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Journal of Neuropsychiatry and Clinical Neurosciences

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https://www.readbyqxmd.com/read/27899053/cognitive-performance-in-subjects-with-multiple-sclerosis-is-robustly-influenced-by-gender-in-canonical-correlation-analysis
#1
Sue-Jin Lin, Janet Lam, Samantha Beveridge, Irene Vavasour, Anthony Traboulsee, David K B Li, Alex MacKay, Martin McKeown, Brenda Kosaka
The authors explored the relations between clinical/demographic characteristics and performance on a neuropsychological battery (eight tests) in a cohort (N=46) of multiple sclerosis (MS) subjects. Findings resulted from a secondary analysis of a study examining the relationships between imaging biomarkers in MS and cognitive tasks of executive functioning. The objective was to determine whether the overlapping test results could be judiciously combined and associated with clinical/demographic variables. Canonical-correlation analysis (CCA) was utilized, and it was found that differences between performance on untimed tests, and the sum of performance on timed Trail-Making Tests, Parts A and B, best matched clinical/demographic variables, and gender was the most important feature...
November 30, 2016: Journal of Neuropsychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/27899052/initial-response-to-transcranial-magnetic-stimulation-treatment-for-depression-predicts-subsequent-response
#2
Michael S Kelly, Albino J Oliveira-Maia, Margo Bernstein, Adam P Stern, Daniel Z Press, Alvaro Pascual-Leone, Aaron D Boes
This study provides support for the hypothesis that treatment response to an initial course of repetitive transcranial magnetic stimulation (rTMS) for depression predicts the magnitude of response to a subsequent course of rTMS in the setting of symptom relapse.
November 30, 2016: Journal of Neuropsychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/27899051/anxiety-levels-are-independently-associated-with-cognitive-performance-in-an-australian-multiple-sclerosis-patient-cohort
#3
Karen Ribbons, Rodney Lea, Peter W Schofield, Jeannette Lechner-Scott
Neurological and psychological symptoms in multiple sclerosis can affect cognitive function. The objective of this study was to explore the relationship between psychological measures and cognitive performance in a patient cohort. In 322 multiple sclerosis patients, psychological symptoms were measured using the Depression Anxiety and Stress Scale, and cognitive function was evaluated using Audio Recorded Cognitive Screen. Multifactor linear regression analysis, accounting for all clinical covariates, found that anxiety was the only psychological measure to remain a significant predictor of cognitive performance (p<0...
November 30, 2016: Journal of Neuropsychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/27899050/suspected-delirium-predicts-the-thoroughness-of-catatonia-evaluation
#4
Joan Roig Llesuy, M Justin Coffey, Kristen C Jacobson, Joseph J Cooper
Although commonly linked to psychiatric disorders, catatonia is frequently identified secondary to neurological and general medical conditions (GMCs). The present study aimed to characterize the diagnostic workup of cases of catatonia in a general hospital setting. The authors performed a retrospective chart review of 54 cases of catatonia, over 3 years. Clinical suspicion of comorbid delirium was the strongest predictor of a more thorough general medical workup. Attribution of catatonia to a psychiatric etiology was associated with significantly less diagnostic workup...
November 30, 2016: Journal of Neuropsychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/27852165/association-of-bdnf-val66met-polymorphism-with-parkinson-s-disease-and-depression-and-anxiety-symptoms
#5
Fernanda Carvalho Cagni, Clarissa Loureiro das Chagas Campêlo, Daniel Gomes Coimbra, Mayara Rodrigues Barbosa, Luiz Gonzaga Oliveira Júnior, Antônio Braz Silva Neto, Alessandra Mussi Ribeiro, Clécio de Oliveira Godeiro Júnior, Tiago Gomes de Andrade, Regina Helena Silva
An association between Parkinson's disease (PD) and brain-derived neurotrophic factor (BDNF) was suggested by several studies, with contradictory results. BDNF is necessary for the survival of dopaminergic neurons in substantia nigra. Val66Met is a common polymorphism of the BDNF gene that affects cognitive and motor processes. The authors studied 104 Brazilian patients with PD and 96 control participants. The G/G genotype was significantly associated with depression and anxiety symptoms and development of PD...
November 17, 2016: Journal of Neuropsychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/27852164/transcranial-magnetic-stimulation-modulates-resting-eeg-functional-connectivity-between-the-left-dorsolateral-prefrontal-cortex-and-limbic-regions-in-medicated-patients-with-treatment-resistant-depression
#6
Shinsuke Kito, Takashi Hasegawa, Akihiro Takamiya, Takamasa Noda, Kazuyuki Nakagome, Teruhiko Higuchi, Yoshihiko Koga
High-frequency left prefrontal repetitive transcranial magnetic stimulation (rTMS) has been shown to have efficacy in treatment-resistant depression. However, the effects of rTMS on functional connectivity are still not clear. To examine changes in functional connectivity before and after rTMS, resting EEG of 14 patients with treatment-resistant depression was recorded twice at baseline and at week 4, respectively. The EEG data were analyzed using the standardized low-resolution brain electromagnetic tomography (sLORETA)...
November 17, 2016: Journal of Neuropsychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/27829318/cognitive-effects-of-rasagiline-in-mild-to-moderate-stage-parkinson-s-disease-without-dementia
#7
Laura L Frakey, Joseph H Friedman
The authors studied the effects of rasagiline on cognition in a sample of 50 nondemented patients with mild to moderate Parkinson's disease (PD) using a double-blind, placebo controlled design. Cognition and motor symptoms were assessed at baseline and after 6 months of receiving either rasagiline or placebo. Participants receiving rasagiline showed improvement in their motor symptoms of PD compared to participants receiving placebo. No significant changes in performance on neuropsychological measures of cognition were observed between the groups...
November 10, 2016: Journal of Neuropsychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/27707197/location-of-acute-infarcts-and-agitation-and-aggression-in-stroke
#8
Wai Kwong Tang, Xiang Xin Liu, Huajun Liang, Yang Kun Chen, Winnie Chiu Wing Chu, Anil T Ahuja, Jill Abrigo, Vincent Chung Tong Mok, Gabor S Ungvari, Ka Sing Wong, Gianfranco Spalletta
The role of the infarct location in the development of poststroke agitation (PSA) is largely unknown. This study examined the association between the locations of infarcts and PSA at 9 months following the index stroke in 213 patients with the Chinese version of the Neuropsychiatric Inventory. Compared with the non-PSA group, PSA patients had a higher number and volume of acute pontine infarcts. Ventral pontine and lateral cerebellar infarcts were independent predictors of PSA in the multivariate analysis.
October 6, 2016: Journal of Neuropsychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/27707196/depressive-symptoms-contribute-to-executive-deficits-in-temporal-lobe-epilepsy
#9
Rachel Galioto, Geoffrey Tremont, Andrew S Blum, W Curt LaFrance, Cara L Crook, Jennifer D Davis
This study examined the contribution of depression to reduced executive functioning in temporal lobe epilepsy (TLE) using three groups: TLE only (TLE; N=29), TLE+depression (TLE+DEP) (N=22), and nonneurologic participants with depression (DEP; N=31). Participants completed the Delis-Kaplan Executive Function System. Individuals with TLE performed worse than the DEP group on many tests of executive functions. Among the TLE participants, those with depression demonstrated poorer executive functioning. These findings support the notion that depression may further contribute to executive difficulties in individuals with TLE...
October 6, 2016: Journal of Neuropsychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/27707195/effect-of-high-frequency-transcranial-magnetic-stimulation-on-craving-in-substance-use-disorder-a-meta-analysis
#10
Rituparna Maiti, Biswa Ranjan Mishra, Debasish Hota
Repetitive transcranial magnetic stimulation (rTMS), a noninvasive, neuromodulatory tool, has been used to reduce craving in different substance use disorders. There are some studies that have reported conflicting and inconclusive results; therefore, this meta-analysis was conducted to evaluate the effect of high-frequency rTMS on craving in substance use disorder and to investigate the reasons behind the inconsistency across the studies. The authors searched clinical trials from MEDLINE, Cochrane databases, and International Clinical Trials Registry Platform...
October 6, 2016: Journal of Neuropsychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/27707194/psychotic-like-speech-in-frontotemporal-dementia
#11
Mario F Mendez, Andrew R Carr, Pongsatorn Paholpak
Behavioral variant frontotemporal dementia (bvFTD) may result in psychotic-like speech without other psychotic features. The authors identified a bvFTD subgroup with pressure of speech, tangentiality, derailment, clanging/rhyming, and punning associated with the right anterior temporal atrophy and sparing of the left frontal lobe.
October 6, 2016: Journal of Neuropsychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/27578448/onconeural-antibodies-in-acute-psychiatric-inpatient-care
#12
Sverre Georg Sæther, Morten Schou, Winfried Stoecker, Bianca Teegen, Kathrin Borowski, Arne Vaaler, Daniel Kondziella, Solveig Klæbo Reitan
Paraneoplastic neurological disorders associated with onconeural antibodies often appear with neuropsychiatric symptoms. To study the prevalence of onconeural antibodies in patients admitted to acute psychiatric inpatient care, the serum of 585 such patients was tested for antibodies targeting MOG, GLRA1B, DPPX, GRM1, GRM5, DNER, Yo, ZIC4, GAD67, amphiphysin, CV2, Hu, Ri, Ma2, and recoverin. Only one sample was positive (antirecoverin IgG). The present findings suggest that serum onconeural antibody positivity is rare among patients acutely admitted for inpatient psychiatric care...
August 31, 2016: Journal of Neuropsychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/27578447/cortical-thickness-and-anxiety-symptoms-among-cognitively-normal-elderly-persons-the-mayo-clinic-study-of-aging
#13
Anna Pink, Scott A Przybelski, Janina Krell-Roesch, Gorazd B Stokin, Rosebud O Roberts, Michelle M Mielke, Kathleen A Spangehl, David S Knopman, Clifford R Jack, Ronald C Petersen, Yonas E Geda
The authors conducted a cross-sectional study to investigate the association between anxiety symptoms and cortical thickness, as well as amygdalar volume. A total of 1,505 cognitively normal participants, aged ≥70 years, were recruited from the Mayo Clinic Study of Aging in Olmsted County, Minnesota, on whom Beck Anxiety Inventory and 3T brain MRI data were available. Even though the effect sizes were small in this community-dwelling group of participants, anxiety symptoms were associated with reduced global cortical thickness and reduced thickness within the frontal and temporal cortex...
August 31, 2016: Journal of Neuropsychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/27539378/refractory-ocd-due-to-thalamic-infarct-with-response-to-dronabinol
#14
Joseph J Cooper, Jon Grant
Structural brain lesions can be a rare cause of refractory psychiatric symptoms. The analysis of such cases may lead to insights into psychiatric neurobiology. Here we present a case of a dronabinol-responsive obsessive-compulsive syndrome after thalamic infarct.
August 19, 2016: Journal of Neuropsychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/27539377/cognitive-reserve-as-a-modifier-of-clinical-expression-in-chronic-traumatic-encephalopathy-a-preliminary-examination
#15
Michael L Alosco, Jesse Mez, Neil W Kowall, Thor D Stein, Lee E Goldstein, Robert C Cantu, Douglas I Katz, Todd M Solomon, Patrick T Kiernan, Lauren Murphy, Bobak Abdolmohammadi, Daniel Daneshvar, Philip H Montenigro, Christopher J Nowinski, Robert A Stern, Ann C McKee
This study conducted a preliminary examination on cognitive reserve (CR) as a modifier of symptom expression in subjects with autopsy-confirmed chronic traumatic encephalopathy (CTE). The sample included 25 former professional football players neuropathologically diagnosed with CTE stage III or IV. Next of kin interviews ascertained age at cognitive and behavioral/mood symptom onset and demographic/athletic characteristics. Years of education and occupational attainment defined CR. High occupational achievement predicted later age at cognitive (p=0...
August 19, 2016: Journal of Neuropsychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/27539376/effects-of-transcranial-magnetic-stimulation-on-the-hypothalamic-pituitary-axis-in-depression-results-of-a-pilot-study
#16
Vincent Meille, Bruno Verges, Laurence Lalanne, Lysiane Jonval, Laurence Duvillard, Jean-Christophe Chavet-Gelinier, Bernard Bonin, Benoit Trojak
Some studies have reported that repetitive transcranial magnetic stimulation (rTMS) applied to the dorsolateral prefrontal cortex (DLPFC) is able to induce changes in the hypothalamic-pituitary axis in subjects with major depression. The causes of these neuroendocrine effects are unknown and deserve to be studied. The authors monitored neuroendocrine hormones in 15 subjects with major depression treated by 1-Hz rTMS on the right DLPFC and explored a correlation with mood improvement. Unlike previous studies, no changes in serum cortisol, prolactin, and thyroid hormone levels were found...
August 19, 2016: Journal of Neuropsychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/27539375/microbiome-gut-brain-axis-probiotics-and-their-association-with-depression
#17
M Soledad Cepeda, Eva G Katz, Clair Blacketer
To assess the association of probiotics with depression, a large population-based cross-sectional study was conducted. National Health and Nutrition Examination Survey adult participants from 2005 through 2012 were included. Exposure was defined as having consumed any probiotic food or supplement on any of the interview days. Subjects were classified as depressed if Patient Health Questionnaire scores were ≥10. Of the 18,019 subjects included, 14.11% consumed probiotics. Unadjusted analysis suggested that subjects who consumed probiotics had lower odds of depression (OR=0...
August 19, 2016: Journal of Neuropsychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/27539374/the-prevalence-of-bipolar-disorders-and-association-with-quality-of-life-in-a-cohort-of-patients-with-multiple-sclerosis
#18
Adalia H Jun-O'Connell, Ankur Butala, Idanis Berrios Morales, Nils Henninger, Kristina M Deligiannidis, Nancy Byatt, Carolina Ionete
Clinical observations of mood instability in multiple sclerosis (MS) have led to the hypothesis that bipolar disorder (BD) may be more prevalent in persons with MS than in the general population. This cross-sectional study assesses the prevalence of BD among patients with MS using standardized psychiatric diagnostic interviews and evaluates quality of life. This study demonstrates a higher prevalence of BD in patients with MS compared with the general population. It also reveals the negative impact of BD on quality of life, raises the concern that BD can occur before the onset of neurological symptoms in MS, and suggests that, in some cases, BD may delay diagnosis of MS...
August 19, 2016: Journal of Neuropsychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/27417072/frontotemporal-lobar-degeneration-modified-clinical-dementia-rating-ftld-cdr-scale-and-frontotemporal-dementia-rating-scale-frs-correlation-with-regional-brain-perfusion-in-a-series-of-ftld-patients
#19
Pantelis Maiovis, Panagiotis Ioannidis, Georgios Gerasimou, Anna Gotzamani-Psarrakou, Dimitrios Karacostas
Severity assessment scales for frontotemporal lobar degeneration (FTLD) have been recently introduced. In the present study, the authors examined whether the FTLD-modified Clinical Dementia Rating (FTLD-CDR) scale and the Frontotemporal Dementia Rating Scale (FRS) correlated with regional brain perfusion in Greek FTLD patients. A total of 47 behavioral variant frontotemporal dementia (bvFTD) patients and 33 primary progressive aphasia (PPA) patients were assessed for demographic data, cognitive reserve (CR), and severity of dementia and underwent brain single-photon emission computed tomography...
July 15, 2016: Journal of Neuropsychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/27417071/spanish-validation-of-the-problem-behaviors-assessment-short-pba-s-for-huntington-s-disease
#20
Jesús M Ruiz-Idiago, Misericordia Floriach, Cèlia Mareca, Raymond Salvador, José Luis López-Sendón, Verónica Mañanés, Esther Cubo, Natividad Mariscal, Esteban Muñoz, Pilar Santacruz, María F Noguera, Laura Vivancos, Pedro Roy, Edith Pomarol-Clotet, Salvador Sarró
A prospective, observational multicenter study was carried out assessing neuropsychiatric symptoms in a sample of 117 subjects in order to validate the Spanish version of the Problem Behaviors Assessment-Short (PBA-s). The psychometric properties of this version were analyzed. Inter- and intra-rater reliability were good: the mean weighted Cohen's kappa was 0.90 for severity scores and 0.93 for frequency scores. Four factors accounting for 56% of the total variance were identified after an exploratory factor analysis: apathy, irritability, depression, and perseveration...
July 15, 2016: Journal of Neuropsychiatry and Clinical Neurosciences
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