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Journal of Oral Pathology & Medicine

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https://www.readbyqxmd.com/read/28640948/high-level-%C3%AE-iii-tubulin-overexpression-occurs-in-most-head-and-neck-cancers-but-is-unrelated-to-clinical-outcome
#1
Julie C Nienstedt, Alexander Gröbe, Till Clauditz, Ronald Simon, Adrian Muenscher, Rainald Knecht, Guido Sauter, Christoph Moebius, Marco Blessmann, Max Heiland, Christina Pflug
BACKGROUND: βIII-tubulin (TUBB3) is an isotype of microtubules, which are involved in crucial cellular roles including maintenance of cell shape, intracellular transport, and mitosis. Overexpression of TUBB3 was found to be associated with poor prognosis and resistance to tubulin-binding drugs and in several solid tumors including head and neck squamous cell carcinomas (HNSCC). Considering the potential high importance of a prognostic biomarker in these cancers, the present study aimed to investigate the clinical relevance of immunohistochemical TUBB3 expression in HNSCC...
June 22, 2017: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/28640935/additive-effect-of-radiosensitization-by-2-deoxy-d-glucose-delays-dna-repair-kinetics-and-suppresses-cell-proliferation-in-oral-squamous-cell-carcinoma
#2
Mayumi Kawata, Kazuhiro Ogi, Koyo Nishiyama, Sho Miyamoto, Takafumi Nakagaki, Makoto Shimanishi, Akihiro Miyazaki, Hiroyoshi Hiratsuka
BACKGROUND: It has well known that, compared to normal cells, tumor cells have a different manner of energy metabolism, which influences the sensitivity of radiotherapy (RT). However, whether inhibition of glycolysis enhances the efficacy of radiotherapy is a matter of debate in oral squamous cell carcinoma (OSCC). The aim of this study was to characterize whether the combination of radiotherapy with the glucose inhibitor 2-deoxy-D-glucose (2-DG) affected DNA repair kinetics. METHODS: To compare the synergistic effect of 2-DG, we examined the cell survival after treatment with radiation, 2-DG and a combination of the two in 5 OSCC cell lines and one lip fibroblast cell line, determined using clonogenic survival assay...
June 22, 2017: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/28632936/peritumoral-cuffing-by-t-cell-tumor-infiltrating-lymphocytes-distinguishes-hpv-related-oropharyngeal-squamous-cell-carcinoma-from-oral-cavity-squamous-cell-carcinoma
#3
Kate Poropatich, David Hernandez, Joel Fontanarosa, Koshonna Brown, Gayle Woloschak, Ajit Paintal, Kirtee Raparia, Sandeep Samant
BACKGROUND: It is unclear why human papillomavirus (HPV)-related head and neck squamous cell carcinoma (HNSCC) has improved clinical behavior compared to HPV-negative HNSCC. We sought to better characterize the immune microenvironment of tongue cancers by examining the CD3 and CD8 TIL pattern in HPV-positive and -negative tumors. METHODS: Histologic sections from 40 oral tongue and oropharyngeal cases were analyzed (n= 21 HPV DNA-positive, n= 19 HPV DNA-negative)...
June 20, 2017: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/28626969/different-patterns-of-expression-of-cell-cycle-control-and-local-invasion-related-proteins-in-oral-squamous-cell-carcinoma-affecting-young-patients
#4
Marisol Miranda Galvis, Alan Roger Santos-Silva, Juscelino Freitas Jardim, Felipe Paiva Fonseca, Marcio A Lopes, Oslei P Almeida, Clóvis A Lópes Pinto, Estela Kaminagakura, Iris Sawazaki-Calone, Paul M Speight, Luiz Paulo Kowalski
Oral squamous cell carcinoma (OSCC) predominantly affects males in the fifth decade of life; nevertheless, an increased incidence in young patients has been reported worldwide and the clinical and behavioral characteristics of tumors in this group are controversial and the literature shows divergent results PURPOSE: To investigate the clinicopathological features and prognostic significance of the immunoexpression of cell cycle and local invasion proteins in OSCC affecting young patients (≤ 40 years old) METHODS: A tissue microarray was performed with 132 OSCC samples (61 cases of young patients vs...
June 19, 2017: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/28622422/patient-reported-outcome-measures-in-oral-lichen-planus-a-comprehensive-review-of-the-literature-with-focus-on-psychometric-properties-and-interpretability
#5
REVIEW
P Wiriyakijja, S Fedele, S Porter, V Mercadante, R Ni Riordain
OBJECTIVE: To review the range of patient reported outcome measures (PROMs) used in clinical studies of patients with oral lichen planus (OLP) and to assess their psychometric properties and interpretability. METHODS: Literature searches were performed on MEDLINE, Embase and Web of Science databases (1990 - September 2016) to retrieve relevant studies related to the development, psychometric testing and/or use of PROMs assessing oral symptoms, psychosocial status, and quality of life in individuals with OLP...
June 16, 2017: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/28612463/meta-analysis-of-the-predictive-value-of-dna-aneuploidy-in-malignant-transformation-of-oral-potentially-malignant-disorders
#6
REVIEW
N A Alaizari, M Sperandio, E W Odell, D Peruzzo, S A Al-Maweri
DNA aneuploidy is an imbalance of chromosomal DNA content that has been highlighted as a predictor of biological behavior and risk of malignant transformation. To date, DNA aneuploidy in oral potentially malignant diseases (OPMD) has been shown to correlate strongly with severe dysplasia and high-risk lesions that appeared non-dysplastic can be identified by ploidy analysis. Nevertheless, the prognostic value of DNA aneuploidy in predicting malignant transformation of OPMD remains to be validated. The aim of this meta-analysis was to assess the role of DNA aneuploidy in predicting malignant transformation in OPMD...
June 14, 2017: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/28600896/squamous-cell-carcinoma-antigen-as-a-prognostic-marker-and-its-correlation-with-clinicopathological-features-in-head-and-neck-squamous-cell-carcinoma-systematic-review-and-meta-analysis
#7
REVIEW
Daphine Caxias Travassos, Darcy Fernandes, Elaine Maria Sgavioli Massucato, Cláudia Maria Navarro, Andreia Bufalino
BACKGROUND: Several studies investigate the prognostic value of squamous cell carcinoma antigen (SCC-Ag) in head and neck squamous cell carcinoma (HNSCC) patients, with contradicting findings. Considering this, the aim of this study was to evaluate the prognostic value of high SCC-Ag levels and its association with clinicopathological features of HNSCC. MATERIAL AND METHODS: PubMed, SCOPUS, and Cochrane Library were searched for relevant studies up to December 2015...
June 10, 2017: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/28597931/an-in-vitro-study-of-the-long-non-coding-rna-tug1-in-tongue-squamous-cell-carcinoma
#8
Zhi-Qiang Li, Rui Zou, Ke-Xiong Ouyang, Wei-Jian Ai
BACKGROUND: This study sought to study the expression of the long non-coding RNA (lncRNA)taurine-upregulated gene 1 (TUG1) in tongue squamous cell carcinoma (TSCC) and reveal its possible function. METHODS: qRT-PCR was used to evaluate 27 samples of fresh TSCC tissues and adjacent normal tongue tissues. siRNA technology was employed to down-regulate TUG1 expression in CAL-27 and SCC-9 cell lines.The3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetrazolium bromide (MTT) assay was utilized to assess cell proliferation ability; apoptosis and cell cycle phases were analysed via flow cytometry...
June 9, 2017: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/28597929/next-generation-sequencing-of-oncogenes-and-tumor-suppressor-genes-in-odontogenic-myxomas
#9
Jean Nunes Dos Santos, Ernesto Santos Sousa Neto, Josiane Alves França, Marina Gonçalves Diniz, Rennan Garcias Moreira, Wagner Henriques Castro, Ricardo Santiago Gomez, Silvia Ferreira de Sousa, Carolina Cavalieri Gomes
BACKGROUND: Mutations previously considered drivers of malignant neoplasms also occur in benign tumors. From the biological perspective, the study of malignant and benign neoplasms is equally relevant. The study of rare tumors contributes to the understanding of the more common ones, as both could share the same hallmark genetic drivers. The identification of driver mutations in benign tumors is facilitated by the fact that they harbor quiet genomes. Pathogenic mutations have being described in benign epithelial odontogenic tumors, such as ameloblastomas and adenomatoid odontogenic tumors...
June 8, 2017: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/28585308/immunosurveillance-profile-of-oral-squamous-cell-carcinoma-and-oral-epithelial-dysplasia-through-dendritic-and-t-cells-analysis
#10
Ana Carolina Amorim Pellicioli, Lynne Bingle, Paula Farthing, Márcio Ajudarte Lopes, Manoela Domingues Martins, Pablo Agustin Vargas
Oral squamous cell carcinomas (OSCC) can arise from potentially malignant disorders, such as leukoplakia. The immune system plays an important role recognizing tumour precursor cells. However, due to immunoediting mechanisms cancer cells are able to escape immune system surveillance. OBJECTIVE: Evaluate the profile of dendritic (Langerhans and plasmacytoid) and T cells in OSCC and oral epithelial dysplasia (OED) and correlate these findings with clinical data. MATERIALS AND METHODS: Fifty cases of OSCC and 48 of OED were immunostained for CD1a and CD83 dendritic Langerhans cells (DLC), plasmacytoid dendritic cells (pDC) CD303 and CD8 followed by quantitative analysis...
June 5, 2017: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/28556960/the-cellular-character-of-liquefaction-degeneration-in-oral-lichen-planus-and-the-role-of-interferon-gamma
#11
Yuan Liu, Guicai Liu, Qing Liu, Jun Tan, Xin Hu, Jinjin Wang, Qintao Wang, Xinwen Wang
BACKGROUND: Oral lichen planus (OLP) is a T-cell-mediated chronic inflammatory oral mucosal disease of unknown etiology, liquefaction degeneration in the basal keratinocytes is one of the specific histological changes. However, the understanding of liquefaction degeneration is still very limited, and how does it affect the prognosis of LP is largely unknown. Therefore, the objective of this study is to clarify the intrinsic change behind the liquefaction degeneration in lichen planus, and evaluate the effect of the OLP typical cytokines IFN-γon these changes...
May 29, 2017: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/28543912/association-study-of-interleukin-1-family-interleukin-6-and-its-receptor-gene-polymorphisms-in-patients-with-recurrent-aphthous-stomatitis
#12
Lydie Izakovicova Holla, Simona Valova, Petra Borilova Linhartova, Jirina Bartova, Jitka Petanova, Pavel Kuklinek, Antonin Fassmann
BACKGROUND: Recurrent aphthous stomatitis (RAS) is one of the most common oral chronic ulcerative disease in which proinflammatory cytokines such as interleukin-1 (IL-1) and interleukin-6 (IL-6) are thought to play an important role. The aim of this study was to investigate the possible association between polymorphisms in the IL-1 cytokine family, IL-6 or its receptor and RAS in the Czech population. METHODS: A total of 248 subjects, 184 healthy controls, and 64 patients with RAS were genotyped for IL-1A-889C>T, IL-1B-511C>T, IL-1B+3953C>T, IL-1RN86 bp variable number of tandem repeats (VNTRs) in intron 2, IL-6-597G>A, IL-6-572G>C, IL-6-174G>C, and IL-6R+48992A>C by polymerase chain reaction (PCR) methods...
May 20, 2017: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/28520088/clathrin-mediated-endocytosis-is-required-for-ane-30-100k-induced-autophagy
#13
Mei-Huei Lin, Young-Chau Liu, Shyun-Yeu Liu, Fang-Chi Chen, Pei-Jung Yang, Guan-Hua Li, Pang-Yen Liu, Ching-Yu Yen
BACKGROUND: We identified an autophagy-inducing areca nut (AN) ingredient (AIAI) in the 30-100 kDa fraction of AN extract (ANE 30-100K). This study was to analyze the role of endocytosis in ANE 30-100K-induced autophagy. METHODS: We used benzyl alcohol, dynasore, and shRNA of clathrin and dynamin to assess whether ANE 30-100K-induced cytotoxicity and accumulation of microtubule-associated protein 1 light chain 3 (LC3)-II were affected in oral (OECM-1) and esophageal (CE81T/VGH) carcinoma cells...
May 18, 2017: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/28512746/a-panel-of-micrornas-can-be-used-to-determine-oral-squamous-cell-carcinoma
#14
Gareema Prasad, Christine Seers, Eric Reynolds, Michael J McCullough
BACKGROUND: Subjective histopathology is currently used to diagnose oral squamous cell carcinoma (OSCC). We tested if abundances of a panel of microRNA could be an objective OSCC indicator. METHOD: Literature review enabled identification of 10 microRNAs associated with oral and head and neck malignancies. We extracted RNA from formalin-fixed paraffin embedded biopsies; 20 each with OSCC, dysplasia or histologically normal epithelium (HNE) and 10 with oral lichen planus (OLP)...
May 17, 2017: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/28494124/professor-crispian-scully-cbe-dsc-dchd-dmed-hc-dhc-multi-md-phd-phd-hc-fmedsci-mds-mrcs-bsc-fdsrcs-fdsrcps-ffdrcsi-fdsrcsed-frcpath-fhea-1945-2017
#15
Marco Carrozzo
No abstract text is available yet for this article.
May 11, 2017: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/28489259/molecular-alterations-in-odontogenic-keratocysts-as-potential-therapeutic-targets
#16
REVIEW
Carolina Cavalieri Gomes, Letícia Martins Guimarães, Marina Gonçalves Diniz, Ricardo Santiago Gomez
The odontogenic keratocyst (OKC) is a cystic lesion, lined by uniformly-thickened parakeratinized epithelium. Some lesions are large and tend to recur after surgical treatment. The neoplastic nature of OKCs remains a matter of dispute. It is known that some sporadic OKCs harbor PTCH1 mutations, and via the dissection of cyst epithelium, these mutations were demonstrated to occur much more frequently than previously thought. In addition to the classical PTCH1 mutations, Hedgehog pathway disturbance and Bcl-2 protein overexpression, as detected via genome-wide expression analysis of OKCs, have been published...
May 10, 2017: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/28477349/cytological-and-cytomorphometric-evaluation-of-the-oral-mucosa-in-hiv-infected-patients-undergoing-antiretroviral-therapy
#17
Mônica Ghislaine Oliveira Alves, Celina Faig Lima Carta, Adriana Aigotti Haberbeck Brandão, Juvencio José Duailibe Furtado, Marcelo Marcucci, Janete Dias Almeida
BACKGROUND: To evaluate HIV infection-induced alterations in the oral mucosa by comparing inflammation, cell maturation and cytomorphometric changes in oral mucosal cells between HIV-infected patients undergoing highly active antiretroviral therapy (HAART) and non-HIV-infected patients. \ METHODS: Thirty HIV-infected patients undergoing HAART and 30 non-HIV-infected patients were studied. Four smears were obtained from the lateral border of the tongue and floor of the mouth with a cytobrush...
May 6, 2017: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/28477348/the-potential-role-of-in-vivo-optical-coherence-tomography-for-evaluating-oral-soft-tissue-a-systematic-review
#18
REVIEW
Enrica Gentile, Claudio Maio, Antonio Romano, Luigi Laino, Alberta Lucchese
BACKGROUND: The introduction of optical coherence tomography (OCT) in dentistry enabled the integration of already existing clinical and laboratory investigations in the study of the oral cavity. This systematic review presents an overview of the literature, to evaluate the usefulness of in vivo OCT for diagnosing oral soft tissues lesions, to compare the OCT results with traditional histology, and to identify limitations in prior studies so as to improve OCT applications. METHODS: We performed a review of the literature using different search engines (PubMed, ISI Web of Science, and the Cochrane Library) employing MeSH terms such as "optical coherence tomography" and "OCT" in conjunction with other terms...
May 6, 2017: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/28463405/studying-the-association-between-methylenetetrahydrofolate-reductase-mthfr-677-gene-polymorphism-cardiovascular-risk-and-lichen-planus
#19
Laila Rashed, Rania Abdel Hay, Marwa AlKaffas, Shereen Ali, Dina Kadry, Sara Abdallah
BACKGROUND: There is a reported relation between hyperhomocysteinemia and lichen planus (LP). An increase in homocysteine (Hcy) and the risk of cardiovascular disease (CVD) in patients with methylenetetrahydrofolate reductase (MTHFR) mutation has been described. OBJECTIVE: To detect MTHFR (C677T) gene polymorphism, and to find its association with CVD risk, Hcy and folic acid levels in patients with LP. METHODS: This hospital-based case-control study included 110 patients with LP: 70 with cutaneous LP (CLP) and 40 with oral LP (OLP)...
April 30, 2017: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/28437013/the-prognostic-value-of-b7-h6-protein-expression-in-human-oral-squamous-cell-carcinoma
#20
Jiongke Wang, Xin Jin, Jiajia Liu, Kui Zhao, Hao Xu, Jing Wen, Lu Jiang, Xin Zeng, Jing Li, Qianming Chen
OBJECTIVES: To investigate the expression and prognostic value of B7-H6 protein in oral squamous cell carcinoma tissues. MATERIALS AND METHODS: A total of 50 oral squamous cell carcinoma samples, 10 oral leukoplakia samples and 17 normal controls were included in the analysis. The expression of B7-H6 in oral squamous cell carcinoma, oral leukoplakia and normal controls was evaluated by immunohistochemical assay. RESULTS: The B7-H6 protein expression was significantly higher in oral squamous cell carcinoma tissues than that in normal oral mucosa...
April 24, 2017: Journal of Oral Pathology & Medicine
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