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Indian Journal of Nephrology

A Kher, A Agarwal, P Jha, D Bansal, M Madken, A S Narula, R Khurana, V Kher
No abstract text is available yet for this article.
September 2018: Indian Journal of Nephrology
J Sethi, S Bagai, R Ramachandran, V Kumar, M Rathi, H S Kohli, K L Gupta
No abstract text is available yet for this article.
September 2018: Indian Journal of Nephrology
B Sangeeta Lakshmi, S V Padmavathi Devi, N Sai Sameera, A Sunnesh Reddy, R Ram, Vishnubotla Siva Kumar
No abstract text is available yet for this article.
September 2018: Indian Journal of Nephrology
Ö E Özmen, N Alici, B Topuz, M Akgül, E Akkuzu, Ö Akdemir, N Buyan, S Göral, Z Kaya
Renal infiltration in children with acute leukemia has been reported previously; however, it has rarely been described in association with atypical hemolytic uremic syndrome (aHUS). We present a case of 9-year-old boy who developed life-threatening aHUS in the 1st week of Burkitt leukemia/lymphoma diagnosis with renal infiltration. Complete resolution of aHUS was achieved after therapeutic plasma exchange. This is an uncommon complication of Burkitt leukemia/lymphoma in a pediatric case.
September 2018: Indian Journal of Nephrology
U Anandh, R Nikalji, A Parick
A 40-year-old female presented to the neurologist with gradually progressive weakness of distal and proximal muscles of both lower limbs and cramps for 2 years. She gave a history of similar illness in her paternal grandmother and her father. Her examination revealed bilateral foot drop and mild proximal muscle weakness. She was diagnosed to have peripheral neuropathy and subsequently treated conservatively. Over the next year, she noticed progressive swelling of both lower limb and frothy urine. A nephrology consultation was obtained, and a renal biopsy was done, which showed membranous nephropathy...
September 2018: Indian Journal of Nephrology
P Yadav, N Kumar, N Prasad, H Lal
Posttransplant lymphoproliferative disease (PTLD) is an uncommon complication of immunosuppression after solid organ transplantation. Early PTLD (<1 year after transplantation) is frequently found around the allograft, whereas late PTLD (>1 year after transplantation) does not have such a preference. 18-Fluorodeoxyglucose positron emission tomography-computed tomography (18 FDG PET-CT) has clinical significance in the evaluation of PTLD. 18 FDG PET-CT scan allows precise anatomic localization of FDG-avid lesions, hence helpful in staging of disease and evaluation of response to therapy...
September 2018: Indian Journal of Nephrology
H Satish, Sreejith Parameswaran, B H Srinivas, N G Rajesh, R Jayasurya, Rajesh Padhi, P S Priyamvada
Although the predominant component of acute allograft rejection is the T-cells, the milieu is not devoid of other inflammatory cells including plasma cells, eosinophils, and histiocytes. Apart from the CD8 T cell and CD4 T cell-FasL cytotoxicity, experimental models had proven a pivotal role of Th-2 cells in acute rejection, and these have been associated with marked tissue eosinophilia. Herein, we present a unique case of severe eosinophilic acute antibody-mediated rejection in a 22 years old deceased donor renal allograft recipient, within 4 days of transplantation without peripheral eosinophilia...
September 2018: Indian Journal of Nephrology
G Seralathan, A A Kurien
We describe a rare case of adenovirus interstitial nephritis in a 37-year-old man, 4 weeks following deceased donor renal transplantation. He presented with gross hematuria and acute graft dysfunction. A renal biopsy revealed necrotizing tubulointerstitial nephritis with intranuclear viral inclusions in the tubular epithelial cells. Immunohistochemistry and polymerase chain reaction confirmed adenovirus infection. Reduction in immunosuppression alone resulted in rapid improvement of graft function. Awareness of the clinical and characteristic biopsy findings may help establish the correct diagnosis, which is crucial as disseminated infection, if left untreated, is associated with a high mortality rate in renal allograft recipients...
September 2018: Indian Journal of Nephrology
G S Dhooria
Dropped head syndrome (DHS) is a relatively rare condition, with a broad differential diagnosis. We report here a case of infantile nephrotic syndrome with DHS caused by severe hypokalemia. Electrocardiogram showed flat T- and U-waves. Multiple factors including recurrent diarrhea, prolonged diuretic and corticosteroid use, hypomagnesemia, poor intake, and malnutrition caused hypokalemia in the case. Head drop and flaccid weakness resolved completely after potassium and magnesium supplementation. Potassium levels should be monitored and corrected promptly in these settings...
September 2018: Indian Journal of Nephrology
Anvesh Golla, R Goli, V K Nagalla, B V Kiran, D S B Raju, M S Uppin
Warfarin-related nephropathy also referred to as anticoagulant-related nephropathy (ACRN) is a type of acute kidney injury (AKI) that may be caused by excessive anticoagulation with warfarin and other anticoagulants. Despite the well-described histological entity, the clinical course and approach to ACRN in patients requiring life-long anticoagulation are however not well described in the literature. We report a 50-year-old Indian woman who was on prolonged anticoagulant therapy post-mitral valve replacement...
September 2018: Indian Journal of Nephrology
R W Thergaonkar, S Bhardwaj, A Sinha, A K Dinda, R Kumar, A Bagga, R N Srivastava, P Hari
Posttransplant lymphoproliferative disorder (PTLD) is reported in 1%-3% among pediatric renal allograft recipients. We report the experience of PTLD among pediatric renal allograft recipients at a pediatric nephrology center in North India. Four cases of PTLD were identified from among records of 95 pediatric renal allograft recipients over a period of 21 years. Constitutional and localizing symptoms were present in three patients each. The diagnosis was suggested on positron emission tomography in three patients and confirmed by histopathology in all...
September 2018: Indian Journal of Nephrology
M Surendra, S Raju, K K Mukku, C H Ved Prakash, N Raju
Cardiovascular disease is associated with increased mortality in dialysis population. However, there are very few studies that assessed the prevalence of coronary artery disease (CAD) at the time of initiation of hemodialysis (HD). The present study was aimed to assess the prevalence of CAD in end-stage renal disease (ESRD) patients at the time of initiation of HD and the risk factors for CAD in this population. This was a single-center retrospective study and included ESRD patients who underwent coronary angiography (CAG) at the time of initiation of HD...
September 2018: Indian Journal of Nephrology
G Chandramohan, T Dineshkumar, R Arul, M Seenivasan, J Dhanapriya, R Sakthirajan, T Balasubramaniyan, N Gopalakrishnan
Hypokalemic paralysis is an important and reversible cause of acute flaccid paralysis. The treating physician faces unique diagnostic and therapeutic challenges. We did a prospective study and included all patients with acute flaccid weakness and documented serum potassium of <3.5 mEq/L during the period between January 2009 and August 2015. We studied the incidence, etiology, clinical profile, and acid-base disturbances in patients presenting with hypokalemic paralysis and analyzed the significance of periodic and non-periodic forms of hypokalemic paralysis on patient's outcome...
September 2018: Indian Journal of Nephrology
V Chaitanya, N Harini Devi, M M Suchitra, P V L N Srinivasa Rao, B Vijaya Lakshmi, V Siva Kumar
The pleiotropic cytokine osteopontin (OPN) is found to be involved in the pathogenesis of both kidney and cardiovascular disease (CVD). We evaluated the relationship between OPN, other cardiovascular risk factors and carotid intima-media thickness (CIMT) in chronic kidney disease (CKD) (predialysis) patients. This is a 2-year cross-sectional prospective study involving 75 patients with CKD from stage 1 to stage 5 attending the nephrology outpatient department and 25 healthy controls. Routine biochemical parameters were analyzed on clinical chemistry Autoanalyzer Beckman Coulter DXC 600 Synchron, USA...
September 2018: Indian Journal of Nephrology
V Ramasubramanian, P Murlidharan, S Nambi, S Pavithra, S Puthran, T Petigara
Outpatient parenteral antimicrobial therapy (OPAT) programs are becoming an increasingly popular trend in clinical practice as they offer several benefits to both patients and health-care setups. While OPAT is an established clinical practice in the Western world, the concept itself is alien to patients in India as they prefer the security of hospitals to receive antibiotics over OPAT. We evaluated the clinical response and cost comparison of ertapenem under OPAT versus inpatient settings in patients with extended-spectrum beta-lactamase (ESBL)-positive acute pyelonephritis (APN) given the increasing importance of optimizing both hospital beds and overall cost of patient care in India...
September 2018: Indian Journal of Nephrology
S Kakde, S Alexander, V G David, S Jacob, A Mohapatra, A T Valson, B Gopal, C K Jacob, J Hephzibah, V Tamilarasi, S Varughese
Chronic Kidney Disease-Epidemiology Collaboration (CKD-EPI) equation is currently recommended for the estimation of glomerular filtration rate (GFR). This retrospective study aimed to evaluate the correlation between creatinine and cysC-based estimated GFRs and measured GFR in healthy adults. Consecutive healthy adults who were accepted as voluntary kidney donors at our center between January 2008 and December 2012 were included in the study. The 336 individuals who comprised the study population had a mean age of 41...
September 2018: Indian Journal of Nephrology
S I Almelkar, S Bethapudi, S N Rath
Renal transplant is treatment of choice for the patients with end stage renal disease. The kidney transplants are expensive and there are risks of immunological and infectious complications. We planned to develop an in vitro decellularized kidney scaffold model using sheep kidney. Kidney decellularization was carried out by perfusing chemical detergents such as sodium dodecyl sulfate (SDS), SDS and trypsin, and SDS and ethylenediaminetetraacetic acid solvent solution. Complete kidney was decellularized in 5 days by perfusing various chemical detergents in time-dependent intervals...
September 2018: Indian Journal of Nephrology
P M Sohal, A Goel, D Gupta, N Aslam, J Sandhu, J S Sandhu, E E John, D Sharma
Hemodialysis patients are at higher risk of cardiovascular disease due to traditional and dialysis-related risk factors. Our aim was to study the effects of hemodialysis on the corrected QT interval (QTc) and QTc dispersion in chronic kidney disease (CKD) without clinically manifest heart disease. Two hundred cases of CKD on chronic intermittent hemodialysis of >3 months' duration were included in the study. Twelve-lead electrocardiography and samples for serum creatinine, potassium, calcium, and magnesium were taken before and after dialysis...
September 2018: Indian Journal of Nephrology
(no author information available yet)
[This corrects the article on p. 220 in vol. 28, PMID: 29962673.].
July 2018: Indian Journal of Nephrology
G Kumar, M J Hamoudeh, N M Noureldin, I Alaqqad, N Airon, E Alkhasawneh
No abstract text is available yet for this article.
July 2018: Indian Journal of Nephrology
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