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Journal of Oral Pathology & Medicine

Rafael Carneiro Ortiz, Nathália Martins Lopes, Nadia Ghinelli Amôr, José Burgos Ponce, Cláudia Kliemann Schmerling, Vanessa Soares Lara, Raquel Ajub Moyses, Camila Oliveira Rodini
BACKGROUND: Tumour metastasis has been associated with cancer stem cells, a small population with stem-like cells properties, higher rate of migration and metastatic potential compared to cells from the tumour bulk. Our aim was to evaluate the immunoexpression of the putative cancer stem cell biomarkers ALDH1 and CD44 in primary tumour and corresponding metastatic lymph nodes. METHODS: Tumour tissue specimens (n=50) and corresponding metastatic lymph nodes (n=25) were surgically obtained from 50 patients with oral squamous cell carcinoma and submitted to immunohistochemistry...
May 23, 2018: Journal of Oral Pathology & Medicine
Jorge J De La Chapa, Prajjal Kanti Singha, Debbie R Lee, Cara B Gonzales
BACKGROUND: Thymol is a Transient Receptor Potential Ankyrin Subtype 1 channel, (TRPA1) agonist found in thyme and oregano. Thymol has antioxidant, anti-inflammatory, and antimicrobial properties; thus thymol is added to many commercially available products including Listerine mouthwash. Thymol is also cytotoxic to HL-60 (acute promyelotic leukemia) cells in vitro. Therefore, we evaluated the effects of thymol against oral squamous cell carcinoma (OSCC) and its anticancer mechanism-of-action...
May 19, 2018: Journal of Oral Pathology & Medicine
Iakov Shimanovich, Julia Marie Nitz, Mareike Witte, Detlef Zillikens, Christian Rose
BACKGROUND: Mucous membrane pemphigoid (MMP) is an autoimmune subepithelial blistering disease with predominant involvement of mucosal surfaces. It is usually diagnosed by direct immunofluorescence microscopy of frozen biopsies, demonstrating linear deposits of complement, IgG or IgA along the basement membrane. The aim of the present study was to investigate the utility of immunohistochemistry on formalin-fixed, paraffin-embedded tissue biopsies for the diagnosis of MMP and to compare its sensitivity to that of direct immunofluorescence microscopy...
May 12, 2018: Journal of Oral Pathology & Medicine
P J Thomson
Squamous cell carcinoma arising from oral mucosal epithelium remains a lethal and deforming disease due to tumour invasion, oro-facial destruction, cervical lymph node metastasis and ultimate blood-borne dissemination. Worldwide, 300,000 new cases are seen each year, with a recent and significant rise in incidence affecting particularly the young. In order to rationalize perspectives on preventive strategies in oral cancer management, this paper addresses a number of fundamental questions regarding carcinogenesis: Proliferation - what epithelial cell changes precede tumour development? Position - why are certain oral sites so predisposed to cancer? Progression - why do some precursor lesions progress to invasive carcinoma and others do not? Prediction - how can we predict individual patient and/or lesion behaviour to prevent disease progression? By improving our understanding of oral carcinogenesis, can we thereby facilitate more effective primary, secondary and tertiary preventive strategies and ultimately reduce the global burden of OSCC? This article is protected by copyright...
May 12, 2018: Journal of Oral Pathology & Medicine
Sharada Sawant, Chetan Ahire, Harsh Dongre, Shriya Joshi, Sayli Jamghare, Pallavi Rane, Shubhada Kane, Devendra Chaukar
BACKGROUND: Availability of reliable methods distinguishing high risk recurrent tumours from regressive tumours prior to surgery could help in better management of the disease. Present study was aimed to estimate pre-surgical serum CD44 concentration and assess the possibility of using it as a non-invasive prognostic tool in oral cancer. METHODS: ELISA was performed on pre-surgical serum samples from 64 primary oral cancer patients and 16 healthy individuals to estimate soluble CD44 levels...
May 12, 2018: Journal of Oral Pathology & Medicine
Bruno Ramos Chrcanovic, Carolina Cavalieri Gomes, Ricardo Santiago Gomez
PURPOSE: To review all available data published on central giant cell lesion (CGCL) of the jaws into a comprehensive analysis of its clinical/radiologic features, with emphasis on the predictive factors associated with its recurrence. METHODS: An electronic search was undertaken in 5 databases (February/2018), looking for reporting cases of CGCLs. RESULTS: 365 publications were included, comprising 2270 lesions. CGCLs were more prevalent in women and the mandible...
May 11, 2018: Journal of Oral Pathology & Medicine
Dyah Listyarifah, Mikko T Nieminen, Laura K Mäkinen, Caj Haglund, Daniel Grenier, Valtteri Häyry, Dan Nordström, Marcela Hernandez, Tülay Yucel-Lindberg, Taina Tervahartiala, Mari Ainola, Timo Sorsa, Jaana Hagström
BACKGROUND: Certain periodontopathogenic bacteria have been linked to cancers. Treponema denticola (Td) is associated with severe periodontitis. Chymotrypsin-like proteinase (CTLP), a major virulence factor of Td, can degrade various host proteins and peptides, and modulate inflammatory responses. However the role of Td in the tongue carcinogenesis remains unknown. This study aimed to investigate the presence of Td-CTLP in early-stage mobile tongue squamous cell carcinoma (MTSCC) and its relation to clinical and pathological characteristics...
May 10, 2018: Journal of Oral Pathology & Medicine
José Alcides Almeida de Arruda, João Luiz Gomes Carneiro Monteiro, Lucas Guimarães Abreu, Leni Verônica de Oliveira Silva, Lauren Frenzel Schuch, Mariana Saturnino de Noronha, Gerhilde Callou, Amália Moreno, Ricardo Alves Mesquita
BACKGROUND: The aim of this study was to integrate the available data published on calcifying odontogenic cyst (COC), dentinogenic ghost cell tumor (DGCT) and ghost cell odontogenic carcinomas (GCOC) into a comprehensive analysis of their clinicoradiological features, treatment and recurrence. MATERIALS AND METHODS: An electronic search with no publication date restriction was undertaken in October 2017 in the following databases: PubMed, Medline Ovid, Web of Science and Scopus...
May 8, 2018: Journal of Oral Pathology & Medicine
Daniel Araki Ribeiro
I read the recent paper of Lima and colleagues published in Journal of Oral Pathology & Medicine entitled ''Effect of HIV infection in the micronuclei frequency on the oral mucosa" (1) with much interest. In this article, the authors failed to detect an increase of micronuclei on oral mucosa cells from HIV positive patients submitted to HAART therapy (1). However, this study has some important issues that must be addressed for data interpretation with accuracy. This article is protected by copyright...
May 8, 2018: Journal of Oral Pathology & Medicine
Jianming Zhang, Jingjing Quan, Yongyuan Ren, Mengshan Chen, Jie Yang, Xu Zhang
BACKGROUND: The aim of this study was to investigate the roles of keratin 4 (KRT4) gene in the development of human white sponge nevus (WSN). METHODS: Transgenic mice were created using the microinjection method with pcDNA3.1 vectors expressing KRT4 wild-type (WT) gene and E520K mutation. Polymerase chain reaction (PCR) and western blotting were used to identify the genotype of transgenic founders and their filial generations. Expression of KRT4 in mouse oral mucosa was characterized by immunohistochemistry (IHC), and the whole epithelium layer of transgenic mice was observed by using transmission electron microscope (TEM)...
May 8, 2018: Journal of Oral Pathology & Medicine
Fernanda Weber Mello, Andressa Fernanda Paza Miguel, Kamile Leonardi Dutra, André Luís Porporatti, Saman Warnakulasuriya, Eliete Neves Silva Guerra, Elena Riet Correa Rivero
Oral potentially malignant disorders (OPMD) are chronic conditions, which have a higher risk of transformation to oral squamous cell carcinoma. The aim of this systematic review and meta-analysis was to answer the question: "What is the prevalence of oral potentially malignant disorders among adults?". Studies reporting the prevalence of these conditions (leukoplakia, erythroplakia, oral submucous fibrosis, and actinic cheilitis) were selected, only studies in which a clinical assessment and histopathological confirmation were performed were included...
May 8, 2018: Journal of Oral Pathology & Medicine
Lady Paola Aristizabal Arboleda, Iva Loureiro Hoffmann, Izilda Aparecida Cardinalli, Alan Roger Santos-Silva, Regina Maria Holanda de Mendonça
BACKGROUND: The incidence of pediatric head and neck cancer (PHNC) is increasing worldwide, especially when compared with childhood cancer in general. However, there is still a lack of knowledge about the demographic profile of such patients across the globe. Therefore, the aim of this study was to describe demographic, topographic and histopathological features of pediatric head and neck cancer patients from a single Brazilian institution. METHODS: Medical records were retrospectively reviewed for all cancer cases diagnosed from 1986 to 2016 affecting patients aged 19-years and younger...
May 4, 2018: Journal of Oral Pathology & Medicine
Gururaj Arakeri, Abdulsalam S Aljabab, Peter A Brennan
We would like to thank Dr Gondivkar and colleagues for their kind comments.1 We appreciate their concern in assessing psycho-social impairment in oral submucous fibrosis (OSMF) and to develop a patient-centered and bio-psychosocial approach to patient care. For this approach, Dr Gondivkar et al suggested the use of a quality of life (QoL) tool along with our recently proposed TFM staging.2 While we agree this this is an excellent idea, we suspect that there would be some practical difficulty with QoL in OSMF which may prevent its regular use with our proposed TFM staging...
May 2, 2018: Journal of Oral Pathology & Medicine
Fumihiko Sato, Jun Akiba, Akihiko Kawahara, Yoshiki Naito, Takeharu Ono, Yorihiko Takase, Kazuya Murata, Hideyuki Abe, Tomohiko Yamaguchi, Hiroaki Miyoshi, Yushi Abe, Yutaro Mihara, Masahiko Tanikawa, Momoko Akashi, Hirofumi Kurose, Hirohito Umeno, Hirohisa Yano
BACKGROUND: Salivary duct carcinoma (SDC) is a rare tumor occurring in the salivary gland. SDC is a highly aggressive tumor and its prognosis is extremely poor. Effective treatments in advanced SDC have not yet been established. Recently, immune checkpoint inhibitors have paved the way for the treatment of various malignancies. We examined the expressions of programed death ligand (PD-L) 1/PD-L2 and programed death (PD-1), and the correlation of clinicopathological findings. METHODS: We examined 18 cases of SDC and conducted immunohistochemical staining using formalin-fixed paraffin-embedded full-face sections...
May 2, 2018: Journal of Oral Pathology & Medicine
Gabriela Tonini Peterle, Lucas Lima Maia, Leonardo Oliveira Trivilin, Mayara Mota de Oliveira, Joaquim Gasparini Dos Santos, Suzanny Oliveira Mendes, Elaine Stur, Lidiane Pignaton Agostini, Lília Alves Rocha, Raquel Ajub Moysés, Patrícia Maluf Cury, Fábio Daumas Nunes, Iúri Drumond Louro, Marcelo Dos Santos, Adriana Madeira Álvares da Silva
BACKGROUND: In oral squamous cell carcinoma (OSCC), the HIF-1 complex promotes the expression of genes involved in specific mechanisms of cell survival under hypoxic conditions, such as plasminogen activator inhibitor-1 (PAI-1), carbonic anhydrase 9 (CAIX) and vascular endothelial growth factor A (VEGFA). The study aimed to investigate the presence and prognostic value of PAI-1, CAIX, and VEGFA in OSCC. MATERIALS AND METHODS: Immunohistochemistry was used to analyze the expressions of these proteins in 52 tumoral tissue samples of patients with OSCC, surgically treated and followed by a minimum of 24 months after surgery...
April 25, 2018: Journal of Oral Pathology & Medicine
Bi-He Zhang, Ning Huang, Jia-Yu Shi, Bing Shi, Zhong-Lin Jia
Non-syndromic cleft lip with or without cleft palate (NSCL/P) is a complex disorder, it results from both of the genetic modifiers and environmental factors, with genetic modifiers contributed to it more than environmental factors. GWASs studies made great progress in identifying the candidate genes for NSCL/P, but the findings needs to be replicated in other populations. In this study, we selected eleven SNPs from recent GWASs and GWAS meta-analysis to investigate their associations among 308 NSCL/P trios (134 non-syndromic cleft lip only (NSCLO) trios and 174 non-syndromic cleft lip with cleft palate (NSCLP) trios) from Han Chinese population...
April 23, 2018: Journal of Oral Pathology & Medicine
Shailesh M Gondivkar, Amol R Gadbail, Sachin C Sarode, Gargi S Sarode, Shankargouda Patil
We read with great interest an article titled 'TFM classification and staging of oral submucous fibrosis: a new proposal' published by Arakeri et al.1 One could sense the virtuous intention for finding much needed comprehensive grading system for one of the most dreadful pathologies in Asian countries, oral submuous fibrosis (OSF). Trismus, fibrosis and malignant transformation are the three most aptly chosen parameters, as they not only reflect patient's disease severity but also are predictors of malignant potential...
April 23, 2018: Journal of Oral Pathology & Medicine
Jitender Prasad, Binita Goswami, Srinivas H Gowda, Nikhil Gupta, Shilpa Kumar, Kiran Agarwal, Pravesh Mehra, Bindiya K Pahuja, Anju Chauhan
BACKGROUND: Oral squamous cell carcinoma (OSCC) is a cancer of the oral cavity that is a major health problem in India. There is an urgent need to identify biomarkers that have prognostic significance. We studied HIF1 α levels as well as single nucleotide polymorphism of HIF1α gene in cancer and healthy controls. METHODS: Fifty newly diagnosed OSCC patients and 50 age and sex matched healthy control were included in the study. Serum concentrations of HIF1 α were measured by sandwich ELISA; whereas HIF1 α gene polymorphism study was done using restriction enzyme digestion by HpH I...
April 20, 2018: Journal of Oral Pathology & Medicine
Meysam Ganjibakhsh, Roshanak Monshizadeh, Ahmad Nasimian, Pouyan Aminishakib, Parvaneh Farzaneh, Sahar Tavakoli Shiraji, Ata Garajei, Sedigheh Rahrotaban, Fereshteh Baghaei, Neda Sadat Gohari
BACKGROUND: In recent decades, anti-angiogenic treatment strategy has been well-described in cancer treatment. The anti-angiogenic activity of both Bevacizumab and Aflibercept have been researched on ten previously established primary Oral Squamous Cell Carcinoma (OSCC) cells of an Iranian population with different levels of purity, in an attempt to find the most effective anti-angiogenic targeted drug. METHODS: To investigate and compare the effect of Bevacizumab and Aflibercept on Vascular Endothelial Growth Factor (VEGF) secretion of ten primary OSCC cells, cell proliferation and viability were assessed by ELISA and MTT assays...
April 19, 2018: Journal of Oral Pathology & Medicine
P J Thomson, M L Goodson, D R Smith
BACKGROUND: Clinically identifiable potentially malignant disorders (PMD) precede oral squamous cell carcinoma development. Oral lichenoid lesions (OLL) and proliferative verrucous leukoplakia (PVL) are specific precursor lesions believed to exhibit both treatment resistance and a high risk of malignant transformation (MT). METHODS: A retrospective review of 590 PMD patients treated in Northern England by CO2 laser surgery between 1996 and 2014 was carried out. Lesions exhibiting lichenoid or proliferative verrucous features were identified from the patient database and their clinico-pathological features and outcome post-treatment determined at the study census date of 31 December 2014...
April 16, 2018: Journal of Oral Pathology & Medicine
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