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American Journal of Reproductive Immunology: AJRI

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https://www.readbyqxmd.com/read/28786549/obituary-leif-matthiesen-md-phd-1954-2017
#1
LETTER
Surendra Sharma, Goran Berg, Jan Ernerudh
No abstract text is available yet for this article.
August 8, 2017: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/28771916/vitamin-d-deficiency-in-an-italian-cohort-of-infertile-women
#2
Paola Triggianese, Abdulla Watad, Francesca Cedola, Carlo Perricone, Howard Amital, Ilio Giambini, Roberto Perricone, Yehuda Shoenfeld, Caterina De Carolis
PROBLEM: The purpose of this study was to explore whether vitamin D might be a marker of female primary infertility in association with the presence of autoimmune diseases (ADs). METHODS: The study was a cross-sectional descriptive study in consecutive outpatients of the Polymedical Center for Prevention of Recurrent Spontaneous Abortion (RSA), in Rome, Italy. Women were eligible if they received a diagnosis of primary infertility or RSA. Serum vitamin D, calcium, and PTH were analyzed...
August 3, 2017: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/28771871/predicting-nk-cell-subsets-using-gene-expression-levels-in-peripheral-blood-and-endometrial-biopsy-specimens
#3
Michael L Davies, Svetlana V Dambaeva, Dimantha Katukurundage, Miroslava Repak, Alice Gilman-Sachs, Joanne Kwak-Kim, Kenneth D Beaman
PROBLEM: In molecular analysis of tissue biopsy specimens, one crucial aspect is characterization of immune cell populations. This is especially important for evaluation of uterine receptivity by assessing levels of lymphocyte populations including CD56(bright) CD16- uterine NK cells and CD56(dim) CD16+ conventional NK cells. Our objective was to investigate whether measuring total RNA transcripts from a tissue specimen would accurately reflect immune cell levels and be a new technique to assess immune cell subsets...
August 3, 2017: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/28771858/intrauterine-delivery-of-subunit-vaccines-induces-a-systemic-and-mucosal-immune-response-in-rabbits
#4
Jonathan Alexander Pasternak, Glenn Hamonic, Nikki M Forsberg, Colette L Wheler, Michael K Dyck, Heather L Wilson
PROBLEM: Mucosal vaccines have long been sought after to improve protection though the production of both a mucosal and systemic immune response, and are thought to be particularly effective at the site of induction. Development of such vaccines has, however, been delayed by the general propensity to develop immune tolerance to antigens encountered at mucosal sites. This study aimed to determine whether an appropriately formulated subunit vaccine delivered to the uterine lumen would effectively trigger induction of immunity over tolerance...
August 3, 2017: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/28762599/diversity-of-progesterone-action-on-lipopolysaccharide-induced-expression-changes-in-cultured-human-cervical-fibroblasts-according-to-inflammation-and-treatment-timing
#5
Yoshimitsu Kuwabara, Akira Katayama, Sachiko Kurihara, Marie Ito, Mirei Yonezawa, Nozomi Ouchi, Ryuhei Kurashina, Tomoko Ichikawa, Rintaro Sawa, Akihito Nakai, Hideo Orimo, Toshiyuki Takeshita
PROBLEM: The effectiveness of progesterone (P4) treatment for preventing preterm births is unclear. Its effects on the uterine cervix were tested using cultured human uterine cervical fibroblasts (UCFs). METHOD OF STUDY: UCFs were incubated with lipopolysaccharide (LPS) in the presence or absence of P4 under various conditions. mRNA was subjected to PCR arrays and real-time RT-PCR to assess IL-6, IL-8, IL-1beta, PTGS2, MMP-1, and CXCL10 expression. RESULTS: When exposed to a high-LPS concentration (2...
August 1, 2017: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/28681959/a-novel-in-vitro-model-of-villitis-of-unknown-etiology-demonstrates-altered-placental-hormone-and-cytokine-profile
#6
Hayley Derricott, Alexander E P Heazell, Susan L Greenwood, Rebecca L Jones
PROBLEM: Placental dysfunction is present over 50% of cases of stillbirth and fetal growth restriction (FGR). Villitis of unknown etiology (VUE), an inflammatory condition of the placenta characterized by maternal T cell infiltrates in the villous stroma and dysregulation of inflammatory cytokines, is more frequent in FGR and stillbirth. METHOD OF STUDY: A novel in vitro model of placental inflammation was developed to test the hypothesis that inflammatory cells seen in VUE and/or cytokines impair placental function...
July 6, 2017: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/28681517/increased-expression-of-resistin-in-ectopic-endometrial-tissue-of-women-with-endometriosis
#7
Yoon Kyung Oh, Young Ran Ha, Kyong Wook Yi, Hyun Tae Park, Jung-Ho Shin, Tak Kim, Jun-Young Hur
PROBLEM: Inflammation is a key process in the establishment and progression of endometriosis. Resistin, an adipocytokine, has biological properties linked to immunologic functions, but its role in endometriosis is unclear. METHOD OF STUDY: Resistin gene expression was examined in eutopic and ectopic endometrial tissues from women with (n=25) or without (n=25) endometriosis. Resistin mRNA and protein levels were determined in endometrial tissue using quantitative real-time reverse transcription PCR and Western blotting, following adipokine profiling arrays...
July 6, 2017: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/28681467/proliferation-of-endogenous-regulatory-t-cells-improve-the-pathophysiology-associated-with-placental-ischaemia-of-pregnancy
#8
Tarek Ibrahim, Lukasz Przybyl, Ashlyn C Harmon, Lorena M Amaral, Jessica L Faulkner, Denise C Cornelius, Mark W Cunningham, Thomas Hünig, Florian Herse, Gerd Wallukat, Ralf Dechend, Babbette LaMarca
PROBLEM: Preeclampsia (PE) is associated with inflammation and decreased Treg cells and IL-10. The reduced uterine perfusion pressure (RUPP) rat model of PE exhibits these characteristics, and we hypothesized that induction of endogenous Tregs by a specific stimulus (CD28 superagonistic monoclonal antibody) would reduce inflammation, vasoactive factors, and hypertension in RUPP rats. METHOD OF STUDY: RUPP was performed at gestation day (GD) 14; CD28 superagonist was administered intraperitoneally GD15; GD18 carotid catheters were inserted, and GD19 MAP and pup weight, blood, and tissues were collected...
July 6, 2017: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/28660639/the-role-of-regulatory-t-cells-in-thymectomy-induced-autoimmune-ovarian-disease
#9
Yajun Dong, Hongmei Li, Yuyan Li, Yonggang Liu, Huiling Chen, Pingping Xu, Tingting Zhao, Wei He
PROBLEM: To evaluate the role of regulatory T (Treg) cells in autoimmune ovarian disease (AOD). METHOD OF STUDY: AOD model was set up by thymectomy of BALB/C mice on day 3 (d3tx). The variation of T lymphocyte subsets, especially the Treg cells were analyzed in the peripheral blood, spleen, para-aortic, and inguinal lymph nodes in d3tx mice. The effect of Treg cells on AOD was further evaluated by adoptive transfer of Treg cells into d3tx mice (d3tx+Treg). RESULTS: In d3tx mice, the ratio of Treg/CD4(+) was significantly increased rapidly from 1st to 2nd week, rapidly declined in 3rd week, then decreased slowly until the 9th week...
June 29, 2017: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/28653491/the-role-of-%C3%AE-%C3%AE-t-cells-during-human-pregnancy
#10
Chunyu Huang, Yong Zeng, Wenwei Tu
Pregnancy is an evolutionarily important and mysterious process. The placenta, as the nutrient and gas exchange organ, plays an essential role during this process. In addition, the interaction between trophoblast and maternal immune cells at the maternal-fetal interface is also associated with successful pregnancy. Human leukocyte antigen (HLA) molecules on trophoblast cells are involved in protecting the fetus from maternal rejection. Trophoblast cells comprise three subpopulations, including syncytiotrophoblast cells, cytotrophoblast cells, and extravillous trophoblast cells, and these cells express different HLA molecules...
June 27, 2017: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/28653441/prior-pregnancy-and-antenatal-rubella-sero-negativity-evidence-of-persistent-maternal-immunologic-alteration
#11
Terence T Lao, Annie S Y Hui, Daljit S Sahota
PROBLEM: It is unclear if the immunologic alterations induced by pregnancy could persist. METHOD OF STUDY: Antenatal rubella sero-negativity was correlated with gravidity, abortions and parity in 112 083 gravidae managed during 1997-2015, with further analysis stratified for factors known to influence rubella serology. RESULTS: The 10.2% sero-negative gravidae had different characteristics, and the incidence showed significant difference and positive trend (P<...
June 27, 2017: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/28653360/identification-of-genes-dysregulated-by-elevation-of-microrna-210-levels-in-human-trophoblasts-cell-line-swan-71
#12
Sejin Ahn, Eunbee Jeong, Jae Woong Min, Eunhee Kim, Sun Shim Choi, Chong Jae Kim, Deug-Chan Lee
PROBLEM: Preeclampsia is a serious pregnancy disorder characterized by gestational hypertension and proteinuria. miR-210 is significantly overexpressed in the placentas of preeclampsia patients. METHOD OF STUDY: Swan 71 cells, first-trimester human trophoblastic cell line, were transfected with hsa-miR-210-3p oligonucleotides by electroporation. Altered transcriptome was analyzed using microarray technique. Differentially expressed genes (DEGs) were clustered into Gene Ontology annotation biological processes...
June 27, 2017: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/28639391/an-investigation-of-the-relationship-between-recurrent-spontaneous-abortion-and-memory-t-follicular-helper-cells
#13
Xiaorui Luan, Xiaomin Kang, Weiping Li, Qian Dong
PROBLEM: Immune tolerance with respect to a semi-allogeneic fetus plays a key role in the establishment of a pregnancy. Memory T follicular helper (Tfh) cells have a central role in the regulation of the adaptive immune response. Much of our knowledge of memory Tfh cells' function comes from immune-related diseases. However, the true physiological characteristics of memory Tfh cells and their mode of action in pregnancy remain unclear. METHODS OF STUDY: Deciduas and blood were obtained from 25 recurrent spontaneous abortion (RSA) patients undergoing surgical abortion and 19 normal women in early pregnancy undergoing elective termination...
June 21, 2017: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/28639334/uterine-natural-killer-cells-in-patients-with-idiopathic-recurrent-miscarriage
#14
Ruben-J Kuon, Maja Weber, Julia Heger, Isabel Santillán, Kilian Vomstein, Christin Bär, Thomas Strowitzki, Udo R Markert, Bettina Toth
PROBLEM: Uterine natural killer (uNK) cells are major players during implantation and early pregnancy. The aim of our study was to analyze uNK cell concentration in the endometrium of idiopathic recurrent miscarriage (iRM) patients and fertile controls. METHOD OF STUDY: Out of n=130 couples with ≥3 consecutive, clinical RM screened according to a standardized diagnostic protocol, n=58 patients with iRM were identified. Endometrial biopsies were investigated in patients and n=17 fertile women (controls) via immunohistochemistry...
June 21, 2017: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/28635072/plgf-enhances-tlr-dependent-inflammatory-responses-in-human-mononuclear-phagocytes
#15
Laura F Newell, Shernan G Holtan, Jane E Yates, Leonardo Pereira, Jeffrey W Tyner, Irina Burd, Grover C Bagby
PROBLEM: Levels of placental growth factor (PlGF) peak during third trimester of pregnancy, a time when women are at increased risk of virus-induced morbidity. We hypothesized PlGF might contribute to an exaggerated inflammatory response to Toll-like receptor (TLR) activation. METHOD OF STUDY: Primary human adult and cord blood CD14(+) cells were cultured in the presence of TLR ligands and/or PlGF. RESULTS: PlGF significantly enhanced the magnitude and duration of TNF messenger RNA and protein production by TLR-7/8-activated monocytes, and increased subsequent production of TNF-independent inflammatory cytokines...
June 20, 2017: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/28608596/live-birth-rate-following-oral-antibiotic-treatment-for-chronic-endometritis-in-infertile-women-with-repeated-implantation-failure
#16
Kotaro Kitaya, Hidehiko Matsubayashi, Yukiko Takaya, Rie Nishiyama, Kohei Yamaguchi, Takumi Takeuchi, Tomomoto Ishikawa
PROBLEM: The aim of this prospective study was to investigate the prevalence of chronic endometritis (CE) in infertile women with a history of repeated implantation failure (RIF) and to determine whether oral antibiotic treatment improves their live birth rate in the following embryo transfer (ET) cycles. METHOD OF STUDY: Endometrial biopsy samples obtained from infertile women with RIF were subjected to immunohistochemistrical/histopathologic diagnosis of CE. Following antibiotic administration to the RIF/CE group, their histopathologic cure rate, microbial detection rate, and reproductive outcome in the subsequent ET cycles were prospectively studied...
June 13, 2017: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/28608468/toll-like-receptor4-as-a-modulator-of-fertilization-and-subsequent-pre-implantation-development-following-in-vitro-maturation-in-mice
#17
Sara Hosseini, Maryam Dehghani-Mohammadabadi, Marefat Ghafarri Novin, Mostafa Haji Molla Hoseini, Ehsan Arefian, Samira Mohammadi Yeganeh, Mohammad Salehi
PROBLEM: The use of in vitro maturation (IVM) as an alternative approach to the conventional assisted reproductive technique in clinical practice is limited due to low fertilization rate. The expression of Toll-like receptors (TLRs) as members of an innate immune system in cumulus cells are thought to affect fertilization. This study was aimed to evaluate the effect of IVM on TLR4 gene expression and fertilization rate in oocytes derived from IVM in comparison with in vivo matured one...
June 13, 2017: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/28593707/soluble-ceacam1-and-ceacam6-are-differently-expressed-in-blood-serum-of-pregnant-women-during-normal-pregnancy
#18
Pawel Mach, Alexandra Gellhaus, Sebastian Prager, Tom Moore, Gunther Wennemuth, Rainer Kimmig, Angela Köninger, Bernhard B Singer
PROBLEM: CEACAM1 and CEACAM6 belong to the carcinoembryonic antigen (CEA) family and may play an immune-modulatory role during pregnancy. The aim of the study was to determine the blood serum levels of soluble CEACAM1 and CEACAM6 over the course of pregnancy and postpartum. METHOD OF STUDY: CEACAM1 and CEACAM6 levels were determined with customized in-house Sandwich-enzyme-linked immunosorbent assay (ELISA) systems. The study population (n=125) was divided into four groups according to the pregnancy trimester and postpartum...
June 8, 2017: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/28590025/apobec3g-is-increasingly-expressed-on-the-human-uterine-cervical-intraepithelial-neoplasia-along-with-disease-progression
#19
Takashi Iizuka, Kousho Wakae, Mitsuhiro Nakamura, Koichi Kitamura, Masanori Ono, Hiroshi Fujiwara, Masamichi Muramatsu
PROBLEM: APOBEC3G (A3G) is a cytidine deaminase that exhibits antiviral activity by introducing C-to-T hypermutation in viral DNA. We recently observed the distinct presence of C-to-T hypermutation of human papillomavirus DNA in uterine cervical intraepithelial neoplasia (CIN), suggesting the possible involvement of A3G in the mutation-inducing process. Consequently, we investigated the association of A3G expression with CIN progression in this study. METHOD OF STUDY: Patients who had undergone cervical conization due to CIN1 (n=11), CIN2 (n=9), CIN3 (n=12), and micro-invasive squamous cell carcinoma (n=2) were included...
June 7, 2017: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/28585775/the-roles-of-the-pd-1-pd-l1-pathway-at-immunologically-privileged-sites
#20
Li-Ling Wang, Zhi-Hui Li, Xiao-Hui Hu, Kahinho P Muyayalo, Yong-Hong Zhang, Ai-Hua Liao
The PD-1/PD-L1 pathway plays a vital role in the maintenance of peripheral tolerance, promoting the development and function of regulatory T cells, and maintaining the quiescence of autoreactive T cells. Abnormalities in this inhibitory pathway are involved in the pathogenesis of some disorders such as tumours, autoimmune diseases, pregnancy complications, and transplantation rejection. Immune privilege represents a special immunological condition, where foreign antigens can be tolerated and do not elicit an immune response...
June 6, 2017: American Journal of Reproductive Immunology: AJRI
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