journal
MENU ▼
Read by QxMD icon Read
search

American Journal of Respiratory Cell and Molecular Biology

journal
https://www.readbyqxmd.com/read/30011381/chronic-cigarette-smoke-exposure-subdues-pp2a-activity-by-enhancing-expression-of-the-oncogene-cip2a
#1
Sridesh Nath, Michael Ohlmeyer, Matthias A Salathe, Justin Poon, Nathalie Baumlin, Robert F Foronjy, Patrick Geraghty
Phosphatase activity of the major serine threonine phosphatase, protein phosphatase 2A (PP2A), is blunted in the airways of chronic obstructive pulmonary disease (COPD) subjects, which results in heightened inflammation and proteolytic responses. The objective of this study was to investigate how PP2A activity is modulated in COPD airways. PP2A activity and endogenous inhibitors of PP2A were investigated in animal and cell models of COPD. In primary human bronchial epithelial (HBE) cells isolated from smokers and COPD donors, we observed enhanced expression of cancerous inhibitor of PP2A (CIP2A), an oncoprotein encoded by the KIAA1524 gene, compared to cells from nonsmokers...
July 16, 2018: American Journal of Respiratory Cell and Molecular Biology
https://www.readbyqxmd.com/read/30011373/ager-creer-t2-a-new-genetic-tool-for-studying-lung-alveolar-development-homeostasis-and-repair
#2
Mei-I Chung, Brigid L M Hogan
The alveolar region of the lung is composed of two major epithelial cell types; cuboidal Type 2 cells (AT2s), that produce surfactant proteins, and large, thin, Type1 cells (AT1s), specialized for efficient gas exchange. AT1s cover more than 95% of the alveolar surface and so constitute a major barrier to the entry of pathogenic agents. Relatively few genetic tools are available for studying the development of AT1s, the function of gene expressed in them, and the effect of specifically killing them in vivo in the adult lung...
July 16, 2018: American Journal of Respiratory Cell and Molecular Biology
https://www.readbyqxmd.com/read/29995434/sirtuin-1-a-new-potential-therapeutic-target-for-rhinosinusitis-who-nose
#3
Jonathan R Baker
No abstract text is available yet for this article.
July 11, 2018: American Journal of Respiratory Cell and Molecular Biology
https://www.readbyqxmd.com/read/29995431/supply-and-demand-micro-vascular-economics-of-the-right-ventricle-in-pulmonary-hypertension
#4
Todd M Kolb, Paul M Hassoun
No abstract text is available yet for this article.
July 11, 2018: American Journal of Respiratory Cell and Molecular Biology
https://www.readbyqxmd.com/read/29958015/inhaled-trim72-protein-protects-ventilation-injury-to-the-lung-through-injury-guided-cell-repair
#5
Nagaraja Nagre, Xiaofei Cong, Hong-Long Ji, John M Schreiber, Hongyun Fu, Ian Pepper, Seth Warren, Joshua M Sill, Rolf D Hubmayr, Xiaoli Zhao
[Rationale] Studies showed that TRIM72 is essential for repair of alveolar cell membrane disruptions, and exogenous TRIM72 protein (rhT72) demonstrated tissue-mending properties in animal models of tissue injury. [Objectives] To examine the mechanisms of rhT72-mediated lung cell protection in vitro and to test the efficacy of inhaled rhT72 in reducing tissue pathology in a mouse model of ventilator-induced lung injury (VILI). [Methods] In vitro lung cell injury was induced by glass beads and stretching. VILI was modeled by injurious ventilation at 30 ml/kg tidal volume...
June 29, 2018: American Journal of Respiratory Cell and Molecular Biology
https://www.readbyqxmd.com/read/29958012/carma3-mediates-allergic-lung-inflammation-in-response-to-alternaria-alternata
#6
Benjamin Causton, Ana Pardo-Saganta, Jacob Gillis, Katherine Discipio, Tristan Kooistra, Jayaraj Rajagopal, Ramnik J Xavier, Josalyn L Cho, Benjamin D Medoff
The response to allergens by airway epithelial cells help initiate and propagate allergic inflammation in asthma. Caspase recruitment domain-containing membrane-associated guanylate kinase protein 3 (CARMA3), is a scaffold protein that mediates G protein-coupled receptor induced NF-κB activation in airway epithelium. In this study, we demonstrate that mice with CARMA3-deficient airway epithelial cells have reduced airway inflammation, as well as reduced type 2 cytokine production in response to Alternaria alternata...
June 29, 2018: American Journal of Respiratory Cell and Molecular Biology
https://www.readbyqxmd.com/read/29953261/immune-surveillance-by-natural-igm-is-required-for-early-neoantigen-recognition-and-initiation-of-adaptive-immunity
#7
Shaikh M Atif, Sophie L Gibbings, Elizabeth F Redente, Faye A Camp, Raul M Torres, Ross M Kedl, Peter M Henson, Claudia V Jakubzick
Early recognition of neoantigen-expressing cells is complex, involving multiple immune cell types. In this study, in vivo, we examined how antigen-presenting cell (APC) subtypes coordinate and induce an immunological response against neoantigen-expressing cells, particularly in the absence of a pathogen-associated molecular pattern (PAMP), which is normally required to license APCs to present foreign or self-antigens as immunogens. Using two reductionist models of neoantigen-expressing cells and two cancer models, we demonstrated that natural IgM is essential for the recognition and initiation of adaptive immunity against neoantigen-expressing cells...
June 28, 2018: American Journal of Respiratory Cell and Molecular Biology
https://www.readbyqxmd.com/read/29953256/structurally-unsound-why-airways-become-asthmatic
#8
Andrew Bush, Sejal Saglani
No abstract text is available yet for this article.
June 28, 2018: American Journal of Respiratory Cell and Molecular Biology
https://www.readbyqxmd.com/read/29949718/whole-genome-sequencing-in-severe-chronic-obstructive-pulmonary-disease
#9
Dmitry Prokopenko, Phuwanat Sakornsakolpat, Heide Loehlein Fier, Dandi Qiao, Margaret M Parker, Merry-Lynn N McDonald, Ani Manichaikul, Stephen S Rich, R Graham Barr, Christopher J Williams, Mark L Brantly, Christoph Lange, Terri H Beaty, James D Crapo, Edwin K Silverman, Michael H Cho
RATIONALE: Genome-wide association studies (GWAS) have identified common variants associated with chronic obstructive pulmonary disease (COPD). Whole-genome sequencing (WGS) offers comprehensive coverage of the entire genome compared with genotyping arrays or exome sequencing. OBJECTIVES: We hypothesized that WGS in subjects with severe COPD and smoking controls with normal pulmonary function would allow us to identify novel genetic determinants of COPD. METHODS: We sequenced 821 severe COPD cases and 973 controls from the COPDGene and Boston Early-Onset COPD studies, including both non-Hispanic white (NHW) and African Americans (AA)...
June 27, 2018: American Journal of Respiratory Cell and Molecular Biology
https://www.readbyqxmd.com/read/29944393/dna-methylation-regulates-rgs2-induced-s100a12-expression-in-airway-epithelial-cells
#10
Guillaume F Bouvet, Gregory Voisin, Yannick Cyr, Virginie Bascunana, Chantal Massé, Yves Berthiaume
BACKGROUND: RGS2 is a key modulator of stress in human airway epithelial cells, especially of hyperresponsiveness and mucin hypersecretion, both features of cystic fibrosis (CF). Because its expression can be modulated through the DNA methylation pathway, we hypothesize that RGS2 is downregulated by DNA hypermethylation in CF airway epithelial cells. This downregulation would then lead to an enhanced inflammatory response. RESULTS: We demonstrated RGS2 transcript and protein downregulation in cultured airway epithelial cells from CF patients and validated our findings in 2 CF epithelial cell lines...
June 26, 2018: American Journal of Respiratory Cell and Molecular Biology
https://www.readbyqxmd.com/read/29944387/cigarette-smoking-impairs-the-bioenergetic-immune-response-to-mycobacterium-tuberculosis-infection
#11
Laura E Gleeson, Daniel Ryan, Seonadh M O'Leary, Anne Marie McLaughlin, Frederick J Sheedy, Joseph M Keane
RATIONALE: Smoking is a major risk factor driving the tuberculosis (TB) epidemic and smokers' alveolar macrophages (AM) demonstrate significant immune defects following infection. Recently, macrophage glycolytic reprogramming has emerged as crucial in the early host immune response to Mycobacterium tuberculosis (Mtb) infection. OBJECTIVES: To compare baseline metabolic characteristics and the glycolytic response to infection of human AM from smokers and non-smokers...
June 26, 2018: American Journal of Respiratory Cell and Molecular Biology
https://www.readbyqxmd.com/read/29924940/tctp-in-extracellular-vehicles-dangerous-cargo
#12
Katharina Jandl, Christopher D Gregory, Grazyna Kwapiszewska
No abstract text is available yet for this article.
June 20, 2018: American Journal of Respiratory Cell and Molecular Biology
https://www.readbyqxmd.com/read/29924938/discoidin-domain-receptor-2-a-potential-therapeutic-target-in-lung-fibrosis
#13
Corina M Borza, Ambra Pozzi, Erin J Plosa
No abstract text is available yet for this article.
June 20, 2018: American Journal of Respiratory Cell and Molecular Biology
https://www.readbyqxmd.com/read/29894205/elafin-treatment-rescues-egfr-klf4-signaling-and-lung-cell-survival-in-ventilated-newborn-mice
#14
Miguel A Alejandre Alcazar, Mark Kaschwich, Robert Ertsey, Stefanie Preuss, Carlos Milla, Sana Mujahid, Juliet Masumi, Suleman Khan, Lucia M Mokres, Lu Tian, Jasmine Mohr, Dharmesh V Hirani, Marlene Rabinovitch, Richard D Bland
RATIONALE: Mechanical ventilation with O2 -rich gas (MV-O2 ) inhibits alveologenesis and lung growth. We showed that MV-O2 increases elastase activity and apoptosis in lungs of newborn mice; elastase inhibition by elafin suppressed apoptosis and enabled lung growth. In pilot studies, MV-O2 reduced lung expression of pro-survival factors, pEGFR and Klf4. OBJECTIVES: Determine if apoptosis and lung growth arrest evoked by MV-O2 reflect disrupted pEGFR-Klf4 signaling, which elafin treatment preserves...
June 12, 2018: American Journal of Respiratory Cell and Molecular Biology
https://www.readbyqxmd.com/read/29894204/lung-defense-through-interleukin-8-carries-a-cost-of-chronic-lung-remodeling-and-impaired-function
#15
Catherine J Reynolds, Kathryn Quigley, Xiaoming Cheng, Apurva Suresh, Sundas Tahir, Fiyyaz Ahmed-Jushuf, Khizr Nawab, Katherine Choy, Simone Alexandra Walker, Sara A Mathie, Malcolm Sim, Janet Stowell, Jiten Manji, Tracey Pollard, Daniel M Altmann, Rosemary J Boyton
RATIONALE: IL-8 dependent inflammation is a hallmark of host lung innate immunity to bacterial pathogens, yet in many human lung diseases including COPD, bronchiectasis, and pulmonary fibrosis, there are progressive, irreversible pathologic, changes associated with elevated levels of IL-8 in the lung. OBJECTIVES: To better understand the duality of IL-8 dependent host immunity to bacterial infection and lung pathology, we targeted human IL-8 to express transgenically in murine bronchial epithelium, investigating the impact of over-expression on lung bacterial clearance, host immunity, lung pathology and function...
June 12, 2018: American Journal of Respiratory Cell and Molecular Biology
https://www.readbyqxmd.com/read/29864376/harmful-interruptions-impact-of-smoking-patterns-on-tumorigenesis-and-emphysema
#16
Kent E Pinkerton, Morgan E Poindexter
No abstract text is available yet for this article.
June 4, 2018: American Journal of Respiratory Cell and Molecular Biology
https://www.readbyqxmd.com/read/29863910/maternal-cytokine-profiles-during-pregnancy-predict-asthma-in-children-of-nonasthmatic-mothers
#17
Janet Rothers, Debra A Stern, I Carla Lohman, Amber Spangenberg, Anne L Wright, Avery DeVries, Donata Vercelli, Marilyn Halonen
Little is known about whether maternal immune status during pregnancy influences asthma development in the child. We measured cytokine production in supernatants from mitogen-stimulated peripheral blood immune cells collected during and after pregnancy from the mothers of children enrolled in the Tucson Infant Immune Study, a non-selected birth cohort. Physician-diagnosed active asthma in children through age 9 and a history of asthma in their mothers were assessed through questionnaires. Maternal production of each of the cytokines IL-13, IL-4, IL-5, IFN-γ, IL-10, and IL-17 during pregnancy was unrelated to childhood asthma...
June 4, 2018: American Journal of Respiratory Cell and Molecular Biology
https://www.readbyqxmd.com/read/29852080/all-trans-retinoic-acid-augments-autophagy-during-intracellular-bacterial-infection
#18
Michelle M Coleman, Sharee A Basdeo, Amy M Coleman, Clíona Ní Cheallaigh, Celia Peral de Castro, Anne Marie McLaughlin, Padraic J Dunne, James Harris, Joseph Keane
Vitamin A deficiency strongly predicts the risk of developing tuberculosis (TB) in individuals exposed to Mycobacterium tuberculosis (Mtb). The burden of antibiotic resistant TB is increasing globally therefore there is an urgent need to develop host-directed adjunctive therapies to treat TB. Alveolar macrophages (AM), the niche cell for Mtb, metabolize vitamin A to all-trans retinoic acid (atRA), which influences host immune responses. We sought to determine the mechanistic effects of atRA on the host immune response to intracellular bacterial infection in primary human and murine macrophages...
May 31, 2018: American Journal of Respiratory Cell and Molecular Biology
https://www.readbyqxmd.com/read/29851510/quantifying-ciliary-dynamics-during-assembly-reveals-step-wise-waveform-maturation-in-airway-cells
#19
Alina Oltean, Andrew J Schaffer, Philip V Bayly, Steven L Brody
Motile cilia are essential for clearance of particulates and pathogens from airways. For effective transport, ciliary motor proteins and axonemal structures interact to generate the rhythmic, propulsive bending, but the mechanisms that produce a dynamic waveform remain incompletely understood. Biomechanical measures of human cilia motion and their relationships to cilia assembly are needed to illuminate the biophysics of normal cilia function, and to quantify dysfunction in ciliopathies. To these ends, we analyzed cilia motion from high-speed video microscopy of ciliated cells sampled from human lung airways compared to primary-culture cells that undergo ciliogenesis in vitro...
May 31, 2018: American Journal of Respiratory Cell and Molecular Biology
https://www.readbyqxmd.com/read/29851508/vascular-adaptation-of-the-right-ventricle-in-experimental-pulmonary-hypertension
#20
Brian B Graham, Rahul Kumar, Claudia Mickael, Biruk Kassa, Dan Koyanagi, Linda Sanders, Li Zhang, Mario Perez, Daniel Hernandez-Saavedra, Carolyn Valencia, Kandice Dixon, Julie Harral, Zoe Loomis, David Irwin, Travis Nemkov, Angelo D'Alessandro, Kurt R Stenmark, Rubin M Tuder
RATIONALE: Optimal right ventricle (RV) function in pulmonary hypertension (PH) requires structural and functional coupling between the RV cardiomyocyte and its adjacent capillary network. Prior investigations have indicated RV vascular rarefaction occurs in PH, which could contribute to RV failure by reduced delivery of oxygen or other metabolic substrates. However, it has not been determined if rarefaction results from relative underproliferation in the setting of tissue hypertrophy, or actual loss of vessels...
May 31, 2018: American Journal of Respiratory Cell and Molecular Biology
journal
journal
30297
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"