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International Journal of Immunopathology and Pharmacology

Tomas Soukup, Jana Nekvindova, Martin Dosedel, Jindra Brtkova, Jan Toms, Drahomira Bastecka, Petr Bradna, Jiri Vlcek, Petr Pavek
We describe Caucasian monozygotic twin brothers with rheumatoid arthritis (RA) and discuss influence of predictors to methotrexate (MTX) outcome treatment. Single nucleotide polymorphisms (SNPs) of the MTX metabolic pathways were genotyped. Twins have multiple mutations: a CC mutation of SNP 1298A>C in methylenetetrahydrofolate reductase (MTHFR) gene, CC mutations of three SNPs in the adenosine receptor gene ADORA2A (rs3761422_4217241T>C, rs2267076_4221164T>C, rs2236624_4226593T>C), and a heterozygous genotype in SNPs ATIC_rs2372536_347C>G, MTHFD1_rs2236225_1958G>A...
October 21, 2016: International Journal of Immunopathology and Pharmacology
Quan Lin, Yan Li, Duo Zhang, Hongjuan Jin
Decreasing levels of cytokines are associated with better responses to therapies, while increasing levels are related to progression or recurrence and decreased survival. NF-κB's role in the cell cycle and its ubiquity are only stressed out by the evidence for the importance of activation (aberrant activation in the majority of cancers) of both canonical and non-canonical pathways in advanced basal cell carcinomas (aBCCs), a subset of basal cell carcinoma (BCC). NF-κB acts through its canonical, or classical, form activated by interleukin-1 (IL-1), regulates cytoprotective, innate, and adaptive immune responses...
October 19, 2016: International Journal of Immunopathology and Pharmacology
Hye-Youn Son, Vasso Apostolopoulos, Chul-Woo Kim
Tumor immunotherapy, capable of inducing both cellular and humoral immune responses, is an attractive treatment strategy for cancer. It has been reported that the inactivation of cell-mediated immunity by hyper-activation of humoral immunity-referred to as immune deviation-does not inhibit tumor growth. We investigated the ability of several adjuvants to elicit Thomsen-Friedenreich (T/Tn)-specific humoral immunity while avoiding immune deviation and conferring protection against tumorigenesis. T/Tn (9:1) antigen was purified from blood type O erythrocytes donated by healthy Korean volunteers...
October 19, 2016: International Journal of Immunopathology and Pharmacology
Jurate Stanevičiūtė, Daiva Urbonienė, Angelija Valančiūtė, Ingrida Balnytė, Astra Vitkauskienė, Brigita Grigalevičienė, Donatas Stakišaitis
The study aim was to investigate the effect of dichloroacetate (DCA) on thymus and the thymocyte cycle in rats. Wistar male gonad-intact and castrated rats (4-5 weeks) were investigated in the following groups: (1) control; (2) treated with DCA; and (3) treated with the DCA and sodium valproate (NaVP) combination. Rats were treated for 4 weeks with DCA 200 mg/kg/day alone and 300 mg/kg/day of NaVP plus 200 mg/kg/day of DCA (every second week, beginning with NaVP). After the experiment, the thymus was weighted, and the thymus lobe was taken for thymocyte flow cytometry...
October 14, 2016: International Journal of Immunopathology and Pharmacology
Chethan Gejjalagere Honnappa, Unnikrishnan Mazhuvancherry Kesavan
Inflammatory diseases are complex, multi-factorial outcomes of evolutionarily conserved tissue repair processes. For decades, non-steroidal anti-inflammatory drugs and cyclooxygenase inhibitors, the primary drugs of choice for the management of inflammatory diseases, addressed individual targets in the arachidonic acid pathway. Unsatisfactory safety and efficacy profiles of the above have necessitated the development of multi-target agents to treat complex inflammatory diseases. Current anti-inflammatory therapies still fall short of clinical needs and the clinical trial results of multi-target therapeutics are anticipated...
October 5, 2016: International Journal of Immunopathology and Pharmacology
Yan Ding, Xiao-Li Xiong, Li-Shan Zhou, Su-Qi Yan, Huan Qin, Hua-Rong Li, Ling-Ling Zhang, Peng Chen, Cong Yao, Zhi-Xia Jiang, Lei Zhao
The aim of this study is to investigate Emodin on alleviating intrahepatic cholestasis by regulation of liver farnesoid X receptor (FXR) pathway. Cell and animal models of intrahepatic cholestatis were established. Biochemical tests and histomorphology were performed. The messenger RNA (mRNA) and protein expression of FXR, small heterodimer partner (SHP), uridine diphosphate glucuronosyltransferase 2 family polypeptide B4 (UGT2B4), and bile salt export pump (BSEP) was detected. As a result, compared with the model group, the serum levels of biochemical test were significantly lower in the Emodin group (P <0...
October 5, 2016: International Journal of Immunopathology and Pharmacology
Mohamed H Mahmoud, Gamal Badr, Nashwa A El Shinnawy
The prevalence of health problems in the offspring of pregnant diabetic mothers has recently been verified. Therefore, the present study was designed to investigate the influence of dietary camel whey protein (CWP), administered as a supplement to streptozotocin (STZ)-induced diabetic pregnant mice, on the efficiency of the immune system of the offspring. Three groups of female mice (n = 10) were used: non-diabetic control mice, diabetic mice, and diabetic mice orally administered CWP during the pregnancy and lactation periods...
September 30, 2016: International Journal of Immunopathology and Pharmacology
Vijay Pal Singh, Kunal Pratap, Juhi Sinha, Koundinya Desiraju, Devika Bahal, Ritushree Kukreti
Animal experiments that are conducted worldwide contribute to significant findings and breakthroughs in the understanding of the underlying mechanisms of various diseases, bringing up appropriate clinical interventions. However, their predictive value is often low, leading to translational failure. Problems like translational failure of animal studies and poorly designed animal experiments lead to loss of animal lives and less translatable data which affect research outcomes ethically and economically. Due to increasing complexities in animal usage with changes in public perception and stringent guidelines, it is becoming difficult to use animals for conducting studies...
September 30, 2016: International Journal of Immunopathology and Pharmacology
Fei Liu, Dong Xu, Kefeng Zhang, Jian Zhang
This study aims to explore the effects of tranexamic acid on the coagulation indexes of patients undergoing heart valve replacement surgery under the condition of cardiopulmonary bypass (CPB). One hundred patients who conformed to the inclusive criteria were selected and divided into a tranexamic acid group and a non-tranexamic acid group. They all underwent heart valve replacement surgery under CPB. Patients in the tranexamic acid group were intravenously injected with 1 g of tranexamic acid (100 mL) at the time point after anesthesia induction and before skin incision and at the time point after the neutralization of heparin...
September 30, 2016: International Journal of Immunopathology and Pharmacology
Haiming Zheng, Zhanjun Lu, Ruhua Wang, Niwei Chen, Ping Zheng
Inflammatory bowel disease (IBD) has been reported as an important inducer of colorectal cancer (CRC). The most malignant IBD-associated CRC type has been highlighted as colitis-associated cancer (CAC). However, lack of CAC cases and difficulties of the long follow-up research have challenged researchers in molecular mechanism probing. Here, we established pre-CAC mouse models (dextran sulfate sodium [DSS] group and azoxymethane [AOM] group) and CAC mouse model (DSS/AOM group) to mimic human CAC development through singly or combinational treatment with DSS and AOM followed by disease activity index analysis...
September 30, 2016: International Journal of Immunopathology and Pharmacology
L Ricciardi
No abstract text is available yet for this article.
September 27, 2016: International Journal of Immunopathology and Pharmacology
Athanasios Tragiannidis, Nikolaos Gombakis, Maria Papageorgiou, Emmanuel Hatzipantelis, Theodotis Papageorgiou, Maria Hatzistilianou
Treatment-related myelodysplastic syndrome (t-MDS)/acute myeloid leukemia (AML) is a devastating early or late complication of treatment for childhood cancer related with a significant morbidity and mortality. We retrospectively studied survivors of childhood cancer. Overall, 287 patients were recorded in the databases and we identified three (1.04%) with t-MDS. The primary cancer diagnoses were Langerhans cell histiocytosis (one patient) and acute lymphoblastic leukemia (ALL; two patients). The mean age of patients was 12...
September 19, 2016: International Journal of Immunopathology and Pharmacology
Hye-Youn Son, Yong-Hyun Jeon, June-Key Chung, Chul-Woo Kim
In assessing the effectiveness of DNA vaccines, it is important to monitor: (1) the kinetics of target gene expression in vivo; and (2) the movement of cells that become transfected with the plasmid DNA used in the immunization of a subject. In this study, we used, as a visual imaging marker, expression of the transfected human sodium/iodide symporter (hNIS) gene, which enhances intracellular radio-pertechnetate (TcO4-) accumulation. After intradermal (i.d.) and systemic injection of mice with pcDNA-hNIS and radioactive Technetium-99m (Tc-99m), respectively, whole-body images were obtained by nuclear scintigraphy...
September 9, 2016: International Journal of Immunopathology and Pharmacology
Pablo Del Villar-Guerra, Blanca Moreno Vicente-Arche, Sara Castrillo Bustamante, Carlos Santana Rodríguez
One of the most used cephalosporins in clinical practice is cefuroxime axetil. Anaphylaxis due to the administration of cefuroxime is considered a rare event. We report a case of anaphylactic reaction after the administration of cefuroxime in a child who had tolerated the drug in past exposures. Diagnostic workup is recommended for all patients with at least a moderate anaphylactic reaction (hypotension, tachycardia, bronchial hyperreactivity). This should include a detailed history of the event, previous allergies, and underlying conditions...
August 16, 2016: International Journal of Immunopathology and Pharmacology
Pei-Hao Wen, Dong-Yu Wang, Jia-Kai Zhang, Zhi-Hui Wang, Jie Pan, Xiao-Yi Shi, Han Yang, Shui-Jun Zhang, Wen-Zhi Guo
Kruppel-like factor 6 (KLF6) as a novel tumor suppressive gene participates in multiple biological behaviors and plays an important role in regulating tumor cell growth and invasion. However, the functions of KLF6 in hepatocellular carcinoma (HCC) remain poorly understood. The expression level of KLF6 was examined by immunohistochemical assay in human HCC tissues, and KLF6-overexpressed HCC cells (SMCC-7721 and HepG2) were used for evaluating cell proliferation and invasion by MTT and Transwell assays. A subcutaneous HCC tumor model was established for assessing tumor growth in vivo...
August 10, 2016: International Journal of Immunopathology and Pharmacology
Qianhui Qiu, Mimi Xu, Chuan Lu, Jianjun Chen, Shaohua Chen, Weijia Kong, Hong Han
The purpose of this prospective, open-IV clinical trial was to assess the safety and efficacy differences between Rush immunotherapy (RIT) and conventional immunotherapy in Chinese allergic rhinitis (AR) patients. The trial involved 174 patients with AR. They were divided into two groups according to their preference of therapy: RIT or conventional immunotherapy. A total of 162 patients completed a 1-year treatment course. For safety and effectiveness evaluation, the local and systemic adverse reactions were recorded throughout the initial phase of both groups...
August 10, 2016: International Journal of Immunopathology and Pharmacology
Said Said Elshama, Ayman El-Meghawry El-Kenawy, Hosam-Eldin Hussein Osman
Atorvastatin is considered to be one of the most commonly used of all statins anti-hyperlipidemic drugs despite the fact that there is much controversy about its safety. Its therapeutic use becomes severely limited by the hazards of inducing myotoxicity. Curcumin is one of the safe spices that have chemoprotection and cytoprotection effects against endogenous and exogenous noxious stimuli. This study investigates the effect of curcumin on atorvastatin sub-chronic use-induced myotoxicity in rats by the assessment of serum creatinine phosphokinase, lactic acid dehydrogenase, myoglobin, troponin, potassium, creatinine, and histopathological changes of skeletal, smooth, and cardiac muscles by light and electron microscope examination...
August 9, 2016: International Journal of Immunopathology and Pharmacology
H Rasheed, Mhm El-Komy, R A Hegazy, H I Gawdat, A M AlOrbani, O G Shaker
Sirtuins (SIRT) have been regarded as culprits in the pathogenesis of various diseases. Their exact role has not been explained. This study aimed to assess the expression of SIRT1, SIRT6, tumor necrosis factor (TNF)-α, and interferon (IFN)-γ in psoriatic patients. Thirty psoriatic patients and 22 controls were enrolled. Clinical examination and Psoriasis Area and Severity Index (PASI) were obtained. Two skin biopsies (lesional, peri-lesional) and one from controls were obtained. Tissue levels of SIRT1, SIRT6, TNF-α, and IFN-γ were measured using ELISA...
August 5, 2016: International Journal of Immunopathology and Pharmacology
Sara Torretta, Paola Marchisio, Vittorio Rinaldi, Michele Gaffuri, Carla Pascariello, Lorenzo Drago, Elena Baggi, Lorenzo Pignataro
Hyaluronic acid (HA) treatment has been successfully performed in patients with recurrent upper airway infections or rhinitis. The aim of this study was to assess the efficacy and safety of the topical nasal administration of an HA-based compound by investigating its effects in children with recurrent or chronic middle ear inflammations and chronic adenoiditis. A prospective, single-blind, 1:1 randomised controlled study was performed to compare otoscopy, tympanometry and pure-tone audiometry in children which received the daily topical administration of normal 0...
September 2016: International Journal of Immunopathology and Pharmacology
Matthew J Rogatzki, Scott E Soja, Colleen A McCabe, Ryanne E Breckenridge, Jeffrey L White, Julien S Baker
The goals of this study were to determine if the biomarkers of head injury, NSE and S100B, increased in serum following an American football game. Serum creatine kinase (CK) and cortisol levels were also measured to determine muscle damage and stress caused by the football game. NSE, S100B, CK, and cortisol were measured in the serum of 17 football players before and after a collegiate junior varsity football game. No head injuries were reported by the players, athletic training staff, or coaches yet both NSE (Pre-game: 7...
September 2016: International Journal of Immunopathology and Pharmacology
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