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American Journal of Reproductive Immunology: AJRI

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https://www.readbyqxmd.com/read/28543977/abnormal-ratio-of-cd57-cells-to-cd56-cells-in-women-with-recurrent-implantation-failure
#1
Ruiwei Jiang, Guijun Yan, Jun Xing, Zhilong Wang, Yong Liu, Hongyan Wu, Xiangshan Fan, Jianjun Zhou, Lijun Ding, Haixiang Sun
PROBLEM: To define a more precise parameter for a better understanding of natural killer (NK) cells and its relation with regulatory T cells (Tregs) in women with recurrent implantation failure (RIF). METHOD OF STUDY: The percentages of CD56+ cells, CD57+ cells and Foxp3+ cells in the endometrium and blood from 23 normal controls and 32 women with RIF were measured by immunocytochemistry and flow cytometry. RESULTS: Women with RIF had significantly increased ratio of CD57+ cells to CD56+ cells in both the endometrium (P<...
May 20, 2017: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/28544362/cxcl10-and-il-6-markers-of-two-different-forms-of-intra-amniotic-inflammation-in-preterm-labor
#2
Roberto Romero, Piya Chaemsaithong, Noppadol Chaiyasit, Nikolina Docheva, Zhong Dong, Chong Jai Kim, Yeon Mee Kim, Jung-Sun Kim, Faisal Qureshi, Suzanne M Jacques, Bo Hyun Yoon, Tinnakorn Chaiworapongsa, Lami Yeo, Sonia S Hassan, Offer Erez, Steven J Korzeniewski
PROBLEM: To determine whether amniotic fluid (AF) CXCL10 concentration is associated with histologic chronic chorioamnionitis in patients with preterm labor (PTL) and preterm prelabor rupture of the membranes (PROM). METHOD OF STUDY: This study included 168 women who had an episode of PTL or preterm PROM. AF interleukin (IL)-6 and CXCL10 concentrations were determined by immunoassay. RESULTS: (i) Increased AF CXCL10 concentration was associated with chronic (OR: 4...
May 19, 2017: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/28544232/peripartum-cytokine-flares-in-a-multiethnic-cohort-of-chronic-hepatitis-b-carriers-does-not-correlate-with-hepatitis-b-virus-suppression-or-increased-risk-of-liver-disease
#3
Shivali S Joshi, Daniel Wong, Eliana Castillo, Mark G Swain, Carla S Coffin
PROBLEM: In chronic hepatitis B (CHB) carriers, alanine transaminase (ALT) flares are common in the peripartum period. There are limited data on immunological changes of pregnancy in CHB. We hypothesize that in pregnant CHB carriers, the Th1/Th2 cytokine ratio is altered resulting in changes in biochemical/virological and liver fibrosis markers. STUDY METHODS: Serum from 38 pregnant/post-partum CHB carriers (median age 32 years, 53% Asian, 8 HBeAg(+) ) was tested for HBV DNA, quantitative HBV surface antigen, ALT and liver fibrosis by transient elastography (TE)...
May 19, 2017: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/28508475/functional-properties-of-peripheral-cd8-%C3%A2-t-cells-in-patients-with-repeated-implantation-failure
#4
Biao Yin, Yong Zeng, Tonghua Wu, Shuyi Yu, Jian Xu, Su Liu, Lianghui Diao, Zhenfu Zhao, Desheng Liang, Yuye Li
CD8(+) T cells are the main candidates to recognize and respond to fetal HLA-C at the fetal-maternal interface, but data on the amount of peripheral CD8(+) T cells and their functions during the window of implantation in recurrent implantation failure (RIF) patients are limited. Peripheral blood was obtained from 56 women with RIF and 16 fertile women in the mid-luteal phase of the menstrual cycle, and the CD8(+) T cells were determined by FACS analysis. No statistical differences in the proportion of peripheral CD8(+) T cells were observed among the women with RIF and the control group...
May 15, 2017: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/28508429/the-cross-talk-between-cervical-carcinoma-cells-and-vascular-endothelial-cells-mediated-by-il-27-restrains-angiogenesis
#5
Bing Zhang, Feng Xie, Chun-Lin Dong, Chun-Jie Gu, Jiao Cheng, Yuan Wang, Xi-Zhong Xu, Hong Pu, Yi-Bo Wu, Xiao-Wei Qi, Da-Jin Li, Jin-Jin Yu, Ming-Qing Li
PROBLEM: To explore whether cervical carcinoma cell-derived interleukin-27 (IL-27) modulates the angiogenesis of vascular endothelial cells. METHOD OF STUDY: The expression of IL-27 in cervical cancer tissues and cervical cell lines was analyzed by immunohistochemistry, ELISA and flow cytometry. Then, the effects of IL-27 on the proliferation and apoptosis-related molecules and angiogenesis in vitro of human umbilical vein endothelial cells (HUVECs) were investigated...
May 15, 2017: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/28508390/elevated-maternal-placental-protein-13-serum-levels-at-term-of-pregnancy-in-postpartum-major-hemorrhage-1000%C3%A2-mls-a-prospective-cohort-study
#6
Antonio Farina, Dalila Bernabini, Cinzia Zucchini, Paola De Sanctis, Maria Soledad Quezada, Mara Mattioli, Nicola Rizzo
PROBLEM: To compare placental protein 13 (PP13) levels in the serum of women with primary postpartum hemorrhage (PPH) with a control population. METHODS: A prospective cohort study was conducted between May 2014 and May 2016 and included 435 pregnant women at term (38 weeks gestation) without any known risk factor and with normal labor. Multiples of median (MoM) were used to evaluate differences of the PP13 values between cases and controls. PP13 concentrations were adjusted for maternal and neonatal weight...
May 15, 2017: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/28497897/expression-profile-of-heat-shock-proteins-in-placental-tissues-of-patients-with-preterm-prelabor-rupture-of-membranes-and-spontaneous-preterm-labor-with-intact-membranes
#7
Lenka Dvorakova, Katarina Ivankova, Ladislav Krofta, Ilona Hromadnikova
PROBLEM: Investigating the stress response in the central cotyledon zone of placental tissue in pregnancies with PPROM, PTB, and at term in labor. METHOD OF STUDY: Gene expression of Hsp27, Hsp60, Hsp70, Hsp90, and HspBP1 was compared between these particular groups. Correlation between variables including Hsp gene expression in placental tissue and the gestational age at delivery, WBC count at admission, and serum levels of CRP at admission in patients with PPROM and PTB was determined...
May 12, 2017: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/28497881/efficacy-of-intrauterine-perfusion-of-granulocyte-colony-stimulating-factor-g-csf-for-infertile-women-with-thin-endometrium-a-systematic-review-and-meta-analysis
#8
Yiran Xie, Tao Zhang, Zhengping Tian, Jiamiao Zhang, Wanxue Wang, Hong Zhang, Yong Zeng, Jianping Ou, Yihua Yang
This meta-analysis aimed to explore the efficiency of intrauterine perfusion of granulocyte colony-stimulating factor (G-CSF) on infertile women with thin endometrium. Following PRISMA protocol, we conducted a comprehensive search of academic literatures on various databases including PubMed, EMbase, and Cochrane Library. Studies published in English before July 1, 2016 were included for primary screening. Data on the thickness of endometrium, cycle cancelation rate,clinical pregnancy rate, and embryo implantation rate were extracted and analyzed, respectively...
May 12, 2017: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/28497869/increased-delta-neutrophil-index-in-women-with-severe-preeclampsia
#9
Hee Young Cho, Inkyung Jung, So Jung Kim, Yong Won Park, Young Han Kim, Ja-Young Kwon
PROBLEM: The pathophysiology of preeclampsia (PE) is believed to be associated with a systemic inflammatory response, but few inflammatory markers are currently available to predict PE. Therefore, the aim of this study was to compare the serum delta neutrophil index (DNI) between normal and preeclamptic women. METHODS: Sixty-five patients with mild preeclampsia (mPE), 147 patients with severe preeclampsia (sPE), and 163 women with normal pregnancy were included in this study...
May 12, 2017: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/28467001/challenges-in-conducting-research-on-sexual-violence-and-hiv-and-approaches-to-overcome-them
#10
REVIEW
Annette Aldous, Manya Magnus, Afsoon Roberts, Heather DeVore, Theresa Moriarty, Catherine Hatch Schultz, Maria Zumer, Gary Simon, Mimi Ghosh
Studies have implicated sexual violence as a strong correlate of HIV acquisition in women. Characterizing how such violence affects the female immune system may provide insight into the biological mechanisms of HIV transmission and ultimately improve global HIV prevention strategies. Little research has been carried out in this domain, and the obstacles to investigation can be daunting. Here, we describe methodological challenges encountered and solutions explored while implementing a study of dysregulation of immune biomarkers potentially indicative of increased HIV susceptibility in women following sexual assault...
May 3, 2017: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/28466996/hepatitis-a-virus-cellular-receptor-2-havcr2-is-decreased-with-viral-infection-and-regulates-pro-labour-mediators-oa
#11
Stella Liong, Ratana Lim, Gillian Barker, Martha Lappas
PROBLEM: Intrauterine infection caused by viral infection has been implicated to contribute to preterm birth. Hepatitis A virus cellular receptor 2 (HAVCR2) regulates inflammation in non-gestational tissues in response to viral infection. METHOD OF STUDY: The aims of this study were to determine the effect of: (i) viral dsRNA analogue polyinosinic:polycytidylic acid (poly(I:C)) on HAVCR2 expression; and (ii) HAVCR2 silencing by siRNA (siHAVCR2) in primary amnion and myometrial cells on poly(I:C)-induced inflammation...
May 3, 2017: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/28466977/immunosuppressive-treatment-using-tacrolimus-promotes-pregnancy-outcome-in-infertile-women-with-repeated-implantation-failures
#12
Koji Nakagawa, Joanne Kwak-Kim, Keiji Kuroda, Rikikazu Sugiyama, Koushi Yamaguchi
PROBLEM: We aim to investigate whether the peripheral blood T helper (Th) 1 cell level could predict pregnancy outcome in patients who have experienced repeated implantation failure (RIF, three or more) after ART cycles. METHOD OF STUDY: This is a prospective cohort study of total 124 women with RIF who showed elevated Th1/Th2 (CD4(+) IFN-γ(+) /CD4(+) IL-4(+) ) cell ratios (≥10.3) and received tacrolimus at Sugiyama Clinic between November 2011 and July 2016...
May 3, 2017: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/28466568/physiological-and-pathological-angiogenesis-in-endometrium-at-the-time-of-embryo-implantation
#13
Xiaoyan Chen, Gene Chi Wai Man, Yingyu Liu, Fangrong Wu, Jin Huang, Tin Chiu Li, Chi Chiu Wang
Embryo establishes contact with the endometrium during implantation. Proper endometrial vascular development and maintenance at the time of embryo implantation is crucial for successful pregnancy. Vascular development at the maternal-embryo interface can be regulated by various cell types, of which uterine natural killer (uNK) cells play an important role. Abnormal angiogenesis and uNK cell number/function may lead to reproductive failure, particularly in women with recurrent miscarriage (RM) and women with recurrent implantation failure (RIF) after IVF-ET treatment, which are the important clinical hurdles in reproductive medicine to overcome...
May 3, 2017: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/28440588/endometrial-immune-markers-are-potential-predictors-of-normal-fertility-and-pregnancy-after-in-vitro-fertilization
#14
Louise Kofod, Anette Lindhard, Michael Bzorek, Jens Ole Eriksen, Lise Grupe Larsen, Thomas Vauvert F Hviid
PROBLEM: Elucidating immune mechanisms in the endometrium, which lead to the success of implantation and pregnancy, is important in reproductive medicine. Studies of immune cell abundance have shown conflicting results, and the expression and importance of HLA class Ib proteins in pre-implantation endometrium have not yet been investigated. METHOD OF STUDY: The study population consisted of four subgroups: a hydrosalpinx, a salpingectomy, an unexplained infertility, and a fertile control group...
April 25, 2017: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/28440579/prevalence-of-herpes-simplex-virus-types-1-and-2-at-maternal-and-fetal-sides-of-the-placenta-in-asymptomatic-pregnant-women
#15
Fabiana Finger-Jardim, Emiliana C Avila, Vanusa P da Hora, Carla V Gonçalves, Ana Maria B de Martinez, Marcelo A Soares
PROBLEM: Herpes simplex virus 1 (HSV-1) commonly causes orolabial infection, but can also infect the genital mucosa. In contrast, HSV-2 is usually genital. Genital herpes can transmit the virus vertically to the fetus during pregnancy. We sought to estimate the prevalence of HSV-1/2 on the maternal and fetal sides of the placenta. METHOD OF STUDY: Placental tissues were collected from pregnant women seen at the Rio Grande University Hospital. HSV-1 and HSV-2 were detected by nested PCR...
April 25, 2017: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/28440564/hypoxia-inhibited-dusp2-expression-promotes-il-6-stat3-signaling-in-endometriosis
#16
Kuei-Yang Hsiao, Ning Chang, Jia-Ling Tsai, Shih-Chieh Lin, Shaw-Jenq Tsai, Meng-Hsing Wu
PROBLEM: How does hypoxia-mediated downregulation of dual-specificity phosphatase-2 (DUSP2) promote the development of endometriotic lesions? METHOD OF STUDY: The levels of IL-6 and DUSP2 were assessed in eutopic stromal cells with DUSP2 knockdown or hypoxia treatment. Bromodeoxyuridine (BrdU) incorporation was applied for evaluating cell proliferation. The protein levels of DUSP2, cleaved caspase-3, phosphorylated STAT3, and STAT3 were analyzed using immunoblot...
April 25, 2017: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/28429578/soy-isoflavones-enhance-%C3%AE-defensin-synthesis-and-secretion-in-endometrial-epithelial-cells-with-exposure-to-tlr3-agonist-polyinosinic-polycytidylic-acid
#17
Yotesawee Srisomboon, Sutthasinee Poonyachoti, Chatsri Deachapunya
PROBLEM: β-defensins are important innate chemical barriers that protect the endometrium from pathogen invasion. The effects of soy isoflavones, genistein and daidzein, on the expression and secretion of porcine β-defensins (PBD) in endometrial epithelial cells were investigated under normal or poly I:C-stimulated conditions. METHOD OF STUDY: Primary cultured porcine endometrial epithelial (PE) cells were pretreated with genistein or daidzein followed by poly I:C inoculation...
April 21, 2017: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/28397374/the-need-for-enhancing-the-message-screening-for-zika-storch-and-other-agents-and-co-infections-should-be-considered-and-assessed
#18
LETTER
Alfonso J Rodriguez-Morales, Carlos Culquichicón
No abstract text is available yet for this article.
April 11, 2017: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/28397318/characterization-of-immune-cells-and-infection-by-hiv-in-human-ovarian-tissues
#19
Zheng Shen, Marta Rodriguez-Garcia, Christina Ochsenbauer, Charles R Wira
PROBLEM: New HIV infections in women are predominantly spread through sexual intercourse. Recent non-human primate studies demonstrated that simian immunodeficiency virus (SIV) deposited in the vagina infected immune cells in the ovary. Whether immune cells in the human ovary are susceptible to HIV infection is unknown. METHOD OF STUDY: Immune cells were isolated from ovaries and characterized by flow cytometry. Cells were exposed to HIV for 2 hours. HIV infection was measured by flow cytometry and p24 secretion following 6 days in culture...
April 11, 2017: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/28382737/leukocyte-counts-and-lymphocyte-subsets-in-relation-to-pregnancy-and-hiv-infection-in-malawian-women
#20
Wilson L Mandala, Esther N Gondwe, Malcolm E Molyneux, Jenny M MacLennan, Calman A MacLennan
PROBLEM: We investigated leukocyte and lymphocyte subsets in HIV-infected or HIV-uninfected, pregnant or non-pregnant Malawian women to explore whether HIV infection and pregnancy may act synergistically to impair cellular immunity. METHOD OF STUDY: We recruited 54 pregnant and 48 non-pregnant HIV-uninfected women and 24 pregnant and 20 non-pregnant HIV-infected Malawian women. We compared peripheral blood leukocyte and lymphocyte subsets between women in the four groups...
April 6, 2017: American Journal of Reproductive Immunology: AJRI
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