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Journal of Oral Pathology & Medicine

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https://www.readbyqxmd.com/read/28075506/efficacy-of-chlorhexidine-for-the-prevention-and-treatment-of-oral-mucositis-in-cancer-patients-a-systematic-review-with-meta-analyses
#1
REVIEW
Alvin Cardona, Amir Balouch, Moiz A Mohammed, Parish P Sedghizadeh, Reyes Enciso
BACKGROUND: Oral mucositis occurs in patients undergoing chemoradiation for cancer treatment. It is believed that colonization of ulcerated mucosa by bacteria, fungi and virus results in secondary infections. The effect of chlorhexidine (CHX) on the incidence and severity of oral mucositis in cancer patients was evaluated in this review. METHODS: Studies were limited to randomized placebo-controlled trials. Three databases were searched: MEDLINE (via PubMed), Web of Science and the Cochrane Library up to May 25, 2016...
January 11, 2017: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/28063153/volumetric-assessment-of-alveolar-clefts-a-literature-review
#2
REVIEW
João Batista Blessmann Weber, Luciane de Macedo Menezes, Fabiane Azeredo, Luciano Schwartz Lessa Filho
OBJECTIVE: To conduct a review of the literature on methods for volumetric assessment of alveolar clefts and ascertain which methods are most precise to guide future research. METHODS: The PubMed and MEDLINE databases were searched for English-language reports of clinical and in vitro studies with detailed descriptions of imaging modality, sample characteristics, and method for measurement of alveolar cleft volume. RESULTS: The search strategy yielded 34 articles, of which 14 were selected for in-depth analysis...
January 7, 2017: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/28054399/comparison-of-effects-of-zoledronic-acid-and-clodronate-on-the-bone-structure-imaginological-and-histomorphometrical-study-in-vivo
#3
Stephanie Joana Roman Martelli, Melissa Feres Damian, Ana Paula Neutzling Gomes, André Ribeiro Schinestsck, Alexandre Emídio Ribeiro Silva, Ana Carolina Uchoa Vasconcelos
OBJECTIVES: To compare histologically and imaginologically the bone structure of rats' mandibles treated with bisphosphonates (BPs) and rats that did not receive BPs. METHODS: Thirty-four rat specimens (Rattus novergicus, Wistar strain) were divided in 3 groups: (1) 12 rats treated with zoledronic acid; (2) 12 rats treated with clodronate; and (3) the control group, containing 10 rats that received saline solution. All individuals were exposed to cone beam computed tomography (CBCT)...
January 5, 2017: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/28054386/enzymatic-antioxidants-status-in-patients-with-recurrent-aphthous-stomatitis
#4
Zichuan Zhang, Shan Li, Huiqing Fang
BACKGROUND: Oxidative stress (OS) has been thought to play a main role in the etiopathogenesis of recurrent aphthous stomatitis (RAS), which is one of the most common oral mucosal diseases characterized by recurrent and painful oral ulcers. The aim of this investigation was to evaluate the enzymatic antioxidants status in patients with RAS in the active stage and remission stage. METHODS: Ninety seven patients with idiopathic minor RAS and 102 race, age and gender-matched healthy individuals were recruited...
January 5, 2017: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/28036153/semi-quantifiable-angiogenesis-parameters-in-association-with-the-malignant-transformation-of-oral-leukoplakia
#5
D Thiem, S Schneider, Narayan T V, V V Kumar, J Brieger, B Frerich, P W Kämmerer
BACKGROUND: Aim of the study was to assess the role of angiogenesis in the process of malignant transformation of clinical diagnosed oral leukoplakia (OL). MATERIALS AND METHODS: 131 histological preparations (oral leukoplakia/hyperkeratosis without dysplasia (OL; n=49), oral leukoplakia/hyperkeratosis with mild dysplasia (OL-SIN1; n=33), with moderate dysplasia (OL-SIN2; n=13) and leukoplakia-derived oral squamous cell carcinoma (OL-OSCC; n=36)) were evaluated for microvessel density (MVD), vessel diameter as well as for vascular endothelial growth factor (VEGF-A) expression...
December 30, 2016: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/28036101/cetuximab-sensitivity-of-head-and-neck-squamous-cell-carcinoma-xenografts-is-associated-with-treatment-induced-reduction-of-egfr-pegfr-and-psrc
#6
Adam Jedlinski, Stina Garvin, Ann-Charlotte Johansson, Per-Henrik Edqvist, Fredrik Ponten, Karin Roberg
BACKGROUND: The aims of this study were to validate in vitro drug sensitivity testing of head and neck squamous cell carcinoma (HNSCC) cell lines in an in vivo xenograft model and to identify treatment-induced changes in the epidermal growth factor receptor (EGFR) signaling pathway that could be used as markers for cetuximab treatment response. MATERIALS AND METHODS: The in vitro and in vivo cetuximab sensitivity of two HNSCC cell lines, UT-SCC-14 and UT-SCC-45, was assessed using a crystal violet assay and xenografts in nude mice, respectively...
December 30, 2016: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/28029690/myofibroblasts-could-be-recruited-in-a-chemokine-c-c-motif-ligand-2-dependant-manner-in-pathogenesis-of-oral-submucous-fibrosis
#7
Gargi Sarode, Sachin Sarode, Revati Deshmukh, Prashant Raktade, Shankargouda Patil
BACKGROUND: Monocyte chemoattractant protein-1 (CCL2) is a major profibrotic mediator with a proven role in fibrosis of different organs of the body. Recently, increased fibrosis in oral submucous fibrosis (OSMF) is linked with betel quid related chronic irritation and myofibroblast. Hence, this study is designed to investigate expression of CCL2 in OSMF and its correlation with myofibroblasts. MATERIALS AND METHODS: Paraffin-embedded specimens of 30 OSMF and 10 tissues of normal buccal mucosa were subjected to immunohistochemical analysis for CCL2 and alpha-smooth muscle actin (α-SMA) expression...
December 28, 2016: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/28027413/omega-3-a-novel-treatment-agent-in-oral-submucous-fibrosis-a-pilot-study
#8
Milanjeet Kaur Raizada, Digamber M Sable, Asha Chowdhery, Mahesh Shivaji Chavan, Ladu Singh Rajpurohit
BACKGROUND: Oral submucous fibrosis (OSF) is a chronic debilitating disease and a premalignant condition of the oral cavity. It is well known for its impervious nature to medical therapy. Omega 3 polyunsaturated fatty acids have been reported to have anti inflammatory properties. However, its role in OSF is still not known. This preliminary study assessed the efficacy of systemic omega 3 in this disease. METHODS: A randomized single blinded controlled trial was designed and a total of 10 clinically confirmed adult patients of OSF were included in the study...
December 27, 2016: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/28009451/sonic-hedgehog-is-present-in-parotid-saliva-and-is-decreased-in-patients-with-taste-dysfunction
#9
Robert I Henkin, Alexandra B Knöppel, Mona Abdelmeguid, William A Stateman, Suzanna Hosein
PURPOSE: To demonstrate that sonic hedgehog (Shh) is present in human parotid saliva and is decreased in human taste dysfunction. METHODS: Shh was measured in parotid saliva of 27 normal subjects and 81 patients with taste dysfunction of multiple etiologies by use of a sensitive spectrophotometric ELISA assay. Taste dysfunction was defined clinically by both subjective decreases of taste acuity and flavor perception and by impaired gustometry. RESULTS: Shh was found in parotid saliva in both normal subjects and in patients with taste dysfunction...
December 23, 2016: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/27977896/healing-acceleration-of-oral-mucositis-induced-by-5-fluorouracil-with-pistacia-atlantica-bene-essential-oil-in-hamsters
#10
Nader Tanideh, Mehdy Davarmanesh, Azadeh Andisheh-Tadbir, Zahra Ranjbar, Peiman Mehriar, Omid Koohi-Hosseinabadi
BACKGROUND: Oral mucositis is a common debilitating condition in cancer patients receiving cytotoxic therapies. The present study aimed to evaluate the effects of topical administrations of the essential oil extracted from hull of Pistaciaatlanticafruit (Bene) on healing of oral mucositis in golden hamsters. METHODS: Forty hamsters with oral mucositis induced by 5-Fluorouracil administered on days 0, 5 and 10 and buccal mucosal scratching were randomly divided into four equal groups; group 1 received no additional treatment, group 2 received gel base, groups 3 and 4 received gels containing 5 and 10% oilrespectively...
December 15, 2016: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/27977878/effects-of-potentially-functional-polymorphisms-in-suppressor-of-cytokine-signaling-3-socs3-on-the-risk-of-head-and-neck-squamous-cancer
#11
Dong Hang, Yin Yin, Lihua Wang, Hua Yuan, Jiangbo Du, Meng Zhu, Juncheng Dai, Ning Chen, Zhibin Hu, Hongbing Shen, Hongxia Ma
BACKGROUND: Suppressor of cytokine signaling 3 (SOCS3) has been identified as an inhibitor of JAK/STAT pathway that plays a significant role in carcinogenesis. SOCS3 and JAK2 polymorphisms may influence the gene expression or function, contributing to the disease susceptibility; however, such effect has not been evaluated in head and neck squamous cell carcinoma (HNSCC). METHODS: A case-control study was performed to test the associations of SOCS3 and JAK2 polymorphisms with risk of HNSCC in 576 cases and 1552 cancer-free controls from China...
December 15, 2016: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/27935126/does-cell-phone-use-increase-the-chances-of-parotid-gland-tumor-development-a-systematic-review-and-meta-analysis
#12
REVIEW
Elisa Carvalho de Siqueira, Fabrício Tinoco Alvim de Souza, Ricardo Santiago Gomez, Carolina Cavalieri Gomes, Renan Pedra de Souza
BACKGROUND: Prior epidemiological studies had examined the association between cell phone use and the development of tumors in the parotid glands. However there is no consensus about the question of whether cell phone use is associated with increased risk of tumors in the parotid glands. We performed a meta-analysis to evaluate the existing literature about the mean question and to determine their statistical significance. METHODS: Primary association studies. Papers that associated cell phone use and parotid gland tumors development were included, with no restrictions regarding publication date, language and place of publication...
December 9, 2016: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/27935125/clinical-phenotype-of-recurrent-aphthous-stomatitis-and-interleukin-1%C3%AE-genotype-in-a-polish-cohort-of-patients
#13
Zuzanna Ślebioda, Ewa Krawiecka, Marta Rozmiarek, Elżbieta Szponar, Anna Kowalska, Barbara Dorocka-Bobkowska
BACKGROUND: The aim of this study was to evaluate the relation between a clinical profile and the interleukin-1β (IL-1β) genotype in a Polish cohort of patients with RAS. METHODS: One hundred and four patients with RAS were enrolled in the study and all were subject to an oral examination. The severity of RAS was assessed according to the clinical type of the disease, the number of lesions per flare-up and the length of intervals between the episodes. The genotyping of two SNPs of the IL-1β gene, IL-1β c...
December 9, 2016: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/27935124/erythritol-chlorhexidine-combination-reduces-microbial-biofilm-and-prevents-its-formation-on-titanium-surfaces-in-vitro
#14
Lorenzo Drago, Monica Bortolin, Silvio Taschieri, Elena De Vecchi, Serse Agrappi, Massimo Del Fabbro, Luca Francetti, Roberto Mattina
BACKGROUND: The purpose of this in vitro study was to evaluate the antibiofilm activity of a novel air polishing powder consisting of erythritol and chlorhexidine, assessing its ability to reduce previously grown microbial biofilm and to prevent biofilm formation on titanium surfaces. METHODS: Clinical strains of Staphylococcus aureus, Pseudomonas aeruginosa, Bacteroides fragilis and Candida albicans isolated from peri-implantitis lesions were used. Biofilm was grown on sandblasted titanium discs and treated with erythritol/chlorhexidine...
December 9, 2016: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/27935123/efficacy-and-safety-of-nucleoside-antiviral-drugs-for-treatment-of-recurrent-herpes-labialis-a-systematic-review-and-meta-analysis
#15
REVIEW
Fangman Chen, Hao Xu, Jinli Liu, Yuan Cui, Xiaobo Luo, Yu Zhou, Qianming Chen, Lu Jiang
OBJECTIVES: To evaluate the effectiveness and safety of nucleoside antiviral drugs for the treatment of recurrent herpes labialis. METHODS: Randomized controlled trials that examined the effectiveness and/or safety of nucleoside antiviral drugs for recurrent herpes labialis were identified via a literature search. The parameters used to measure efficacy were time-to-healing of classic and all lesions, time-to-resolution of pain, and percentage of aborted lesions...
December 9, 2016: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/27935122/outcome-and-cervical-metastatic-spread-of-squamous-cell-cancer-of-the-buccal-mucosa-a-retrospective-analysis-of-the-past-25-years
#16
Keyvan Sagheb, Sebastian Blatt, Ina Sophie Kraft, Stefanie Zimmer, Roman-Kia Rahimi-Nedjat, Bilal Al-Nawas, Christian Walter
OBJECTIVES: Because of the low proportion of squamous cell carcinomas (SCC) of the buccal mucosa within the carcinomas of the oral cavity in the western population, data concerning metastatic pattern are sparse. Therefore, this retrospective study is focusing on the occurrence of cervical metastases (CM) and the overall outcome of this tumor entity. MATERIALS AND METHODS: From January 1988 to October 2013, 113 patients were treated in the Department of Oral and Maxillofacial Surgery Mainz for an oral SCC of the cheek...
December 9, 2016: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/27935119/differences-in-survival-outcome-between-oropharyngeal-and-oral-cavity-squamous-cell-carcinoma-in-relation-to-hpv-status
#17
Kenneth Lai, Murray Killingsworth, Slade Matthews, Nicole Caixeiro, Carlyn Evangelista, Xiao Wu, James Wykes, Alan Samakeh, Dion Forstner, Navin Niles, Angela Hong, Cheok Soon Lee
BACKGROUND: This study examined the prognostic significance of human papillomavirus (HPV) in patients with oropharyngeal and oral cavity squamous cell carcinoma (SCC). METHODS: Tissue microarrays were constructed from oropharyngeal and oral cavity SCC (n = 143). The presence of functional HPV in tumour was determined by combined assessments of p16 immunohistochemistry and HPV in situ hybridisation. RESULTS: Oropharyngeal SCC patients presented with more advanced disease in comparison with oral cavity SCC patients (P = 0...
December 9, 2016: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/27935117/long-noncoding-rna-malat1-affects-the-efficacy-of-radiotherapy-for-esophageal-squamous-cell-carcinoma-by-regulating-cks1-expression
#18
Zhijun Li, Yang Zhou, Bo Tu, Yu Bu, Aqiu Liu, Conghua Xie
OBJECTIVE: Long noncoding RNA MALAT1 has been well-studied in the progression of many malignancies. However, its association with the radioresistance of tumors has not been well-understood yet. This study tried to explore the role of MALAT1 in regulating the radiosensitivity of esophageal cancer (EC), especially esophageal squamous cell carcinoma (ESCC), involving its regulation on Cks1 expression. METHODS: KYSE150 cells were subcutaneously inoculated into nude mice to establish ESCC xenografts...
December 9, 2016: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/27935113/fak-is-overexpressed-in-keratocystic-odontogenic-tumor-a-preliminary-study
#19
Sachin C Sarode, Gargi S Sarode, Shakira Choudhary, Shankargouda Patil
BACKGROUND: Focal adhesion kinase (FAK) is an important mediator of cell adhesion, growth proliferation, survival, angiogenesis, and migration. FAK is over expressed in many locally invasive and malignant lesions including oral cancer. Looking at the tumorigenic nature of keratocystic odontogenic tumor (KCOT), which involves local invasion, proliferation, and recurrence, we hypothesized strong expression of FAK in the epithelial lining of KCOT. MATERIALS AND METHODS: 34 KCOTs, 11 orthokeratinized odontogenic cysts (OOCs), 25 radicular cysts (RCs), 17 dentigerous cysts (DCs) and 25 dental follicles (DFs) were retrieved from archives and subjected to the immunohistochemical analysis using FAK antibody...
December 9, 2016: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/27925697/prevalence-of-sj%C3%A3-gren-s-syndrome-in-brazilian-patients-infected-with-human-t-cell-lymphotropic-virus
#20
Daniela Assis do Vale, Jorge Casseb, Augusto César Penalva de Oliveira, Ivo Bussoloti Filho, Suzana Cantanhede Orsini Machado de Sousa, Karem López Ortega
BACKGROUND: Human T-lymphotropic virus type I (HTLV-I) is known to be associated with neoplastic and neurodegenerative changes, and it is believed to be associated with various systemic inflammatory diseases, including Sjögren's syndrome (SS). Although HTLV-I infection is endemic in Brazil, there is no information regarding the association between HTLV-I infection and SS in the Brazilian population. The objective of this study was to determine the prevalence of SS in HTLV-I-infected individuals and the prevalence of HTLV-I infection in individuals diagnosed with SS...
December 7, 2016: Journal of Oral Pathology & Medicine
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