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Behavioural Neurology

Lin Chen, Jialu Huang, Suxia Wang, Hong Ran, Lan Wen, Kangning Chen, Zhenhua Zhou
Background: Carotid artery morphological variations (CAMV) are common variations on medical imaging; the effects of CAMV on cognition were still unknown. This study is aimed at investigating whether carotid artery morphological variations (CAMV) cause cognitive impairment. Methods: Hospitalized patients from March 2017 to October 2017 who underwent digital subtract angiography (DSA) were divided into non-CAMV group, T-type group, K-type group, and C-type group according to their carotid artery morphology...
2018: Behavioural Neurology
Heng Yang, Wei Ni, Hanqiang Jiang, Yu Lei, Jiabin Su, Yuxiang Gu, Liangfu Zhou
Objectives: To investigate the role of Scriptaid in reducing brain injury after intracerebral hemorrhage (ICH) in mice. Methods: An ICH model was constructed by injecting autologous blood into the right basal ganglia in mice. The animals were administered 3.5 mg/kg of Scriptaid intraperitoneally after ICH. The hematoma volume and hemoglobin level were measured to examine hematoma resolution. A behavior test and brain edema and white matter injury examinations indicated brain injury after ICH...
2018: Behavioural Neurology
Daqiang Ke, Feng Zhou, Hui Liang, Yang Xu, Haiyan Lou
Intracranial hemorrhage or microbleeds and leukoaraiosis have an overlap in biology. Hyperlipidemia may reduce the risk of ICH or cerebral microbleeds; studies focusing on the relationship between different lipid profiles and severity of periventricular hyperintensities (PVH) and subcortical white matter lesions (SWMLs) in the cerebral small vessel disease are limited. Methods . Patients with recent first lacunar infarct were recruited. PVH and SWMLs were accessed on MRI with the Fazekas scale, and lipid levels were measured...
2018: Behavioural Neurology
Bei-Lei Zhu, Chen-Long Xie, Ning-Ning Hu, Xin-Bo Zhu, Chun-Feng Liu
Background and Purpose: The aim of this study was to explore the role of DL-3-n-butylphthalide (NBP) in cerebral ischemia-reperfusion injury (CIRI) mice model. The involvement of extracellular signal-regulated kinase (ERK) signaling pathway was also investigated. Methods: All mice were divided into five groups: sham-operated group, CIRI group, NBP pretreatment group, NBP treatment group, and NBP pretreatment + treatment group. The CIRI mice model was established by the use of the Pulsinelli four-vessel occlusion method...
2018: Behavioural Neurology
Ying-Jui Ho, Jun-Cheng Weng, Chih-Li Lin, Mei-Shiuan Shen, Hsin-Hua Li, Wen-Chieh Liao, Nu-Man Tsai, Ching-Sui Hung, Te-Jen Lai, I-Yen Lee
Dementia with Lewy bodies (DLB) is characterized by neuronal deficits and α -synuclein inclusions in the brain. Ceftriaxone (CEF), a β -lactam antibiotic, has been suggested as a therapeutic agent in several neurodegenerative disorders for its abilities to counteract glutamate-mediated toxicity and to block α -synuclein polymerization. By using manganese-enhanced magnetic resonance imaging (MEMRI) and immunohistochemistry, we measured the effects of CEF on neuronal activity and α -synuclein accumulation in the brain in a DLB rat model...
2018: Behavioural Neurology
Niki Pandria, Alkinoos Athanasiou, Nikos Terzopoulos, Evangelos Paraskevopoulos, Maria Karagianni, Charis Styliadis, Chrysoula Kourtidou-Papadeli, Athanasia Pataka, Evgenia Lymperaki, Panagiotis D Bamidis
Smoking and stress cooccur in different stages of a nicotine addiction cycle, affecting brain function and showing additive impact on different physiological responses. Resting-state functional connectivity has shown potential in identifying these alterations. Nicotine addiction has been associated with detrimental effects on functional integrity of the central nervous system, including the organization of resting-state networks. Prolonged stress may result in enhanced activation of the default mode network (DMN)...
2018: Behavioural Neurology
Francesca Trojsi, Foteini Christidi, Raffaella Migliaccio, Hernando Santamaría-García, Gabriella Santangelo
No abstract text is available yet for this article.
2018: Behavioural Neurology
Yang Xu, Ji Zhang, Lingsong Ma, Shoucai Zhao, Shizun Li, Tingting Huang, Zhaohu Chu
Necroptosis is the best-described form of regulated necrosis at present, which is widely recognized as a component of caspase-independent cell death mediated by the concerted action of receptor-interacting protein kinase 1 (RIPK1) and receptor-interacting protein kinase 3 (RIPK3). Mixed-lineage kinase domain-like (MLKL) was phosphorylated by RIPK3 at the threonine 357 and serine 358 residues and then formed tetramers and translocated onto the plasma membrane, which destabilizes plasma membrane integrity leading to cell swelling and membrane rupture...
2018: Behavioural Neurology
Gaiqing Wang, Tong Li, Shu-Na Duan, Liang Dong, Xin-Gang Sun, Fang Xue
Background and Purpose: PPAR- γ is a transcriptional factor which is associated with promoting hematoma clearance and reducing neurological dysfunction after intracerebral hemorrhage (ICH). Haptoglobin- (Hp-) hemoglobin- (Hb-) CD163 acts as a main pathway to Hb scavenging after ICH. The effect of PPAR- γ on the Hp-Hb-CD163 signaling pathway has not been reported. We hypothesized that PPAR- γ might protect against ICH-induced neuronal injury via activating the Hp-Hb-CD163 pathway in a rat ICH model...
2018: Behavioural Neurology
Takumi Takeuchi, Masahito Takahashi, Kazuhiko Satomi, Hideaki Ohne, Atsushi Hasegawa, Shunsuke Sato, Shoichi Ichimura
[This corrects the article DOI: 10.1155/2017/7514681.].
2018: Behavioural Neurology
Yao-Chin Wang, Po-An Tai, Tahmina Nasrin Poly, Md Mohaimenul Islam, Hsuan-Chia Yang, Chieh-Chen Wu, Yu-Chuan Jack Li
Antidepressants are the most commonly and widely used medication for its effectiveness in the treatment of anxiety and depression. A few epidemiological studies have documented that antidepressant is associated with increased risk of dementia so far. Here, our aim is to assess the association between antidepressant use and risk of dementia in elderly patients. We searched articles through MEDLINE, EMBASE, Google, and Google Scholar from inception to December 1, 2017, that reported on the association between antidepressant use and dementia risk...
2018: Behavioural Neurology
Chuo-Yu Lee, Shih-Jung Cheng, Hui-Chi Lin, Yu-Lu Liao, Pei-Hao Chen
Dementia with Lewy bodies (DLB) is a complex, multisymptom disorder. When making decisions regarding the treatment of DLB, the patient's quality of life (QoL) should always be the main consideration. To our knowledge, this is the first review article focusing on the QoL in DLB patients. We searched the PubMed database using the keywords "quality of life" and "dementia with Lewy bodies." Previously, no specific instrument had been developed for assessing the QoL in DLB patients. Patients with DLB have a decreased QoL compared to patients with Alzheimer's disease, which is reportedly caused by several factors including level of independence in instrumental activities of daily living, whether the patient is living with the caregiver, apathy, delusion, and dysautonomia...
2018: Behavioural Neurology
Masao Omori, Satoshi Shibuya, Tsuyoshi Nakajima, Takashi Endoh, Shinya Suzuki, Shun Irie, Ryohei Ariyasu, Satoshi Unenaka, Hideto Sano, Kazutaka Igarashi, Shoichi Ichimura, Yukari Ohki
Cervical myelopathy (CM) caused by spinal cord compression can lead to reduced hand dexterity. However, except for the 10 sec grip-and-release test, there is no objective assessment system for hand dexterity in patients with CM. Therefore, we evaluated the hand dexterity impairment of patients with CM objectively by asking them to perform a natural prehension movement. Twenty-three patients with CM and 30 age-matched controls were asked to reach for and grasp a small object with their right thumb and index finger and to subsequently lift and hold it...
2018: Behavioural Neurology
Claire Meyniel, Dalila Samri, Farah Stefano, Joel Crevoisier, Florence Bonté, Raffaella Migliaccio, Laure Delaby, Anne Bertrand, Marie Odile Habert, Bruno Dubois, Bahram Bodaghi, Stéphane Epelbaum
We evaluated the cognitive status of visually impaired patients referred to low vision rehabilitation (LVR) based on a standard cognitive battery and a new evaluation tool, named the COGEVIS, which can be used to assess patients with severe visual deficits. We studied patients aged 60 and above, referred to the LVR Hospital in Paris. Neurological and cognitive evaluations were performed in an expert memory center. Thirty-eight individuals, 17 women and 21 men with a mean age of 70.3 ± 1.3 years and a mean visual acuity of 0...
2018: Behavioural Neurology
Po-Chi Chan, Hsun-Hua Lee, Chien-Tai Hong, Chaur-Jong Hu, Dean Wu
Rapid eye movement sleep behavior disorder (RBD) is a parasomnia, with abnormal dream-enacting behavior during the rapid eye movement (REM) sleep. RBD is either idiopathic or secondary to other neurologic disorders and medications. Dementia with Lewy bodies (DLB) is the third most common cause of dementia, and the typical clinical presentation is rapidly progressive cognitive impairment. RBD is one of the core features of DLB and may occur either in advance or simultaneously with the onset of DLB. The association between RBD with DLB is widely studied...
2018: Behavioural Neurology
Jie Qu, Hengli Zhao, Qiang Li, Pengyu Pan, Kang Ma, Xin Liu, Hua Feng, Yujie Chen
Background: Mammalian sterile 20-like kinase 1 (MST1), the key component of the Hippo-YAP pathway, exhibits an important role in the pathophysiological process of various neurological disorders, including ischemic stroke and spinal cord injury. However, during subarachnoid hemorrhage, the involvement of MST1 in the pathophysiology of early brain injury remains unknown. Methods: We employed intravascular filament perforation to establish the subarachnoid hemorrhage (SAH) mouse model...
2018: Behavioural Neurology
Yanhua Qin, Weiming Hu, Yang Yang, Zhiying Hu, Weiyun Li, Marong Fang
Aberrant production of nitric oxide following inducible nitric oxide synthase (iNOS) expression has been implicated in cell death and contributes to ischemic brain injury. Tetrahydrobiopterin (BH4) is an essential cofactor of NOS activity. Herein, we evaluated antiapoptotic and anti-inflammatory effects of diamino-6-hydroxypyrimidine (DAHP), a guanosine 5'-triphosphate cyclohydrolase 1 (GTPCH1) inhibitor on focal cerebral ischemia-reperfusion injury by middle cerebral artery occlusion and reperfusion (MCAO) and investigated the underlying mechanism...
2018: Behavioural Neurology
Rui Lan, Yong Zhang, Tao Wu, Yun-Zhi Ma, Bao-Qi Wang, Hai-Zhong Zheng, Ya-Na Li, Yan Wang, Chun-Qing Gu, Ji-Tao Wu
We investigated whether Xiao-Xu-Ming decoction reduced mitophagy activation and kept mitochondrial function in cerebral ischemia-reperfusion injury. Rats were randomly divided into 5 groups: sham, ischemia and reperfusion (IR), IR plus XXMD (60 g/kg/day) (XXMD60), IR plus cyclosporin A (10 mg/kg/day) (CsA), and IR plus vehicle (Vehicle). Focal cerebral ischemia and reperfusion models were induced by middle cerebral artery occlusion (MCAO). Cerebral infarct areas were measured by triphenyl tetrazolium chloride staining...
2018: Behavioural Neurology
Sheng-Kung Yang, Weishan Chen, Chun-Hsien Su, Chung-Hsiang Liu
Background and Aims: Dementia with Lewy bodies (DLB) is the third most common form of dementia. Epidemiological studies of DLB in Taiwan are scarce. In this study, we estimated the incidence of DLB and comorbidity in the population of Taiwan. Methods: Data were obtained from the Taiwan National Health Insurance Research Database (NHIRD). DLB patients between 2000 and 2013 were enrolled in assessments of incidence and comorbidity. Results: The incidence of DLB was shown to be 7...
2018: Behavioural Neurology
Chih-Kuang Cheng, Yu-Chien Tsao, Yuan-Chih Su, Fung-Chang Sung, Hsu-Chih Tai, Woon-Man Kung
Background: Alzheimer's disease (AD) and dementia with Lewy bodies (DLB) share many risk factors. Evidence suggests that metabolic risk factors are important to AD; however, their association with DLB is unclear. The risk of cardiovascular diseases (CVD) associated with AD and DLB is also uncertain. Thus, this nationwide, population-based study was designed to evaluate the metabolic and CVD risks in AD and DLB. Materials and Methods: Data were obtained from the Taiwan National Health Insurance Research Database...
2018: Behavioural Neurology
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