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Journal of Neuroendocrinology

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https://www.readbyqxmd.com/read/29427522/glucosensing-capacity-of-rainbow-trout-telencephalon
#1
Cristina Otero-Rodiño, Ana Rocha, Rosa Álvarez-Otero, Rosa M Ceinos, Marcos A López-Patiño, Jesús M Míguez, José Miguel Cerdá-Reverter, José L Soengas
To assess the hypothesis of glucosensing systems present in fish telencephalon, we first demonstrated in rainbow trout by in situ hybridization the presence of glucokinase (GK). Then, we assessed the response of glucosensing markers in rainbow trout telencephalon 6h after ICV treatment with glucose or 2-deoxyglucose (inducing glucoprivation). We evaluated the response of parameters related to the mechanisms dependent on GK, liver X receptor (LXR), mitochondrial activity, sweet taste receptor, and sodium-glucose linked transporter 1 (SGLT-1)...
February 10, 2018: Journal of Neuroendocrinology
https://www.readbyqxmd.com/read/29424020/activation-patterns-of-vasopressinergic-and-oxytocinergic-brain-regions-following-social-play-exposure-in-juvenile-male-and-female-rats
#2
C J Reppucci, C K Gergely, A H Veenema
Social play is a highly rewarding and motivated behavior predominately displayed by juveniles and expressed by nearly all mammalian species. Prior work suggested that the vasopressin (AVP) and oxytocin (OT) systems can regulate the expression of social play in sex-specific ways. Here we investigated whether there are sex differences in the recruitment of vasopressinergic and oxytocinergic brain regions following social play exposure in juvenile rats. Single-housed rats were allowed to play, in their home cage, with an age- and sex-matched unfamiliar conspecific for 10 min, or received similar handling but no partner...
February 9, 2018: Journal of Neuroendocrinology
https://www.readbyqxmd.com/read/29423924/timing-of-prenatal-exposure-to-trauma-and-altered-placental-expressions-of-hpa-axis-genes-and-genes-driving-neurodevelopment
#3
Wei Zhang, Li Qian, Maya Deyssenroth, Luca Lambertini, Jackie Finik, Jacob Ham, Yongling Huang, Kenji J Tsuchiya, Patricia Pehme, Jessica Buthmann, Sachiko Yoshida, Jia Chen, Yoko Nomura
Prenatal maternal stress increases the risk for negative developmental outcomes in offspring, however the underlying biological mechanisms remain largely unexplored. In this study, alterations in placental gene expression associated with maternal stress were examined to elucidate potential underlying epi/genetic mechanisms. Expression levels of 40 selected genes involved in regulating fetal HPA-axis and neurodevelopment were profiled in placental tissues collected from a birth cohort established around the time of Superstorm Sandy...
February 9, 2018: Journal of Neuroendocrinology
https://www.readbyqxmd.com/read/29418022/acute-antiobesity-effects-of-intracerebroventricular-11%C3%AE-hsd1-inhibitor-administration-in-diet-induced-obese-mice
#4
Minchul Seo, S K M Azizul Islam, Seong-Su Moon
Hypothalamus is the regulatory center of both appetite and energy balance, and endoplasmic reticulum (ER) stress in the hypothalamus is involved in the pathogenesis of obesity. Recently, inhibition of 11 β hydroxysteroid dehydrogenase type1 (11β-HSD1) was reported to have an anti-obesity effect by reducing fat mass. However, link between the role of 11β-HSD1 in hypothalamus and obesity has yet to be elucidated. In this study, embryonal primary hypothalamic neurons and high fat diet (HFD) fed mice were used to investigate the anorexigenic effects of 11β-HSD1 inhibitors in in vitro and in vivo...
February 8, 2018: Journal of Neuroendocrinology
https://www.readbyqxmd.com/read/29411916/neural-androgen-receptors-affect-the-number-of-surviving-new-neurons-in-the-adult-dentate-gyrus-of-male-mice
#5
Ashlyn Swift-Gallant, Paula Duarte-Guterman, Dwayne K Hamson, Muna Ibrahim, D Ashley Monks, Liisa A M Galea
Adult hippocampal neurogenesis occurs in many mammalian species. In rats, the survival of new neurons within the hippocampus is modulated by androgen action via the androgen receptor (AR), however it is not known whether this holds true in mice. Furthermore, evidence is mixed as to whether androgens act in neural tissue or via peripheral non-neural targets to promote hippocampal neuron survival. We evaluated whether androgen action via AR underlies the survival of new neurons in mice, and asked whether increasing AR selectively in neural tissue would increase new neuron survival in the hippocampus...
February 7, 2018: Journal of Neuroendocrinology
https://www.readbyqxmd.com/read/29411913/a-novel-role-of-the-corticotropin-releasing-hormone-crh-regulating-peptide-teneurin-1-c-terminal-associated-peptide-tcap-1-on-glucose-uptake-into-the-brain
#6
David W Hogg, Yani Chen, Andrea L D'Aquila, Mei Xu, Mia Husic, Laura A Tan, Chris Bull, David A Lovejoy
Teneurin C-terminal associated peptide (TCAP) is an ancient paracrine signaling agent that evolved via lateral gene transfer from prokaryotes into an early metazoan ancestor. Although it bears structural similarity to corticotropin-releasing hormone (CRH), it inhibits the in vivo actions of CRH. The TCAPs are highly expressed in neurons where they induce rapid cytoskeletal rearrangement and are neuroprotective. Because these processes are highly energy dependent, this suggests that TCAP has the potential to regulate glucose uptake as glucose is the primary energy substrate in brain, and neurons require a steady supply to meet the high metabolic demands of neuronal communication...
February 7, 2018: Journal of Neuroendocrinology
https://www.readbyqxmd.com/read/29405459/activation-of-organum-vasculosum-neurons-and-water-intake-in-mice-by-vasopressin-neurons-in-the-suprachiasmatic-nucleus
#7
REVIEW
Claire Gizowski, Cristian Zaelzer, Charles W Bourque
Previous studies have shown that mice housed under 12:12 h light-dark conditions display a pronounced increase in water intake during a 2-hour anticipatory period (AP) near the end of their active period (Zeitgeber Time ZT; ZT21.5-ZT23.5) compared to the preceding basal period (BP, ZT19.5-ZT21.5). This increased water intake during the AP is not associated with physiological stimuli for thirst, such as food intake, hyperosmolality, hyperthermia, or hypovolemia. Denying mice the water intake supplement during the AP causes them to be dehydrated at wake time...
February 5, 2018: Journal of Neuroendocrinology
https://www.readbyqxmd.com/read/29385631/editorial-new-perspectives-for-the-action-of-steroids-in-the-brain
#8
EDITORIAL
G C Panzica, R C Melcangi
The present Special Issue is a collection of some of the lectures presented at the 9th International Meeting on Steroids and the Nervous System, held in February 2017. These reviews provide an update on the state of the art of recent discoveries in three main fields of current research on the role of neuroactive steroids in the brain, with special emphasis on brain development and sexual differentiation, the cellular and molecular mechanisms involved in the action of neuroactive steroids, and clinical implications for the understanding of brain disease and for the potential therapeutic use of these molecules or their analogues...
January 31, 2018: Journal of Neuroendocrinology
https://www.readbyqxmd.com/read/29377458/maternal-thyroid-hormone-is-required-for-parvalbumin-neuron-development-in-the-anterior-hypothalamic-area
#9
Lisbeth Harder, Susi Dudazy-Gralla, Helge Müller-Fielitz, Jens Hjerling Leffler, Björn Vennström, Heike Heuer, Jens Mittag
Thyroid hormone (TH) is crucial for brain development and function. This becomes most evident in untreated congenital hypothyroidism, leading to irreversible mental retardation. Likewise, maternal hypothyroxinemia, a lack of TH during pregnancy, is associated with neurological dysfunction in the offspring such as autism and reduced intellectual capacity. In the brain, TH acts mainly through TH receptor alpha 1 (TRα1). Consequently, mice heterozygous for a dominant-negative mutation in TRα1 display profound neuroanatomical abnormalities including deranged development of parvalbumin neurons...
January 29, 2018: Journal of Neuroendocrinology
https://www.readbyqxmd.com/read/29377390/metabotropic-glutamate-receptor-subtype-7-has-critical-roles-in-regulation-of-the-endocrine-system-and-social-behaviors
#10
Miwako Masugi-Tokita, Tetsuya Yoshida, Susumu Kageyama, Mitsuhiro Kawata, Akihiro Kawauchi
Metabotropic glutamate receptor subtype 7 (mGluR7) is one of the group III mGluRs, which are negatively coupled to adenylate cyclase via Gi/Go proteins and localized to presynaptic active zones of the mammalian central nervous system. We previously reported that mGluR7 is essential for intermale aggression and amygdala-dependent fear learning. To elucidate the role of mGluR7 in the neuroendocrine system, we performed biochemical analyses and found a significant reduction of testosterone levels in mGluR7 knockout (KO) mice...
January 29, 2018: Journal of Neuroendocrinology
https://www.readbyqxmd.com/read/29377365/neonatal-exposure-to-estradiol-increases-dopaminergic-transmission-in-nucleus-accumbens-and-morphine-induced-conditioned-place-preference-in-adult-female-rats
#11
Christian Bonansco, Jonathan Martínez-Pinto, Roxana A Silva, Victoria B Velásquez, Andrés Martorell, Mónica V Selva, Pedro Espinosa, Pablo R Moya, Gonzalo Cruz, María Estela Andrés, Ramón Sotomayor-Zárate
Steroid sex hormones produce physiological effects in reproductive tissues and also in non-reproductive tissues such as the brain, particularly in cortical, limbic and midbrain areas. Dopamine (DA) neurons involved in processes such as prolactin secretion (tuberoinfundibular system), motor circuit regulation (nigrostriatal system) and driving of motivated behavior (mesocorticolimbic system), are specially regulated by sex hormones. Indeed, sex hormones promote neurochemical and behavioral effects induced by drugs of abuse by tuning midbrain DA neurons in adult animals...
January 29, 2018: Journal of Neuroendocrinology
https://www.readbyqxmd.com/read/29356182/retinoic-acid-signalling-is-a-candidate-regulator-of-the-expression-of-pituitary-specific-transcription-factor-prop1-in-the-developing-rodent-pituitary
#12
Saishu Yoshida, Ken Fujiwara, Hiroto Nishihara, Takako Kato, Takashi Yashiro, Yukio Kato
Development of the anterior pituitary proceeds via spatiotemporal patterning of transcription factors and signalling molecules. Among them, retinoic acid (RA) functions as an important signalling molecule for vertebrate organogenesis in many tissues. However, little is known regarding target genes in the developing pituitary. The present study aimed to clarify the relationship between endogenous RA signalling and mRNA expression of the pituitary-specific transcription factor Prop1 in the pituitary primordium of Rathke's pouch...
January 22, 2018: Journal of Neuroendocrinology
https://www.readbyqxmd.com/read/29356147/kisspeptin-neurones-in-the-posterodorsal-medial-amygdala-modulate-sexual-partner-preference-and-anxiety-in-male-mice
#13
D A Adekunbi, X F Li, G Lass, K Shetty, O A Adegoke, S H Yeo, W H Colledge, S L Lightman, K T O'Byrne
The posterodorsal medial amygdala (MePD) is a neural site in the limbic brain involved in regulating emotional and sexual behaviours. There is however limited information on the specific neuronal cell type in the MePD functionally mediating these behaviours in rodents. The recent discovery of a significant kisspeptin neurone population in the MePD has raised interest in the possible role of kisspeptin and its cognate receptor in sexual behaviour. This study therefore tested the hypothesis that the MePD kisspeptin neurone population is involved in regulating attraction towards opposite sex conspecifics, sexual behaviour, social interaction and anxiety response by selectively stimulating these neurones using the novel pharmacosynthetic DREADDs (designer receptors exclusively activated by designer drugs) technique...
January 22, 2018: Journal of Neuroendocrinology
https://www.readbyqxmd.com/read/29345030/reproductive-status-dependent-kisspeptin-and-rfamide-related-peptide-rfrp-gene-expression-in-female-damaraland-mole-rats
#14
Cornelia Voigt, Nigel C Bennett
Damaraland mole rats (Fukomys damarensis) are cooperatively breeding, subterranean mammals, which exhibit high reproductive skew. Reproduction is monopolized by the dominant female of the group while subordinates are physiologically suppressed to the extent that they are anovulatory. It is thought that in these latter animals normal GnRH secretion from the hypothalamus is disrupted. The RFamide peptides kisspeptin (Kiss1) and RFamid-related peptide-3 (RFRP-3) are considered potent regulators of gonadotropin release...
January 18, 2018: Journal of Neuroendocrinology
https://www.readbyqxmd.com/read/29323764/integrative-neuro-humoral-regulation-of-oxytocin-neuron-activity-in-pregnancy-and-lactation
#15
REVIEW
Rachael A Augustine, Alexander J Seymour, Rebecca E Campbell, David R Grattan, Colin H Brown
Oxytocin is required for normal birth and lactation. Oxytocin is synthesised by hypothalamic supraoptic and paraventricular nuclei neurons and is released into the circulation from the posterior pituitary gland. Under basal conditions, circulating oxytocin levels are relatively constant but during birth and lactation, pulsatile oxytocin release triggers rhythmic contraction of the uterus during birth and milk ejection during suckling. Oxytocin levels are principally determined by the pattern of action potential firing that is, in turn, determined by the interplay between the intrinsic properties of the oxytocin neurons, regulation of their excitability by surrounding glia as well as by synaptic drive from their afferent inputs...
January 11, 2018: Journal of Neuroendocrinology
https://www.readbyqxmd.com/read/29265686/evidence-for-effective-structure-based-neuromodulatory-effects-of-new-analogs-of-neurosteroid-allopregnanolone
#16
Omar Taleb, Christine Patte-Mensah, Laurence Meyer, Véronique Kemmel, Philippe Geoffroy, Michel Miesch, Ayikoe-Guy Mensah-Nyagan
The neurosteroid allopregnanolone (AP) modulates neuroendocrine/neurobiological processes, including hypothalamic-pituitary-adrenocortical activities, pain, anxiety, neurogenesis and neuroprotection. These observations raised the hope to develop AP-based therapies against neuroendocrine and/or neurodegenerative disorders. However, the pleiotropic actions of AP, particularly its cell-proliferation-promoting effects, hamper the development of selective/targeted therapies. For example, while AP-induced neurogenesis may serve to compensate neuronal loss in degenerative brains, AP-evoked cell-proliferation is contraindicated for steroid-sensitive cancer patients...
December 19, 2017: Journal of Neuroendocrinology
https://www.readbyqxmd.com/read/29247563/acetylcholine-precursor-citicoline-cytidine-5-diphosphocholine-reduces-hypoglycemia-induced-neuronal-death-in-rats
#17
Jin Hee Kim, Bo Young Choi, A Ra Kho, Song Hee Lee, Jeong Hyun Jeong, Dae Ki Hong, Sang Hwon Lee, Min Sohn, Ohk Hyun Ryu, Moon-Gi Choi, Sang Won Suh
Citicoline (cytidine 5'-diphosphocholine) is an important precursor for the synthesis of neuronal plasma membrane phospholipids, mainly phosphatidylcholine. Administration of citicoline serves as a choline donor for the synthesis of acetylcholine. Citicoline has been shown to reduce the neuronal injury in animal models with cerebral ischemia and in clinical trials of stroke patients. Citicoline is currently being investigated in a multicenter clinical trial. However, citicoline has not yet been examined the context of hypoglycemia-induced neuronal death...
December 16, 2017: Journal of Neuroendocrinology
https://www.readbyqxmd.com/read/29247551/occipital-blood-brain-barrier-permeability-is-an-independent-predictor-of-visual-outcome-in-type-2-diabetics-irrespective-of-the-retinal-barrier-a-longitudinal-study
#18
Sulaiman I Abuhaiba, Miguel Cordeiro, Andre Amorim, Ângela Cruz, Bruno Quendera, Carlos Ferreira, Luisa Ribeiro, Rui Bernardes, Miguel Castelo-Branco
Blood brain barrier permeability in type 2 diabetic patients has been previously shown to be altered in certain brain regions such as the basal ganglia and the hippocampus. Because of the histological and functional similarities between the blood-brain-barrier (BBB) and the blood-retinal-barrier (BRB) we aimed to investigate how the permeability of both barriers predicts visual outcome. We included two control groups (Acute unilateral stroke patients n=9, and type 2 diabetics without BRB leakage n=10) and a case study group of type 2 diabetics with established BRB leakage (n=17)...
December 16, 2017: Journal of Neuroendocrinology
https://www.readbyqxmd.com/read/29237239/sex-steroid-hormones-and-brain-function-pet-imaging-as-a-tool-for-research
#19
REVIEW
R Moraga-Amaro, A van Waarde, J Doorduin, E F J de Vries
Sex steroid hormones are major regulators of sexual characteristic among species. These hormones, however, are also produced in the brain. Steroidal hormone-mediated signaling via the corresponding hormone receptors can influence brain function at a cellular level and thus affect behavior and higher brain functions. Altered steroid hormone signaling has been associated with psychiatric disorders, such as anxiety and depression. Neurosteroids are also thought to have a neuroprotective effect in neurodegenerative diseases So far, the role of steroid hormone receptors in physiological and pathological conditions have mainly been investigated post-mortem on animal or human brain tissues...
December 13, 2017: Journal of Neuroendocrinology
https://www.readbyqxmd.com/read/29224246/circadian-peak-dopaminergic-activity-response-at-the-biological-clock-pacemaker-suprachiasmatic-nucleus-area-mediates-the-metabolic-responsiveness-to-a-high-fat-diet
#20
Shuqin Luo, Yahong Zhang, Michael Ezrokhi, Yang Li, Tsung-Huang Tsai, Anthony H Cincotta
Among vertebrate species of the major vertebrate classes in the wild, a seasonal rhythm of whole body fuel metabolism, oscillating from lean to obese condition, is a common biological phenomenon. This annual cycle is driven in part by annual changes in the circadian dopaminergic signaling at the suprachiasmatic nuclei (SCN), with diminution of circadian peak dopaminergic activity at the SCN facilitating development of the seasonal obese insulin resistant condition. The present study investigated whether such an ancient circadian dopamine-SCN activity system for expression of the seasonal obese, insulin resistant phenotype may be operative in animals made obese, insulin resistant by high fat feeding and if so whether reinstatement of the circadian dopaminergic peak at the SCN would be sufficient to reverse the adverse metabolic impact of the high fat diet without alteration of caloric intake...
December 10, 2017: Journal of Neuroendocrinology
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