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Journal of Dermatological Treatment

Ricardo Romiti, Lincoln Helder Zambaldi Fabrício, Cacilda da Silva Souza, Leticia Oba Galvão, Caio Cesar Silva de Castro, Aripuanã Cobério Terena, Francisca Regina Oliveira Carneiro, Luiza Keiko Matsuka Oyafuso, Sueli Carneiro, Bernardo Gontijo, Clarice Marie Kobata, Maria de Fátima Paim de Oliveira, Tania Cestari, João Roberto Antônio, Gladys Aires Martins, Silvio Alencar Marques, Sulamita Costa Wirth Chaibub, Ana Carolina Belini Bazán Arruda, Paulo Antonio Oldani Félix, Renata Ferreira Magalhães, Luna Azulay Abulafia, Karine A Ferreira, Aline Medeiros da Silva, Bruno Leonardo Silva, Juliano Souza
PURPOSE: Data on chronic plaque psoriasis severity and its potential clinical and lifestyle implications in the Brazilian population are limited. The primary aim of this study was to assess the clinical severity of plaque psoriasis in Brazil. Further objectives included evaluating potential associations between disease severity and demographic, lifestyle, and clinical characteristics, health-related quality of life (HRQOL), and work productivity. MATERIALS AND METHODS: This observational (non-interventional) cross-sectional study was conducted in 26 dermatologic clinics across 11 Brazilian states...
June 17, 2018: Journal of Dermatological Treatment
Lajos Kemény, Lovisa Berggren, Martin Dossenbach, Yves Dutronc, Carle Paul
PURPOSE: To evaluate short- and long-term efficacy and safety of ixekizumab in patients according to psoriasis severity. MATERIALS AND METHODS: Data were integrated from clinical trials (UNCOVER-2, UNCOVER-3). Patients received placebo, 80-mg ixekizumab every 2 weeks (IXEQ2W), every 4 weeks (IXEQ4W), or 50 mg etanercept (ETN) biweekly for 12 weeks, then open-label IXEQ4W (UNCOVER-3). Psoriasis severity was categorized by baseline Psoriasis Area and Severity Index (PASI <20 and ≥20)...
June 12, 2018: Journal of Dermatological Treatment
Iris Amitay-Laish, Ofer Reiter, Hadas Prag-Naveh, Ruben Kershenovich, Emmilia Hodak
BACKGROUND: Retinoids exert their biologic effects by binding to intracellular retinoic-acid receptors (RARs) and/or retinoid X receptors (RXRs). Early-stage mycosis fungoides (MF) has been effectively treated with bexarotene, an RXR-agonist, with overall response (OR) rates 54%-67% and complete response (CR) rates 7%-27%. Data on RAR-agonist monotherapy are limited. OBJECTIVE: To analyze the effectiveness of RAR-agonist monotherapy for early-stage MF. METHODS: Data on patients with early-stage MF treated with acitretin/isotretinoin monotherapy at a tertiary cutaneous lymphoma clinic in 2010-2017 were collected retrospectively from the medical files...
June 11, 2018: Journal of Dermatological Treatment
Issam Hamadah, Muzamil A Chisti, Mansoor Haider, Yousef Binamer, Saad Alajlan, Yousif Aleyouni, Abdullah Alfadley
BACKGROUND: Pemphigus is a chronic potentially life threatening autoimmune blistering disease affecting the skin and/or mucous membranes. Rituximab is being increasingly used and found efficacious in the treatment of pemphigus. OBJECTIVE: To present the Middle-Eastern experience with the use of rituximab in pemphigus. METHODS: A retrospective analysis of patient files was conducted which revealed twenty-three patients of pemphigus who were treated with rituximab(either alone or with IVIG) in the dermatology department of a tertiary care hospital from July-2004 to Dec-2014...
June 11, 2018: Journal of Dermatological Treatment
Ewa Chlebus, Monika Serafin, Marcin Chlebus
BACKGROUND: Adult acne is a chronic disease with uncontrolled exacerbations, associated with a psychological burden of the patient and medical expenses. AIMS: The aim of the study was to check the efficacy of maintenance therapy of adult acne. It is essential part of treatment as adult acne usually has a long-lasting and recurring course. METHODS: In the study the efficacy of maintenance therapy in patients with adult acne is evaluated. In this study, 100 patients (aged 25-39 years of age) with mild and moderate adult acne were enrolled...
June 6, 2018: Journal of Dermatological Treatment
Lianbo Zhang, Haiyan Qin, Zhuoxia Wu, Wanying Chen, Guang Zhang
BACKGROUND: We aimed to explore potential molecular basis of keloid formation and response mechanism of keloid to hydrocortisone (HC). METHODS: Transcriptional profile of GSE7890 which contained 5 normal scar with no HC treatment (NNHC), 4 normal scar treated with HC (NHC), 5 keloid with no HC treatment (KNHC) and 5 keloid treated with HC (KHC) samples was downloaded to identify differentially expressed genes (DEGs). Based on DEGs, hierarchical cluster analysis and pathway enrichment analysis were performed...
June 4, 2018: Journal of Dermatological Treatment
Rania Abdel Hay, Rehab Hegazy, Mohamed Abdel Hady, Noha Saleh
BACKGROUND: Combined azelaic acid (AA) and salicylic acid (SA) has not been previously used for acne. OBJECTIVE: To compare the efficacy of this combination versus trichloroacetic acid (TCA) 25% peel in acne. METHODS: 34 patients were included in this trial. Patients received four sessions two-weeks apart. The combined solution was applied to one side of the face while TCA was applied to the other. Our outcomes were physician-reported clinical improvement, dermoscopic assessment of the erythema and patient's satisfaction...
June 4, 2018: Journal of Dermatological Treatment
M Hughes, T Moore, J Manning, J Wilkinson, S Watson, P Samraj, G Dinsdale, C Roberts, L E Rhodes, A L Herrick, A Murray
BACKGROUND: Locally acting, well-tolerated treatments for systemic sclerosis (SSc) digital ulcers (DUs) are needed. OBJECTIVES: Our primary aim was to investigate the safety, feasibility and tolerability of a novel low level light therapy (LTTT). A secondary aim was to tentatively assess efficacy. METHODS: A custom-built device comprising infrared (850nm), red (660nm) and violet (405nm) LEDs was utilised. DUs were irradiated with 10J/cm2 twice weekly for three weeks, with follow-up at weeks 4&8...
June 4, 2018: Journal of Dermatological Treatment
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June 3, 2018: Journal of Dermatological Treatment
K P Nguyen, G J Knuiman, W A M Blokx, L Hoogedoorn, T Smits, M J P Gerritsen
BACKGROUND: Topical methyl aminolevulinate photodynamic therapy (MAL-PDT) is highly effective for the treatment of superficial basal cell carcinoma (sBCC). Current European treatment protocol requires two hospital visits, which is costly and unpractical. The aim of this study was to evaluate the efficacy of fractionated MAL-PDT, using two light fractions at 3 and 4 hours compared to illumination at 3 and 5 hours after MAL-application. METHODS: Thirty patients were randomized into two groups...
June 2, 2018: Journal of Dermatological Treatment
Rafael Silva Santos, Kahynna Loureiro, Polyana Rezende, Luciana Nalone, Raquel de Melo Barbosa, Antonello Santini, Ana Cláudia Santos, Classius F da Silva, Eliana Barbosa Souto, Damião Pergentino de Souza, Ricardo Guimarães Amaral, Patrícia Severino
Nanomedicine manipulates materials at atomic, molecular, and supramolecular scale, with at least one dimension within the nanometer range, for biomedical applications. The resulting nanoparticles have been consistently shown beneficial effects for antifungal drugs delivery, overcoming the problems of low bioavailability and high toxicity of these drugs. Due to their unique features, namely the small mean particle size, nanoparticles contribute to the enhanced drug absorption and uptake by the target cells, potentiating the therapeutic drug effect...
June 1, 2018: Journal of Dermatological Treatment
Hélène Roche, Kevin Bouiller, Eve Puzenat, Elise Deveza, Blandine Roche, Fabien Pelletier, Alison van de Laak, Anne Sophie Dupond, Charlée Nardin, François Aubin
BACKGROUND: Drug survival in a real-life setting is critical to long-term use of biologics for psoriasis. OBJECTIVE: We describe our 12-year experience with biologics in psoriasis patients. PATIENTS AND METHODS: All patients treated with biologics including infliximab, adalimumab, etanercept and ustekinumab for psoriasis vulgaris between January 2005 and December 2016 were retrospectively analyzed. RESULTS: In total, 545 treatment series were administered to 269 patients, including 211 treatment series with adalimumab, 135 with etanercept, 77 with infliximab and 122 with ustekinumab...
May 31, 2018: Journal of Dermatological Treatment
Erica B Lee, Mark G Lebwohl, Jashin J Wu
Crisaborole, a topical phosphodiesterase-4 (PDE4) inhibitor, is effective in patients with atopic dermatitis. As systemic PDE4 inhibition has also been used with success in psoriasis, clinical trials are underway to determine the utility of topical PDE4 inhibitors in these patients. However, there is no current literature documenting use of crisaborole for psoriasis. Here, we present two cases in which patients with psoriasis were treated successfully with crisaborole.
May 29, 2018: Journal of Dermatological Treatment
Einapak Boontaveeyuwat, Narumol Silpa-Archa, Nasuda Danchaivijitr, Chanisada Wongpraparut
BACKGROUND: Even though the traditional therapy for nail psoriasis has been used for decades, no randomized, controlled trial of such treatment has been conducted to date. OBJECTIVE: To evaluate the efficacy and safety of intralesional triamcinolone injections compared with 0.05% clobetasol ointment for psoriatic nails. MATERIALS AND METHODS: Psoriasis patients, each with three fingernails with similar degrees of severity, were randomly recruited for intralesional triamcinolone injection group, 0...
May 29, 2018: Journal of Dermatological Treatment
Vittorio Mazzarello, Marco Ferrari, Gabriella Piu, Valeria Pomponi, Giuliana Solinas
BACKGROUND: Research results on the efficacy of sunblock sticks in avoiding or reducing herpes labialis (HL) recurrences are contradictory and has shown mixed results, with some protection reported under experimental conditions that could not be replicated under natural conditions. OBJECTIVE: The purpose of the present work was to carry out an in vivo test on the effectiveness of a protective lip product in preventing recurrent HL in natural conditions during summer...
May 28, 2018: Journal of Dermatological Treatment
Mwangi J Murage, Amanda Anderson, Deborah Casso, Susan A Oliveria, Clement K Ojeh, Talia M Muram, Joseph F Merola, Art Zbrozek, Andre B Araujo
Abstrsct Purpose: Describe treatment patterns by disease severity among biologic-treated psoriasis patients. MATERIALS AND METHODS: We selected our study cohort in the IQVIA PharMetrics Plus adjudicated claims database linked to Electronic Health Record data from Modernizing Medicine Data Services. Patients were classified as having mild, moderate, or severe psoriasis based on a hierarchy of available severity measures. Patients were followed for 360 days to assess combination therapy, therapy switching and restarting, adherence and persistence...
May 25, 2018: Journal of Dermatological Treatment
Anish Nadkarni, Kimberly Hyde, Leah A Cardwell, Steven R Feldman
BACKGROUND: Biologics are a commonly used treatment for moderate to severe psoriasis. Monitoring laboratory test overuse provide little definitive benefit to patients. OBJECTIVE: We aim to query a Humana database to gain insight regarding current dermatologist laboratory monitoring practices for psoriasis patients on biologics. METHODS: Data were obtained from the Humana database. Our cohort included 333 patients with primary ICD-9 diagnosis of psoriasis (696...
May 24, 2018: Journal of Dermatological Treatment
A Firooz, H Hosseini, L Izadi Firouzabadi, M Nassiri Kashani, S A Nasrollahi
BACKGROUND: Cryotherapy using Wartner compound that contains a mixture of dimethyl ether (75%) and propane (25%) has been recently reported as an effective treatment for warts. The present study aimed to evaluate the safety and efficacy of Wartner in male patients with genital warts. METHODS: A Phase II parallel-randomized clinical trial was performed on 16 Iranian men affected by genital warts who were referred to a dermatology clinic at Tehran University of Medical Sciences...
May 23, 2018: Journal of Dermatological Treatment
Wei Wang, Ying Qiu, Fengying Zhao, Furen Zhang
BACKGROUND: The medication adherence of psoriasis patients may be influenced by a series combined internal and external factors. Effective methods for improving adherence could improve treatment outcomes. OBJECTIVE: To characterize medication adherence in psoriasis patients in China and to test an intervention to improve psoriasis patients' adherence. METHODS: We investigated 200 patients with psoriasis using questionnaires to determine their medication adherence and the factors that influence adherence...
May 23, 2018: Journal of Dermatological Treatment
Joshua S Mervis, Jean S McGee
The epigenetic regulation of gene expression is accomplished primarily through DNA methylation, histone modification, and gene silencing via the action of microRNAs. While previously very difficult to study, the field of epigenetics has been greatly facilitated by recent technological innovations. Alterations in the epigenome and epigenetic machinery are now known to be present in a variety of diseases, most notably cancers. Moreover, evidence has emerged that epigenetic dysregulation plays a causative role in disease pathogenesis...
May 22, 2018: Journal of Dermatological Treatment
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