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Journal of Oral Pathology & Medicine

Po-Yu Yang, Yi-Tzu Chen, Yu-Hsun Wang, Ni-Yu Su, Hui-Chieh Yu, Yu-Chao Chang
BACKGROUND: Oral submucous fibrosis (OSF) is a one of the well-recognized oral potentially malignant disorders. In this study, we investigated the malignant transformation of OSF in a Taiwanese population. METHODS: A retrospective cohort study was analyzed from Taiwan's National Health Insurance Research Database. A comparison cohort that was randomly frequency-matched with the OSF cohort according to age, sex, and index year. Oral leukoplakia (OL) was further stratified to evaluate for the possible synergistic effects for OSF-associated malignant transformation...
March 14, 2017: Journal of Oral Pathology & Medicine
Nikita Gulati, Devi Charan Shetty, Ajit Singh Rathore, Saurabh Juneja, Anshi Jain
BACKGROUND: Bcl-2 and E-cadherin proteins are known to be involved in the control of apoptotic cell death and invasive potential, respectively, which is an important hallmark of tumor regulation that influences their biologic behavior. AIM: The current study investigates the relationship of Bcl-2 and E-cadherin immunoexpression to histopathological and clinical prognostic factors in oral squamous cell carcinomas, and correlates E-cadherin/Bcl-2 ratio with Bryne's patterns of invasion...
March 14, 2017: Journal of Oral Pathology & Medicine
Harumi Mizuki, Ryosuke Abe, Shintaro Kogi, Toshinari Mikami
BACKGROUND: Oral lichen planus (OLP) is a T cell-mediated inflammatory disease; however, its exact etiology is unknown. Hyperkeratosis is often observed in OLP lesions. Previous studies have revealed the localization of Mycoplasma salivarium in the epithelial cells of oral leukoplakia with hyperkeratosis. Herein, we investigated the presence of M. salivarium in OLP tissue by immunohistochemistry to determine the causative factor of OLP. METHODS: Forty-one formalin-fixed, paraffin-embedded samples obtained from 31 patients with OLP were examined...
March 10, 2017: Journal of Oral Pathology & Medicine
Fabio Grizzi, Daniel Yiu, Sanja Stifter
The article by Dave et al. (1) aimed to correlate the expression of Mediator of DNA Damage Checkpoint Protein 1 (MDC1) with clinicopathological parameters and to evaluate its prognostic significance in 100 patients with oral squamous cell carcinoma (OSCC). Today, the main goal of oncological research remains the translation of newly discovered biochemical and histopathological biomarkers into clinical practice. Biomarkers can be mainly included in four classes: a) diagnostic biomarkers, b) prognostic biomarkers, c) predictive biomarkers, and d) surveillance biomarkers...
March 7, 2017: Journal of Oral Pathology & Medicine
Kyu-Young Oh, Kyoung-Ok Hong, Young-Sung Huh, Jae-Il Lee, Seong-Doo Hong
BACKGROUND: SOX7, a member of the SOX family of transcription factors, acts as a tumor suppressor in multiple cancers. Downregulation of SOX7 has been reported in advanced tumors and correlates with poor prognosis. The aims of this study were to investigate the effects of SOX7 on cell proliferation, invasion, and colony formation in oral squamous cell carcinoma (OSCC) cells and to evaluate the effectiveness of SOX7 protein as a prognostic indicator for OSCC patients. METHODS: OSCC cell lines were treated with SOX7 small interfering RNA or SOX7 peptide, and their effects on cell proliferation, invasiveness, and colony formation were investigated by proliferation, in vitro invasion, and clonogenic assays...
March 7, 2017: Journal of Oral Pathology & Medicine
Hellen Bandeira de Pontes Santos, Márcia Cristina da Costa Miguel, Leão Pereira Pinto, Manuel Antonio Gordón-Núñez, Pollianna Muniz Alves, Cassiano Francisco Weege Nonaka
BACKGROUND: Multinucleated giant cell (MGC) reactions have been identified in several malignancies, but their frequency and significance in lower lip squamous cell carcinoma (SCC) are not established. This study evaluated the MGC reactions and their association with clinicopathological parameters in lower lip SCCs. The polarization profile of these cells (M1 or M2 macrophages) was also assessed. METHODS: The presence and distribution of MGC reactions in high-power fields (400×) were evaluated in hematoxylin/eosin-stained histological sections of 91 lower lip SCCs...
February 15, 2017: Journal of Oral Pathology & Medicine
Branislav Ilic, Nadja Nikolic, Miroslav Andric, Drago Jelovac, Biljana Milicic, Tanja Jozic, Slobodan Krstic, Jelena Milasin
BACKGROUND: Polymorphisms in genes encoding tumor necrosis factor-α (TNF-α) and its receptor TNF-R1 have been shown to affect one person's susceptibility to develop certain neoplastic diseases. The aim of the present association study was to investigate whether single nucleotide polymorphisms (SNPs) in TNF-α (-308G>A) and TNF-R1 (36A>G) genes modulate the susceptibility for keratocystic odontogenic tumors (KCOTs) development in Serbian patients. METHODS: Genotyping was performed in 60 KCOT patients and 125 healthy individuals, using polymerase chain reaction/restriction fragment length polymorphism analysis...
February 15, 2017: Journal of Oral Pathology & Medicine
Zdeněk Daněk, Jan Gajdziok, Petr Doležel, Hana Landová, David Vetchý, Jan Štembírek
BACKGROUND: Buccal flexible films in the form of solid, thin, mucoadhesive patches can be used as dressings separating aphthous lesions from the environment of the oral cavity, which can in turn shorten the treatment period and reduce the pain perception. METHODS: The clinical study was performed on 36 volunteers suffering from aphthous lesions. The first group was treated using standard means-by application of an oral gel containing cholin salicylate (Mundisal) on the aphthous lesion...
February 15, 2017: Journal of Oral Pathology & Medicine
Liviu Feller, Razia A G Khammissa, Johan Lemmer
Chronic ulcerative stomatitis is an immune-mediated mucocutaneous disorder characterized clinically by erosions or ulcers. Most cases are limited to the mouth. The histopathological features are non-specific or mimic those of oral lichen planus, and studies by immunoflorescent microscopy are essential for definitive diagnosis. The defining immunopathogenic mechanism is the binding of IgG to the nuclear protein deltaNp63alpha of keratinocytes in the basal and parabasal cell layers of the oral stratified epithelium...
February 10, 2017: Journal of Oral Pathology & Medicine
Vineeta Singh, Nuzhat Husain, Naseem Akhtar, M Y Khan, Abhinav A Sonkar, Vijay Kumar
BACKGROUND: p16 overexpression and wild-type p53 expression is associated with human papilloma virus (HPV) in cervical and oropharyngeal cancer. Role of HPV-related carcinogenesis in the etiology of oral squamous cell carcinoma (OSCC) is still vague in Indian population. We aimed to explore the expression pattern of p16 and p53 in HPV positive and HPV negative OSCC to elicit differences, if any. Further their effect on survival of patients was studied. METHODS: Thirty-one consecutive HPV positive as well as 31 age and sex matched HPV negative OSCC cases from a case series of 369 histologically diagnosed cases of OSCC were included in this study...
February 10, 2017: Journal of Oral Pathology & Medicine
Mee-Young Ahn, Jung-Hoon Yoon
BACKGROUND: The overexpression of histone deacetylases (HDACs) has been observed in many cancers, and inhibition of specific HDACs has emerged as a new target for cancer therapy. We found that HDAC7 expression was selectively reduced by HDAC inhibitor apicidin in salivary mucoepidermoid carcinoma (MEC) cells. Here, we show that HDAC7 suppression has a potent antitumor effect in MEC cells. METHODS: Histone deacetylases7 was knocked down using HDAC7 siRNAs, and cell proliferation was quantified...
February 8, 2017: Journal of Oral Pathology & Medicine
S Singer, S R Zeissig, K Emrich, B Holleczek, K Kraywinkel, M Ressing
BACKGROUND: The objective of this study was to analyse the incidence of lip malignancies in Germany. METHODS: Data from population-based cancer registries covering a population of 39 million inhabitants from 14 federal states were pooled. Lip malignancies were classified according to the International Classification of Diseases (ICD-10). Age-standardised incidence rates and annual percentage changes in the incidence trends of lip cancer (C00), melanoma of the lip (C43...
February 8, 2017: Journal of Oral Pathology & Medicine
Vivian Petersen Wagner, Manoela Domingues Martins, Douglas Magno Guimaraes, Artur Cunha Vasconcelos, Luise Meurer, Pablo Agustin Vargas, Felipe Paiva Fonseca, Cristiane Helena Squarize, Rogerio Moraes Castilho
BACKGROUND: Epigenetic changes refer to any heritable modification in gene expression independent of alterations in the DNA sequence. Currently, it is well established that epigenetics represents a crucial player for tumor development. Nevertheless, the epigenetic mechanisms involved in the development and progression of salivary gland tumors (SGTs) remain poorly understood. METHODS: In the present study, we analyzed the pattern of acetyl-histone H3 (lys9) expression in benign and malignant SGTs and further correlate our results with tumors' proliferative activity and clinical outcomes...
February 4, 2017: Journal of Oral Pathology & Medicine
Jigna Harshadbhai Dave, Hemangini Hasit Vora, Nandita Radhabinod Ghosh, Trupti Indravadan Trivedi
BACKGROUND: The mediator of DNA damage checkpoint protein 1 (MDC1) is involved in the regulation of cell cycle check points and recruitment of several repair proteins to the site of DNA double stranded breaks (DSBs). The present study aims to correlate the expression of MDC1 protein with clinicopathological parameters and to evaluate its prognostic significance in patients with oral squamous cell carcinoma (OSCC). METHODS: MDC1 protein expression was evaluated immunohistochemically from untreated 100 patients with OSCC using modified H-score method...
February 4, 2017: Journal of Oral Pathology & Medicine
Ben Tudor-Green, Ricardo Gomez, Peter A Brennan
Head and neck soft tissue sarcomas are a group of rare heterogeneous tumours arising from embryonic mesoderm. They comprise less than 1% of all head and neck malignancies and 5-15% of all sarcomas with most head and neck sarcomas arising from soft tissues. Although rare, they are associated with both high recurrence and mortality rates. We review the current management of head and neck soft tissue sarcomas. This article is protected by copyright. All rights reserved.
January 31, 2017: Journal of Oral Pathology & Medicine
Jaroslav Valach, René Foltán, Marek Vlk, Pavol Szabo, Karel Smetana
BACKGROUND: Knowledge of the phenotypic pattern of oral squamous epithelium is important in the histopathologic evaluation of lesions including cancer. The literature on normal epithelium is controversial as the phenotype has not been evaluated in samples from completely healthy tissue donors without a history of tobacco and alcohol exposure. METHODS: In this study, we evaluated normal upper lip fornix and gingival mucosa from carefully selected young healthy donors without a history of smoking and alcohol exposure, and keratin types 8, 10, 14, and 17, filaggrin, and Ki67 were investigated in these donors...
January 31, 2017: Journal of Oral Pathology & Medicine
Ibtisam M Zargoun, L Bingle, P M Speight
BACKGROUND: Oral squamous cell carcinoma (OSCC) is the most frequently occurring malignant tumour in the oral cavity. OSCC arises because of multiple genetic alterations. Cell cycle aberrations and aneuploidy are reportedly among the main characteristics of cancer cells and are associated with aggressive growth and poor prognosis. METHODS: The study sample included 47 non-metastasised and 39 metastasised primary OSCC, with matched positive cervical lymph nodes and 17 normal oral mucosa samples...
January 30, 2017: Journal of Oral Pathology & Medicine
Amol Ramchandra Gadbail, Minal Chaudhary, Madhuri Gawande, Alka Hande, Sachin Sarode, Satyjit Ashok Tekade, Sheetal Korde, Prajakta Zade, Rahul Bhowate, Rajiv Borle, Swati Patil
BACKGROUND: The aim of this study was to compare the clinicopathological features of oral squamous cell carcinoma in the background of oral submucous fibrosis (OSCC-OSMF) and oral squamous cell carcinoma (OSCC). METHODS: 217 cases of OSCC were retrieved from achieves for the analysis.OSCC-OSMF cases were segregated on the basis of history and clinico-pathological parameters. RESULTS: The study included 217 patients of which 112 had OSCC and 105 OSCC-OSMF...
January 27, 2017: Journal of Oral Pathology & Medicine
Ya-Qin Tan, Qing Li, Jing Zhang, Ge-Fei Du, Rui Lu, Gang Zhou
BACKGROUND: CD4(+) T helper cell is crucial for the inflammatory autoimmune condition of oral lichen planus (OLP). Recently, the pathogenetic functions of T follicular helper (Tfh) cells, a subtype of CD4(+) T helper cells, has been revealed in autoimmune diseases for their pivotal regulation on humoral immunity. To explore the potential pathophysiological role of Tfh cells in OLP, the expression of circulating Tfh-like cells and its correlations with IL-21 and B cells were investigated...
January 25, 2017: Journal of Oral Pathology & Medicine
Allana Pivovar, Zilá Ferreira Dias Gonçalves Dos Santos, Cassius Carvalho Torres-Pereira
BACKGROUND: Oral squamous cell carcinoma (OSCC) is considered a major public health problem. The diagnosis often occurs in advanced stages, causing high morbidity and mortality and therefore prevention strategies should be advocated. This study aims to investigate a model of OSCC screening for high-risk individuals in the Family Health Strategy's (FHS) scenario. METHODS: Participants were men between 50 and 65 years of age registered in a primary health care electronic database and resident in an area with low socioeconomic status in the city of Curitiba (Paraná/Brazil)...
January 25, 2017: Journal of Oral Pathology & Medicine
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