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Behavioural Neurology

Nicholas P Ryan, Laura Scott, Maryanne McPhee, Susan Mathers, Marie-Claire Davis, Roxanne Maule, Fiona Fisher
Objectives: Behavioural and psychological symptoms of dementia (BPSD) cause significant distress to both aged care residents and staff. Despite the high prevalence of BPSD in progressive neurological diseases (PNDs) such as multiple sclerosis, Huntington's disease, and Parkinson's disease, the utility of a structured clinical protocol for reducing BPSD has not been systematically evaluated in PND populations. Method: Staff ( n = 51) and individuals with a diagnosis of PND ( n = 13) were recruited into the study, which aimed to evaluate the efficacy of a PND-specific structured clinical protocol for reducing the impact of BPSD in residential aged care (RAC) and specialist disability accommodation (SDA) facilities...
2018: Behavioural Neurology
Serpil Özmen, Afife Yurttaş
The aim of this study was to determine the care burden of caregivers of patients with multiple sclerosis in Turkey. This descriptive study was conducted with 92 caregivers. To collect data, information form and Zarit Caregiver Burden Interview (ZCBI) were used. Most of the caregivers (65.2%) were females and 71.7% of them were married. The average age of caregivers was 38 and above. The mean ZCBI score of caregivers was 25.44 ± 9.50. The ZCBI score was significantly higher in caregivers providing care for more than six years (28...
2018: Behavioural Neurology
Xiaojing Long, Chunxiang Jiang, Lijuan Zhang
Identifying subjects with mild cognitive impairment (MCI) who may probably progress to Alzheimer's disease (AD) is important for better understanding the disease mechanisms and facilitating early treatments. In addition to the direct volumetric and thickness measurement based on high-resolution magnetic resonance imaging (MRI), hemispheric asymmetry could be a potential index to detect morphological variations in MCI patients with a high risk of conversion to AD. The present study collected a set of longitudinal MRI data from 53 MCI converters and nonconverters and investigated the asymmetry differences between groups...
2018: Behavioural Neurology
Pablo Cruz Gonzalez, Kenneth N K Fong, Ted Brown
Objective: The aim of this pilot study was to investigate whether the use of anodal transcranial direct current stimulation (tDCS) on the left dorsolateral prefrontal cortex could boost the effects of a cognitive stimulation (CS) programme using a tablet on five older adults with mild cognitive impairment (MCI). Method: A single-subject study of A-B-C-A design was used. After the baseline with the administration of CS (phase A), a sham treatment with CS was applied (B)...
2018: Behavioural Neurology
Caroline Neely, Christina Lane, Julio Torres, Jane Flinn
Environmental factors play a significant role in well-being of laboratory animals. Regulations and guidelines recommend, if not require, that stressors such as bright lighting, smells, and noises are eliminated or reduced to maximize animal well-being. A factor that is often overlooked is handling and how researchers interact with their animals. Researchers, lab assistants, and husbandry staff in animal facilities may use inconsistent handling methods when interacting with rodents, but humans should be considered a part of the animal's social environment...
2018: Behavioural Neurology
Andrew R Carr, Mark M Ashla, Elvira E Jimenez, Mario F Mendez
Objective: Although emotional blunting is a core feature of behavioral variant frontotemporal dementia (bvFTD), there are no practical clinical measures of emotional expression for the early diagnosis of bvFTD. Method: Three age-matched groups (bvFTD, Alzheimer's disease (AD), and healthy controls (HC)) of eight participants each were presented with real-life vignettes varying in emotional intensity (high versus low) with either negative or positive outcomes. This study evaluated verbal (self-reports of distress) and visual (presence or absence of facial affect) measures of emotional expression during the vignettes...
2018: Behavioural Neurology
Marcia Belas Dos Santos, Clarissa Barros de Oliveira, Arly Dos Santos, Cristhiane Garabello Pires, Viviana Dylewski, Ricardo Mario Arida
Objectives: To assess the influence of RAGT on balance, coordination, and functional independence in activities of daily living of chronic stroke survivors with ataxia at least one year of injury. Methods: It was a randomized controlled trial. The patients were allocated to either therapist-assisted gait training (TAGT) or robotic-assisted gait training (RAGT). Both groups received 3 weekly sessions of physiotherapy with an estimated duration of 60 minutes each and prescribed home exercises...
2018: Behavioural Neurology
Paul Bosch, Mauricio Herrera, Julio López, Sebastián Maldonado
We have developed a new methodology for examining and extracting patterns from brain electric activity by using data mining and machine learning techniques. Data was collected from experiments focused on the study of cognitive processes that might evoke different specific strategies in the resolution of math problems. A binary classification problem was constructed using correlations and phase synchronization between different electroencephalographic channels as characteristics and, as labels or classes, the math performances of individuals participating in specially designed experiments...
2018: Behavioural Neurology
Natalya P Bondar, Arina A Lepeshko, Vasiliy V Reshetnikov
Stressful events in an early postnatal period have critical implications for the individual's life and can increase later risk for psychiatric disorders. The aim of this study was to investigate the influence of early-life stress on the social behavior of adult male and female mice. C57Bl/6 mice were exposed to maternal separation (MS, 3 h once a day) or handling (HD, 15 min once a day) on postnatal day 2 through 14. Adult male and female mice were tested for social behavior in the social interaction test and for individual behavior in the plus-maze and open-field tests...
2018: Behavioural Neurology
Melody N Mickens, Paul B Perrin, Adriana Aguayo, Brenda Rabago, Miguel A Macías-Islas, Juan Carlos Arango-Lasprilla
Individuals with multiple sclerosis (MS), especially those living in Latin America, often require assistance from family caregivers throughout the duration of the disease. Previous research suggests that family caregivers may experience positive and negative outcomes from providing care to individuals with MS, but few studies have examined the unmet needs of individuals providing care to family members with MS and how these unmet needs may mediate the relationship between MS symptoms and caregiver mental health...
2018: Behavioural Neurology
Lambros Messinis, Panagiotis Papathanasopoulos, Mary H Kosmidis, Grigorios Nasios, Maria Kambanaros
No abstract text is available yet for this article.
2018: Behavioural Neurology
Grigorios Nasios, Lambros Messinis, Efthimios Dardiotis, Panagiotis Papathanasopoulos
Multiple sclerosis (MS) affects cognition in the majority of patients. A major aspect of the disease is brain volume loss (BVL), present in all phases and types (relapsing and progressive) of the disease and linked to both motor and cognitive disabilities. Due to the lack of effective pharmacological treatments for cognition, cognitive rehabilitation and other nonpharmacological interventions such as repetitive transcranial magnetic stimulation (rTMS) have recently emerged and their potential role in functional connectivity is studied...
2018: Behavioural Neurology
Lambros Messinis, Grigorios Nasios, Mary H Kosmidis, Petros Zampakis, Sonia Malefaki, Katerina Ntoskou, Anastasia Nousia, Christos Bakirtzis, Nikolaos Grigoriadis, Philippos Gourzis, Panagiotis Papathanasopoulos
Cognitive impairment is frequently encountered in multiple sclerosis (MS) affecting between 40-65% of individuals, irrespective of disease duration and severity of physical disability. In the present multicenter randomized controlled trial, fifty-eight clinically stable RRMS patients with mild to moderate cognitive impairment and relatively low disability status were randomized to receive either computer-assisted (RehaCom) functional cognitive training with an emphasis on episodic memory, information processing speed/attention, and executive functions for 10 weeks (IG; n = 32) or standard clinical care (CG; n = 26)...
2017: Behavioural Neurology
Atsushi Ishii, Hiroshi Ihara, Hiroyuki Ogata, Masayuki Sayama, Masao Gito, Nobuyuki Murakami, Tadayuki Ayabe, Yuji Oto, Asami Takahashi, Toshiro Nagai
The effects of age and genotype were examined, with regard to the severity of aberrant, autistic, and food-related behaviors in Prader-Willi syndrome (PWS), with an emphasis on the contrast between adolescents and young adults. The Aberrant Behavior Checklist Japanese version (ABC-J), the Food Related Problem Questionnaire (FRPQ), and the Pervasive Developmental Disorders Autism Society Japan Rating Scale (PARS) were administered to 65 PWS patients, including 20 adolescents (ages 12 to 17) and 45 young adults (ages 18 to 29)...
2017: Behavioural Neurology
Ozgul Ekmekci
Multiple sclerosis (MS) is an inflammatory demyelinating and neurodegenerative disease. Although cognitive impairment has been well established in adult patients with MS, its occurrence in patients with pediatric-onset MS has recently been reported. In this review, I discuss the main features of cognitive impairment in pediatric MS as determined by long-term follow-up studies, neuropsychiatric test batteries, and the results of neuroradiological imaging studies that investigated the pathogenesis of pediatric MS...
2017: Behavioural Neurology
Masato Kasagi, Zirui Huang, Kosuke Narita, Hitoshi Shitara, Tomokazu Motegi, Yusuke Suzuki, Kazuyuki Fujihara, Sean Tanabe, Hirotaka Kosaka, Koichi Ujita, Masato Fukuda, Georg Northoff
The scale-free dynamics of human brain activity, characterized by an elaborate temporal structure with scale-free properties, can be quantified using the power-law exponent (PLE) as an index. Power laws are well documented in nature in general, particularly in the brain. Some previous fMRI studies have demonstrated a lower PLE during cognitive-task-evoked activity than during resting state activity. However, PLE modulation during cognitive-task-evoked activity and its relationship with an associated behavior remain unclear...
2017: Behavioural Neurology
Xiaoling Hu, Ting Zhao, Jun Yao, Yu Kuang, Yuan Yang
No abstract text is available yet for this article.
2017: Behavioural Neurology
C Guijarro-Castro, Y Aladro-Benito, A Sánchez-Musulim, A Belen-Caminero, I Pérez Molina, I Gómez-Moreno, L Gómez-Romero, J Millán-Pascual, M J Laredo, M Cerezo-García
Introduction: Cognitive impairment (CI) affects 40-65% of patients with multiple sclerosis (MS). Few studies address telematic cognitive stimulation (TCS) in MS. The objective of this study is to evaluate the efficacy and impact of telestimulation or distance cognitive stimulation (TCS), with and without the support of face-to-face cognitive stimulation (FCS) in cognitive impairment in MS. Methods: Multicentre, prospective, randomised, controlled study. We will include 98 MS patients with EDSS ≤ 6, symbol digit modality test (SDMT) ≤ Pc 25, and Multiple Sclerosis Neuropsychological Screening Questionnaire (MSNQ) > 26 points...
2017: Behavioural Neurology
Linlin Zhang, Yi Feng, Wenliang Ji, Jianzhang Liu, Kun Liu
The aim of the present study is to evaluate the effect of voluntary wheel running on striatal dopamine level and behavior of cognition and emotion in molar loss rats. Twenty-four Sprague-Dawley rats were enrolled in this study and randomly divided into following 4 groups: control group (C group), molar loss group (ML group), 1-week physical exercise before molar loss group (1W-ML group), and 4-week physical exercise before molar loss group (4W-ML group). The rats both in 4W-ML and 1W-ML groups were placed in the voluntary running wheel in order to exercise for 4 weeks and 1 week, respectively...
2017: Behavioural Neurology
Chandran Ramakrishna, Mari S Golub, Abby Chiang, Teresa Hong, Markus Kalkum, Edouard M Cantin
Herpes simplex virus 1 (HSV) encephalitis (HSE) has serious neurological complications, involving behavioral and cognitive impairments that cause significant morbidity and a reduced quality of life. We showed that HSE results from dysregulated central nervous system (CNS) inflammatory responses. We hypothesized that CNS inflammation is casually involved in behavioral abnormalities after HSE and that treatment with ACV and pooled human immunoglobulin (IVIG), an immunomodulatory drug, would improve outcomes compared to mice treated with phosphate buffered saline (PBS) or ACV alone...
2017: Behavioural Neurology
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