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Journal of Oral Pathology & Medicine

Hisato Yoshida, Hitomi Hoshino, Yoshiaki Imamura, Hitoshi Yoshimura, Kazuo Sano, Motohiro Kobayashi
BACKGROUND: Tumor-infiltrating lymphocytes (TILs) reportedly play a pivotal role in anti-tumor immunity against oral squamous cell carcinoma (OSCC); however, mechanisms governing TIL recruitment to OSCC tissues remain to be clarified. The present study was undertaken to assess a potential association between TILs and high endothelial venule (HEV)-like vessels that express sialyl 6-sulfo Lewis X (LeX). METHODS: OSCC tissue sections (n = 41) were subjected to immunohistochemistry for sialyl 6-sulfo LeX and CD34 to allow quantitation of HEV-like vessels...
April 20, 2017: Journal of Oral Pathology & Medicine
Klas Strindlund, Giuseppe Troiano, Nicola Sgaramella, Philip J Coates, Xiaolian Gu, Linda Boldrup, Luigi Califano, Robin Fahraeus, Lorenzo Lo Muzio, Fatima Ardito, Giuseppe Colella, Gianpaolo Tartaro, Renato Franco, Lena Norberg-Spaak, Mohammad Saadat, Karin Nylander
BACKGROUND: c-MYC is a potent oncoprotein with roles in a wide range of cellular processes such as differentiation, apoptosis and growth control. Deregulation of the MYC gene is commonly seen in human tumours resulting in overexpression of the protein. Here we studied expression of c-MYC in correlation to clinical outcome in patients with primary squamous cell carcinoma of the mobile tongue. METHODS: Immunohistochemistry was used to identify c-MYC in a group of 104 tongue squamous cell carcinomas with an antibody directed against the N-terminal part of the protein...
April 10, 2017: Journal of Oral Pathology & Medicine
Gururaj Arakeri, Shekar Gowda Patil, Abdulsalam S Aljabab, Kuan-Chou Lin, M A W Merkx, Shan Gao, Peter A Brennan
Oral submucous fibrosis (OSMF) is a potentially malignant condition associated with areca nut chewing. Formerly confined to the Indian subcontinent, it is now often seen in Asian populations of the United Kingdom, USA, and other developed countries, and is therefore a serious problem for global health. What makes it more sinister is the malignant transformation rate, which has been reported to be around 7.6% over a 17-year period. In this concise article, we review the current trends in the pathophysiology of malignant transformation of OSMF...
April 9, 2017: Journal of Oral Pathology & Medicine
Gururaj Arakeri, Kirthi Kumar Rai, Santosh Hunasgi, M A W Merkx, Shan Gao, Peter A Brennan
Over the last 40 years, many theories linking oral submucous fibrosis (OSMF) to various risk factors have been proposed. The common Asian habit of repeatedly chronically exposing the oral mucosa with spicy, pungent foods and irritants like supari (areca nut), paan (betel leaves), tobacco (through chewing or smoking) have all been incriminated as causative agents. Systemic factors like nutritional deficiency, genetic predisposition and autoimmunity have also been proposed in the pathogenesis of OSMF. However the precise aetiology of OSMF is still unknown and no conclusive evidence has been found despite many extensive investigations on implicated factors...
April 9, 2017: Journal of Oral Pathology & Medicine
Gururaj Arakeri, George Boraks, Shekar Gowda Patil, Abdulsalam S Aljabab, M A W Merkx, Marco Carrozzo, Peter A Brennan
Oral Submucous Fibrosis (OSMF) is a debilitating condition of oral cavity which has significant potential for malignant transformation. In spite of over 20 years of research, the pathogenesis of the condition is still obscure and no single management modality is effective. Many OSMF treatment protocols have been proposed to alleviate the signs and symptoms of the disorder and there is overwhelming evidence that since areca nut is primary cause, stopping its use may have a considerable effect on symptoms rather than reversing pre-existing fibrosis...
April 9, 2017: Journal of Oral Pathology & Medicine
Daniela Adamo, Marco Cascone, Antonio Celentano, E Ruoppo, Stefania Leuci, Massimo Aria, Michele D Mignogna
OBJECTIVES: To analyze intra, extra-oral symptoms and psychological profiles in symptomatic patients with reticular (R) forms of oral lichen planus (OLP). MATERIALS AND METHODS: Thirty symptomatic R-OLP (sR-OLP) patients were compared with an equal number of non-symptomatic R-OLP (nsR-OLP) patients, burning mouth syndrome (BMS) patients and healthy subjects (HS). The Numeric Rating Scale (NRS), the Total Pain Rating Index (T-PRI) and the Hamilton Rating Scales for Depression (HAM-D) and Anxiety (HAM-A) were administered...
April 8, 2017: Journal of Oral Pathology & Medicine
Priscila Laiza Rubim Leão, Helvécio Marangon Junior, Victória Vasconcellos Moreira Melo, Ângela Braga Caixeta, Paulo Eduardo Alencar Souza, Maria Cássia Ferreira de Aguiar, Martinho Campolina Rebello Horta
BACKGROUND: This study aimed to analyze the reproducibility, repeatability and level of difficulty of two methods for tumor budding evaluation in oral squamous cell carcinoma (OSCC): staining by hematoxylin and eosin (HE), and immunostaining for multi-cytokeratin. METHODS: The evaluation of tumor budding was performed by three examiners in 103 samples of OSCC, using the two methods. A Likert-type scale was used to measure the difficulty in the assessment. The inter-examiner agreement (reproducibility) was estimated using Fleiss's Kappa and the intra-examiner agreement (repeatability) was estimated using Cohen's Kappa...
April 6, 2017: Journal of Oral Pathology & Medicine
Maryam Jessri, Andrew J Dalley, Camile S Farah
BACKGROUND: Approximately 20% of oral squamous cell carcinoma (OSCC) cases arise without any identifiable environmental cause, suggesting involvement of genetic influences in their aetiology. DNA double strand breaks (DSBs) sever both strands of DNA and pose a potential threat to genomic integrity. A hastened accumulation of somatic mutations consequent to DSB repair is deemed to be a likely event in tumorigenesis of OSCC. METHODS: Two discrete chemical approaches, namely hydrogen peroxide and camptothecin, were used to induce DSB in oral cell lines derived from normal through dysplastic to OSCC tissues...
April 6, 2017: Journal of Oral Pathology & Medicine
Patrícia Carlos Caldeira, Érica Leandro Marciano Vieira, Alexandre Andrade Sousa, Antônio Lúcio Teixeira, Maria Cássia Ferreira de Aguiar
BACKGROUND: The aim was to explore the immunophenotype of neutrophils and lymphocytes and the inflammatory mediators in patients with oral squamous cell carcinoma, comparing with controls; and to associate with clinicopathological data. METHODS: Blood was collected from patients and controls. The immunophenotype of neutrophils (CD66b, CD16, CD11a, arginase-1), T lymphocytes (CD4, CD8) and the intracellular cytokine production (IL-10, TNF, IFN-γ) was evaluated by flow cytometry...
March 29, 2017: Journal of Oral Pathology & Medicine
Antonio Rossi, Leticia Ferreira, Maria Cuevas-Nunez, John M Wright, Alfredo M De-Paula, John R Basile, Bruno C Jham
Kaposi's sarcoma (KS) persists today as a highly prevalent vascular cancer, often found in HIV patients. Studies have shown that angiopoietin 2 (Ang2), a pro-angiogenic protein, is involved in the pathogenesis of this tumor. However, expression of this protein has not been investigated in oral KS lesions. Thus, we aimed to investigate the expression of Ang2 in samples of oral KS METHODS: Immunohistochemistry was used to evaluate Ang2 expression in 14 oral KS cases, with degrees of expression being analyzed in a semi-quantitative manner...
March 29, 2017: Journal of Oral Pathology & Medicine
Hui Shan Ong, Sandhya Gokavarapu, Zhen Tian, Jiang Li, Qin Xu, Cao Wei, Chen Ping Zhang
BACKGROUND: Platelet derived growth factors alpha (PDGFA) is a tyrosine kinase receptor activator which known to be amplified in the malignancies and their expression levels are correlated to tumor progression and reduced overall survival. The expression of PDGFRA is different among the tumors and normal tissues, furthermore; their expression level is site-specific. Under a physiological condition, PDGFRA and its ligand are expressed in distinct cell populations and activated in a paracrine manner...
March 25, 2017: Journal of Oral Pathology & Medicine
Xiaohui Li, Bo Yang, Guoxu Han, Weizhong Li
BACKGROUND: Recent studies suggest that cyclooxygenase 2 (COX-2) inhibitors may enhance the toxic effects of anticancer drugs on tumor cells, including oral squamous cell carcinoma (OSCC), but its long-term use can cause side effects such as stomach ulcers and myocardial infarction. Our aim was to investigate proliferative effects of a downstream product of COX-2, prostaglandin E2 (PGE2), in human oral squamous carcinoma cell line Tca8113 and explore the effects of PGE2 receptors, especially EP4 receptor, on the growth of Tca8113 cells...
March 25, 2017: Journal of Oral Pathology & Medicine
Ben Tudor-Green, Felipe Paiva Fonseca, Ricardo Gomez, Peter A Brennan
Head and neck hard tissue sarcomas form a rare group of mesenchymal derived tumours that comprise less than 1% of all head and neck neoplasms. Hard tissue sarcomas account for 20% of head and neck sarcomas and they form a heterogeneous group with a diverse origin. Unlike head and neck soft tissue sarcomas, they have lower recurrence and mortality rates. In this article, we review the current management of head and neck hard tissue sarcomas. This article is protected by copyright. All rights reserved.
March 24, 2017: Journal of Oral Pathology & Medicine
Po-Yu Yang, Yi-Tzu Chen, Yu-Hsun Wang, Ni-Yu Su, Hui-Chieh Yu, Yu-Chao Chang
BACKGROUND: Oral submucous fibrosis (OSF) is a one of the well-recognized oral potentially malignant disorders. In this study, we investigated the malignant transformation of OSF in a Taiwanese population. METHODS: A retrospective cohort study was analyzed from Taiwan's National Health Insurance Research Database. A comparison cohort that was randomly frequency-matched with the OSF cohort according to age, sex, and index year. Oral leukoplakia (OL) was further stratified to evaluate for the possible synergistic effects for OSF-associated malignant transformation...
March 14, 2017: Journal of Oral Pathology & Medicine
Nikita Gulati, Devi Charan Shetty, Ajit Singh Rathore, Saurabh Juneja, Anshi Jain
BACKGROUND: Bcl-2 and E-cadherin proteins are known to be involved in the control of apoptotic cell death and invasive potential, respectively, which is an important hallmark of tumor regulation that influences their biologic behavior. AIM: The current study investigates the relationship of Bcl-2 and E-cadherin immunoexpression to histopathological and clinical prognostic factors in oral squamous cell carcinomas, and correlates E-cadherin/Bcl-2 ratio with Bryne's patterns of invasion...
March 14, 2017: Journal of Oral Pathology & Medicine
Harumi Mizuki, Ryosuke Abe, Shintaro Kogi, Toshinari Mikami
BACKGROUND: Oral lichen planus (OLP) is a T-cell-mediated inflammatory disease; however, its exact etiology is unknown. Hyperkeratosis is often observed in OLP lesions. Previous studies have revealed the localization of Mycoplasma salivarium in the epithelial cells of oral leukoplakia with hyperkeratosis. Herein, we investigated the presence of M. salivarium in OLP tissue by immunohistochemistry to determine the causative factor of OLP. METHODS: Forty-one formalin-fixed, paraffin-embedded samples obtained from 31 patients with OLP were examined...
March 10, 2017: Journal of Oral Pathology & Medicine
Fabio Grizzi, Daniel Yiu, Sanja Stifter
The article by Dave et al. (1) aimed to correlate the expression of Mediator of DNA Damage Checkpoint Protein 1 (MDC1) with clinicopathological parameters and to evaluate its prognostic significance in 100 patients with oral squamous cell carcinoma (OSCC). Today, the main goal of oncological research remains the translation of newly discovered biochemical and histopathological biomarkers into clinical practice. Biomarkers can be mainly included in four classes: a) diagnostic biomarkers, b) prognostic biomarkers, c) predictive biomarkers, and d) surveillance biomarkers...
March 7, 2017: Journal of Oral Pathology & Medicine
Kyu-Young Oh, Kyoung-Ok Hong, Young-Sung Huh, Jae-Il Lee, Seong-Doo Hong
BACKGROUND: SOX7, a member of the SOX family of transcription factors, acts as a tumor suppressor in multiple cancers. Downregulation of SOX7 has been reported in advanced tumors and correlates with poor prognosis. The aims of this study were to investigate the effects of SOX7 on cell proliferation, invasion, and colony formation in oral squamous cell carcinoma (OSCC) cells and to evaluate the effectiveness of SOX7 protein as a prognostic indicator for OSCC patients. METHODS: oral squamous cell carcinoma (OSCC) cell lines were treated with SOX7 small interfering RNA or SOX7 peptide, and their effects on cell proliferation, invasiveness, and colony formation were investigated by proliferation, in vitro invasion, and clonogenic assays...
March 7, 2017: Journal of Oral Pathology & Medicine
Hellen Bandeira de Pontes Santos, Márcia Cristina da Costa Miguel, Leão Pereira Pinto, Manuel Antonio Gordón-Núñez, Pollianna Muniz Alves, Cassiano Francisco Weege Nonaka
BACKGROUND: Multinucleated giant cell (MGC) reactions have been identified in several malignancies, but their frequency and significance in lower lip squamous cell carcinoma (SCC) are not established. This study evaluated the MGC reactions and their association with clinicopathological parameters in lower lip SCCs. The polarization profile of these cells (M1 or M2 macrophages) was also assessed. METHODS: The presence and distribution of MGC reactions in high-power fields (400×) were evaluated in hematoxylin/eosin-stained histological sections of 91 lower lip SCCs...
February 15, 2017: Journal of Oral Pathology & Medicine
Liviu Feller, Razia A G Khammissa, Johan Lemmer
Chronic ulcerative stomatitis is an immune-mediated mucocutaneous disorder characterized clinically by erosions or ulcers. Most cases are limited to the mouth. The histopathological features are non-specific or mimic those of oral lichen planus, and studies by immunoflorescent microscopy are essential for definitive diagnosis. The defining immunopathogenic mechanism is the binding of IgG to the nuclear protein deltaNp63alpha of keratinocytes in the basal and parabasal cell layers of the oral stratified epithelium...
February 10, 2017: Journal of Oral Pathology & Medicine
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