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Journal of Oral Pathology & Medicine

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https://www.readbyqxmd.com/read/28922483/molecular-basis-of-oral-squamous-cell-carcinoma-in-young-patients-is-it-any-different-from-older-patients
#1
REVIEW
Sara Ferreira Dos Santos Costa, Peter A Brennan, Ricardo Santiago Gomez, Eduardo Rodrigues Fregnani, Alan Roger Santos-Silva, Manoela Domingues Martins, Gilberto de Castro-Junior, Siavash Rahimi, Felipe Paiva Fonseca
Oral squamous cell carcinoma (OSCC) is the commonest subtype of oral cancer, mainly affecting older patients. It used to be a rare disease among individuals younger than 40 years, but recently increased incidences in this age group are being reported worldwide. The pathogenesis of OSCC affecting young patients remains controversial and the well known etiological factors for oral cancer, tobacco and alcohol use, are believed to play a minor role in the carcinogenesis of the neoplasm, suggesting that the etiology and the molecular basis of OSCC may differ between younger and older patients...
September 18, 2017: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/28891106/treatment-resistance-in-potentially-malignant-disorders-nature-or-nurture-%C3%A2
#2
P J Thomson, M L Goodson, D R Smith
BACKGROUND: Contemporary potentially malignant disorder management is based upon provisional histological diagnosis followed by interventional surgery to excise or ablate 'high risk' mucosal lesions. Although the majority of patients achieve disease free status post-treatment, others develop further or persistent disease unresponsive to intervention. METHODS: A detailed, retrospective clinico-pathological review of treatment resistant potentially malignant lesions, from a 590 patient cohort treated by CO2 laser surgery and followed for a mean of 7...
September 11, 2017: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/28865104/developing-a-quality-of-life-questionnaire-for-oral-submucous-fibrosis-patients
#3
LETTER
Arpita Rai
I would like to congratulate the authors for an informative article titled - Impact of Oral Potentially Malignant Disorders on Quality of Life, by Tadakamadala et al(1) , which was an interesting read. The authors have included 50 patients each of Oral Leukoplakia (OL), Oral Lichen Planus (OLP) and Oral Submucous Fibrosis (OSF) who were administered Oral potentially malignant disorders quality of life (OPMDQoL) questionnaire and a short form 12 item (version 2) health survey questionnaire (SF-12v2). The authors concluded that OLP and OSF have a significant impact on the quality of life (QoL) of affected individuals especially in the domains 'Physical impairment and functional limitations' and increasing stage of the disease is associated with worsening QoL...
September 2, 2017: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/28865083/radiation-induced-changes-in-the-microstructure-of-epithelial-cells-of-the-oral-mucosa-a-comparative-light-and-electron-microscopic-study
#4
Pekka J Asikainen, Hannah Dekker, Ellinoora Sirviö, Jopi Mikkonen, Engelbert A J M Schulten, Elisabeth Bloemena, Arto Koistinen, Chris M Ten Bruggenkate, Arja M Kullaa
OBJECTIVES: The microplicae is a typical structure of the epithelial cell surface of the oral mucosa. The cell surface is potentially of great significance, as it provides the underlying basis for the protective function of the salivary pellicle. The aim of this study is to investigate whether radiation therapy affects the surface morphology of the superficial cells of the human oral mucosa in patients who have received radiotherapy for oral cancer. MATERIAL AND METHODS: Oral mucosal tissue samples from 91 patients were collected during dental implant surgery or ablative surgery...
September 2, 2017: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/28865081/chronic-treatment-with-zoledronic-acid-increases-inflammatory-markers-in-periodontium-of-rats
#5
Paulo Goberlânio de Barros Silva, Antonio Ernando Carlos Ferreira Junior, Camila Carvalho de Oliveira, Luiz André Cavalcante Brizeno, Deysi Viviana Tenazoa Wong, Roberto César Pereira Lima Júnior, Fabrício Bitú Sousa, Mário Rogério Lima Mota, Ana Paula Negreiros Nunes Alves
BACKGROUND: Bisphosphonates (BF) rises proinflammatory markers and irreversibly binds to bone. Chronically BF can lead to an inflammatory status and can increase the local oxidative stress in periodontium. Therefore, the objective of this study was evaluated if the chronic infusion of Zoledronic Acid (ZA) increases inflammatory markers in periodontium of rats. METHODS AND RESULTS: Chronically infusion therapy was performed with ZA (0.04, 0.2 or 1 mg/kg or saline) by four doses in over a 70-day period to analysis periodontium of the first right inferior molar using histologic, histochemical (toluidine blue) and immunohistochemical (CD68, Tumor Necrosis Factor-α (TNF-α), Interleukin-1beta (IL-1β), Inducible Nitric Oxide Synthase (iNOS) and Nuclear Factor kappa B (NF-kB)) tests...
September 2, 2017: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/28833675/efficacy-of-oral-brush-biopsy-in-potentially-malignant-disorder-management
#6
M L Goodson, D R Smith, P J Thomson
BACKGROUND: Oral potentially malignant disorders (PMD) harbour unpredictable risk for squamous cell carcinoma development. Current management requires tissue biopsy for histopathology characterisation, dysplasia grading and targeted intervention to "high-risk" lesions, although evidence-based guidelines are limited and diagnoses subjective. This study investigated the use of adjunctive oral brush biopsy techniques during the management of PMD in a UK hospital population. METHODS: Retrospective review of a 310 PMD patient cohort presenting to Maxillofacial Surgery in Newcastle upon Tyne with new, single-site lesions between December 2009 and May 2014...
August 21, 2017: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/28833630/potentially-malignant-disorders-the-case-for-intervention
#7
REVIEW
P J Thomson
Potentially malignant disorders are recognisable mucosal conditions preceding invasive squamous carcinoma development. Established oral cancer remains a lethal and deforming disease, with a rising incidence. Management techniques for identifiable oral precursor lesions have traditionally been polarised between observational and interventional surgical techniques. By defining salient management goals for treating potentially malignant disease, and examining the evidence supporting the efficacy of treatment intervention, this paper presents the case for interventional laser surgery as a definitive diagnostic and treatment modality...
August 21, 2017: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/28833670/profiling-cancer-risk-in-oral-potentially-malignant-disorders-a-patient-cohort-study
#8
P J Thomson, M L Goodson, D R Smith
BACKGROUND: Oral potentially malignant disorders harbour variable and unpredictable risk for squamous carcinoma development. Whilst current management strategies utilise histopathological diagnoses, dysplasia grading and targeted intervention for "high-risk" lesions, clinicians are unable to predict malignant potential. METHODS: Detailed, retrospective clinico-pathological analysis of potentially malignant lesions undergoing malignant transformation, from a 590 patient cohort treated by interventional laser surgery and followed for a mean of 7...
August 20, 2017: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/28833597/artepillin-c-as-a-targeting-survivin-molecule-in-oral-squamous-cell-carcinoma-cells-in-vitro-a-preliminary-study
#9
Seokjoon Pang, Michael Yee, Yasmin Saba, Takahiro Chino
BACKGROUND: Survivin, a member of the inhibitor of apoptosis family, is overexpressed in most human tumors, but undetectable in normal adult tissues. It is a promising target molecule in cancer treatment, since interference in its function promotes apoptosis. Artepillin C, a major, biologically active ingredient of Brazilian propolis, possesses anticancer activity against several cancer cells with different tissue origins. However, little is known about its bioactivity on oral squamous cell carcinoma cells or its effect on survivin expression...
August 20, 2017: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/28782893/prognostic-value-of-the-immunohistochemical-detection-of-cancer-associated-fibroblasts-in-oral-cancer-a-systematic-review-and-meta-analysis
#10
REVIEW
Mauricio Rocha Dourado, Eliete N S Guerra, Tuula Salo, Daniel W Lambert, Ricardo D Coletta
AIM: To perform a meta-analysis to assess whether the presence of cancer-associated fibroblasts (CAF) is a prognostic marker of oral squamous cell carcinomas (OSCC). METHODS: Immunohistochemical studies assessing the prognostic relevance of CAF (alpha smooth muscle actin (α-SMA)-positive fibroblasts) in patients with OSCC were systematically reviewed using Cochrane, Lilacs, PubMed, Scopus and Web of Science databases. The outcomes assessed were overall survival (OS) and disease-free survival (DFS)...
August 7, 2017: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/28776760/ameloblastic-fibroma-and-ameloblastic-fibrosarcoma-a-systematic-review
#11
REVIEW
Bruno Ramos Chrcanovic, Peter A Brennan, Siavash Rahimi, Ricardo Santiago Gomez
PURPOSE: To integrate the available data published to date on ameloblastic fibromas (AF) and ameloblastic fibrosarcomas (AFS) into a comprehensive analysis of their clinical/radiological features. METHODS: An electronic search was undertaken in July 2017. Eligibility criteria included publications having enough clinical, radiological and histological information to confirm a definite diagnosis. RESULTS: A total of 244 publications (279 central AF tumours, 10 peripheral AF, 103 AFS) were included...
August 4, 2017: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/28776757/immune-response-of-patients-with-recurrent-aphthous-stomatitis-challenged-with-a-symbiotic
#12
Maria Angela Martins Mimura, Ricardo Carneiro Borra, Cleonice Hitomi Watashi Hirata, Norma de Oliveira Penido
BACKGROUND: There are indications that Th1 polarization of immune response plays an important role in the pathogenesis of Recurrent Aphthous Stomatitis (RAS), and that the use of probiotics can stimulate immune regulatory activity, influencing the course of the disease. The aim of the present study was to characterize the initial immune profile of RAS patients and evaluate clinical and serological response following a challenge with symbiotic treatment containing fructooligosaccharide, Lactobacillus and Bifidobacterium...
August 4, 2017: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/28766765/impact-of-oral-potentially-malignant-disorders-on-quality-of-life
#13
Jyothi Tadakamadla, Santhosh Kumar, Ratilal Lalloo, Gandhi Babu, Newell W Johnson
BACKGROUND: Oral Potentially Malignant Disorders (OPMDs) could have a significant psychological impact on patients, principally because of the unknown risk of malignant transformation, while the physical and functional impairments could differ. This study aimed to assess the impact of three different OPMDs and their disease stages on the Quality of Life (QoL) of affected patients. METHODS: Oral Leukoplakia (OL), Oral Lichen Planus (OLP) and Oral Submucous Fibrosis (OSF) patients who were undergoing treatment at an oral medicine clinic of a dental teaching hospital in India were the study population...
August 2, 2017: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/28766756/efficacy-of-low-level-laser-therapy-compared-to-steroid-therapy-in-the-treatment-of-oral-lichen-planus-a-systematic-review
#14
REVIEW
Zohaib Akram, Tariq Abduljabbar, Fahim Vohra, Fawad Javed
BACKGROUND: Low-level laser therapy (LLLT) has been proposed as a potential treatment strategy for the treatment of oral lichen planus (OLP). The aim of this systematic review was to assess the efficacy of LLLT, in comparison with corticosteroid therapy, in the treatment of OLP. MATERIALS AND METHODS: This systematic review aimed to address the following focused question: "Does LLLT yield better clinical outcomes than corticosteroid therapy in the treatment of OLP?" Indexed databases were searched up to and including April 2017...
August 2, 2017: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/28731540/participation-of-osteoclastogenic-factors-in-immunopathogenesis-of-human-chronic-periapical-lesions
#15
S C L T Santos, L A Couto, J M Fonseca, F C A Xavier, A C L Figueiredo, V S Freitas, R A Freitas, J N Santos, A C G Henriques
BACKGROUND: Chronic periapical lesions (CPLs) are common lesions of the oral cavity and are the result of caries, tooth fracture, iatrogenic causes, or factors causing contamination and pulp necrosis. Inflammatory cells participate in the expansion of CPLs by releasing factors that stimulate or inhibit osteolytic activity. The objective of this study was to investigate the participation of RANKL, TNF-α, cathepsin K, IL-33, and OPG in the development of radicular cysts (RCs) and periapical granulomas (PGs)...
July 21, 2017: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/28730665/is-dna-ploidy-related-to-smoking
#16
Celina Faig Lima, Monica Ghislaine Oliveira Alves, Bruna Fernandes do Carmo Carvalho, Thaynara Alves de Lima, Cláudia Malheiros Coutinho-Camillo, Fernando Augusto Soares, Jaqueline Scholz, Janete Dias Almeida
In the oral cavity, genomic instability is caused by long-term exposure to carcinogens. The aim of the present study was to evaluate the relationship between smoking and DNA ploidy METHODS: Cytological material was obtained from patients participating in the Outpatient Smoking Treatment Program of the Heart Institute (INCOR-HCFMUSP), and of the Discipline of Oral Medicine (ICT-UNESP). The inclusion criteria for all groups were the absence of a history of malignant tumors, absence of clinical signs of changes in the selected area, and alcohol consumption of less than 3 units per week...
July 20, 2017: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/28727172/immunohistochemical-expression-of-myb-in-salivary-gland-basal-cell-adenocarcinoma-and-basal-cell-adenoma
#17
Sydney L Rooney, Robert A Robinson
BACKGROUND: Basal cell predominant salivary gland neoplasms can be difficult to separate histologically. One of the most aggressive of basaloid salivary gland neoplasms is adenoid cystic carcinoma. MYB expression by immunohistochemistry has been documented in adenoid cystic carcinoma. Some investigators have suggested that using this expression can help in establishing the diagnosis of adenoid cystic carcinoma. Utilizing tissue microarrays, we studied a group of basal cell adenocarcinomas and basal cell adenomas to determine: (i) whether either tumor expressed MYB and (ii) the frequency of any expression in either tumors...
July 20, 2017: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/28715092/the-origins-of-oral-medicine-in-the-hippocratic-collected-works
#18
REVIEW
Helen Askitopoulou, Vasileia Nyktari, Alexandra Papaioannou, Georgios Stefanakis, Elina Konsolaki
The collected works of Hippocrates describe for the first time in a systematic way a large number of oral diseases, such as ulcers, inflammations, abscesses and tumours from the epiglottis, mouth, tongue, palate, uvula and the sublingual area. Several of these case reports are remarkable for the accurate observation of clinical symptoms and signs, the aetiology, the pathogenesis and their therapeutic approach in relation to prognosis. The Hippocratic authors report cases of 'aphthae' as part of a polysystemic disease, described many centuries later by Behçet and Adamantiades, while they associate features of splenomegaly from endemic malaria with gingivitis ('ulitis')...
July 17, 2017: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/28691756/surgical-specimen-handover-from-the-operating-theatre-to-laboratory-can-we-improve-patient-safety-by-learning-from-aviation-and-other-high-risk-organisations
#19
Peter A Brennan, Marieke T Brands, Lucy Caldwell, Felipe Paiva Fonseca, Nic Turley, Susie Foley, Siavash Rahimi
Essential communication between healthcare staff is considered one of the key requirements for both safety and quality care when patients are handed over from one clinical area to other. This is particularly important in environments such as the operating theatre and intensive care where mistakes can be devastating. Health care has learned from other high-risk organisations (HRO) such as aviation where the use of checklists and human factors awareness has virtually eliminated human error and mistakes. To our knowledge, little has been published around ways to improve pathology specimen handover following surgery, with pathology request forms often conveying the bare minimum of information to assist the laboratory staff...
July 10, 2017: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/28677249/advances-toward-fully-automated-in-vivo-assessment-of-oral-epithelial-dysplasia-by-nuclear-endomicroscopy-a-pilot-study
#20
Jan Liese, Karsten Winter, Änne Glass, Julia Bertolini, Peer Wolfgang Kämmerer, Bernhard Frerich, Ingolf Schiefke, Torsten W Remmerbach
BACKGROUND: Uncertainties in detection of oral epithelial dysplasia (OED) frequently result from sampling error especially in inflammatory oral lesions. Endomicroscopy allows non-invasive, "en face" imaging of upper oral epithelium, but parameters of OED are unknown. METHODS: Mucosal nuclei were imaged in 34 toluidine blue-stained oral lesions with a commercial endomicroscopy. Histopathological diagnosis showed four biopsies in "dys-/neoplastic," 23 in "inflammatory," and seven in "others" disease groups...
July 4, 2017: Journal of Oral Pathology & Medicine
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