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Journal of Dermatological Treatment

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https://www.readbyqxmd.com/read/28817990/using-qualitative-methods-to-understand-factors-contributing-to-patient-satisfaction-among-dermatology-patients-a-systematic-review
#1
Caitlin Gibbons, Sanminder Singh, Brittany Gibbons, Caitlin Clark, Josefina Torres, Michelle Y Cheng, Elizabeth A Wang, April W Armstrong
PURPOSE: In this systematic review, we aimed to synthesize data that identify factors contributing to patient satisfaction in dermatology care using qualitative methods. MATERIALS AND METHODS: We performed a comprehensive search of the literature using the PubMed database for articles published between January 1, 2000 and February 9, 2015. The initial search yielded 186 articles, of which 13 were included after applying inclusion and exclusion criteria. RESULTS: The systematic review of 13 articles included a total of 330 patients...
August 18, 2017: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/28814117/review-of-the-mechanism-of-action-of-coal-tar-in-psoriasis
#2
Sahil Sekhon, Caleb Jeon, Mio Nakamura, Ladan Afifi, Di Yan, Jashin Wu, Wilson Liao, Tina Bhutani
Crude coal tar and its derivatives have been used in modern medicine for the treatment of psoriasis since at least 1925 as part of the Goeckerman regimen. To this day, coal tar remains a safe and highly effective option for the treatment of psoriasis vulgaris. However, the mechanism by which coal tar has its therapeutic effect is not known. This review summarizes current knowledge of the mechanism by which coal tar has its therapeutic effect in the treatment of psoriasis vulgaris.
August 17, 2017: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/28506134/efficacy-and-safety-of-etanercept-in-psoriasis-and-psoriatic-arthritis-in-the-presta-study-analysis-in-patients-from-central-and-eastern-europe
#3
Nemanja Damjanov, Sarolta Karpati, Lajos Kemeny, Noemi Bakos, Branislav Bobic, Maria Majdan, Witold Tlustochowicz, Petr Vitek, Eva Dokoupilova, Emre Aldinc, Annette Szumski
BACKGROUND: Data are limited on the effectiveness of anti-TNF and other biologics on psoriatric arthritis (PsA) in Central and Eastern Europe (CEE). The objective of this analysis was to evaluate the efficacy of etanercept (ETN) in PsA patients from CEE. METHODS: In PRESTA, patients were randomized to receive ETN 50 mg BIW or 50 mg QW for 12 weeks (double-blind phase) and ETN 50 mg QW for 12 additional weeks (open label). In this analysis, only patients from Czech Republic, Hungary, Poland and Serbia were included...
August 16, 2017: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/28797188/validation-of-psychometric-properties-and-development-of-response-criteria-for-the-psoriasis-symptoms-and-signs-diary-pssd-results-from-a-phase-iii-clinical-trial
#4
April Armstrong, Luis Puig, Richard Langley, Tsen Fang Tsai, Michael Song, Yasmine Wasfi, Jingzhi Jiang, Shu Li, Chenglong Han
PURPOSE: The Psoriasis Symptoms and Signs Diary (PSSD) is a patient-reported instrument that assesses severity of six psoriasis symptoms (itch, skin tightness, burning, stinging, and pain,) and five signs (dryness, cracking, scaling, shedding/flaking, redness, and bleeding). MATERIALS AND METHODS: PSSD symptoms and signs summary scores (0-100) were derived based on individual item scores (0-10 [absent-worst imaginable]). Using Psoriasis Area and Severity Index [PASI], Investigator's Global Assessment [IGA] and Dermatology Life Quality Index [DLQI]) data from the NAVIGATE trial of patients with moderate-to-severe psoriasis, analyses were conducted to further validate the PSSD (7-day recall version) and establish criteria for clinically meaningful improvements (CMIs)...
August 11, 2017: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/28792259/improvements-in-psoriasis-within-different-body-regions-vary-over-time-following-treatment-with-ixekizumab
#5
Andrew Blauvelt, Talia M Muram, Kyoungah See, Craig H Mallinckrodt, Jeffrey J Crowley, Peter van de Kerkhof
BACKGROUND: Ixekizumab is a high-affinity monoclonal antibody that selectively targets interleukin-17A. OBJECTIVE: Examine the efficacy of ixekizumab in clearing psoriasis within different body regions. METHODS: Data from 3 placebo- (PBO) or PBO- and etanercept (ETN)-controlled trials were integrated. Patients with moderate-to-severe psoriasis were randomized to 12 weeks of PBO (UNCOVER-1, -2, -3, N = 792; UNCOVER-2, -3, N = 361), 50 mg ETN twice weekly (N = 740), or 80 mg ixekizumab every 2 (IXE Q2W; N = 1169; N = 736) or 4 weeks (IXE Q4W; N = 1165; N = 733) after a 160-mg starting dose...
August 9, 2017: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/28789582/long-term-drug-survival-and-predictor-analysis-of-the-whole-psoriatic-patient-population-on-biological-therapy-in-hungary
#6
Lilla Pogácsás, András Borsi, Péter Takács, Éva Remenyik, Lajos Kemény, Sarolta Kárpáti, Péter Holló, Norbert Wikonkál, Rolland Gyulai, Zsuzsanna Károlyi, Pál Rakonczai, Tamás Balázs, Andrea Szegedi
Persistence is an important component of therapeutic success, which depends on a variety of factors. Persistence measured under optimal conditions during clinical trials does not necessarily coincide with persistence observed in the real-world settings. The aim of the present study was to compare persistence rate of TNF-alpha inhibitors and interleukin 12/23 inhibitor in all psoriasis patients in Hungary, as well as to analyze the predictors of persistence. Data collected from 1263 patients over a period of 46 months were subjected to a retrospective analysis...
August 9, 2017: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/28789577/utility-of-boron-in-dermatology
#7
David G Jackson, Leah A Cardwell, Elias Oussedik, Steven R Feldman
INTRODUCTION: Boron compounds are being investigated as therapies for dermatologic conditions. Several features of boron chemistry make this element an ideal component in dermatologic treatments. We review the published dermatologically-relevant clinical trials and case studies pertaining to boron compounds. METHODS: PubMed was utilized to query terms boron, chemistry, drug, development, dermatology, atopic dermatitis, psoriasis, onychomycosis, tavaborole, AN 2690, crisaborole, and AN 2728...
August 9, 2017: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/28789575/prescriptions-for-atopic-dermatitis-oral-corticosteroids-remain-commonplace
#8
Tiffany Alexander, Elena Maxim, Leah A Cardwell, Aneesh Chawla, Steven R Feldman
INTRODUCTION: Atopic dermatitis (AD) is a common, chronic inflammatory skin disease characterized by pruritic, often lichenified, patches and plaques. METHODS: Data were obtained from the Humana database, a large claims-based database encompassing more than 20 million patients under a commercial healthcare insurance plan. Our cohort included 39,526 subjects who saw a dermatologist for a primary ICD-9 diagnosis of atopic dermatitis (691.8) between the years of 2010-2015...
August 9, 2017: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/28784003/wide-range-of-age-of-onset-and-low-referral-rates-to-psychiatry-in-a-large-cohort-of-acne-excori%C3%A3-e-at-a-swiss-tertiary-hospital
#9
Florian Anzengruber, Katrin Ruhwinkel, Adhideb Ghosh, Richard Klaghofer, Undine E Lang, Alexander A Navarini
INTRODUCTION: Repetitive skin manipulation is the key symptom in skin picking disorder (SPD), or acne excoriée des jeunes filles Brocq. The diagnostic and statistical manual of mental disorders (DSM-5) has recognized SPD as an independent disease, namely an obsessive-compulsive disorder. Thus, psychiatric treatment is indicated. Therefore, in a large cohort of SPD, we asked whether dermatologists' treatment strategy includes routine referrals to psychiatry. In addition, we describe epidemiological data, treatments and follow up...
August 8, 2017: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/28784002/secukinumab-is-the-most-efficient-treatment-for-achieving-clear-skin-in-psoriatic-patients-a-cost-consequence-study-from-the-spanish-national-health-service
#10
Lluís Puig, Jaume Notario, Alberto Jiménez-Morales, Moreno-Ramírez David, Anna Lopez-Ferrer, Irmina Gozalbo, Míriam Prades, Luís Lizán, Carles Blanch
OBJECTIVE: To compare the cost-consequence of biologic drugs for moderate-severe psoriasis from the perspective of the Spanish National Health System. METHODS: We built a decision tree with a 2-year time horizon. Efficacy data for biologics (etanercept, infliximab, adalimumab, ustekinumab and secukinumab) was drawn from published meta-analyses: PASI75 for the induction phase and PASI90 for the rest of follow-up. Patients with PASI < 75 at week 10-16 were switched to another biologic agent...
August 8, 2017: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/28783991/effectiveness-of-etanercept-in-children-with-plaque-psoriasis-in-real-practice-a-one-year-multicentre-retrospective-study
#11
V Di Lernia, C Guarneri, L Stingeni, P Gisondi, D Bonamonte, P G Calzavara Pinton, A Offidani, K Hansel, G Girolomoni, A Filoni, A Belloni Fortina, E Ficarelli, S P Cannavò
Background Etanercept is licensed for the treatment of moderate-to-severe plaque psoriasis in children. Objectives The aim of this analysis was to investigate effectiveness, tolerability and reasons for discontinuation of etanercept in a real-life cohort of children and adolescents with moderate to severe plaque psoriasis. Methods Data collected from a number of centers belonging to the "Pediatric Dermatology Group" of the Italian Society of Dermatology (SIDeMaST) were examined in patients (age ≤ 17 years) who started treatment with etanercept from 2011 to 2015...
August 8, 2017: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/28783990/prospects-of-topical-protection-from-ultraviolet-radiation-exposure-a-critical-review-on-the-juxtaposition-of-the-benefits-and-risks-involved-with-the-use-of-chemoprotective-agents
#12
Nilutpal Sharma Bora, Bhaskar Mazumder, Pronobesh Chattopadhyay
Solar ultraviolet (UV) radiation exposure is known to cause inevitable damage to human skin via different mechanisms which include disruption of genetic material and generation of free radicals. In the ever emerging field of photoprotective agents, there have been constant endeavors to uphold the standards for optimum protection from solar UV induced damages which include alarming conditions ranging from severe keratosis to malignant transformation of skin cells. Out of the various methods available for photoprotection, chemical photoprotective agents are most popular due to its ease of applicability, availability and efficacy...
August 8, 2017: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/28783420/prescription-level-factors-associated-with-primary-nonadherence-to-dermatologic-medications
#13
Audrey Rutherford, Donald A Glass, Elizabeth A Suarez, Adewole S Adamson
PURPOSE: To analyze factors associated with primary nonadherence to dermatologic medications and study whether prescription-level factors are associated with primary nonadherence. MATERIAL AND METHODS: A retrospective review of medical records of new dermatology patients from January 2011 to December 2013 at a single urban safety-net hospital outpatient dermatology clinic with a closed pharmacy system. RESULTS: A total of 4307 prescriptions were written for 2490 patients...
August 7, 2017: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/28782438/use-of-moisturizers-among-danish-atopic-dermatitis-patients-which-perceived-product-characteristics-associate-with-long-term-adherence
#14
Kristina Melbardis Jorgensen, Gregor B E Jemec
PURPOSE: To identify factors perceived as most important regarding choice and continued use of moisturizers for adult patients with AD. METHOD AND MATERIALS: Online survey among members of the Atopic dermatitis society Denmark. RESULTS: Among 75 participants, the most commonly tried (89,3%) and preferred (16%) product was Locobase® (Leo Pharma, Denmark). A-derma® (Pierre Fabre, France) had most continued use. Main reason for choosing preferred product was 'Best effect, in my experience' (36%)...
August 7, 2017: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/28782389/the-effect-of-phototherapy-on-progression-to-tumors-in-patients-with-patch-and-plaque-stage-of-mycosis-fungoides
#15
Joyce W Hoot, Li Wang, Terry Kho, Oleg E Akilov
BACKGROUND: Phototherapy has been a mainstay in the treatment of mycosis fungoides (MF). However, the recent findings of UV-induced p53 mutations in advanced MF suggest that phototherapy may contribute to disease progression. OBJECTIVE: The objective of this study was to evaluate the effect of phototherapy on the time to tumor progression and overall survival in MF. MATERIALS AND METHODS: Retrospective analysis of patients seen at the University of Pittsburgh Cutaneous Lymphoma Clinic from 1979 to 2016...
August 7, 2017: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/28782384/skin-microneedling-plus-platelet-rich-plasma-versus-skin-microneedling-alone-in-the-treatment-of-atrophic-post-acne-scars-a-split-face-comparative-study
#16
Mohamed Kotb, Shady Mahmoud Ibrahim
INTRODUCTION: Acne scarring is a permanent disfiguring sequel, which can take varied morphological forms. Many therapeutic measures have been performed to improve acne scarring such as microneedling. Our objective is to evaluate the efficacy and safety of microneedling alone versus microneedling in combined with platelet rich plasma in the treatment of post acne Methods: The study included 35 patients with mild to severe post acne atrophic scar. All the patients received four sequential treatments of skin microneedling alone on the right side of the face and skin microneedling followed by topical application of PRP on the left side of the face with an interval of 3 weeks...
August 7, 2017: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/28777015/is-weekly-dose-of-adalimumab-a-simple-approach-for-resistant-psoriasis
#17
Sara Mazzilli, Arianna Zangrilli, Mauro Bavetta, Luca Bianchi
Backgroud: In real life, dose escalation can be a good approach for increasing efficacy in a subgroup of patients with an insufficient response to biologic therapy, reducing the signs and symptoms of psoriasis and improving the quality of life (QOL). OBJECTIVE: To determine the effectiveness of escalating adalimumab dosage from 40 mg eow to 40 mg weekly in a patient affected by psoriasis (PsO) and psoriatic arthritis (PsA) with < PASI 50 response following 364 weeks treatment...
August 4, 2017: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/28718676/selenium-zinc-copper-cu-zn-ratio-and-total-antioxidant-status-in-the-serum-of-vitiligo-patients-treated-by-narrow-band-ultraviolet-b-phototherapy
#18
Marta Wacewicz, Katarzyna Socha, Jolanta Soroczyńska, Marek Niczyporuk, Piotr Aleksiejczuk, Jolanta Ostrowska, Maria H Borawska
BACKGROUND: Vitiligo is a chronic, depigmenting skin disorder, whose pathogenesis is still unknown. Narrow band ultraviolet-B (NB-UVB) is now one of the most widely used treatment of vitiligo. It was suggested that trace elements may play a role in pathogenesis of vitiligo. AIM: The aim of this study was to estimate the concentration of selenium (Se), zinc (Zn), copper (Cu) and Cu/Zn ratio as well as total antioxidant status (TAS) in the serum of patients with vitiligo...
August 1, 2017: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/28753097/mometasone-furoate-in-the-treatment-of-vulvar-lichen-sclerosus-could-its-formulation-influence-efficacy-tolerability-and-adherence-to-treatment
#19
Monica Corazza, Annarosa Virgili, Giulia Toni, Alessandro Borghi
Purpose To assess the effectiveness, tolerability and convenience of the cream formulation of mometasone furoate 0.1% (MMF) in the treatment of active vulvar lichen sclerosus (VLS) and to compare the cream with the ointment formulation. Methods The following efficacy parameters were assessed in 27 VLS patients treated with MMF cream for 12 weeks (group A): i) response rate, ii) percentage of patients achieving an improvement from baseline of ≥75% in subjective and objective scores, iii) mean reduction in subjective and objective scores...
July 28, 2017: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/28753055/the-association-of-isoconazole-diflucortolone-in-the-treatment-of-paediatric-tinea-corporis
#20
Stefano Veraldi, Rossana Schianchi, Paolo Pontini, Alberto Gorani
BACKGROUND: Tinea corporis is a common mycotic infection in children. Staphylococcus aureus superinfections may be observed in atopic children with tinea corporis suffering from severe pruritus and consequent scratching. OBJECTIVE: From 2006 to 2011, we observed 288 children with mycologically proven tinea corporis. In 39 of them (13.5%) tinea corporis was superinfected by S. aureus: all these children were affected by atopic dermatitis. We interpreted these bacterial superinfections as the clinical result of scratching due to pruritus...
July 28, 2017: Journal of Dermatological Treatment
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