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Journal of Oral Pathology & Medicine

Simon A Fox, Sean S Currie, Andrew J Dalley, Camile S Farah
BACKGROUND: The role of alcohol-containing mouthwash as a risk factor for the development of oral cancer is a subject of conflicting epidemiological evidence in the literature despite alcohol being a recognised carcinogen. The aim of this study was to use in vitro models to investigate mechanistic and global gene expression effects of exposure to alcohol-containing mouthwash. METHODS: Two brands of alcohol-containing mouthwash and their alcohol-free counterparts were used to treat two oral cell lines derived from normal (OKF6-TERT) and dysplastic (DOK) tissues...
March 5, 2018: Journal of Oral Pathology & Medicine
Divya Gopinath, Rohit Kunnath Menon
We read with great interest the article titled "The role of human papillomavirus in p16-positive oral cancers" by Belobrov et al. [1]. We appreciate the author's efforts on their interesting contribution to the complex paradigm of Human papillomavirus (HPV) detection which has been prevalent in literature for a long time. We would like to further emphasize the importance of their findings with reference to two aspects. This article is protected by copyright. All rights reserved.
March 2, 2018: Journal of Oral Pathology & Medicine
Zuzanna Ślebioda, Ewa Krawiecka, Elżbieta Szponar, Barbara Dorocka-Bobkowska
BACKGROUND: RAS is a common ulcerative disorder of the oral mucosa, where the immune impairment may develop in genetically predisposed subjects exposed to certain environmental factors. The aim of the study was to investigate the frequency of anaemia, iron and vitamin B12 deficiency in RAS and to explore its impact on the clinical presentation of RAS. METHODS: A total of 141 adults including: 71 subjects with RAS and 70 controls were enrolled in the study. A detailed dental and haematological assessment, including full blood count, serum iron and vitamin B12 evaluation was performed in all study participants...
March 2, 2018: Journal of Oral Pathology & Medicine
Veruska Lima Moura Brasil, Mariana Bitu Ramos Pinto, Roberta Ferreti Bonan, Luiz Paulo Kowalski, Danyel Elias da Cruz Perez
Humans may be exposed to pesticides such as fungicides, herbicides and insecticides, during occupational and non-occupational activities. Pesticides could be related to cancer development mainly because of their effects on the endocrine and immune systems and their cumulative effect. The present review evaluated in current literature evidence of an association between exposure to pesticides and the occurrence of head and neck cancer (HNC). A literature search for cohort studies was conducted in the PubMed, Web of science and Cochrane databases...
February 28, 2018: Journal of Oral Pathology & Medicine
Sachin C Sarode, Minal Chaudhary, Amol Gadbail, Satyajit Tekade, Shankargouda Patil, Gargi S Sarode
BACKGROUND: The grading of oral epithelial dysplasia (OED) is not applicable to oral submucous fibrosis (OSMF) cases due to the presence of atrophic epithelium. The mucosal margins associated with resected OSCC specimens are often closely related to transformed cells. In this study, we compared the histomorphological alterations (dysplastic features) in the atrophic epithelium of OSMF patients with the mucosal margins of OSCC associated with OSMF (OSCC-OSMF). METHODS: We evaluated 17 dysplastic features in 37 patients with OSMF (biopsy site: buccal mucosa) and 37 patients with OSCC-OSMF (mucosal margins involving buccal mucosa) using histopathological staining...
February 25, 2018: Journal of Oral Pathology & Medicine
Gururaj Arakeri, Peter A Brennan
Dr Rai states that the burning sensation has only been included in the F1 category when it is present in both early and advanced cases, and therefore suggests including it in all the stages. There is evidence in the literature that the burning sensation is a specific parameter of onset of OSMF.2, 3 However, its significance as an indicator of severity of fibrosis is not well established since advanced fibrosis and the associate trismus restrict dietary intake and patients may avoid any food which causes burning mucosa...
February 23, 2018: Journal of Oral Pathology & Medicine
Chen Zhou, Yaping Wu, Lei Jiang, Zhongwu Li, Pengfei Diao, Dongmiao Wang, Wei Zhang, Laikui Liu, Yanling Wang, Hongbing Jiang, Jie Cheng, Jianrong Yang
BACKGROUND: Tumor-infiltrating lymphocytes (TILs) are regarded as adaptive immune response of the host to cancer cells and valuable prognostic factors. Here, we sought to characterize the densities and locations of CD3+ and CD8+ TILs in primary oral squamous cell carcinoma (OSCC) samples and assess their clinicopathological and prognostic significance. METHODS: A total number of 169 OSCC samples from two independent patient cohorts (Nanjing cohort, 93 cases; Wuxi cohort, 76 cases) were retrospectively collected...
February 22, 2018: Journal of Oral Pathology & Medicine
Arpita Rai
The article tilted - TFM classification and Staging of oral submucous fibrosis: A new proposal, authored by Arakeri et al was an interesting read. The authors have reviewed the current grading and staging schemes for oral submucous fibrosis (OSMF) and evaluated the clinicopathological classification system proposed by Khanna and Andrade for agreement and correlation I congratulate the authors for proposing a very comprehensive, treatment-oriented classification and staging system for OSMF. This article is protected by copyright...
February 22, 2018: Journal of Oral Pathology & Medicine
Java Walladbegi, Sarah A Smith, Amy Grayson, Craig Murdoch, Mats Jontell, Helen E Colley
BACKGROUND: The cytotoxic effect of chemotherapeutic agents to the oral mucosa, as a side-effect of cancer treatment, is a major problem. Cooling the oral mucosa using ice chips in conjunction with chemotherapy is known to reduce the severity of oral mucositis. However, although the use of ice chips is of clinical value, this method of cooling has inherent problems including discomfort for the patient, non-uniformity and fluctuations in cooling temperature throughout the oral cavity. Furthermore, despite being used clinically, it is not known what reduction in temperature is required to prevent oral mucositis...
February 22, 2018: Journal of Oral Pathology & Medicine
Felipe Paiva Fonseca, Bernar Monteiro Benites, Ciro Dantas Soares, Thayná Melo de Lima Morais, Gleyson Kleber do Amaral-Silva, Oslei Paes de Almeida, Fernando Augusto Soares, Eduardo Rodrigues Fregnani
BACKGROUND: Fibroblast growth factor 2 (FGF2) and FGF receptor 1 (FGFR1) have been investigated in different human neoplasms and were shown to play important roles in the pathogenesis of these diseases; however, very few is known regarding their prognostic importance in the context of ameloblastoma. Therefore, the aim of this study is to investigate if the expression of FGF2 and FGFR1 is associated with ameloblastoma clinical behavior. METHODS: Fifty-eight cases of ameloblastoma arranged in tissue microarray were submitted to immunohistochemistry against FGF2 and FGFR1...
February 17, 2018: Journal of Oral Pathology & Medicine
Alison Barry, Ken D O'Halloran, Joseph P McKenna, Christine McCreary, Brendan Harhen, Daniel M Kerr, David P Finn, Eric J Downer
OBJECTIVE: The objective was to measure endocannabinoid (eCB) ligands and non-cannabinoid N-acylethanolamine (NAE) molecules in plasma from individuals with burning mouth syndrome (BMS), and to determine if plasma eCB/NAE levels correlated with pain, inflammation and depressive symptomatology in this cohort. STUDY DESIGN: Plasma content of the eCBs, anandamide (AEA) and 2-arachidonoyl-glycerol (2-AG), and the NAE molecules, palmitoylethanolamide (PEA) and oleolylethanolamide (OEA), were assessed in healthy subjects (n=8) and in a cohort of newly diagnosed BMS patients (n=9) using liquid chromatography-tandem mass spectrometry...
February 13, 2018: Journal of Oral Pathology & Medicine
Simona Slezakova, Petra Borilova Linhartova, Lucie Masopustova, Jirina Bartova, Jitka Petanova, Pavel Kuklinek, Antonin Fassmann, Ladislav Dusek, Lydie Izakovicova Holla
BACKGROUND: Recurrent aphthous stomatitis (RAS) is a multifactorial disease with unclear etiopathogenesis in which disturbance of immunological processes may be involved. The aim of our study was to investigate three single nucleotide polymorphisms (SNPs) rs3806265, rs4612666, rs10754558 in NOD-like receptor 3 (NLRP3), the gene encoding the component of inflammasome, in patients with RAS and healthy controls in the Czech population. METHODS: A total of 207 subjects were included in this case-control study...
February 12, 2018: Journal of Oral Pathology & Medicine
Hongchuang Zhang, Gang Li, Zaiou Zhu, Yang Zheng, Yunong Wu, Wei Zhang, Ning Gu, Xiang Wang, Xiaomeng Song
BACKGROUND: Aberrant level of serum bilirubin, marker of hepatobiliary and hematological disorders, was associated with patient prognosis in several human malignances. In the present study, we aim to evaluate the predictive value of serum bilirubin for clinicopathologic characteristics and survival of patients with oral squamous cell carcinoma (OSCC). METHODS: This study retrospectively reviewed 129 patients with OSCC and 129 normal controls matched for age and sex...
February 11, 2018: Journal of Oral Pathology & Medicine
Hui Wang, Xiaobing Guan, Zhenhua Luo, Yao Liu, Qian Ren, Xin Zhao
BACKGROUND: The present study was to investigate association and potentially destructive role of Th9/IL-9 and their synergistic interaction with Th17 cells in elevating MMP9 production in local lesions of oral lichen planus (OLP) patients. METHODS: Oral mucosal tissues were obtained from OLP patients and healthy controls (HC) and then divided into an epithelial part (EP) or a lamina propria part (LP). Both EP and LP subsets were assessed for IL-9 and MMP9 mRNA levels by real-time quantitative PCR (qPCR)...
February 7, 2018: Journal of Oral Pathology & Medicine
Yue Wang, Pengfei Wang, Oleh Andrukhov, Tingjian Wang, Siying Song, Changxiang Yan, Fengqiu Zhang
BACKGROUND: A number of studies have assessed the prognostic value of the neutrophil-to-lymphocyte ratio (NLR) in oral squamous cell carcinoma (OSCC), but their results regarding the predictive value of NLR in OSCC are inconsistent. We therefore performed a meta-analysis to clarify the association between NLR and clinical outcome in OSCC. METHODS: We searched the MEDLINE and Web of Science to identify potential studies investigating the association between NLR and survival in OSCC...
February 6, 2018: Journal of Oral Pathology & Medicine
Gururaj Arakeri, Deepak Thomas, Abdulsalam S Aljabab, Santosh Hunasgi, Kirthi Kumar Rai, Beverley Hale, Felipe Paiva Fonseca, Ricardo Santiago Gomez, Siavash Rahimi, M A W Merkx, Peter A Brennan
BACKGROUND: We have evaluated the rationale of existing grading and staging schemes of oral submucous fibrosis (OSMF) based on how they are categorized. A novel classification and staging scheme is proposed. METHODS: 300 OSMF patients were evaluated for agreement between functional, clinical and histopathological staging. Bilateral biopsies were assessed in 25 patients to evaluate for any differences in histopathological staging of OSMF in the same mouth. Extent of clinician agreement for categorized staging data was evaluated using Cohen's weighted Kappa analysis...
February 5, 2018: Journal of Oral Pathology & Medicine
Hong Sheng, Toru Ogawa, Yoshimi Niwano, Keiichi Sasaki, Katsuro Tachibana
BACKGROUND: Normal human oral keratinocytes are highly sensitive to anticancer drugs including doxorubicin. Resveratrol, epigallocatechin gallate and tannic acid are polyphenolic compounds were reported to have cardioprotective effect when combined with doxorubicin. However, it is unknown whether these polyphenols could protect normal human oral keratinocytes against doxorubicin-induced cytotoxicity without weakening its cytotoxic potential against oral cancer cells. Here, we examined the effects of the three polyphenolic compounds on doxorubicin-induced cytotoxicity in normal human oral keratinocytes and also investigated their effects on doxorubicin potency in HSC-2 human oral squamous cell carcinoma cells...
January 30, 2018: Journal of Oral Pathology & Medicine
Itzel Castillejos-García, Velia Ramírez-Amador, Adela Carrillo-García, Alejandro García-Carrancá, Marcela Lizano, Gabriela Anaya-Saavedra
BACKGROUND: Oral high-risk human papillomavirus (HR-HPV) infections are frequent and persistent among HIV-positive population and are associated with an increased risk for head and neck cancer (HNC). In this study, we sought to determine the incidence, persistence, and clearance of HPV-infections in oral and oropharyngeal samples from HIV/AIDS subjects. METHODS: A longitudinal, observational, and analytical study was performed with an ongoing cohort of HIV/AIDS subjects in Mexico City (September 2013-February 2015)...
January 30, 2018: Journal of Oral Pathology & Medicine
Maite Pena-Cristóbal, Márcio Diniz-Freitas, Luis Monteiro, Pedro Diz Dios, Saman Warnakulasuriya
BACKGROUND: Citations analysis is one of the most widely used bibliometric tools to evaluate the academic importance of a study in a specific area of knowledge. The objective of the present study was to identify the 100 most cited articles on oral cancer and to analyse their principal characteristics. METHODS: We performed a literature search in the Web of Science database using the Science Citation Index Expanded tool to determine the number of citations of all articles on oral cancer identified up to 10th August 2017...
January 30, 2018: Journal of Oral Pathology & Medicine
Sadeq Ali Al-Maweri, Sajna Ashraf, Butchibabu Kalakonda, Esam Halboub, Waleed Petro, Nader Ahmed AlAizari
BACKGROUND: The aim of the present study was to systematically review the efficacy of photodynamic therapy (PDT) in the management of symptomatic oral lichen planus (OLP). MATERIALS AND METHODS: PubMed/MEDLINE, Scopus, and ISI Web of knowledge were searched until July 2017, using the following keywords: oral lichen planus, erosive lichen planus, lichen planus, and photodynamic therapy. RESULTS: Five clinical studies were included. The risk of bias was considered high in four studies and moderate in one study...
January 19, 2018: Journal of Oral Pathology & Medicine
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