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Journal of Dermatological Treatment

Yossi Taieb, Sharon Baum, Dan Ben Amitai, Aviv Barzilai, Shoshana Greenberger
BACKGROUND: Atopic dermatitis is a chronic inflammatory skin disease. Methotrexate is an off-label systemic agent for treating uncontrolled atopic dermatitis. OBJECTIVE: This study assessed the safety and efficacy of methotrexate in pediatric patients with atopic dermatitis. METHODS: This multicenter, retrospective study assessed pediatric patients with atopic dermatitis who were treated with methotrexate. RESULTS: Medical records of 26 pediatric patients with atopic dermatitis were reviewed...
August 15, 2018: Journal of Dermatological Treatment
Hua-Ching Chang, Chih-Wei Sung, Ming-Hsiu Lin
BACKGROUND: Acyclovir has been reported as a potential therapy for pityriasis rosea (PR) in several clinical trials on the basis of evidence of the involvement of human herpes viruses 6 and 7. OBJECTIVE: We evaluated the efficacy of acyclovir for abating PR skin lesions within a fixed period. METHODS: We searched 4 databases for clinical trials that used oral acyclovir to treat PR and performed systematic review and meta-analysis to determine oral acyclovir's effect on skin lesions at the 14th day after commencing treatment...
August 15, 2018: Journal of Dermatological Treatment
Inge M G J Bronckers, Maartje J van Geel, Peter C M van de Kerkhof, Elke M G J de Jong, Marieke M B Seyger
BACKGROUND: Psoriasis can have a substantial impact on health-related quality of life(HRQoL), life course and work productivity. Young adulthood is a critical, sensitive period of development that includes major life changing decisions. The impact of psoriasis on this vulnerable population is yet unknown. OBJECTIVES: To assess QoL, life course and work productivity in young adults with psoriasis and identify characteristics influencing these patient-reported outcomes(PRO)...
August 13, 2018: Journal of Dermatological Treatment
Min Diao, Christina Thapa, Xin Ran, Yuping Ran, Xiaoyan Lv
BACKGROUND: Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare drug-related life-threatening acute conditions. Infection is a major cause of morbidity and mortality in these patients. The aim of this study was to analyze the infective characteristics and antimicrobial strategies in patients with Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN). METHODS: 125 patients who were diagnosed with SJS/TEN in West China Hospital from 2010 to 2017 were retrospectively analyzed...
August 10, 2018: Journal of Dermatological Treatment
Mina Amin, Erica B Lee, Jashin J Wu
No abstract text is available yet for this article.
August 8, 2018: Journal of Dermatological Treatment
Jordan M Keeley, Stephanie L Bevans, Tarannum Jaleel, Naveed Sami
OBJECTIVES: This pilot retrospective study examined the role of continuous low-dose maintenance immunomodulatory treatment (IMT) as an adjunct to rituximab (RTX) rescue therapy in severe pemphigus vulgaris and pemphigus foliaceus after a complete response (CR) to RTX was achieved. MATERIALS AND METHODS: Ten severe pemphigus patients who received RTX rescue therapy were evaluated after achieving complete response. The post-RTX clinical course and long-term follow up was compared between patients who adhered to a low recommended dose (LRMD) to patients who were non-compliant with LRMD...
August 8, 2018: Journal of Dermatological Treatment
Seung Yeon Song, Sun-Young Jung, Eun Young Kim
Objective The aim of this study was to assess steroid phobia among general users of topical corticosteroids and to analyze factors associated with steroid phobia. Methods A cross-sectional nationwide survey was conducted using an online panel with participants stratified by age, sex, and region. Those aged 18-65 years with experience of topical steroid use within the past 1 year were included. Results Of the 3000 respondents included, 929 (31%) had steroid phobia. Among those with steroid phobia, 322 (35%) reported that their fear developed after obtaining information from the media...
August 6, 2018: Journal of Dermatological Treatment
Essam Bakr Abd El-Aal, Hamed Abdou, Shady Mahmoud Ibrahim, Mostafa Taha Eldestawy
BACKGROUND: Onychomycosis is a chronic fungal infection of the nails and the treatment has been proven to be a challenge to healthcare professionals. OBJECTIVE: To evaluate the efficacy of fractional carbon dioxide laser assisted delivery of topical tazarotene versus topical tioconazole in the treatment of onychomycosis. METHODS & MATERIALS: A total of 102 patients with onychomycosis were randomly assigned to groups A and B, both groups were treated with 4 sessions of fractional CO2 laser and followed by topical tazarotene 0...
August 6, 2018: Journal of Dermatological Treatment
Ling Liu, Yan Wu, Jianzhong Zhang, Heng Gu, Qi Luan, Linhan Qian, Yanting Wang, Lin Gao, Hongyi Wang, Bihuan Xiao, Yan Sun, Houmin Li, Kun Chen, Fanqin Zeng, Chunying Li, Tianwen Gao, Xing-Hua Gao
BACKGROUND: Acral vitiligo often responses poorly to treatments. OBJECTIVE: To observe whether pre-treatment with ablative fractional CO2 laser aiding penetration of compound betamethasone solution plus NB-UVB could improve response of refractory acral vitiligo. METHODS: Subjects with symmetrical and stable acral vitiligo were enrolled in this study. The symmetrical lesions were randomly allocated into experimental and control sides in a subject...
August 6, 2018: Journal of Dermatological Treatment
Kamran Balighi, Maryam Daneshpazhooh, Zahra Akbari, Soheil Tvakolpour, Pourya Azimi, Arghavan Azizpour
INTRODUCTION: Rituximab is a recent treatment in recalcitrant pemphigus vulgaris (PV) patients; This study aims to establish the optimal time for rituximab therapy in PV patients. METHODS: In this retrospective study patients who received rituximab within six months of diagnosis were classified as the early treatment group, and patients who have received it later than six months were classified as the delayed treatment group. RESULTS: ninety-five PV patients were reviewed...
August 6, 2018: Journal of Dermatological Treatment
Hao Feng, Jeffrey M Cohen, Andrea L Neimann
PURPOSE: Injectable biologics (IB) are important in dermatology and we sought to examine the distribution of U.S. IB-prescribing dermatologists. MATERIALS AND METHODS: We used Centers for Medicare and Medicaid Services Medicare Provider Utilization and Payment Data: Part D for 2013-2015. Density of dermatologists who prescribe IB (etanercept, adalimumab, ustekinumab, secukinumab) in each U.S. county, represented as number of dermatologists per 100,000 Medicare Part D beneficiaries, was calculated...
August 4, 2018: Journal of Dermatological Treatment
Matteo Megna, Alessia Villani, Nicola Balato, Anna Balato
No abstract text is available yet for this article.
August 4, 2018: Journal of Dermatological Treatment
S C A Hanssen, C J M van der Vleuten, P E J van Erp, M M B Seyger, P C M van de Kerkhof
BACKGROUND: Vascular proliferation is considered an important feature in psoriasis. Early psoriatic changes are characterized by vascular network expansion; healing of the lesions ultimately results in a decreasing size of the vascular network. Currently, the response of the vasculature in psoriatic lesions during treatment of adalimumab is still obscure. OBJECTIVE: To investigate the response of the vasculature in psoriatic lesions during adalimumab treatment, using parameters such as endothelial cell proliferation, vascular network size and alternations in vessel diameter...
August 3, 2018: Journal of Dermatological Treatment
Mina Amin, Erica B Lee, Tina Bhutani, Jashin J Wu
BACKGROUND: Patient registries are databases that contain clinical data for patients with a specific disease or medical condition. OBJECTIVE: The purpose was to identify psoriasis registries in Europe and examine their characteristics and implications. METHODS: We searched Google, the Registry of Patient Registries, and to generate a list of European psoriasis registries. We also conducted a literature review for publications related to the psoriasis registries in Europe using PubMed...
July 27, 2018: Journal of Dermatological Treatment
Fatima McKenzie, Devin Cash, Angela Gupta, Laurel W Cummings, Alex Ortega-Loayza
Pyoderma gangrenosum (PG) is an uncommon inflammatory skin disorder characterized by neutrophil dysfunction. There are currently no FDA approved drugs for the treatment of this disease, and treatment has typically relied on traditional immunosuppressive medications such as prednisone or cyclosporine. The efficacy of biologics in the treatment of other pro-inflammatory conditions such as psoriasis, rheumatoid arthritis, and inflammatory bowel disease is well-documented in the literature. Therefore, the use of biologic medications for the treatment of rarer inflammatory skin conditions, such as PG, is a compelling topic for investigation...
July 27, 2018: Journal of Dermatological Treatment
Ros Wade, Julie Jones-Diette, Kath Wright, Alison M Layton, Nerys Woolacott
PURPOSE: To identify the tools that have been used to measure quality of life in hyperhidrosis research and obtain patient insight on commonly used tools. METHODS: Twelve databases were searched to identify studies that reported measuring quality of life or described a quality of life tool in the context of hyperhidrosis. Data on the use of the tools were tabulated and hyperhidrosis-specific and dermatology-specific measures were summarised. A workshop was held to obtain the patients' perspective on the most commonly used tools and the newly developed HidroQoL© tool...
July 27, 2018: Journal of Dermatological Treatment
Therezia Bokor-Billmann, Knut Schäkel
BACKGROUND: Regarding treatment of psoriasis, dermatologists now use new, highly effective targeted therapies. Among such, biologic therapies have become a mainstay in patients with moderate to severe psoriasis; yet a substantial proportion of patients show insufficient or no treatment response. Current literature has insufficient evidence for successful treatment when switching biologics after multiple failures, in particular when the biologics share a common mechanism of action, is scarce...
July 27, 2018: Journal of Dermatological Treatment
Ali Abdul Hussein S Al-Janabi, Abass M Bashi
BACKGROUND: Dermatophytes, which are a common causative agents of superficial infection on the human skin, can be treated by various antifungal drugs. Nanoparticles composed of such drugs have many benefits. A new form called xerogel of silver and zinc oxide nanoparticles was prepared and tested against dermatophytes. METHODS: Xerogel formed of silver nanoparticles (Ag-NPs) and zinc oxide nanoparticles (ZnO-NPs) was prepared. Characteristics of chemical composition, surface morphology, and nanoparticle size were determined...
July 27, 2018: Journal of Dermatological Treatment
Georgios Kravvas, David Veitch, Firas Al-Niaimi
BACKGROUND: Striae distensae are caused by rapid stretching of the skin. They are often secondary to obesity or pregnancy, and can lead to significant cosmetic disfigurement. AIM: To determine the efficacy, indications, and side effects of commonly used energy devices in the treatment of striae. METHODS: A comprehensive literature search was performed using the PubMed and Medline databases. RESULTS: A total of 41 relevant articles were identified...
July 27, 2018: Journal of Dermatological Treatment
Issam Hamadah, Muzamil A Chisti, Mansoor Haider, Yousef Binamer, Saad Alajlan, Yousif Aleyouni, Abdullah Alfadley
BACKGROUND: Pemphigus is a chronic potentially life-threatening autoimmune blistering disease affecting the skin and/or mucous membranes. Rituximab is being increasingly used and found efficacious in the treatment of pemphigus. OBJECTIVE: To present the Middle-Eastern experience with the use of rituximab in pemphigus. METHODS: A retrospective analysis of patient files was conducted which revealed 23 patients of pemphigus who were treated with rituximab (either alone or with IVIG) in the dermatology department of a tertiary care hospital from July 2004 to December 2014...
July 27, 2018: Journal of Dermatological Treatment
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