenzano, Pietro Morrone
This article reports the clinical history of a patient who had been affected by chronic spontaneous urticaria for 13 years, resistant to currently recommended therapy, and who was also diagnosed eosinophilic esophagitis. The anti-IgE monoclonal antibody omalizumab was rapidly effective and induced the clinical remission of both diseases.
September 28, 2018: Journal of Dermatological Treatment
Christina Dai, Shawn Shih, Amor Khachemoune
BACKGROUND: Skin substitutes are designed to accelerate wound healing by providing replacement of extracellular matrix and can be used to promote healing of both acute and chronic wounds. AIM: To describe advantages, disadvantages, and indications for different skin substitutes with the intention of providing a systematic framework that clinicians can easily utilize in clinical practice. MATERIALS AND METHOD: We conducted a PubMed, Cochrane Library, and company website search for publications using various search terms associated with skin substitutes...
September 28, 2018: Journal of Dermatological Treatment
Yasumi Kitahara, Seiichiro Hojo, Maiko Nomoto, Daisuke Onozuka, Masutaka Furue, Akihito Hagihara
BACKGROUND: A novel topical phosphodiesterase-4 inhibitor E6005 shows potential as effective treatment options for atopic dermatitis (AD); however, systemic exposure may cause potentially undesirable adverse reactions. In this study, we evaluated the relationship between the systemic exposure of E6005 and clinical parameters including skin condition and the incidence of AEs in patients with AD. METHODS: The association analysis used the clinical data obtained in a previously conducted clinical study with topical E6005 in adult patients with AD...
September 28, 2018: Journal of Dermatological Treatment
Cita Rosita Sigit Prakoeswa, Febrina D Pratiwi, Nanny Herwanto, Irmadita Citrashanty, Diah Mira Indramaya, Dwi Murtiastutik, Hari Sukanto, Fedik A Rantam
BACKGROUND: Photoaging is a complex biologic process that affects various layers of the skin with the major damage seen in the connective tissue of the dermis. Although rarely fatal, photoaging can significantly contribute to a loss of quality of life; therefore, it deserves attention. Researchers are continually searching for new compounds to develop rejuvenation therapies. Nowadays, the stem cell population has been discovered, and it shows capability to rejuvenate the skin. MATERIAL AND METHODS: This was an analytic experimental research conducted on a total of 48 women who were randomised into two groups; 24 women received amniotic membrane stem cell-conditioned medium (AMSC-CM) and the other 24 women received normal saline (NS)...
September 28, 2018: Journal of Dermatological Treatment
M Galluzzo, S D'Adamio, E Campione, S Mazzilli, L Bianchi, M Talamonti
Erythrodermic psoriasis is a severe variant of psoriasis characterized by prominent erythema, affecting the entire body surface. Management of erythrodermic psoriasis is difficult, not standardized, and often ineffective. As clinical studies are lacking, reporting of clinical experience with secukinumab may help to gather insight in this field. Here, we describe the case of a 55-year-old man, with a 10-year history of moderate-to-severe plaque psoriasis. He presents a flare of erythroderma involving approximately 90% of his body surface area and a Psoriasis Area and Severity Index score of 42, with an important impact on his quality of life (DLQI score was 20...
September 26, 2018: Journal of Dermatological Treatment
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