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American Journal of Reproductive Immunology: AJRI

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https://www.readbyqxmd.com/read/29450939/unexplained-infertility-patients-present-the-mostly-impaired-levels-of-progesterone-receptors-prospective-observational-study
#1
Stamatios Petousis, Yannis Prapas, Chrysoula Margioula-Siarkou, Konstantinos Ravanos, Stefanos Milias, George Mavromatidis, Ioannis Kalogiannidis, Costas Haitoglou, Apostolos Athanasiadis, Nikolaos Prapas, David Rousso
PROBLEM: Τo assess the endometrial expression of progesterone receptors in various subgroups of infertile women during implantation window. ΜETHODS: A prospective observational study was performed during March 2013-February 2017. Infertile women were categorized to those with tubal factor, ovarian failure, endometriosis or unexplained infertility. Endometrial biopsy was obtained on 7th-8th postovulatory day. Total progesterone receptors' PR(A + B) and type-B receptors' (PR-B) expression were compared between all categories of infertile and fruitful controls...
February 16, 2018: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/29446169/oxygen-concentration-modulates-cellular-senescence-and-autophagy-in-human-trophoblast-cells
#2
Kotomi Seno, Nao Tanikawa, Hironori Takahashi, Akihide Ohkuchi, Hirotada Suzuki, Shigeki Matsubara, Hisataka Iwata, Takehito Kuwayama, Koumei Shirasuna
PROBLEM: We investigated the effect of oxygen concentrations on cellular senescence and autophagy and examined the role of autophagy in human trophoblast cells. METHOD OF STUDY: Human first-trimester trophoblast cells (Sw.71) were incubated under 21%, 5%, or 1% O 2 concentrations for 24 hours. We examined the extent of senescence caused using senescence-associated β-galactosidase (SA-β-Gal) and senescence-associated secretory phenotype (SASP) as markers. Moreover, we examined the role of autophagy in causing cellular senescence using an autophagy inhibitor (3-methyladenine, 3MA)...
February 15, 2018: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/29430761/nod-like-receptor-pyrin-domain-containing-3-nlrp3-regulates-inflammation-induced-pro-labor-mediators-in-human-myometrial-cells
#3
Ratana Lim, Martha Lappas
PROBLEM: Inflammation plays a major role in preterm birth. Nucleotide-binding oligomerization domain-like receptor pyrin domain-containing-3 (NLRP3) plays a role in inflammatory diseases. The aims of this study were to determine the effect of term labor on the expression of NLRP3 in human myometrium and the effect of NLRP3 silencing on pro-labor mediators in myometrial cells. METHOD OF STUDY: NLRP3 expression was assessed in myometrium from non-laboring and laboring women by qRT-PCR and Western blotting...
February 12, 2018: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/29427369/pre-eclampsia-affects-procalcitonin-production-in-placental-tissue
#4
Chiara Agostinis, Damiano Rami, Paola Zacchi, Fleur Bossi, Tamara Stampalija, Alessandro Mangogna, Leonardo Amadio, Romana Vidergar, Liza Vecchi Brumatti, Giuseppe Ricci, Claudio Celeghini, Oriano Radillo, Ian Sargent, Roberta Bulla
PROBLEM: Procalcitonin (PCT) is the prohormone of calcitonin which is usually released from neuroendocrine cells of the thyroid gland (parafollicular) and the lungs (K cells). PCT is synthesized by almost all cell types and tissues, including monocytes and parenchymal tissue, upon LPS stimulation. To date, there is no evidence for PCT expression in the placenta both in physiological and pathological conditions. METHOD: Circulating and placental PCT levels were analysed in pre-eclamptic (PE) and control patients...
February 10, 2018: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/29427299/herpes-simplex-virus-type-2-igg-antibodies-in-sera-of-umbilical-cord-as-a-proxy-for-placental-infection-in-asymptomatic-pregnant-women
#5
Fabiana Finger-Jardim, Emiliana Claro Avila, Vanusa Pousada da Hora, Paula Costa Dos Santos, Carla Vitola Gonçalves, Gil Mor, Ana Maria Barral de Martinez, Marcelo Alves Soares
PROBLEM: Herpes simplex virus type 2 (HSV-2) infection is one of the most prevalent diseases worldwide and is mainly sexually transmitted. When infecting pregnant women, HSV-2 is able to infect the placenta, can reach the fetus, and may affect the fetal development. We sought to determine the prevalence of HSV-2 infection and reactivation in asymptomatic pregnant women, the correlation between IgG in the maternal circulation and cord blood, and the correlation between circulating IgG, placental, and newborn infection (blood cord)...
February 10, 2018: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/29418036/in-memory-of-dr-koji-koyama
#6
LETTER
Hiroaki Shibahara
No abstract text is available yet for this article.
February 8, 2018: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/29418026/transcriptional-profiling-of-primary-endometrial-epithelial-cells-following-acute-hiv-1-exposure-reveals-gene-signatures-related-to-innate-immunity
#7
Muhammad Atif Zahoor, Matthew William Woods, Sara Dizzell, Aisha Nazli, Kristen M Mueller, Philip V Nguyen, Chris P Verschoor, Charu Kaushic
PROBLEM: Genital epithelial cells (GECs) line the mucosal surface of the female genital tract (FGT) and are the first cells that interface with both commensal microbiota and sexually transmitted pathogens. Despite the protective barrier formed by GECs, the FGT is a major site of HIV-1 infection. This highlights the importance of studying the interaction of HIV-1 and GECs. METHOD OF STUDY: Using microarray analysis, we characterized the transcriptional profile of primary endometrial GECs grown in the presence or absence of physiological levels of E2 (10-9  mol/L) or P4 (10-7  mol/L) following acute exposure to HIV-1 for 6 hours...
February 8, 2018: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/29380456/uterine-natural-killer-cell-progenitor-populations-predict-successful-implantation-in-women-with-endometriosis-associated-infertility
#8
Louise E Glover, David Crosby, Uma Thiruchelvam, Cathal Harmon, Cáit Ni Chorcora, Mary B Wingfield, Cliona O'Farrelly
PROBLEM: Uterine natural killer (uNK) cells play a critical role early in gestation. As we previously identified altered uNK cell development in endometriosis-associated infertility, we herein sought to characterize natural killer (NK) cell profiles in endometriosis that may predict embryo implantation. METHOD OF STUDY: Study participants had a surgical diagnosis of endometriosis-associated infertility. Endometrial tissue and peripheral blood were obtained from 58 women...
January 30, 2018: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/29369434/lipopolysaccharide-induced-maternal-inflammation-induces-direct-placental-injury-without-alteration-in-placental-blood-flow-and-induces-a-secondary-fetal-intestinal-injury-that-persists-into-adulthood
#9
Erin M Fricke, Timothy G Elgin, Huiyu Gong, Jeff Reese, Katherine N Gibson-Corley, Robert M Weiss, Kathy Zimmerman, Noelle C Bowdler, Karen M Kalantera, David A Mills, Mark A Underwood, Steven J McElroy
PROBLEM: Premature birth complicates 10%-12% of deliveries. Infection and inflammation are the most common etiologies and are associated with increased offspring morbidity and mortality. We hypothesize that lipopolysaccharide (LPS)-induced maternal inflammation causes direct placenta injury and subsequent injury to the fetal intestine. METHOD OF STUDY: Pregnant C57Bl6 mice were injected intraperitoneally on day 15.5 with 100 μg/kg LPS or saline. Maternal serum, amniotic fluid, placental samples, and ileal samples of offspring were obtained assessed for inflammation and/or injury...
January 25, 2018: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/29363849/impact-of-th1-th2-cytokine-polarity-induced-by-invariant-nkt-cells-on-the-incidence-of-pregnancy-loss-in-mice
#10
Mari Hoya, Takeshi Nagamatsu, Tatsuya Fujii, Danny J Schust, Hiroko Oda, Naoya Akiba, Takayuki Iriyama, Kei Kawana, Yutaka Osuga, Tomoyuki Fujii
OBJECTIVE: This study aimed to investigate the association of Th1/Th2 polarity induced by CD1d-restricted invariant natural killer T (iNKT) cells with pregnancy outcome. METHODS: Two types of iNKT cell stimulants with different cytokine induction properties, alpha-galactosylceramide (AGC; Th1-biased inducer), and a sphingosine-truncated derivative of AGC (OCH; Th2-biased inducer) were administered to pregnant mice on day 9.5 post-coitus (pc), and the incidence of pregnancy loss was evaluated...
January 24, 2018: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/29350445/application-of-computer-aided-sperm-analysis-casa-for-detecting-sperm-immobilizing-antibody
#11
Yu Wakimoto, Atsushi Fukui, Teruhito Kojima, Akiko Hasegawa, Minoru Shigeta, Hiroaki Shibahara
PROBLEM: Since the 1970s, anti-sperm antibodies have been studied as a pathogenic factor contributing to infertility. The complement-dependent sperm-immobilization test (SIT) and quantitative SIT have been used as effective tools for detecting anti-sperm antibodies in clinical settings. These tests have been carried out traditionally by manually counting the number of motile sperm through eye estimation. METHOD OF STUDY: In this study, we developed a novel method using computer-aided sperm analysis...
January 19, 2018: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/29345808/immune-protective-effects-of-chitooligosaccharides-on-mice-genital-tract-infected-by-chlamydia-trachomatis
#12
Li Qian, Linjun Chen
PROBLEM: The immune protective effects of chitooligosaccharides (COs) on mouse genital tract infected by Chlamydia trachomatis (Ct) were unknown. METHODS: The minimum effective/infective dose was obtained by establishing the murine model of the genital tract infected by Ct. The model mice were treated with different doses (0.1, 0.2, and 0.3 g/kg,) of COs and 0.9% saline, and the serum immunoglobulin G (IgG) antibody and interleukin (IL)-11 levels were then assayed...
January 18, 2018: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/29323435/soluble-cd14-levels-in-plasma-and-breastmilk-of-malawian-hiv-women-lack-of-association-with-morbidity-and-mortality-in-their-exposed-infants
#13
Silvia Baroncelli, Clementina M Galluzzo, Giuseppe Liotta, Mauro Andreotti, Fausto Ciccacci, Sandro Mancinelli, Victor T Tolno, Jane Gondwe, Roberta Amici, Maria C Marazzi, Stefano Vella, Marina Giuliano, Leonardo Palombi, Lucia Palmisano
PROBLEM: Data on soluble CD14 (sCD14) during pregnancy and lactation are scarce. We assessed the levels of sCD14 in plasma and breastmilk of Malawian HIV-positive women and evaluated the possible association with morbidity and mortality in the HIV-exposed children. METHOD OF STUDY: One hundred and forty-nine mother/child pairs were studied. Women received antiretroviral therapy from 26 weeks of gestation to at least 6 months of exclusive breastfeeding. sCD14 concentrations were determined using an enzyme-linked immunosorbent assay...
January 11, 2018: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/29315988/impaired-treg-and-nk-cells-profile-in-overweight-women-with-gestational-diabetes-mellitus
#14
Thalita Frutuoso Lobo, Camila de Moraes Borges, Rosiane Mattar, Caio Perez Gomes, Ana Geisa Santos de Angelo, Karen Priscilla Tezotto Pendeloski, Silvia Daher
PROBLEM: Maternal obesity is frequently associated with gestational diabetes mellitus (GDM), and immunological mechanisms seem to be involved in the physiopathology of these conditions. The aim of this study was to characterize the profile of immune cells in peripheral blood of overweight women with GDM. METHOD OF STUDY: This case-control study included 27 glucose-tolerant (controls) and 31 GDM overweight pregnant women. Flow cytometry was used to assess the number of regulatory T cells (Treg) and natural killer (NK) cells in the peripheral blood...
January 5, 2018: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/29288552/effects-of-intrauterine-perfusion-of-human-chorionic-gonadotropin-in-women-with-different-implantation-failure-numbers
#15
Pinxiu Huang, Lihong Wei, Xinlin Li, Aiping Qin
PROBLEM: The aim of this research was to investigate the effects of the intrauterine perfusion of hCG before a frozen-thawed embryo transfer (FET) in women with different implantation failure numbers. METHOD OF STUDY: This was a retrospective analysis of patients undergoing FET who received an intrauterine injection hCG 1000 IU before embryo transfer. The groups included women with their first implantation failure (A group, n = 26), second implantation failure (B group, n = 122), and three or more failures (C group, n = 77)...
December 30, 2017: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/29288509/cancer-immunotherapy-a-need-for-peripheral-immunodynamic-monitoring
#16
REVIEW
Wenjun Wang, Xiaojun Xia, Sipei Wu, Minzhang Guo, Puyi Lie, Jianxing He
Immunotherapy has become an important approach for treating different tumours which has shown significant efficacy in numerous clinical trials, especially those using new checkpoint inhibitors and adoptive cell therapy, which have rapidly become widespread after being approved. However, analysis of peripheral immune biomarkers before and after immunotherapy and their relationship to clinical responses and disease prognosis have rarely been performed in clinical trials. In this review, we examine dynamic changes in the immune system before and after therapy by analyzing recent clinical trials of immunotherapy in patients with cancer that focused on checkpoint inhibitors and adoptive cell therapy...
December 30, 2017: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/29286179/localized-cyclical-variations-in-immunoproteins-in-the-female-genital-tract-and-the-implications-on-the-design-and-assessment-of-mucosal-infection-and-therapies
#17
Julia Makinde, Clifford Jones, Angela Bartolf, Sengeziwe Sibeko, Susan Baden, Catherine Cosgrove, Robin J Shattock
PROBLEM: Fluctuating hormones regulate reproductive processes in the female genital tract. Consequent changes in the local immunological environment are likely to affect cellular interaction with infectious agents and the assessment of therapies that target mucosal infections. METHOD OF STUDY: We compared Softcup and Weck-Cel sampling protocols and assessed the changes in the concentrations of 39 soluble proteins with menstrual cycle progression in the mucosal and peripheral compartments...
December 29, 2017: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/29286178/toll-like-receptor-variants-and-cervical-atopobium-vaginae-infection-in-women-with-pelvic-inflammatory-disease
#18
Brandie D Taylor, Patricia A Totten, Sabina G Astete, Michael J Ferris, David H Martin, Roberta B Ness, Catherine L Haggerty
PROBLEM: Toll-like (TLR) receptor genetic variants have been implicated in bacterial vaginosis (BV). We determined whether TLR variants are associated with fastidious BV-associated microbes that are linked with infertility following pelvic inflammatory disease (PID). METHOD OF STUDY: Sneathia spp., Atopobium vaginae, BVAB1, and Ureaplasma urealyticum were measured in 250 women from the PID Evaluation and Clinical Health (PEACH) study. Relative risk (RR) and 95% confidence intervals (CI) were calculated adjusting for chlamydia and gonorrhea...
December 29, 2017: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/29280532/sludge-reflects-intra-amniotic-inflammation-with-or-without-microorganisms
#19
Noriko Yoneda, Satoshi Yoneda, Hideki Niimi, Masami Ito, Kaori Fukuta, Tomohiro Ueno, Mika Ito, Arihiro Shiozaki, Mika Kigawa, Isao Kitajima, Shigeru Saito
PROBLEM: To investigate whether amniotic fluid (AF) "sludge" in patients with preterm labor (PTL) with intact membranes is related to intra-amniotic infection or inflammation. METHOD OF STUDY: 105 PTL patients before 29 weeks' gestation were enrolled. AF "sludge" was evaluated by transvaginal sonography. Microorganisms were identified in AF by our newly established PCR method using a eukaryote-made thermostable DNA polymerase. RESULTS: AF "sludge" was present in 18...
December 27, 2017: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/29271540/characterization-of-cd127-%C3%A2-cd25-treg-from-human-colostrum
#20
Arturo Cérbulo-Vázquez, Graciela Hernández-Peláez, Lourdes A Arriaga-Pizano, Paulina Bautista-Pérez, Jannett Romero-Venado, Julio C Flores-González, Ricardo Figueroa-Damian, Diana Soriano-Becerril, Ismael Mancilla-Herrera
PROBLEM: Breastfeeding's influence on the tolerance to environmental antigens is essential for short- and long-term homeostasis for children. Colostrum is rich in leucocytes, but it is unknown whether regulatory T cells (Treg) account for part of this cell population. METHOD OF STUDY: Frequencies of CD127-  CD25++ Treg and levels of immunoregulatory-associated cell markers were determined in colostrum and were compared with autologous blood cells. In addition, we evaluated whether the birth conditions can affect these features...
December 22, 2017: American Journal of Reproductive Immunology: AJRI
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