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Journal of Neuropsychiatry and Clinical Neurosciences

Wai Kwong Tang, Xiang Xin Liu, Huajun Liang, Yang Kun Chen, Winnie Chiu Wing Chu, Anil T Ahuja, Jill Abrigo, Vincent Chung Tong Mok, Gabor S Ungvari, Ka Sing Wong, Gianfranco Spalletta
The role of the infarct location in the development of poststroke agitation (PSA) is largely unknown. This study examined the association between the locations of infarcts and PSA at 9 months following the index stroke in 213 patients with the Chinese version of the Neuropsychiatric Inventory. Compared with the non-PSA group, PSA patients had a higher number and volume of acute pontine infarcts. Ventral pontine and lateral cerebellar infarcts were independent predictors of PSA in the multivariate analysis.
October 6, 2016: Journal of Neuropsychiatry and Clinical Neurosciences
Rachel Galioto, Geoffrey Tremont, Andrew S Blum, W Curt LaFrance, Cara L Crook, Jennifer D Davis
This study examined the contribution of depression to reduced executive functioning in temporal lobe epilepsy (TLE) using three groups: TLE only (TLE; N=29), TLE+depression (TLE+DEP) (N=22), and nonneurologic participants with depression (DEP; N=31). Participants completed the Delis-Kaplan Executive Function System. Individuals with TLE performed worse than the DEP group on many tests of executive functions. Among the TLE participants, those with depression demonstrated poorer executive functioning. These findings support the notion that depression may further contribute to executive difficulties in individuals with TLE...
October 6, 2016: Journal of Neuropsychiatry and Clinical Neurosciences
Rituparna Maiti, Biswa Ranjan Mishra, Debasish Hota
Repetitive transcranial magnetic stimulation (rTMS), a noninvasive, neuromodulatory tool, has been used to reduce craving in different substance use disorders. There are some studies that have reported conflicting and inconclusive results; therefore, this meta-analysis was conducted to evaluate the effect of high-frequency rTMS on craving in substance use disorder and to investigate the reasons behind the inconsistency across the studies. The authors searched clinical trials from MEDLINE, Cochrane databases, and International Clinical Trials Registry Platform...
October 6, 2016: Journal of Neuropsychiatry and Clinical Neurosciences
Mario F Mendez, Andrew R Carr, Pongsatorn Paholpak
Behavioral variant frontotemporal dementia (bvFTD) may result in psychotic-like speech without other psychotic features. The authors identified a bvFTD subgroup with pressure of speech, tangentiality, derailment, clanging/rhyming, and punning associated with the right anterior temporal atrophy and sparing of the left frontal lobe.
October 6, 2016: Journal of Neuropsychiatry and Clinical Neurosciences
Sverre Georg Sæther, Morten Schou, Winfried Stoecker, Bianca Teegen, Kathrin Borowski, Arne Vaaler, Daniel Kondziella, Solveig Klæbo Reitan
Paraneoplastic neurological disorders associated with onconeural antibodies often appear with neuropsychiatric symptoms. To study the prevalence of onconeural antibodies in patients admitted to acute psychiatric inpatient care, the serum of 585 such patients was tested for antibodies targeting MOG, GLRA1B, DPPX, GRM1, GRM5, DNER, Yo, ZIC4, GAD67, amphiphysin, CV2, Hu, Ri, Ma2, and recoverin. Only one sample was positive (antirecoverin IgG). The present findings suggest that serum onconeural antibody positivity is rare among patients acutely admitted for inpatient psychiatric care...
August 31, 2016: Journal of Neuropsychiatry and Clinical Neurosciences
Anna Pink, Scott A Przybelski, Janina Krell-Roesch, Gorazd B Stokin, Rosebud O Roberts, Michelle M Mielke, Kathleen A Spangehl, David S Knopman, Clifford R Jack, Ronald C Petersen, Yonas E Geda
The authors conducted a cross-sectional study to investigate the association between anxiety symptoms and cortical thickness, as well as amygdalar volume. A total of 1,505 cognitively normal participants, aged ≥70 years, were recruited from the Mayo Clinic Study of Aging in Olmsted County, Minnesota, on whom Beck Anxiety Inventory and 3T brain MRI data were available. Even though the effect sizes were small in this community-dwelling group of participants, anxiety symptoms were associated with reduced global cortical thickness and reduced thickness within the frontal and temporal cortex...
August 31, 2016: Journal of Neuropsychiatry and Clinical Neurosciences
Joseph J Cooper, Jon Grant
Structural brain lesions can be a rare cause of refractory psychiatric symptoms. The analysis of such cases may lead to insights into psychiatric neurobiology. Here we present a case of a dronabinol-responsive obsessive-compulsive syndrome after thalamic infarct.
August 19, 2016: Journal of Neuropsychiatry and Clinical Neurosciences
Michael L Alosco, Jesse Mez, Neil W Kowall, Thor D Stein, Lee E Goldstein, Robert C Cantu, Douglas I Katz, Todd M Solomon, Patrick T Kiernan, Lauren Murphy, Bobak Abdolmohammadi, Daniel Daneshvar, Philip H Montenigro, Christopher J Nowinski, Robert A Stern, Ann C McKee
This study conducted a preliminary examination on cognitive reserve (CR) as a modifier of symptom expression in subjects with autopsy-confirmed chronic traumatic encephalopathy (CTE). The sample included 25 former professional football players neuropathologically diagnosed with CTE stage III or IV. Next of kin interviews ascertained age at cognitive and behavioral/mood symptom onset and demographic/athletic characteristics. Years of education and occupational attainment defined CR. High occupational achievement predicted later age at cognitive (p=0...
August 19, 2016: Journal of Neuropsychiatry and Clinical Neurosciences
Vincent Meille, Bruno Verges, Laurence Lalanne, Lysiane Jonval, Laurence Duvillard, Jean-Christophe Chavet-Gelinier, Bernard Bonin, Benoit Trojak
Some studies have reported that repetitive transcranial magnetic stimulation (rTMS) applied to the dorsolateral prefrontal cortex (DLPFC) is able to induce changes in the hypothalamic-pituitary axis in subjects with major depression. The causes of these neuroendocrine effects are unknown and deserve to be studied. The authors monitored neuroendocrine hormones in 15 subjects with major depression treated by 1-Hz rTMS on the right DLPFC and explored a correlation with mood improvement. Unlike previous studies, no changes in serum cortisol, prolactin, and thyroid hormone levels were found...
August 19, 2016: Journal of Neuropsychiatry and Clinical Neurosciences
M Soledad Cepeda, Eva G Katz, Clair Blacketer
To assess the association of probiotics with depression, a large population-based cross-sectional study was conducted. National Health and Nutrition Examination Survey adult participants from 2005 through 2012 were included. Exposure was defined as having consumed any probiotic food or supplement on any of the interview days. Subjects were classified as depressed if Patient Health Questionnaire scores were ≥10. Of the 18,019 subjects included, 14.11% consumed probiotics. Unadjusted analysis suggested that subjects who consumed probiotics had lower odds of depression (OR=0...
August 19, 2016: Journal of Neuropsychiatry and Clinical Neurosciences
Adalia H Jun-O'Connell, Ankur Butala, Idanis Berrios Morales, Nils Henninger, Kristina M Deligiannidis, Nancy Byatt, Carolina Ionete
Clinical observations of mood instability in multiple sclerosis (MS) have led to the hypothesis that bipolar disorder (BD) may be more prevalent in persons with MS than in the general population. This cross-sectional study assesses the prevalence of BD among patients with MS using standardized psychiatric diagnostic interviews and evaluates quality of life. This study demonstrates a higher prevalence of BD in patients with MS compared with the general population. It also reveals the negative impact of BD on quality of life, raises the concern that BD can occur before the onset of neurological symptoms in MS, and suggests that, in some cases, BD may delay diagnosis of MS...
August 19, 2016: Journal of Neuropsychiatry and Clinical Neurosciences
Pantelis Maiovis, Panagiotis Ioannidis, Georgios Gerasimou, Anna Gotzamani-Psarrakou, Dimitrios Karacostas
Severity assessment scales for frontotemporal lobar degeneration (FTLD) have been recently introduced. In the present study, the authors examined whether the FTLD-modified Clinical Dementia Rating (FTLD-CDR) scale and the Frontotemporal Dementia Rating Scale (FRS) correlated with regional brain perfusion in Greek FTLD patients. A total of 47 behavioral variant frontotemporal dementia (bvFTD) patients and 33 primary progressive aphasia (PPA) patients were assessed for demographic data, cognitive reserve (CR), and severity of dementia and underwent brain single-photon emission computed tomography...
July 15, 2016: Journal of Neuropsychiatry and Clinical Neurosciences
Jesús M Ruiz-Idiago, Misericordia Floriach, Cèlia Mareca, Raymond Salvador, José Luis López-Sendón, Verónica Mañanés, Esther Cubo, Natividad Mariscal, Esteban Muñoz, Pilar Santacruz, María F Noguera, Laura Vivancos, Pedro Roy, Edith Pomarol-Clotet, Salvador Sarró
A prospective, observational multicenter study was carried out assessing neuropsychiatric symptoms in a sample of 117 subjects in order to validate the Spanish version of the Problem Behaviors Assessment-Short (PBA-s). The psychometric properties of this version were analyzed. Inter- and intra-rater reliability were good: the mean weighted Cohen's kappa was 0.90 for severity scores and 0.93 for frequency scores. Four factors accounting for 56% of the total variance were identified after an exploratory factor analysis: apathy, irritability, depression, and perseveration...
July 15, 2016: Journal of Neuropsychiatry and Clinical Neurosciences
Ricardo Salazar, Alok Kumar Dwivedi, Donald R Royall
In this cross-sectional study, we examined the neuropsychiatric profile of mild cognitive impairment (MCI) and Alzheimer's disease (AD) using the Neuropsychiatric Inventory Questionnaire (NPI-Q). Data were available on 875 controls, 339 MCI cases, and 975 AD participants. Surprisingly, differences in neuropsychiatric symptom (NPS) severity by ethnicity in subjects with AD, but not with MCI, were found. More so, in Hispanics with AD, a higher frequency in most of the individual NPI-Q symptom items of the scale was observed, except for apathy...
July 15, 2016: Journal of Neuropsychiatry and Clinical Neurosciences
Hochang B Lee, Mei Ling Song, Brian B Koo, Yong Won Cho
Frequently co-occurring restless legs syndrome (RLS) and periodic limb movements during sleep (PLMS) are postulated to share common pathophysiology. The authors compared clinical characteristics and polysomnography (PSG) parameters among 155 idiopathic, untreated RLS patients who were stratified into three groups based on periodic limb movement index (PLMI). The authors found that RLS patients without PLMS (PLMI <5) had higher depression and anxiety scores, a lower total arousal index, longer latency to REM, and a higher spontaneous arousal frequency on PSG than RLS patients with PLMS...
July 15, 2016: Journal of Neuropsychiatry and Clinical Neurosciences
Altaib Al Yassin, Bichun Ouyang, Richard Temes
Although survival has dramatically improved following aneurysmal subarachnoid hemorrhage (aSAH), the reasons for persistent high rates of unemployment in this population remain unknown. Retrospective review for medical records of patients with aSAH admitted to Rush University Medical Center was undertaken. Multivariate logistic regression models were used to test the association of either depression or anxiety with the 6-month employment status. Among the 29 patients who developed depression or anxiety, 86...
July 15, 2016: Journal of Neuropsychiatry and Clinical Neurosciences
Jonathan Laugharne, Claire Kullack, Christopher W Lee, Tracy McGuire, Simone Brockman, Peter D Drummond, Sergio Starkstein
The authors investigated the impact of eye movement desensitization and reprocessing (EMDR) and prolonged exposure (PE) on the volumes of the amygdala and hippocampus, structures known to be important in fear conditioning, in 20 patients with posttraumatic stress disorder (PTSD). Patients were randomly allocated to either EMDR or PE. Volumes were assessed before and after treatment via magnetic resonance imaging (MRI). Both groups showed significant improvements in PTSD symptoms. Left amygdala mean volume increased significantly following EMDR treatment only...
June 3, 2016: Journal of Neuropsychiatry and Clinical Neurosciences
Jia Y Zhang, Anthony Feinstein
Detecting cognitive dysfunction in a busy traumatic brain injury (TBI) clinic is challenging given the length of conventional assessments and the need for psychometric expertise. The authors report the utility of a 10-minute, easily administered computerized battery that is more sensitive than the Montreal Cognitive Assessment in detecting cognitive impairments in people with a TBI.
June 3, 2016: Journal of Neuropsychiatry and Clinical Neurosciences
Kristopher Grajny, Harshini Pyata, Katherine Spiegel, Elizabeth H Lacey, Shihui Xing, Carl Brophy, Peter E Turkeltaub
Damage to the brain's mood regulation systems may contribute to poststroke depression. This study examines relationships between depression symptoms and psychosocial factors and then uses multivariate lesion-symptom mapping to localize depression symptoms in people with chronic left hemisphere stroke. Depression symptoms relate inversely to education and directly to physical disability. Damage in the left dorsolateral prefrontal cortex is associated with greater depression symptoms. These results demonstrate a neurological contribution to depression symptoms in chronic left hemisphere stroke and provide evidence of convergent biological mechanisms for poststroke depression symptoms and major depression with regard to left dorsolateral prefrontal cortex dysfunction...
June 3, 2016: Journal of Neuropsychiatry and Clinical Neurosciences
Christopher M Filley
The term white matter dementia (WMD) was introduced in 1988 to highlight the role of white matter in the development of dementia. As the concept has been refined with new insights into the structure and function of normal and abnormal white matter, research has expanded to consider normal cognition, network connectivity, novel treatment ideas, and the etiopathogenesis of neurodegenerative dementia. Emerging data are also identifying new opportunities for dementia prevention by avoidance of acquired vascular and traumatic white matter insults...
June 3, 2016: Journal of Neuropsychiatry and Clinical Neurosciences
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