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Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists

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https://www.readbyqxmd.com/read/28318936/vector-model-supported-approach-in-prostate-plan-optimization
#1
Eva Sau Fan Liu, Vincent Wing Cheung Wu, Benjamin Harris, Margot Lehman, David Pryor, Lawrence Wing Chi Chan
Lengthy time consumed in traditional manual plan optimization can limit the use of step-and-shoot intensity-modulated radiotherapy/volumetric-modulated radiotherapy (S&S IMRT/VMAT). A vector model base, retrieving similar radiotherapy cases, was developed with respect to the structural and physiologic features extracted from the Digital Imaging and Communications in Medicine (DICOM) files. Planning parameters were retrieved from the selected similar reference case and applied to the test case to bypass the gradual adjustment of planning parameters...
March 17, 2017: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
https://www.readbyqxmd.com/read/28318935/vector-model-supported-optimization-in-volumetric-modulated-arc-stereotactic-radiotherapy-planning-for-brain-metastasis
#2
Eva Sau Fan Liu, Vincent Wing Cheung Wu, Benjamin Harris, Matthew Foote, Margot Lehman, Lawrence Wing Chi Chan
Long planning time in volumetric-modulated arc stereotactic radiotherapy (VMA-SRT) cases can limit its clinical efficiency and use. A vector model could retrieve previously successful radiotherapy cases that share various common anatomic features with the current case. The prsent study aimed to develop a vector model that could reduce planning time by applying the optimization parameters from those retrieved reference cases. Thirty-six VMA-SRT cases of brain metastasis (gender, male [n = 23], female [n = 13]; age range, 32 to 81 years old) were collected and used as a reference database...
March 17, 2017: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
https://www.readbyqxmd.com/read/28237294/automatic-planning-on-hippocampal-avoidance-whole-brain-radiotherapy
#3
Shuo Wang, Dandan Zheng, Chi Zhang, Rongtao Ma, Nathan R Bennion, Yu Lei, Xiaofeng Zhu, Charles A Enke, Sumin Zhou
Mounting evidence suggests that radiation-induced damage to the hippocampus plays a role in neurocognitive decline for patients receiving whole-brain radiotherapy (WBRT). Hippocampal avoidance whole-brain radiotherapy (HA-WBRT) has been proposed to reduce the putative neurocognitive deficits by limiting the dose to the hippocampus. However, urgency of palliation for patients as well as the complexities of the treatment planning may be barriers to protocol enrollment to accumulate further clinical evidence. This warrants expedited quality planning of HA-WBRT...
April 2017: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
https://www.readbyqxmd.com/read/28237293/method-of-predicting-the-mean-lung-dose-based-on-a-patient-s-anatomy-and-dose-volume-histograms
#4
Anna Zawadzka, Marta Nesteruk, Beata Brzozowska, Paweł F Kukołowicz
The aim of this study was to propose a method to predict the minimum achievable mean lung dose (MLD) and corresponding dosimetric parameters for organs-at-risk (OAR) based on individual patient anatomy. For each patient, the dose for 36 equidistant individual multileaf collimator shaped fields in the treatment planning system (TPS) was calculated. Based on these dose matrices, the MLD for each patient was predicted by the homemade DosePredictor software in which the solution of linear equations was implemented...
April 2017: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
https://www.readbyqxmd.com/read/28129973/acute-toxicity-and-its-dosimetric-correlates-for-high-risk-prostate-cancer-treated-with-moderately-hypofractionated-radiotherapy
#5
Moses Arunsingh, Indranil Mallick, Sriram Prasath, B Arun, Sandip Sarkar, Raj Kumar Shrimali, Sanjoy Chatterjee, Rimpa Achari
AIMS: To report the acute toxicity and the dosimetric correlates after moderately hypofractionated radiotherapy for localized prostate cancer. METHODS: A total of 101 patients with localized prostate cancer were treated with image-guided intensity-modulated radiation therapy. Patients were treated to 65Gy/25Fr/5 weeks (n = 18), or 60Gy/20Fr/4 weeks (n = 83). Most (82.2%) had high-risk or pelvic node-positive disease. Acute toxicity was assessed using Radiation Therapy Oncology Group (RTOG) acute morbidity scoring criteria...
April 2017: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
https://www.readbyqxmd.com/read/28129972/on-the-use-of-volumetric-modulated-arc-therapy-for-single-fraction-thoracic-vertebral-metastases-stereotactic-body-radiosurgery
#6
Damodar Pokhrel, Sumit Sood, Christopher McClinton, Xinglei Shen, Rajeev Badkul, Hongyu Jiang, Matthew Mallory, Mellissa Mitchell, Fen Wang, Christopher Lominska
To retrospectively evaluate quality, efficiency, and delivery accuracy of volumetric-modulated arc therapy (VMAT) plans for single-fraction treatment of thoracic vertebral metastases using image-guided stereotactic body radiosurgery (SBRS) after RTOG 0631 dosimetric compliance criteria. After obtaining credentialing for MD Anderson spine phantom irradiation validation, 10 previously treated patients with thoracic vertebral metastases with noncoplanar hybrid arcs using 1 to 2 3D-conformal partial arcs plus 7 to 9 intensity-modulated radiation therapy beams were retrospectively re-optimized with VMAT using 3 full coplanar arcs...
April 2017: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
https://www.readbyqxmd.com/read/28129971/dosimetric-aspects-of-breast-radiotherapy-with-three-dimensional-and-intensity-modulated-radiotherapy-helical-tomotherapy-planning-modules
#7
Poonam Yadav, Yue Yan, Tasha Ignatowski, Anna Olson
In this work, we investigated the dosimetric differences between the intensity-modulated radiotherapy (IMRT) plans and the three-dimensional (3D) helical plans based on the TomoTherapy system. A total of 15 patients with supine setup were randomly selected from the data base. For patients with lumpectomy planning target volume (PTV), regional lymph nodes were also included as part of the target. For dose sparing, the significant differences between the helical IMRT and helical 3D were only found in the heart and contralateral breast...
April 2017: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
https://www.readbyqxmd.com/read/28126476/optimization-of-brain-metastases-radiotherapy-with-tomohda
#8
Slav Yartsev, Glenn Bauman
An upgrade of the helical tomotherapy technology by introducing variable fan-field width (dynamic jaws) reduced the penumbra in superior-inferior direction for the target. Possible implementation of this upgrade even for the cases of the targets with different dose prescriptions is proposed. An example of brain metastasis in proximity to the optical apparatus in need of the whole brain irradiation of 30 Gy and higher dose to the lesion is considered.
April 2017: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
https://www.readbyqxmd.com/read/28126475/clinical-benefits-of-new-immobilization-system-for-hypofractionated-radiotherapy-of-intrahepatic-hepatocellular-carcinoma-by-helical-tomotherapy
#9
Yong Hu, Yong-Kang Zhou, Yi-Xing Chen, Shi-Ming Shi, Zhao-Chong Zeng
OBJECTIVE: A comprehensive clinical evaluation was conducted, assessing the Body Pro-Lok immobilization and positioning system to facilitate hypofractionated radiotherapy of intrahepatic hepatocellular carcinoma (HCC), using helical tomotherapy to improve treatment precision. METHODS: Clinical applications of the Body Pro-Lok system were investigated (as above) in terms of interfractional and intrafractional setup errors and compressive abdominal breath control...
April 2017: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
https://www.readbyqxmd.com/read/28126474/can-cost-make-a-difference-dosimetrically-volumetric-modulated-arc-therapy-study-for-multileaf-collimators-of-various-widths-for-head-and-neck-and-prostate-cancers
#10
Jong-Han Ho, Shane Hagler, Carrie Lujano, Sopaul Seng, Christine Starks, Kelly Perrin, Lehendrick Turner, Laurence Court
Cancer is a global health issue that disproportionately kills based on stage of disease, cellular pathology, and genetics, to name a few. Another variable to consider in this ongoing fight is treatment machine complexity that leads to elevated development and purchasing cost, leading to a reduced use. Reducing the complexity (in hopes of lowering costs) would benefit underdeveloped, low- and middle-income countries by introducing newer treatment technology, as their currently accepted standards do not meet standards of more advanced, developed countries...
April 2017: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
https://www.readbyqxmd.com/read/28126473/the-dilemma-of-parotid-gland-and-pharyngeal-constrictor-muscles-preservation-is-daily-online-image-guidance-required-a-dosimetric-analysis
#11
Olivia Duffy, Elizabeth Forde, Michelle Leech
With margin reduction common in head and neck radiotherapy, it is critical that the dosimetric effects of setup deviations are quantified. With past studies focusing on the quantification of positional and volumetric changes of organs at risk (OARs), this study aimed to measure the dose delivered to these the parotid gland (PG) and pharyngeal constrictor muscles (PCMs) using cone beam computed tomography (CBCT). Furthermore, this investigation sought to establish a potential time trend of change in dose delivered to target volumes secondary to ascertaining the need for daily image guidance (IG) to reduce the dose burden to these important OARs...
April 2017: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
https://www.readbyqxmd.com/read/28126472/dosimetric-effect-of-beam-arrangement-for-intensity-modulated-radiation-therapy-in-the-treatment-of-upper-thoracic-esophageal-carcinoma
#12
Yuchuan Fu, Min Deng, Xiaojuan Zhou, Qiang Lin, Bin Du, Xue Tian, Yong Xu, Jin Wang, You Lu, Youling Gong
To evaluate the lung sparing in intensity-modulated radiation therapy (IMRT) for patients with upper thoracic esophageal tumors extending inferiorly to the thorax by different beam arrangement. Overall, 15 patient cases with cancer of upper thoracic esophagus were selected for a retrospective treatment-planning study. Intensity-modulated radiation therapy plans using 4, 5, and 7 beams (4B, 5B, and 7B) were developed for each patient by direct machine parameter optimization (DMPO). All plans were evaluated with respect to dose volumes to irradiated targets and normal structures, with statistical comparisons made between 4B with 5B and 7B intensity-modulated radiation therapy plans...
April 2017: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
https://www.readbyqxmd.com/read/27919621/a-comparative-study-of-standard-intensity-modulated-radiotherapy-and-rapidarc-planning-techniques-for-ipsilateral-and-bilateral-head-and-neck-irradiation
#13
Jennifer Pursley, Antonio L Damato, Maria A Czerminska, Danielle N Margalit, David J Sher, Roy B Tishler
The purpose of this study was to investigate class solutions using RapidArc volumetric-modulated arc therapy (VMAT) planning for ipsilateral and bilateral head and neck (H&N) irradiation, and to compare dosimetric results with intensity-modulated radiotherapy (IMRT) plans. A total of 14 patients who received ipsilateral and 10 patients who received bilateral head and neck irradiation were retrospectively replanned with several volumetric-modulated arc therapy techniques. For ipsilateral neck irradiation, the volumetric-modulated arc therapy techniques included two 360° arcs, two 360° arcs with avoidance sectors around the contralateral parotid, two 260° or 270° arcs, and two 210° arcs...
April 2017: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
https://www.readbyqxmd.com/read/27839693/pencil-beam-scanning-proton-therapy-vs-rotational-arc-radiation-therapy-a-treatment-planning-comparison-for-postoperative-oropharyngeal-cancer
#14
Ontida Apinorasethkul, Maura Kirk, Kevin Teo, Samuel Swisher-McClure, John N Lukens, Alexander Lin
Patients diagnosed with head and neck cancer are traditionally treated with photon radiotherapy. Proton therapy is currently being used clinically and may potentially reduce treatment-related toxicities by minimizing the dose to normal organs in the treatment of postoperative oropharyngeal cancer. The finite range of protons has the potential to significantly reduce normal tissue toxicity compared to photon radiotherapy. Seven patients were planned with both proton and photon modalities. The planning goal for both modalities was achieving the prescribed dose to 95% of the planning target volume (PTV)...
April 2017: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
https://www.readbyqxmd.com/read/27751618/bladder-radiotherapy-treatment-a-retrospective-comparison-of-3-dimensional-conformal-radiotherapy-intensity-modulated-radiation-therapy-and-volumetric-modulated-arc-therapy-plans
#15
Katia Pasciuti, Shrinivas Kuthpady, Anne Anderson, Bronagh Best, Saleem Waqar, Subhra Chowdhury
To examine tumor׳s and organ׳s response when different radiotherapy plan techniques are used. Ten patients with confirmed bladder tumors were first treated using 3-dimensional conformal radiotherapy (3DCRT) and subsequently the original plans were re-optimized using the intensity-modulated radiation treatment (IMRT) and volumetric-modulated arc therapy (VMAT)-techniques. Targets coverage in terms of conformity and homogeneity index, TCP, and organs׳ dose limits, including integral dose analysis were evaluated...
April 2017: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
https://www.readbyqxmd.com/read/27839589/anatomical-contouring-variability-in-thoracic-organs-at-risk
#16
Ross McCall, Grayden MacLennan, Matthew Taylor, Nishele Lenards, Benjamin E Nelms, Matthew Koshy, Jeffrey Lemons, Ashley Hunzeker
The purpose of this study was to determine whether contouring thoracic organs at risk was consistent among medical dosimetrists and to identify how trends in dosimetrist׳s education and experience affected contouring accuracy. Qualitative and quantitative methods were used to contextualize the raw data that were obtained. A total of 3 different computed tomography (CT) data sets were provided to medical dosimetrists (N = 13) across 5 different institutions. The medical dosimetrists were directed to contour the lungs, heart, spinal cord, and esophagus...
January 2016: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
https://www.readbyqxmd.com/read/27839588/hybrid-isocenter-technique-for-gamma-knife-perfexion-treatment-of-trigeminal-neuralgia
#17
Young-Bin Cho, Normand Laperriere, Mojgan Hodaie, Caroline Chung
Gamma-Knife (GK), Perfexion (PFX) has 8 sectors that can be blocked compared with the older model 4C, which has 201 independent source blocking options using plugs. This limits the ability of PFX to shape a single isocenter plan, such as trigeminal neuralgia. In this retrospective review and prospective re-planning comparison study of trigeminal neuralgia radiosurgery plans, a hybrid isocenter technique (HIT) is compared with single isocenter GK radiosurgery plans on 2 models (4C and PFX) dosimetric parameters...
January 2016: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
https://www.readbyqxmd.com/read/27765542/dosimetric-comparison-of-helical-tomotherapy-intensity-modulated-radiation-therapy-volumetric-modulated-arc-therapy-and-3-dimensional-conformal-therapy-for-the-treatment-of-t1n0-glottic-cancer
#18
Kemal Ekici, Eda K Pepele, Bahaddin Yaprak, Oztun Temelli, Aysun F Eraslan, Nadir Kucuk, Ayse Y Altınok, Pelin A Sut, Ozlem D Alpak, Cemil Colak, Alpaslan Mayadagli
Various radiotherapy planning methods for T1N0 laryngeal cancer have been proposed to decrease normal tissue toxicity. We compare helical tomotherapy (HT), linac-based intensity-modulated radiation therapy (IMRT), volumetric-modulated arc therapy (VMAT), and 3-D conformal radiotherapy (3D-CRT) techniques for T1N0 laryngeal cancer. Overall, 10 patients with T1N0 laryngeal cancer were selected and evaluated. Furthermore, 10 radiotherapy treatment plans have been created for all 10 patients, including HT, IMRT, VMAT, and 3D-CRT...
January 2016: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
https://www.readbyqxmd.com/read/27751617/single-fraction-flattening-filter-free-volumetric-modulated-arc-therapy-for-lung-cancer-dosimetric-results-and-comparison-with-flattened-beams-technique
#19
Sara Barbiero, Alexandra Rink, Fabrizio Matteucci, David Fedele, Fabiola Paiar, Francesco Pasqualetti, Michele Avanzo
PURPOSE: To report on single-fraction stereotactic body radiotherapy (RT) (SBRT) with flattening filter (FF)-free (FFF) volumetric modulated arc therapy (VMAT) for lung cancer and to compare dosimetric results with VMAT with FF. METHODS AND MATERIALS: Overall, 25 patients were treated with 6-MV FFF VMAT (Varian TrueBeam STx LINAC) to a prescribed dose of 24Gy in a single fraction. Treatment plans were recreated using FF VMAT. Dose-volume indices, monitor units (MU), and treatment times were compared between FFF and FF VMAT techniques...
January 2016: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
https://www.readbyqxmd.com/read/27745996/neurovascular-bundle-sparing-radiotherapy-for-prostate-cancer-using-mri-ct-registration-a-dosimetric-feasibility-study
#20
R J Cassidy, X Yang, T Liu, M Thomas, S G Nour, A B Jani
PURPOSE: Sexual dysfunction after radiotherapy for prostate cancer remains an important late adverse toxicity. The neurovascular bundles (NVB) that lie posterolaterally to the prostate are typically spared during prostatectomy, but in traditional radiotherapy planning they are not contoured as an organ-at-risk with dose constraints. Our goal was to determine the dosimetric feasibility of "NVB-sparing" prostate radiotherapy while still delivering adequate dose to the prostate. METHODS: Twenty-five consecutive patients with prostate cancer (with no extraprostatic disease on pelvic magnetic resonance imaging [MRI]) who that were treated with external beam radiotherapy, with the same primary planning target volume margins, to a dose of 79...
January 2016: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
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