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Biomedical and Environmental Sciences: BES

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https://www.readbyqxmd.com/read/29773097/polymorphism-in-rs2229783-of-the-alpha-1-xi-collagen-gene-is-associated-with-susceptibility-to-but-not-severity-of-kashin-beck-disease-in-a-northwest-chinese-han-population
#1
Xiao Wei Shi, Feng Zhang, Zhi Yan Li, Ai Li Lyu, Xiong Guo
A case-control study was conducted to investigate associations between organophosphate pesticide (OP) exposure, aggression, impulsivity, and attempted suicide. The purpose of this study was to explore whether genomic polymorphisms in the alpha 1(XI) collagen gene (COL11A1) were associated with the risk and severity of Kashin-Beck disease (KBD). Twenty-two single nucleotide polymorphisms (SNPs) in COL11A1 were genotyped in 274 KBD cases and 249 healthy controls using the Sequenom MassARRAY system. The expression of type XI collagen (COL11A) in the knee articular cartilage of 22 KBD patients and 21 controls was analyzed by immunohistochemistry...
April 2018: Biomedical and Environmental Sciences: BES
https://www.readbyqxmd.com/read/29773096/acceptance-of-chemo-prophylaxis-for-latent-tuberculosis-infection-among-high-school-college-student-contacts-of-tuberculosis-patients-in-shanghai-china
#2
Yang Li, Yi Hui Zheng, Li Ping Lu, Mei Xia Yang, Chang Ming Zhou, Zheng An Yuan, Yi Hu, Biao Xu
Student contacts of tuberculosis (TB) cases are susceptible to latent tuberculosis infection (LTBI), and chemo-prophylaxis can reduce the risk of active TB among them. This study aimed to assess the acceptance of chemo-prophylaxis for LTBI among students, and their concerns regarding TB and its preventive treatment. A total of 560 students contacts were included in the investigation. The extent of contact was categorized from high to low (4 levels) with 12.9% of the students being close contacts. About 87.0% of the students were willing to receive chemo-prophylaxis if diagnosed with, LTBI, whereas 73 students declined...
April 2018: Biomedical and Environmental Sciences: BES
https://www.readbyqxmd.com/read/29773095/the-role-of-fibrocyte-in-the-pathogenesis-of-silicosis
#3
Juan Li, Wu Yao, Jian Yong Hou, Lin Zhang, Lei Bao, Hui Ting Chen, Di Wang, Zhong Zheng Yue, Yi Ping Li, Miao Zhang, Xing Hao Yu, Jian Hui Zhang, Ya Qian Qu, Chang Fu Hao
Exposure to free silica induces silicosis and myofibroblasts are regarded as primary effector cells. Fibrocytes can differentiate into myofibroblast. Therefore, the present study was designed to investigate whether fibrocytes participate in silicosis. The rat model of silicosis was established. Hematoxylin-eosin stainings and Masson stainings were used to evaluate the histopathology and collagen deposition. Flow cytometry and immunofluorescence were performed to detect the number of fibrocytes and their contribution to myofibroblasts...
April 2018: Biomedical and Environmental Sciences: BES
https://www.readbyqxmd.com/read/29773094/replication-and-pathology-of-duck-influenza-virus-subtype-h9n2-in-chukar
#4
Yin Chuan Zhu, Bin Zhang, Zeng Hui Sun, Xi Jing Wang, Xiao Hui Fan, Ling Xi Gao, Ying Liang, Xiao Yan Chen, Zeng Feng Zhang
To investigate the susceptibility of Chukars to duck avian influenza virus H9N2 and explore their role in interspecies transmission of influenza viruses. Chukars were inoculated with duck avian influenza viruses H9N2. The present study demonstrated that inflammatory lesions and virus antigen were present in the trachea, bronchus, and parabronchus, and the viruses could be isolated from throat swabs and lung tissue homogenate supernatants. At 14 d post virus inoculation, anti-H9 influenza virus antibody in the serum was detected...
April 2018: Biomedical and Environmental Sciences: BES
https://www.readbyqxmd.com/read/29773093/combined-influence-of-insulin-resistance-and-inflammatory-biomarkers-on-type-2-diabetes-a-population-based-prospective-cohort-study-of-inner-mongolians-in-china
#5
Qiao Yan Qiu, Bei Lei Zhang, Ming Zhi Zhang, Jia Hui Wu, Jing Wen Zhou, Zhu Liang, Yong Hong Zhang, Shao Yan Zhang
This prospective study was designed to examine the combined influence of insulin resistance (IR) and inflammatory biomarker levels on type 2 diabetes mellitus (T2DM) among 1,903 Inner Mongolians. During follow-up, 205 (10.77%) participants developed T2DM, and the incidence of T2DM was higher among subjects with IR, elevated C-reactive protein (CRP), elevated sICAM-1, elevated sE-selectin, or the coexistences of IR with elevated CRP, elevated sICAM-1, elevated sE-selectin, and elevated angiotensin II (all P < 0...
April 2018: Biomedical and Environmental Sciences: BES
https://www.readbyqxmd.com/read/29773092/preliminary-study-on-drug-susceptibility-profile-and-resistance-mechanisms-to-macrolides-of-clinical-isolates-of-non-tuberculous-mycobacteria-from-china
#6
Fu Li, Gui Lian Li, Hui Pang, Hai Can Liu, Tong Yang Xiao, Shuang Jun Li, Qiao Luo, Yi Jiang, Rui Bai Wang, Kang Lin Wan
OBJECTIVE: Macrolide susceptibility and drug resistance mechanisms of clinical non-tuberculous mycobacteria (NTM) isolates were preliminarily investigated for more accurate diagnosis and treatment of the infection in China. METHODS: Four macrolides, including clarithromycin (CLAR), azithromycin (AZM), roxithromycin (ROX), and erythromycin (ERY), were used to test the drug susceptibility of 310 clinical NTM isolates from six provinces of China with the broth microdilution method...
April 2018: Biomedical and Environmental Sciences: BES
https://www.readbyqxmd.com/read/29773091/inactivated-sendai-virus-induces-ros-dependent-apoptosis-and-autophagy-in-human-prostate-cancer-cells
#7
Miao Qian, Hai Ming Tan, Ning Yu, Tao Wang, Quan Zhang
OBJECTIVE: The current study aims to investigate the effect of Hemagglutinating virus of Japan envelope (HVJ-E) on induction of apoptosis and autophagy in human prostate cancer PC3 cells, and the underlying mechanisms. METHODS: PC3 cells were treated with HVJ-E at various multiplicity of infection (MOI), and the generated reactive oxygen species (ROS), cell viability, apoptosis, and autophagy were detected, respectively. Next, the role of ROS played in the regulation of HVJ-E-induced apoptosis and autuphagy in PC3 cells were analysed...
April 2018: Biomedical and Environmental Sciences: BES
https://www.readbyqxmd.com/read/29773090/vsita-an-improved-approach-of-target-amplification-in-the-identification-of-viral-pathogens
#8
Yi Zhang, Chen Zhang, Bo Li, Yang Li, Xiao Zhou He, Acher Li, Wei Wu, Su Xia Duan, Fang Zhou Qiu, Ji Wang, Xin Xin Shen, Meng Jie Yang, De Xin Li, Xue Jun Ma
OBJECTIVE: Unbiased next generation sequencing (NGS) is susceptible to interference from host or environmental sequences. Consequently, background depletion and virome enrichment techniques are usually needed for clinical samples where viral load is much lower than background sequences. METHODS: A viral Sequence Independent Targeted Amplification (VSITA) approach using a set of non-ribosomal and virus-enriched octamers (V8) was developed and compared with traditionally used random hexamers (N6)...
April 2018: Biomedical and Environmental Sciences: BES
https://www.readbyqxmd.com/read/29773089/fat-to-muscle-ratio-a-new-anthropometric-indicator-for-predicting-metabolic-syndrome-in-the-han-and-bouyei-populations-from-guizhou-province-china
#9
Ke Xu, Hui Juan Zhu, Shi Chen, Lu Chen, Xin Wang, Li Yuan Zhang, Li Pan, Li Wang, Kui Feng, Ke Wang, Fen Dong, Ding Ming Wang, Yang Wen Yu, Hui Pan, Guang Liang Shan
OBJECTIVE: To investigate the prevalence and possible factors influencing metabolic syndrome in people from Guizhou Province and to explore the predictive value of the fat-to-muscle ratio in diagnosing metabolic syndrome. METHODS: A multistage stratified sampling method was used in this cross-sectional study of 20-80 years old Han and Bouyei populations from Guizhou Province, southwestern China, from October-December 2012. The study included 4,553 cases of metabolic syndrome, that was defined according to 2005 International Diabetes Federation criteria...
April 2018: Biomedical and Environmental Sciences: BES
https://www.readbyqxmd.com/read/29773088/lipoprotein-a-as-a-marker-for-predicting-the-presence-and-severity-of-coronary-artery-disease-in-untreated-chinese-patients-undergoing-coronary-angiography
#10
Di Sun, Xi Zhao, Sha Li, Yan Zhang, Na Qiong Wu, Cheng Gang Zhu, Yuan Lin Guo, Ying Gao, Ping Qing, Geng Liu, Qian Dong, Jian Jun Li
OBJECTIVE: Low-density lipoprotein cholesterol (LDL-C) has been well known as the risk factor of coronary artery disease (CAD). However, the role of lipoprotein (a) [Lp(a)] in the development of CAD is of great interest but still controversial. Thus, we aim to explore the effect of Lp(a) on predicting the presence and severity of CAD in Chinese untreated patients, especially in combination with LDL-C. METHODS: We consecutively recruited 1,980 non-treated patients undergoing coronary angiography, among which 1,162 patients were diagnosed with CAD...
April 2018: Biomedical and Environmental Sciences: BES
https://www.readbyqxmd.com/read/29673449/inhibition-of-erythroid-differentiation-of-human-leukemia-k562-cells-by-n-acetylcysteine-and-ascorbic-acid-through-downregulation-of-ros
#11
Chun Hong Yu, Liang Jiang, Ying Wang, Ning Xuan Cui, Xiao Zhao, Zong Chun Yi
This study investigated the effects of N-acetylcysteine (NAC) and ascorbic acid (AA) on hemin-induced K562 cell erythroid differentiation and the role of reactive oxygen species (ROS) in this process. Hemin increased ROS levels in a concentration-dependent manner, whereas NAC and AA had opposite effects. Both NAC and AA eliminated transient increased ROS levels after hemin treatment, inhibited hemin-induced hemoglobin synthesis, and decreased mRNA expression levels of β-globin, γ-globin, and GATA-1 genes significantly...
March 2018: Biomedical and Environmental Sciences: BES
https://www.readbyqxmd.com/read/29673448/case-control-study-of-impulsivity-aggression-pesticide-exposure-and-suicide-attempts-using-pesticides-among-farmers
#12
Chun Ping Lyu, Jian Ru Pei, L Cheryl Beseler, Yu Ling Li, Jian Hui Li, Ming Ren, Lorann Stallones, Shu Ping Ren
A case-control study was conducted to investigate associations between organophosphate pesticide (OP) exposure, aggression, impulsivity, and attempted suicide. Questionnaires were used to collect information; impulsivity and aggression were measured by the Barratt Impulsivity Scale (BIS) and the Aggression Inventory (AI). A greater number of OP symptoms was associated with an increased odds of a suicide attempt after adjusting for marital status and income (OR = 1.45; CI 1.14-1.86). Attempted suicide was significantly associated with high impulsivity scores (means: 72...
March 2018: Biomedical and Environmental Sciences: BES
https://www.readbyqxmd.com/read/29673447/the-taxonomic-status-of-spermophilus-in-the-plague-area-of-dingbian-county-shaanxi-province-china
#13
Cui Hong An, Bao Bao Chen, Suo Ping Fan, Yang Xin Sun, Wen Lyu, Jian Jun She
This study was conducted to define the taxonomic status of Spermophilus in the plague area of Dingbian County in Shaanxi Province, China, through the two-factor variance analysis of morphological characteristics, DNA barcoding, and chromosome karyotype analysis. The Spermophilus samples collected from Dingbian and Zhengxiang Baiqi Counties exhibited significant differences in their morphological measurements. All Spermophilus samples form two distinct branches in neighbor-joining (NJ) tree. One branch included the Spermophilus samples collected from Inner Mongolia, and the other branch included samples collected from the plague foci of Shaanxi Province and the Ningxia Region...
March 2018: Biomedical and Environmental Sciences: BES
https://www.readbyqxmd.com/read/29673446/a-cross-sectional-survey-assessing-carriage-of-streptococcus-pneumoniae-in-a-healthy-population-in-xinjiang-uygur-autonomous-region-of-china
#14
Na Xie, Zhao Yun Chen, Tao Chen, Bing Qing Zhu, Li Xu, Yuan Gao, Ai Yu Zhang, Pan Zhao, Ji Wen Liu, Zhu Jun Shao
The carriage rate and serotype distribution of Streptococcus pneumoniae (S. pneumoniae) in a healthy population in China remains unclear. In this study, we collected the oropharyngeal swabs from 513 individuals in Xinjiang, China. Real-time PCR targeting the lytA gene and 12 serotypes were assessed to identify S. pneumoniae carriage. The total carriage rate of S. pneumoniae was 70.4% (361/513). The most prevalent serotypes were 19B/F, 18B/C, 5, and 6A/B. The highest carriage rate of S. pneumoniae was noted in children aged 6-10 years (88...
March 2018: Biomedical and Environmental Sciences: BES
https://www.readbyqxmd.com/read/29673445/the-relationship-between-japanese-encephalitis-and-environmental-factors-in-china-explored-using-national-surveillance-data
#15
Xiao Xia Huang, Lei Yan, Xiao Yan Gao, Yu Huan Ren, Shi Hong Fu, Yu Xi Cao, Ying He, Wen Wen Lei, Guo Dong Liang, Shi Wen Wang, Huan Yu Wang
Japanese encephalitis (JE) is a serious public health issue. This study was undertaken to better understand the relationship between JE distribution and environmental factors in China. JE data from 2005 to 2010 were retrieved from National Notifiable Disease Report System. ArcGIS, remote sensing techniques, and R software was used to exhibit and explore the relationship between JE distribution and environmental factors. Our results indicated that JE cases were mostly concentrated in warm-temperate, semitropical and tropical zones with annual precipitation > 400 mm; Broad-leaved evergreen forest, shrubs, paddy field, irrigated land, dryland, evergreen coniferous forest, and shrubland were risk factors for JE occurrence, and the former five were risk factors for counties with high JE incidence...
March 2018: Biomedical and Environmental Sciences: BES
https://www.readbyqxmd.com/read/29673444/therapeutic-potential-of-anti-hiv-rna-loaded-exosomes
#16
REVIEW
Yong Qiu, Jing Ma, Yi Zeng
No abstract text is available yet for this article.
March 2018: Biomedical and Environmental Sciences: BES
https://www.readbyqxmd.com/read/29673443/taqman-real-time-rt-pcr-assay-for-detecting-and-differentiating-japanese-encephalitis-virus
#17
Nan Shao, Fan Li, Kai Nie, Shi Hong Fu, Wei Jia Zhang, Ying He, Wen Wen Lei, Qian Ying Wang, Guo Dong Liang, Yu Xi Cao, Huan Yu Wang
OBJECTIVE: To detect Japanese encephalitis virus (JEV) rapidly and distinguish its genotypes, a TaqMan-based reverse transcriptase quantitative polymerase chain reaction (RT-PCR) detection system was developed. METHODS: By aligning the full-length sequences of JEV (G1-G5), six sets of highly specific TaqMan real-time RT-PCR primers and probes were designed based on the highly conserved NS1, NS2, and M genes of JEV, which included one set for non-specific JEV detection and five sets for the detection of specific JEV genotypes...
March 2018: Biomedical and Environmental Sciences: BES
https://www.readbyqxmd.com/read/29673442/subchronic-oral-toxicity-of-silica-nanoparticles-and-silica-microparticles-in-rats
#18
Chun Lai Liang, Qian Xiang, Wen Ming Cui, Jin Fang, Na Na Sun, Xiao Peng Zhang, Yong Ning Li, Hui Yang, Zhou Yu, Xu Dong Jia
OBJECTIVE: To investigate the subchronic oral toxicity of silica nanoparticles (NPs) and silica microparticles (MPs) in rats and to compare the difference in toxicity between two particle sizes. METHODS: Sprague-Dawley rats were randomly divided into seven groups: the control group; the silica NPs low-, middle-, and high-dose groups; and the silica MPs low-, middle-, and high-dose groups [166.7, 500, and 1,500 mg/(kg•bw•day)]. All rats were gavaged daily for 90 days, and deionized water was administered to the control group...
March 2018: Biomedical and Environmental Sciences: BES
https://www.readbyqxmd.com/read/29673441/ywhaz-binds-to-trim21-but-is-not-involved-in-trim21-stimulated-osteosarcoma-cell-proliferation
#19
Qing Zhong Zeng, Wan Ting Liu, Jun Lei Lu, Xiao Hui Liu, Yun Fang Zhang, Lang Xia Liu, Xue Juan Gao
OBJECTIVE: Osteosarcoma is the most common type of malignant bone tumor in children and adolescents. The role of E3 ligases in tumorigenesis is currently a focus in tumor research. In the present study, we investigated the role of the E3 ligase tripartite motif 21 (TRIM21) in osteosarcoma cell proliferation. METHODS: 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) assays were used to assess osteosarcoma cell viability. U2-OS cells stably carrying a recombinant lentivirus expressing tetracycline-regulated TRIM21 were screened...
March 2018: Biomedical and Environmental Sciences: BES
https://www.readbyqxmd.com/read/29673440/mir-93-5p-transferred-by-exosomes-promotes-the-proliferation-of-esophageal-cancer-cells-via-intercellular-communication-by-targeting-pten
#20
Meng Xin Liu, Juan Liao, Ming Xie, Zhi Kui Gao, Xiang Hu Wang, Ying Zhang, Mu He Shang, Li Hong Yin, Yue Pu Pu, Ran Liu
OBJECTIVE: To investigate the relationship between plasma miR-93-5p and the risk of esophageal cancer, as well as the influence of miR-93-5p on the biological function of esophageal cancer cells, exerted through exosomes. METHODS: The expression of plasma miR-93-5p in esophageal cancer patients and healthy controls was analysed by real-time quantitative PCR. The influence of miR-93-5p on the risk and prognosis of esophageal carcinoma was analyzed by conditional logistic regression and survival analysis...
March 2018: Biomedical and Environmental Sciences: BES
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