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Journal of Oral Pathology & Medicine

Sadeq Ali Al-Maweri, Sajna Ashraf, Butchibabu Kalakonda, Esam Halboub, Waleed Petro, Nader Ahmed AlAizari
BACKGROUND: The aim of the present study was to systematically review the efficacy of photodynamic therapy (PDT) in the management of symptomatic oral lichen planus (OLP). MATERIALS AND METHODS: PubMed/MEDLINE, Scopus, and ISI Web of knowledge were searched until July 2017, using the following keywords: oral lichen planus, erosive lichen planus, lichen planus, and photodynamic therapy. RESULTS: Five clinical studies were included. The risk of bias was considered high in four studies and moderate in one study...
January 19, 2018: Journal of Oral Pathology & Medicine
Jean-Philippe Foy, Chloé Bertolus, Patrick Goudot, Sophie Deneuve, Ellen Blanc, Christine Lasset, David Pérol, Pierre Saintigny
BACKGROUND: Oral squamous cell carcinoma is a major cause of cancer-associated morbidity and mortality and may develop from oral erythroplakia and leukoplakia (OEL), the most common oral potentially malignant lesions. Our objective was to provide a descriptive overview of the global research activity on OEL over the past decades. METHODS: We performed a systematic bibliometric analysis of articles and reviews on OEL up to December 31st 2016 using the SCOPUS database...
January 18, 2018: Journal of Oral Pathology & Medicine
Luís Silva Monteiro, Márcio Diniz-Freitas, Saman Warnakulasuriya, Tomás Garcia-Caballero, Jerónimo Forteza, Máximo Fraga
BACKGROUND: Oral cancer is a major public health problem worldwide, with a poor survival. Our aim was to evaluate several protein markers in oral squamous cell carcinomas (OSCC) and analyse their prognostic value on patient's survival. METHODS: We analysed the expression of EGFR, p53, p27, p16, cyclin D1, cyclin A2, COX-2, Ki-67, Bcl-2, VEGFR-1, and VEGFR-2, by immunohistochemistry on 67 primary OSCC. Cancer-specific survival (CSS) analysis was evaluated by the Cox regression model...
January 18, 2018: Journal of Oral Pathology & Medicine
Tassaporn Kongkaew, Win Pa Pa Aung, Chayarop Supanchart, Anupong Makeudom, Sarawat Langsa-Ard, Thanapat Sastraruji, Ponlatham Chaiyarit, Suttichai Krisanaprakornkit
BACKGROUND: Two post-translational mechanisms commonly demonstrated in various cancers are protein phosphorylation and glycosylation by O-linked β-N-acetylglucosamine (O-GlcNAc). However, only phosphorylation of the epidermal growth factor receptor (EGFR)/Akt pathway has been reported in oral squamous cell carcinoma (OSCC). Therefore, we aimed to determine both post-translational modifications in OSCC tissues and in oral cancer cells compared to normal tissues and oral keratinocytes and to find correlations of these modifications with histological grading...
January 11, 2018: Journal of Oral Pathology & Medicine
Hala H Hazzaa, Ossama M Gouda, Naglaa M Kamal, Shereen Abdel Moula Ali, Marwa A M ElShiekh, Marwa M Tawfik
BACKGROUND: Although several studies have discussed some of the molecular and cellular changes associated with hereditary gingival fibromatosis (HGF), its pathogenesis is still largely unclear. This study was directed to detect and outline the degree of relationship between the immunophenotyped macrophages (M2) expressing CD163 and TGF-β1 in patients with gingival overgrowth due to HGF. METHODS: Biopsies from 20 patients suffering from HGF and 20 normal control subjects were harvested, histologically and immunohistochemically stained then, analyzed and statistically compared and correlated for CD163 immunoexpression and TGF-β1...
January 11, 2018: Journal of Oral Pathology & Medicine
Junhai Ding, Changxi Yang, Sen Yang
BACKGROUND: Aimed at underlying the molecular regulatory mechanism and overall biological functions of LINC00511 in tongue squamous cell carcinoma (TSCC). METHODS: The expression level of LINC00511 was examined by QRT-PCR. In particular, Tca-8113 cell line was selected for subsequent experiments, in which the expression level of LINC00511 was the most significant. Meanwhile, the effects of LINC00511 on cells proliferation, cell cycle distribution and invasion of TSCC cells were explored using RNA knockdown tools with CCK-8, flow cytometry analysis, colony formation and transwell assay...
January 9, 2018: Journal of Oral Pathology & Medicine
Kavan Shah, Shanaya Patel, Bansri Modi, Franky Shah, Rakesh Rawal
OBJECTIVES: Late stage diagnosis is one of the major confounders for poor prognosis of oral cancer patients owing to lack of a biomarker to diagnose this disease at an early stage. Moreover, till date invasive biopsies are the only option to assess disease occurrence and progression in this malignancy. Thus, this study aims to identify and assess potential salivary markers in OSCC patients in order to open newer avenues in the field of non-invasive biopsies. METHODOLOGY: Bioinformatic based analysis were performed to identify potential biomarkers that could be assessed in OSCC patients...
January 8, 2018: Journal of Oral Pathology & Medicine
Flávia Sirotheau Corrêa Pontes, Hélder Antônio Rebelo Pontes, Lucas Lacerda de Souza, Adriana Souza de Jesus, Andrea Maia Correa Joaquim, Ligia Akiko Ninokata Miyahara, Felipe Paiva Fonseca, Décio Dos Santos Pinto Júnior
OBJECTIVES: The aim of this study was to evaluate the expression of Akt, PTEN, Mdm2 and p53 proteins in three different head and neck squamous cell carcinoma (HNSCC) cell lines (HN6, HN19 and HN30), all of them treated with epidermal growth factor (EGF) and 17-allylamino-17-demethoxygeldanamycin (17-AAG), an inhibitor of Hsp90 protein. MATERIAL AND METHODS: Immunofluorescence and western blot were performed in order to analyze the location and quantification, respectively, of proteins under the action 17-AAG and EGF...
January 3, 2018: Journal of Oral Pathology & Medicine
Camile S Farah, Kate Amos, Rachel Leeson, Stephen Porter
OBJECTIVES: Oral dysesthesia (burning mouth syndrome) is characterised by a burning-like sensation of the oral mucosa. The aetiology of this disorder is still unknown, however associations with oral fungal carriage have been proposed and applied clinically. The aim of the this study was to compare oral Candida carriage in patients with oral dysesthesia with Candida carriage in patients with other commonly diagnosed oral diseases to clarify the relationship between Candida and oral dysesthesia...
January 2, 2018: Journal of Oral Pathology & Medicine
Anacláudia Pereira Costa Flores, Kelly Bienk Dias, Laura de Campos Hildebrand, Márcia Gaiger de Oliveira, Marcelo Lazzaron Lamers, Manoel Sant'Ana Filho
BACKGROUND: Focal adhesion kinase (FAK) phosphorylation contributes to the regulation of growth factors that promote cellular adhesion, mobility, and survival, being a key factor in tumor development. The objective of this study was to evaluate the immunohistochemical expression patterns of FAK and its phosphorylated forms, FAK Tyr-576 and FAK Tyr-925, in head and neck squamous cell carcinoma and non-neoplastic adjacent epithelial tissue. METHODS: The percentage of immunohistochemistry stained cells and its correlation with clinicopathological variables and prognosis were determined using samples from 54 patients...
January 2, 2018: Journal of Oral Pathology & Medicine
Julie C Nienstedt, Cornelia Schroeder, Till Clauditz, Ronald Simon, Guido Sauter, Adrian Muenscher, Marco Blessmann, Henning Hanken, Christina Pflug
BACKGROUND: Enhancer of zeste homolog 2 (EZH2), the catalytic subunit of the polycomb repressive complex 2, plays an important role in tumor development and progression by interacting with histone and non-histone proteins. EZH2 represents a putative therapeutic target and has been suggested as a prognostic marker in several cancer types. MATERIAL AND METHODS: The present study investigates the prognostic relevance of immunohistochemical EZH2 expression in head and neck squamous cell carcinoma...
December 29, 2017: Journal of Oral Pathology & Medicine
Yingci Liu, Richard J Vargo, Elizabeth A Bilodeau
BACKGROUND: Oral lesions have been reported among the first signs of an undiagnosed metastatic disease. Accurate diagnosis of an occult metastasis remains critical in determining the treatment course. Previous studies regarding oral metastatic tumors present varied data regarding the most frequent metastases to the oral cavity. These discrepancies echo the changes in incidence rates for certain malignancies over time and demonstrate the need for periodic updates in oral metastasis studies...
December 28, 2017: Journal of Oral Pathology & Medicine
Josiane Alves França, Sílvia Ferreira de Sousa, Marina Gonçalves Diniz, Thaís Dos Santos Fontes Pereira, Taynara Asevedo Campos de Resende, Jean Nunes Dos Santos, Ricardo Santiago Gomez, Carolina Cavalieri Gomes
BACKGROUND: Mutations in the patched 1 (PTCH1) gene are the main genetic alteration reported in sporadic and nevoid basal cell carcinoma associated-odontogenic keratocyst (OKC). Oncogenic mutations, including BRAFV600E, previously considered exclusive of malignant neoplasms have been reported in odontogenic tumors. Recently, a high frequency of BRAFV600E mutation has been reported in OKC. Because of the considerable recurrence rate of OKC, the identification of druggable genetic mutations can be relevant in the management of extensive lesions...
December 22, 2017: Journal of Oral Pathology & Medicine
E Schiegnitz, P W Kämmerer, H Schön, S Blatt, M Berres, K Sagheb, B Al-Nawas
BACKGROUND: Inflammation and cell-mediated immunity have a key role in different stages of carcinogenesis. The aim of this prospective study was to assess serum levels of proinflammatory cytokines interleukin-6 (IL-6), interleukin-8 (IL-8), soluble interleukin-2 receptor (sIL-2R), tumour necrosis factor alpha (TNF-α) and MHC class I polypeptide-related sequence B (MICB) in patients with oral premalignant lesion (OPL), oral squamous cell carcinoma (OSCC) and healthy controls in a multi-biomarker approach as a potential diagnostic and prognostic tool for OSCC...
December 22, 2017: Journal of Oral Pathology & Medicine
Bruna Larissa Lago Silva, Danila Lima Medeiros, Ana Prates Soares, Sérgio Roberto Peres Line, Maria das Graças Farias Pinto, Telma de Jesus Soares, Alexandre Ribeiro do Espírito Santo
BACKGROUND: Type 1 diabetes mellitus (T1DM) largely affects children, occurring therefore at the same period of deciduous and permanent teeth development. The aim of the present work was to investigate birefringence and morphology of the secretory stage enamel organic extracellular matrix (EOECM), and structural and mechanical features of mature enamel from T1DM rats. METHODS: Adult Wistar rats were maintained alive for a period of 56 days after the induction of experimental T1DM with a single dose of streptozotocin (60 mg/kg)...
December 14, 2017: Journal of Oral Pathology & Medicine
Cheng-Chia Yu, Yi-Wen Liao, Chuan-Hang Yu, Yu-Chao Chang
BACKGROUND: STRO-1 is a mesenchymal cell marker present on all clonogenic stromal precursors. Current evidence has indicated that the pathogenesis of fibrotic changes may be mediated by stemness properties. The aim of this study was to investigate the role of STRO-1 in areca quid chewing-associated oral submucous fibrosis (OSF). METHODS: Thirty OSF specimens and ten normal buccal mucosa were examined by immunohistochemistry. The activity of STRO-1 from fibroblasts cultured from normal buccal mucosa (BMFs) and OSF (OSFFs) were measureed and the effects of arecoline, a major areca nut alkaloid, on STRO-1 in BMFs...
December 6, 2017: Journal of Oral Pathology & Medicine
Alison Barry, Ken D O'Halloran, Joseph P McKenna, Christine McCreary, Eric J Downer
BACKGROUND: Burning mouth syndrome (BMS) is a neuropathic orofacial pain condition of unknown aetiology that encompasses intra-oral burning pain without abnormal clinical findings. Psychological, neural and inflammatory processes are associated with BMS pathogenesis. Currently, studies characterising plasma cytokine/chemokine profiles with pain and depression in BMS patients are lacking. Considering that inflammation is associated with the pathophysiology of BMS, and that inflammation is closely associated with pain and depression, we aimed to correlate depressive symptomatology and oral cavity pain with plasma cytokine/chemokine signatures in a cohort of patients with BMS...
December 1, 2017: Journal of Oral Pathology & Medicine
Gargi S Sarode, Sachin C Sarode, Nikunj Maniyar, Rahul Anand, Shankargouda Patil
Cancer database is a systemic collection and analysis of information on various human cancers at genomic and molecular level that can be utilized to understand various steps in carcinogenesis and for therapeutic advancement in cancer field. Oral cancer is one of the leading causes of morbidity and mortality all over the world. The current research efforts in this field are aimed at cancer etiology and therapy. Advanced genomic technologies including microarrays, proteomics, transcrpitomics and gene sequencing development have culminated in generation of extensive data and subjection of several genes and microRNAs that are distinctively expressed and this information is stored in the form of various databases...
November 29, 2017: Journal of Oral Pathology & Medicine
A Al-Hassiny, L T Friedlander, V Pb Parachuru, B Seo, H M Hussaini, A M Rich
OBJECTIVES: Since angiogenesis is fundamental to the pathogenesis of many chronic inflammatory disorders this study investigated the expression of various vascular markers in oral lichen planus and non-specific oral mucosal inflammatory tissues. METHODS: Archival specimens of oral lichen planus (n=15) and inflamed tissues (n=13) were stained using immunohistochemistry with antibodies to CD34, vascular endothelial growth factor, vascular endothelial growth factor receptor and vasohibin...
November 24, 2017: Journal of Oral Pathology & Medicine
Abeer Shaalan, Guy Carpenter, Gordon Proctor
BACKGROUND: Salivary gland (SG) injurious agents are all translated into loss of salivation (xerostomia). An association has been established between activation of innate immunity and salivary gland injury and dysfunction. However, it remains unclear how the secretory epithelia respond by halting saliva production. METHODS: C57BL/6 submandibular glands (SMGs) were acutely challenged using a single dose of the innate immune stimulant: polyinosinic-polycytidylic acid (poly (I:C))...
November 21, 2017: Journal of Oral Pathology & Medicine
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