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Behavioural Neurology

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https://www.readbyqxmd.com/read/28133419/mice-with-catalytically-inactive-cathepsin-a-display-neurobehavioral-alterations
#1
O Y Calhan, V Seyrantepe
The lysosomal carboxypeptidase A, Cathepsin A (CathA), is a serine protease with two distinct functions. CathA protects β-galactosidase and sialidase Neu1 against proteolytic degradation by forming a multienzyme complex and activates sialidase Neu1. CathA deficiency causes the lysosomal storage disease, galactosialidosis. These patients present with a broad range of clinical phenotypes, including growth retardation, and neurological deterioration along with the accumulation of the vasoactive peptide, endothelin-1, in the brain...
2017: Behavioural Neurology
https://www.readbyqxmd.com/read/28082766/vestibular-migraine-clinical-challenges-and-opportunities-for-multidisciplinarity
#2
REVIEW
Isabel Luzeiro, Leonel Luís, Freire Gonçalves, Isabel Pavão Martins
Migraine and vertigo are two very prevalent conditions in general population. The coexistence of both in the same subject is a significant clinical challenge, since it is not always possible to understand whether they are causally related or associated by chance, requiring different diagnostic and therapeutic approaches. In this review we analyze and summarize the actual knowledge about vestibular migraine (VM), focusing on the new concepts proposed by the International Classification of Headache Disorders 3-beta and by the Bárány Society and also addressing the former concepts, which are still present in clinical practice...
2016: Behavioural Neurology
https://www.readbyqxmd.com/read/28074078/pediatric-traumatic-brain-injury-and-autism-elucidating-shared-mechanisms
#3
REVIEW
Rahul Singh, Ryan C Turner, Linda Nguyen, Kartik Motwani, Michelle Swatek, Brandon P Lucke-Wold
Pediatric traumatic brain injury (TBI) and autism spectrum disorder (ASD) are two serious conditions that affect youth. Recent data, both preclinical and clinical, show that pediatric TBI and ASD share not only similar symptoms but also some of the same biologic mechanisms that cause these symptoms. Prominent symptoms for both disorders include gastrointestinal problems, learning difficulties, seizures, and sensory processing disruption. In this review, we highlight some of these shared mechanisms in order to discuss potential treatment options that might be applied for each condition...
2016: Behavioural Neurology
https://www.readbyqxmd.com/read/28053370/antiepileptic-drug-nonadherence-and-its-predictors-among-people-with-epilepsy
#4
Asmamaw Getnet, Solomon Meseret Woldeyohannes, Lulu Bekana, Tesfa Mekonen, Wubalem Fekadu, Melak Menberu, Solomon Yimer, Adisu Assaye, Amsalu Belete, Habte Belete
Introduction. Antiepileptic drugs are effective in the treatment of epilepsy to the extent that about 70% of people with epilepsy can be seizure-free, but poor adherence to medication is major problem to sustained remission and functional restoration. The aim of this study was to assess the prevalence and associated factors of antiepileptic drug nonadherence. Methods. Cross-sectional study was conducted on 450 individuals who were selected by systematic random sampling method. Antiepileptic drug nonadherence was measured by Morisky Medication Adherence Scale (MMAS) and logistic regression was used to look for significant associations...
2016: Behavioural Neurology
https://www.readbyqxmd.com/read/28042202/influence-of-binasal-and-uninasal-inhalations-of-essential-oil-of-abies-koreana-twigs-on-electroencephalographic-activity-of-human
#5
Min Seo, Kandhasamy Sowndhararajan, Songmun Kim
Objectives. The present work investigates the effect of essential oil from the twigs of Abies koreana on electroencephalographic (EEG) activity of human brain in order to understand the influence of binasal and uninasal inhalations. Methods. To accomplish this study, the essential oil from the twigs of A. koreana (AEO) was isolated by steam distillation and the EEG readings were recorded using QEEG-8 system from 8 grounding electrodes according to the International 10-20 System. Results. D-Limonene (25.29%), bornyl acetate (19...
2016: Behavioural Neurology
https://www.readbyqxmd.com/read/28042201/clinical-and-preclinical-cognitive-function-improvement-after-oral-treatment-of-a-botanical-composition-composed-of-extracts-from-scutellaria-baicalensis-and-acacia-catechu
#6
Mesfin Yimam, Bruce P Burnett, Lidia Brownell, Qi Jia
Dementia and cognitive impairment have become the major concerns worldwide due to a significantly aging population, increasing life span and lack of effective pharmacotherapy. In light of limited pharmaceutical drug choices and the socioeconomic implications of these conditions, the search for safe and effective alternatives from natural sources has gained many attractions within the medical food and dietary supplement industry. Two polyphenol extracts derived from roots of Scutellaria baicalensis and heartwoods of Acacia catechu containing free-B-ring flavonoids and flavans, respectively, were combined into a proprietary blend called UP326...
2016: Behavioural Neurology
https://www.readbyqxmd.com/read/27872512/a-systematic-review-of-research-on-autism-spectrum-disorders-in-sub-saharan-africa
#7
REVIEW
Amina Abubakar, Derrick Ssewanyana, Charles R Newton
The burden of autism spectrum disorders (ASDs) in sub-Saharan Africa (SSA) is not well known. We carried out a systematic review of the literature to identify published work from SSA. We have systematically searched four databases, namely, Medline, PsycINFO, CINAHL, and Child Development & Adolescent Studies, through EBSCO and identified studies from across SSA. Based on predefined inclusion criteria, 47 studies were included in this review. Most of the identified studies (74%) were conducted in only 2 African countries, that is, South Africa and Nigeria...
2016: Behavioural Neurology
https://www.readbyqxmd.com/read/27847404/neuroprotective-effects-of-bone-marrow-mesenchymal-stem-cells-on-bilateral-common-carotid-arteries-occlusion-model-of-cerebral-ischemia-in-rat
#8
Bagher Pourheydar, Sara Soleimani Asl, Mostafa Azimzadeh, Adel Rezaei Moghadam, Asghar Marzban, Mehdi Mehdizadeh
Cell therapy is the most advanced treatment of the cerebral ischemia, nowadays. Herein, we discuss the neuroprotective effects of bone marrow mesenchymal stem cells (BMSCs) on rat hippocampal cells following intravenous injection of these cells in an ischemia-reperfusion model. Adult male Wistar rats were divided into 5 groups: control, sham (surgery without blockage of common carotid arteries), ischemia (common carotid arteries were blocked for 30 min prior to reperfusion), vehicle (7 days after ischemia PBS was injected via the tail vein), and treatment (injections of BMSC into the tail veins 7 days after ischemia)...
2016: Behavioural Neurology
https://www.readbyqxmd.com/read/27843197/a-correlative-classification-study-of-schizophrenic-patients-with-results-of-clinical-evaluation-and-structural-magnetic-resonance-images
#9
Wen-Lin Chu, Min-Wei Huang, Bo-Lin Jian, Chih-Yao Hsu, Kuo-Sheng Cheng
Patients with schizophrenia suffer from symptoms such as hallucination and delusion. There are currently a number of publications that discuss the treatment, diagnosis, prognosis, and damage in schizophrenia. This study utilized joint independent component analysis to process the images of GMV and WMV and incorporated the Wisconsin card sorting test (WCST) and the positive and negative syndrome scale (PANSS) to examine the correlation of obtained brain characteristics. We also used PANSS score to classify schizophrenic patients into acute and subacute cases, to analyze the brain structure differences...
2016: Behavioural Neurology
https://www.readbyqxmd.com/read/27821976/recent-advances-in-the-understanding-of-vestibular-migraine
#10
REVIEW
Jong-Hee Sohn
Approximately 1% of the general population and 10% of patients with migraine suffer from vestibular migraine (VM). However, this condition remains relatively unknown; therefore, it is often underdiagnosed despite the recent adoption of international diagnostic criteria for VM. The diagnosis of VM is based on the symptoms, degree, frequency, and duration of the vestibular episodes, a history of migraine, the temporal association of migraine symptoms with vestibular episodes in at least 50% of cases, and the exclusion of other causes...
2016: Behavioural Neurology
https://www.readbyqxmd.com/read/27688599/cognitive-impairment-involving-social-cognition-in-spg4-hereditary-spastic-paraplegia
#11
Ludivine Chamard, Sabrina Ferreira, Alexa Pijoff, Manon Silvestre, Eric Berger, Eloi Magnin
Objectives. To describe cognitive assessment including social cognition in SPG4 patients. Methods. We reported a series of nine patients with SPG4 mutation with an extensive neuropsychological examination including social cognition assessment. Results. None of our patients presented with mental retardation or dementia. All presented with mild cognitive impairment with a high frequency of attention deficit (100%), executive disorders (89%), and social cognition impairment (78%). An asymptomatic patient for motor skills presented with the same cognitive profile...
2016: Behavioural Neurology
https://www.readbyqxmd.com/read/27660396/stress-recovery-effects-of-high-and-low-frequency-amplified-music-on-heart-rate-variability
#12
Yoshie Nakajima, Naofumi Tanaka, Tatsuya Mima, Shin-Ichi Izumi
Sounds can induce autonomic responses in listeners. However, the modulatory effect of specific frequency components of music is not fully understood. Here, we examined the role of the frequency component of music on autonomic responses. Specifically, we presented music that had been amplified in the high- or low-frequency domains. Twelve healthy women listened to white noise, a stress-inducing noise, and then one of three versions of a piece of music: original, low-, or high-frequency amplified. To measure autonomic response, we calculated the high-frequency normalized unit (HFnu), low-frequency normalized unit, and the LF/HF ratio from the heart rate using electrocardiography...
2016: Behavioural Neurology
https://www.readbyqxmd.com/read/27651559/the-intimate-relationship-between-vestibular-migraine-and-meniere-disease-a-review-of-pathogenesis-and-presentation
#13
REVIEW
Yuan F Liu, Helen Xu
Vestibular migraine (VM) has only recently been recognized as a distinct disease entity. One reason is that its symptoms overlap greatly with those of other vestibular disorders, especially Meniere disease (MD). The pathophysiology of neither VM nor MD is entirely elucidated. However, there are many theories linking migraine to both disorders. We reviewed the current understanding of migraine, VM, and MD and described how VM and MD are similar or different from each other in terms of pathophysiology and presentation, including hypotheses that the two share a common etiology and/or are variants of the same disease...
2016: Behavioural Neurology
https://www.readbyqxmd.com/read/27635114/are-theory-of-mind-skills-in-people-with-epilepsy-related-to-how-stigmatised-they-feel-an-exploratory-study
#14
A J Noble, A Robinson, A G Marson
Feelings of stigma are one of the main burdens reported by people with epilepsy (PWE). Adults with temporal or frontal lobe epilepsy and children with idiopathic generalised epilepsy are at risk of Theory of Mind (ToM) deficits. ToM refers to social cognitive skills, including the ability to understand the thoughts, intentions, beliefs, and emotions of others. It has been proffered that ToM deficits may contribute to the feelings of stigma experienced by PWE. In this study we tested this for the first time...
2016: Behavioural Neurology
https://www.readbyqxmd.com/read/27555668/degraded-impairment-of-emotion-recognition-in-parkinson-s-disease-extends-from-negative-to-positive-emotions
#15
Chia-Yao Lin, Yi-Min Tien, Jong-Tsun Huang, Chon-Haw Tsai, Li-Chuan Hsu
Because of dopaminergic neurodegeneration, patients with Parkinson's disease (PD) show impairment in the recognition of negative facial expressions. In the present study, we aimed to determine whether PD patients with more advanced motor problems would show a much greater deficit in recognition of emotional facial expressions than a control group and whether impairment of emotion recognition would extend to positive emotions. Twenty-nine PD patients and 29 age-matched healthy controls were recruited. Participants were asked to discriminate emotions in Experiment  1 and identify gender in Experiment  2...
2016: Behavioural Neurology
https://www.readbyqxmd.com/read/27504054/the-efficacy-and-safety-of-antipsychotic-medications-in-the-treatment-of-psychosis-in-patients-with-parkinson-s-disease
#16
REVIEW
Nevena Divac, Radan Stojanović, Katarina Savić Vujović, Branislava Medić, Aleksandar Damjanović, Milica Prostran
Psychotic symptoms are present in up to 50% of patients with Parkinson's disease. These symptoms have detrimental effects on patients' and caregivers' quality of life and may predict mortality. The pathogenesis of psychotic symptoms in Parkinson's disease is complex, but the use of dopaminergic medications is one of the risk factors. The treatment of psychotic symptoms in Parkinson's disease is complicated due to the ability of antipsychotic medications to worsen motor symptoms. The efficacy of clozapine in the treatment of psychosis in patients with Parkinson's disease has been confirmed in several clinical trials; however, the adverse effects and the necessity of blood count monitoring are the reasons why the use of this drug is challenging...
2016: Behavioural Neurology
https://www.readbyqxmd.com/read/27462136/the-effect-of-chronic-alprazolam-intake-on-memory-attention-and-psychomotor-performance-in-healthy-human-male-volunteers
#17
Zahid Sadek Chowdhury, Mohammed Monzur Morshed, Mohammad Shahriar, Mohiuddin Ahmed Bhuiyan, Sardar Mohd Ashraful Islam, Muhammad Shahdaat Bin Sayeed
Alprazolam is used as an anxiolytic drug for generalized anxiety disorder and it has been reported to produce sedation and anterograde amnesia. In the current study, we randomly divided 26 healthy male volunteers into two groups: one group taking alprazolam 0.5 mg and the other taking placebo daily for two weeks. We utilized the Cambridge Neuropsychological Test Automated Battery (CANTAB) software to assess the chronic effect of alprazolam. We selected Paired Associates Learning (PAL) and Delayed Matching to Sample (DMS) tests for memory, Rapid Visual Information Processing (RVP) for attention, and Choice Reaction Time (CRT) for psychomotor performance twice: before starting the treatment and after the completion of the treatment...
2016: Behavioural Neurology
https://www.readbyqxmd.com/read/27418720/pain-assessment-in-neurodegenerative-diseases
#18
Marina de Tommaso, Lars Arendt-Nielsen, Ruth Defrin, Miriam Kunz, Gisele Pickering, Massimiliano Valeriani
No abstract text is available yet for this article.
2016: Behavioural Neurology
https://www.readbyqxmd.com/read/27413249/sleep-deprivation-influences-circadian-gene-expression-in-the-lateral-habenula
#19
Beilin Zhang, Yanxia Gao, Yang Li, Jing Yang, Hua Zhao
Sleep is governed by homeostasis and the circadian clock. Clock genes play an important role in the generation and maintenance of circadian rhythms but are also involved in regulating sleep homeostasis. The lateral habenular nucleus (LHb) has been implicated in sleep-wake regulation, since LHb gene expression demonstrates circadian oscillation characteristics. This study focuses on the participation of LHb clock genes in regulating sleep homeostasis, as the nature of their involvement is unclear. In this study, we observed changes in sleep pattern following sleep deprivation in LHb-lesioned rats using EEG recording techniques...
2016: Behavioural Neurology
https://www.readbyqxmd.com/read/27340339/validation-of-the-turkish-version-of-the-rapid-eye-movement-sleep-behavior-disorder-questionnaire
#20
Itır Tarı Cömert, Zerrin Pelin, Tolga Arıcak, Saadet Yapan
The aim of this study was to assess the validity and reliability of a Turkish version of the rapid eye movement sleep behavior disorder questionnaire (the RBDSQ-T) for identifying patients with rapid eye movement sleep behavior disorder (RBD) and to ensure that this tool can be applied in Turkish language. Three groups were enrolled to validate the RBDSQ-T: 78 healthy controls, 17 patients previously diagnosed with RBD, and 28 patients with obstructive sleep apnea syndrome (OSAS). Based on a cut-off score of five, the RBDSQ-T was able to discriminate RBD patients from healthy controls with sensitivity of 100% and specificity of 87%...
2016: Behavioural Neurology
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