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International Journal of Immunopathology and Pharmacology

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https://www.readbyqxmd.com/read/27927705/shift-from-intravenous-or-16-subcutaneous-replacement-therapy-to-20-subcutaneous-immunoglobulin-in-patients-with-primary-antibody-deficiencies
#1
LETTER
Clementina Canessa, Jessica Iacopelli, Antonio Pecoraro, Giuseppe Spadaro, Andrea Matucci, Cinzia Milito, Alessandra Vultaggio, Carlo Agostini, Francesco Cinetto, Maria Giovanna Danieli, Simona Gambini, Carolina Marasco, Antonino Trizzino, Angelo Vacca, Domenico De Mattia, Baldassarre Martire, Alessandro Plebani, Mario Di Gioacchino, Alessia Gatta, Andrea Finocchi, Francesco Licciardi, Silvana Martino, Marco De Carli, Viviana Moschese, Chiara Azzari
In patients with primary antibody deficiencies, subcutaneous administration of IgG (SCIG) replacement is effective, safe, well-tolerated, and can be self-administered at home. A new SCIG replacement at 20% concentration (Hizentra(®)) has been developed and has replaced Vivaglobin(®) (SCIG 16%).An observational prospective multi-centric open-label study, with retrospective comparison was conducted in 15 Italian centers, in order to investigate whether and to what extent switching to Hizentra(®) would affect frequency of infusions, number of infusion sites, patients' satisfaction, and tolerability in patients previously treated with Vivaglobin(®) or intravenous immunoglobulins (IVIG)...
December 7, 2016: International Journal of Immunopathology and Pharmacology
https://www.readbyqxmd.com/read/27903846/cytokine-profiles-of-tumor-supernatants-in-invasive-ductal-cancer-and-fibroadenoma-of-the-breast-and-its-relationship-with-vegf-a-expression-in-the-tumors
#2
Alexander I Autenshlyus, Sergey A Arkhipov, Tatiana A Kunts, Igor O Marinkin, Elena S Mikhailova, Xenia V Karpukhina, Nikolay A Varaksin
Interrelations between cytokines, produced by invasive ductal carcinoma (IDC) and fibroadenoma (FA) of the breast, and angiogenic growth factor VEGF-A, expressed in IDC and FA, were investigated. The analysis of the cytokine profiles of IDC and FA was performed by cultivation of tumor biopsy specimens in vitro. Testing of the cytokine-producing reserve of the tumors for production of VEGF-A was conducted by culturing samples of IDC and FA in a medium containing polyclonal activator (a complex of phytohemagglutinin, concanavalin A, and lipopolysaccharide)...
November 30, 2016: International Journal of Immunopathology and Pharmacology
https://www.readbyqxmd.com/read/27903845/protein-biomarkers-of-mood-disorders
#3
EDITORIAL
Carmen Rodríguez Cerdeira, Elena Sánchez-Blanco, Beatriz Sánchez-Blanco, Jose Luis González-Cespón
Psychiatric evaluation presents a significant challenge because it conceptually integrates the input from multiple psychopathological approaches. Recent technological advances in the study of protein structure, function, and interactions have provided a breakthrough in the diagnosis and treatment of mood disorders (MD), and have identified novel biomarkers to be used as indicators of normal and disease states or response to drug treatment. The investigation of biomarkers for psychiatric disorders, such as enzymes (catechol-O-methyl transferase and monoamine oxidases) or neurotransmitters (dopamine, serotonin, norepinephrine) and their receptors, particularly their involvement in neuroendocrine activity, brain structure, and function, and response to psychotropic drugs, should facilitate the diagnosis of MD...
November 30, 2016: International Journal of Immunopathology and Pharmacology
https://www.readbyqxmd.com/read/27903844/therapeutic-approaches-to-pediatric-pseudotumor-cerebri-new-insights-from-literature-data
#4
Giovanna Vitaliti, Piero Pavone, Nassim Matin, Omidreza Tabatabaie, Salvatore Cocuzza, Michele Vecchio, Luigi Maiolino, Paola Di Mauro, Angelo Conti, Riccardo Lubrano, Agostino Serra, Raffaele Falsaperla
The pseudotumor cerebri syndrome (PTCS), also known as idiopathic intracranial hypertension (IIH), is characterized by signs and symptoms of increased intracranial pressure such as headache and cranial nerve palsies, in the absence of any space-occupying mass. This condition commonly affects overweight women of childbearing age, even if it is also frequent in men and children. Children with PTCS may present with atypical signs and symptoms, with a different prognosis compared to adults. However, the treatment is the same for both children and adults, even if there are no strict treatment guidelines in regards...
November 30, 2016: International Journal of Immunopathology and Pharmacology
https://www.readbyqxmd.com/read/27903843/downregulation-of-l-arginine-metabolism-in-dendritic-cells-induces-tolerance-to-exogenous-antigen
#5
Patricia U Simioni, Luis Gr Fernandes, Wirla Msc Tamashiro
Dendritic cells (DC) are potential tools for therapeutic applications and several strategies to generate tolerogenic DCs are under investigation. When activated by cytokines and microbial products, DCs express mediators that modulate immune responses. In this regard, the metabolites generated by the activities of inducible nitric oxide synthase (iNOS) and arginase in DCs seem to play important roles. Here, we evaluated the effects of adoptive transfer of DCs generated in vitro from bone marrow precursors (BMDC) modulated with L-NAME (Nω-nitro-L-arginine methyl ester) and NOHA (NG-Hydroxy-L-arginine), inhibitors of iNOS and arginase, respectively, upon the immune response of the wild type (BALB/c) and OVA-TCR transgenic (DO11...
November 30, 2016: International Journal of Immunopathology and Pharmacology
https://www.readbyqxmd.com/read/27799299/arabinoxylan-rice-bran-biobran-suppresses-the-viremia-level-in-patients-with-chronic-hcv-infection-a-randomized-trial
#6
Hosny Salama, Eman Medhat, Magda Shaheen, Abdel-Rahman N Zekri, Tarneem Darwish, Mamdooh Ghoneum
Current treatments for Hepatitis C virus (HCV) have severe side effects and are very expensive. There is a need to explore effective natural therapies against HCV that are less toxic and more cost-effective. In the current study, 37 chronic HCV patients were randomized into two groups and treated with either pegylated interferon (PEG IFN) plus ribavirin (n = 21) or Biobran, an arabinoxylan from rice bran (1 g/day) (n = 16). We examined viremia, liver enzymes, interferon-γ (IFN-γ) levels in serum, and toxicity before and three months after treatment...
October 31, 2016: International Journal of Immunopathology and Pharmacology
https://www.readbyqxmd.com/read/27770044/methotrexate-impact-on-radiographic-progression-in-biologic-treated-rheumatoid-arthritis-under-clinical-remission-a-case-report-on-monozygotic-caucasian-twins
#7
Tomas Soukup, Jana Nekvindova, Martin Dosedel, Jindra Brtkova, Jan Toms, Drahomira Bastecka, Petr Bradna, Jiri Vlcek, Petr Pavek
We describe Caucasian monozygotic twin brothers with rheumatoid arthritis (RA) and discuss influence of predictors to methotrexate (MTX) outcome treatment. Single nucleotide polymorphisms (SNPs) of the MTX metabolic pathways were genotyped. Twins have multiple mutations: a CC mutation of SNP 1298A>C in methylenetetrahydrofolate reductase (MTHFR) gene, CC mutations of three SNPs in the adenosine receptor gene ADORA2A (rs3761422_4217241T>C, rs2267076_4221164T>C, rs2236624_4226593T>C), and a heterozygous genotype in SNPs ATIC_rs2372536_347C>G, MTHFD1_rs2236225_1958G>A...
October 21, 2016: International Journal of Immunopathology and Pharmacology
https://www.readbyqxmd.com/read/27760847/levels-of-circulating-soluble-receptor-activator-of-nf-%C3%AE%C2%BAb-and-interleukins-1-predicting-outcome-of-locally-advanced-basal-cell-carcinoma
#8
Quan Lin, Yan Li, Duo Zhang, Hongjuan Jin
Decreasing levels of cytokines are associated with better responses to therapies, while increasing levels are related to progression or recurrence and decreased survival. NF-κB's role in the cell cycle and its ubiquity are only stressed out by the evidence for the importance of activation (aberrant activation in the majority of cancers) of both canonical and non-canonical pathways in advanced basal cell carcinomas (aBCCs), a subset of basal cell carcinoma (BCC). NF-κB acts through its canonical, or classical, form activated by interleukin-1 (IL-1), regulates cytoprotective, innate, and adaptive immune responses...
October 19, 2016: International Journal of Immunopathology and Pharmacology
https://www.readbyqxmd.com/read/27760846/t-tn-immunotherapy-avoiding-immune-deviation
#9
Hye-Youn Son, Vasso Apostolopoulos, Chul-Woo Kim
Tumor immunotherapy, capable of inducing both cellular and humoral immune responses, is an attractive treatment strategy for cancer. It has been reported that the inactivation of cell-mediated immunity by hyper-activation of humoral immunity-referred to as immune deviation-does not inhibit tumor growth. We investigated the ability of several adjuvants to elicit Thomsen-Friedenreich (T/Tn)-specific humoral immunity while avoiding immune deviation and conferring protection against tumorigenesis. T/Tn (9:1) antigen was purified from blood type O erythrocytes donated by healthy Korean volunteers...
October 19, 2016: International Journal of Immunopathology and Pharmacology
https://www.readbyqxmd.com/read/27742881/the-effect-of-dichloroacetate-on-male-rat-thymus-and-on-thymocyte-cell-cycle
#10
Jurate Stanevičiūtė, Daiva Urbonienė, Angelija Valančiūtė, Ingrida Balnytė, Astra Vitkauskienė, Brigita Grigalevičienė, Donatas Stakišaitis
The study aim was to investigate the effect of dichloroacetate (DCA) on thymus and the thymocyte cycle in rats. Wistar male gonad-intact and castrated rats (4-5 weeks) were investigated in the following groups: (1) control; (2) treated with DCA; and (3) treated with the DCA and sodium valproate (NaVP) combination. Rats were treated for 4 weeks with DCA 200 mg/kg/day alone and 300 mg/kg/day of NaVP plus 200 mg/kg/day of DCA (every second week, beginning with NaVP). After the experiment, the thymus was weighted, and the thymus lobe was taken for thymocyte flow cytometry...
October 14, 2016: International Journal of Immunopathology and Pharmacology
https://www.readbyqxmd.com/read/27707958/a-concise-review-on-advances-in-development-of-small-molecule-anti-inflammatory-therapeutics-emphasising-ampk-an-emerging-target
#11
Chethan Gejjalagere Honnappa, Unnikrishnan Mazhuvancherry Kesavan
Inflammatory diseases are complex, multi-factorial outcomes of evolutionarily conserved tissue repair processes. For decades, non-steroidal anti-inflammatory drugs and cyclooxygenase inhibitors, the primary drugs of choice for the management of inflammatory diseases, addressed individual targets in the arachidonic acid pathway. Unsatisfactory safety and efficacy profiles of the above have necessitated the development of multi-target agents to treat complex inflammatory diseases. Current anti-inflammatory therapies still fall short of clinical needs and the clinical trial results of multi-target therapeutics are anticipated...
October 5, 2016: International Journal of Immunopathology and Pharmacology
https://www.readbyqxmd.com/read/27707957/preliminary-study-on-emodin-alleviating-alpha-naphthylisothiocyanate-induced-intrahepatic-cholestasis-by-regulation-of-liver-farnesoid-x-receptor-pathway
#12
Yan Ding, Xiao-Li Xiong, Li-Shan Zhou, Su-Qi Yan, Huan Qin, Hua-Rong Li, Ling-Ling Zhang, Peng Chen, Cong Yao, Zhi-Xia Jiang, Lei Zhao
The aim of this study is to investigate Emodin on alleviating intrahepatic cholestasis by regulation of liver farnesoid X receptor (FXR) pathway. Cell and animal models of intrahepatic cholestatis were established. Biochemical tests and histomorphology were performed. The messenger RNA (mRNA) and protein expression of FXR, small heterodimer partner (SHP), uridine diphosphate glucuronosyltransferase 2 family polypeptide B4 (UGT2B4), and bile salt export pump (BSEP) was detected. As a result, compared with the model group, the serum levels of biochemical test were significantly lower in the Emodin group (P <0...
October 5, 2016: International Journal of Immunopathology and Pharmacology
https://www.readbyqxmd.com/read/27694615/camel-whey-protein-improves-lymphocyte-function-and-protects-against-diabetes-in-the-offspring-of-diabetic-mouse-dams
#13
Mohamed H Mahmoud, Gamal Badr, Nashwa A El Shinnawy
The prevalence of health problems in the offspring of pregnant diabetic mothers has recently been verified. Therefore, the present study was designed to investigate the influence of dietary camel whey protein (CWP), administered as a supplement to streptozotocin (STZ)-induced diabetic pregnant mice, on the efficiency of the immune system of the offspring. Three groups of female mice (n = 10) were used: non-diabetic control mice, diabetic mice, and diabetic mice orally administered CWP during the pregnancy and lactation periods...
September 30, 2016: International Journal of Immunopathology and Pharmacology
https://www.readbyqxmd.com/read/27694614/critical-evaluation-of-challenges-and-future-use-of-animals-in-experimentation-for-biomedical-research
#14
Vijay Pal Singh, Kunal Pratap, Juhi Sinha, Koundinya Desiraju, Devika Bahal, Ritushree Kukreti
Animal experiments that are conducted worldwide contribute to significant findings and breakthroughs in the understanding of the underlying mechanisms of various diseases, bringing up appropriate clinical interventions. However, their predictive value is often low, leading to translational failure. Problems like translational failure of animal studies and poorly designed animal experiments lead to loss of animal lives and less translatable data which affect research outcomes ethically and economically. Due to increasing complexities in animal usage with changes in public perception and stringent guidelines, it is becoming difficult to use animals for conducting studies...
September 30, 2016: International Journal of Immunopathology and Pharmacology
https://www.readbyqxmd.com/read/27694613/effects-of-tranexamic-acid-on-coagulation-indexes-of-patients-undergoing-heart-valve-replacement-surgery-under-cardiopulmonary-bypass
#15
Fei Liu, Dong Xu, Kefeng Zhang, Jian Zhang
This study aims to explore the effects of tranexamic acid on the coagulation indexes of patients undergoing heart valve replacement surgery under the condition of cardiopulmonary bypass (CPB). One hundred patients who conformed to the inclusive criteria were selected and divided into a tranexamic acid group and a non-tranexamic acid group. They all underwent heart valve replacement surgery under CPB. Patients in the tranexamic acid group were intravenously injected with 1 g of tranexamic acid (100 mL) at the time point after anesthesia induction and before skin incision and at the time point after the neutralization of heparin...
September 30, 2016: International Journal of Immunopathology and Pharmacology
https://www.readbyqxmd.com/read/27694612/establishing-the-colitis-associated-cancer-progression-mouse-models
#16
Haiming Zheng, Zhanjun Lu, Ruhua Wang, Niwei Chen, Ping Zheng
Inflammatory bowel disease (IBD) has been reported as an important inducer of colorectal cancer (CRC). The most malignant IBD-associated CRC type has been highlighted as colitis-associated cancer (CAC). However, lack of CAC cases and difficulties of the long follow-up research have challenged researchers in molecular mechanism probing. Here, we established pre-CAC mouse models (dextran sulfate sodium [DSS] group and azoxymethane [AOM] group) and CAC mouse model (DSS/AOM group) to mimic human CAC development through singly or combinational treatment with DSS and AOM followed by disease activity index analysis...
September 30, 2016: International Journal of Immunopathology and Pharmacology
https://www.readbyqxmd.com/read/27679679/omalizumab-a-useful-tool-for-inducing-tolerance-to-bee-venom-immunotherapy
#17
L Ricciardi
No abstract text is available yet for this article.
September 27, 2016: International Journal of Immunopathology and Pharmacology
https://www.readbyqxmd.com/read/27647464/treatment-related-myelodysplastic-syndrome-t-mds-acute-myeloid-leukemia-aml-in-children-with-cancer-a-single-center-experience
#18
Athanasios Tragiannidis, Nikolaos Gombakis, Maria Papageorgiou, Emmanuel Hatzipantelis, Theodotis Papageorgiou, Maria Hatzistilianou
Treatment-related myelodysplastic syndrome (t-MDS)/acute myeloid leukemia (AML) is a devastating early or late complication of treatment for childhood cancer related with a significant morbidity and mortality. We retrospectively studied survivors of childhood cancer. Overall, 287 patients were recorded in the databases and we identified three (1.04%) with t-MDS. The primary cancer diagnoses were Langerhans cell histiocytosis (one patient) and acute lymphoblastic leukemia (ALL; two patients). The mean age of patients was 12...
September 19, 2016: International Journal of Immunopathology and Pharmacology
https://www.readbyqxmd.com/read/27895288/some-biological-activities-of-pigments-extracted-from-micrococcus-roseus-ptcc-1411-and-rhodotorula-glutinis-ptcc-5257
#19
Hossein Rostami, Hassan Hamedi, Mahmoud Yolmeh
The importance of replacing synthetic pigments with natural types is increasing day by day in the food industry due to the harmful effects of some synthetic pigments. Microorganisms are a major source of natural pigments, which nowadays have attracted the attention of researchers. In this study, carotenoid pigments were produced by Micrococcus roseus and Rhodotorula glutinis, and some of their biological properties such as antimicrobial, antioxidant, anticancer, and anti-inflammatory activities were evaluated...
December 2016: International Journal of Immunopathology and Pharmacology
https://www.readbyqxmd.com/read/27895287/sudden-sensorineural-hearing-loss-is-there-a-connection-with-inner-ear-electrolytic-disorders-a-literature-review
#20
EDITORIAL
Andrea Ciorba, Virginia Corazzi, Chiara Bianchini, Claudia Aimoni, Henryk Skarzynski, Piotr Henryk Skarzynski, Stavros Hatzopoulos
Electrolytic disorders of the inner ear represent a model that could be implicated in partially explaining the pathogenesis of sudden sensorineural hearing loss (SSNHL). Different types of electrolytes and different inner-ear loci are involved in cochlear homeostasis physiologically, to ensure the maintenance of an ion-balanced cochlear environment allowing a normal hair cell function. It has been hypothesized that a sudden loss of endocochlear potential, due to a rapid disruption of the inner ear fluid osmolality, could be responsible for a deterioration of the hearing function caused by damaged hair cells...
December 2016: International Journal of Immunopathology and Pharmacology
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