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Journal of Oral Pathology & Medicine

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https://www.readbyqxmd.com/read/28520088/clathrin-mediated-endocytosis-is-required-for-ane-30-100k-induced-autophagy
#1
Mei-Huei Lin, Young-Chau Liu, Shyun-Yeu Liu, Fang-Chi Chen, Pei-Jung Yang, Guan-Hua Li, Pang-Yen Liu, Ching-Yu Yen
BACKGROUND: We identified an autophagy-inducing areca nut (AN) ingredient (AIAI) in the 30-100 kDa fraction of AN extract (ANE 30-100K). This study was to analyze the role of endocytosis in ANE 30-100K-induced autophagy. METHODS: We used benzyl alcohol, dynasore, and shRNA of clathrin and dynamin to assess whether ANE 30-100K-induced cytotoxicity and accumulation of microtubule-associated protein 1 light chain 3 (LC3)-II were affected in oral (OECM-1) and esophageal (CE81T/VGH) carcinoma cells...
May 18, 2017: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/28512746/a-panel-of-micrornas-can-be-used-to-determine-oral-squamous-cell-carcinoma
#2
Gareema Prasad, Christine Seers, Eric Reynolds, Michael J McCullough
BACKGROUND: Subjective histopathology is currently used to diagnose oral squamous cell carcinoma (OSCC). We tested if abundances of a panel of microRNA could be an objective OSCC indicator. METHOD: Literature review enabled identification of 10 microRNAs associated with oral and head and neck malignancies. We extracted RNA from formalin-fixed paraffin embedded biopsies; 20 each with OSCC, dysplasia or histologically normal epithelium (HNE) and 10 with oral lichen planus (OLP)...
May 17, 2017: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/28494124/professor-crispian-scully-cbe-dsc-dchd-dmed-hc-dhc-multi-md-phd-phd-hc-fmedsci-mds-mrcs-bsc-fdsrcs-fdsrcps-ffdrcsi-fdsrcsed-frcpath-fhea-1945-2017
#3
Marco Carrozzo
No abstract text is available yet for this article.
May 11, 2017: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/28489259/molecular-alterations-in-odontogenic-keratocysts-as-potential-therapeutic-targets
#4
REVIEW
Carolina Cavalieri Gomes, Letícia Martins Guimarães, Marina Gonçalves Diniz, Ricardo Santiago Gomez
The odontogenic keratocyst (OKC) is a cystic lesion, lined by uniformly-thickened parakeratinized epithelium. Some lesions are large and tend to recur after surgical treatment. The neoplastic nature of OKCs remains a matter of dispute. It is known that some sporadic OKCs harbor PTCH1 mutations, and via the dissection of cyst epithelium, these mutations were demonstrated to occur much more frequently than previously thought. In addition to the classical PTCH1 mutations, Hedgehog pathway disturbance and Bcl-2 protein overexpression, as detected via genome-wide expression analysis of OKCs, have been published...
May 10, 2017: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/28477349/cytological-and-cytomorphometric-evaluation-of-the-oral-mucosa-in-hiv-infected-patients-undergoing-antiretroviral-therapy
#5
Mônica Ghislaine Oliveira Alves, Celina Faig Lima Carta, Adriana Aigotti Haberbeck Brandão, Juvencio José Duailibe Furtado, Marcelo Marcucci, Janete Dias Almeida
BACKGROUND: To evaluate HIV infection-induced alterations in the oral mucosa by comparing inflammation, cell maturation and cytomorphometric changes in oral mucosal cells between HIV-infected patients undergoing highly active antiretroviral therapy (HAART) and non-HIV-infected patients. \ METHODS: Thirty HIV-infected patients undergoing HAART and 30 non-HIV-infected patients were studied. Four smears were obtained from the lateral border of the tongue and floor of the mouth with a cytobrush...
May 6, 2017: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/28477348/the-potential-role-of-in-vivo-optical-coherence-tomography-for-evaluating-oral-soft-tissue-a-systematic-review
#6
REVIEW
Enrica Gentile, Claudio Maio, Antonio Romano, Luigi Laino, Alberta Lucchese
BACKGROUND: The introduction of optical coherence tomography (OCT) in dentistry enabled the integration of already existing clinical and laboratory investigations in the study the oral cavity. This systematic review, presents an overview of the literature, to evaluate the usefulness of in vivo OCT for diagnosing oral soft tissues lesions, to compare the OCT results with traditional histology, and to identify limitations in prior studies so as to improve OCT applications. METHODS: We performed a review of the literature using different search engines (PubMed, ISI Web of Science, and the Cochrane Library) employing MeSH terms such as "optical coherence tomography" and "OCT" in conjunction with other terms...
May 6, 2017: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/28463405/studying-the-association-between-methylene-tetrahdrofolate-reductase-mthfr-677-gene-polymorphism-cardiovascular-risk-and-lichen-planus
#7
Laila Rashed, Rania Abdel Hay, Marwa AlKaffas, Shereen Ali, Dina Kadry, Sara Abdallah
BACKGROUND: There is a reported relation between hyperhomocysteinemia and lichen planus (LP). An increase in homocysteine (Hcy) and the risk of cardiovascular disease (CVD) in patients with methylenetetrahydrofolate reductase (MTHFR) mutation has been described OBJECTIVE: To detect MTHFR (C677T) gene polymorphism, and to find its association with CVD risk, Hcy and folic acid levels in patients with LP METHODS: This hospital-based case-control study included 110 patients with LP; 70 with cutaneous LP (CLP) and 40 with oral LP (OLP)...
April 30, 2017: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/28437013/the-prognostic-value-of-b7-h6-protein-expression-in-human-oral-squamous-cell-carcinoma
#8
Jiongke Wang, Xin Jin, Jiajia Liu, Kui Zhao, Hao Xu, Jing Wen, Lu Jiang, Xin Zeng, Jing Li, Qianming Chen
OBJECTIVES: To investigate the expression and prognostic value of B7-H6 protein in oral squamous cell carcinoma tissues. MATERIALS AND METHODS: A total of 50 oral squamous cell carcinoma samples, 10 oral leukoplakia samples and 17 normal controls were included in the analysis. The expression of B7-H6 in oral squamous cell carcinoma, oral leukoplakia and normal controls was evaluated by immunohistochemical assay. RESULTS: The B7-H6 protein expression was significantly higher in oral squamous cell carcinoma tissues than that in normal oral mucosa...
April 24, 2017: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/28437012/leptin-and-ngf-in-saliva-of-patients-with-diabetes-mellitus-type-2-a-pilot-study
#9
Tvarijonaviciute Asta, Candela Castillo, Jose J Ceron, Silvia Martinez-Subiela, Fernando Tecles, Pia López-Jornet
AIMS: This study aimed to measure salivary levels of leptin and NGF in patients with type 2 diabetes (T2D) and to compare with healthy subjects. In addition, markers previously evaluated in diabetes, including insulin, HGF and MCP-1, and markers of inflammation (IL-1b, IL-6, IL-8, TNF-α), were also measured in saliva in order to evaluate possible relationship of these markers with the new analytes evaluated in the study. METHODS: Unstimulated whole saliva was collected by passive drooling from a total of 65 individuals (34 controls and 31 with T2D) and used for leptin, NGF, HGF, MCP-1, insulin, IL-1b, IL-6, IL-8, and TNF-α determination...
April 24, 2017: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/28425129/role-of-sialyl-6-sulfo-lewis-x-in-antitumor-immunity-against-oral-squamous-cell-carcinoma
#10
Hisato Yoshida, Hitomi Hoshino, Yoshiaki Imamura, Hitoshi Yoshimura, Kazuo Sano, Motohiro Kobayashi
BACKGROUND: Tumor-infiltrating lymphocytes (TILs) reportedly play a pivotal role in antitumor immunity against oral squamous cell carcinoma (OSCC); however, mechanisms governing TIL recruitment to OSCC tissues remain to be clarified. This study was undertaken to assess a potential association between TILs and high endothelial venule (HEV)-like vessels that express sialyl 6-sulfo Lewis X (LeX). METHODS: OSCC tissue sections (n=41) were subjected to immunohistochemistry for sialyl 6-sulfo LeX and CD34 to allow quantitation of HEV-like vessels...
April 20, 2017: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/28393404/patients-with-high-c-myc-expressing-squamous-cell-carcinomas-of-the-tongue-show-better-survival-than-those-with-low-and-medium-expressing-tumours
#11
Klas Strindlund, Giuseppe Troiano, Nicola Sgaramella, Philip J Coates, Xiaolian Gu, Linda Boldrup, Luigi Califano, Robin Fahraeus, Lorenzo Lo Muzio, Fatima Ardito, Giuseppe Colella, Gianpaolo Tartaro, Renato Franco, Lena Norberg-Spaak, Mohammad Saadat, Karin Nylander
BACKGROUND: c-MYC is a potent oncoprotein with roles in a wide range of cellular processes such as differentiation, apoptosis and growth control. Deregulation of the MYC gene is commonly seen in human tumours resulting in overexpression of the protein. Here we studied expression of c-MYC in correlation to clinical outcome in patients with primary squamous cell carcinoma of the mobile tongue. METHODS: Immunohistochemistry was used to identify c-MYC in a group of 104 tongue squamous cell carcinomas with an antibody directed against the N-terminal part of the protein...
April 10, 2017: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/28391621/oral-submucous-fibrosis-an-update-on-pathophysiology-of-malignant-transformation
#12
REVIEW
Gururaj Arakeri, Shekar Gowda Patil, Abdulsalam S Aljabab, Kuan-Chou Lin, M A W Merkx, Shan Gao, Peter A Brennan
Oral submucous fibrosis (OSMF) is a potentially malignant condition associated with areca nut chewing. Formerly confined to the Indian subcontinent, it is now often seen in Asian populations of the United Kingdom, USA and other developed countries, and is therefore a serious problem for global health. What makes it more sinister is the malignant transformation rate, which has been reported to be around 7.6% over a 17-year period. In this concise article, we review the current trends in the pathophysiology of malignant transformation of OSMF...
April 9, 2017: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/28391620/oral-submucous-fibrosis-an-update-on-current-theories-of-pathogenesis
#13
REVIEW
Gururaj Arakeri, Kirthi Kumar Rai, Santosh Hunasgi, M A W Merkx, Shan Gao, Peter A Brennan
Over the last 40 years, many theories linking oral submucous fibrosis (OSMF) to various risk factors have been proposed. Spicy, pungent foods and irritants such as supari (areca nut), paan (betel leaves), tobacco (through chewing or smoking)-the common Asian habits of chewing the aforementioned agents-have all been incriminated as causative agents. Systemic factors such as nutritional deficiency, genetic predisposition and autoimmunity have also been proposed in the pathogenesis of OSMF. However, the precise aetiology of OSMF is still unknown, and no conclusive evidence has been found despite many extensive investigations on implicated factors...
April 9, 2017: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/28391602/current-protocols-in-the-management-of-oral-submucous-fibrosis-an-update
#14
REVIEW
Gururaj Arakeri, Kirthi Kumar Rai, George Boraks, Shekar Gowda Patil, Abdulsalam S Aljabab, M A W Merkx, Marco Carrozzo, Peter A Brennan
Oral submucous fibrosis (OSMF) is a debilitating condition of oral cavity which has significant potential for malignant transformation. In spite of over 20 years of research, the pathogenesis of the condition is still obscure and no single management modality is effective. Many OSMF treatment protocols have been proposed to alleviate the signs and symptoms of the disorder and there is overwhelming evidence that as areca nut is primary cause, stopping its use may have a considerable effect on symptoms rather than reversing pre-existing fibrosis...
April 9, 2017: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/28390063/psychological-profiles-in-patients-with-symptomatic-reticular-forms-of-oral-lichen-planus-a-prospective-cohort-study
#15
Daniela Adamo, Marco Cascone, Antonio Celentano, E Ruoppo, Stefania Leuci, Massimo Aria, Michele D Mignogna
OBJECTIVES: To analyze intra, extra-oral symptoms and psychological profiles in symptomatic patients with reticular (R) forms of oral lichen planus (OLP). MATERIALS AND METHODS: Thirty symptomatic R-OLP (sR-OLP) patients were compared with an equal number of non-symptomatic R-OLP (nsR-OLP) patients, burning mouth syndrome (BMS) patients and healthy subjects (HS). The Numeric Rating Scale (NRS), the Total Pain Rating Index (T-PRI) and the Hamilton Rating Scales for Depression (HAM-D) and Anxiety (HAM-A) were administered...
April 8, 2017: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/28383823/reproducibility-repeatability-and-level-of-difficulty-of-two-methods-for-tumor-budding-evaluation-in-oral-squamous-cell-carcinoma
#16
Priscila Laiza Rubim Leão, Helvécio Marangon Junior, Victória Vasconcellos Moreira Melo, Ângela Braga Caixeta, Paulo Eduardo Alencar Souza, Maria Cássia Ferreira de Aguiar, Martinho Campolina Rebello Horta
BACKGROUND: This study aimed to analyze the reproducibility, repeatability and level of difficulty of two methods for tumor budding evaluation in oral squamous cell carcinoma (OSCC): staining by hematoxylin and eosin (HE), and immunostaining for multi-cytokeratin. METHODS: The evaluation of tumor budding was performed by three examiners in 103 samples of OSCC, using the two methods. A Likert-type scale was used to measure the difficulty in the assessment. The inter-examiner agreement (reproducibility) was estimated using Fleiss's Kappa and the intra-examiner agreement (repeatability) was estimated using Cohen's Kappa...
April 6, 2017: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/28383762/deficient-double-strand-break-repair-in-oral-squamous-cell-carcinoma-cell-lines
#17
Maryam Jessri, Andrew J Dalley, Camile S Farah
BACKGROUND: Approximately 20% of oral squamous cell carcinoma (OSCC) cases arise without any identifiable environmental cause, suggesting involvement of genetic influences in their aetiology. DNA double-strand breaks (DSBs) sever both strands of DNA and pose a potential threat to genomic integrity. A hastened accumulation of somatic mutations consequent to DSB repair is deemed to be a likely event in tumorigenesis of OSCC. METHODS: Two discrete chemical approaches, namely hydrogen peroxide and camptothecin, were used to induce DSB in oral cell lines derived from normal through dysplastic to OSCC tissues...
April 6, 2017: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/28370402/immunophenotype-of-neutrophils-in-oral-squamous-cell-carcinoma-patients
#18
Patrícia Carlos Caldeira, Érica Leandro Marciano Vieira, Alexandre Andrade Sousa, Antônio Lúcio Teixeira, Maria Cássia Ferreira Aguiar
BACKGROUND: The aim was to explore the immunophenotype of neutrophils and lymphocytes and the inflammatory mediators in patients with oral squamous cell carcinoma, comparing with controls; and to associate with clinicopathological data. METHODS: Blood was collected from 13 patients and 13 controls. The immunophenotype of neutrophils (CD66b, CD16, CD11a, arginase-1), T lymphocytes (CD4, CD8) and the intracellular cytokine production (IL-10, TNF, IFN-γ) was evaluated by flow cytometry...
March 29, 2017: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/28370338/angiopoietin-2-is-expressed-in-oral-kaposi-s-sarcoma
#19
Antonio Rossi, Leticia Ferreira, Maria Cuevas-Nunez, John M Wright, Alfredo M De-Paula, John R Basile, Bruno C Jham
Kaposi's sarcoma (KS) persists today as a highly prevalent vascular cancer, often found in HIV patients. Studies have shown that angiopoietin 2 (Ang2), a pro-angiogenic protein, is involved in the pathogenesis of this tumor. However, expression of this protein has not been investigated in oral KS lesions. Thus, we aimed to investigate the expression of Ang2 in samples of oral KS METHODS: Immunohistochemistry was used to evaluate Ang2 expression in 14 oral KS cases, with degrees of expression being analyzed in a semi-quantitative manner...
March 29, 2017: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/28342264/pdgfra-mrna-is-overexpressed-in-oral-cancer-patients-as-compared-to-normal-subjects-with-a-significant-trend-of-overexpression-among-tobacco-users
#20
Hui Shan Ong, Sandhya Gokavarapu, Zhen Tian, Jiang Li, Qin Xu, Wei Cao, Chen Ping Zhang
BACKGROUND: Platelet-derived growth factors alpha (PDGFA) is a tyrosine kinase receptor activator which is known to be amplified in the malignancies, and their expression levels are correlated to tumor progression and reduced overall survival. The expression of PDGFRA is different among the tumors and normal tissues; furthermore, their expression level is site specific. Under a physiological condition, PDGFRA and its ligand are expressed in distinct cell populations and activated in a paracrine manner...
March 25, 2017: Journal of Oral Pathology & Medicine
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