journal
MENU ▼
Read by QxMD icon Read
search

International Immunology

journal
https://www.readbyqxmd.com/read/27836913/immunoreceptor-cd300a-on-mast-cells-and-dendritic-cells-regulates-neutrophil-recruitment-in-a-murine-model-of-sepsis
#1
Kankanam Gamage Sanath Udayanga, Yoshiyuki Nakamura, Chigusa Nakahashi-Oda, Akira Shibuya
Sepsis is a life-threatening syndrome caused by abnormal host immune responses against bacterial infection. Although innate immune cells are known to be important in the pathogenesis of sepsis, how their activation is regulated during sepsis remains incompletely understood. Here, we examined the role of the inhibitory immunoreceptor CD300a, which is expressed on various types of myeloid cells, in the pathogenesis of sepsis induced by cecal ligation and puncture (CLP). To this end, we used mice in which CD300a was specifically deleted on mast cells (MCs; Cd300a (fl/fl) Mcpt5-Cre), dendritic cells (DCs; Cd300a (fl/fl) Itgax-Cre), or macrophages and neutrophils (Cd300a (fl/fl) Lyz2-Cre)...
November 11, 2016: International Immunology
https://www.readbyqxmd.com/read/27932517/allergin-1-inhibits-tlr2-mediated-mast-cell-activation-and-suppresses-dermatitis
#2
Satoshi Tsurusaki, Satoko Tahara-Hanaoka, Shohei Shibagaki, Shota Miyake, Masamichi Imai, Shiro Shibayama, Masato Kubo, Akira Shibuya
TLR2 recognizes cell wall components of Staphylococcus aureus, which colonizes >90% of atopic eczematous skin lesions. The regulatory mechanisms of TLR2 signaling in the skin remain unclear. Allergin-1, an inhibitory immunoglobulin-like receptor containing an ITIM, is expressed on mast cells (MCs) and inhibits IgE-mediated anaphylaxis in mice. Here, we show that Allergin-1 inhibits TLR2-mediated activation of, and inflammatory cytokine production by, MCs in vitro Compared with wild-type mice, Allergin-1-deficient mice showed enhanced ear swelling with enhanced collagen deposition and greater Ly6G(+) neutrophil recruitment after intra-dermal injection of Pam2CSK4 into pinnae...
November 8, 2016: International Immunology
https://www.readbyqxmd.com/read/27803063/the-role-of-%C3%AE-4-integrin-in-theiler-s-murine-encephalomyelitis-virus-tmev-induced-demyelinating-disease-an-infectious-animal-model-for-multiple-sclerosis-ms
#3
Yuta Hirano, Kunitoshi Kobayashi, Hiroki Tomiki, Yuhji Inaba, Motoki Ichikawa, Byung S Kim, Chang-Sung Koh
Natalizumab, which is an antibody against α4 integrin, has been used for the treatment of multiple sclerosis (MS). In the present study, we investigated both the role of α4 integrin and the therapeutic effect of HCA3551, a newly synthesized orally active small-molecule α4 integrin antagonist, in the development of TMEV-induced demyelinating disease (TMEV-IDD). The mRNA levels of α4 integrins were significantly up-regulated in the CNS of mice with TMEV-IDD as compared with naïve mice (*p<0.05). HCA3551 treatment in the effector phase significantly suppressed both the clinical and histological development of TMEV-IDD...
November 1, 2016: International Immunology
https://www.readbyqxmd.com/read/27742834/tolerogenic-immunoreceptor-ilt3-lilrb4-paradoxically-marks-pathogenic-auto-antibody-producing-plasmablasts-and-plasma-cells-in-non-treated-sle
#4
Masanori Inui, Akiko Sugahara-Tobinai, Hiroshi Fujii, Ari Itoh-Nakadai, Hidehiro Fukuyama, Tomohiro Kurosaki, Tomonori Ishii, Hideo Harigae, Toshiyuki Takai
Plasmablasts and plasma cells (PBs and PCs) producing pathogenic auto-antibodies in patients with systemic autoimmune diseases could be a better target for specific therapies for the disease than general immunosuppression or pan- or activated B-cell targeting. Our previous study indicated that leukocyte immunoglobulin-like receptor (LILR) B4 (B4, also known as ILT3/LIR-5/CD85k), a tolerogenic receptor in antigen-presenting cells, is ectopically expressed on the PB/PC surface in healthy individuals. Here, we show that the enlarged population size of PBs/PCs with augmented B4 expression is characteristic in non-treated systemic lupus erythematosus (SLE)...
October 14, 2016: International Immunology
https://www.readbyqxmd.com/read/27794012/table-of-contents
#5
(no author information available yet)
No abstract text is available yet for this article.
November 2016: International Immunology
https://www.readbyqxmd.com/read/27794011/subscriptions
#6
(no author information available yet)
No abstract text is available yet for this article.
November 2016: International Immunology
https://www.readbyqxmd.com/read/27794010/cover
#7
(no author information available yet)
No abstract text is available yet for this article.
November 2016: International Immunology
https://www.readbyqxmd.com/read/27794009/important-announcement
#8
EDITORIAL
Shizuo Akira
No abstract text is available yet for this article.
November 2016: International Immunology
https://www.readbyqxmd.com/read/27794008/in-this-issue
#9
(no author information available yet)
No abstract text is available yet for this article.
November 2016: International Immunology
https://www.readbyqxmd.com/read/27543653/cell-cycle-arrest-caused-by-mek-erk-signaling-is-a-mechanism-for-suppressing-growth-of-antigen-hyperstimulated-effector-t-cells
#10
Shizuka Ohtsuka, Shuhei Ogawa, Ei Wakamatsu, Ryo Abe
Suppression of T-cell growth is an important mechanism for establishment of self-tolerance and prevention of unwanted prolonged immune responses that may cause tissue damage. Although negative selection of potentially self-reactive T cells in the thymus as well as in peripheral tissues has been extensively investigated and well documented, regulatory mechanisms to dampen proliferation of antigen-specific effector T cells in response to antigen stimulation remain largely unknown. Thus, in this work, we focus on the identification of growth suppression mechanisms of antigen-specific effector T cells...
November 2016: International Immunology
https://www.readbyqxmd.com/read/27432280/antibody-secreting-cells-in-respiratory-tract-tissues-in-the-absence-of-eosinophils-as-supportive-partners
#11
Robert E Sealy, Sherri L Surman, Peter Vogel, Julia L Hurwitz
Antibody-secreting cells (ASCs) in respiratory tract tissues provide a first line of defense against invading pathogens. These cells often secrete IgA that is efficiently transcytosed across epithelial barriers into the airway lumen where pathogens can be blocked at their point of entry. Previous literature has reported that in the bone marrow, eosinophils are required for the maintenance of ASCs, and that eosinophils co-localize with ASCs as nearest neighbors. To determine if these rules similarly apply to the maintenance of ASCs in respiratory tract tissues, we evaluated virus-specific responses 1 month and 4 months following an intranasal virus infection of eosinophil-null (∆dblGATA-1) mice...
November 2016: International Immunology
https://www.readbyqxmd.com/read/27694205/table-of-contents
#12
(no author information available yet)
No abstract text is available yet for this article.
October 2016: International Immunology
https://www.readbyqxmd.com/read/27694204/subscriptions
#13
(no author information available yet)
No abstract text is available yet for this article.
October 2016: International Immunology
https://www.readbyqxmd.com/read/27694203/cover
#14
(no author information available yet)
No abstract text is available yet for this article.
October 2016: International Immunology
https://www.readbyqxmd.com/read/27694202/in-this-issue
#15
(no author information available yet)
No abstract text is available yet for this article.
October 2016: International Immunology
https://www.readbyqxmd.com/read/27581669/table-of-contents
#16
(no author information available yet)
No abstract text is available yet for this article.
September 2016: International Immunology
https://www.readbyqxmd.com/read/27581668/subscriptions
#17
(no author information available yet)
No abstract text is available yet for this article.
September 2016: International Immunology
https://www.readbyqxmd.com/read/27581667/cover
#18
(no author information available yet)
No abstract text is available yet for this article.
September 2016: International Immunology
https://www.readbyqxmd.com/read/27581666/in-this-issue
#19
(no author information available yet)
No abstract text is available yet for this article.
September 2016: International Immunology
https://www.readbyqxmd.com/read/27055469/cpg-mediated-augmentation-of-cd8-t-cell-responses-in-mice-is-attenuated-by-a-water-in-oil-emulsion-montanide-isa-51-but-enhanced-by-an-oil-in-water-emulsion-idri-se
#20
Shawn R Makinen, Qin Zhu, Heather L Davis, Risini D Weeratna
Adjuvants are a key component in enhancing immunogenicity of vaccines and play a vital role in facilitating the induction of the correct type of immunity required for each vaccine to be optimally efficacious. Several different adjuvants are found in licensed vaccines, and many others are in pre-clinical or clinical testing. Agonists for TLRs are potent activators of the innate immune system and some, such as CpG (TLR9 agonist), are particularly good for promoting cellular immunity because of the induction of Th1 cytokines...
September 2016: International Immunology
journal
journal
30278
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"