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Journal of Oral Pathology & Medicine

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https://www.readbyqxmd.com/read/28199754/multinucleated-giant-cell-reaction-in-lower-lip-squamous-cell-carcinoma-a-clinical-morphological-and-immunohistochemical-study
#1
Hellen Bandeira de Pontes Santos, Márcia Cristina da Costa Miguel, Leão Pereira Pinto, Manuel Antonio Gordón-Núñez, Pollianna Muniz Alves, Cassiano Francisco Weege Nonaka
BACKGROUND: Multinucleated giant cell (MGC) reactions have been identified in several malignancies, but their frequency and significance in lower lip squamous cell carcinoma (SCC) are not established. This study evaluated the MGC reactions and their association with clinicopathological parameters in lower lip SCCs. The polarization profile of these cells (M1 or M2 macrophages) was also assessed. METHODS: The presence and distribution of MGC reactions in high-power fields (400×) were evaluated in hematoxylin/eosin-stained histological sections of 91 lower lip SCCs...
February 15, 2017: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/28199753/tnf-%C3%AE-308g-a-and-tnf-r1-36a-g-single-nucleotide-polymorphisms-are-strong-risk-factors-for-odontogenic-keratocystic-tumor-development
#2
Branislav Ilic, Nadja Nikolic, Miroslav Andric, Drago Jelovac, Biljana Milicic, Tanja Jozic, Slobodan Krstic, Jelena Milasin
BACKGROUND: Polymorphisms in genes encoding tumor necrosis factor α (TNF α) and its receptor TNF-R1, have been shown to affect one person's susceptibility to develop certain neoplastic diseases. The aim of the present association study was to investigate whether single nucleotide polymorphisms (SNPs) in TNF α (-308G>A) and TNF-R1 (36A>G) genes modulate the susceptibility for keratocystic odontogenic tumors (KCOTs) development in Serbian patients. METHODS: Genotyping was done in 60 KCOT patients and 125 healthy individuals, using polymerase chain reaction/restriction fragment length polymorphism analysis...
February 15, 2017: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/28199744/buccal-films-as-a-dressing-for-the-treatment-of-aphthous-lesions
#3
Zdeněk Daněk, Jan Gajdziok, Petr Doležel, Hana Landová, David Vetchý, Jan Štembírek
BACKGROUND: Buccal flexible films in the form of solid, thin, mucoadhesive patches can be used as dressings separating aphthous lesions from the environment of the oral cavity, which can in turn shorten the treatment period and reduce the pain perception. METHODS: The clinical study was performed on 36 volunteers suffering from aphthous lesions. The first group was treated using standard means - by application of an oral gel containing cholin salicylas (Mundisal) on the aphthous lesion...
February 15, 2017: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/28186659/is-chronic-ulcerative-stomatitis-a-variant-of-lichen-planus-or-a-distinct-disease
#4
REVIEW
Liviu Feller, Razia A G Khammissa, Johan Lemmer
Chronic ulcerative stomatitis is an immune-mediated mucocutaneous disorder characterized clinically by erosions or ulcers. Most cases are limited to the mouth. The histopathological features are non-specific or mimic those of oral lichen planus, and studies by immunoflorescent microscopy are essential for definitive diagnosis. The defining immunopathogenic mechanism is the binding of IgG to the nuclear protein deltaNp63alpha of keratinocytes in the basal and parabasal cell layers of the oral stratified epithelium...
February 10, 2017: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/28186650/p16-and-p53-in-hpv-positive-versus-hpv-negative-oral-squamous-cell-carcinoma-oscc-do-pathways-differ
#5
Vineeta Singh, Nuzhat Husain, Naseem Akhtar, M Y Khan, Abhinav A Sonkar, Vijay Kumar
BACKGROUND: p16 overexpression and wild-type p53 expression is associated with human papilloma virus (HPV) in cervical and oropharyngeal cancer. Role of HPV-related carcinogenesis in the etiology of oral squamous cell carcinoma (OSCC) is still vague in Indian population. We aimed to explore the expression pattern of p16 and p53 in HPV positive and HPV negative OSCC to elicit differences, if any. Further their effect on survival of patients was studied. METHODS: Thirty-one consecutive HPV positive as well as 31 age and sex matched HPV negative OSCC cases from a case series of 369 histologically diagnosed cases of OSCC were included in this study...
February 10, 2017: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/28178760/histone-deacetylase-7-silencing-induces-apoptosis-and-autophagy-in-salivary-mucoepidermoid-carcinoma-cells
#6
Mee-Young Ahn, Jung-Hoon Yoon
BACKGROUND: The overexpression of histone deacetylases (HDACs) has been observed in many cancers and inhibition of specific HDACs has emerged as a new target for cancer therapy. We found that HDAC7 expression was selectively reduced by HDAC inhibitor apicidin in salivary mucoepidermoid carcinoma (MEC) cells. Here, we show that HDAC7 suppression has a potent anti-tumor effect in MEC cells. METHODS: HDAC7 was knocked down using HDAC7 siRNAs and cell proliferation was quantified...
February 8, 2017: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/28178758/incidence-of-lip-malignancies-in-germany-data-from-9-population-based-cancer-registries
#7
S Singer, S R Zeissig, K Emrich, B Holleczek, K Kraywinkel, M Ressing
BACKGROUND: The objective of this study was to analyse the incidence of lip malignancies in Germany. METHODS: Data from population-based cancer registries covering a population of 39 million inhabitants from 14 federal states were pooled. Lip malignancies were classified according to the International Classification of Diseases (ICD-10). Age-standardised incidence rates and annual percentage changes in the incidence trends of lip cancer (C00), melanoma of the lip (C43...
February 8, 2017: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/28161900/reduced-chromatin-acetylation-of-malignant-salivary-gland-tumors-correlates-with-enhanced-proliferation
#8
Vivian Petersen Wagner, Manoela Domingues Martins, Douglas Magno Guimaraes, Artur Cunha Vasconcelos, Luise Meurer, Pablo Agustin Vargas, Felipe Paiva Fonseca, Cristiane Helena Squarize, Rogerio Moraes Castilho
BACKGROUND: Epigenetic changes refer to any heritable modification in gene expression independent of alterations in the DNA sequence. Currently, it is well established that epigenetics represents a crucial player for tumor development. Nevertheless, the epigenetic mechanisms involved in the development and progression of salivary gland tumors (SGTs) remain poorly understood. METHODS: In the present study, we analyzed the pattern of acetyl-histone H3 (lys9) expression in benign and malignant SGTs and further correlate our results with tumors' proliferative activity and clinical outcomes...
February 4, 2017: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/28161894/mediator-of-dna-damage-checkpoint-protein-1-mdc1-as-a-prognostic-marker-for-patients-with-oral-squamous-cell-carcinoma
#9
Jigna Harshadbhai Dave, Hemangini Hasit Vora, Nandita Radhabinod Ghosh, Trupti Indravadan Trivedi
BACKGROUND: The mediator of DNA damage checkpoint protein 1 (MDC1) is involved in the regulation of cell cycle check points and recruitment of several repair proteins to the site of DNA double stranded breaks (DSBs). The present study aims to correlate the expression of MDC1 protein with clinicopathological parameters and to evaluate its prognostic significance in patients with oral squamous cell carcinoma (OSCC). METHODS: MDC1 protein expression was evaluated immunohistochemically from untreated 100 patients with OSCC using modified H-score method...
February 4, 2017: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/28140483/current-update-on-the-diagnosis-and-management-of-head-and-neck-soft-tissue-sarcomas
#10
REVIEW
Ben Tudor-Green, Ricardo Gomez, Peter A Brennan
Head and neck soft tissue sarcomas are a group of rare heterogeneous tumours arising from embryonic mesoderm. They comprise less than 1% of all head and neck malignancies and 5-15% of all sarcomas with most head and neck sarcomas arising from soft tissues. Although rare, they are associated with both high recurrence and mortality rates. We review the current management of head and neck soft tissue sarcomas. This article is protected by copyright. All rights reserved.
January 31, 2017: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/28140481/phenotypic-characterization-of-oral-mucosa-what-is-normal
#11
Jaroslav Valach, René Foltán, Marek Vlk, Pavol Szabo, Karel Smetana
BACKGROUND: Knowledge of the phenotypic pattern of oral squamous epithelium is important in the histopathologic evaluation of lesions including cancer. The literature on normal epithelium is controversial as the phenotype has not been evaluated in samples from completely healthy tissue donors without a history of tobacco and alcohol exposure. METHODS: In this study, we evaluated normal upper lip fornix and gingival mucosa from carefully selected young healthy donors without a history of smoking and alcohol exposure, and keratin types 8, 10, 14, and 17, filaggrin, and Ki67 were investigated in these donors...
January 31, 2017: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/28135012/dna-ploidy-and-cell-cycle-protein-expression-in-oral-squamous-cell-carcinomas-with-and-without-lymph-node-metastases
#12
Ibtisam M Zargoun, L Bingle, P M Speight
BACKGROUND: Oral squamous cell carcinoma (OSCC) is the most frequently occurring malignant tumour in the oral cavity. OSCC arises because of multiple genetic alterations. Cell cycle aberrations and aneuploidy are reportedly among the main characteristics of cancer cells and are associated with aggressive growth and poor prognosis. METHODS: The study sample included 47 non-metastasised and 39 metastasised primary OSCC, with matched positive cervical lymph nodes and 17 normal oral mucosa samples...
January 30, 2017: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/28129456/oral-squamous-cell-carcinoma-in-the-background-of-oral-submucous-fibrosis-is-a-distinct-clinico-pathological-entity-with-better-prognosis
#13
Amol Ramchandra Gadbail, Minal Chaudhary, Madhuri Gawande, Alka Hande, Sachin Sarode, Satyjit Ashok Tekade, Sheetal Korde, Prajakta Zade, Rahul Bhowate, Rajiv Borle, Swati Patil
BACKGROUND: The aim of this study was to compare the clinicopathological features of oral squamous cell carcinoma in the background of oral submucous fibrosis (OSCC-OSMF) and oral squamous cell carcinoma (OSCC). METHODS: 217 cases of OSCC were retrieved from achieves for the analysis.OSCC-OSMF cases were segregated on the basis of history and clinico-pathological parameters. RESULTS: The study included 217 patients of which 112 had OSCC and 105 OSCC-OSMF...
January 27, 2017: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/28122164/increased-circulating-cxcr5-cd4-t-follicular-helper-like-cells-in-oral-lichen-planus
#14
Ya-Qin Tan, Qing Li, Jing Zhang, Ge-Fei Du, Rui Lu, Gang Zhou
BACKGROUND: CD4(+) T helper cell is crucial for the inflammatory autoimmune condition of oral lichen planus (OLP). Recently, the pathogenetic functions of T follicular helper (Tfh) cells, a subtype of CD4(+) T helper cells, has been revealed in autoimmune diseases for their pivotal regulation on humoral immunity. To explore the potential pathophysiological role of Tfh cells in OLP, the expression of circulating Tfh-like cells and its correlations with IL-21 and B cells were investigated...
January 25, 2017: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/28122153/oral-cancer-screening-for-high-risk-individuals-in-the-primary-health-care-setting-using-an-active-approach
#15
Allana Pivovar, Zilá Ferreira Dias Gonçalves Dos Santos, Cassius Carvalho Torres-Pereira
BACKGROUND: Oral squamous cell carcinoma (OSCC) is considered a major public health problem. The diagnosis often occurs in advanced stages, causing high morbidity and mortality and therefore prevention strategies should be advocated. This study aims to investigate a model of OSCC screening for high-risk individuals in the Family Health Strategy's (FHS) scenario. METHODS: Participants were men between 50 and 65 years of age registered in a primary health care electronic database and resident in an area with low socioeconomic status in the city of Curitiba (Paraná/Brazil)...
January 25, 2017: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/28122142/dysregulation-of-akt1-a-mir-138-target-gene-is-involved-in-the-migration-and-invasion-of-tongue-squamous-cell-carcinoma
#16
Muyuan Ji, Wei Wang, Wangxiang Yan, Dan Chen, Xueqiang Ding, Anxun Wang
BACKGROUND: AKT1, also known as PKBα, is abnormally expressed in various malignancies. In this study, we aimed to evaluate the role of AKT1 in the tongue squamous cell carcinoma (TSCC) and further clarify the mechanisms of AKT1 in the migration and invasion of TSCC. METHODS: At first, immunohistochemistry (IHC) was conducted to detect the expression of AKT1 in TSCC. Then, we determined the role of AKT1 in the migration and invasion of TSCC and further investigated whether AKT1 was the target gene of miR-138 by using dual luciferase reporter assays and western blot...
January 25, 2017: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/28075506/efficacy-of-chlorhexidine-for-the-prevention-and-treatment-of-oral-mucositis-in-cancer-patients-a-systematic-review-with-meta-analyses
#17
REVIEW
Alvin Cardona, Amir Balouch, Moiz Mohammed Abdul, Parish P Sedghizadeh, Reyes Enciso
BACKGROUND: Oral mucositis occurs in patients undergoing chemoradiation for cancer treatment. It is believed that colonization of ulcerated mucosa by bacteria, fungi, and virus results in secondary infections. The effect of chlorhexidine on the incidence and severity of oral mucositis in patients with cancer was evaluated in this review. METHODS: Studies were limited to randomized placebo-controlled trials. Three databases were searched: MEDLINE (via PubMed), Web of Science, and the Cochrane Library up to May 25, 2016...
January 11, 2017: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/28063153/volumetric-assessment-of-alveolar-clefts-a-literature-review
#18
REVIEW
João Batista Blessmann Weber, Luciane de Macedo Menezes, Fabiane Azeredo, Luciano Schwartz Lessa Filho
OBJECTIVE: To conduct a review of the literature on methods for volumetric assessment of alveolar clefts and ascertain which methods are most precise to guide future research. METHODS: The PubMed and MEDLINE databases were searched for English-language reports of clinical and in vitro studies with detailed descriptions of imaging modality, sample characteristics, and method for measurement of alveolar cleft volume. RESULTS: The search strategy yielded 34 articles, of which 14 were selected for in-depth analysis...
January 7, 2017: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/28054399/comparison-of-effects-of-zoledronic-acid-and-clodronate-on-the-bone-structure-imaginological-and-histomorphometrical-study-in-vivo
#19
Stephanie Joana Roman Martelli, Melissa Feres Damian, Ana Paula Neutzling Gomes, André Ribeiro Schinestsck, Alexandre Emídio Ribeiro Silva, Ana Carolina Uchoa Vasconcelos
OBJECTIVES: To compare histologically and imaginologically the bone structure of rats' mandibles treated with bisphosphonates (BPs) and rats that did not receive BPs. METHODS: Thirty-four rat specimens (Rattus novergicus, Wistar strain) were divided into three groups: (i) 12 rats treated with zoledronic acid; (ii) 12 rats treated with clodronate; and (iii) the control group, containing 10 rats that received saline solution. All individuals were exposed to cone beam computed tomography (CBCT)...
January 5, 2017: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/28054386/enzymatic-antioxidants-status-in-patients-with-recurrent-aphthous-stomatitis
#20
Zichuan Zhang, Shan Li, Huiqing Fang
BACKGROUND: Oxidative stress (OS) has been thought to play a main role in the etiopathogenesis of recurrent aphthous stomatitis (RAS), which is one of the most common oral mucosal diseases characterized by recurrent and painful oral ulcers. The aim of this investigation was to evaluate the enzymatic antioxidants status in patients with RAS in the active stage and remission stage. METHODS: Ninety-seven patients with idiopathic minor RAS and 102 race-, age- and gender-matched healthy individuals were recruited...
January 5, 2017: Journal of Oral Pathology & Medicine
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