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Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists

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https://www.readbyqxmd.com/read/28527605/analysis-of-gafchromic-ebt3-film-calibration-irradiated-with-gamma-rays-from-different-systems-gamma-knife-and-cobalt-60-unit
#1
Monsen Najafi, Ghazale Geraily, Alireza Shirazi, Mahbod Esfahani, Javad Teimouri
In recent years, Gafchromic films are used as an advanced instrument for dosimetry systems. The EBT3 films are a new generation of Gafchromic films. Our main interest is to compare the response of the EBT3 films exposed to gamma rays provided by the Theratron 780C as a conventional radiotherapy system and the Leksell Gamma Knife as a stereotactic radiotherapy system (SRS). Both systems use Cobalt-60 sources, thus using the same energy. However, other factors such as source-to-axis distance, number of sources, dose rate, direction of irradiation, shape of phantom, the field shape of radiation, and different scatter contribution may influence the calibration curve...
May 17, 2017: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
https://www.readbyqxmd.com/read/28526193/effects-of-multiple-breath-hold-reproducibility-on-treatment-localization-and-dosimetric-accuracy-in-radiotherapy-of-left-sided-breast-cancer-with-voluntary-deep-inspiration-breath-hold-technique
#2
Mika Kapanen, Marko Laaksomaa, Jani Pehkonen, Mikko Haltamo, Helmi Luukkanen, Turkka Lehtonen, Simo Hyödynmaa, Pirkko-Liisa Kellokumpu-Lehtinen
The purpose of this study was to investigate the effects of breath hold reproducibility on positional and dosimetric errors in radiotherapy of patients with left-sided breast cancer (LSBC) treated with voluntary deep inspiration breath hold (vDIBH) technique. Clinical data from 2 groups of patients with LSBC were retrospectively investigated: (1) those irradiated for the whole breast only (WB group, n = 20) using typically from 3 to 5 breath holds per treatment session and (2) those irradiated simultaneously also for supraclavicular lymph nodes (WB + SLN group, n = 27) using from 7 to 9 breath holds per fraction...
May 16, 2017: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
https://www.readbyqxmd.com/read/28526192/comparison-of-spinal-stereotactic-body-radiotherapy-sbrt-planning-techniques-intensity-modulated-radiation-therapy-modulated-arc-therapy-and-helical-tomotherapy
#3
Jina Kim, Hong Seok Jang, Yeon Sil Kim, Byung Ock Choi, Young-Nam Kang
Stereotactic body radiotherapy (SBRT) delivers a highly conformal, hypofractionated radiation dose to a small target with minimal radiation applied to the surrounding areas. Therefore, using the proper treatment planning techniques for SBRT is important. Intensity modulation techniques, such as static intensity-modulated radiation therapy (IMRT), modulated arc therapy (mARC), and helical tomotherapy (HT), are useful for spinal SBRT because of a rapid dose fall-off and spinal cord avoidance. This study compared the planning characteristics for hypofractionated spinal SBRT administered using 3 treatment techniques...
May 16, 2017: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
https://www.readbyqxmd.com/read/28506589/the-relationship-between-dosimetric-factors-side-effects-and-survival-in-patients-with-non-small-cell-lung-cancer-treated-with-definitive-radiotherapy
#4
Dilruba Okumus, Sureyya Sarihan, Sema Gozcu, Deniz Sigirli
The patients with non-small cell lung cancer (NSCLC) treated with definitive conformal radiotherapy (RT) were evaluated in terms of side effects and survival. Normal tissue complication probability (NTCP) was calculated for 68 patients treated between 2009 and 2012. Clinical and dosimetric factors were analyzed. The median dose of 63 Gy (range: 54 to 70 Gy) was given with conformal RT with blocks (n = 37), 3-dimensional conformal RT (3DCRT) (n = 11), or intensity-modulated RT (IMRT) (n = 20)...
May 12, 2017: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
https://www.readbyqxmd.com/read/28502654/radiation-induced-hypothyroidism-in-patients-with-breast-cancer-a-retrospective-analysis-of-243-cases
#5
Gul Kanyilmaz, Meryem Aktan, Mehmet Koc, Hikmettin Demir, Lutfi Saltuk Demir
This study aims to estimate the incidence of hypothyroidism (HT) and to evaluate the predictors affecting the development of HT after radiotherapy (RT) for breast cancer, with a focus on radiation dose-volumetric parameters. Between 2009 and 2015, 243 patients undergoing RT for breast cancer were retrospectively analyzed. Free triiodothyronine (FT3), free thyroxin (FT4), and thyrotropin (TSH) were monitored before and after RT. The relation between the doses to thyroid gland (Dmean, Dmax, Dmin), percentage of thyroid volume receiving > 10 Gy, 20 Gy, 30 Gy, 40 Gy, and 50 Gy (V10 to V50), absolute thyroid volume, and HT were analyzed...
May 11, 2017: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
https://www.readbyqxmd.com/read/28502653/heart-sparing-radiotherapy-in-patients-with-breast-cancer-what-are-the-techniques-used-in-the-clinical-routine-a-pattern-of-practice-survey-in-the-german-speaking-countries
#6
Marciana-Nona Duma, Stefan Münch, Markus Oechsner, Stephanie E Combs
The aim of this study was to understand the practice of care in German-speaking countries with regard to heart-sparing radiotherapy techniques. Between August 2015 and September 2015, an e-mail/fax-based survey was sent to radiation oncology departments in Germany, Austria, and the German-speaking Switzerland. The questionnaire was divided into 3 chapters: a general chapter on the department, a chapter specific for heart-sparing techniques in patients with breast cancer, and a third chapter on personal beliefs on the topic of heart sparing in patients with breast cancer...
May 11, 2017: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
https://www.readbyqxmd.com/read/28495033/clinical-applications-of-3-dimensional-printing-in-radiation-therapy
#7
Yizhou Zhao, Kathryn Moran, Mammo Yewondwossen, James Allan, Scott Clarke, Murali Rajaraman, Derek Wilke, Paul Joseph, James L Robar
Three-dimensional (3D) printing is suitable for the fabrication of complex radiotherapy bolus. Although investigated from dosimetric and feasibility standpoints, there are few reports to date of its use for actual patient treatment. This study illustrates the versatile applications of 3D printing in clinical radiation oncology through a selection of patient cases, namely, to create bolus for photon and modulated electron radiotherapy (MERT), as well as applicators for surface high-dose rate (HDR) brachytherapy...
May 8, 2017: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
https://www.readbyqxmd.com/read/28479012/whole-brain-irradiation-field-design-a-comparison-of-parotid-dose
#8
Cheng-Chia Wu, Yen-Ruh Wuu, Ashish Jani, Anurag Saraf, Cheng-Hung Tai, Matthew E Lapa, Jacquelyn I S Andrew, Akhil Tiwari, Heva J Saadatmand, Steven R Isaacson, Simon K Cheng, Tony J C Wang
Whole-brain radiation therapy (WBRT) plays an important role in patients with diffusely metastatic intracranial disease. Whether the extent of the radiation field design to C1 or C2 affects parotid dose and risk for developing xerostomia is unknown. The goal of this study is to examine the parotid dose based off of the inferior extent of WBRT field to either C1 or C2. Patients treated with WBRT with either 30 Gy or 37.5 Gy from 2011 to 2014 at a single institution were examined. Parotid dose constraints were compared with Radiation Therapy Oncology Group (RTOG) 0615 nasopharyngeal carcinoma for a 33-fraction treatment: mean <26 Gy, volume constraint at 20 Gy (V20) < 20 cc, and dose at 50% of the parotid volume (D50) < 30 Gy...
May 4, 2017: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
https://www.readbyqxmd.com/read/28478867/targeting-accuracy-of-single-isocenter-intensity-modulated-radiosurgery-for-multiple-lesions
#9
J F Calvo-Ortega, M Pozo, S Moragues, J Casals
To investigate the targeting accuracy of intensity-modulated SRS (IMRS) plans designed to simultaneously treat multiple brain metastases with a single isocenter. A home-made acrylic phantom able to support a film (EBT3) in its coronal plane was used. The phantom was CT scanned and three coplanar small targets (a central and two peripheral) were outlined in the Eclipse system. Peripheral targets were 6 cm apart from the central one. A reference IMRS plan was designed to simultaneously treat the three targets, but only a single isocenter located at the center of the central target was used...
May 3, 2017: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
https://www.readbyqxmd.com/read/28476456/dosimetric-comparison-of-single-beam-multi-arc-and-2-beam-multi-arc-vmat-optimization-in-the-monaco-treatment-planning-system
#10
Alan M Kalet, Hannah L Richardson, Darrin A Nikolaisen, Ning Cao, Myra A Lavilla, Claire Dempsey, Juergen Meyer, Wui-Jin Koh, Kenneth J Russell
The purpose of this study was to evaluate the dosimetric and practical effects of the Monaco treatment planning system "max arcs-per-beam" optimization parameter in pelvic radiotherapy treatments. We selected for this study a total of 17 previously treated patients with a range of pelvic disease sites including prostate (9), bladder (1), uterus (3), rectum (3), and cervix (1). For each patient, 2 plans were generated, one using an arc-per-beam setting of "1" and another with an arc-per-beam setting of "2" using the volumes and constraints established from the initial clinical treatments...
May 2, 2017: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
https://www.readbyqxmd.com/read/28457723/dosimetric-effect-of-multileaf-collimator-leaf-width-on-volumetric-modulated-arc-stereotactic-radiotherapy-for-spine-tumors
#11
Ahmad Amoush, Huang Long, Laxmi Subedi, Peng Qi, Toufik Djemil, Ping Xia
This work aimed to study the dosimetric effect of multileaf collimator (MLC) leaf widths in treatment plans for patients receiving volumetric modulated arc therapy (VMAT) for spine stereotactic body radiation therapy (SBRT). Thirteen patients treated with spine SBRT were retrospectively selected for this study. The patients were treated following the protocol of the Radiation Therapy Oncology Group 0631 (RTOG 0631) for spine metastasis. The prescription dose was 16 Gy in 1 fraction to 90% of the target volume (V16 > 90%)...
April 28, 2017: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
https://www.readbyqxmd.com/read/28438431/phantom-to-clinic-development-of-hypofractionated-stereotactic-body-radiotherapy-for-early-stage-glottic-laryngeal-cancer
#12
Chuxiong Ding, Stephen G Chun, Baran D Sumer, Lucien A Nedzi, Ramzi E Abdulrahman, John S Yordy, Pam Lee, Brian Hrycushko, Timothy D Solberg, Chul Ahn, Robert D Timmerman, David L Schwartz
The purpose of this study was to commission and clinically test a robotic stereotactic delivery system (CyberKnife, Sunnyvale, CA) to treat early-stage glottic laryngeal cancer. We enrolled 15 patients with cTis-T2N0M0 carcinoma of the glottic larynx onto an institutional review board (IRB)-approved clinical trial. Stereotactic body radiotherapy (SBRT) plans prescribed 45 Gy/10 fractions to the involved hemilarynx. SBRT dosimetry was compared with (1) standard carotid-sparing laryngeal intensity-modulated radiation therapy (IMRT) and (2) selective hemilaryngeal IMRT...
April 21, 2017: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
https://www.readbyqxmd.com/read/28433482/variations-of-target-volume-definition-and-daily-target-volume-localization-in-stereotactic-body-radiotherapy-for-early-stage-non-small-cell-lung-cancer-patients-under-abdominal-compression
#13
Chunhui Han, Sagus Sampath, Timothy E Schultheisss, Jeffrey Y C Wong
We aimed to compare gross tumor volumes (GTV) in 3-dimensional computed tomography (3DCT) simulation and daily cone beam CT (CBCT) with the internal target volume (ITV) in 4-dimensional CT (4DCT) simulation in stereotactic body radiotherapy (SBRT) treatment of patients with early-stage non-small cell lung cancer (NSCLC) under abdominal compression. We retrospectively selected 10 patients with NSCLC who received image-guided SBRT treatments under abdominal compression with daily CBCT imaging. GTVs were contoured as visible gross tumor on the planning 3DCT and daily CBCT, and ITVs were contoured using maximum intensity projection (MIP) images of the planning 4DCT...
April 19, 2017: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
https://www.readbyqxmd.com/read/28392229/impact-of-intravenous-contrast-used-in-computed-tomography-on-radiation-dose-to-carotid-arteries-and-thyroid-in-intensity-modulated-radiation-therapy-planning-for-nasopharyngeal-carcinoma
#14
Victor Ho Fun Lee, Sherry Chor Yi Ng, Dora Lai Wan Kwong, Ka On Lam, To Wai Leung
The aim of this study was to investigate if intravenous contrast injection affected the radiation doses to carotid arteries and thyroid during intensity-modulated radiation therapy (IMRT) planning for nasopharyngeal carcinoma (NPC). Thirty consecutive patients with NPC underwent plain computed tomography (CT) followed by repeated scanning after contrast injection. Carotid arteries (common, external, internal), thyroid, target volumes, and other organs-at-risk (OARs), as well as IMRT planning, were based on contrast-enhanced CT (CE-CT) images...
April 6, 2017: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
https://www.readbyqxmd.com/read/28392228/subungual-squamous-cell-carcinoma-a-case-study
#15
Cory J Neill
The purpose of this case study is to describe a dosimetric delivery of radiation to a superficial disease process involving the skin and bone of the distal finger. A 76-year-old male patient presented with a subungual squamous cell carcinoma (SCC) of the left distal index finger with bony involvement. The patient refused conventional surgical treatment but agreed to external beam radiation therapy (EBRT). There is a gap in the current literature describing how to successfully immobilize fingers and which EBRT modality is dosimetrically advantageous in treating them...
April 6, 2017: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
https://www.readbyqxmd.com/read/28318936/vector-model-supported-approach-in-prostate-plan-optimization
#16
Eva Sau Fan Liu, Vincent Wing Cheung Wu, Benjamin Harris, Margot Lehman, David Pryor, Lawrence Wing Chi Chan
Lengthy time consumed in traditional manual plan optimization can limit the use of step-and-shoot intensity-modulated radiotherapy/volumetric-modulated radiotherapy (S&S IMRT/VMAT). A vector model base, retrieving similar radiotherapy cases, was developed with respect to the structural and physiologic features extracted from the Digital Imaging and Communications in Medicine (DICOM) files. Planning parameters were retrieved from the selected similar reference case and applied to the test case to bypass the gradual adjustment of planning parameters...
March 18, 2017: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
https://www.readbyqxmd.com/read/28318935/vector-model-supported-optimization-in-volumetric-modulated-arc-stereotactic-radiotherapy-planning-for-brain-metastasis
#17
Eva Sau Fan Liu, Vincent Wing Cheung Wu, Benjamin Harris, Matthew Foote, Margot Lehman, Lawrence Wing Chi Chan
Long planning time in volumetric-modulated arc stereotactic radiotherapy (VMA-SRT) cases can limit its clinical efficiency and use. A vector model could retrieve previously successful radiotherapy cases that share various common anatomic features with the current case. The prsent study aimed to develop a vector model that could reduce planning time by applying the optimization parameters from those retrieved reference cases. Thirty-six VMA-SRT cases of brain metastasis (gender, male [n = 23], female [n = 13]; age range, 32 to 81 years old) were collected and used as a reference database...
March 17, 2017: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
https://www.readbyqxmd.com/read/28433483/functional-image-guided-stereotactic-body-radiation-therapy-planning-for-patients-with-hepatocellular-carcinoma
#18
Uranchimeg Tsegmed, Tomoki Kimura, Takeo Nakashima, Yuko Nakamura, Toru Higaki, Nobuki Imano, Yoshiko Doi, Masahiro Kenjo, Shuichi Ozawa, Yuji Murakami, Kazuo Awai, Yasushi Nagata
The aim of the current planning study is to evaluate the ability of gadoxetate disodium-enhanced magnetic resonance imaging (EOB-MRI)-guided stereotactic body radiation therapy (SBRT) planning by using intensity-modulated radiation therapy (IMRT) techniques in sparing the functional liver tissues during SBRT for hepatocellular carcinoma. In this study, 20 patients with hepatocellular carcinoma were enrolled. Functional liver tissues were defined according to quantitative liver-spleen contrast ratios ≥ 1...
July 2017: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
https://www.readbyqxmd.com/read/28237294/automatic-planning-on-hippocampal-avoidance-whole-brain-radiotherapy
#19
Shuo Wang, Dandan Zheng, Chi Zhang, Rongtao Ma, Nathan R Bennion, Yu Lei, Xiaofeng Zhu, Charles A Enke, Sumin Zhou
Mounting evidence suggests that radiation-induced damage to the hippocampus plays a role in neurocognitive decline for patients receiving whole-brain radiotherapy (WBRT). Hippocampal avoidance whole-brain radiotherapy (HA-WBRT) has been proposed to reduce the putative neurocognitive deficits by limiting the dose to the hippocampus. However, urgency of palliation for patients as well as the complexities of the treatment planning may be barriers to protocol enrollment to accumulate further clinical evidence. This warrants expedited quality planning of HA-WBRT...
April 2017: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
https://www.readbyqxmd.com/read/28237293/method-of-predicting-the-mean-lung-dose-based-on-a-patient-s-anatomy-and-dose-volume-histograms
#20
Anna Zawadzka, Marta Nesteruk, Beata Brzozowska, Paweł F Kukołowicz
The aim of this study was to propose a method to predict the minimum achievable mean lung dose (MLD) and corresponding dosimetric parameters for organs-at-risk (OAR) based on individual patient anatomy. For each patient, the dose for 36 equidistant individual multileaf collimator shaped fields in the treatment planning system (TPS) was calculated. Based on these dose matrices, the MLD for each patient was predicted by the homemade DosePredictor software in which the solution of linear equations was implemented...
April 2017: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
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