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American Journal of Respiratory Cell and Molecular Biology

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https://www.readbyqxmd.com/read/30240285/sex-differences-in-pulmonary-responses-to-ozone-in-mice-role-of-the-microbiome
#1
Youngji Cho, Galeb Abu-Ali, Hiroki Tashiro, Traci A Brown, Ross Osgood, David I Kasahara, Curtis Huttenhower, Stephanie A Shore
We have previously reported that the mouse gut microbiome contributes to pulmonary responses to ozone, a common asthma trigger, and that short chain fatty acids, end products of bacterial fermentation, likely contribute to this role of the microbiome. A growing body of evidence indicates sex-related differences in gut microbiota and that these differences can have important functional consequences. The purpose of this study was to determine whether there were sex-related differences in the impact of the gut microbiota on pulmonary responses to ozone...
September 21, 2018: American Journal of Respiratory Cell and Molecular Biology
https://www.readbyqxmd.com/read/30240278/interleukin-9-blockade-suppresses-silica-induced-lung-inflammation-and-fibrosis-in-mice
#2
Naoya Sugimoto, Maho Suzukawa, Hiroyuki Nagase, Yuta Koizumi, Shoki Ro, Konomi Kobayashi, Hisanao Yoshihara, Yasuhiro Kojima, Asae Kamiyama-Hara, Akira Hebisawa, Ken Ohta
Recapitulative animal models of idiopathic pulmonary fibrosis (IPF) and related diseases are lacking, which inhibits our ability to fully clarify the pathogenesis of these diseases. Although lung fibrosis in mouse models is often induced by bleomycin, silica-induced lung fibrosis is more sustainable and more progressive. Therefore, in this study, we sought to elucidate the mediator(s) responsible for the pathogenesis of lung fibrosis through the use of a mouse model of silica-induced lung fibrosis. With a single nasal administration of 16 mg of silica, lung inflammation (assessed by elevated cellular components in the bronchoalveolar lavage fluids [BALFs]) and lung fibrosis (assessed by lung histology and lung hydroxyproline levels) were induced and sustained for as long as 24 weeks...
September 21, 2018: American Journal of Respiratory Cell and Molecular Biology
https://www.readbyqxmd.com/read/30230353/intercellular-communication-between-airway-epithelial-cells-is-mediated-by-exosome-like-vesicles
#3
Richa Gupta, Giorgia Radicioni, Sabri Abdelwahab, Hong Dang, Jerome Carpenter, Michael Chua, Piotr A Mieczkowski, John Sheridan, Scott H Randell, Mehmet Kesimer
Airway epithelium structure/function can be altered by local inflammatory/immune signals, and this process is called epithelial remodeling. The mechanism by which this innate response is regulated, which causes mucin/mucus overproduction, is largely unknown. Exosomes are nano-vesicles that can be secreted and internalized by cells to transport cellular cargo, such as proteins, lipids, and miRNA. The objective of this study was to understand the role exosomes play in airway remodeling through cell-cell communication...
September 19, 2018: American Journal of Respiratory Cell and Molecular Biology
https://www.readbyqxmd.com/read/30230352/induced-pluripotent-stem-cells-for-primary-ciliary-dyskinesia-modeling-and-personalized-medicine
#4
Joffrey Mianné, Engi Ahmed, Chloé Bourguignon, Mathieu Fieldes, Isabelle Vachier, Arnaud Bourdin, Said Assou, John De Vos
Primary ciliary dyskinesia (PCD) is a rare and heterogeneous genetic disorder that affects the structure and function of motile cilia. In the airway epithelium, impaired ciliary motion results in reduced or absent mucociliary clearance that leads to the appearance of chronic airway infection, sinusitis and bronchiectasis. Currently, there is no effective treatment for PCD, and research is limited by the lack of convenient models to study this disease and investigate innovative therapies. Furthermore, the high heterogeneity of PCD genotypes is likely to hinder the development of a single therapy for all patients...
September 19, 2018: American Journal of Respiratory Cell and Molecular Biology
https://www.readbyqxmd.com/read/30230348/p311-promotes-lung-fibrosis-via-stimulation-of-tgf-%C3%AE-1-2-and-3-translation
#5
Fang-Fang Duan, Gabriel Barron, Angelo Meliton, Gokhan M Mutlu, Nickolai O Dulin, Lucia Schuger
Interstitial lung fibrosis, a frequently idiopathic and fatal disease, has been linked to the increased expression of profibrotic TGF-βs. P311 is an RNA-binding protein, which stimulates TGF-β1, 2 and 3 translation in several cell types through its interaction with the eukaryotic translation initiation factor 3b. Here we report that P311 is switched on in the lungs of Idiopathic pulmonary fibrosis (IPF) patients and in the mouse model of bleomycin (BLM)-induced pulmonary fibrosis. To assess the in vivo role of P311 in lung fibrosis, BLM was instilled into the lungs of P311 knockout (KO) mice where fibrotic changes were significantly decreased in tandem with a reduction in TGF-β1, 2 and 3 levels/activity compared to BLM-treated wild type (WT) mice...
September 19, 2018: American Journal of Respiratory Cell and Molecular Biology
https://www.readbyqxmd.com/read/30230347/a-non-hospitable-host-targeting-cellular-factors-as-an-antiviral-strategy-for-respiratory-viruses
#6
Luciano Amarelle, Emilia Lecuona
No abstract text is available yet for this article.
September 19, 2018: American Journal of Respiratory Cell and Molecular Biology
https://www.readbyqxmd.com/read/30230345/recommended-reading-from-the-national-university-of-ireland-galway-regenerative-medicine-institute-remedi-lung-biology-group-fellows
#7
Emanuele Rezoagli, Claire H Masterson, Sean D McCarthy, John G Laffey
No abstract text is available yet for this article.
September 19, 2018: American Journal of Respiratory Cell and Molecular Biology
https://www.readbyqxmd.com/read/30211627/survivin-ipf-targeting-cellular-metabolism-to-promote-apoptosis-in-ipf-fibroblasts
#8
Dakota L Jones, Giovanni Ligresti
No abstract text is available yet for this article.
September 13, 2018: American Journal of Respiratory Cell and Molecular Biology
https://www.readbyqxmd.com/read/30211613/quercetin-in-idiopathic-pulmonary-fibrosis-another-brick-in-senolytic-wall
#9
Jacobo Sellarés, Mauricio Rojas
No abstract text is available yet for this article.
September 13, 2018: American Journal of Respiratory Cell and Molecular Biology
https://www.readbyqxmd.com/read/30199644/relation-between-respiratory-mechanics-inflammation-and-survival-in-experimental-mechanical-ventilation
#10
Margit V Szabari, Kazue Takahashi, Yan Feng, Joseph J Locascio, Wei Chao, Edward A Carter, Marcos F Vidal Melo, Guido Musch
RATIONALE: Low tidal volume ventilation might protect healthy lungs from volutrauma but lead to inflammation from other mechanisms, namely alveolar derecruitment and the ensuing alveolar collapse and reexpansion. OBJECTIVE: We hypothesized that the different mechanisms of low and high volume injury would be reflected in different mechanical properties being associated with development of pulmonary inflammation and mortality: an increase of hysteresis, reflecting progressive alveolar derecruitment, at low tidal volume; an increase of elastance, as a result of overdistension, at higher tidal volume...
September 10, 2018: American Journal of Respiratory Cell and Molecular Biology
https://www.readbyqxmd.com/read/30183330/impairment-of-fatty-acid-oxidation-in-alveolar-epithelial-cells-mediates-acute-lung-injury
#11
Huachun Cui, Na Xie, Sami Banerjee, Jing Ge, Sijia Guo, Gang Liu
Profound impairment in cellular oxygen consumption, named cytopathic dysoxia, is one of the pathological hallmarks in the lungs of patients with pathogen-induced acute lung injury (ALI). However, the underlying mechanism for this functional defect remains largely unexplored. In this study, we found that primary mouse alveolar epithelial cells (AECs) conducted robust fatty acid oxidation (FAO). More importantly, FAO was strikingly impaired in AECs of mice with lipopolysaccharide (LPS) induced ALI. The metabolic deficiency in these cells was likely due to decreased expression of key mediators involved in FAO and mitochondrial bioenergenesis, such as PGC-1α, CPT1A and MCAD...
September 5, 2018: American Journal of Respiratory Cell and Molecular Biology
https://www.readbyqxmd.com/read/30183325/the-effects-of-ifn-%C3%AE-on-epithelial-barrier-function-contribute-to-k-pneumoniae-st258-pneumonia
#12
Danielle Ahn, Matthew Wickersham, Sebastian Riquelme, Alice Prince
IFN-λ and IL-22, cytokines that share the co-receptor IL-10RB, are both induced over the course of Klebsiella pneumoniae ST258 (KP35) pneumonia. IL-22 is known to protect mucosal barriers whereas the effects of IFN-λ on the mucosa are not established. We postulated that IFN-λ plays a role in regulating the airway epithelial barrier to facilitate cellular trafficking to the site of infection. In response to IFN-λ the transmigration of neutrophils across a polarized monolayer of airway epithelial cells was increased, consistent with diminished epithelial integrity...
September 5, 2018: American Journal of Respiratory Cell and Molecular Biology
https://www.readbyqxmd.com/read/30183323/lung-microbiome-is-influenced-by-the-environment-and-asthmatic-status-in-an-equine-model-of-asthma
#13
Gabrielle Fillion-Bertrand, Robert P Dickson, Roxane Boivin, Jean-Pierre Lavoie, Gary B Huffnagle, Mathilde Leclere
RATIONALE: There is evidence that lung microbiome differs between asthmatic and healthy humans, but the effect of environmental conditions and medication is unknown and difficult to study. Equine asthma is a naturally occurring chronic airway disease characterized by reversible airway inflammation and bronchoconstriction upon exposure to inhaled antigens. OBJECTIVES: To evaluate the effect that environmental conditions and disease status have on pulmonary, nasal and oral microbiome...
September 5, 2018: American Journal of Respiratory Cell and Molecular Biology
https://www.readbyqxmd.com/read/30157386/betting-on-novel-treatments-for-asthma-bromodomain-4-inhibitors
#14
Yan Y Sanders, Victor J Thannickal
No abstract text is available yet for this article.
August 29, 2018: American Journal of Respiratory Cell and Molecular Biology
https://www.readbyqxmd.com/read/30157385/could-immunotherapy-sink-its-teeth-into-lam
#15
Adam Pietrobon, Sean P Delaney, William L Stanford
No abstract text is available yet for this article.
August 29, 2018: American Journal of Respiratory Cell and Molecular Biology
https://www.readbyqxmd.com/read/30156437/intracellular-c3-protects-human-airway-epithelial-cells-from-stress-associated-cell-death
#16
Hrishikesh S Kulkarni, Michelle L Elvington, Yi-Chieh Perng, M Kathryn Liszewski, Derek E Byers, Christopher Farkouh, Roger D Yusen, Deborah J Lenschow, Steven L Brody, John P Atkinson
The complement system provides host defense against pathogens and environmental stress. C3, the central component of complement, is present in the blood and increases in the bronchoalveolar lavage fluid following injury. We recently discovered that C3 is taken up by certain cell types and cleaved intracellularly to C3a and C3b. C3a is required for CD4+T cell survival. These observations made us question if complement operates at environmental interfaces, particularly in the respiratory tract. We found that airway epithelial cells [AECs, represented by both primary human tracheobronchial cells (hTECs) and BEAS-2B (cell line)] cultured in C3-free media were unique from other cell types in that they contained large intracellular stores of de novo synthesized C3...
August 29, 2018: American Journal of Respiratory Cell and Molecular Biology
https://www.readbyqxmd.com/read/30156431/identification-of-a-novel-inhibitor-of-hrv-replication-and-inflammation-in-airway-epithelial-cells
#17
Zhonghui Yang, Yury A Bochkov, Dennis R Voelker, Matthew W Foster, Loretta G Que
Human rhinovirus (RV), the major cause of the common cold, triggers the majority of acute airway exacerbations in patients with asthma and chronic obstructive pulmonary disease. Nitric oxide (NO), and the related metabolite S-nitrosoglutathione (GSNO), are produced in the airway epithelium via nitric oxide synthase 2 (NOS2) and have been shown to function in host defense against RV infection. We hypothesized that inhibitors of the GSNO-metabolizing enzyme, GSNO reductase (GSNOR), might potentiate the antiviral properties of airway-derived NOS2...
August 29, 2018: American Journal of Respiratory Cell and Molecular Biology
https://www.readbyqxmd.com/read/30156429/endothelial-yap1-in-regenerative-lung-growth-through-the-angiopoietin-tie2-pathway
#18
Tadanori Mammoto, Megan Muyleart, Akiko Mammoto
Angiogenesis, the formation of new blood capillaries, plays a key role in organ development and regeneration. Inhibition of lung angiogenesis through the blockade of angiogenic signaling pathways impairs compensatory and regenerative lung growth after unilateral pneumonectomy (PNX). The Hippo signaling transducer, Yes-associated protein (YAP1) binds to TEA domain transcription factor (TEAD) and controls organ size and regeneration. However, the role of endothelial YAP1 in lung vascular and alveolar morphogenesis remains unclear...
August 29, 2018: American Journal of Respiratory Cell and Molecular Biology
https://www.readbyqxmd.com/read/30153047/efficacy-of-novel-highly-specific-bromodomain-containing-protein-4-inhibitors-in-innate-inflammation-driven-airway-remodeling
#19
Bing Tian, Zhiqing Liu, Julia Litvinov, Rosario Maroto, Mohammad Jamaluddin, Erik Rytting, Igor Patrikeev, Lorenzo Ochoa, Gracie Vargas, Massoud Motamedi, Bill T Ameredes, Jia Zhou, Allan R Brasier
NFκB/RelA triggers innate inflammation by binding to Bromodomain-Containing Protein 4 (BRD4), an atypical histone acetyltransferase (HAT). Although RelA·BRD4 HAT mediates acute neutrophilic inflammation, its role in chronic and functional airway remodeling is not known. We observed that BRD4 is required for TLR3 mediated mesenchymal transition, a cell-state change that is characteristic of remodeling. We therefore tested novel highly selective BRD4 inhibitors, ZL0420 and -0454, on chronic airway remodeling produced by repetitive TLR3 agonist challenges, and compared their efficacy with nonselective BET protein inhibitors, JQ1 and RVX208...
August 28, 2018: American Journal of Respiratory Cell and Molecular Biology
https://www.readbyqxmd.com/read/30141971/dna-methylation-changes-in-lung-immune-cells-are-associated-with-granulomatous-lung-disease
#20
Ivana V Yang, Iain Konigsberg, Kristyn MacPhail, Li Li, Elizabeth J Davidson, Peggy M Mroz, Nabeel Hamzeh, May Gillespie, Lori J Silveira, Tasha E Fingerlin, Lisa A Maier
RATIONALE: Epigenetic marks are likely to explain variability of response to antigen in granulomatous lung disease. OBJECTIVES: To identify DNA methylation and gene expression changes associated with chronic beryllium disease (CBD) and sarcoidosis in lung cells obtained by bronchoalveolar lavage (BAL). METHODS: BAL cells from CBD (n=8), BeS (n=8), sarcoidosis (n=8), and additional progressive (n=9) and remitting (n=15) cases of sarcoidosis were profiled on the Illumina 450K methylation and Affymetrix/Agilent gene expression microarrays...
August 24, 2018: American Journal of Respiratory Cell and Molecular Biology
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