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Respiratory Medicine

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https://www.readbyqxmd.com/read/29137908/no-evidence-found-for-an-association-between-prednisone-dose-and-fvc-change-in-newly-treated-pulmonary-sarcoidosis
#1
Caroline E Broos, Linda H C Poell, Caspar W N Looman, Johannes C C M In 't Veen, Marco J J H Grootenboers, Roxane Heller, Leon M van den Toorn, Monique Wapenaar, Henk C Hoogsteden, Mirjam Kool, Marlies S Wijsenbeek, Bernt van den Blink
BACKGROUND: Prednisone is used as first-line therapy for pulmonary sarcoidosis. What dosing strategy has the best balance between effect and side-effects is largely unknown. We analyzed change in forced vital capacity (FVC) and weight during different prednisone doses used in daily practice for treatment naïve pulmonary sarcoidosis patients. METHODS: Multilevel models were used to describe FVC and weight change over time. Correlations were calculated using linear regression models...
October 31, 2017: Respiratory Medicine
https://www.readbyqxmd.com/read/29102284/respiratory-medicine-focus-on-sarcoidosis-editor-s-welcome
#2
EDITORIAL
Marc A Judson
No abstract text is available yet for this article.
October 23, 2017: Respiratory Medicine
https://www.readbyqxmd.com/read/29055517/enhanced-cd8-cytolytic-t-cell-responses-in-the-peripheral-circulation-of-patients-with-sarcoidosis-and-non-l%C3%A3-fgren-s-disease
#3
Venkata Ramanarao Parasa, Helena Forsslund, Tobias Enger, Daniel Lorenz, Susanna Kullberg, Anders Eklund, Magnus Sköld, Jan Wahlström, Johan Grunewald, Susanna Brighenti
BACKGROUND: The role of CD4(+) T cells in the immunopathogenesis of pulmonary sarcoidosis is well-established, while less is known about the phenotype and function of CD8(+) cytolytic T cells (CTLs). METHODS: CD8(+) CTLs were explored in peripheral blood and bronchoalveolar lavage (BAL) samples obtained from up to 25 patients with sarcoidosis and 25 healthy controls. The proportion of CTLs was assessed by the expression of cytolytic effector molecules perforin, granzyme B and granulysin in CD8(+) T cells, using flow cytometry...
October 13, 2017: Respiratory Medicine
https://www.readbyqxmd.com/read/28919143/long-term-safety-of-glycopyrrolate-eflow-%C3%A2-cs-in-moderate-to-very-severe-copd-results-from-the-glycopyrrolate-for-obstructive-lung-disease-via-electronic-nebulizer-golden-5-randomized-study
#4
Gary T Ferguson, Thomas Goodin, Robert Tosiello, Alistair Wheeler, Edward Kerwin
BACKGROUND: The use of long-acting bronchodilators is an essential component of the management of chronic obstructive pulmonary disease (COPD). The GOLDEN 5 Phase III, randomized, active-controlled, open-label study was conducted to evaluate the long-term safety and tolerability of a nebulized glycopyrrolate formulation (SUN-101) delivered via the investigational eFlow(®) Closed System (eFlow(®) CS) nebulizer in subjects with moderate-to-very-severe COPD. METHODS: Subjects were randomized in a 4:3 ratio to nebulized glycopyrrolate 50 μg twice daily (BID) or tiotropium 18 μg once daily (OD) and treated for 48 weeks...
August 24, 2017: Respiratory Medicine
https://www.readbyqxmd.com/read/28947049/management-of-combined-pre-and-post-capillary-pulmonary-hypertension-in-advanced-heart-failure-with-reduced-ejection-fraction
#5
REVIEW
Sandeep Sahay, Ghaleb Khirfan, Adriano R Tonelli
Management of pulmonary hypertension (PH) has remained an unmet need in advanced left heart failure with reduced ejection fraction. In fact, patients are frequently denied heart transplant due to untreated pulmonary hypertension. The availability of mechanically circulatory devices and PH therapies has provided a ray of hope. PH specific therapies are currently not FDA approved for patients with left heart failure with reduced ejection fraction. However, clinicians have used these medications in anecdotal manner...
October 2017: Respiratory Medicine
https://www.readbyqxmd.com/read/28947048/association-of-lung-function-and-chronic-obstructive-pulmonary-disease-with-american-heart-association-s-life-s-simple-7-cardiovascular-health-metrics
#6
Wenjun Fan, Hwa Lee, Angela Lee, Chi Kieu, Nathan D Wong
BACKGROUND: Chronic obstructive pulmonary disease (COPD) is the third leading cause of death in the U.S. There is a strong association between COPD and cardiovascular (CV) disease; however, the relation between COPD and CV health factors is not well defined. We examined the relation between lung function and CV health factors defined by American Heart Association's (AHA) Life's Simple 7 (LS7). METHODS: We studied 6352 adults aged ≥20 from the National Health and Nutrition Examination Survey (NHANES) 2009-2012...
October 2017: Respiratory Medicine
https://www.readbyqxmd.com/read/28947047/gold-2017-treatment-pathways-in-real-life-an-analysis-of-the-daccord-observational-study
#7
Heinrich Worth, Roland Buhl, Carl-Peter Criée, Peter Kardos, Nadine S Lossi, Claus F Vogelmeier
INTRODUCTION: The 2017 update to the Global Initiative for Obstructive Lung Disease (GOLD) strategy document includes recommendations for treatment intensification or step-down in chronic obstructive pulmonary disease (COPD), although recognises that limited supporting information is available. DACCORD is an ongoing observational, non-interventional study, recruiting patients following COPD maintenance treatment change or initiation, a subset of whom were receiving a long-acting β2-agonist (LABA) plus a long-acting muscarinic antagonist (LAMA) fixed-dose combination (FDC) on entry...
October 2017: Respiratory Medicine
https://www.readbyqxmd.com/read/28947046/frailty-and-maximal-exercise-capacity-in-adult-lung-transplant-candidates
#8
Aimee M Layton, Hilary F Armstrong, Matthew R Baldwin, Anna J Podolanczuk, Nicole M Pieszchata, Jonathan P Singer, Selim M Arcasoy, Kimberly S Meza, Frank D'Ovidio, David J Lederer
BACKGROUND: Frail lung transplant candidates are more likely to be delisted or die without receiving a transplant. Further knowledge of what frailty represents in this population will assist in developing interventions to prevent frailty from developing. We set out to determine whether frail lung transplant candidates have reduced exercise capacity independent of disease severity and diagnosis. METHODS: Sixty-eight adult lung transplant candidates underwent cardiopulmonary exercise testing (CPET) and a frailty assessment (Fried's Frailty Phenotype (FFP))...
October 2017: Respiratory Medicine
https://www.readbyqxmd.com/read/28947045/the-complimentary-role-of-transbronchial-lung-cryobiopsy-and-endobronchial-ultrasound-fine-needle-aspiration-in-the-diagnosis-of-sarcoidosis
#9
Alejandro Adolfo Aragaki-Nakahodo, Robert P Baughman, Ralph T Shipley, Sadia Benzaquen
PURPOSE: Transbronchial lung cryobiopsy (TBLC) is a novel technique that has proved to be useful in diagnosing various interstitial lung diseases (ILD). The use of TBLC to diagnose sarcoidosis in an unselected patient population is unknown, and could be complimentary to endobronchial ultrasound fine needle aspiration (EBUS-FNA). METHODS: A retrospective analysis of 36 patients in a single, tertiary-care, academic medical center was conducted to describe the yield of both EBUS-FNA and TBLC in the diagnosis of suspected sarcoidosis over a three year period...
October 2017: Respiratory Medicine
https://www.readbyqxmd.com/read/28947044/sex-and-racial-ethnic-differences-in-the-reason-for-30-day-readmission-after-copd-hospitalization
#10
Tadahiro Goto, Mohammad Kamal Faridi, Koichiro Gibo, Carlos A Camargo, Kohei Hasegawa
BACKGROUND: Reduction of 30-day readmissions in patients hospitalized for chronic obstructive pulmonary disease (COPD) is a national objective. However, there is a dearth of research on sex and racial/ethnic differences in the reason for 30-day readmission. METHODS: We conducted a retrospective cohort study using 2006-2012 data from the State Inpatient Database of eight geographically-diverse US states (Arkansas, California, Florida, Iowa, Nebraska, New York, Utah, and Washington)...
October 2017: Respiratory Medicine
https://www.readbyqxmd.com/read/28947043/does-high-flow-nasal-cannula-oxygen-improve-outcome-in-acute-hypoxemic-respiratory-failure-a-systematic-review-and-meta-analysis
#11
REVIEW
Si-Ming Lin, Kai-Xiong Liu, Zhi-Hong Lin, Pei-Hong Lin
INTRODUCTION: To evaluate the efficacy of high-flow nasal cannula (HFNC) in the rate of intubation and mortality for patients with acute hypoxemic respiratory failure. METHODS: We searched Pubmed, EMBASE, and the Cochrane Library for relevant studies. Two reviewers extracted data and reviewed the quality of the studies independently. The primary outcome was the rate of intubation; secondary outcome was mortality in the hospital. Study-level data were pooled using a random-effects model when I2 was >50% or a fixed-effects model when I2 was <50%...
October 2017: Respiratory Medicine
https://www.readbyqxmd.com/read/28947042/therapeutic-targets-in-idiopathic-pulmonary-fibrosis
#12
REVIEW
Martin Kolb, Francesco Bonella, Lutz Wollin
Idiopathic pulmonary fibrosis (IPF) is a progressive and ultimately fatal interstitial lung disease. After many drugs failed in clinical trials, improvements in the understanding of the pathogenesis of IPF led to the approval of two drugs that slow the progression of the disease. However, the prognosis for patients with IPF remains poor and the search continues for drugs that inhibit the pathogenic pathways active in IPF to reduce or even halt the progression of the disease. In this article, we review the mechanisms of action of the two approved therapies for IPF (nintedanib and pirfenidone) and of the investigational compounds that are in Phase II trials and discuss the potential for combination therapy in the treatment of IPF...
October 2017: Respiratory Medicine
https://www.readbyqxmd.com/read/28947041/treatment-outcomes-of-rifampin-sparing-treatment-in-patients-with-pulmonary-tuberculosis-with-rifampin-mono-resistance-or-rifampin-adverse-events-a-retrospective-cohort-analysis
#13
Shinhee Park, Kyung-Wook Jo, Sang Do Lee, Woo Sung Kim, Tae Sun Shim
BACKGROUND: Rifampin (RIF) mono-resistant tuberculosis (RMR-TB) is a rare disease. Current guidelines recommend that RMR-TB be treated as multidrug-resistant TB (MDR-TB) but the evidence is scarce. METHODS: We conducted a retrospective cohort study on pulmonary TB patients to investigate the characteristics and outcomes of RMR-TB. The characteristics of RMR-TB were compared with those with adverse events to rifampin (RAE-TB). RESULTS: Forty-four RMR-TB and 29 RAE-TB patients were enrolled...
October 2017: Respiratory Medicine
https://www.readbyqxmd.com/read/28947040/comparison-of-titrable-thermoplastic-versus-custom-made-mandibular-advancement-device-for-the-treatment-of-obstructive-sleep-apnoea
#14
Frédéric Gagnadoux, Xuan-Lan Nguyen, Marc Le Vaillant, Pascaline Priou, Nicole Meslier, Audrey Eberlein, Jean-Daniel Kun-Darbois, Cyril Chaufton, Bruno Villiers, Maguy Levy, Wojciech Trzépizur, Sandrine Launois
BACKGOUND AND OBJECTIVES: The disadvantages of custom-made mandibular advancement devices (MAD) for obstructive sleep apnoea (OSA) therapy are the cost and delay required to manufacture the device. This study aimed to evaluate the efficacy of a titrable, thermoplastic MAD compared to a custom-made MAD for OSA therapy. METHODS: In this prospective nonrandomized study, 158 patients with OSA from two French sleep centers were treated for 6 months with a titrable thermoplastic MAD (n = 86) or a custom-made MAD (n = 72)...
October 2017: Respiratory Medicine
https://www.readbyqxmd.com/read/28947039/pneumonia-risk-with-inhaled-fluticasone-furoate-and-vilanterol-in-copd-patients-with-moderate-airflow-limitation-the-summit-trial
#15
Courtney Crim, Peter M A Calverley, Julie A Anderson, Andrew P Holmes, Sally Kilbride, Fernando J Martinez, Robert D Brook, David E Newby, Julie C Yates, Bartolomé R Celli, Jørgen Vestbo
RATIONALE: Pneumonia risk with inhaled corticosteroid use in chronic obstructive pulmonary disease (COPD) has not been thoroughly assessed in patients with moderate airflow limitation. OBJECTIVES: To determine the incidence of pneumonia and risk factors in COPD patients with moderate airflow limitation who had, or were at high risk for cardiovascular disease. METHODS: In the Study to Understand Mortality and MorbidITy in COPD (SUMMIT), 16,590 subjects with moderate airflow limitation (50% ≤ FEV1 ≤ 70% predicted) and heightened cardiovascular risk were randomized double-blind 1:1:1:1 to inhaled once-daily vilanterol 25 μg (VI), fluticasone furoate 100 μg (FF), vilanterol 25 μg combined with 100 μg fluticasone furoate (FF/VI), or matched placebo...
October 2017: Respiratory Medicine
https://www.readbyqxmd.com/read/28947038/clinical-impact-of-pseudomonas-aeruginosa-colonization-in-patients-with-primary-ciliary-dyskinesia
#16
Malena Cohen-Cymberknoh, Nir Weigert, Alex Gileles-Hillel, Oded Breuer, Natalia Simanovsky, Mieke Boon, Kris De Boeck, Angelo Barbato, Deborah Snijders, Mirella Collura, Ugo Pradal, Hannah Blau, Huda Mussaffi, Mareike Price, Lea Bentur, Michal Gur, Micha Aviram, Elie Picard, Michal Shteinberg, Galit Livnat, Joseph Rivlin, Nurith Hiller, David Shoseyov, Israel Amirav, Eitan Kerem
BACKGROUND: Airway infections in Primary Ciliary Dyskinesia (PCD) are caused by different microorganisms, including pseudomonas aeruginosa (PA). The aim of this study was to investigate the association of PA colonization and the progression of lung disease in PCD. METHODS: Data from 11PCD centers were retrospectively collected from 2008 to 2013. Patients were considered colonized if PA grew on at least two separate sputum cultures; otherwise, they were classified as non-colonized...
October 2017: Respiratory Medicine
https://www.readbyqxmd.com/read/28947037/physicians-preference-for-controller-medication-in-mild-persistent-asthma
#17
Arzu Bakirtas, Ali Kutlu, Ayse Baccioglu, Ferda Oner Erkekol, Sevim Bavbek, Omer Kalayci
BACKGROUND: Although the asthma guidelines recommend inhaled corticosteroids(ICS) or leukotriene receptor antagonists-(LTRAs) for the treatment of mild persistent asthma, factors governing the physicians' preference are unknown. We aimed to investigate the preference of physicians for the controller medication and the factors governing their choice. METHODS: A self-administered questionnaire composed of 16 questions that aimed to determine the preference of the physicians for the first choice controller medication in mild persistent asthma and physician and patient related factors that may be associated with this selection was e-mailed to the members of the Turkish National Society of Allergy and Clinical Immunology and distributed to participants in the 21st congress...
October 2017: Respiratory Medicine
https://www.readbyqxmd.com/read/28947036/possible-uip-pattern-on-high-resolution-computed-tomography-is-associated-with-better-survival-than-definite-uip-in-ipf-patients
#18
Margaret L Salisbury, Leslie B Tolle, Meng Xia, Susan Murray, Nabihah Tayob, Anoop M Nambiar, Shelley L Schmidt, Amir Lagstein, Jeffery L Myers, Barry H Gross, Ella A Kazerooni, Baskaran Sundaram, Aamer R Chughtai, Fernando J Martinez, Kevin R Flaherty
BACKGROUND: Idiopathic pulmonary fibrosis (IPF) is a progressive fibrosing lung disease of unknown etiology. Inter-society consensus guidelines on IPF diagnosis and management outline radiologic patterns including definite usual interstitial pneumonia (UIP), possible UIP, and inconsistent with UIP. We evaluate these diagnostic categories as prognostic markers among patients with IPF. METHODS: Included subjects had biopsy-proven UIP, a multidisciplinary team diagnosis of IPF, and a baseline high-resolution computed tomography (HRCT)...
October 2017: Respiratory Medicine
https://www.readbyqxmd.com/read/28947035/ivacaftor-for-the-p-ser549arg-s549r-gating-mutation-the-israeli-experience
#19
Adi Dagan, Malena Cohen-Cymberknoh, Michal Shteinberg, Hagit Levine, Daphna Vilozni, Yael Bezalel, Bat-El Bar Aluma, Ifat Sarouk, Moshe Ashkenazi, Moran Lavie, Reuven Tsabari, Hannah Blau, Eitan Kerem, Lea Bentur, Ori Efrati, Galit Livnat
BACKGROUND: Ivacaftor is a drug that increases the probability of the cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel remaining open. Information about the efficacy of ivacaftor in patients carrying the rare p.Ser549Arg (S549R) CFTR mutation is sparse. AIM: Efficacy of ivacaftor treatment in patients carrying the p.Ser549Arg (S549R) CFTR mutation. METHODS: Data obtained from CF patients receiving ivacaftor for one year...
October 2017: Respiratory Medicine
https://www.readbyqxmd.com/read/28947034/treatment-and-outcome-of-non-tuberculous-mycobacterial-pulmonary-disease-in-a-predominantly-fibro-cavitary-disease-cohort
#20
Sanne Zweijpfenning, Stephan Kops, Cecile Magis-Escurra, Martin J Boeree, Jakko van Ingen, Wouter Hoefsloot
BACKGROUND: The incidence of non-tuberculous mycobacterial pulmonary disease (NTM-PD) has increased in the Netherlands. The fibro-cavitary disease manifestation predominates, as elsewhere in Europe. We studied treatment and outcome of this disease manifestation, as such data are scarce. METHODS: We conducted a retrospective study of all patients diagnosed with NTM-PD according to the American Thoracic Society statement between 2008 and 2013 in a reference clinic...
October 2017: Respiratory Medicine
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