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American Journal of Respiratory Cell and Molecular Biology

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https://www.readbyqxmd.com/read/29768017/the-signaling-network-resulting-in-ventilator-induced-diaphragm-dysfunction
#1
Huibin Tang, Joseph B Shrager
Mechanical ventilation (MV) is a life-saving measure for those incapable of adequately ventilating or oxygenating without assistance. Unfortunately, even brief periods of MV result in diaphragm weakness (i.e., "ventilator-induced diaphragm dysfunction" - VIDD) that may render it difficult to wean the ventilator. Prolonged MV is associated with cascading complications and is a strong risk factor for death. Thus, prevention of VIDD may have a dramatic impact on mortality rates. Here, we summarized the current understanding of the pathogenic events underlying VIDD...
May 16, 2018: American Journal of Respiratory Cell and Molecular Biology
https://www.readbyqxmd.com/read/29767533/sirt1-controls-poly-i-c-dependent-mmp9-activation-in-primary-human-nasal-epithelial-cells
#2
Masanobu Suzuki, Mahnaz Ramezanpour, Clare Cooksley, Jian Li, Yuji Nakamaru, Akihiro Homma, Alkis Psaltis, Peter-John Wormald, Sarah Vreugde
BACKGROUND: Matrix metalloproteinase 9 (MMP9) is thought to be involved in the etiopathogenesis of chronic rhinosinusitis with nasal polyps (CRSwNP) and cleaves collagen IV causing hyperpermeability of the basement membrane within mucosal tissue. It is known that MMP9 expression is negatively affected by sirtuin-1 (SIRT-1) in human monocytotic cells, retinal endothelial cells and epithelial carcinoma cells. However, it is unknown which factors affect MMP9 expression and activity in human nasal epithelial cells (HNECs)...
May 16, 2018: American Journal of Respiratory Cell and Molecular Biology
https://www.readbyqxmd.com/read/29757677/microrna-dysregulation-in-pulmonary-arteries-from-copd-relationships-with-vascular-remodeling
#3
Melina M Musri, Núria Coll-Bonfill, Bradley A Maron, Víctor I Peinado, Ruisheng Wang, Jordi Altirriba, Isabel Blanco, William M Oldham, Olga Tura-Ceide, Jessica García-Lucio, Benjamin de la Cruz-Thea, Gunter Meister, Joseph Loscalzo, Joan A Barberà
BACKGROUND: Pulmonary vascular remodeling is an angiogenic-related process involving changes in smooth muscle cell (SMC) homeostasis, which is frequently observed in chronic obstructive pulmonary disease (COPD). MicroRNAs (miRNAs) are small non-coding RNAs that regulate mRNA expression levels of many genes leading to the manifestation of cell identity and specific cellular phenotypes. Here we evaluate the miRNA expression profiles of pulmonary arteries (PA) of patients with COPD and its relationship with the regulation of SMC phenotypic change...
May 14, 2018: American Journal of Respiratory Cell and Molecular Biology
https://www.readbyqxmd.com/read/29723043/spdefending-the-lung-through-mucin-expression
#4
Christopher M Evans, Max A Seibold, Anthony N Gerber
No abstract text is available yet for this article.
May 3, 2018: American Journal of Respiratory Cell and Molecular Biology
https://www.readbyqxmd.com/read/29723038/the-gut-lung-axis-and-pulmonary-responses-to-ozone
#5
Judith A Voynow, Karen D Hendricks-Muñoz
No abstract text is available yet for this article.
May 3, 2018: American Journal of Respiratory Cell and Molecular Biology
https://www.readbyqxmd.com/read/29723035/targeting-interleukin-8-in-cystic-fibrosis-enough-but-not-too-much
#6
Oliver J McElvaney, Noel G McElvaney
No abstract text is available yet for this article.
May 3, 2018: American Journal of Respiratory Cell and Molecular Biology
https://www.readbyqxmd.com/read/29708399/il-17-strikes-a-chord-in-copd-exacerbation
#7
Helen E Rich, John F Alcorn
No abstract text is available yet for this article.
April 30, 2018: American Journal of Respiratory Cell and Molecular Biology
https://www.readbyqxmd.com/read/29708395/the-emerging-role-of-neutrophils-in-repair-after-acute-lung-injury
#8
Jorge Blázquez-Prieto, Inés López-Alonso, Covadonga Huidobro, Guillermo M Albaiceta
Neutrophils are key players in acute lung injury. Once recruited from the circulation, these cells release cytotoxic molecules that lead to tissue disruption, so their blockade has been advocated to prevent lung damage. However, lung injury also occurs during neutropenia, and usually involves a very poor outcome. There is emerging evidence that neutrophils not only contribute to that early damage, but also orchestrate later repair. Neutrophils promote epithelial proliferation and are a source of proteases, which are required for the processing of the collagen scar and facilitation of cell migration...
April 30, 2018: American Journal of Respiratory Cell and Molecular Biology
https://www.readbyqxmd.com/read/29708393/models-of-ciliary-dysfunction-time-to-expand
#9
Amelia Shoemark
No abstract text is available yet for this article.
April 30, 2018: American Journal of Respiratory Cell and Molecular Biology
https://www.readbyqxmd.com/read/29708392/can-we-manipulate-the-evolutionary-biology-of-pathogens-for-clinical-benefit
#10
Craig Winstanley, Michael A Brockhurst
No abstract text is available yet for this article.
April 30, 2018: American Journal of Respiratory Cell and Molecular Biology
https://www.readbyqxmd.com/read/29698616/mitigating-lung-fibrosis-by-targeting-dysfunctional-alveolar-epithelial-cell-lipid-metabolism
#11
David W Kamp
No abstract text is available yet for this article.
April 26, 2018: American Journal of Respiratory Cell and Molecular Biology
https://www.readbyqxmd.com/read/29698615/idiopathic-pulmonary-fibrosis-cell-death-and-inflammation-revisited
#12
Claude Jourdan Le Saux, Harold A Chapman
No abstract text is available yet for this article.
April 26, 2018: American Journal of Respiratory Cell and Molecular Biology
https://www.readbyqxmd.com/read/29698614/the-expression-and-functional-analysis-of-cst1-in-intractable-nasal-polyps
#13
Yukinori Kato, Tetsuji Takabayashi, Masafumi Sakashita, Yoshimasa Imoto, Takahiro Tokunaga, Takahiro Ninomiya, Taiyo Morikawa, Kanako Yoshida, Emiko Noguchi, Shigeharu Fujieda
This study found Cystatin SN (CST1), a type 2 cystatin subfamily member, to be highly expressed in nasal polyps from patients with intractable chronic rhinosinusitis with nasal polyps (CRSwNP), using a whole transcript analysis with next-generation sequencing. Eosinophilic chronic rhinosinusitis (ECRS) involves nasal polyps that are refractory and recurrent immediately after endoscopic sinus surgery (ESS). We hypothesized that CST1 may contribute to the pathogenesis of ECRS. The expression of CST1 in nasal polyps from patients with ECRS was examined by mRNA expression levels, using real-time PCR and immunohistochemistry...
April 26, 2018: American Journal of Respiratory Cell and Molecular Biology
https://www.readbyqxmd.com/read/29694793/death-of-the-endothelium-in-sepsis-understanding-the-crime-scene
#14
Sunit Singla, Roberto F Machado
No abstract text is available yet for this article.
April 25, 2018: American Journal of Respiratory Cell and Molecular Biology
https://www.readbyqxmd.com/read/29694231/shedding-first-light-on-the-alveolar-epithelial-glycocalyx
#15
Sarah Weidenfeld, Wolfgang M Kuebler
No abstract text is available yet for this article.
April 25, 2018: American Journal of Respiratory Cell and Molecular Biology
https://www.readbyqxmd.com/read/29688757/a-step-closer-to-mechanism-and-additional-targeted-therapies-for-pulmonary-arterial-hypertension-links-between-red-blood-cell-lysis-and-vascular-dysfunction-in-pah
#16
Ciara M Shaver
No abstract text is available yet for this article.
April 24, 2018: American Journal of Respiratory Cell and Molecular Biology
https://www.readbyqxmd.com/read/29688752/more-than-a-tumor-suppressor-e-cadherin-loss-drives-lung-cancer-metastasis
#17
Jennifer R Devlin, Emmy W Verschuren
No abstract text is available yet for this article.
April 24, 2018: American Journal of Respiratory Cell and Molecular Biology
https://www.readbyqxmd.com/read/29676593/icos-costimulation-differentially-affects-t-cells-in-secondary-lymphoid-organs-and-inflamed-tissues
#18
Dana Vu Van, Laura Bauer, Richard A Kroczek, Andreas Hutloff
B cell interaction with follicular helper T cells and their subsequent differentiation into high-affinity antibody producing cells normally takes place in secondary lymphoid organs. The costimulator ICOS plays a key role in this process and is therefore considered as an attractive target to modulate exaggerated B cell responses in autoimmune or allergic diseases. Inflamed tissues were recently recognized as additional sites of active T cell/B cell interaction. To analyze whether ICOS costimulation is also important there, we employed a mouse airway inflammation model which allows to directly compare immune reactions in the lung-draining lymph node and the lung tissue and also to assess the relative importance of dendritic cells versus B cells as antigen-presenting cells...
April 20, 2018: American Journal of Respiratory Cell and Molecular Biology
https://www.readbyqxmd.com/read/29676587/a-potential-role-for-exosomal-tctp-export-in-vascular-remodeling-in-pulmonary-arterial-hypertension
#19
Elisabet Ferrer, Benjamin J Dunmore, Dhiya Hassan, Mark L Ormiston, Stephen Moore, John Deighton, Lu Long, Xu Dong Yang, Duncan J Stewart, Nicholas W Morrell
Pulmonary arterial hypertension (PAH) is characterized by increased proliferation and resistance to apoptosis of pulmonary vascular cells. Increased expression of translationally controlled tumor protein (TCTP), a pro-survival and anti-apoptotic mediator, has recently been demonstrated in patients with hereditary PAH (HPAH) although its role in the pathobiology of PAH remains unclear. Silencing of TCTP in blood outgrowth endothelial cells (BOECs) isolated from control subjects led to significant changes in morphology, cytoskeletal organization, increased apoptosis and decreased directionality during migration...
April 20, 2018: American Journal of Respiratory Cell and Molecular Biology
https://www.readbyqxmd.com/read/29676583/reticulocalbin-3-deficiency-in-alveolar-epithelium-exacerbated-bleomycin-induced-pulmonary-fibrosis
#20
Jiawei Jin, Xiaoqian Shi, Yongchao Li, Qianyu Zhang, Yu Guo, Chaokun Li, Pingping Tan, Qiuhong Fang, Yingmin Ma, Runlin Z Ma
Reticulocalbin 3 (Rcn3) is an endoplasmic reticulum (ER) lumen protein localized to the secretory pathway. We have reported that Rcn3 plays critical role for alveolar epithelial cell type II (AECII) maturation during perinatal lung development, but its biological role in the adult lung is largely unknown. Herein, we found marked induction of Rcn3 expression in alveolar epithelium during bleomycin-induced pulmonary fibrosis, which is most obvious in AECIIs. To further examine Rcn3 in pulmonary injury-remodeling, we generated transgenic mice to selectively delete Rcn3 in AECIIs in adulthood...
April 20, 2018: American Journal of Respiratory Cell and Molecular Biology
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