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Journal of Oral Pathology & Medicine

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https://www.readbyqxmd.com/read/27882603/establishment-and-characterization-of-a-cell-population-derived-from-a-dentigerous-cyst
#1
Marcos A Muñiz-Lino, Mariana Rodríguez-Vázquez, Bibiana Chávez-Munguía, Josué Z Ortiz-García, Lorena González-López, Fidel C Hernández-Hernández, Carlos Licéaga-Escalera, Alejandro García-Muñoz, Mario A Rodríguez
BACKGROUND: Dentigerous cyst occurs in approximately 20% of jaw cysts, being the second major common odontogenic cyst, after radicular cyst. This oral lesion has the ability to destroy maxillary bones and could be the origin of several odontogenic tumors. However, molecules implicated in its pathogenesis as well as those involved in its neoplastic transformation remain unknown. Here, we established a cell population derived from a dentigerous cyst as an in vitro model for the study of this oral lesion...
November 24, 2016: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/27873361/effect-of-hiv-infection-in-the-microuclei-frequency-on-the-oral-mucosa
#2
Celina Faig Lima, Monica Ghislaine Oliveira Alves, Juvencio Jose Duailibe Furtado, Marcelo Marcucci, Ivan Balducci, Janete Dias Almeida
BACKGROUND: the genotoxic impact of HIV infection on the oral cavity malignancies is unknown. The aim of this study was to evaluate the effect of HIV infection in micronuclei (MN) frequency on the oral mucosa of HIV+ patients and establish a relationship with early cytogenetic changes in oral carcinogenesis. METHODS: 30 HIV + individuals who are under highly active antiretroviral therapy (HAART) and 30 non HIV patients were evaluated. Two smears were taken from the lateral border of the tongue and mouth floor and stained by Feulgen...
November 22, 2016: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/27864904/an-update-on-the-current-management-of-head-and-neck-mucosal-melanoma
#3
REVIEW
Ben Green, Ahmed Elhamshary, Ricardo Gomez, Siavash Rahimi, Peter A Brennan
Primary mucosal melanomas of the head and neck are rare and aggressive tumours that arise in the nasal cavity, paranasal sinuses and more rarely, in the oral cavity. The current treatment options include radical surgical resection with adjuvant external beam radiotherapy being offered in high risk patients. Although the latter can improve regional control, it does not reduce overall survival. Elective neck dissection is recommended for nodular oral mucosal melanoma but its role in the clinically node negative neck is controversial...
November 19, 2016: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/27859616/immunohistochemical-expression-of-podoplanin-d2-40-lymphangiogenesis-and-neoangiogenesis-in-tooth-germ-ameloblastomas-and-ameloblastic-carcinomas
#4
Celeste Sánchez-Romero, Ronell Bologna-Molina, Adalberto Mosqueda-Taylor, Oslei Paes de Almeida
BACKGROUND: Ameloblastoma is a benign but locally aggressive odontogenic tumor, while ameloblastic carcinoma is its malignant counterpart. Angiogenesis and lymphangiogenesis in malignancies have been correlated with higher aggressiveness and poor prognosis, as well as greater expression of podoplanin by tumoral cells. METHODS: Immunohistochemical expression of podoplanin, CD34, and CD105 (endoglin) was evaluated in 53 ameloblastomas and three ameloblastic carcinomas; additionally, immunohistochemistry for podoplanin was also performed in 10 tooth germs...
November 10, 2016: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/27862315/evaluation-of-salivary-nitric-oxide-levels-and-c-reactive-protein-in-patients-with-oral-lichen-planus-and-burning-mouth-syndrome
#5
Tvarijonaviciute Asta, Aznar Cayuela Cristina, Peres Rubio Camila, Ceron José Joaquin, Pia López-Jornet
OBJECTIVES: The aim of this study was to evaluate oxidative stress factors and C-reactive protein in the saliva of patients with oral lichen planus (OLP) and burning mouth syndrome (BMS). METHODS: This consecutive, cross-sectional study included 20 patients with OLP, 19 with burning mouth syndrome (BMS), and 31 control subjects. The oral cavity of each patient was examined and patients responded to a quality of life questionnaire (OHIP-14) and the Xerostomia Inventory...
November 8, 2016: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/27862305/a-loss-of-profilin-1-in-late-stage-oral-squamous-cell-carcinoma
#6
Guy R Adami, Thomas N O'Callaghan, Antonia Kolokythas, Robert J Cabay, Yalu Zhou, Joel L Schwartz
BACKGROUND: The genes for PFN1 and TMSB4 are both highly expressed in oral tissue and both encode actin monomer binding proteins thought to play a role in cell motility and possibly other crucial parts of tumor progression. METHODS: Oral brush cytology of epithelium from Oral Squamous Cell Carcinoma (OSCC) was used to measure PFN1 and TMSB4 mRNA in OSCC while immunohistochemical analysis of tissue was used to check protein levels. RESULTS: High but variable expression of mRNAs encoding these two proteins was observed suggesting they may contribute to tumor characteristics in a subset of OSCCs...
November 8, 2016: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/27889943/a-clinicopathological-study-of-the-oral-lesions-of-cowden-disease
#7
Mariana Hammerschmidt, Silvia Vanessa Lourenço, Marcello Menta Simonsen Nico
BACKGROUND: Cowden disease is a multisystemic cancer predisposition disorder, inherited in an autosomal dominant pattern. Cutaneous and visceral lesions are either malignant tumours or are believed to represent hamartomatous growths. Mucocutaneous lesions are present on almost 100% of affected individuals. Nonetheless, some authors consider that the mucocutaneous manifestations of Cowden disease are, in reality, viral warts at distinct steps of evolution. There are only a few studies regarding the oral manifestations of Cowden disease...
November 7, 2016: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/27889928/elucidating-the-role-of-cyclooxygenase-2-in-the-pathogenesis-of-oral-lichen-planus-an-immunohistochemical-study-with-supportive-histochemical-analysis
#8
Pratyush Singh, Jasleen Grover, Aditi Amit Byatnal, Vasudeva Guddattu, Raghu Radhakrishnan, Monica Charlotte Solomon
OBJECTIVE: Oral lichen planus (OLP) is a chronic, inflammatory disorder that affects the oral mucous membrane. During an inflammatory response, several chemokines and cytokines are released by the cells of the immune system. Activation of MMPs, along with mast cell-derived chymase and tryptase, degrades the basement membrane structural proteins, resulting in basement membrane breaks. AIM: To investigate the association between the COX-2 expressions, presence of intact or degranulating mast cells within the connective tissue and the extent of basement membrane discontinuity in OLP cases...
November 7, 2016: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/27883362/a-risk-factor-based-model-for-upper-aerodigestive-tract-cancers-in-india-predicting-and-validating-the-receiver-operating-characteristic-curve
#9
Bhawna Gupta, Narinder Kumar, Newell W Johnson
BACKGROUND: A study was conducted to develop and validate a screening model using risk scores to identify individuals at high risk for developing upper aerodigestive tract (UADT) cancers in an Indian population. METHODS: A hospital-based case-control study (n = 480) was conducted in Pune, India. We assessed risk factors for UADT cancers by administering a questionnaire through face-to-face interviews. We developed a risk factor model based on the statistically significant risk factors in multiple logistic regression...
November 7, 2016: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/27873358/regarding-whatsapp-is-an-effective-tool-for-obtaining-second-opinion-in-oral-pathology-practice
#10
LETTER
Bacem A Khalele
No abstract text is available yet for this article.
November 7, 2016: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/27805722/treatment-of-chemically-induced-oral-ulcer-using-adipose-derived-mesenchymal-stem-cell-sheet
#11
Doh Young Lee, Hee-Bok Kim, In Kyoung Shim, Nobuo Kanai, Teruo Okano, Seong Keun Kwon
BACKGROUND: This study investigated the effects of mesenchymal stem cell (MSC) sheet transplantation on healing of chemically induced oral ulceration in a rabbit animal model. METHODS: Oral mucosal ulcers were induced by topical application of filter paper soaked with 70% acetic acid to the anterior gingiva and buccal mucosa of 12 New Zealand white rabbits. The animals were randomly assigned to two groups: with (treatment group, n = 6) or without (control group, n = 6) cell sheets applied to ulcers...
November 2, 2016: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/27800633/evaluation-of-salivary-catalase-vitamin-c-and-alpha-amylase-in-smokers-and-non-smokers-a-retrospective-cohort-study
#12
Fatemeh Ahmadi-Motamayel, Parisa Falsafi, Mohammad Taghi Goodarzi, Jalal Poorolajal
BACKGROUND: Saliva and its defence systems such as antioxidants and minerals are very important in the pathogenesis of different diseases. Cigarette smoking has many destructive effects. Oxidative stresses play an important role in the side effects of smoking. This study assessed the effect of cigarette smoking on salivary levels of catalase, vitamin C, and α-amylase. METHODS: This retrospective cohort study was carried out in Hamadan, Iran, on 510 subjects; 259 subjects were smokers (the exposed group) and 251 were non-smokers (the unexposed group)...
November 1, 2016: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/27778394/use-of-new-targeted-cancer-therapies-in-children-effects-on-dental-development-and-risk-of-jaw-osteonecrosis-a-review
#13
Magali Hernandez, Bérengère Phulpin, Ludovic Mansuy, Dominique Droz
New targeted cancer therapies such as bisphosphonates, denosumab and bevacizumab are routinely used in adult for the past decades. Their introduction into pediatric medicine is more recent that means there is a paucity of data on long-term effects on dental development and on the risk of osteonecrosis of jaw. This paper aims to outline adverse effects of new targeted cancer therapies on oral cavity including dental abnormalities observed in pediatric population treated with these molecules and the risk of osteonecrosis of the jaw (ONJ)...
October 25, 2016: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/27770472/whatsapp-is-an-effective-tool-for-obtaining-second-opinion-in-oral-pathology-practice
#14
Sachin C Sarode, Gargi S Sarode, Rahul Anand, Shankargouda Patil, Hemant Unadkat
BACKGROUND: The aim of this study was to find out the efficacy of WhatsApp application for obtaining second opinion on histopathological diagnosis in oral pathology practice. METHODS: A total of 247 cases comprising of 34 different oral pathologies were photomicrographed using smartphone cameras through compound microscopes and sent for second opinion diagnosis (SOD) to 20 different oral pathologists using WhatsApp. RESULTS: Of 4795 (97.06%) total second opinion received, correct SOD were received for 4710 (98...
October 22, 2016: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/27766688/effects-of-bisphosphonates-on-mandibular-condyle-of-ovariectomized-osteoporotic-rats-using-micro-ct-and-histomorphometric-analysis
#15
Liting Jiang, Xing Shen, Li Wei, Qi Zhou, Yiming Gao
OBJECTIVE: To evaluate microarchitectural changes in condylar cartilage and associated subchondral bone after bisphosphonates treatment using an ovariectomized (OVX) osteoporosis rat model. METHODS: Thirty six-month-old female Sprague-Dawley rats were randomly divided into sham, OVX, and risedronate (RIS)-treated groups. Both OVX and RIS groups received bilateral ovariectomy. OVX group was treated subcutaneously with saline, whereas RIS group received risedronate treatment (2...
October 21, 2016: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/27759906/quantitative-and-functional-analysis-of-cd69-t-regulatory-lymphocytes-in-patients-with-periodontal-disease
#16
Marlen Vitales-Noyola, Rita Martínez-Martínez, Juan P Loyola-Rodríguez, Lourdes Baranda, Perla Niño-Moreno, Roberto González-Amaro
BACKGROUND: Periodontal disease is chronic inflammatory process that affects the attachment structures of the teeth and constitutes a significant cause of tooth loss in adults. Although different bacteria play an important role in the triggering of this condition, the progression and severity of the disease are strongly affected by the host immune response, which is under the control of different immune regulatory mechanisms, including T regulatory (Treg) cells. The aim of this study was to assess the frequency and function of CD69(+) Treg lymphocytes in patients with chronic periodontal disease...
October 19, 2016: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/27743497/limited-mouth-opening-in-oral-submucous-fibrosis-reasons-ramifications-and-remedies
#17
Mohit Sharma, Raghu Radhakrishnan
Limited mouth opening (LMO) in Oral Submucous Fibrosis (OSF) has been attributed to both the submucosal and muscle fibrosis (MF). While, reflectory trismus was proposed before as an auxiliary mechanism by another group; the stretch mediated muscle damage (MSD), histopathological changes in blood vessels (like endothelial dysfunction, endothelial hypertrophy and endarteritis obliterans) and upregulated anaerobic isoforms of lactate dehydrogenase (LDH), have been proposed by us as complementary events leading to MF...
October 15, 2016: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/27732748/the-relationship-between-proteoglycan-inhibition-via-xylosetransferase-ii-silencing-and-the-implantation-of-salivary-pleomorphic-adenoma
#18
Huijuan Liu, Jie Wang, Guiyun Ren, Yanning Zhang, Fusheng Dong
OBJECTIVE: To study the relationship between proteoglycan inhibition and the implantation of salivary pleomorphic adenoma (SPA). METHODS: SPA fresh tissue was primitively cultured and identified. The Ad-shRNA-XT-II adenovirus vector was constructed and transfected into SPA cells to silence the XT-II gene. The expression of the XT-II gene and protein was detected using real-time PCR and western blotting, respectively. The proteoglycan content of the cells was determined 48 hours after transfectction...
October 12, 2016: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/27732739/image-analysis-of-fatty-infiltration-in-labial-salivary-gland-biopsies-extent-and-its-correlation-to-age-obesity-and-diabetes
#19
Krisztián Katona, Eszter Elekes, Nelli Farkas, Mária Kneif, Gábor Sütő, Tamás Tornóczky
BACKGROUND: Fatty infiltration of minor salivary gland parenchyma is relatively frequent, but not extensively examined histopathological phenomenon in biopsy samples. Its extent and relation to several suspected background diseases are not well understood. METHODS: In the present study we examined the presence and extent of fatty infiltration on digitally scanned versions of the periodic acid-Schiff -stained minor salivary gland slides of 275 patients. As a result of the image analysis fatty infiltration was expressed in percent of the whole selected area...
October 12, 2016: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/27732737/tyrosine-kinase-inhibitor-tki-258-inhibts-cell-motility-in-oral-squamous-cell-carcinoma-in-vitro
#20
Anna Cecília Dias Maciel Carneiro, Isadora Caixeta da Silveira, Arthur Silva Rezende, Bruna Raphaela Oliveira Silva, Virgínia Oliveira Crema
BACKGROUND: Oral squamous cell carcinoma is extremely invasive, this behavior is regulated by binding of extracellular molecules to the cell membrane receptors. The TKI-258 inhibits phosphorylation of FGFRs VEGFRs and PDGFRs. Our aim was to analyze the effect of TKI-258 treatment in cell movement by using SCC-4 cell line from human oral squamous cell carcinoma. METHODS: F-actin was stained with rhodamine phalloidin and confocal analysis was performed. The migration and invasion (membrane covered with Matrigel(TM) ) three-dimensional assays were performed, control and cells treated with TKI-258 that migrated through the membrane were counted after 24 h...
October 12, 2016: Journal of Oral Pathology & Medicine
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