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Journal of Neuroendocrinology

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https://www.readbyqxmd.com/read/29224246/circadian-peak-dopaminergic-activity-response-at-the-biological-clock-pacemaker-suprachiasmatic-nucleus-area-mediates-the-metabolic-responsiveness-to-a-high-fat-diet
#1
Shuqin Luo, Yahong Zhang, Michael Ezrokhi, Yang Li, Tsung-Huang Tsai, Anthony H Cincotta
Among vertebrate species of the major vertebrate classes in the wild, a seasonal rhythm of whole body fuel metabolism, oscillating from lean to obese condition, is a common biological phenomenon. This annual cycle is driven in part by annual changes in the circadian dopaminergic signaling at the suprachiasmatic nuclei (SCN), with diminution of circadian peak dopaminergic activity at the SCN facilitating development of the seasonal obese insulin resistant condition. The present study investigated whether such an ancient circadian dopamine-SCN activity system for expression of the seasonal obese, insulin resistant phenotype may be operative in animals made obese, insulin resistant by high fat feeding and if so whether reinstatement of the circadian dopaminergic peak at the SCN would be sufficient to reverse the adverse metabolic impact of the high fat diet without alteration of caloric intake...
December 10, 2017: Journal of Neuroendocrinology
https://www.readbyqxmd.com/read/29222949/a-switch-from-gaba-inhibition-to-excitation-of-vasopressin-neurons-exacerbates-the-development-angiotensin-ii-dependent-hypertension
#2
Aaron K Korpal, Su Young Han, Daryl O Schwenke, Colin H Brown
Hypothalamic magnocellular neurons secrete vasopressin into the systemic circulation to maintain blood pressure by increasing renal water reabsorption and by vasoconstriction. When blood pressure rises, baroreflex activation normally inhibits vasopressin neurons via activation of GABAergic inputs. However, plasma vasopressin levels are paradoxically elevated in several models of hypertension and in some patients with essential hypertension, despite increased blood pressure. We have previously shown that vasopressin neuron activity is increased early in the development of moderate angiotensin II-dependent hypertension via blunted baroreflex inhibition of vasopressin neurons...
December 9, 2017: Journal of Neuroendocrinology
https://www.readbyqxmd.com/read/29211317/neurobiology-of-gender-identity-and-sexual-orientation
#3
REVIEW
Charles E Roselli
Sexual identity and sexual orientation are independent components of a person's sexual identity. These dimensions are most often in harmony with each other and with an individual's genital sex, but not always. This review discusses the relationship of sexual identity and sexual orientation to prenatal factors that act to shape the development of the brain and the expression of sexual behaviors in animals and humans. One major influence discussed relates to organizational effects that the early hormone environment exerts on both gender identity and sexual orientation...
December 6, 2017: Journal of Neuroendocrinology
https://www.readbyqxmd.com/read/29194818/rapid-non-genomic-modulation-by-neurosteroids-of-dendritic-spines-in-the-hippocampus-androgen-estrogen-and-corticosteroid
#4
REVIEW
Gen Murakami, Yasushi Hojo, Asami Kato, Yoshimasa Komatsuzaki, Shigeo Horie, Mika Soma, Jonghyuk Kim, Suguru Kawato
Memories are stored in synapses which consist of axon terminals and dendritic spines. Dendritic spines are postsynaptic structures of synapses and essential for synaptic plasticity and cognition. Therefore, extensive investigations about functions and structures of spines have been performed. Sex steroids and stress steroids have been shown to modulate hippocampal synapses. Although rapid modulatory action of sex steroids on synapses has been studied in hippocampal neurons over several decades, its essential molecular mechanisms have not been fully understood...
December 1, 2017: Journal of Neuroendocrinology
https://www.readbyqxmd.com/read/29194815/the-new-pan-american-neuroendocrine-society
#5
EDITORIAL
Roger Guillemin
The new Pan-American Neuroendocrine Society already has an official journal, which of course is the Journal of Neuroendocrinology (JNE). This journal has been the primary presenter of the remarkable expansion of this field since 1989 - documenting its long history and ongoing development. The word Neuro-Endocrinologie, with the hyphen, first appeared in French in 1946 as the title of the enormous (1086 pages) book by Roussy and Mosinger (1). This article is protected by copyright. All rights reserved.
December 1, 2017: Journal of Neuroendocrinology
https://www.readbyqxmd.com/read/29178496/kisspeptin-gnrh-and-er%C3%AE-colocalise-with-nnos-neurones-in-prepubertal-female-sheep
#6
Michelle N Bedenbaugh, Ryan C O'Connell, Justin A Lopez, Richard B McCosh, Robert L Goodman, Stanley M Hileman
Puberty is a process which integrates multiple inputs that ultimately cause an increase in gonadotrophin-releasing hormone (GnRH) secretion. While kisspeptin neurones play an integral role in GnRH secretion and puberty onset, other systems are also likely important. One potential component is nitric oxide (NO), a gaseous neurotransmitter synthesized by nitric oxide synthase (NOS). In this study, we sought to neuroanatomically characterise neuronal NOS (nNOS) in prepubertal female sheep and determine if oestradiol would exert effects on this system...
November 25, 2017: Journal of Neuroendocrinology
https://www.readbyqxmd.com/read/29151262/the-founding-fathers-of-the-international-neuroendocrine-society-ins
#7
EDITORIAL
Víctor D Ramirez
It seems appropriate in this Special Issue of Journal of Neuroendocrinology, which marks the new Pan American Neuroendocrine Society (PANS), to recognize the first group of international scientists who were linked by their common purpose to promote neuroendocrinology throughout the world. This article is protected by copyright. All rights reserved.
November 19, 2017: Journal of Neuroendocrinology
https://www.readbyqxmd.com/read/29150901/expression-of-the-clock-gene-rev-erb%C3%AE-in-the-brain-controls-the-circadian-organization-of-food-intake-and-locomotor-activity-but-not-daily-variations-of-energy-metabolism
#8
Satish Sen, Stéphanie Dumont, Dominique Sage-Ciocca, Sophie Reibel, Paul de Goede, Andries Kalsbeek, Etienne Challet
The nuclear receptor REV-ERBα is part of the molecular clock mechanism and thought to be involved in a variety of biological processes within metabolically active peripheral tissues as well. To investigate whether Rev-erbα (also known as Nr1d1) in the brain plays a role in the daily variations of energy metabolism, feeding behaviour and the sleep-wake cycle, we studied mice with global (GKO) or brain (BKO) deletion of Rev-erbα. Mice were studied both in a light-dark cycle and constant darkness, and 24-h variations of Respiratory quotient (RQ) and energy expenditure, as well as the temporal patterns of rest-activity and feeding behavior were recorded...
November 18, 2017: Journal of Neuroendocrinology
https://www.readbyqxmd.com/read/29121420/obesity-during-pregnancy-in-the-mouse-alters-the-netrin-1-responsiveness-of-fetal-arcuate-nucleus-npy-neurons
#9
Tessa R Sanders, Kelly A Glendining, Christine L Jasoni
When individuals undergo gestation in an obese dam, they are at increased risk for impairments in the brain's ability to regulate body weight. In rodents, gestation in an obese dam leads to a number of changes to the development of the hypothalamic neurons that regulate body weight, including reduced neuronal connectivity at birth. Here, we sought to gain a clearer picture of how this neural circuitry develops normally, and to explore the mechanism underpinning the deficiency in connectivity seen in fetuses developing in obese dams...
November 9, 2017: Journal of Neuroendocrinology
https://www.readbyqxmd.com/read/29121414/stress-induced-suppression-of-neuropeptide-y-induced-hunger-in-anorexic-chicks-involves-corticotropin-releasing-factor-signaling-and-the-paraventricular-nucleus-of-the-hypothalamus
#10
Jinxin Wang, Jiaqing Yi, Paul B Siegel, Mark A Cline, Elizabeth R Gilbert
The Virginia lines of chickens have been selected for low (LWS) or high (HWS) juvenile body weight and have different severities of anorexia and obesity, respectively. The LWS that are exposed to stressors at hatch are refractory to neuropeptide Y (NPY)-induced food intake and the objective was to elucidate the underlying mechanisms. Chicks were exposed to a stressor (-20°C for 6 minutes, and 22°C and delayed access to food for 24 hours) after hatch and hypothalamic nuclei, including the lateral hypothalamus (LH), paraventricular nucleus (PVN), ventromedial hypothalamus (VMH), and arcuate nucleus (ARC), were collected 5 days later...
November 9, 2017: Journal of Neuroendocrinology
https://www.readbyqxmd.com/read/29117457/diurnal-and-photoperiodic-changes-in-thyrotrophin-stimulating-hormone-%C3%AE-tsh%C3%AE-expression-and-associated-regulation-of-deiodinase-enzymes-dio2-dio3-in-the-female-juvenile-chicken-hypothalamus
#11
I C Dunn, P W Wilson, Y Shi, D W Burt, A S I Loudon, P J Sharp
Increased TSHβ expression in the pars tuberalis is thought to be an early step in the neuroendocrine mechanism transducing photoperiodic information. This study aimed to determine the relationship between long-photoperiods (LP) and diurnal TSHβ gene expression in the juvenile chicken by comparing LP-photostimulated birds with groups kept on short photoperiods (SP) for 1 or 12 days. TSHβ expression increased 3 and 23-fold after 1 and 12 days LP-photostimulation both during the day and at night. In both SP and LP conditions, TSHβ expression was between 3 and 14-fold higher at night than in the day, suggesting that TSHβ expression cycles in a diurnal pattern irrespective of photoperiod...
November 8, 2017: Journal of Neuroendocrinology
https://www.readbyqxmd.com/read/29072794/effects-of-gaba-active-steroids-in-the-female-brain-with-focus-on-the-premenstrual-dysphoric-disorder
#12
REVIEW
Marie Bixo, Maja Johansson, Erika Timby, Louise Michalski, Torbjörn Bäckström
PMDD (premenstrual dysphoric disorder) afflicts 3-5% of women of childbearing age, and is characterized by recurrent negative mood symptoms, e.g. irritability, depression, anxiety and emotional lability during the luteal phase of the menstrual cycle. The etiology of PMDD is unknown, but a temporal association with circulating ovarian steroids, in particular progesterone and its metabolite allopregnanolone, during the luteal phase has been established. Allopregnanolone is a positive modulator of the GABAA receptor: it is sedative in high concentrations, but may precipitate paradoxical adverse effects on mood at levels corresponding to luteal phase concentrations in susceptible women...
October 26, 2017: Journal of Neuroendocrinology
https://www.readbyqxmd.com/read/29063642/neonatal-maternal-separation-opposes-the-facilitatory-effect-of-castration-on-the-respiratory-response-to-hypercapnia-of-the-adult-male-rat-evidence-for-the-involvement-of-the-medial-amygdala
#13
Luana Tenorio-Lopes, Mathilde S Henry, Danuzia Marques, Marie-Ève Tremblay, Guy Drolet, Frederic Bretzner, Richard Kinkead
Respiratory manifestations of panic disorder (PD) include a greater respiratory instability and enhanced responsiveness to CO2 compared to normal individuals. While the prevalence of PD is ~3 times greater in women compared with men, the origins of this sexual dimorphism remain poorly understood. Much like PD patients, adult female rats previously subjected to neonatal maternal separation (NMS) show an increase in their ventilatory response to CO2 . Because this effect of NMS is not observed in males, we hypothesized that testosterone prevents NMS-induced hyper-responsiveness to CO2 ...
October 24, 2017: Journal of Neuroendocrinology
https://www.readbyqxmd.com/read/29044801/differential-physiological-responses-to-central-leptin-overexpression-in-male-and-female-rats
#14
Isabelle Côté, Sara M Green, Hale Z Toklu, Drake Morgan, Christy S Carter, Nihal Tümer, Philip J Scarpace
Brains of females are more sensitive to the acute catabolic actions of leptin. However, sex differences in the long-term physiological responses to central leptin receptor modulation are unknown. To this end, we centrally delivered a viral vector to overexpress leptin (Leptin), a neutral leptin receptor antagonist (Leptin-Antagonist), or a green fluorescence protein (Control). We examined chronic changes in body weight and composition in male and female rats. Females displayed greater and sustained responses to Leptin whereas males rapidly lost physiological effects and developed leptin resistance confirmed by lower acute leptin-mediated phosphorylation of STAT3 (P-STAT3)...
October 17, 2017: Journal of Neuroendocrinology
https://www.readbyqxmd.com/read/29044774/3d-distribution-of-tyrosine-hydroxylase-vasopressin-and-oxytocin-neurons-in-the-transparent-postnatal-mouse-brain
#15
David Godefroy, Chloé Dominici, Hélène Hardin-Pouzet, Youssef Anouar, Stéphane Melik-Parsadaniantz, William Rostene, Annabelle Reaux-Le Goazigo
Over the years, advances in immunohistochemistry techniques have been a critical step in detecting and mapping neuromodulatory substances in the central nervous system. The better quality and specificity of primary antibodies, new staining procedures and the spectacular development of imaging technologies have allowed such progress. Very recently, new methods permitting tissue transparency have been successfully used on brain tissues. In this work, we combined whole-mount immunostaining for tyrosine hydroxylase (TH), oxytocin (OXT) and arginine vasopressin (AVP), with iDISCO+ clearing method, light-sheet microscopy and semi automated counting of 3D-labelled neurons to obtain a 3D distribution of these neuronal populations in a 5-day postnatal (P5) mouse brain...
October 16, 2017: Journal of Neuroendocrinology
https://www.readbyqxmd.com/read/29024187/diversity-of-oxytocin-neurons-beyond-magno-and-parvocellular-cell-types
#16
REVIEW
Ferdinand Althammer, Valery Grinevich
The hypothalamic neuropeptide oxytocin (OT), which is evolutionarily conserved among different species throughout the animal kingdom, is a key modulator of a variety of socio-emotional behaviors such as fear, trust and empathy. OT cells in the mammalian hypothalamus have been traditionally divided into two distinct types - magnocellular (magnOT) and parvocellular (parvOT) or preautonomic neurons. This distinction is based on OT cell sizes and shapes, projections, electrophysiological activity and functions...
October 12, 2017: Journal of Neuroendocrinology
https://www.readbyqxmd.com/read/29024170/steroids-stress-and-the-gut-microbiome-brain-axis
#17
REVIEW
Marc J Tetel, Geert J de Vries, Roberto C Melcangi, GianCarlo Panzica, Siobhain M O'Mahony
It is becoming well established that the gut microbiome has a profound impact on human health and disease. In this review, we explore how steroids can influence the gut microbiota, and in turn how the gut microbiota can influence hormone levels. Within the context of the gut microbiome-brain axis, we discuss how perturbations in the gut microbiota can alter the stress axis and behavior. In addition, human studies on the possible role of gut microbiota in depression and anxiety are examined. Finally, we present some of the challenges and important questions that need to be addressed by future research in this exciting new area at the intersection of steroids, stress, gut-brain axis and human health...
October 12, 2017: Journal of Neuroendocrinology
https://www.readbyqxmd.com/read/29024164/understanding-role-of-steroids-in-typical-and-atypical-brain-development-advantages-of-using-a-brain-in-a-dish-approach
#18
REVIEW
Dwaipayan Adhya, Emily Annuario, Madeline A Lancaster, Jack Price, Simon Baron-Cohen, Deepak P Srivastava
Steroids have an important role in growth, development, sexual differentiation and reproduction. All four classes of steroids, androgens, estrogens, progestogens and glucocorticoids, have varying effects on the brain. Androgens and estrogens are involved in the sexual differentiation of the brain, and also influence cognition. Progestogens such as progesterone and its metabolites have been shown to be involved in neuroprotection, although their protective effects are timing dependent. Glucocorticoids are linked with stress and memory performance, also in a dose- and time-dependent manner...
October 12, 2017: Journal of Neuroendocrinology
https://www.readbyqxmd.com/read/29024132/expression-of-isotocin-is-male-specifically-upregulated-by-gonadal-androgen-in-the-medaka-brain
#19
Junpei Yamashita, Yukika Kawabata, Kataaki Okubo
Oxytocin, a mammalian neuropeptide primarily synthesized in the supraoptic and paraventricular nuclei of the hypothalamus, mediates a variety of physiological and behavioral processes ranging from parturition and lactation to affiliation and prosociality. Multiple studies in rodents have shown that the expression of the oxytocin gene (Oxt) is stimulated by estrogen, while androgen has no apparent effect. However, this finding is not consistent across all studies, and no study has examined sex steroid regulation of Oxt or its orthologs in other animals...
October 10, 2017: Journal of Neuroendocrinology
https://www.readbyqxmd.com/read/29024113/stress-related-cortisol-responsivity-modulates-prospective-memory
#20
Katharina Glienke, Martina Piefke
It is known that there is interindividual variation in behavioral and physiological stress reactions to the same stressor. The present study aimed at examining the impact of cortisol responsivity on performance in a complex real life-like prospective memory (PM) paradigm by a reanalysis of data published previously with the focus on the taxonomy of cognitive dimensions of PM. 21 male subjects were stressed with the Socially Evaluated Cold Pressor Test (SECPT) before the planning of intentions. Another group of 20 males underwent a control procedure...
October 10, 2017: Journal of Neuroendocrinology
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