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American Journal of Reproductive Immunology: AJRI

Brandie D Taylor, Catherine L Haggerty, Roberta B Ness, David M Hougaard, Kristin Skogstrand, James M Roberts, Jørn Olsen
PROBLEM: A handful of studies report sexual dimorphism in the maternal angiogenic profile possibly influencing placental development and preeclampsia risk. This secondary analysis explored associations between fetal sex and soluble fms-like tyrosine kinase-1 (sFLT) and endoglin (9-35 weeks gestation) using data from a nested case-control study within the Danish National Birth Cohort. METHOD OF STUDY: A total of 448 preeclamptic women and 328 normotensive women had data on sFLT and endoglin...
August 14, 2018: American Journal of Reproductive Immunology: AJRI
Graciela Krikun
Initial studies on the chemokine stromal derived factor 1 (now referred to as CXCL12) were proposed to be enhanced in several diseases including those which affect the female reproductive tract. These include endometriosis, Asherman's syndrome, endometrial cancers, and ovarian cancers. Additionally, recent studies from our laboratory suggest that CXCL12 signaling is involved in leiomyomas (fibroids). These diseases present an inflammatory/hypoxic environment which further promotes pathology. At first, studies focused on signaling by CXCL12 via its well-known receptor, CXCR4...
August 14, 2018: American Journal of Reproductive Immunology: AJRI
Aneesha Varrey, Roberto Romero, Bogdan Panaitescu, Derek Miller, Tinnakorn Chaiworapongsa, Manasi Patwardhan, Jonathan Faro, Percy Pacora, Sonia S Hassan, Chaur-Dong Hsu, Nardhy Gomez-Lopez
PROBLEM: Human β-defensins (HBDs) are antimicrobial peptides that participate in the soluble innate immune mechanisms against infection. Herein, we determined whether HBD-1 was present in amniotic fluid during normal pregnancy and whether its concentrations change with intra-amniotic inflammation and/or infection. METHOD OF STUDY: Amniotic fluid was collected from 219 women in the following groups: (a) midtrimester who delivered at term (n = 35); (b) term with (n = 33) or without (n = 17) labor; (c) preterm labor with intact membranes who delivered at term (n = 29) or who delivered preterm with (n = 19) and without (n = 29) intra-amniotic inflammation and infection or with intra-amniotic inflammation but without infection (n = 21); and (d) preterm prelabor rupture of membranes (pPROM) with (n = 19) and without (n = 17) intra-amniotic inflammation/infection...
August 12, 2018: American Journal of Reproductive Immunology: AJRI
Manu Banadakoppa, Meena Balakrishnan, Chandra Yallampalli
PROBLEM: Antiangiogenic molecule soluble fms-like tyrosine kinase receptor 1 (sFLT1) released from trophoblast cells is associated with pregnancy-specific hypertensive disorder pre-eclampsia. Cause of elevated sFLT1 in pre-eclampsia patients is not well understood. Despite evidence of excess systemic and placental complement activation in pre-eclampsia patients, its role in pathophysiology is not clear. If the complement activation plays a role in upregulation and secretion of sFLT1 is not known...
August 12, 2018: American Journal of Reproductive Immunology: AJRI
Adrienn Lajko, Matyas Meggyes, Balazs Daniel Fulop, Noemi Gede, Dora Reglodi, Laszlo Szereday
PROBLEM: PACAP is a neuropeptide having a major relevance in the nervous system and in several peripheral organs including those of the reproductive system. PACAP-deficient mice have several morphological, biochemical, behavioral defects, and show reduced fertility. Female reproductive functions such as fertility, mating behavior, maternal behaviors, and implantation alterations have been widely investigated, but no comparative immune analyses are available in pregnant wild-type (WT) and PACAP knockout (KO) mice...
August 9, 2018: American Journal of Reproductive Immunology: AJRI
Lisa M Rogers, Anjali P Anders, Ryan S Doster, Elizabeth A Gill, Juan S Gnecco, Jacob M Holley, Tara M Randis, Adam J Ratner, Jennifer A Gaddy, Kevin Osteen, David M Aronoff
PROBLEM: Bacterial chorioamnionitis causes adverse pregnancy outcomes, yet host-microbial interactions are not well characterized within gestational membranes. The decidua, the outermost region of the membranes, is a potential point of entry for bacteria ascending from the vagina to cause chorioamnionitis. We sought to determine whether paracrine communication between decidual stromal cells and macrophages shaped immune responses to microbial sensing. METHOD OF STUDY: Decidual cell-macrophage interactions were modeled in vitro utilizing decidualized, telomerase-immortalized human endometrial stromal cells (dTHESCs) and phorbol ester-differentiated THP-1 macrophage-like cells...
August 7, 2018: American Journal of Reproductive Immunology: AJRI
Steven E Bosinger, Gregory K Tharp, Nirav B Patel, Chunxia Zhao, Tamika L Payne, Sharon Dietz Ostergaard, Katherine Butler, Shanon Ellis, Ryan L Johnson, Ellen N Kersh, Janet M McNicholl, Sundaram A Vishwanathan
PROBLEM: In women, the use of progestin-based contraception may increase the risk of vaginal HIV acquisition. We previously showed in macaques that there is a significantly higher simian-human immunodeficiency virus (SHIV) acquisition rate in the luteal phase of the menstrual cycle, which presents a naturally high-progesterone state, and this may be attributable to altered expression of innate immune factors. We hypothesized that progestin-based contraception, especially depot medroxyprogesterone acetate (DMPA), would, in a similar way, affect mucosal immune factors that influence HIV acquisition risk...
August 3, 2018: American Journal of Reproductive Immunology: AJRI
Rachelle N M Govia, Kenzie D Birse, Shadi Sepehri, Ehsan Khafipour, Savas M Menticoglou, Adam D Burgener, Vanessa Poliquin
PROBLEM: Cervical insufficiency is a precursor of preterm birth. Treatment with emergency cervical cerclage is contraindicated in the presence of intra-amniotic infection. Detecting infection with Gram stain and culture of amniotic fluid lacks sensitivity. Proteomic profiling of amniotic fluid in cervical insufficiency may help identify pregnancies best suited for emergency cerclage. METHOD OF STUDY: Thirty-two pregnant women underwent amniocentesis for routine genetic testing (n = 22) or after diagnosis of cervical insufficiency (n = 10)...
August 3, 2018: American Journal of Reproductive Immunology: AJRI
Haidy El-Azzamy, Svetlana V Dambaeva, Dimantha Katukurundage, Maria D Salazar Garcia, Annie Skariah, Youssef Hussein, Alfredo Germain, Emilio Fernandez, Alice Gilman-Sachs, Kenneth D Beaman, Joanne Kwak-Kim
PROBLEM: Angiogenesis and vascular remodeling in secretory endometrium represent one of the crucial steps in pregnancy establishment, for which uterine NK (uNK) cells have an important role. Impairment of these steps may proceed to implantation and instigate initial pathology of recurrent pregnancy losses (RPL). In this study, we aim to investigate vascular development and density of uNK cells in secretory endometrium of women with RPL. METHODS OF STUDY: Mid-secretory phase endometrial tissues from women with RPL (n = 15) and fertile controls (n = 7) were investigated...
July 31, 2018: American Journal of Reproductive Immunology: AJRI
Charu Kaushic
No abstract text is available yet for this article.
July 27, 2018: American Journal of Reproductive Immunology: AJRI
Daniela Reis Gonçalves, António Braga, Jorge Braga, António Marinho
Recurrent pregnancy loss (RPL) affects approximately 1%-2% of reproductive women. Auto- and cellular immune responses seem to be associated with RPL. Vitamin D (VD) has been shown to play a role in the modulation of the immune system. Effects of VD deficiency (VDD) in pregnancy have been associated with preeclampsia, gestational diabetes, fetal growth restriction, preterm labor, and sporadic spontaneous abortion (SA). We systematically reviewed articles that studied women with 2 or more SA and its association with VD...
July 27, 2018: American Journal of Reproductive Immunology: AJRI
Haley A Dupont, Jeff Lam, Matthew W Woods, Mohammed A Zahoor, Charu Kaushic
Although anti-retroviral treatments have significantly slowed down the spread of the HIV-1 pandemic, approximately 2 million new infections occur every year. The majority of new infections are in sub-Saharan Africa where rates of infection are much higher in women than men. Young women are disproportionately affected and have higher susceptibility to HIV-1. The complex interactions between HIV-1 and the female genital tract (FGT) and the mechanisms regulating susceptibility in women remain incompletely understood...
July 16, 2018: American Journal of Reproductive Immunology: AJRI
Xue Xu, Mei-Ying Liang, Sha Dou, Jian-Liu Wang, Xiao-Hui Zhang
PROBLEM: Evaluate the response rate of glucocorticoid (GC) and/or immunoglobulin (IVIg) therapy in severe thrombocytopenia of immune thrombocytopenia (ITP) pregnant patients and the influence on maternal and neonatal outcomes. METHOD OF STUDY: This is a prospective observational cohort study. Pregnant ITP patients with platelet count less than 30 × 109 /L and their newborn infants participated in this research. Over a 3-year period, 87 patients were allocated to 4 groups: group 1 (n = 18) were treated by oral prednisone, group 2 (n = 20) with IVIg, group 3 (n = 22) with prednisone/methlyprednisone plus IVIg, and group 4 were non-treatment controls (n = 27)...
July 16, 2018: American Journal of Reproductive Immunology: AJRI
Yin Mon Khine, Fuminori Taniguchi, Kei Nagira, Kazuomi Nakamura, Tetsuya Ohbayashi, Mitsuhiko Osaki, Tasuku Harada
PROBLEM: To evaluate the effects of SR-16234 (SR), a selective estrogen receptor modulator (SERM), on murine endometriosis-like lesions. METHOD OF STUDY: BALB/c mice (n = 53) were used to establish the murine endometriosis model. Ovariectomized, estradiol replaced, 6-week-old murine endometriosis model were injected with lipopolysaccharide (LPS) with or without SR (1 mg/kg/d) or vehicle, over a period of 4 weeks. Upon treatment completion, the endometriosis-like lesions that developed in the abdominal cavity of mice were counted, measured, and collected...
July 16, 2018: American Journal of Reproductive Immunology: AJRI
Takeshi Nagamatsu, Tatsuya Fujii, Danny J Schust, Naoko Tsuchiya, Yohei Tokita, Mari Hoya, Naoya Akiba, Takayuki Iriyama, Kei Kawana, Yutaka Osuga, Tomoyuki Fujii
OBJECTIVE: Tokishakuyakusan (TSS) is a traditional herbal medicine that has been used empirically to prevent recurrent pregnancy loss. Its mode of action remains unclear. With their potent capacity to produce cytokines, invariant natural killer (iNKT) cells are involved in the control of fetomaternal immunity in early gestation. This study aimed to clarify the effect of TSS on iNKT cell activities in a well-studied murine miscarriage model. METHODS: Pregnant mice were fed 1% TSS-containing or control diet from the day of vaginal plug formation...
July 12, 2018: American Journal of Reproductive Immunology: AJRI
Giuseppe Grande, Domenico Milardi, Silvia Baroni, Giovanni Luca, Alfredo Pontecorvi
Male accessory gland infection/inflammation (MAGI) is a frequent disease, mostly with a chronic course, involving 1 or more sexual accessory glands. Majority of the MAGIs remain asymptomatic, thereby leading to a dilemma whether to treat these patients or not. It is moreover noteworthy that the diagnosis of MAGI is difficult, since patients are frequently asymptomatic and semen samples or prostatic secretions are often free from bacteria. As a consequence the identification of novel and reliable markers of inflammation in seminal plasma is an open challenge...
July 10, 2018: American Journal of Reproductive Immunology: AJRI
Theresa L Barke, Jeffery A Goldstein, Alexandra C Sundermann, Arun P Reddy, Jodell E Linder, Hernan Correa, Digna R Velez-Edwards, David M Aronoff
PROBLEM: GDM has been associated with disturbances in iron homeostasis and exaggerated immune activation. We sought to investigate the extent to which placental iron storage and macrophage accumulations were altered in GDM. METHOD OF STUDY: We conducted a retrospective, case-control study of archived placental tissues obtained from 22 pregnancies complicated by GDM and 22 unaffected controls. Controls were matched to cases based on maternal age, gestational age at birth, and method of delivery...
July 9, 2018: American Journal of Reproductive Immunology: AJRI
Kahinho P Muyayalo, Zhi-Hui Li, Gil Mor, Ai-Hua Liao
Recurrent spontaneous abortion (RSA) is a growing problem worldwide. In a majority of cases, the cause remains unknown but there is increasing evidence that immunologic factors play an important role. Intravenous immunoglobulin (IVIg) therapy has been proposed to have immune modulatory effects and therefore been applicable for the treatment of patients with RSA. Although its efficacy is still controversial, several recent studies suggest that IVIg treatment may improve pregnancy outcomes. CD4+ T cells and their related cytokines play an important role in maternal-fetal immune regulation, and an imbalance of Th17/Treg cell ratio has been proposed as a cause for RSA...
July 9, 2018: American Journal of Reproductive Immunology: AJRI
Kelly K Ferguson, Elizabeth M Kamai, David E Cantonwine, Bhramar Mukherjee, John D Meeker, Thomas F McElrath
PROBLEM: Perturbations in normal fetal growth during pregnancy are associated with poor child and adult health outcomes. Inflammation and oxidative stress are recognized as important mechanisms in preeclampsia and preterm birth but have been examined less in relation to fetal growth. We hypothesized that maternal inflammation and oxidative stress in pregnancy would be associated with reduced fetal growth and sought to identify windows of vulnerability. METHOD OF STUDY: In a secondary analysis of 482 women from the LIFECODES birth cohort study, we measured inflammation (C-reactive protein [CRP] and the cytokines IL-1β, IL-6, IL-10, and TNF-α) and oxidative stress (8-isoprostane and 8-hydroxydeoxyguanosine [8-OHdG]) biomarkers in plasma and urine, respectively, at four time points during pregnancy...
July 8, 2018: American Journal of Reproductive Immunology: AJRI
Toshio Miki
Multiple stem cell types can be isolated from the human placenta. Recent advances in stem cell biology have revealed that human amniotic epithelial cells (hAECs) are one of the perinatal stem cells which possess embryonic stem cell-like differentiation capability and adult stem cell-like immunomodulatory properties. Unlike other types of placental stem cells, hAECs are derived from pluripotent epiblasts and maintain multilineage differentiation potential throughout gestation. Similar to mesenchymal stem cells, hAECs are also able to modulate the local immune response...
June 29, 2018: American Journal of Reproductive Immunology: AJRI
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