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International Journal of Immunopathology and Pharmacology

Hui Dong, Wei Jiang, Hongquan Chen, Shui Jiang, Yunshu Zang, Bo Yu
MicroRNAs (miRNAs/miRs) play vital roles in various immune diseases including systemic lupus erythematosus (SLE). The current study aimed to assess the role of miR-145 in interleukin-6 (IL-6)-treated HaCaT cells under ultraviolet B (UVB) irradiation and further explore the potential regulatory mechanism. HaCaT cells were pretreated with IL-6 and then exposed to UVB to assess the effect of IL-6 on sensitivity of HaCaT cells to UVB irradiation. The levels of miR-145 and MyD88 were altered by transfection and the transfected efficiency was verified by quantitative reverse transcription polymerase chain reaction (qRT-PCR)/western blot analysis...
January 2018: International Journal of Immunopathology and Pharmacology
Antonella Frattari, Ennio Polilli, Vanessa Primiterra, Vincenzo Savini, Tamara Ursini, Giancarlo Di Iorio, Giustino Parruti
A better knowledge of factors predicting the development of sepsis in patients hospitalized in intensive care unit (ICU) might help deploy more targeted preventive and therapeutic strategies. In addition to the known clinical and demographic predictors of septic syndromes, in this study, we investigated whether measuring T and B lymphocyte subsets upon admission in the ICU may help individualize the prediction of ensuing sepsis during ICU stay. Between May 2015 and December 2016, we performed a prospective cohort study evaluating peripheral blood lymphocyte T-CD4+ (T-helper cells), T-CD8+ (cytotoxic T-cells), T-CD56 + (natural killer cells), and T-CD19+ (B-lymphocytes), using flow cytometry on blood samples collected 2 days after admission in the ICU...
January 2018: International Journal of Immunopathology and Pharmacology
Yanxia Huang, Jing Zhang, Ge Wang, Xiaoyu Chen, Rui Zhang, Hui Liu, Jinshui Zhu
Oxymatrine (OMT) as a type of alkaloids collected from Sophora flavescens Ait exerts some biological functions including anticancer properties. Here, we investigated the therapeutic effects of OMT in gastric cancer cells (HGC 27 and AGS). As a result, the exposure of gastric cancer (GC) cells to OMT contributed to the suppression of cell proliferation and invasion. Interleukin 21 receptor (IL-21R) was identified to be differentially expressed between OMT treatment group (4 mg/mL) and control group (0 mg/mL), and knockdown of IL-21R repressed cell proliferation and invasion via inactivation of the JAK2/STAT3 pathway...
January 2018: International Journal of Immunopathology and Pharmacology
Ju-Yang Jung, Bunsoon Choi, Hasan Md Sayeed, Chang-Hee Suh, Ye Won Kim, Hyoun-Ah Kim, Seonghyang Sohn
We examined the expression of human leukocyte antigen (HLA) and composition of differentiated T cells in the peripheral blood to understand the characteristics of the immune changes in patients with adult-onset Still's disease (AOSD). This study enrolled patients with AOSD (n = 14), patients with rheumatoid arthritis (RA, n = 20), and healthy controls (HC, n = 20). The percentage of surface-stained cells with HLA-DP, DQ, and DR alleles and the composition of differentiated T cells in peripheral blood leukocytes (PBLs) were evaluated by flow cytometry...
January 2018: International Journal of Immunopathology and Pharmacology
Xiao-Yu Chen, Jing Zhang, Li-Dan Hou, Rui Zhang, Wei Chen, Hui-Ning Fan, Yan-Xia Huang, Hui Liu, Jin-Shui Zhu
Targeting of the programmed cell-death 1 ligand 1 (PD-L1) signal pathway is a promising treatment strategy in several cancers. The purpose of this study was to evaluate the clinical significance of PD-L1 in patients with colon adenocarcinoma (COAD). A total of 240 patients who were diagnosed with COAD from The Cancer Genome Atlas (TCGA) RNA-sequencing data and another cohort for pair-matched COAD samples (n = 40) in tissue microarray (TMA) were enrolled in this study. The correlation of PD-L1 or miR-191-5p expression with clinicopathological features and prognosis in patients with COAD was further analyzed using TCGA data and TMA...
January 2018: International Journal of Immunopathology and Pharmacology
(no author information available yet)
International Journal of Immunopathology and Pharmacology 2018; 32, 1-15 Michał Ciebiera, Marta Włodarczyk, Małgorzata Wrzosek, Cezary Wojtyła, Błażej Męczekalski, Grażyna Nowicka, Krzysztof Łukaszuk and Grzegorz Jakiel TNF-α serum levels are elevated in women with clinically symptomatic uterine fibroids 10.1177/2058738418779461 The original version of this article contained an error in the author name Błażej Męczekalski which was incorrectly given as Męczekalski Błażej. This has now been corrected...
January 2018: International Journal of Immunopathology and Pharmacology
Narcy Arizmendi, Chenjie Hou, Fujiang Guo, Yiming Li, Marianna Kulka
Dendritic cell (DC) activation induces expression of co-stimulatory surface molecules, as well as migration into secondary lymphoid organs, where they activate naïve T-cells. A family of plant derivatives, eremophilane-type petasite sesquiterpenes, can regulate the immune system through DC targeting due to their anti-inflammatory effects. Peroxisome proliferator-activated receptor gamma (PPARγ) is involved in inhibition of inflammatory responses and induction of DCs to acquire a mucosal phenotype. Since mucosal DCs are central in innate immune responses, we hypothesized that eremophilane-type petasite sesquiterpenes exerted their anti-inflammatory effects by inhibiting DC maturation and activation through PPARγ...
January 2018: International Journal of Immunopathology and Pharmacology
Shinnosuke Morikawa, Naoe Kaneko, Chikara Okumura, Haruka Taguchi, Mie Kurata, Toshihiro Yamamoto, Haruhiko Osawa, Ayaka Nakanishi, Tamotsu Zako, Junya Masumoto
Recent findings revealed that type 2 diabetes mellitus (T2D) is a chronic inflammatory disease and an islet amyloid polypeptide (IAPP)/amylin, is deposited within pancreatic islets. IAPP/amylin has been reported to activate NACHT, LRR, and PYD domains-containing protein 3 (NLRP3) inflammasome in infiltrated macrophages. NLRP3, an intracellular pattern recognition receptor, has been shown to recognize pathogens and/or metabolites and complexes with the adopter protein apoptosis-associated speck-like protein containing a caspase-recruitment domain ASC to form a huge complex, called an inflammasome, an interleukin (IL)-1β-processing platform...
January 2018: International Journal of Immunopathology and Pharmacology
Rui-Da Xu, Fan Feng, Xiao-Sheng Yu, Zu-De Liu, Li-Feng Lao
MicroRNAs (miRNAs) as small non-coding RNAs act as either tumor suppressors or oncogenes in human cancers, of which miR-149-5p (miR-149) is involved in tumor growth and metastasis, but its role and molecular mechanisms underlying osteosarcoma growth are poorly understood. The correlation of miR-149 expression with clinicopathological characteristics and prognosis in patients with sarcoma was analyzed by The Cancer Genome Atlas (TCGA) RNA-sequencing data. Osteosarcoma cell growth affected by miR-149 was evaluated by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) and colony formation assays...
January 2018: International Journal of Immunopathology and Pharmacology
Mohamed A Hamzawy, Yasmin B El-Ghandour, Sekena H Abdel-Aziem, Zoba H Ali
The aspect of treatment of autistic behaviour was investigated using valproic acid rat model of pregnant female rats. Two main groups (10 male rats/group) were treated for 6 days and then divided into six subgroups. The first group of normal rats was divided into three subgroups: (A) - control group, (B) - treated with camel milk (CAM; 2 mL/p.o) and (C) - treated with leptin (1000 µg/kg i.p) twice daily. The second group of autistic rats was randomly distributed into four subgroups as follows: (D) - positive control (autistics rats), (E) - treated with CAM, (F) - treated with a moderate dose of leptin and (G) - treated with a higher dose of leptin...
January 2018: International Journal of Immunopathology and Pharmacology
Shanyue Sun, Guangying Du, Jiang Xue, Jinbo Ma, Minmin Ge, Hongbo Wang, Jingwei Tian
Indoleamine 2,3-dioxygenase (IDO), which is highly expressed in human glioblastoma and involved in tumor immune escape and resistance to chemotherapy, is clinically correlated with tumor progression and poor clinical outcomes, and is a promising therapeutic target for glioblastoma. IDO inhibitors are marginally efficacious as single-agents; therefore, combination with other therapies holds promise for cancer therapy. The aim of this study was to investigate the anti-tumor effects and mechanisms of the IDO inhibitor PCC0208009 in combination with temozolomide...
January 2018: International Journal of Immunopathology and Pharmacology
Alexander Autenshlyus, Sergey Arkhipov, Elena Mikhailova, Valentina Arkhipova, Nikolay Varaksin
Currently, the role of cytokines in the tumor progression, including breast cancer, is universally recognized. At the same time, there are still many questions concerning the role of individual cytokines and receptors for cytokines in various morphogenetic processes underlying the tumor progression. The objective of this work was to study cytokine production and vascular endothelial growth factor (VEGF)-R2 and VEGF-R1 expression by mammary adenocarcinoma (MAC) and the correlations with histopathological parameters of malignant tumors...
January 2018: International Journal of Immunopathology and Pharmacology
Chun-Mei Wang, Chun-Qing Yang, Bao-Hua Cheng, Jing Chen, Bo Bai
Orexin-A elicits multiple potent effects on a variety of tumor cells via different signaling pathways. However, it is unknown whether it has a neuroprotective effect on SH-SY5Y human neuroblastoma cells. This study investigated the neuroprotective effect of Orexin-A against hydrogen peroxide (H2 O2 )-induced oxidative damage in SH-SY5Y cells and the underlying mechanism. H2 O2 treatment decreased the viability of SH-SY5Y cells, induced apoptosis, and decreased superoxide dismutase activity. Orexin-A attenuated these effects, indicating that it protects SH-SY5Y cells against H2 O2 -induced oxidative damage...
January 2018: International Journal of Immunopathology and Pharmacology
Neslihan Edeer Karaca, Ezgi Ulusoy Severcan, Burcu Guven Bilgin, Elif Azarsiz, Sanem Akarcan, Nursen Cigerci Gunaydın, Nesrin Gulez, Ferah Genel, Guzide Aksu, Necil Kutukculer
Common variable immunodeficiency (CVID) and immunoglobulin A deficiency (IgAD) are the most prevalent primary immunodeficiency disorders. High rates of familial inheritance have been described in CVID and IgAD, but it is unknown in different ethnic populations. We aimed to determine the prevalence of familial cases and whether they showed more severe clinical characteristics than sporadic ones in Turkish patients. A total of 40 CVID and 70 IgAD patients and their 251 first-degree relatives (FDRs) were evaluated...
January 2018: International Journal of Immunopathology and Pharmacology
Alicja Kasperska-Zając, Aleksandra Damasiewicz-Bodzek, Ryszard Grzanka, Agnieszka Skrzypulec-Frankel, Katarzyna Bieniek, Agnieszka Sikora-Żydek, Jerzy Jochem
LIGHT (homologous to lymphotoxins, exhibiting inducible expression, and competing with herpes simplex virus (HSV) glycoprotein D for herpes virus entry mediator (HVEM), a receptor expressed by T lymphocytes) has been involved in various autoimmune and inflammatory disorders. LIGHT induces the expression of interleukin-8 (IL-8), which is up-regulated in chronic spontaneous urticaria (CSU). To determine circulating soluble LIGHT concentration and its relationship with IL-8 concentration in patients with CSU. Concentrations of LIGHT, IL-8, and C-reactive protein (CRP) were determined in plasma or serum of CSU patients by an enzyme-linked immunosorbent assay...
January 2018: International Journal of Immunopathology and Pharmacology
Yingjie Han, Frank Y Ma, Julie Di Paolo, David J Nikolic-Paterson
Non-selective inhibitors of spleen tyrosine kinase (SYK) efficiently suppress disease in T cell-dependent models of crescentic glomerulonephritis. However, the therapeutic potential of selective SYK inhibitors in this disease has not been established. In addition, we lack knowledge regarding SYK expression in non-myeloid cells in glomerulonephritis. We addressed these two issues in a rat model of nephrotoxic serum nephritis (NTN) using a SYK inhibitor, GS-492429. Disease was induced in Sprague-Dawley rats (Study 1) or Wistar-Kyoto (WKY) rats (Study 2) by immunization with sheep IgG and administration of sheep anti-rat nephrotoxic serum...
January 2018: International Journal of Immunopathology and Pharmacology
Enzo Palese, Maurizio Nudo, Grazia Zino, Valeria Devirgiliis, Mattia Carbotti, Eleonora Cinelli, Donatella Maria Rodio, Alessia Bressan, Carla Prezioso, Cecilia Ambrosi, Daniela Scribano, Valeria Pietropaolo, Daniela Fioriti, Vincenzo Panasiti
Candidiasis is a fungal infection caused by yeasts that belong to the genus Candida. There are over 20 species of Candida yeasts that can cause infection in humans, the most common of which is Candida albicans. Candida yeasts normally reside in the intestinal tract and can be found on mucous membranes and skin without causing infection. However, under immunocompromised conditions, Candida can cause significant infections in susceptible patients. Herein, we report a peculiar presentation of a C. albicans cutaneous infection in an immunocompetent young subject...
January 2018: International Journal of Immunopathology and Pharmacology
Xiumei Chen, Yongfeng Lai, Xicheng Song, Jinying Wu, Li Wang, Hua Zhang, Zhonglu Liu, Yan Wang
Chronic pharyngitis is characterized as a common inflammation of the pharyngeal mucosa, and anti-inflammatory medications are the common treatment to relieve it. Polysacharides of Citrus grandis L. Osbeck (PCG) and luteolin have been reported to have anti-inflammatory activities. In this study, the protective effects of PCG and luteolin on chronic pharyngitis are evaluated and the underlying mechanisms are explored. PCG and luteolin are administrated to animal models with granuloma, ear edema and chronic pharyngitis and the effects of PCG and luteolin on disease severity are evaluated...
January 2018: International Journal of Immunopathology and Pharmacology
Claudio Tana, Cosima Schiavone, Andrea Ticinesi, Fulvio Lauretani, Antonio Nouvenne, Christoph Frank Dietrich, Tiziana Meschi
Ultrasound (US) can reveal the presence of steatosis in non-alcoholic fatty liver disease (NAFLD), but its diagnostic accuracy to reveal signs of fibrosis is low except in advanced stages of disease (e.g. cirrhosis). Current guidelines suggest the use of clinical algorithms, such as the NAFLD fibrosis score, and elastography to predict the progression of fibrosis, and the integration of elastography improves the detection accuracy of liver stiffness. However, there is a lack of evidence about the correlation between clinical algorithms and conventional US, and elastography is limited by the relative low diffusion, necessity of training, and loss of diagnostic accuracy in patients with high body mass index (BMI), waist circumference, or increased thickness of parietal walls, with consequent significant rates of failure of measurement of liver stiffness...
January 2018: International Journal of Immunopathology and Pharmacology
Jin-Sil Park, Sung-Min Kim, Sun-Hee Hwang, Si-Young Choi, Ji Ye Kwon, Seung-Ki Kwok, Mi-La Cho, Sung-Hwan Park
Systemic lupus erythematosus (SLE; lupus) is a prototypical autoimmune disease characterized by circulating autoantibodies to nuclear antigens and immune complex deposition, resulting in damage to target organs. To investigate the effects of tacrolimus (TAC) on effector T cells and B cells, we examined its involvement in the development of effector T cells, germinal center (GC) B cells, and plasma cells in an in vitro system using wild-type (WT) and lupus-prone mice. The population of T helper (Th) 1, Th2, and Th17 cells interleukin (IL)-17-producing T (Th17) cells and the production of interferon-γ and interleukin-17A IL-17A were suppressed by TAC...
January 2018: International Journal of Immunopathology and Pharmacology
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