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Journal of Oral Pathology & Medicine

Mayumi Kamaguchi, Hiroaki Iwata, Toshinari Miyauchi, Hideyuki Ujiie, Inkin Ujiie, Toshifumi Nomura, Noritaka Ohga, Hiroshi Shimizu, Yoshimasa Kitagawa
BACKGROUND: Mucous membrane pemphigoid (MMP) is a rare chronic autoimmune subepithelial blistering disorder, targeting multiple basement membrane zone (BMZ) proteins including collagen XVII (COL17). Circulating autoantibodies of MMP are often undetected due to their lower titers. The oral mucosa is a valuable substrate for the detection of autoantibodies in MMP patients. However, obtaining normal human oral mucosa is more difficult than obtaining normal human skin. We established immortalized normal human oral mucosal keratinocytes (OMKs) and performed immunoblotting using immortalized OMK lysate for detecting autoantigens in MMP...
September 17, 2018: Journal of Oral Pathology & Medicine
X J David Lu, Kelly Y P Liu, Rosilene C Soares, Thomas Thomson, Eitan Prisman, Jonn Wu, Catherine F Poh
BACKGROUND: There is increasing evidence that high-risk human papillomavirus plays significant role in oropharyngeal cancer; however, there is lack of knowledge on the interplay between the virus and its downstream related molecules and their possible prognostic values. The objectives of the study are to better understand the interplay of the HR-HPV and its associated downstream molecules and to evaluate potential biomarkers for patient outcomes. METHODS: We conducted a retrospective study with available formalin-fixed, paraffin-embedded tissue from 244 oropharyngeal cancer patients that received curative radiotherapy or concurrent chemoradiotherapy from 2000 to 2008...
September 6, 2018: Journal of Oral Pathology & Medicine
Daniela Assis do Vale, Natália Silva Andrade, Jorge Casseb, Augusto Penalva de Oliveira, Ivo Bussolotti Filho, Marilia Trierveiler, Karem López Ortega
BACKGROUND: Among the complex of HTLV-associated diseases, Sjögren's syndrome (SS) is one of the most controversial. This work aims to detect morphological and inflammatory alterations, including clues of the presence of HTLV-1, in minor salivary glands of patients with dryness symptoms. METHODS: We have assessed HTLV-1-seropositive patients (HTLV-1 group) and patients with SS (SS group). We used formalin-fixed, paraffin-embedded minor salivary gland tissue to evaluate the morphological aspects and, by means of immunohistochemistry, the presence of Tax protein, CD4, CD8 and CD20 cells...
September 3, 2018: Journal of Oral Pathology & Medicine
Gwendolyn Huang, Lynette Moore, Richard M Logan, Sumant Gue
BACKGROUND: Dentigerous cysts are usually of developmental nature but may be of inflammatory origin especially in paediatric populations. It is important to understand the histological features of dentigerous cysts to enable accurate diagnosis. The aim of this study is to present epidemiological, clinical features and histopathological features of dentigerous cysts seen in a paediatric tertiary-referral hospital. METHOD: The medical, radiographic and histopathology records of the Department of Pathology, Women's and Children's Hospital, Adelaide, Australia during January 1998 to December 2013 were reviewed for patients with dentigerous cysts...
September 3, 2018: Journal of Oral Pathology & Medicine
Aurigena Antunes de Araújo, Lorena de Souza Araújo, Caroline Addison Carvalho Xavier de Medeiros, Renata Ferreira de Carvalho Leitão, Gerly Anne de Castro Brito, Deiziane Viana da Silva Costa, Gerlane Coelho Bernardo Guerra, Vinicius Barreto Garcia, Maria Laura de Souza Lima, Raimundo Fernandes de Araújo Junior
BACKGROUND: The aim of this study was to evaluate the effect of olmesartan medoxomil (Olme), an angiotensin II receptor antagonist, on oral mucositis (OM) experimental model. METHODS: Oral mucositis was induced in hamsters with 5-fluorouracil (5-FU; 60 mg/kg day 1 and 40 mg/kg day 2). Animals (n = 10/group) were pretreated with oral Olme (1, 5, or 10 mg/kg) or vehicle 30 minutes before 5-FU injection and daily, until day 10. Cheek pouch samples were subjected to histopathological and immunostaining analysis of IL-1β, TNF-α, IL-10, TGF-β, macrophage migration inhibitory factor (MIF), SOD, MMP-2 and FGF-2...
August 20, 2018: Journal of Oral Pathology & Medicine
Houyu Ju, Lu Mao, Liming Zhang, Shuli Liu, Yunteng Wu, Min Ruan, Jingzhou Hu, Guoxin Ren
BACKGROUND: Hyperthermia is currently used as an alternative to surgery or in combination with chemotherapy and/or radiation therapy in the treatment of oral squamous cell carcinoma. However, little has been known about the change in chemo-sensitivity after hyperthermia and the mechanism underlie it in oral squamous cell carcinoma. METHODS: The aim of this study was to explore the influence of chemo-sensitivity of CAL-27 and SCC-4 cells by histoculture drug response assay after the animal model treated by the ultrasound hyperthermia...
August 16, 2018: Journal of Oral Pathology & Medicine
Bruno A L A Mariz, Ciro D Soares, Thayná M L Morais, Felipe P Fonseca, Maria G F de Carvalho, Jacks Jorge
Fibroblast growth factor 2 (FGF-2) is a multifunctional cytokine expressed in several tissues and involved in a wide variety of biologic activities, with one low molecular weight (LMW) protein present in the cytosol, which is secreted, acting via its receptors (FGFRs), and four high molecular weight (HMW) proteins located in the nucleus. Fibroblast growth factor receptor (FGFR) family has four (FGFR1-4) transmembrane tyrosine kinase receptors expressed on several cell types, and FGFR-1 has been indicated as a potential molecular target in several types of cancer, including oral squamous cell carcinoma (OSCC)...
August 6, 2018: Journal of Oral Pathology & Medicine
Dominik Gurin, Marek Slavik, Marketa Hermanova, Tetiana Shatokhina, Jiri Sana, Tomas Kazda, Iveta Selingerova, Parwez Ahmad, Pavel Smilek, Zuzana Horakova, Michal Hendrych, Pavel Slampa, Ondrej Slaby
OBJECTIVES: To examine combined immunoprofiles of epidermal growth factor receptor (EGFR), CD44, and p16 in oropharyngeal squamous cell carcinoma (OPSCC) and to correlate them with radiotherapy treatment outcomes and clinicopathological parameters. Prognostic impact of the American Joint Committee on Cancer (AJCC) 8th edition staging system in comparison with 7th edition was analyzed. METHODS: The study included 77 OPSCC patients treated by definitive intensity-modulated radiotherapy (IMRT)...
August 6, 2018: Journal of Oral Pathology & Medicine
Lorena Salazar-García, Mario Pérez-Sayáns, Abel García-García, Ángel Carracedo, Raquel Cruz, Antonio Lozano, Beatriz Sobrino, Francisco Barros
BACKGROUND: Head and neck squamous cell carcinoma (HNSCC) is a global public health problem, which increases in prevalence every year. Evidence brings up that small populations of stem cells, the cancer stem cells (CSC), are responsible for tumour initiation, tumorigenesis, progression, and metastasis. These cells play a crucial role in cancer development and treatment response, but the origin of CSCs remains unclear. In this research, we have sequenced the entire exome of the three different groups of cells of primary squamous cell carcinoma tumour from different patients, with the aim to understand their main genetic changes and to elucidate the possible origin of tumour cells and tumour stem cells...
August 1, 2018: Journal of Oral Pathology & Medicine
Smitha Thammaiah, Mohan C Venkobarao, Hemavathy Sathyavanthan, Angeline S Mirnalini
BACKGROUND: Although human papillomavirus (HPV) is considered as a causative factor in oral squamous cell carcinoma (OSCCs), its pathogenetic role is not well established. Moreover, a limited number of studies have compared the techniques of detecting the HPV infection in OSCC. This study aimed at the detection of HPV 16 E6 and E7 DNA in OSCC by quantitative polymerase chain reaction (qPCR) technique. METHODOLOGY: This retrospective study included 297 tissue sections obtained from histopathologically confirmed OSCC patients...
July 30, 2018: Journal of Oral Pathology & Medicine
Xia Wang, Wei Liu, Peiyuan Wang, Shu Li
BACKGROUND: Long noncoding RNA HOX transcript antisense RNA (lncRNA HOTAIR) is overexpressed in many types of human cancers and is correlated with clinical stage and lymph node metastasis in oral squamous cell carcinoma (OSCC). Autophagy, an important mechanism of self-protection, plays vital roles in adapting to hypoxia, tolerating external stimulation, and inducing chemotherapy resistance in OSCC cells. This study aims to investigate the effect of HOTAIR on autophagy, apoptosis, and invasion of OSCC cells...
July 27, 2018: Journal of Oral Pathology & Medicine
Mei-Yin Ye, Meng-Yen Chen, Ya-Han Chang, Jehn-Shyun Huang, Tze-Ta Huang, Tung-Yiu Wong, Tse-Ming Hong, Yuh-Ling Chen
BACKGROUND: Oral squamous cell carcinoma (OSCC) is a common human malignancy and is usually preceded by the oral precancerous lesions. Oral submucous fibrosis (OSF) is one of the oral precancerous lesions with high incidence of malignant transformation. In addition to cancer cells, cancer-associated fibroblasts in the tumor microenvironment are correlated with cancer progression, but the role of fibroblasts from OSF in tumorigenesis and progression is still unknown. Growth-regulated oncogene-α (GRO-α), a member of CXC chemokine family, is related to tumorigenesis in several cancers...
July 23, 2018: Journal of Oral Pathology & Medicine
Jun Zheng, Lichun Sun, Wumei Yuan, Jiang Xu, Xinle Yu, Fazhan Wang, Lisha Sun, Yan Zeng
BACKGROUND: N-α-acetyltransferase 10 protein (Naa10p) is a potential prognostic biomarker that modulates the phenotypes of several cancer types. Carcinoembryonic antigen (CEA) is currently the most well-known biomarker for the detection of epithelial malignancies. Our objective was to evaluate the clinical value of Naa10p, CEA, and their combined detection for diagnosis of oral squamous cell carcinoma (OSCC). METHODS: This study included 202 individuals: 112 patients with OSCC, 30 patients with oral premalignant lesions (OPMLs), and 60 cancer-free and without OPML patients as control...
July 20, 2018: Journal of Oral Pathology & Medicine
Mara Luana Batista Severo, Maria Luiza Diniz de Sousa Lopes, Márcia Cristina da Costa Miguel, Adriano Rocha Germano, Renato Luiz Maia Nogueira, Eveline Turatti, Roberta Barroso Cavalcante, Éricka Janine Dantas da Silveira
BACKGROUND: This study analyzed the immunoexpression of calcitonin receptor (CTR) and glucocorticoid receptor (GR) in central giant cell lesions (CGCLs) and verified potential associations with patient's response to clinical treatment with intralesional injection of triamcinolone. MATERIALS AND METHODS: Fifty-four cases of CGCLs, including 22 non-aggressive, and 32 aggressive, were investigated by immunohistochemistry. RESULTS: Surgery was the therapeutic choice for 53...
July 20, 2018: Journal of Oral Pathology & Medicine
Lili Wei, Haofei Xiong, Wei Li, Bo Li, Yong Cheng
BACKGROUND: The human salivary gland (HSG) cell line has so far been used as in vitro models for study of the influence of cytokines and pharmacologic agents on salivary glands, as well as a model system for inflammation in Sjögren's syndrome (SS). This study aimed to determine the effect of IL-17 on IL-6 production and the underlying molecular mechanism regulated by the HSG cell line. METHODS: Immunofluorescence analyses, RT-PCR, and Western blot were conducted to evaluate the IL-17 receptor (IL-17R) expression in cultured HSG cells...
July 14, 2018: Journal of Oral Pathology & Medicine
Ahoud A Jazzar, Penelope J Shirlaw, Guy H Carpenter, Stephen J Challacombe, Gordon B Proctor
BACKGROUND: Sjögren's syndrome (SS) is an autoimmune inflammatory disease that affects the exocrine glands. The absence of early diagnostic markers contributes to delays in its diagnosis. Identification of changes in the protein profile of saliva is considered one of the promising strategies for the discovery of new biomarkers for SS. OBJECTIVE: To identify salivary protein biomarkers with potential for use in discriminating between different lymphoma risk subgroups of SS...
July 12, 2018: Journal of Oral Pathology & Medicine
Jian-Lin Liu, An-Qi Zhang, Li-Cheng Jiang, Ke-Yi Li, Feng-Zhen Liu, Dao-Ying Yuan, Kai Xu, Qing-Chun Fan, Xian-Bin Liu, Bo Zou, Zheng Meng, Yuan Feng, Bin Zhang
OBJECTIVES: Mucocele of the minor salivary gland is usually caused when the duct is injured, mucus leaks into the tissue space and the mucous gland are obstructed, which lead to cystic lesion formation and dilatation. Currently, there are multiple therapeutic methods available with various outcomes. This study aims to provide clinical evidence of polidocanol sclerotherapy for the treatment of mucocele of the minor salivary gland. METHODS: In this study, we injected polidocanol into 112 patients who were diagnosed with mucocele of the minor salivary gland and evaluated the treatment efficacy and safety systematically...
July 12, 2018: Journal of Oral Pathology & Medicine
Zinan Yang, Kan Li, Qian Liang, Guangsen Zheng, Sien Zhang, Xiaomei Lao, Yujie Liang, Guiqing Liao
BACKGROUND: The process of marsupialization involves the release of intracystic pressure and the fluid contained within. Marsupialization of cystic ameloblastoma is controversial; therefore, we investigated how hydrostatic pressure influences biological behaviours of ameloblastoma cells and its underlying mechanisms. MATERIALS AND METHODS: An ameloblastoma epithelial cell line, hTERT+ -AM, was exposed to different hydrostatic pressures with or without Dickkopf-related protein 1 (also known as DKK), a canonical Wnt signalling pathway inhibitor...
July 2, 2018: Journal of Oral Pathology & Medicine
Ricardo Natã Fonseca Silva, Laís Bueno Dallarmi, Ana Karoline Carvalho Araujo, Rita Cassia Gonçalves Alencar, Elismauro Francisco Mendonça, Tarcília Aparecida Silva, Aline Carvalho Batista, Nadia Lago Costa
BACKGROUND: Tumor-associated neutrophils (TAN), matrix metalloproteinase-9 (MMP-9), interleukin-17 (IL-17), and angiogenesis have been proposed as prognostic biomarkers of malignant tumors. The purpose of this study was to investigate these inflammatory markers as prognostic factors for oral squamous cell carcinoma (OSCC). METHODS: Specimens of OSCC (n = 30), healthy oral mucosa (negative control, n = 10), oral leukoplakia (n = 10), and apical granuloma with abscess (positive inflammatory controls, n = 10) were immunostained for CD66b (neutrophils), MMP-9, IL-17, and CD105 (neoformed microvessels)...
July 2, 2018: Journal of Oral Pathology & Medicine
Yuxian Song, Qian Zhou, Huidong Zhu, Yue Jing, Xiaoxin Zhang, Yan Yang, Qingang Hu, Xiaofeng Huang, Yanhong Ni
BACKGROUND: Monocytes, which subdivided into three functional subsets (classical, intermediate, and nonclassical), play important roles in the progression of cancer. The subset composition is altered in several pathologic conditions including cancers. However, the composition and function of circulating monocyte subsets in patients with oral squamous cell carcinoma (OSCC) are still obscure. METHODS: The frequencies of monocyte subsets in peripheral blood of patients with OSCC and healthy donors are determined by flow cytometry, and their diagnostic values for OSCC were evaluated...
July 1, 2018: Journal of Oral Pathology & Medicine
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