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Journal of Oral Pathology & Medicine

Shankargouda Patil, Krishna Patel, Jayshree Advani, Tejaswini Subbannayya, Pavithra Rajagopalan, Niraj Babu, Hitendra Solanki, Shilpa Bhandi, David Sidransky, Aditi Chatterjee, Harsha Gowda, Marco Ferrari
BACKGROUND: Tobacco is smoked in different form including cigarettes and water pipes. One popular form of water pipe smoking especially in Middle Eastern countries is shisha smoking. Shisha has been associated with various diseases including oral cancer. However, genomic alterations and gene expression changes associated with chronic shisha exposure have not been previously investigated. OBJECTIVES: Whole exome sequencing and gene expression profiling of immortalized human oral keratinocytes (OKF6/TERT1) cells chronically treated with 0...
January 19, 2019: Journal of Oral Pathology & Medicine
Bruno Ramos Chrcanovic, Mauro Henrique Nogueira Guimarães Abreu, Peter A Brennan, Ricardo Santiago Gomez
There are many pathologic conditions which occur in the maxillofacial region. Some are rare with only isolated case reports in the literature. In order to get a general picture of such lesions, it is common practice to gather information described in the literature, analyze the data, and write systematic reviews. This article is protected by copyright. All rights reserved.
January 16, 2019: Journal of Oral Pathology & Medicine
Junjun Chen, Guanhuan Du, Yuzhou Chang, Yufeng Wang, Linjun Shi, Jun Mi, Tang Guoyao
BACKGROUND: MicroRNA-27b (miR-27b) was recently found to be significantly downregulated in oral lichen planus (OLP). However, evidence of the function of miR-27b in OLP remains limited. METHODS: Initially, miR-27b expression in OLP was verified using the quantitative real-time polymerase chain reaction (qRT-PCR). Functional, gain-/loss-of-function studies were then conducted using miR-27b mimics/inhibitor to investigate cell growth in human oral keratinocytes (HOKs)...
January 14, 2019: Journal of Oral Pathology & Medicine
Federica Baldan, Lorenzo Allegri, Milos Lazarevic, Catia Mio, Maja Milosevic, Giuseppe Damante, Jelena Milasin
BACKGROUND: Despite improvements in oral squamous cell carcinoma (OSCC) management, survival rates remain relatively low and novel anti-neoplastic agents are needed. Bromodomain and extra-terminal (BET) inhibitors proved to be promising agents for cancer treatment. We investigated the effects of three BET inhibitors (JQ1, IBET-151, IBET-762) on SCC-25 cell line and primary oral cancer cell culture. METHODS: Cell viability was evaluated by MTT. Protein levels of MCM5 and cleaved-PARP were estimated by Western blot...
January 8, 2019: Journal of Oral Pathology & Medicine
Yingci Liu, Liron Pantanowitz
Whole slide imaging (WSI) has impacted the practice of pathology in the arenas of education, clinical practice, and research. With digital slides, pathologists can circumvent the limitations of traditional glass. Presently, digital pathology is primarily utilized for second opinion consults, clinical conferences, and education at select academic medical centers, with its mainstream adoption on the rise. However, challenges of adoption for oral pathologists are unique given the highly specialized nature of their work...
January 8, 2019: Journal of Oral Pathology & Medicine
Shankargouda Patil, Kamran Habib Awan, Gururaj Arakeri, Abdulsalam Aljabab, Marco Ferrari, Carolina C Gomes, Ricardo S Gomez, Peter A Brennan
INTRODUCTION: There has been a recent rise in popularity of waterpipe smoking (WPS) amongst younger people. While it is a tobacco-related product, research on the possible deleterious effects on health and its relationship with cancer is sparse. In this paper, we evaluated the existing literature and association of WPS with head and neck cancer. MATERIALS AND METHODS: PubMed, EMBASE, Scopus, Web of Science, and grey literature from January 1990 up to and including March 2017 were searched...
January 3, 2019: Journal of Oral Pathology & Medicine
Gururaj Arakeri, Abdulsalam Aljabab, M Nagaraj, Santosh Hunasgi, Shekar Patil, Beverly Hale, Matthias A W Merkx, Carolina C Gomes, Ricardo S Gomez, Peter A Brennan
BACKGROUND: Despite much research, there is a lack of a definite protocol or method for documenting oral submucous fibrosis (OSMF) site presentation. In this study we propose a new potential oral mapping (OM) method and evaluated its use in recording OSMF affected mucosal sites. METHODS: 50 OSMF patients were evaluated by 15 primary care dental practitioners using both, a conventional subjective recording method and a new OM method, to document the degree of involvement of affected oral mucosa with a crossover study design...
January 3, 2019: Journal of Oral Pathology & Medicine
Kamran Habib Awan, Shankargouda Patil, Abdul Wahab H Alamir, M Nagaraj, Gururaj Arakeri, Marco Carrozzo, Peter A Brennan
INTRODUCTION: Critical evidence on the therapeutic efficacy of botulinum toxins (BTX) is still lacking for most pain conditions. The aim of this review was to evaluate the therapeutic efficacy of BTX in the management of temporomandibular myofascial pain. MATERIALS AND METHODS: Electronic databases PubMed, EMBASE, Scopus, Web of Science, and grey literature were searched for randomized clinical trials until February 2018 to answer a focused question "What is the effectiveness of botulinum toxin in the management of temporomandibular myofascial pain?" Two independent reviewers performed the study selection according to eligibility criteria...
January 3, 2019: Journal of Oral Pathology & Medicine
Katya Pulido Díaz, Rogério Gondak, Leandro Martins Liporoni, Oslei Paes de Almeida, Jorge Esquiche León, Fernanda Viviane Mariano, Albina Altemani, Pablo Agustin Vargas
BACKGROUND: Fatty Acid Synthase (FASN) is the key molecule for catalyzing fatty acid synthesis and have been associated with several malignant tumors. METHODS: We analyzed the expression of FASN and Ki-67, by immunohistochemistry on 29 carcinomas ex-pleomorphic adenoma (CXPAs) and 25 pleomorphic adenomas (PAs). RESULTS: Ki-67 proliferation index and FASN expression were significantly higher in patients with CXPA than patients with PA (P < 0...
December 29, 2018: Journal of Oral Pathology & Medicine
Haofei Xiong, Wei Li, Jiajie Li, Wei Fang, Jin Ke, Bo Li, Yong Cheng, Lili Wei
BACKGROUND: Leptin, through binding to its special receptor (Ob-Rb), has potent effects on immunity and inflammation. This study measured the levels of leptin in the synovial fluid of patients with temporomandibular joint osteoarthritis (TMJ-OA) and healthy controls, determined the expression of Ob-Rb and explored the effects and signalling pathways involved in leptin-induced proinflammatory cytokine interleukin (IL)-6 production in TMJ synovial fibroblasts (TMJ-SFs). METHODS: Synovial fluid samples were obtained from 16 patients with TMJ-OA and seven healthy controls...
December 29, 2018: Journal of Oral Pathology & Medicine
C Gilvetti, J Collyer, A Gulati, A W Barrett
BACKGROUND: The aim of this study was to determine which biopsy method produces the best diagnostic yield in patients presenting with autoimmune blistering diseases (AIBDs) of the oral mucosa. METHODS: This was a retrospective audit of patients who were biopsied at least once for a suspected AIBD of the oral mucosa. The type (incisional or punch) and site of biopsies was recorded in conjunction with case notes, electronic records and histopathological reports in order to calculate sensitivity, specificity and the method of biopsy which produced the superior diagnostic yield...
December 23, 2018: Journal of Oral Pathology & Medicine
Woori Park, Hyunsik Bae, Min-Hae Park, Na Young Hwang, Insuk Sohn, Junhun Cho, Han-Sin Jeong
BACKGROUND: The Milan System for Reporting Salivary Gland Cytopathology (Milan System) has previously shown its diagnostic utility by categorizing the seven cytology findings in salivary gland lesions. However, there has been lack of study about the risk of high-grade malignancy in the cytology diagnosis based on the Milan System. Thus, we tried to identify the diagnostic ability of the Milan System for high-grade malignancy and to suggest an improved diagnostic approach for preoperative estimation of high-grade malignancy using the Milan System...
December 21, 2018: Journal of Oral Pathology & Medicine
Daniele Borsetto, James A Higginson, Adil Aslamb, Laith Al-Qamachib, Jag Dhandab, Gino Marioni, Sebastiano Franchella, Annachiara Frigo, Prav Praveen, Tim Martin, Sat Parmar, Paul Nankivell
BACKGROUND: Recurrence of oral squamous cell carcinoma (rOSCC) after primary treatment is associated with poor survival outcomes. Salvage treatment with further surgery, radiotherapy and chemotherapy has high morbidity, making patient selection crucial. However, in the recurrence setting, reliable stratification data are scarce. Decision-making in this context is consequently complex. We investigated factors influencing overall survival after rOSCC. METHODS: Retrospective cohort study of patients with rOSCC (n = 83) at the Queen Elizabeth Hospital Birmingham, UK between 2006 and 2016...
December 21, 2018: Journal of Oral Pathology & Medicine
Adarsh Kudva, Abhay T Kamath, Vasantha Dhara, Vineetha Ravindranath
BACKGROUND: Chronic recurrent forms of osteomyelitis of the mandible with their morbid clinical course have long been considered a challenge to maxillofacial surgeons in terms of both diagnosis and treatment. Various classifications and treatments have been established through the ages to define and manage the inflammatory symptoms occurring in adults and children. This paper discusses two such entities occurring in an adult and a child, highlighting the diagnostic and treatment challenges of recurrent osteomyelitis...
December 18, 2018: Journal of Oral Pathology & Medicine
Victor Coutinho Bastos, Núbia Braga Pereira, Marina Gonçalves Diniz, Luciana Oliveira Andrade, Wagner Henriques Castro, Gregory Thomas Kitten, Ricardo Santiago Gomez, Carolina Cavalieri Gomes
BACKGROUND: Benign neoplasms exhibit most of the cellular phenomena considered hallmarks of cancer, except the capacity to metastasize. Thus, the elucidation of the mechanisms associated with the progression of benign neoplasms may complement and clarify the mechanisms involved in carcinogenesis. Benign odontogenic tumours often result in facial deformities and morbidities, and have complex pathogenesis, mainly due to the diversity of interactions between the odontogenic epithelium and the ectomesenchyme...
December 16, 2018: Journal of Oral Pathology & Medicine
Xiu-Mei Zhuang, Bin Zhou
BACKGROUND: The chemokine receptor 4 (CXCR4) plays an important role in tumor progression. Overexpressed CXCR4 is associated with a poor prognosis of patient with head and neck squamous cell carcinomas. However, the correlation between CXCR4 and chemotherapy resistance in tongue squamous cell carcinoma (TSCC) remains obscure. METHODS: Stable cisplatin-resistant CAL27 CDDP and SCC25 CDDP cells were established and identified by CCK8 assay, and the CXCR4 expression was detected using qRT-PCR and western blot...
December 16, 2018: Journal of Oral Pathology & Medicine
Ahmed S Sultan, Maryam Jessri, Camile S Farah
There is a paucity of evidence surrounding the potential detrimental effects of electronic nicotine delivery systems (ENDS) for both systemic and oral health. The effects of conventional cigarettes on the development of oral cancer are well known, however the role of ENDS in oral carcinogenesis is yet to be elucidated. Furthermore, the exponential rise of the use of ENDS by the general public means that dental healthcare providers are more likely to encounter questions on their safety in the oral cavity, and on their effectiveness as a smoking cessation aid...
December 3, 2018: Journal of Oral Pathology & Medicine
Jie Li, Xiang-Bo Kong, Xue-Ying Chen, Wan-Zhen Zhong, Jie-Yu Chen, Yang Liu, Ping Yin, Si-Lian Fang
OBJECTIVE: We have previously demonstrated the effect of alpha-2-macroglobulin (α2M) in the remediation of radiation-induced cellular damage. Here, we investigated the protective effects of α2M in a preclinical rat model of jaw osteoradionecrosis (ORN). METHODS: Eighteen rats were divided randomly into three groups: the control group, the radiation therapy (RT) alone group, and the radiated mandibles pretreated with α2M (α2M + RT) group. One month after radiation, all left molar teeth were extracted...
December 1, 2018: Journal of Oral Pathology & Medicine
Vito Carlo Alberto Caponio, Giuseppe Troiano, Gerardo Botti, Maria Carmela Pedicillo, Lucio Lo Russo, Filiberto Mastrangelo, Domenico Ciavarella, Nunzia Simona Losito, Gabriella Aquino, Riccardo Nocini, Rossella Santoro, Angela Santoro, Lorenzo Lo Muzio, Giuseppe Pannone
BACKGROUND: ADAR1 is an enzymatic protein, which catalyzes a RNA-editing reaction by converting Adenosine to Inosine and its expression has been found to be dysregulated in many cancer types. The aim of this study was to analyze the expression of ADAR1 in oral squamous cells carcinoma. METHODS: In order to analyze the ADAR1 mRNA expression, data from The Cancer Genome Atlas (TCGA) database were downloaded and analyzed. In addition, immunohistochemistry analysis was performed on an institutional database including 46 samples of oral squamous cell carcinoma in a tissue microarray (TMA)...
November 29, 2018: Journal of Oral Pathology & Medicine
Zhu You, Liu Shao-Peng, Du Jing, W U Yi-Hua, Shi-Zhou Zhang
Numerous signal transduction pathways are closely associated with the occurrence, development, and prognosis of ameloblastoma(AM). Mitogen-activated protein kinase (MAPK) is a serine/threonine-specific protein kinase that transduces intracellular signals in critical cellular phenomena. A number of recent analyses have reported that the MAPK signaling pathway contributes significantly to AM. High-throughput DNA sequencing methods, such as next-generation sequencing using Illumina have yielded advancements in studies on MAPK signaling pathways and their association with AM; in particular, BRAF V600E is mediated by the activation of the Ras/Raf/MAPK pathway...
November 29, 2018: Journal of Oral Pathology & Medicine
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