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Journal of Oral Pathology & Medicine

Xiaotong Wang, Hongquan Song, Xiaohui Jiao, Yanru Hao, Wei Zhang, Yuwei Gao, Yong Li, Na Mi, Jiaqun Yan
BACKGROUND: Nonsyndromic orofacial cleft (NSOC) is a common craniofacial deformity among newborns. The GREM1 gene is correlated with orofacial development. The aim of our study was to investigate the association between a single-nucleotide polymorphism in the GREM1 gene and this malformation in the Chinese population. METHODS: The SNaPshot mini sequencing technique was used to genotype the locus rs1258763 of the GREM1 gene in 331 patients with NSOC and 271 individuals in a control group...
November 17, 2017: Journal of Oral Pathology & Medicine
Abdulhameed Husain, Omar Kujan, Camile S Farah
OBJECTIVES: This systematic review aimed to analyze the published evidence for the use of oral brush cytology for the early detection of oral cancer and oral potentially malignant disorders (OPMDs). METHODS: Literature was systematically searched through several databases: MEDLINE, EMBASE, PubMed, SCOPUS, Cochrane Library and Web of Science. Additional review was performed through cross checks on the bibliographies of selected articles. The inclusion criteria involved studies assessing the utility of oral brush cytology on human tissues and its applications in the diagnosis, screening or surveillance of oral cancer or OPMDs...
November 12, 2017: Journal of Oral Pathology & Medicine
Jie Liu, Nikos Mattheos, Cheng Su, Chuanxi Deng, Nanyu Luo, Zekun Wang, Hua Tang
OBJECTIVE: This study was intended to investigate the effects of Icariin on the healing of tooth extraction sites under systemic administration of Zoledronic and Dexamethasone. METHOD: Thirty female rats underwent bilateral ovariectomy and were randomly assigned to 5 groups: SS group received weekly injection of saline while ZD, ZD+LICA, ZD+MICA and ZD+HICA groups received Zoledronic with Dexamethasone for 8 weeks. One week later, mandibular first molars were extracted in all groups...
November 11, 2017: Journal of Oral Pathology & Medicine
Robert O Greer, Jeffrey Eskendri, Paul Freedman, Moni Ahmadian, Aline Murakami-Walter, Marileila Varella-Garcia
BACKGROUND: Glandular odontogenic cyst (GOC) demonstrates a significant predilection toward localized biologic aggressiveness and recurrence. GOC shares certain histopathologic features with intraosseous mucoepidermoid carcinoma (IMEC). The current investigation evaluates a group of recurrent, biologically aggressive GOCs to determine if any cases demonstrated unique histologic features or Mastermind - like2 (MAML2) rearrangements common to IMEC. METHODS: Microscopic slides from eleven previously diagnosed GOGs were stained with hematoxylin and eosin and assessed by two study participants for ten classic histopathologic features required to establish a diagnosis of GOC...
November 9, 2017: Journal of Oral Pathology & Medicine
Olga Stasikowska-Kanicka, Małgorzata Wągrowska-Danilewicz, Marian Danilewicz
BACKGROUND: The prognosis of human malignancies has been shown to depend on immunological parameters, such as macrophage polarization (M1 and M2). In this study, we identify the phenotype of macrophages, and investigate an involvement of infiltrated T cells that participate in the polarization of macrophages, in oral leukoplakia (OLK), and oral squamous cell carcinoma (OSCC). METHODS: Immunohistochemical method was used to examine the number of CD68(+) , CD163(+) (M2), iNOS(+) (M1) macrophages, and CD4(+) , CD8(+) , CCR4(+) (Th2), CCR5(+) (Th1) cells in 102 cases of OSCC: without metastases-OSCC M(-) (n = 54), and with metastases-OSCC M(+) (n = 48), 23 cases of OLK, and 18 control cases...
November 6, 2017: Journal of Oral Pathology & Medicine
Jin Hou, Fangyuan Wang, Xiaohao Liu, Mengyang Song, Xuemin Yin
OBJECTIVES: Tumor-derived exosomes (TDE) have been shown to participate in different steps of the dissemination of cancer cells. However, the role of salivary adenoid cystic carcinoma-derived (SACC-derived) exosomes had not been documented in SACC. The study aims to explore the functions of SACC-derived TDE in SACC progression and investigate potential mechanisms. METHODS: Salivary adenoid cystic carcinoma cell line SACC-83 was used to generate TDE. Afterward, SACC-83 or HUVECs were cocultured with or without TDE...
October 23, 2017: Journal of Oral Pathology & Medicine
Qi Zeng, Xi Yang, Xiaobing Chen, Juan Xia, Bin Cheng, Xiaoan Tao
BACKGROUND: We recently reported that the CC chemokine ligand 2 (CCL2)-CC receptor 2 (CCR2) axis was involved in the pathogenesis of oral lichen planus (OLP). However, the exact mechanism for the high expression of CCL2 in OLP specimens is not clear. Therefore, this study was designed to investigate the potential role of the toll-like receptor 4 (TLR-4) pathway in overproduction of CCL2 in OLP lesions. METHODS: Immunohistochemical staining and real-time RT-PCR were used to detect TLR-4, CCL2, and CCR2 expression in OLP lesions...
October 23, 2017: Journal of Oral Pathology & Medicine
Eleni-Marina Kalogirou, Evangelia P Piperi, Konstantinos I Tosios, Evangelos Tsiambas, Galinos Fanourakis, Alexandra Sklavounou
BACKGROUND: Type I interferon activation is a hallmark event in Sjögren's syndrome. L1 retroelements stimulate plasmacytoid dendritic cells, activating the type I interferons, and are regulated by various mechanisms, including the APOBEC3 deaminases. As L1s are potential trigger factors in autoimmunity, we aimed to investigate the immunohistochemical localization of L1 ORF2 and its inhibitor APOBEC3B protein in minor salivary glands of Sjögren's syndrome patients. METHODS: Twenty minor salivary gland-tissue samples from 20 Sjögren's syndrome patients, classified according to Tarpley's histological criteria, and 10 controls were evaluated for L1 ORF2p and APOBEC3B expression via immunohistochemistry...
October 23, 2017: Journal of Oral Pathology & Medicine
Mauricio Rocha Dourado, Carine Ervolino de Oliveira, Iris Sawazaki-Calone, Elias Sundquist, Ricardo D Coletta, Tuula Salo
BACKGROUND: Rho-associated coiled-coil kinase 2 (ROCK2) is an oncoprotein that controls cytoskeleton organization and acts as prognostic marker in different types of solid tumors. ROCK2 overexpression is also observed in cancer-associated fibroblasts (CAF), which suggests its relevance within the tumor microenvironment. This study aimed to access the prognostic value of ROCK2 in oral squamous cell carcinomas (OSCC) and its association with CAF density. METHODS: ROCK2 immunohistochemical analysis was applied in 93 OSCC samples from 2 centers in Brazil and Finland...
October 20, 2017: Journal of Oral Pathology & Medicine
Helvécio Marangon Junior, Priscila Laiza Rubim Leão, Victória Vasconcellos Moreira Melo, Ângela Braga Caixeta, Paulo Eduardo Alencar Souza, Maria Cássia Ferreira de Aguiar, Martinho Campolina Rebello Horta
BACKGROUND: Tumor budding is a morphological marker of cancer invasion, defined as the presence of isolated or small clusters of neoplastic cells at the tumor invasive front. This study aimed to evaluate the association between intensity of tumor budding and cell proliferation in oral squamous cell carcinoma (OSCC). METHODS: Immunohistochemistry was employed in 163 OSCC samples to detect the cell proliferation marker Ki-67 and multi-cytokeratin (to identify OSCC cells in tumor budding evaluation)...
October 20, 2017: Journal of Oral Pathology & Medicine
Maria Westin, Elham Rekabdar, Lena Blomstrand, Per Klintberg, Mats Jontell, Jairo Robledo-Sierra
BACKGROUND: White sponge nevus is a rare autosomal dominant disorder that affects the non-keratinised stratified squamous epithelium. Mutations in the genes that encode mucosa-specific keratins 4 and 13 are strongly linked to the manifestation of white sponge nevus. This study involved mutational analysis of the genes encoding keratin-4 and keratin-13 in two Swedish families with white sponge nevus. METHODS: The diagnosis of white sponge nevus was based on disease history, clinical characteristics of the lesions and, in the majority of the cases, histopathological examination...
October 19, 2017: Journal of Oral Pathology & Medicine
Thaís Dos Santos Fontes Pereira, João Artur Ricieri Brito, André Luiz Sena Guimarães, Carolina Cavaliéri Gomes, Júlio Cesar Tanos de Lacerda, Wagner Henriques de Castro, Roney Santos Coimbra, Marina Gonçalves Diniz, Ricardo Santiago Gomez
BACKGROUND: Cemento-ossifying fibroma (COF) is a benign fibro-osseous neoplasm of uncertain pathogenesis, and its treatment results in morbidity. MicroRNAs (miRNA) are small non-coding RNAs that regulate gene expression and may represent therapeutic targets. The purpose of the study was to generate a comprehensive miRNA profile of COF compared to normal bone. Additionally, the most relevant pathways and target genes of differentially expressed miRNA were investigated by in silico analysis...
October 15, 2017: Journal of Oral Pathology & Medicine
Onur Bender, Mehmet Gunduz, Sadik Cigdem, Omer Faruk Hatipoglu, Muradiye Acar, Mesut Kaya, Reidar Grenman, Esra Gunduz, Kadriye Serife Ugur
BACKGROUND: Genetic factors play a large role in cancer and thus there is a great desire to understand the effects of different genes in cancer and to also develop gene therapy for better treatments. Therefore, the development of alternative diagnosis and therapy modalities are of utmost importance. The aim of our study is to illuminate the role of ESM1 (endothelial cell specific molecule-1, also known as Endocan) in proliferation and migration of head and neck cancer, thus helping to pave the way for new treatment modalities and predictive biomarkers...
October 11, 2017: Journal of Oral Pathology & Medicine
Simone Belobrov, Alyssa M Cornall, Richard J Young, Kendrick Koo, Christopher Angel, David Wiesenfeld, Danny Rischin, Suzanne M Garland, Michael McCullough
BACKGROUND: The aim of the present study was to identify the presence and frequency of human papillomavirus (HPV) nucleic acid in p16 positive oral squamous cell carcinomas (OSCC), to assess if the virus were transcriptionally active, and to assess the utility of p16 overexpression as a surrogate marker for HPV in OSCC. METHODS: Forty-six OSCC patients treated between 2007 and 2011 with available formalin-fixed paraffin embedded (FFPE) specimens were included. Twenty-three patients were positive for p16 by immunohistochemistry (IHC) and these were matched with 23 patients with p16 negative tumours...
October 11, 2017: Journal of Oral Pathology & Medicine
Ana Carolina Uchoa Vasconcelos, Felipe Martins Silveira, Ana Paula Neutzling Gomes, Sandra Beatriz Chaves Tarquinio, Ana Paula Veras Sobral, José Alcides Almeida de Arruda, Leorik Pereira da Silva, Marcia Maria Fonseca da Silveira, Larissa Ferreira Barbosa, Camila de Nazaré Alves de Oliveira Kato, Filipe Jaeger, Tarcília Aparecida da Silva, Ricardo Alves Mesquita
BACKGROUND: Odontogenic myxoma (OM) is an uncommon neoplasm of the jaws. Considering the importance of defining the relative incidence and demographic profile of these lesions in South America, the aim of this study was to analyze the clinical and imagiological features of OM from three South American oral pathology services and to discuss these findings in light of the literature. METHODS: Data regarding age, gender, anatomic site, and imagiological features from 85 cases of OM were collected...
October 6, 2017: Journal of Oral Pathology & Medicine
Claire Egloff-Juras, Aurélie Gallois, Julia Salleron, Vincent Massard, Gilles Dolivet, Julie Guillet, Bérengère Phulpin
BACKGROUND: Osteonecrosis of the jaw is a very delicate side effect of Denosumab. The aim of this retrospective study was to assess the occurrence rate of Denosumab-related osteonecrosis of the jaw (DRONJ) at the Cancer Institute of Lorraine (ICL) and to highlight necrosis risk factors. METHODS: To that purpose, we analyzed the medical records of 249 consecutive patients treated with Denosumab at the ICL during the past 5 years. Patients who received orofacial radiotherapy or a previous treatment with a bisphosphonate were excluded...
October 4, 2017: Journal of Oral Pathology & Medicine
Aline Fernanda Cruz, Renata Gonçalves de Resende, Júlio César Tanos de Lacerda, Núbia Braga Pereira, Leonardo Augusto Melo, Marina Gonçalves Diniz, Carolina Cavalieri Gomes, Ricardo Santiago Gomez
BACKGROUND: The oral lichen planus is a chronic inflammatory disease. Although its aetiology is not well understood, the role of T lymphocytes in its inflammatory events is recognised. Identifying the epigenetic mechanisms involved in the pathogenesis of this immune-mediated condition is fundamental for understanding the inflammatory reaction that occurs in the disease. The purpose of this work was to evaluate the methylation pattern of 21 immune response-related genes in the different clinical forms of oral lichen planus...
October 4, 2017: Journal of Oral Pathology & Medicine
Yujia Wang, Sheng Chen, Yanhong Ni, Derek Magee, Yumei Pu, Qian Zhou, Zhiyong Wang, Lei Zhang, Xiaofeng Huang, Qingang Hu
OBJECTIVES: Margin status and invasion pattern are prognostic factors for oral tongue squamous cell carcinoma (OTSCC). Current methods to identify these factors are limited to 2D observation; it is necessary to explore 3D reconstruction with whole-mount sample to improve the accuracy of analysis. This study aimed to study the tissue preparation, section generation, and 3D reconstruction with whole-mount OTSCC specimen. STUDY DESIGN: Two OTSCC samples were retrieved from Nanjing Stomatological Hospital, Medical School of Nanjing University...
September 28, 2017: Journal of Oral Pathology & Medicine
Alessandro Menna Alves, Leonardo Francisco Diel, Marcelo Lazzaron Lamers
Oral Squamous Cell Carcinoma (OSCC) presents a tumor microenvironment rich in inflammatory cells. Depending on the stimulus, macrophages can polarize in M1 or M2 profile, where M1 acts as proinflammatory and antitumor, and M2 is anti-inflammatory and shows protumor activity. Several studies have shown that macrophages are important to the prognosis of patients with different types of cancer. Our aim was to conduct a systematic review to evaluate the role of macrophages in the prognosis of OSCC patients. A search in the Pubmed, Scopus, and ISI Web of Knowledge database was performed, and it was included only studies that evaluated the importance of macrophages in the prognosis of OSCC patients...
September 21, 2017: Journal of Oral Pathology & Medicine
Sara Ferreira Dos Santos Costa, Peter A Brennan, Ricardo Santiago Gomez, Eduardo Rodrigues Fregnani, Alan Roger Santos-Silva, Manoela Domingues Martins, Gilberto de Castro-Junior, Siavash Rahimi, Felipe Paiva Fonseca
Oral squamous cell carcinoma (OSCC) is the commonest subtype of oral cancer, mainly affecting older patients. It used to be a rare disease among individuals younger than 40 years, but recently increased incidences in this age group are being reported worldwide. The pathogenesis of OSCC affecting young patients remains controversial and the well known etiological factors for oral cancer, tobacco and alcohol use, are believed to play a minor role in the carcinogenesis of the neoplasm, suggesting that the etiology and the molecular basis of OSCC may differ between younger and older patients...
September 18, 2017: Journal of Oral Pathology & Medicine
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