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Respiratory Medicine

Bridget F Collins, Ganesh Raghu
No abstract text is available yet for this article.
October 27, 2018: Respiratory Medicine
Adam S Morgenthau
No abstract text is available yet for this article.
October 6, 2018: Respiratory Medicine
Athol U Wells
No abstract text is available yet for this article.
October 6, 2018: Respiratory Medicine
Elizabeth V Arkema, Anders Eklund, Johan Grunewald, Gustaf Bruze
BACKGROUND: Information on how sarcoidosis affects one's ability to work is needed to clarify the burden of disease on the individual and society. Our aim was to describe the work ability of individuals with sarcoidosis before and after diagnosis compared to people without sarcoidosis. METHODS: Swedish national registers were used to identify adults diagnosed with sarcoidosis aged 25-59 years old and matched general population comparators without sarcoidosis 2006-2012...
October 5, 2018: Respiratory Medicine
Jaya Muneswarao, Mohamed Azmi Hassali, Ashutosh Kumar Verma
No abstract text is available yet for this article.
September 19, 2018: Respiratory Medicine
Bradley J Petek, David G Rosenthal, Kristen K Patton, Sanaz Behnia, Jonathan M Keller, Bridget F Collins, Richard K Cheng, Lawrence A Ho, Paco E Bravo, Carmen Mikacenic, Ganesh Raghu
INTRODUCTION: The diagnosis of cardiac sarcoidosis (CS) is difficult to ascertain due to the insensitivity of endomyocardial biopsy. Current diagnostic criteria require a positive endomyocardial biopsy or extra-cardiac biopsy with clinical features suggestive of CS. Common tests for diagnosis of pulmonary sarcoidosis include bronchoalveolar lavage (BAL), lung and mediastinal lymph node (MLN) biopsies. Our objective was to determine the diagnostic utility of these tests in patients with suspected CS and without prior history of pulmonary involvement...
September 16, 2018: Respiratory Medicine
Bridget F Collins, Robyn L McClelland, Lawrence A Ho, Carmen R Mikacenic, Jennifer Hayes, Carolyn Spada, Ganesh Raghu
BACKGROUND: Idiopathic Pulmonary Fibrosis (IPF) and Sarcoidosis are distinct clinical entities. Fibrotic disease in pulmonary sarcoidosis is typically upper lobe predominant. In IPF fibrosis is basilar and peripheral predominant [usual interstitial pneumonia (UIP) pattern]. Sarcoidosis and UIP have rarely been observed in the same patient. We sought to characterize patients manifesting both sarcoidosis and IPF and compare clinical features and survival to that of patients with "Lone-IPF" (IPF only) and pulmonary sarcoidosis with fibrosis in a non-UIP pattern...
August 23, 2018: Respiratory Medicine
John R Bach, Susan B Liu, Nikhil Potpally, Yuka Ishikawa, Miguel R Gonçalves
No abstract text is available yet for this article.
August 22, 2018: Respiratory Medicine
Joan B Soriano, Francisco García-Río, Emma Vázquez-Espinosa, Jose Ignacio Conforto, Ascensión Hernando-Sanz, Luis López-Yepes, Raúl Galera-Martínez, Germán Peces-Barba, Carolina María Gotera-Rivera, M Teresa Pérez-Warnisher, Gonzalo Segrelles-Calvo, Celia Zamarro, Pablo González-Ponce, M Inmaculata Ramos, Syed Jafri, Julio Ancochea
BACKGROUND: Evidence is needed to determine the role of telehealth (TH) in COPD management. METHODS: PROMETE II was a multicentre, randomized, 12-month trial. Severe COPD patients in stable condition were randomized to a specific monitoring protocol with TH or routine clinical practice (RCP). The primary objective was to reduce the number of COPD exacerbations leading to ER visits/hospital admissions between groups. RESULTS: Overall, 237 COPD patients were screened, and 229 (96...
November 2018: Respiratory Medicine
Sophie Freitag, Stephanie Hallebach, Irene Baumann, Petra Kalischewski, Beate Rassler
BACKGROUND: Myasthenia gravis (MG) is characterized by reduced muscle endurance and often leads to respiratory complications. OBJECTIVE: A long-term respiratory muscle endurance training (RMET) based on normocapnic hyperpnea was introduced for the first time in MG patients. We investigated RMET effects on respiratory endurance (RE), MG symptoms, lung function and physical fitness and compared the results with a control group (CG). METHODS: The training period consisted of four weeks intensive training (IT; five 30-min training sessions per week) followed by twelve months maintenance training (MT; five 30-min training sessions over two weeks)...
November 2018: Respiratory Medicine
Suneela Zaigham, Linda Johnson, Per Wollmer, Gunnar Engström
BACKGROUND: Although reduced lung function is associated with both COPD and coronary events (CE), the pattern of lung function impairment could be different for the two outcomes. We examined different measures of lung function in relation to incident COPD events and CE in a population-based cohort. METHODS: Baseline spirometry and lung clearance index (LCI) were assessed in 672 men aged 55 years. Outcomes included incident COPD events and CE (hospitalisation or mortality)...
November 2018: Respiratory Medicine
Maria Vera Cruz de Oliveira, Emilio Pizzichini, Claudia Henrique da Costa, Carlos Cezar Fritscher, Elcio Oliveira Vianna, Paulo José Zimermann Teixeira, Roberto Stirbulov, Marcelo Fouad Rabahi, Nadine Cordeiro de Pinho
The INHALATOR study was a randomized, multicentre, open label, two-period of 7 days each, crossover study, with 7 days of washout in-between, aiming to evaluate the correct use, satisfaction and preference between Breezhaler® and Respimat® devices in patients under daily use of open Spiriva® or open Onbrize® , as monotherapy for treatment of mild or moderate COPD. Patients aged ≥40 years with a smoking history of at least 10 pack-year were included in the study. Primary endpoint was the rate of correct use of each device at the first day of treatment after reading the drug leaflet information and was evaluated under the supervision of a trained evaluator...
November 2018: Respiratory Medicine
Tu-Son Nguyen, Thi Lien Huong Nguyen, Thi Thuy Van Pham, Thi Bich Thao Cao, Van Khai Nguyen, Susan Hua, Shu Chuen Li
OBJECTIVE: Community pharmacists can make significant contributions and be an indispensable member in the asthma therapy chain. The present study aimed to investigate the current knowledge level of Vietnamese community pharmacists in asthma counselling and the impact of a short training program on asthma knowledge and practice. METHOD: 300 community pharmacists participated in the study. A knowledge questionnaire about asthma medications and a standardized inhaler checklist were designed to evaluate their knowledge before and after a 4-h training program...
November 2018: Respiratory Medicine
Clementine Nordon, Lamiae Grimaldi-Bensouda, Celine Pribil, Gaelle Nachbaur, Billy Amzal, Gabriel Thabut, Roger Marthan, Michel Aubier
OBJECTIVE: To describe the clinical and economic burden of severe asthma in France over 12 months. METHODS: Data were retrieved from the observational, prospective "Cohorte Obstruction Bronchique et Asthme" (COBRA) cohort, which has enrolled nearly 1000 asthma patients since 2007 from throughout France. Patients undergoing treatment with GINA step-4 or 5 medications uninterruptedly for 12 months (thus defining "severe asthma") were identified and their clinical data used to describe the clinical burden of asthma (exacerbations, symptoms outside exacerbations, and level of asthma control)...
November 2018: Respiratory Medicine
Kjell Torén, Martin Andersson, Anna-Carin Olin, Paul D Blanc, Bengt Järvholm
BACKGROUND: There is controversy as to whether airflow limitation should be defined as forced expiratory volume in 1 s (FEV1 )/vital capacity (VC) < 0.7 or as FEV1 /VC< the lower limit of normal (LLN). The aim was to examine whether different definitions of airflow limitation differ in predicting mortality. METHODS: Longitudinal prospective study of a national cohort of Swedish workers (199,408 men; 7988 women), aged 20-64 years with spirometry without bronchodilation at baseline followed from 1979 until death, or censorship at 2010...
November 2018: Respiratory Medicine
Sigurd Aarrestad, Magnus Qvarfort, Anne Louise Kleiven, Elin Tollefsen, Ole Henning Skjønsberg, Jean-Paul Janssens
OBJECTIVES: To evaluate the sensitivity and specificity of a screening test panel for nocturnal hypoventilation (NH) and other sleep related respiratory events during monitoring of patients with chronic hypercapnic respiratory failure (CRF) treated with NIV. METHODS: We performed a prospective study at Oslo University Hospital. Eligible for inclusion were consecutive adults with CRF due to neuromuscular diseases or chest wall disorders treated with NIV scheduled for a follow-up visit...
November 2018: Respiratory Medicine
Maria Jeppegaard, Sandra Veidal, Asger Sverrild, Vibeke Backer, Celeste Porsbjerg
BACKGROUND: The American Thoracic society (ATS) has suggested using fractional exhaled nitric oxide (FeNO) to monitor the level of eosinophilic (EOS) airway inflammation in asthma, but validation of the proposed cut-points is required in real-life populations. OBJECTIVE: To validate FeNO cut-points suggested by ATS in relation to sputum EOS count in a real life population of asthma patients. METHODS: All patients referred consecutively over a 12-months period for specialist assessment of asthma, were examined with FeNO and induced sputum, and re-examined 12 months later...
November 2018: Respiratory Medicine
Howraman Meteran, Simon Francis Thomsen, Martin R Miller, Jacob Hjelmborg, Torben Sigsgaard, Vibeke Backer
BACKGROUND: Although smoking is the major risk factor for chronic obstructive pulmonary disease (COPD) many patients with obstructive lung function suggesting COPD are never-smokers. Therefore, other lifestyle factors have been suggested as risk factors. AIMS: i) To examine the association between self-reported intake of fruit and vegetables and risk of COPD and ii) to examine whether the association between these traits are due to underlying genetic factors. METHODS: 12,449 twins, aged 40-80, from the Danish Twin Registry were recruited...
November 2018: Respiratory Medicine
Olorunfemi A Oshagbemi, Spencer J Keene, Johanna H M Driessen, Rachel Jordan, Emiel F M Wouters, Anthonius de Boer, Frank de Vries, Frits M E Franssen
INTRODUCTION: Exacerbations of chronic obstructive pulmonary disease are characterised by increased symptoms such as dyspnoea, cough and sputum production and/or purulence, leading to greater risk of hospitalisation and mortality. Very few studies have measured long term trends in the incidence of exacerbations of chronic obstructive pulmonary disease. We therefore investigated the incidence of moderate and severe exacerbations in the UK general population. METHODS: A population based-study including Clinical Practice Research Datalink (CPRD) patients ≥ 40 years of age with a current diagnosis of COPD within the United Kingdom from 2004 to 2013 was conducted...
November 2018: Respiratory Medicine
Claudio F Donner, Jonathan Raskin, Richard ZuWallack, Linda Nici, Nicolino Ambrosino, Bruno Balbi, Felicity Blackstock, Richard Casaburi, Michael Dreher, Tanja Effing, Roger Goldstein, Jerry Krishnan, Suzanne C Lareau, Barry J Make, Francois Maltais, Paula Meek, Michael Morgan, Jean-Louis Pépin, Chiara Rabbito, Carolyn L Rochester, Adam R Silverman, Sally Singh, Martijn A Spruit, Michele Vitacca, Loreen Williams
This report is a summary of a workshop focusing on using telemedicine to facilitate the integrated care of chronic obstructive pulmonary disease (COPD). Twenty-five invited participants from 8 countries met for one and one-half days in Stresa, Italy on 7-8 September 2017, to discuss this topic. Participants included physiotherapists, nurses, a nurse practitioner, and physicians. While evidence-based data are always at the center of sound inference and recommendations, at this point in time the science behind telemedicine in COPD remains under-developed; therefore, this document reflects expert opinion and consensus...
October 2018: Respiratory Medicine
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