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Journal of Dermatological Treatment

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https://www.readbyqxmd.com/read/28718676/selenium-zinc-copper-cu-zn-ratio-and-total-antioxidant-status-in-the-serum-of-vitiligo-patients-treated-by-narrow-band-ultraviolet-b-phototherapy
#1
Marta Wacewicz, Katarzyna Socha, Jolanta Soroczyńska, Marek Niczyporuk, Piotr Aleksiejczuk, Jolanta Ostrowska, Maria H Borawska
BACKGROUND: Vitiligo is a chronic, depigmenting skin disorder, which pathogenesis is still unknown. Narrow band ultraviolet-B is now one of the most widely used treatment of vitiligo. It was suggested that trace elements may play a role in pathogenesis of vitiligo. PURPOSE: The aim of this study was to estimate the concentration of selenium (Se), zinc (Zn), copper (Cu) and Cu/Zn ratio as well as total antioxidant status (TAS) in the serum of patients with vitiligo...
July 18, 2017: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/28678647/combination-of-benzoyl-peroxide-5-gel-with-liquid-cleanser-and-moisturizer-spf-30-in-acne-treatment-results-in-high-levels-of-subject-satisfaction-good-adherence-and-favorable-tolerability
#2
Mi-Ran Kim, Nabil Kerrouche
BACKGROUND: Skin care products (cleansers and moisturizers) to complement benzoyl peroxide (BPO) in the treatment of acne may improve treatment tolerability and adherence. OBJECTIVE: Evaluate subject satisfaction after use of BPO 5% gel in combination with liquid cleanser and moisturizer SPF 30. METHODS: Open-label study including subjects aged ≥12 years with mild-to-moderate facial acne; ClinicalTrials.gov Identifier: NCT02589405. Once daily BPO 5% gel, twice daily liquid cleanser and once daily moisturizer SPF 30 were applied for 12 weeks...
July 5, 2017: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/28678558/efficacy-of-cysteamine-cream-in-the-treatment-of-epidermal-melasma-evaluating-by-dermacatch-as-a-new-measurement-method-a-randomized-double-blind-placebo-controlled-study
#3
Susan Farshi, Parvin Mansouri, Behrooz Kasraee
BACKGROUND: Melasma is a difficult-to-treat hyperpigmentary disorder. Very few studies have been performed regarding the efficacy of cysteamine in the treatment of melasma. OBJECTIVE: To determine the efficacy of cysteamine cream in the treatment of patients with epidermal melasma using Dermacatch(®) as a more accurate skin colorimetric measurement tool. METHODS: Participating patients (n = 40) received either placebo (n = 20) or cysteamine cream (n = 20) in a double-blind placebo controlled study...
July 5, 2017: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/28670943/high-rates-of-secondary-non-adherence-causes-decreased-efficacy-of-0-1-topical-tacrolimus-in-adult-eczema-patients-results-from-a-multicenter-clinical-trial
#4
Min-Young Yang, Hyunju Jin, Woo-Haing Shim, Gun-Wook Kim, Hoon-Soo Kim, Hyun-Chang Ko, Hyo-Jin Kim, Ho-Seok Suh, Sook-Kyung Lee, So-Young Jung, Hye-Sook Kim, Kyung-Min Lim, Moon-Bum Kim, Byung-Soo Kim
BACKGROUND: Patients tend to apply topical medications less frequently, in improper amounts. Not only frequency but also application amount may influence treatment outcome. However, studies on relationship between application amount and objective treatment outcome have rarely been conducted. OBJECTIVE: To assess efficacy of topical agent according to application amount in adult patients, using the finger-tip unit method Methods: The efficacy of 0.1% topical tacrolimus in adult patients with localised atopic dermatitis was assessed using EASI, TIS, IGA, and PGA scores at baseline, follow-up...
July 3, 2017: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/28665169/morgellons-disease-experiences-of-an-integrated-multidisciplinary-dermatology-team-to-achieve-positive-outcomes
#5
Padma Mohandas, Anthony Bewley, Ruth Taylor
BACKGROUND: In recent years, there has been a reported increase in affliction of the skin with small fibres or other particles. The condition has been referred to as Morgellons disease. Patients present with stinging, burning or crawling sensations of the skin, with perceived extrusion of inanimate material alongside fatigue and other systemic symptoms. Sufferers often experience significant morbidity and reduction in quality of life. OBJECTIVES: We aimed to explore the various clinical presentations, management strategies and outcomes employed to treat this condition in our patients...
June 30, 2017: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/28627278/methotrexate-for-the-treatment-of-pediatric-alopecia-areata
#6
Erin T Landis, Rita O Pichardo-Geisinger
PURPOSE: Alopecia areata is a form of nonscarring hair loss that occurs in pediatric and adult patients, with presentation varying from round or ovoid patches of alopecia to alopecia totalis or universalis. While frustrating for patients, it can also be frustrating for clinicians to treat, as there is no definitive treatment. Dermatologists are very familiar with the use of methotrexate for psoriasis and other inflammatory skin diseases, and this medication is generally well tolerated in children...
June 30, 2017: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/28604229/review-the-reemergence-of-brachytherapy-as-treatment-for-non-melanoma-skin-cancer
#7
Koji Ota, Tony Adar, Laura Dover, Amor Khachemoune
Electronic brachytherapy (EBT) has seen a significant rise in use over the past few years in treating non-melanoma skin cancer (NMSC). However, the current literature in EBT remains scarce. Existing data on high-dose rate brachytherapy (HDR-BT) with surface applicators is often used to justify its efficacy and safety. In this review we study the two treatment modalities on their efficacy in treating NMSC and we explore the reasons behind the recent uprise in EBT. A literature review using PubMed was performed for articles published until January 2017 studying efficacy of HDR-BT and EBT for treating NMSC...
June 30, 2017: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/28660780/patients-with-male-gender-or-greater-body-weight-use-smaller-amounts-of-topical-therapy-in-psoriasis
#8
Minna E Kubin, Tero J W Pääkkö, Päivi M Hägg, Kaisa Tasanen, Riitta Palatsi
OBJECTIVES AND METHODS: Topical therapy is the first-line treatment in mild and moderate psoriasis. We performed a real-life study on topical therapies in psoriasis and observed a variation in the amounts of ointment patients applied during the study. RESULTS: A statistically significant correlation was found between gender and the total amount of ointment used: women used more than men (p = .020). Also, heavier patients tended to use less ointment (p = ...
June 29, 2017: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/28658998/patient-reported-outcomes-in-topical-field-treatment-of-actinic-keratosis-in-swedish-and-danish-patients
#9
Hanna Norrlid, Jenny M Norlin, Heidi Holmstrup, Irena Malmberg, Karin Sartorius, Henrik Thormann, Gregor B E Jemec, Gunnel Ragnarson Tennvall
Topical treatments in dermatology can be long, complex and lead to nonadherence and nonpersistence to prescribed treatment. Clinical efficacy observed in randomized clinical trials (RCT) may therefore be reduced in real-world clinical practice. The objective of this study was to analyze patient-reported treatment adherence, treatment satisfaction and health-related quality of life (HRQoL) with topical treatments of actinic keratosis (AK) in routine clinical practice in Denmark and Sweden. Adult patients prescribed field-directed topical AK treatments with diclofenac gel, imiquimod or ingenol mebutate per routine clinical practice were eligible for the observational RAPID-ACT study...
June 29, 2017: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/28609151/optimal-wound-care-management-in-hidradenitis-suppurativa
#10
Abrahem Kazemi, Kelly Carnaggio, Maureen Clark, Cynthia Shephard, Ginette A Okoye
INTRODUCTION: Hidradenitis suppurativa (HS) presents the problem of a chronic, relapsing, painful, draining wound. There is a myriad of HS wound care management strategies implemented by clinicians and patients centered around which dressings to use. Many factors affect which HS wound care dressing is the most appropriate to use such as the type of HS wound, cost, ease of application, patient comfort, absorbency and odor management among many others. AIM: In this work, the authors aim to prepare a set of guidelines for optimal HS wound care dressing use based on a tier system, ideal characteristics of HS dressings and the type of HS lesion...
June 29, 2017: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/28621164/effect-of-psoriasis-activity-and-topical-treatment-on-plasma-epidermal-growth-factor-egf-and-its-soluble-receptor-segfr
#11
M Szterling-Jaworowska, A Baran, H Myśliwiec, I Flisiak
BACKGROUND: Pathogenesis of psoriasis involves epidermal growth factor (EGF) which participates in keratinocyte proliferation, angiogenesis and cell differentiation through binding to soluble epidermal growth factor receptor (sEGFR). It is synthesised by, among others, keratinocytes, especially within psoriatic skin. OBJECTIVE: To evaluate EGF and sEGFR plasma concentrations during topical psoriatic treatment. METHODS: Blood samples were collected from 51 patients with plaque psoriasis...
June 16, 2017: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/28617145/defining-treatment-success-in-rosacea-as-clear-may-provide-multiple-patient-benefits-results-of-a-pooled-analysis
#12
Guy Webster, Martin Schaller, Jerry Tan, J Mark Jackson, Nabil Kerrouche, Gregor Schäfer
Background Rosacea treatment success is usually defined as a score of 1 ("almost clear") or 0 ("clear") on the 5-point Investigator Global Assessment (IGA) scale. Objective To evaluate whether after successful treatment, "clear" subjects had better outcomes than "almost clear" subjects. Methods A pooled analysis was performed on 1366 rosacea subjects from 4 randomized controlled trials with IGA before and after treatment (ivermectin, metronidazole or vehicle). Assessments included the Dermatology Life Quality Index (DLQI) questionnaire and subject assessment of rosacea improvement...
June 15, 2017: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/28521549/efficacy-of-topical-latanoprost-versus-minoxidil-and-betamethasone-valerate-on-the-treatment-of-alopecia-areata
#13
Amal Ahmad El-Ashmawy, Iman Hamed El-Maadawy, Gamal Mohamed El-Maghraby
BACKGROUND: Alopecia areata (AA) is one of the most common causes of localized hair loss. There is no universally proven therapy that induces and sustains remission of hair growth in AA. OBJECTIVE: To compare the efficacy and safety of topical latanoprost, minoxidil and betamethasone valerate on hair growth in patients with AA. PATIENTS AND METHODS: Hundred patients with AA classified into five groups of 20 treated with: Group I, latanoprost 0...
June 15, 2017: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/28609161/the-efficacy-of-short-term-clobetasol-lotion-in-the-treatment-of-scalp-psoriasis
#14
Ali Rajabi-Estarabadi, Hournaz Hasanzadeh, Arash Taheri, Steven R Feldman, Alireza Firooz
BACKGROUND: Scalp psoriasis can have a considerable impact on patients' quality of life and is considered difficult to treat. Treatment failure may, however, be due to poor adherence, as application of topical treatments to hair bearing areas is difficult and time consuming and also poor commination between physician and patient. OBJECTIVE: To assess the efficacy of short term treatment of scalp psoriasis with topical clobetasol lotion. MATERIALS AND METHODS: 12 patients with mild to severe scalp psoriasis were recruited for this study...
June 13, 2017: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/28608740/number-needed-to-treat-and-costs-per-responder-among-biologic-treatments-for-moderate-to-severe-plaque-psoriasis-in-japan
#15
Shinichi Imafuku, Ataru Nakano, Hidetoshi Dakeshita, Junlong Li, Keith A Betts, Annie Guerin
BACKGROUND: Biologics have been shown to improve the outcomes of patients with psoriasis but their cost is an issue. OBJECTIVE: Determine the number needed to treat (NNT) to achieve a 75%/90% reduction in the Psoriasis Area and Severity Index (PASI-75/90) and evaluate the incremental cost per PASI-75/90 responder (CPR) relative to placebo in Japan. METHODS: A network meta-analysis was conducted to estimate the relative probabilities of achieving PASI-75/90 and NNTs...
June 13, 2017: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/28608738/development-and-initial-psychometric-evaluation-of-patient-reported-outcome-questionnaires-to-evaluate-the-symptoms-and-impact-of-hidradenitis-suppurativa
#16
Alexa B Kimball, Murali Sundaram, Benjamin Banderas, Catherine Foley, Alan L Shields
BACKGROUND: Two patient-reported outcome (PRO) questionnaires, the Hidradenitis Suppurativa Symptom Assessment (HSSA) and Hidradenitis Suppurativa Impact Assessment (HSIA), were developed to measure signs, symptoms, and impacts of HS in treatment efficacy studies. METHODS: In accordance with FDA guidelines and published best practices, four stages of research were conducted to create the questionnaires: concept elicitation, questionnaire construction, content evaluation, and psychometric evaluation...
June 13, 2017: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/28604230/primary-cutaneous-post-liver-transplant-lymphoproliferative-disorder-ptld-successfully-treated-with-radiotherapy
#17
Aizuri Murad, Kieran Sheahan, Brian Kirby
A post liver transplant patient developed lesions with the clinical features suggestive of SCC-in-situ on his face and chest which occurred simultaneously since six months prior to his presentation. Skin histopathology confirmed the diagnosis of SCC-in-situ with additional plasmalymphocytic infiltrate in the dermis. Immunohistochemistry with his clinical presentation were in keeping with primary cutaneous post-transplant lymphoproliferative disorder (PTLD). He did not have any systemic involvement. Lesions were treated with radiotherapy with good response...
June 12, 2017: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/28604138/ehealth-technologies-as-an-intervention-to-improve-adherence-to-topical-antipsoriatics-a-systematic-review
#18
Mathias Tiedemann Svendsen, Flemming Andersen, Klaus Ejner Andersen
BACKGROUND: Topical antipsoriatics are recommended first-line treatment of psoriasis, but rates of adherence are low. Patient support by use of electronic health (eHealth) services is suggested to improve medical adherence. OBJECTIVE: To review randomised controlled trials (RCTs) testing eHealth interventions designed to improve adherence to topical antipsoriatics and to review applications for smartphones (apps) incorporating the word psoriasis. MATERIAL AND METHODS: Literature review: Medline, Embase, Cochrane, PsycINFO, and Web of Science were searched using search terms for eHealth, psoriasis and topical antipsoriatics...
June 12, 2017: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/28604133/a-preliminary-study-on-topical-cetirizine-in-the-therapeutic-management-of-androgenetic-alopecia
#19
A Rossi, D Campo, M C Fortuna, V Garelli, G Pranteda, D Di Nunno, M Carlesimo
Androgenetic alopecia (AGA) is a common form of scalp hair loss that affects up to 50% of males between 18-40 years old. Several molecules are commonly used for the treatment of AGA, acting on different steps of its pathogenesis (Minoxidil, Finasteride, Serenoa repens) and show some side effects. In literature, on the basis of hypertrichosis observed in patients treated with analogues of prostaglandin PGF2α, was supposed that prostaglandins would have an important role in the hair growth: PGE and PGF2α play a positive role, while PGD2 a negative one...
June 12, 2017: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/28604132/the-efficacy-of-methotrexate-in-the-treatment-of-en-coup-de-sabre-linear-morphea-subtype
#20
Ploysyne Rattanakaemakorn, Joseph Jorizzo
BACKGROUND: En coup de sabre is a rare subtype of linear morphea, located on the forehead or frontoparietal scalp. Systemic treatment of localized morphea with methotrexate has been reported in a few clinical reports. However, there are no case series using methotrexate treatment for En coup de sabre. OBJECTIVE: To evaluate the efficacy and tolerability of methotrexate in the treatment of en coup de sabre linear morphea subtype. METHOD: A retrospective chart review was performed for pediatric and the adult patients with en coup de sabre evaluated in the Dermatology Clinic at Wake Forest University School of Medicine treated with methotrexate...
June 12, 2017: Journal of Dermatological Treatment
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