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Journal of Oral Pathology & Medicine

Sureewan Bumrungthai, Tipaya Ekalaksananan, Darin Duangchai, Pornsiri Lanpol, Papichaya Panya, Fernladda Kattiwong, Sulav Acharya, Chamsai Pientong
BACKGROUND: The incidence of oral cancers associated with human papillomavirus (HPV) has been increasing in recent years. Therefore, it is necessary to elucidate HPV prevalence in oral cells and exposure to risk factors in various age groups. METHODS: Oral rinse samples from healthy individuals in northern Thailand were investigated for HPV prevalence and genotyped using the polymerase chain reaction (GP5+/6+ primers) and DNA sequencing of the PCR products. RESULTS: Samples were collected from 594 participants between 4 and 60 years of age...
November 11, 2018: Journal of Oral Pathology & Medicine
Carla Isabelly Rodrigues-Fernandes, Lucas Lacerda de Souza, Sara Ferreira Dos Santos-Costa, Hélder Antônio Rebelo Pontes, Oslei Paes de Almeida, Pablo Agustin Vargas, Javier Rendón Henao, Siavash Rahimi, Peter A Brennan, Felipe Paiva Fonseca
BACKGROUND: Diffuse large B-cell lymphoma, NOS (DLBCL NOS) is the commonest extranodal non-Hodgkin lymphoma diagnosed in the oral and maxillofacial region. However, few studies are currently available and its prognostic determinants still remain undefined. PURPOSE: To analyse the available data on oral DLBCL NOS and to describe its clinicopathological features, identifying potential prognostic factors. METHODS: An electronic systematic search was performed using multiple databases with a specific search strategy in April 2018...
November 10, 2018: Journal of Oral Pathology & Medicine
Fumio Ide, Naoyuki Matsumoto, Yuji Miyazaki, Kentaro Kikuchi, Kaoru Kusama
We were impressed with the meticulous attention to detail regarding the recurrence of adenomatoid odontogenic tumor (AOT) in the recent article by Chrcanovic and Gomez.1 It was a pleasure to learn that they had taken an interest in our report on AOT recurrence (see Supporting Information).1 This letter focuses on the unanswered questions relating to two cases of recurrent AOT published in Japanese to which Chrcanovic and Gomez1 referred. This article is protected by copyright. All rights reserved.
November 7, 2018: Journal of Oral Pathology & Medicine
Thaís Dos Santos Fontes Pereira, Carolina Cavalieri Gomes, Peter A Brennan, Felipe Paiva Fonseca, Ricardo Santiago Gomez
Fibrous dysplasia is a non-neoplastic developmental process that affects the craniofacial bones, characterized by painless enlargement as a result of bone substitution by abnormal fibrous tissue. Postzygotic somatic activating mutations in the GNAS1 gene cause fibrous dysplasia and have been extensively investigated, as well as being helpful in the differential diagnosis of the disease. Fibrous dysplasia may involve one (monostotic) or multiple bones (polyostotic), sporadically or in association with McCune-Albright syndrome, Jeffe-Lichenstein syndrome or Mazabreud syndrome...
October 30, 2018: Journal of Oral Pathology & Medicine
Fereshteh Baghaei, Alireza Abdollahi, Hadiseh Mohammadpour, Mahsa Jahanbin, Fatemeh Naseri Taheri, Pouyan Aminishakib, Amirnader Emami Razavi, Mohamadjavad Kharazifard
BACKGROUNDS: Oral Squamous Cell Carcinoma (OSCC) is the most common malignancy of the oral cavity. Phosphatase and TENsin homolog (PTEN) is a well-known tumor suppressive gene regulated by several biomarkers including a small single stranded molecule, microRNA26b (miR-26b). Here, we studied the expression of PTEN and miR-26b in OSCC specimens in comparison with adjacent normal mucosa. METHODS: The expressions of PTEN and miR-26b genes were evaluated at mRNA level in OSCC and adjacent normal fresh frozen tissues in forty nine patients using Quantitative Real-Time PCR and analyzed their associations with clinicopathological factors...
October 29, 2018: Journal of Oral Pathology & Medicine
Jiajie Li, Bo Li, Yong Cheng, Qingong Meng, Lili Wei, Wei Li, Jiali Zhang, Shengfu Huang
BACKGROUND: Sialadenitis is a nonneoplastic disease that causes salivary dysfunction. Autophagy may be involved in helping protect salivary function when the salivary gland is impaired; this process is primarily activated by sensors of innate immunity, such as Toll-like receptors and nucleotide-binding oligomerization domain (NOD)-like receptors. The role of these pattern recognition receptors (PRRs) in the regulation of salivary gland tissue defense and homeostasis has been underappreciated...
October 26, 2018: Journal of Oral Pathology & Medicine
Xiaolian Gu, Philip J Coates, Linda Boldrup, Lixiao Wang, Adam Krejci, Ted Hupp, Robin Fahraeus, Lena Norberg-Spaak, Nicola Sgaramella, Torben Wilms, Karin Nylander
BACKGROUND: The incidence of squamous cell carcinoma of the oral tongue (SCCOT) is increasing in people under age 40. There is an urgent need to identify prognostic markers that help identify young SCCOT patients with poor prognosis in order to select these for individualized treatment. MATERIALS AND METHODS: To identify genetic markers that can serve as prognostic markers for young SCCOT patients, we first investigated four young (≤40 years) and five elderly patients (≥50 years) using global RNA sequencing and whole-exome sequencing...
October 25, 2018: Journal of Oral Pathology & Medicine
Fariah I Gaba, Chirag C Sheth, Veronica Veses
BACKGROUND: More than 90% of malignant tumors of the head and neck are oral squamous cell carcinomas. Early detection of oral squamous cell carcinoma using salivary biomarkers could prevent malignant transformations and enhance patient survival. METHODS: A systematic search in MEDLINE and the Central Register of Controlled Trials and meta-analysis were undertaken to identify the screening potential of six salivary biomarkers for early oral squamous cell carcinoma detection: interleukins IL-8 and IL1-β, DUSP-1 and S100P messenger RNAs, and miR125a and miR200a microRNAs...
October 19, 2018: Journal of Oral Pathology & Medicine
Jun Shen, Cao Yin, Xiao Jiang, Xuan Wang, Shujuan Yang, Guangbao Song
BACKGROUNDS: To investigate alterations in histone modification and histone deacetylases (HDACs) in patients with oral lichen planus (OLP), and to evaluate correlations with inflammatory cytokine production. METHODS: Global histone H3/H4 acetylation and HDAC activity in CD4+ T cells from 23 patients with OLP and 10 healthy control subjects were examined using spectrophotometry. The mRNA levels of 8 members of 4 classes of HDAC genes were measured by real-time quantitative polymerase chain reaction...
October 17, 2018: Journal of Oral Pathology & Medicine
Sadeq Ali Al-Maweri, Sajna Ashraf, Amara Swapna Lingam, Ahmed Alqutaibi, Saleem Abdulrab, Nader Alaizari, Esam Halboub
The management of oral submucous fibrosis (OSF) is quite challenging, and as yet, no effective therapy is available for its management. The present systematic review and meta-analysis sought to assess the effectiveness of aloe vera in alleviating pain and clinical signs of OSF. A comprehensive search in Pubmed/Medline, Scopus, and Web of Science databases was conducted to identify the relevant randomized clinical trials. RevMan 5.3 software was used for data analysis. Six randomized controlled trials fulfilled the inclusion criteria...
October 17, 2018: Journal of Oral Pathology & Medicine
Lizhong Liang, Junquan Weng, Yingying You, Qifen He, Yunping Fan, Guiqing Liao
BACKGROUND: Noxa, which is subset of the Bcl-2 family of proteins, was previously reported to have considerable therapeutic potential in diverse cancers. However, its expression and role in salivary gland adenoid cystic carcinoma (ACC) have not been well studied. This study aimed to elucidate the expression and role of Noxa in salivary gland ACC. MATERIALS AND METHODS: The expression levels of NOXA and its association with overall survival in salivary gland ACC were analyzed by quantitative real-time PCR...
October 5, 2018: Journal of Oral Pathology & Medicine
Yingjie Li, Yaping Feng, Pinyin Cao, Jin Ke, Wei Fang, Hengxing Cai, Mohong Deng, Xing Long
BACKGROUND: Synovial chondromatosis (SC) of temporomandibular joint (TMJ) occupies 3% SC cases. In other joints like hip and knee which were composed hyaline cartilage (HC), loose bodies (LBs) were reported to be a HC feature. However, condyle surface and disc in TMJ are fibrous cartilage (FC). Therefore, we proposed a different pathogenesis of TMJSC. METHODS: LBs and synovium were collected from seven TMJSC patients, and histological and immunohistological examinations were performed...
October 5, 2018: Journal of Oral Pathology & Medicine
Rogério Gonçalves da Rocha, Eliane Macedo Sobrinho Santos, Eloá Mangabeira Santos, Emisael Stênio Batista Gomes, Guilherme Veloso Ramos, Karina Marini Aguiar, Bruno Rodrigues Gonçalves, Sérgio Henrique Sousa Santos, Alfredo Maurício Batista de Paula, André Luiz Sena Guimarães, Lucyana Conceição Farias
PURPOSE: Leptin, an important hormone controlling energy homeostasis, has been linked to the pathogenesis of oral squamous cell carcinoma (OSCC). Evidence indicates that head and neck cancer patients undergoing radiotherapy shows decreased leptin levels after radiotherapy treatment. Thus, we investigated, through phenotypic and molecular analyses, whether leptin can compromise the therapeutic effect of ionizing radiation and neoplastic behavior of OSCC cells. METHODS: The human OSCC-derived cell lines SCC9 and SCC4 were treated with human recombinant leptin and exposed to 6Gy of irradiation...
October 5, 2018: Journal of Oral Pathology & Medicine
Sana Maher Aghbari, Shaimaa Omar Zayed, Olfat Gamil Shaker, Abdelrahman Ibrahim Abushouk
BACKGROUND: MicroRNA-27b (miR27b) is a small, non-coding RNA that is involved in physiological keratinocyte differentiation and pathological inflammatory processes. We performed this study to investigate the value of miR27b as a diagnostic marker for oral lichen planus (OLP) and the correlation between CD8 (cytotoxic T-cell marker) and miR27b tissue expression in OLP patients. METHODS: Forty participants (including 20 OLP patients and 20 controls) underwent oral biopsy...
October 1, 2018: Journal of Oral Pathology & Medicine
Xiaojing Liu, Haitao Wu, Ping Huang, Fenghe Zhang
BACKGROUND: To investigate the therapeutic mechanism of the BRD4 inhibitor JQ1 in SACC-83 cells and explore strategies to enhance its therapeutic potential. MATERIAL AND METHODS: SACC-83 cells were used in the experiment. Immunohistochemistry was used to assess BRD4 expression in SACC tissues and corresponding adjacent non-tumor tissues. Cell viability and proliferation were evaluated using the Cell Counting Kit-8 assay. Flow cytometry was used to quantitate apoptosis...
September 30, 2018: Journal of Oral Pathology & Medicine
Bruno Ramos Chrcanovic, Ricardo Santiago Gomez
PURPOSE: To review the clinical and radiographic features of the available data published on adenomatoid odontogenic tumor (AOT) with special emphasis on the comparison of its variants. METHODS: An electronic search was undertaken in July 2018. Eligibility criteria included publications having enough clinical/radiological/histological information to confirm the diagnosis. RESULTS: A total of 436 publications reporting 1558 cases were included, of which 739 follicular, 247 extrafollicular, and 30 peripheral AOTs...
September 26, 2018: Journal of Oral Pathology & Medicine
Mayumi Kamaguchi, Hiroaki Iwata, Toshinari Miyauchi, Hideyuki Ujiie, Inkin Ujiie, Toshifumi Nomura, Noritaka Ohga, Hiroshi Shimizu, Yoshimasa Kitagawa
BACKGROUND: Mucous membrane pemphigoid (MMP) is a rare chronic autoimmune subepithelial blistering disorder, targeting multiple basement membrane zone (BMZ) proteins including collagen XVII (COL17). Circulating autoantibodies of MMP are often undetected due to their lower titers. The oral mucosa is a valuable substrate for the detection of autoantibodies in MMP patients. However, obtaining normal human oral mucosa is more difficult than obtaining normal human skin. We established immortalized normal human oral mucosal keratinocytes (OMKs) and performed immunoblotting using immortalized OMK lysate for detecting autoantigens in MMP...
September 17, 2018: Journal of Oral Pathology & Medicine
Gwendolyn Huang, Lynette Moore, Richard M Logan, Sumant Gue
BACKGROUND: Dentigerous cysts are usually of developmental nature but may be of inflammatory origin especially in paediatric populations. It is important to understand the histological features of dentigerous cysts to enable accurate diagnosis. The aim of this study is to present epidemiological, clinical features and histopathological features of dentigerous cysts seen in a paediatric tertiary-referral hospital. METHOD: The medical, radiographic and histopathology records of the Department of Pathology, Women's and Children's Hospital, Adelaide, Australia during January 1998 to December 2013 were reviewed for patients with dentigerous cysts...
September 3, 2018: Journal of Oral Pathology & Medicine
Ben Peacock, Alice Rigby, James Bradford, Ryan Pink, Keith Hunter, Daniel Lambert, Stuart Hunt
BACKGROUND: The incidence of human papilloma virus positive (HPV+ ) oropharyngeal squamous cell carcinoma (OPSCC) has increased rapidly in recent decades. These tumours have a favourable outcome compared to HPV-negative (HPV- ) OPSCC. However, HPV+ tumours are more likely to metastasise to distant sites, suggesting a difference in how these tumour subtypes interact with the metastatic niche. Extracellular vesicles (EVs) have emerged as important players in cell-to-cell communication and are a potential source of biomarkers for cancer diagnosis...
November 2018: Journal of Oral Pathology & Medicine
X J David Lu, Kelly Y P Liu, Rosilene C Soares, Thomas Thomson, Eitan Prisman, Jonn Wu, Catherine F Poh
BACKGROUND: There is increasing evidence that high-risk human papillomavirus plays significant role in oropharyngeal cancer; however, there is lack of knowledge on the interplay between the virus and its downstream-related molecules and their possible prognostic values. The objectives of the study are to better understand the interplay of the HR-HPV and its associated downstream molecules and to evaluate potential biomarkers for patient outcomes. METHODS: We conducted a retrospective study with available formalin-fixed, paraffin-embedded tissue from 244 oropharyngeal cancer patients that received curative radiotherapy or concurrent chemoradiotherapy from 2000 to 2008...
November 2018: Journal of Oral Pathology & Medicine
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