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Journal of Oral Pathology & Medicine

Lili Wei, Haofei Xiong, Wei Li, Bo Li, Yong Cheng
BACKGROUND: The human salivary gland cell line (HSG) has so far been used as in vitro models for study of the influence of cytokines and pharmacologic agents on salivary glands, as well as a model system for inflammation in Sjögren's syndrome (SS). This study aimed to determine the effect of IL-17 on IL-6 production and the underlying molecular mechanism regulated by the HSG cell line. METHODS: Immunofluorescence analyses, RT-PCR, and Western blot were conducted to evaluate the IL-17 receptor (IL-17R) expression in cultured HSG cells...
July 14, 2018: Journal of Oral Pathology & Medicine
Ahoud Jazzar, Penelope J Shirlaw, Guy H Carpenter, Stephen J Challacombe, Gordon B Proctor
BACKGROUND: Sjögren's syndrome (SS) is an autoimmune inflammatory disease that affects the exocrine glands. The absence of early diagnostic markers contributes to delays in its diagnosis. Identification of changes in the protein profile of saliva is considered one of the promising strategies for the discovery of new biomarkers for SS. OBJECTIVE: To identify salivary protein biomarkers with potential for use in discriminating between different lymphoma risk sub-groups of SS...
July 12, 2018: Journal of Oral Pathology & Medicine
Jian-Lin Liu, An-Qi Zhang, Li-Cheng Jiang, Ke-Yi Li, Feng-Zhen Liu, Dao-Ying Yuan, Kai Xu, Qing-Chun Fan, Xian-Bin Liu, Bo Zou, Zheng Meng, Yuan Feng, Bin Zhang
OBJECTIVES: Mucocele of the minor salivary gland is usually caused when the duct is injured, mucus leaks into the tissue space and the mucous gland is obstructed, which leads to cystic lesion formation and dilatation. Currently, there are multiple therapeutic methods available with various outcomes. This study aims to provide clinical evidence of polidocanol sclerotherapy for the treatment of mucocele of the minor salivary gland. METHODS: In this study, we injected polidocanol into 112 patients who were diagnosed with mucocele of the minor salivary gland and evaluated the treatment efficacy and safety systematically...
July 12, 2018: Journal of Oral Pathology & Medicine
Zinan Yang, Kan Li, Qian Liang, Guangsen Zheng, Sien Zhang, Xiaomei Lao, Yujie Liang, Guiqing Liao
BACKGROUND: The process of marsupialization involves the release of intracystic pressure and the fluid contained within. Marsupialization of cystic ameloblastoma is controversial; therefore, we investigated how hydrostatic pressure influences biological behaviours of ameloblastoma cells and its underlying mechanisms. MATERIALS AND METHODS: An ameloblastoma epithelial cell line, hTERT+ -AM, was exposed to different hydrostatic pressures with or without Dickkopf-related protein 1 (also known as DKK), a canonical Wnt signalling pathway inhibitor...
July 2, 2018: Journal of Oral Pathology & Medicine
Ricardo Natã Fonseca Silva, Laís Bueno Dallarmi, Ana Karoline Carvalho Araujo, Rita Cassia Alencar, Elismauro Francisco Mendonça, Tarcília Aparecida Silva, Aline Carvalho Batista, Nadia Lago Costa
BACKGROUND: Tumor-associated neutrophils (TAN), matrix metalloproteinase-9 (MMP-9), interleukin-17 (IL-17), and angiogenesis have been proposed as prognostic biomarkers of malignant tumors. The purpose of this study is to investigate these inflammatory markers as prognostic factors for oral squamous cell carcinoma (OSCC). METHODS: Specimens of OSCC (n = 30), healthy oral mucosa (negative control, n = 10), oral leukoplakia (n=10) and apical granuloma with abscess (positive inflammatory controls, n = 10) were immunostained for CD66b (neutrophils), MMP-9, IL-17, and CD105 (neoformed microvessels)...
July 2, 2018: Journal of Oral Pathology & Medicine
Yuxian Song, Qian Zhou, Huidong Zhu, Yue Jing, Xiaoxin Zhang, Yan Yang, Qingang Hu, Xiaofeng Huang, Yanhong Ni
BACKGROUND: Monocytes, which subdivided into three functional subsets (classical, intermediate, and nonclassical), play important roles in the progression of cancer. The subset composition is altered in several pathologic conditions including cancers. However, the composition and function of circulating monocyte subsets in patients with oral squamous cell carcinoma (OSCC) are still obscure. METHODS: The frequencies of monocyte subsets in peripheral blood of OSCC patients and healthy donors are determined by flow cytometry, and their diagnostic values for OSCC were evaluated...
July 1, 2018: Journal of Oral Pathology & Medicine
Abdulhameed Alsarraf, Omar Kujan, Camile S Farah
OBJECTIVES: This study aims to develop diagnostic criteria to identify oral squamous cell carcinoma (OSCC) and oral potentially malignant disorders (OPMDs) using oral liquid-based brush cytology (OLBC), and to compare its accuracy with the gold standard of surgical biopsy and histopathological diagnosis of oral leukoplakia. METHODS: A total number of 134 samples were collected. All patients underwent Orcellex® brush biopsy with liquid-based cytology immediately prior to diagnostic surgical biopsy...
June 29, 2018: Journal of Oral Pathology & Medicine
Chunyu Chen, Qiang Guo, Jinna Shi, Xiaohui Jiao, Kewen Lv, Xiaotong Liu, Yuxin Jiang, Xiang Hui, Tao Song
BACKGROUND: The role of underlying genetic factors in the pathogenesis of nonsyndromic orofacial clefts (NSOC) remains poorly understood. Although genome-wide association studies (GWASs) of NSOC have successfully identified a large number of novel genetic risk loci, association results of replication studies are inconsistent across different populations. METHODS: Six single-nucleotide polymorphisms (SNPs) (rs7922405 at 10q26.3, rs7303 9426 at 19q13.11, rs7552 at 2p24...
June 27, 2018: Journal of Oral Pathology & Medicine
Luana Samara Balduíno de Sena, Éricka Janine Dantas da Silveira, Aline Carvalho Batista, Elismauro Francisco de Mendonça, Pollianna Muniz Alves, Cassiano Francisco Weege Nonaka
BACKGROUND: Actinic cheilitis (AC) is a potentially malignant disorder that can progress to squamous cell carcinoma (SCC), but this process is not fully understood. This study evaluated the immunoexpression of glucocorticoid receptor alpha isoform (GRα) and apoptotic proteins (BCL-2 and BAX) in AC and lower lip SCC (LLSCC). METHODS: Twenty-two ACs and 44 LLSCCs (22 with regional nodal metastasis and 22 without metastasis) were selected. The percentages of nuclear (GRα) and cytoplasmic (GRα, Bcl-2, and Bax) staining in epithelial cells were assessed and correlated with clinical (tumor size/extent and clinical stage) and histopathological parameters (risk of malignant transformation for ACs and histopathological grade of malignancy for LLSCCs)...
June 23, 2018: Journal of Oral Pathology & Medicine
Keiko Aota, Tomoko Yamanoi, Koichi Kani, Koh-Ichi Nakashiro, Naozumi Ishimaru, Masayuki Azuma
BACKGROUND: Mechanisms underlying immune cells' recruitment and activation into the inflammatory lesions of lip salivary glands (LSGs) from primary Sjögren's syndrome (pSS) patients are incompletely understood. Chemokines play pivotal roles in these processes, so we investigated the clinical significance of chemokine receptor CXCR3 and its ligands in the autoimmune lesions of pSS. METHODS: We histologically determined the grade of LSG samples from 22 pSS patients and subjected the samples to immunofluorescence analysis to determine the expressions of CXCR3 and its ligands: CXCL9, CXCL10, and CXCL11...
June 21, 2018: Journal of Oral Pathology & Medicine
In-Hyoung Yang, Won Jung, Lee-Han Kim, Ji-Ae Shin, Nam-Pyo Cho, Seong Doo Hong, Kyoung-Ok Hong, Sung-Dae Cho
BACKGROUND: We have shown previously that nitidine chloride (NC) induces apoptosis via inhibition of signal transducer and activator of transcription 3 (STAT3). However, its downstream molecules are not fully understood yet. Here we report that NC as STAT3 inhibitor down-regulates myeloid cell leukemia-1 (Mcl-1) protein in HSC-3 and HSC-4 human oral squamous cell carcinoma (OSCC) cells and a nude mouse tumor xenograft model. METHODS: This study investigated the effects of NC on Mcl-1 expression in HSC-3 and HSC-4 cells using Western blotting, RT-PCR, and Dual-luciferase assay...
June 20, 2018: Journal of Oral Pathology & Medicine
Carla Isabelly Rodrigues-Fernandes, Lucas Lacerda de Souza, Sara Ferreira Dos Santos-Costa, André Myller Barbosa Silva, Hélder Antônio Rebelo Pontes, Márcio Ajudarte Lopes, Oslei Paes de Almeida, Peter A Brennan, Felipe Paiva Fonseca
BACKGROUND: Plasmablastic lymphoma (PBL) is a high-grade lymphoma that often affects the oral cavity of HIV-positive patients; however, its prognostic determinants remain unknown. PURPOSE: To integrate the available data on oral PBL to determine its clinicopathological features and to identify potential prognostic factors. METHODS: An electronic systematic review was performed using multiple databases with a specific search strategy in February 2018...
June 19, 2018: Journal of Oral Pathology & Medicine
Shailesh M Gondivkar, Sachin C Sarode, Amol R Gadbail, Rima S Gondivkar, Revant Chole, Gargi S Sarode
BACKGROUND: Citation analysis reflects the scientific recognition and influential performance of an article in the scientific community. The objective of this study was to identify and characterize the 100 most cited articles on oral submucous fibrosis (OSF). METHODS: A list of 100 most cited articles related to OSF was retrieved from the Science Citation Index-Expanded tool of Scopus database in May 2018.The articles were further reviewed, and basic information was recorded including the number of citations, citation density, journals, with its impact factor, category and quartile, publication year, authors, institution and country of origin, article type and level of evidence...
June 15, 2018: Journal of Oral Pathology & Medicine
Chit Cheng Yeoh, Nedal Dabab, Elyse Rigby, Ritu Chhikara, Iolia Akaev, Ricardo Santiago Gomez, Felipe Fonseca, Peter A Brennan, Siavash Rahimi
The role of the androgen receptor (AR) as an immunomarker for diagnosis of salivary gland duct carcinoma (SDC) is well known. Other non-squamous cell head and neck cancers (NSCC-HN), including a small subset of salivary gland cancers (SGCs), can also express AR. With the increase in effective and powerful new generation of anti-androgen agents and drugs administered orally, more targetable AR-driven NSCC-HN, such as subsets of SGCs, should be investigated for possible expression of AR. In this review, we focus on SGC subtypes, which could express AR and describe the main androgen deprivation therapy (ADT) strategies...
June 4, 2018: Journal of Oral Pathology & Medicine
Bogahawatte Samarakoon Mudiyanselage Samadarani Siriwardena, Tennakoon Mudiyanselage Priyanka Bandara Tennakoon, Keith D Hunter, Wanninayake Mudiyanselage Tilakaratne
BACKGROUND: Unicystic ameloblastoma (UA) is a variant of ameloblastoma that has a relatively benign biologic behavior and mostly occurs in a younger age group. The entire cystic lining of unicystic ameloblastoma may not always be uniformly characteristic and may partly consist of non-specific epithelium or dentigerous cyst-like lining. The variability seen reinforces the advice that multiple biopsies should be taken from large cystic lesions to represent the entire lesion. METHODS: All cases were retrieved from the archives of our unit from 1986 to 2016...
June 2, 2018: Journal of Oral Pathology & Medicine
Kelsey M Hirschi, Steven Chapman, Parker Hall, Adam Ostergar, Duane R Winden, Paul R Reynolds, Juan A Arroyo
BACKGROUND: Gas6 protein is involved in the progression of cancers and has been demonstrated to have a role in inflammation. Oral squamous cell carcinoma is a common form of oral cancer, and it commonly expresses Gas6. Our objective was to determine the effects of Gas6 on oral squamous cell carcinoma invasion and identify signaling molecules and cytokines associated with Gas6-mediated invasion. METHODS: Ca9-22 cells were cultured in the presence or absence of Gas6...
June 1, 2018: Journal of Oral Pathology & Medicine
Rawen Smirani, Marie-Elise Truchetet, Nicolas Poursac, Adrien Naveau, Thierry Schaeverbeke, Raphaël Devillard
BACKGROUND: Oropharyngeal features are frequent and often understated in the treatment clinical guidelines of systemic sclerosis in spite of important consequences on comfort, aesthetics, nutrition and daily life. The aim of this systematic review was to assess a correlation between the oropharyngeal manifestations of systemic sclerosis and patients' health-related quality of life. METHODS: A systematic search was conducted using four databases [PubMed® , Cochrane Database® , Dentistry & Oral Sciences Source® and SCOPUS® ] up to January 2018, according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses...
June 1, 2018: Journal of Oral Pathology & Medicine
Meri Sieviläinen, Fabricio Passador-Santos, Rabeia Almahmoudi, Solomon Christopher, Maria Siponen, Sanna Toppila-Salmi, Tuula Salo, Ahmed Al-Samadi
BACKGROUND: Oral mucosal dysplasia is a histologic feature of potentially malignant disorders that is associated with the risk of transformation to carcinoma. Dysplastic cells use many strategies during their transformation to cancer, including escape from the immune mediated destruction. We hypothesized that adaptive immunity is inhibited by activation of distinct immune checkpoint molecules, such as indoleamine 2,3-dioxygenase 1 (IDO1) and programmed death-ligand 1 (PD-L1). METHODS: We collected 63 oral dysplasia samples from 47 patients...
May 30, 2018: Journal of Oral Pathology & Medicine
Wilfredo A González-Arriagada, Carlos Lozano-Burgos, Rodrigo Zúñiga-Moreta, Paulina González-Díaz, Ricardo D Coletta
BACKGROUND: Head and neck squamous cell carcinoma shows high prevalence of lymph node metastasis at diagnosis, and despite the advances in treatment, the overall 5-year survival is still under 50%. Chemokine receptors have a role in the development and progression of cancer, but their effect in head and neck carcinoma remains poorly characterised. This study aimed to assess the prognostic value of CCR1, CCR3, CCR4, CCR5, CCR7 and CXCR4 in head and neck squamous cell carcinomas. METHODS: Immunohistochemical expression of chemokine receptors was evaluated in a retrospective cohort of 76 cases of head and neck squamous cell carcinoma...
May 24, 2018: Journal of Oral Pathology & Medicine
Rafael C Ortiz, Nathália M Lopes, Nádia G Amôr, José B Ponce, Cláudia K Schmerling, Vanessa S Lara, Raquel A Moyses, Camila O Rodini
BACKGROUND: Tumour metastasis has been associated with cancer stem cells, a small population with stem-like cells properties, higher rate of migration and metastatic potential compared to cells from the tumour bulk. Our aim was to evaluate the immunoexpression of the putative cancer stem cell biomarkers ALDH1 and CD44 in primary tumour and corresponding metastatic lymph nodes. METHODS: Tumour tissue specimens (n = 50) and corresponding metastatic lymph nodes (n = 25) were surgically obtained from 50 patients with oral squamous cell carcinoma and submitted to immunohistochemistry...
May 23, 2018: Journal of Oral Pathology & Medicine
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