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American Journal of Reproductive Immunology: AJRI

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https://www.readbyqxmd.com/read/28194828/mitochondrial-dysfunction-and-ovarian-aging
#1
Tianren Wang, Man Zhang, Zongliang Jiang, Emre Seli
Mitochondria are double-membrane-bound organelles that are responsible for the generation of most of the cell's energy. Mitochondrial dysfunction has been implicated in cellular senescence in general and ovarian aging in particular. Recent studies exploited this association by studying mitochondrial DNA (mtDNA) copy number as a potential biomarker of embryo viability and the use of mitochondrial nutrients and autologous mitochondrial transfer as a potential treatment for poor ovarian function and response.
February 13, 2017: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/28194826/mapping-out-p38mapk
#2
Elizabeth A Bonney
To generate new hypotheses, sometimes a "systems" approach is needed. In this review, I focus on the mitogen-activated kinase p38 because it has been recently shown to play an important role in the developmental programing and senescence of normal and stressed reproductive tissues. What follows is an overview of (i) pathways of p38 activation and their involvement in basic biological processes, (ii) evidence that p38 is involved in the homeostasis of reproductive tissues, (iii) how focus on p38 can be incorporated into investigation of normal and stressed pregnancies...
February 13, 2017: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/28194822/autophagy-regulation-of-physiological-and-pathological-processes-in-the-female-reproductive-tract
#3
Bin Cao, Alison J Camden, Lindsay A Parnell, Indira U Mysorekar
Autophagy is a ubiquitous cell recycling pathway that delivers cytoplasmic constituents to the lysosome and is essential for normal cellular function. Autophagic activity is up-regulated under physiological conditions as well as stressful conditions such as nutrient deprivation, oxidative stress, hypoxia, inflammation, and infection. Thus, it is essential to regard the functional importance of the pathway and its components in a given tissue context. Here we review what is known about the involvement of autophagy process during physiological processes in the female reproductive tract and in pregnancy from preimplantation to oocyte function to placental development, parturition, and postpartum remodeling of the uterus; as well as in pathological and adverse events during these processes...
February 13, 2017: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/28185389/palmitic-acid-stimulates-interleukin-8-via-the-tlr4-nf-%C3%AE%C2%BAb-ros-pathway-and-induces-mitochondrial-dysfunction-in-bovine-oviduct-epithelial-cells
#4
Ayaka Ohtsu, Hazuki Tanaka, Kotomi Seno, Hisataka Iwata, Takehito Kuwayama, Koumei Shirasuna
PROBLEM: We investigated the effect of palmitic acid (PA), a major saturated fatty acid in NEFA, on bovine oviduct epithelial cells (OECs) during in vitro cell culture. METHOD OF STUDY: Bovine oviductal tissues ipsilateral to the corpus luteum were collected 1-3 days after ovulation; the OECs were isolated and cultured. RESULTS: PA increased lipid accumulation and activated caspase-3 in OECs, resulting in decreased cell proliferation. PA also stimulated the secretion of inflammatory cytokine interleukin (IL)-8 depending on TLR4, NF-κB activation, and reactive oxygen species (ROS) production...
February 10, 2017: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/28185362/definitive-class-i-human-leukocyte-antigen-expression-in-gestational-placentation-hla-f-hla-e-hla-c-and-hla-g-in-extravillous-trophoblast-invasion-on-placentation-pregnancy-and-parturition
#5
Rinat Hackmon, Lakmini Pinnaduwage, Jianhong Zhang, Stephen J Lye, Daniel E Geraghty, Caroline E Dunk
PROBLEM: The extravillous trophoblasts (EVT) express HLA-C and HLA-G, but HLA-E and HLA-F are the subject of conflicting reports. In this study, we define the HLA expression profile during active EVT placental implantation, pregnancy development, and parturition. METHOD OF STUDY: Immunohistochemistry, q-PCR, and Western blot were used to investigate HLA-C, HLA-E, and HLA-F placental expression across gestation from the early first trimester, late first trimester, second trimester (n=10 in each), preterm gestation (n=6) to elective term cesarean section and term vaginal deliveries (n=12, 38-41 weeks)...
February 10, 2017: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/28185353/human-vaginal-epithelial-cells-augment-autophagy-marker-genes-in-response-to-candida-albicans-infection
#6
Ankit Shroff, Roicy Sequeira, Kudumula Venkata Rami Reddy
PROBLEM: Autophagy plays an important role in clearance of intracellular pathogens. However, no information is available on its involvement in vaginal infections such as vulvo-vaginal candidiasis (VVC). VVC is intimately associated with the immune status of the human vaginal epithelial cells (VECs). The objective of our study is to decipher if autophagy process is involved during Candida albicans infection of VECs. METHODS OF STUDY: In this study, C. albicans infection system was established using human VEC line (VK2/E6E7)...
February 10, 2017: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/28185352/lnc-dc-mediates-the-over-maturation-of-decidual-dendritic-cells-and-induces-the-increase-in-th1-cells-in-preeclampsia
#7
Wen Zhang, Yang Zhou, YiLing Ding
PROBLEM: Preeclampsia is a severe pregnancy-related disease that involves an imbalance of the immune reaction, which is dominated by T helper1 (Th1) cells; however, the mechanism is unclear. METHOD OF STUDY: We used flow cytometry, RT-PCR and western blotting to detect Th1 cells in the blood and mature dendritic cells, lnc-DC (a long non-coding RNA that is specifically expressed in DCs and can mediate dendritic cell maturation by phosphorylating STAT3) and p-STAT3 (phosphorylated transducer and activator of transcription 3) in the deciduas of normal pregnancies and preeclampsia patients...
February 10, 2017: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/28185345/the-female-reproduction-and-senescence-nexus
#8
Cielo Mae D Marquez, Joyce A Ibana, Michael C Velarde
Successful pregnancy is regulated by several soluble factors that are differentially expressed throughout gestation. These factors are important to initiate and establish embryo implantation and parturition. Senescent cells, which undergo permanent cell proliferation arrest in response to stress, also produce several secreted factors, referred to as the senescence-associated secretory phenotype (SASP). Here, we review some of the secreted factors found during early and late pregnancy and compare their expression profile with those of the SASP...
February 10, 2017: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/28185343/birth-and-death-evidence-for-the-same-biologic-clock
#9
Mark Phillippe, Shiela M Phillippe
In mammals, there exists a strong correlation between the average life span (in years) and the length of gestation (in days), suggesting that the same biologic clock mechanisms control both of these physiologic events. Life span is determined by a complex sequence of events leading to organismal senescence, and ultimately death. Although multiple biochemical and cellular phenomena are believed to be involved, progressive telomere shortening due to oxidative stress and loss during DNA replication is believed to be an important determinant contributing to aging, senescence, and adult death...
February 10, 2017: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/28181345/in-vivo-and-in-vitro-experiments-before-new-direction-on-clinical-management-of-any-diseases-attributed-with-helicobacter-pylori
#10
LETTER
Amin Talebi Bezmin Abadi
No abstract text is available yet for this article.
February 9, 2017: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/28168784/platelet-derived-microparticles-and-soluble-factors-differentially-regulate-human-endometrial-epithelial-cell-movement
#11
Koh Suginami, Yukiyasu Sato, Akihito Horie, Hisanori Matsumoto, Hirohiko Tani, Yasunari Mizumoto, Masanori Ono, Ayumi Matsuoka, Satoru Kyo, Yoshihiko Araki, Ikuo Konishi, Hiroshi Fujiwara
PROBLEM: We previously proposed that platelets promote re-epithelialization during menstruation. As cell movement is one of the important cell behaviors in the process of tissue remodeling, we examined the effects of platelets on endometrial epithelial cell invasion. METHOD OF STUDY: The platelets were isolated from healthy women. Using a human endometrial epithelial cell-derived immortalized cell line, EM-E6/E7/hTERT cells, we examined the effects of platelets and platelet-derived condition media with or without microparticles on the morphological and invasive properties of EM-E6/E7/hTERT cells...
February 7, 2017: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/28158911/multiparity-upregulates-placental-plasminogen-and-urokinase-type-plasminogen-activator
#12
María E Cortina, Silvana Litwin, María R Rial Hawila, Silvia Miranda
PROBLEM: Multiparity increased the number of trophoblast cells in decidua of both low and high fetal loss mouse models. However, they differ in fetal survival rate and maternal thymocyte subpopulations, suggesting that trophoblast invasiveness is not equivalent. Our aim was to explore the involved mechanism. METHOD OF STUDY: We studied placentae from primiparous and multiparous females of low and high fetal loss models. We investigated invasiveness in vitro, expression of plasminogen, and its activators: tissue type (tPA)-urokinase type (uPA), and activity and expression of matrix metalloproteinases (MMP)-2 and MMP-9...
February 3, 2017: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/28138997/lipopolysaccharide-promotes-the-development-of-murine-endometriosis-like-lesions-via-the-nuclear-factor-kappa-b-pathway
#13
Yukihiro Azuma, Fuminori Taniguchi, Kazuomi Nakamura, Kei Nagira, Yin Mon Khine, Tomoiki Kiyama, Takashi Uegaki, Masao Izawa, Tasuku Harada
PROBLEM: Is lipopolysaccharide (LPS) involved in the development of endometriosis? METHOD OF STUDY: BALB/c mice (n=69) were used for the murine endometriosis model. Mice with surgically induced endometriosis were injected with LPS intraperitoneally. After 4 weeks of LPS injections with or without the nuclear factor-kappa B (NF-κB) inhibitor, the extent of endometriosis-like lesions was evaluated. Expression of inflammatory factors in the implants was evaluated using real-time RT-PCR...
January 31, 2017: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/28138995/time-course-analysis-of-rna-quality-in-placenta-preserved-by-rnalater-or-flash-freezing
#14
Nicole M Martin, Katherine M Cooke, Caitlin C Radford, Lauren E Perley, Michelle Silasi, Clare A Flannery
PROBLEM: Preservation of biospecimen quality is critical to accurately and reliably assessing genes and proteins. We evaluated the effect of preparation method and storage duration on RNA quality in placenta and decidua. METHOD OF STUDY: Aliquots of nine placentas and decidua were placed in RNAlater(®) (RL) or flash frozen (FF) within 30 minutes of delivery. RNA was extracted immediately (baseline) and from matched samples stored at -80°C for 1 and 8-10 months...
January 31, 2017: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/28132421/serologic-markers-of-autoimmunity-in-women-with-recurrent-pregnancy-loss
#15
Katrin Hefler-Frischmuth, Katharina Walch, Lukas Hefler, Clemens Tempfer, Christoph Grimm
PROBLEM: Various autoimmunologic mechanisms have been shown to be involved in recurrent pregnancy loss (RPL). This study aimed to evaluate whether women with RPL have elevated serum levels of common autoimmunologic parameters. METHOD OF STUDY: Serum levels of antinuclear antibodies (ANAs) were measured in 114 women with RPL, and 107 healthy controls using a qualitative immunometric enzyme immunoassay, serum levels of IgG class autoantibodies against histone, IgG class autoantibodies against nucleosomes, and IgG class autoantibodies against double-stranded (ds) DNA were measured by quantitative enzyme immunoassays...
January 29, 2017: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/28132398/modulation-of-antiphospholipid-antibodies-induced-trophoblast-damage-by-different-drugs-used-to-prevent-pregnancy-morbidity-associated-with-antiphospholipid-syndrome
#16
Angela M Alvarez, Norman Balcázar, Sebastián San Martín, Udo R Markert, Angela P Cadavid
PROBLEM: Women with antiphospholipid antibodies (aPLs) present a risk of pregnancy morbidity (PM), vascular thrombosis (VT), or both (PM/VT). aPLs affect trophoblast function, and the aim of this study was to determine the modulation of this aPL-induced damage by different drugs. METHOD OF STUDY: IgG was obtained from women with PM and PM/VT positive to aPLs. Binding of IgG to trophoblastic cells, proliferation, mitochondrial membrane integrity, and trophoblast invasion were assessed...
January 29, 2017: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/28120482/abnormal-peritoneal-regulation-of-chemokine-activation-the-role-of-il-8-in-pathogenesis-of-endometriosis
#17
Justyna Sikora, Marta Smycz-Kubańska, Aleksandra Mielczarek-Palacz, Zdzisława Kondera-Anasz
PROBLEM: Endometriosis is a chronic inflammatory disease associated with an impairment in immune response. Disorders in the peritoneal fluid and ectopic endometrium macrophage populations and their secretory products create a specific microenvironment inducing the development of the disease. The important factors involved in inflammation associated with endometriosis are chemokines, especially interleukin (IL)-8. For this reason, the current study briefly reviews the role of IL-8 in the pathogenesis of endometriosis...
January 25, 2017: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/28120470/hepatitis-b-virus-infection-status-and-infertility-causes-in-couples-seeking-fertility-treatment-indicator-of-impaired-immune-response
#18
Terence T Lao, Jennifer S M Mak, Tin-Chiu Li
PROBLEM: The relationship between hepatitis B (HBV) infection in infertile couples seeking in vitro fertilization (IVF) treatment and infertility causes is unknown. METHODS OF STUDY: A total of 831 infertile couples attending our unit seeking IVF during January to December 2015 were recruited. RESULTS: HBV infection was found in 6.3% and 7.3% of female and male partners, respectively, and infection in one or both partners was associated with less primary infertility (44...
January 25, 2017: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/28111861/comparison-of-sampling-methods-to-measure-hiv-rna-viral-load-in-female-genital-tract-secretions
#19
Shameem Z Jaumdally, Heidi E Jones, Donald R Hoover, Hoyam Gamieldien, Jean-Mari Kriek, Nontokozo Langwenya, Landon Myer, Jo-Ann S Passmore, Catherine S Todd
PROBLEM: How does menstrual cup (MC) compare to other genital sampling methods for HIV RNA recovery? METHOD OF STUDY: We compared HIV RNA levels between MC, endocervical swab (ECS), and ECS-enriched cervicovaginal lavage (eCVL) specimens in 51 HIV-positive, antiretroviral therapy-naive women at enrollment, 3 and 6 months, with order rotated by visit. Paired comparisons were analyzed with McNemar's exact tests, signed-rank tests, and an extension of Somer's D for pooled analyses across visits...
January 23, 2017: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/28054411/peach-gum-polysaccharides-improve-the-spermatogenesis-of-kkay-mice-with-impaired-reproduction-system
#20
Li Qian, Wenjun Wang, Jie Song, Dezhong Chen
PROBLEM: Peach gum polysaccharides (PGPs) exhibit antioxidant and antibacterial activities. Nevertheless, the effect of PGPs on the spermatogenesis of KKAy mice with impaired reproduction system remains undetermined. METHOD OF STUDY: PGPs were extracted with hot water. KKAy mice were randomly divided into two groups, namely, control and PGPs (treated with 100 mg/kg PGPs). RESULTS: Oral administration of PGPs decreased the levels of serum triglyceride, total cholesterol, low-density lipoprotein cholesterol, fasting blood glucose, plasma insulin, and nitrate nitrogen level in the testes of KKAy mice...
January 5, 2017: American Journal of Reproductive Immunology: AJRI
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