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Biomedical and Environmental Sciences: BES

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https://www.readbyqxmd.com/read/28549496/mutual-impact-of-diabetes-mellitus-and-tuberculosis-in-china
#1
Jun Cheng, Hui Zhang, Yan Lin Zhao, Li Xia Wang, Ming Ting Chen
China has a double burden of diabetes mellitus and tuberculosis, and many studies have been carried out on the mutual impact of these two diseases. This paper systematically reviewed studies conducted in China covering the mutual impact of epidemics of diabetes and tuberculosis, the impact of diabetes on multi-drug resistant tuberculosis and on the tuberculosis clinical manifestation and treatment outcome, the yields of bi-directional screening, and economic evaluation for tuberculosis screening among diabetes patients...
May 2017: Biomedical and Environmental Sciences: BES
https://www.readbyqxmd.com/read/28549495/detection-of-the-urinary-biomarkers-pyd-ctx-ii-and-dpd-in-patients-with-kashin-beck-disease-in-the-qinghai-province-of-china
#2
Zhi Jun Zhao, Guang Lan Pu, Pei Zhen Zhan, Qiang Li, Chun Ning Wu, Li Hua Wang
Kashin-Beck disease (KBD) is an endemic degenerative osteoarthropathy of uncertain etiology. The aim of our study was to identify changes in C-telopeptide of type II collagen (CTX-II), pyridinoline (PYD), and deoxypyridinoline (DPD) among KBD patients. 54 KBD patients and 78 healthy controls were included this study. Urinary samples were collected and measured by ELISA. The median quantities of PYD, CTX-II, and DPD of KBD patients were 1107.73 ng/μmol.cre, 695.11 ng/μmol.cre, and 1342.34 pml/μmol.cre, while the median quantities of healthy controls were 805...
May 2017: Biomedical and Environmental Sciences: BES
https://www.readbyqxmd.com/read/28549494/antimicrobial-susceptibility-testing-and-molecular-characterization-of-mycobacterium-fortuitum-isolates-in-china
#3
Hui Wen Zheng, Yu Pang, Guang Xue He, Yuan Yuan Song, Yan Lin Zhao
We performed molecular identification of clinical isolates of Mycobacterium fortuitum (M. fortuitum) and conducted drug susceptibility testing to analyze the in vitro susceptibility of clinical M. fortuitum isolates and potential molecular mechanism conferring resistance to fluoroquinolone and macrolide drugs. The results showed that moxifloxacin had the highest in vitro activity against M. fortuitum, and most M. fortuitum isolates were resistant to clarithromycin and linezolid in China. The loss of genetic mutation in clarithromycin- and amikacin-resistant isolates indicates that some other intrinsic mechanism conferring clarithromycin and amikacin resistance plays an essential role in M...
May 2017: Biomedical and Environmental Sciences: BES
https://www.readbyqxmd.com/read/28549493/the-adverse-effect-of-the-2-1-1-regimen-for-rabies-pep-in-preschool-children
#4
Shu Qing Liu, Xiao Yan Tao, Peng Cheng Yu, Chun Qiu Jin, Hong Jie Yu, Mei Shun Chen, Wu Yang Zhu
Post-exposure prophylaxis (PEP) has proved to be the most important measure for rabies prevention and control. There is little information regarding adverse reactions to the Essen and 2-1-1 regimens in preschool children (aged 0-6). We reexamined the outcomes of 1,109 preschool children who were vaccinated using SPEEDA under the Essen regimen between January 2011 and December 2012 and 1,267 preschool children under the 2-1-1 regimen between January 2013 and December 2014. We find that, in preschool children, the febrile reaction after the first 2-dose injection in the 2-1-1 regimen was significantly higher than that induced by the first 1-dose in the Essen procedure...
May 2017: Biomedical and Environmental Sciences: BES
https://www.readbyqxmd.com/read/28549492/ginsenoside-rb1-attenuates-isoflurane-surgery-induced-cognitive-dysfunction-via-inhibiting-neuroinflammation-and-oxidative-stress
#5
Hui Hui Miao, Ye Zhang, Guan Nan Ding, Fang Xiao Hong, Peng Dong, Ming Tian
OBJECTIVE: Anesthetic isoflurane plus surgery has been reported to induce cognitive impairment. The underlying mechanism and targeted intervention remain largely to be determined. Ginsenoside Rb1 was reported to be neuroprotective. We therefore set out to determine whether ginsenoside Rb1 can attenuate isoflurane/surgery-induced cognitive dysfunction via inhibiting neuroinflammation and oxidative stress. METHODS: Five-months-old C57BL/6J female mice were treated with 1...
May 2017: Biomedical and Environmental Sciences: BES
https://www.readbyqxmd.com/read/28549491/increased-chondrocyte-apoptosis-in-kashin-beck-disease-and-rats-induced-by-t-2-toxin-and-selenium-deficiency
#6
Hao Jie Yang, Ying Zhang, Zhi Lun Wang, Sen Hai Xue, Si Yuan Li, Xiao Rong Zhou, Meng ZHANGg, Qian Fang, Wen Jun Wang, Chen Chen, Xiang Hua Deng, Jing Hong Chen
OBJECTIVE: To investigate chondrocyte apoptosis and the expression of biochemical markers associated with apoptosis in Kashin-Beck disease (KBD) and in an established T-2 toxin- and selenium (Se) deficiency-induced rat model. METHODS: Cartilages were collected from the hand phalanges of five patients with KBD and five healthy children. Sprague-Dawley rats were administered a selenium-deficient diet for 4 weeks prior to T-2 toxin exposure. The apoptotic chondrocytes were observed by terminal deoxynucleotidyl transferase dUTP nick end labeling staining...
May 2017: Biomedical and Environmental Sciences: BES
https://www.readbyqxmd.com/read/28549490/whole-genome-analysis-reveals-new-insights-into-macrolide-resistance-in-mycoplasma-pneumoniae
#7
Shao Li Li, Hong Mei Sun, Bao Li Zhu, Fei Liu, Han Qing Zhao
OBJECTIVE: Mutations in 23S rRNA gene are known to be associated with macrolide resistance in Mycoplasma pneumoniae (M. pneumoniae). However, these mutations alone do not fully explain the high resistance rates in Asia. The aim of this study was to investigate other possible mutations involved in macrolide resistance in M. pneumoniae. METHODS: The whole genomes of 10 clinical isolates of M. pneumoniae with macrolide resistance were sequenced by Illumina HiSeq2000 platform...
May 2017: Biomedical and Environmental Sciences: BES
https://www.readbyqxmd.com/read/28549489/blood-pressure-associated-with-arsenic-methylation-and-arsenic-metabolism-caused-by-chronic-exposure-to-arsenic-in-tube-well-water
#8
Bing Gan Wei, Bi Xiong Ye, Jiang Ping Yu, Lin Sheng Yang, Hai Rong Li, Ya Juan Xia, Ke Gong Wu
OBJECTIVE: The effects of arsenic exposure from drinking water, arsenic metabolism, and arsenic methylation on blood pressure (BP) were observed in this study. METHODS: The BP and arsenic species of 560 participants were determined. Logistic regression analysis was applied to estimate the odds ratios of BP associated with arsenic metabolites and arsenic methylation capability. RESULTS: BP was positively associated with cumulative arsenic exposure (CAE)...
May 2017: Biomedical and Environmental Sciences: BES
https://www.readbyqxmd.com/read/28549488/microwave-induced-apoptosis-and-cytotoxicity-of-nk-cells-through-erk1-2-signaling
#9
Li Zhao, Jing Li, Yan Hui Hao, Ya Bing Gao, Shui Ming Wang, Jing Zhang, Ji Dong, Hong Mei Zhou, Shu Chen Liu, Rui Yun Peng
OBJECTIVE: To investigate microwave-induced morphological and functional injury of natural killer (NK) cells and uncover their mechanisms. METHODS: NK-92 cells were exposed to 10, 30, and 50 mW/cm2 microwaves for 5 min. Ultrastructural changes, cellular apoptosis and cell cycle regulation were detected at 1 h and 24 h after exposure. Cytotoxic activity was assayed at 1 h after exposure, while perforin and NKG2D expression were detected at 1 h, 6 h, and 12 h after exposure...
May 2017: Biomedical and Environmental Sciences: BES
https://www.readbyqxmd.com/read/28549487/changes-in-waist-circumference-and-abdominal-obesity-among-chinese-adults-over-a-ten-year-period
#10
Yi Zhai, Hong Yun Fang, Wen Tao Yu, Dong Mei Yu, Li Yun Zhao, Xiao Feng Liang, Wen Hua Zhao
OBJECTIVE: The aim of this study was to describe changes in waist circumference (WC) and prevalence of abdominal obesity over a period of 10 years among Chinese adults in different socio-economic status (SES). METHODS: Data derived from the China Nutrition and Health Surveillance during 2002 and 2010-2012. We calculated the mean WC and the prevalence of abdominal obesity by gender, place of residence, SES indicators (education, income, and marital status), and body mass index (BMI) categoriesand used pooled t-tests to assess the differences between the two time periods...
May 2017: Biomedical and Environmental Sciences: BES
https://www.readbyqxmd.com/read/28494841/quercetin-attenuates-benzo-%C3%AE-pyrene-induced-cyp1a-expression
#11
M L Perepechaeva, T A Seredina, Y A Sidorova, E N Pivovarova, A L Markel, V V Lyakhovich, A Y Grishanova
We studied effects of nutrient quercetin on cytochromes' Р450 1А (CYP1A) activities (measured spectrofluorimetrically using 7-ethoxy-resorufin for CYP1A1 and 7-methoxy-resorufin for CYP1A2 as substrates), on mRNA levels (measured by RT-PCR), and on DNA-binding activities (evaluated by an electrophoretic mobility shift assay) of proteins regulating CYP1A expression in untreated and benzo(α)pyrene (BaP)-treated rats. Wistar rats received quercetin, BaP, or both once daily for 1-3 days. Quercetin did not influence CYP1A1 in untreated rats but inhibited BaP-mediated CYP1A induction on the transcriptional level decreasing positive input (AhR functional activity) and increasing negative input (AhRR/ARNT expression and Oct-1 and C/EBP functional activities)...
April 2017: Biomedical and Environmental Sciences: BES
https://www.readbyqxmd.com/read/28494840/differential-proteomics-reveals-the-potential-injury-mechanism-induced-by-heavy-ion-radiation-in-mice-ovaries
#12
Yu Xuan He, Hong Zhang, Hong Yan Li, Yong Zhang, Qi Peng Jia, Zong Shuai Li, Xing Xu Zhao
In the present study, we used a proteomics approach based on a two-dimensional electrophoresis (2-DE) reference map to investigate protein expression in the ovarian tissues of pubertal Swiss-Webster mice subjected to carbon ion radiation (CIR). Among the identified proteins, ubiquitin carboxy-terminal hydrolase L1 (UCH-L1) is associated with the cell cycle[1] and that it influences proliferation in ovarian tissues. We analyzed the expression of UCH-L1 and the proliferation marker proliferation cell nuclear antigen (PCNA) following CIR using immunoblotting and immunofluorescence...
April 2017: Biomedical and Environmental Sciences: BES
https://www.readbyqxmd.com/read/28494839/hexabromocyclododecane-induced-genotoxicity-in-cultured-human-breast-cells-through-dna-damage
#13
Rui Jing Li, Hui Gao, Guang Shui Na, Zi Hao Lu, Yao Yao, Fan Yang
To investigate the genotoxicity and reveal the potential toxicological mechanisms of Hexabromocyclododecane (HBCD), human breast cells HBL-100 were exposed to a sequence of HBCD concentrations (0, 5, 10, and 50 mg/L) for 24 h. With a series of zymology and molecular biology methods, we found that HBCD induced dose-dependent oxidative stress on HBL-100 DNA. As revealed in qRT-PCR, activated prognostic factor ATM down-regulated tumor suppressor gene BRCA1 and prompted DNA repair genes hOGG1 and hMTH1 expression in lower concentrations of HBCD (< 10 mg/L)...
April 2017: Biomedical and Environmental Sciences: BES
https://www.readbyqxmd.com/read/28494838/association-between-the-sumo4-m55v-polymorphism-and-susceptibility-to-type-2-diabetes-mellitus-a-meta-analysis
#14
Qun Zhang, Di Liu, Zhong Yao Zhao, Qi Sun, Li Xiang Ding, You Xin Wang
OBJECTIVE: The aim of this study is to determine whether the SUMO4 M55V polymorphism is associated with susceptibility to type 2 diabetes mellitus (T2DM). METHODS: A meta-analysis was performed to detect the potential association of the SUMO4 M55V polymorphism and susceptibility to T2DM under dominant, recessive, co-dominant (homogeneous and heterogeneous), and additive models. RESULTS: A total of eight articles including 10 case-control studies, with a total of 2932 cases and 2679 controls, were included in this meta-analysis...
April 2017: Biomedical and Environmental Sciences: BES
https://www.readbyqxmd.com/read/28494837/the-association-between-the-c5263t-mutation-in-the-mitochondrial-nd2-gene-and-coronary-heart-disease-among-young-chinese-han-people
#15
Guo Xin Han, Lei Xia, Shuo Shuo Li, Qin Hua Jin, Yang Song, Hong Shen, Li Li Wang, Ling Jie Kong, Tan Shi Li, Hai Yan Zhu
OBJECTIVE: This study aimed to investigate the genetic background of mitochondrial genes in young patients with Coronary heart disease (CHD) to provide a foundation for the early prevention of young patients with CHD. METHODS: 115 cases of young (⋜ 45 years) CHD Chinese Han patients (case group), 100 cases of older (> 45 years) Chinese Han CHD patients (experimental group) hospitalized and 100 cases of healthy people through physical examination (control group) at the General Hospital of PLA between January 2014 and December 2015 were selected...
April 2017: Biomedical and Environmental Sciences: BES
https://www.readbyqxmd.com/read/28494836/pulmonary-toxicity-in-rats-caused-by-exposure-to-intratracheal-instillation-of-sio2-nanoparticles
#16
Hong Yang, Qiu Yun Wu, Ming Yue Li, Can Shan Lao, Ying Jian Zhang
OBJECTIVE: The effect of the silica nanoparticles (SNs) on lungs injury in rats was investigated to evaluate the toxicity and possible mechanisms for SNs. METHODS: Male Wistar rats were instilled intratracheally with 1 mL of saline containing 6.25, 12.5, and 25.0 mg of SNs or 25.0 mg of microscale SiO2 particles suspensions for 30 d, were then sacrificed. Histopathological and ultrastructural change in lungs, and chemical components in the urine excretions were investigated by light microscope, TEM and EDS...
April 2017: Biomedical and Environmental Sciences: BES
https://www.readbyqxmd.com/read/28494835/validation-of-the-simplified-chinese-character-version-of-the-international-physical-activity-questionnaire-long-form-in-urban-community-dwelling-adults-a-cross-sectional-study-in-hangzhou-china
#17
Yan Jun Ren, Meng Su, Qing Min Liu, Ya Yun Tan, Yu Kun DU, Li Ming Li, Jun Lyu
OBJECTIVE: To assess the test-retest reliability and criterion validity of the Simplified Chinese-character version of the International Physical Activity Questionnaire Long form (IPAQ-L) in urban community-dwelling adults in Hanghzou, China. METHODS: A total of 158 eligible participants aged 25-59 years from 6 neighbourhoods in two central districts of Hangzhou completed the IPAQ-L questionnaire twice within a 7-day interval. Half of the subjects wore pedometers during the first 7 days...
April 2017: Biomedical and Environmental Sciences: BES
https://www.readbyqxmd.com/read/28494834/prediction-of-10-year-atherosclerotic-cardiovascular-disease-risk-among-adults-aged-40-79-years-in-china-a-nationally-representative-survey
#18
Mei Zhang, Yong Jiang, Li Min Wang, Yi Chong Li, Zheng Jing Huang, Jian Hong Li, Mai Geng Zhou, Wen Hua Zhao
OBJECTIVE: To establish the distribution of 10-year atherosclerotic cardiovascular disease (ASCVD) risk among Chinese adults. METHODS: We estimated the 10-year ASCVD risk by applying the 2013 American College of Cardiology/ American Heart Association pooled cohort equations (PCEs) to the data obtained from the 2010 China Chronic Disease and Risk Factor Surveillance that involved 61,541 participants (representing 520,158,652 Chinese adults) aged 40-79 years. We also compared the ASCVD risk with the 10-year ischemic cardiovascular disease (ICVD) risk, which was calculated using the simplified scoring tables recommended by the Chinese Guidelines for Prevention of Cardiovascular Diseases (Chinese model)...
April 2017: Biomedical and Environmental Sciences: BES
https://www.readbyqxmd.com/read/28494833/impact-of-smoking-status-on-lipoprotein-subfractions-data-from-an-untreated-chinese-cohort
#19
Xi Zhao, Hui Wen Zhang, Yan Zhang, Sha Li, Rui Xia Xu, Jing Sun, Cheng Gang Zhu, Na Qiong Wu, Ying Gao, Yuan Lin Guo, Geng Liu, Qian Dong, Jian Jun Li
OBJECTIVE: Cigarette smoking is one of the established risk factors of atherosclerotic cardiovascular disease, however, its impact on lipids is not completely understood, especially in the Chinese population. Therefore, this study evaluated the impact of smoking status (non, former, and current smoking) on the distribution of lipoprotein subfractions in untreated patients with angina-like chest pain. METHODS: A total of 877 patients were consecutively enrolled and divided into nonsmoking (n = 518), former smoking (n = 103), and current smoking (n = 256) groups...
April 2017: Biomedical and Environmental Sciences: BES
https://www.readbyqxmd.com/read/28427495/sexual-dysfunction-among-chinese-nurses-prevalence-and-predictors
#20
Yi Qun Yang, Qian Xu, Wei Jun Tong, Chun Lan Gao, Hong Mei Li
This study aimed to estimate the prevalence of and identify the factors influencing female sexual dysfunction (FSD) among Chinese nurses. A cross-sectional survey was conducted from March 2013 to May 2014 among 6 hospitals in Suzhou, China. In total, 2,030 married female nurses were included in the analysis. Data on the sociodemographic, lifestyle, and self-reported health status of the participants were collected, and the participants were asked to complete the Chinese version of the 19-item Female Sexual Function Index (FSFI) questionnaire...
March 2017: Biomedical and Environmental Sciences: BES
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