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Critical Reviews in Toxicology

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https://www.readbyqxmd.com/read/29431554/development-of-an-adverse-outcome-pathway-for-chemically-induced-hepatocellular-carcinoma-case-study-of-afb1-a-human-carcinogen-with-a-mutagenic-mode-of-action
#1
Martha M Moore, Rita S Schoeny, Richard A Becker, Kimberly White, Lynn H Pottenger
Adverse outcome pathways (AOPs) are frameworks starting with a molecular initiating event (MIE), followed by key events (KEs) linked by KE relationships (KERs), ultimately resulting in a specific adverse outcome. Relevant data for the pathway and each KE/KER are evaluated to assess biological plausibility, weight-of-evidence, and confidence. We aimed to describe an AOP relevant to chemicals directly inducing mutation in cancer critical gene(s), via the formation of chemical-specific pro-mutagenic DNA adduct(s), as an early critical step in tumor etiology...
February 12, 2018: Critical Reviews in Toxicology
https://www.readbyqxmd.com/read/29431551/lead-interacting-proteins-and-their-implication-in-lead-poisoning
#2
Iara Dantas de Souza, Abraão Silveira de Andrade, Rodrigo Juliani Siqueira Dalmolin
Lead is an important heavy metal used worldwide in several applications, especially in industry. People exposed to lead can develop a wide range of symptoms associated with lead poisoning. Many effects of lead poisoning are reported in the literature, showing a compromising of whole body health, with symptoms related to cardiovascular, immune, bone, reproductive, hematological, renal, gastrointestinal, and nervous system. However, the molecular lead targets as well as the pathways affected by lead poisoning are not completely described...
February 12, 2018: Critical Reviews in Toxicology
https://www.readbyqxmd.com/read/29389244/pyrethroid-epidemiology-a-quality-based-review
#3
Carol J Burns, Timothy P Pastoor
Pyrethroids are commonly used around the home and in agricultural production to control insects. Human contact to one or more pyrethroid insecticides is likely. Numerous epidemiology studies have evaluated the association between health outcomes in humans and pyrethroid exposure. The purpose of this review was to identify and evaluate the quality of pyrethroid-related epidemiology studies that addressed chronic health effects, and compare findings with animal toxicology studies. We evaluated the quality of 61 studies published between 2000 and 2016 by using elements of outcome, exposure metric, exposure level, and study design...
February 1, 2018: Critical Reviews in Toxicology
https://www.readbyqxmd.com/read/29372646/correction-to-finley-et-al-evaluation-of-tremolite-asbestos-exposures-associated-with-the-use-of-commercial-products
#4
(no author information available yet)
No abstract text is available yet for this article.
January 26, 2018: Critical Reviews in Toxicology
https://www.readbyqxmd.com/read/29309204/toxicological-and-ecotoxicological-properties-of-gas-to-liquid-gtl-products-2-ecotoxicology
#5
Graham F Whale, James Dawick, Christopher B Hughes, Delina Lyon, Peter J Boogaard
Gas-to-liquid (GTL) products are synthetic hydrocarbons produced from natural gas using a catalytic process known as the Fischer-Tropsch process. This process yields a synthetic crude oil that consists of saturated hydrocarbons which can subsequently be refined to a range of products analogous to those obtained from petroleum refining. However, in contrast to their petroleum-derived analogs, GTL products are essentially free of unsaturated or aromatic compounds and do not contain any sulfur-, oxygen-, or nitrogen-containing compounds...
January 8, 2018: Critical Reviews in Toxicology
https://www.readbyqxmd.com/read/29243948/shanghai-health-study-2001-2009-what-was-learned-about-benzene-health-effects
#6
Sherilyn A Gross, Dennis J Paustenbach
The Shanghai Health Study (SHS) was a large epidemiology study conducted as a joint effort between the University of Colorado and Fudan University in Shanghai, China. The study was funded by members of the American Petroleum Institute between 2001 and 2009 and was designed to evaluate the human health effects associated with benzene exposure. Two arms of the SHS included: an occupational-based molecular epidemiology study and several hospital-based case control studies. Consistent with historical literature, following sufficient exposure to relatively high airborne concentrations and years of exposure, the SHS concluded that exposure to benzene resulted in an increased risk of various blood and bone marrow abnormalities such as benzene poisoning, aplastic anemia (AA), myelodysplastic syndrome (MDS), and acute myeloid leukemia (AML)...
December 15, 2017: Critical Reviews in Toxicology
https://www.readbyqxmd.com/read/29239234/adoption-of-in-vitro-systems-and-zebrafish-embryos-as-alternative-models-for-reducing-rodent-use-in-assessments-of-immunological-and-oxidative-stress-responses-to-nanomaterials
#7
Helinor J Johnston, Rachel Verdon, Suzanne Gillies, David M Brown, Teresa F Fernandes, Theodore B Henry, Adriano G Rossi, Lang Tran, Carl Tucker, Charles R Tyler, Vicki Stone
Assessing the safety of engineered nanomaterials (NMs) is paramount to the responsible and sustainable development of nanotechnology, which provides huge societal benefits. Currently, there is no evidence that engineered NMs cause detrimental health effects in humans. However, investigation of NM toxicity using in vivo, in vitro, in chemico, and in silico models has demonstrated that some NMs stimulate oxidative stress and inflammation, which may lead to adverse health effects. Accordingly, investigation of these responses currently dominates NM safety assessments...
December 14, 2017: Critical Reviews in Toxicology
https://www.readbyqxmd.com/read/29171327/a-review-of-the-evidence-for-endocrine-disrupting-effects-of-current-use-chemicals-on-wildlife-populations
#8
Peter Matthiessen, James R Wheeler, Lennart Weltje
This review critically examines the data on claimed endocrine-mediated adverse effects of chemicals on wildlife populations. It focuses on the effects of current-use chemicals, and compares their apparent scale and severity with those of legacy chemicals which have been withdrawn from sale or use, although they may still be present in the environment. The review concludes that the effects on wildlife of many legacy chemicals with endocrine activity are generally greater than those caused by current-use chemicals, with the exception of ethinylestradiol and other estrogens found in sewage effluents, which are causing widespread effects on fish populations...
November 24, 2017: Critical Reviews in Toxicology
https://www.readbyqxmd.com/read/29130357/biological-effects-of-metal-degradation-in-hip-arthroplasties
#9
Donatella Granchi, Lucia Maria Savarino, Gabriela Ciapetti, Nicola Baldini
Metals and metal alloys are the most used materials in orthopedic implants. The focus is on total hip arthroplasty (THA) that, though well tolerated, may be associated with local and remote adverse effects in the medium-long term. This review aims to summarize data on the biological consequences of the metal implant degradation that have been attributed predominantly to metal-on-metal (MoM) THA. Local responses to metals consist of a broad clinical spectrum ranging from small asymptomatic tissue lesions to severe destruction of bone and soft tissues, which are designated as metallosis, adverse reactions to metal debris (ARMD), aseptic lymphocytic vasculitis associated lesion (ALVAL), and pseudotumors...
November 13, 2017: Critical Reviews in Toxicology
https://www.readbyqxmd.com/read/29095661/evaluating-the-evidence-on-genotoxicity-and-reproductive-toxicity-of-carbon-black-a-critical-review
#10
Ishrat Chaudhuri, Claudia Fruijtier-Pölloth, Yufanyi Ngiewih, Len Levy
Carbon black is produced industrially by the partial combustion or thermal decomposition of gaseous or liquid hydrocarbons under controlled conditions. It is considered a poorly soluble, low toxicity (PSLT) particle. Recently, results from a number of published studies have suggested that carbon black may be directly genotoxic, and that it may also cause reproductive toxicity. Here, we review the evidence from these studies to determine whether carbon black is likely to act as a primary genotoxicant or reproductive toxicant in humans...
November 2, 2017: Critical Reviews in Toxicology
https://www.readbyqxmd.com/read/29095660/assessing-cancer-hazards-of-bitumen-emissions-a-case-study-for-complex-petroleum-substances
#11
Anthony J Kriech, Ceinwen A Schreiner, Linda V Osborn, Anthony J Riley
When assessing cancer hazard and risk associated with a complex petroleum substance, like bitumen emissions, there are often conflicting results related to human, animal and mechanistic studies. Validation of the complex composition to assure that it matches real-world exposures and control of confounders are pivotal factors in study design to allow the necessary read-across during assessments. Several key studies on bitumen emissions in two-year dermal cancer assays reported variable outcomes ranging from high cancer incidence to no cancer incidence...
November 2, 2017: Critical Reviews in Toxicology
https://www.readbyqxmd.com/read/29256739/erratum
#12
(no author information available yet)
No abstract text is available yet for this article.
November 2017: Critical Reviews in Toxicology
https://www.readbyqxmd.com/read/29035126/re-byber-et%C3%A2-al-in-critical-reviews-in-toxicology-2016-46-191-240
#13
Carl-Gustaf Elinder, Gunnar F Nordberg
No abstract text is available yet for this article.
October 16, 2017: Critical Reviews in Toxicology
https://www.readbyqxmd.com/read/29035119/response-to-letter-to-the-editor-from-elinder-and-nordberg-concerning-byber-et%C3%A2-al-2016-cadmium-or-cadmium-compounds-and-chronic-kidney-disease-in-workers-and-the-general-population-a-systematic-review-crit-rev-toxicol-46-3-191-240-doi-0-3109-10408444-2015
#14
Katarzyna Byber, Dominique Lison, Violaine Verougstraete, Holger Dressel, Philipp Hotz
No abstract text is available yet for this article.
October 16, 2017: Critical Reviews in Toxicology
https://www.readbyqxmd.com/read/29256698/erratum
#15
(no author information available yet)
No abstract text is available yet for this article.
October 2017: Critical Reviews in Toxicology
https://www.readbyqxmd.com/read/28885868/evaluating-the-moa-human-relevance-framework-for-f-344-rat-liver-epithelioid-granulomas-with-mineral-oil-hydrocarbons
#16
REVIEW
David Adenuga, Katy Goyak, R Jeffrey Lewis
Toxicology feeding studies of mineral oil hydrocarbons (MOHs), within the carbon number range C22-C28, results in species-specific epithelioid granulomas in the liver of F-344 rats but not in other rat strains, or species. While MOH has been detected, and some pathological effects have been shown to occur in other organs/tissues of F-344 rats and other rat strains/species, it is generally accepted that the effect of toxicological concern is species-specific inflammatory liver granuloma. As oil retention and other MOH-related nontoxic pathological changes in the liver are observed in humans, some have hypothesized that the potential for oil accumulation over a lifetime, through dietary sources, may predispose humans to similar liver effects as observed in F-344 rats...
October 2017: Critical Reviews in Toxicology
https://www.readbyqxmd.com/read/28681680/evolution-of-chemical-specific-adjustment-factors-csaf-based-on-recent-international-experience-increasing-utility-and-facilitating-regulatory-acceptance
#17
REVIEW
Virunya S Bhat, M E Bette Meek, Mathieu Valcke, Caroline English, Alan Boobis, Richard Brown
The application of chemical-specific toxicokinetic or toxicodynamic data to address interspecies differences and human variability in the quantification of hazard has potential to reduce uncertainty and better characterize variability compared with the use of traditional default or categorically-based uncertainty factors. The present review summarizes the state-of-the-science since the introduction of the World Health Organization/International Programme on Chemical Safety (WHO/IPCS) guidance on chemical-specific adjustment factors (CSAF) in 2005 and the availability of recent applicable guidance including the WHO/IPCS guidance on physiologically-based pharmacokinetic (PBPK) modeling in 2010 as well as the U...
October 2017: Critical Reviews in Toxicology
https://www.readbyqxmd.com/read/28661217/a-comprehensive-framework-for-evaluating-the-environmental-health-and-safety-implications-of-engineered-nanomaterials
#18
REVIEW
William K Boyes, Brittany Lila M Thornton, Souhail R Al-Abed, Christian P Andersen, Dermont C Bouchard, Robert M Burgess, Elaine A Cohen Hubal, Kay T Ho, Michael F Hughes, Kirk Kitchin, Jay R Reichman, Kim R Rogers, Jeffrey A Ross, Paul T Rygiewicz, Kirk G Scheckel, Sheau-Fung Thai, Richard G Zepp, Robert M Zucker
Engineered nanomaterials (ENM) are a growing aspect of the global economy, and their safe and sustainable development, use, and eventual disposal requires the capability to forecast and avoid potential problems. This review provides a framework to evaluate the health and safety implications of ENM releases into the environment, including purposeful releases such as for antimicrobial sprays or nano-enabled pesticides, and inadvertent releases as a consequence of other intended applications. Considerations encompass product life cycles, environmental media, exposed populations, and possible adverse outcomes...
October 2017: Critical Reviews in Toxicology
https://www.readbyqxmd.com/read/28937307/weight-of-evidence-analysis-for-assessing-the-genotoxic-potential-of-carbon-nanotubes
#19
Peter Møller, Nicklas Raun Jacobsen
Carbon nanotube (CNT) is a nanomaterial that has received interest because of its high-tensile strength and low weight. Although CNTs differ substantially in physico-chemical properties, they share high aspect ratio which resembles that of asbestos and other fibers causing lung cancer and mesothelioma. One type of multi-walled CNTs (i.e. MWCNT-7) has been classified as possibly carcinogenic to humans by IARC (Group 2B) based on experimental animal data, whereas other types of MWCNTs and single-walled CNTs (SWCNT) could not be classified due to lack of data from epidemiologic studies and insufficient mechanistic evidence...
September 22, 2017: Critical Reviews in Toxicology
https://www.readbyqxmd.com/read/28929839/capturing-ecology-in-modeling-approaches-applied-to-environmental-risk-assessment-of-endocrine-active-chemicals-in-fish
#20
Kate S Mintram, A Ross Brown, Samuel K Maynard, Pernille Thorbek, Charles R Tyler
Endocrine active chemicals (EACs) are widespread in freshwater environments and both laboratory and field based studies have shown reproductive effects in fish at environmentally relevant exposures. Environmental risk assessment (ERA) seeks to protect wildlife populations and prospective assessments rely on extrapolation from individual-level effects established for laboratory fish species to populations of wild fish using arbitrary safety factors. Population susceptibility to chemical effects, however, depends on exposure risk, physiological susceptibility, and population resilience, each of which can differ widely between fish species...
September 20, 2017: Critical Reviews in Toxicology
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