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Respiratory Medicine

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https://www.readbyqxmd.com/read/27916482/-evaluation-of-chronic-obstructive-pulmonary-disease-copd-and-reduced-ejection-fraction-heart-failure-hfref-discharge-medication-prescribing-is-drug-therapy-concordant-with-national-guidelines-associated-with-a-reduction-in-30-day-readmissions-respir-med-119
#1
Amy Richardson, Elizabeth Tolley, Jonathan Hartmann, Jasmine Reedus, Brandi Bowlin, Christopher Finch, Christopher W Sands, Timothy Self
No abstract text is available yet for this article.
December 1, 2016: Respiratory Medicine
https://www.readbyqxmd.com/read/27916481/reference-values-for-forced-vital-capacity-in-idiopathic-pulmonary-fibrosis
#2
LETTER
Carlos Ac Pereira
No abstract text is available yet for this article.
November 28, 2016: Respiratory Medicine
https://www.readbyqxmd.com/read/27890470/sgc-stimulators-evidence-for-riociguat-beyond-groups-1-and-4-pulmonary-hypertension
#3
Raymond Benza, Stephen Mathai, Steven D Nathan
Pulmonary hypertension (PH) is a chronic cardiopulmonary disorder that if left untreated, progresses rapidly and is ultimately fatal. The World Health Organization (WHO) has classified PH into 5 distinct groups according to pathophysiology, hemodynamic characteristics, and clinical presentation. Dysfunction in the nitric oxide (NO) pathway plays a key role in the pulmonary hypertension disease process, including in WHO Groups 2 and 3 PH. PH is associated with endothelial dysfunction, impaired synthesis of NO, and insufficient stimulation of the NO-soluble guanylate cyclase (sGC)-cyclic guanosine monophosphate (cGMP) pathway, which reduces cGMP production...
November 14, 2016: Respiratory Medicine
https://www.readbyqxmd.com/read/27887774/rationale-and-study-design-of-respite-an-open-label-phase-3b-study-of-riociguat-in-patients-with-pulmonary-arterial-hypertension-who-demonstrate-an-insufficient-response-to-treatment-with-phosphodiesterase-5-inhibitors
#4
Marius M Hoeper, James R Klinger, Raymond L Benza, Gerald Simonneau, David Langleben, Robert Naeije, Paul A Corris
Patients with pulmonary arterial hypertension (PAH) who do not have an adequate response to therapy with phosphodiesterase-5 inhibitors (PDE-5i) may have insufficient synthesis of cyclic guanosine monophosphate (cGMP). These patients may respond to a direct soluble guanylate cyclase (sGC) stimulator such as riociguat. RESPITE (NCT02007629) was an open-label, multicenter, uncontrolled, single-arm phase 3b study of riociguat in patients with PAH who demonstrated an insufficient response to treatment with PDE-5i...
November 5, 2016: Respiratory Medicine
https://www.readbyqxmd.com/read/27884593/idiopathic-interstitial-pneumonia-associated-pulmonary-hypertension-a-target-for-therapy
#5
Steven D Nathan, Jürgen Behr, Vincent Cottin, Harold R Collard, Marius M Hoeper, Fernando J Martinez, Athol U Wells
Advances in the treatment of idiopathic interstitial pneumonia (IIP) represent an urgent, unmet medical need for patients with this category of diffuse parenchymal lung disease. IIPs involve varying combinations of fibrosis and inflammation of unknown cause and may be associated with pulmonary hypertension (PH). When it occurs, PH is associated with higher oxygen needs, greater functional impairment, and increased mortality. However, whether or when PH is a maladaptive versus adaptive phenomenon remains to be determined...
November 5, 2016: Respiratory Medicine
https://www.readbyqxmd.com/read/27890471/rationale-and-study-design-of-motion-a-phase-4-prospective-single-arm-open-label-study-to-measure-outcomes-in-patients-with-pulmonary-arterial-hypertension-not-on-active-treatment
#6
Stephen C Mathai, Omar Minai, Sean D Sullivan, Debra Lerner, Deborah Levine
In clinical trials of treatments for pulmonary arterial hypertension (PAH), objective measures, such as 6-min walking distance (6MWD) are limited in their ability to characterize the impact of PAH therapy from a patient's perspective. Few clinical studies have evaluated the primary effects of pharmacologic treatment on patient-reported outcomes, such as symptoms, health-related quality of life (HRQoL), and productivity. MOTION (NCT02191137) is a prospective, multicenter, single-arm, open-label, phase 4 trial designed to assess whether riociguat monotherapy will improve patient-reported outcomes in patients with PAH in the United States who are not currently on treatment...
November 2, 2016: Respiratory Medicine
https://www.readbyqxmd.com/read/27993295/viruses-are-prevalent-in-non-ventilated-hospital-acquired-pneumonia
#7
Andrew F Shorr, Marya D Zilberberg, Scott T Micek, Marin H Kollef
BACKGROUND: Hospital-acquired pneumonia arising in non-ventilated patients (NVHAP) is traditionally thought to be caused by bacteria, and little is known about viral etiologies in this syndrome. We sought to describe the prevalence of viruses causing NVHAP and to determine factors independently associated with the isolation of a virus. METHODS: We identified patients with NVHAP over one year and reviewed their cultures to determine etiologies. Patients with a viral process were compared to those with either negative cultures or a bacterial infection to determine variables independently associated with the recovery of a virus...
January 2017: Respiratory Medicine
https://www.readbyqxmd.com/read/27993294/the-effect-of-habitual-waterpipe-tobacco-smoking-on-pulmonary-function-and-exercise-capacity-in-young-healthy-males-a-pilot-study
#8
F I Hawari, N A Obeidat, I M Ghonimat, H S Ayub, S S Dawahreh
BACKGROUND: Evidence regarding the health effects of habitual waterpipe smoking is limited, particularly in young smokers. Respiratory health and cardiopulmonary exercise tests were compared in young male habitual waterpipe smokers (WPS) versus non-smokers. METHODS: 69 WPS (≥3 times/week for three years) and 69 non-smokers were studied. Respiratory health was assessed through the American Thoracic Society and the Division of Lung Diseases (ATS-DLD-78) adult questionnaire...
January 2017: Respiratory Medicine
https://www.readbyqxmd.com/read/27993293/effect-of-psychological-and-other-factors-on-quality-of-life-amongst-asthma-outpatients-in-lagos-nigeria
#9
Olufunke O Adeyeye, Tomilola A Adewumi, Abiodun O Adewuya
BACKGROUND: This study aimed to assess the effect of psychological and other possible factors associated with poor health related quality of life (HRQOL) in outpatient with asthma in Lagos, Nigeria. METHODS: Patients (n  = 201) recruited from the adult asthma outpatient clinic were assessed for sociodemographic and asthma related variables. Levels of social support (with Oslo 3-Item Social Support Scale), disability (with WHO Disability Assessment Scale) were assessed...
January 2017: Respiratory Medicine
https://www.readbyqxmd.com/read/27993292/long-term-general-and-cardiovascular-safety-of-tiotropium-olodaterol-in-patients-with-moderate-to-very-severe-chronic-obstructive-pulmonary-disease
#10
Roland Buhl, Sheldon Magder, Ulrich Bothner, Kay Tetzlaff, Florian Voß, Lazaro Loaiza, Claus F Vogelmeier, Lorcan McGarvey
BACKGROUND: Long-term safety, particularly cardiovascular safety, is of special interest in maintenance treatment of chronic obstructive pulmonary disease (COPD) with long-acting β2-agonists and long-acting muscarinic antagonists, given potential cardiovascular effects. METHODS: Two 52-week Phase III trials (TONADO(®)) investigated tiotropium/olodaterol (5/5 and 2.5/5 μg) versus tiotropium 2.5, 5 μg and olodaterol 5 μg. In a pre-specified safety analysis, investigator-reported treatment-emergent adverse events (AEs), electrocardiogram and laboratory data were pooled...
January 2017: Respiratory Medicine
https://www.readbyqxmd.com/read/27993291/validation-of-asthma-control-questionnaire-and-risk-factors-affecting-uncontrolled-asthma-among-the-lebanese-children-s-population
#11
Souheil Hallit, Chantal Raherison, Mirna Waked, Pascale Salameh
OBJECTIVES: To validate the Arabic version of the Asthma Control Test (ACT) in asthmatic children in Lebanon and identify risk factors that might affect asthma control in these children. METHODS: This study, conducted between December 2015 and April 2016, included 300 children. RESULTS: A high Cronbach's alpha was found for the full scale (0.959). The correlation factors between each item of the ACT scale and the whole scale ranged between 0...
January 2017: Respiratory Medicine
https://www.readbyqxmd.com/read/27993290/increased-levels-of-prostaglandin-e-major-urinary-metabolite-pge-mum-in-chronic-fibrosing-interstitial-pneumonia
#12
Tsugumi Horikiri, Hiromichi Hara, Nayuta Saito, Jun Araya, Naoki Takasaka, Hirofumi Utsumi, Haruhiko Yanagisawa, Mitsuo Hashimoto, Yutaka Yoshii, Hiroshi Wakui, Shunsuke Minagawa, Takeo Ishikawa, Kenichiro Shimizu, Takanori Numata, Seiji Arihiro, Yumi Kaneko, Katsutoshi Nakayama, Tomokazu Matsuura, Masaaki Matsuura, Mutsunori Fujiwara, Isao Okayasu, Satoru Ito, Kazuyoshi Kuwano
BACKGROUND: Dysregulation of the prostaglandin E2 (PGE2) signaling pathway has been implicated in interstitial pneumonia (IP) pathogenesis. Due to the unstable nature of PGE2, available detection methods may not precisely reflect PGE2 levels. We explored the clinical usefulness of measuring stable prostaglandin E-major urinary metabolite (PGE-MUM) with respect to pathogenesis and extent of chronic fibrosing IP (CFIP), including idiopathic pulmonary fibrosis (IPF), as PGE-MUM is reflective of systemic PGE2 production...
January 2017: Respiratory Medicine
https://www.readbyqxmd.com/read/27993289/beneficial-effects-of-omalizumab-therapy-in-allergic-bronchopulmonary-aspergillosis-a-synthesis-review-of-published-literature
#13
REVIEW
Jian-Xiong Li, Li-Chao Fan, Man-Hui Li, Wei-Jun Cao, Jin-Fu Xu
Omalizumab, a humanized mAb that binds to IgE, has been an effective therapy for patients with severe allergic asthma; however, there are few clinical trials examining the efficacy of Omalizumab in patients with allergic bronchopulmonary aspergillosis (ABPA) except some case reports. To assess the clinical and immunological effects of Omalizumab in ABPA patients, we made a synthesis review of 102 cases from 30 published literature, analyzed the effects of Omalizumab therapy in ABPA and conducted subgroup analyses to determine factors that influenced the therapy endpoints...
January 2017: Respiratory Medicine
https://www.readbyqxmd.com/read/27993288/diagnosis-of-complicated-parapneumonic-effusion-by-pleural-ph-measurement-is-jeopardized-by-inadequate-physician-knowledge-and-guideline-discordant-laboratory-practice
#14
Lauren Ng, Eli Dabscheck, Mark Hew
Pleural fluid pH is a crucial determinant of complicated parapneumonic effusion diagnosis and the need for drainage. It is best measured by blood gas analyzer. We examined whether physicians were aware of this, and whether their laboratories measured pleural pH according to their expectations. Only 53% of physicians understood the need for blood gas analyzer measurements, only 50% of laboratories used blood gas analyzers, and only 35% of physicians correctly identified the method performed in their laboratory...
January 2017: Respiratory Medicine
https://www.readbyqxmd.com/read/27993287/addition-of-vitamin-b12-to-exercise-training-improves-cycle-ergometer-endurance-in-advanced-copd-patients-a-randomized-and-controlled-study
#15
Fernanda Viana Paulin, Alessandro Moura Zagatto, Gaspar R Chiappa, Paulo de Tarso Müller
Vitamin B12 is essential in the homocysteine, mitochondrial, muscle and hematopoietic metabolisms, and its effects on exercise tolerance and kinetics adjustments of oxygen consumption (V'O2p) in rest-to-exercise transition in COPD patients are unknown. This randomized, double-blind, controlled study aimed to verify a possible interaction between vitamin B12 supplementation and these outcomes. After recruiting 69 patients, 35 subjects with moderate-to-severe COPD were eligible and 32 patients concluded the study, divided into four groups (n = 8 for each group): 1...
January 2017: Respiratory Medicine
https://www.readbyqxmd.com/read/27993286/pulse-transit-time-changes-in-subjects-exhibiting-sleep-disordered-breathing
#16
Biswajit Chakrabarti, Stephen Emegbo, Sonya Craig, Nick Duffy, John O'Reilly
INTRODUCTION: Pulse Transit Time (PTT) represents a non-invasive marker of sleep fragmentation in OSAS. Little is known regarding PTT in sleepy subjects exhibiting nocturnal Inspiratory Flow Limitation (IFL) in the absence of apneas or desaturation. MATERIALS AND METHODS: The IFL cohort was gender and age matched to subjects with OSAS and a cohort where Sleep Disordered Breathing (SBD)/IFL was absent ("Non Flow Limited" or NFL cohort); PTT Arousal index (PTT Ar) defined by number of PTT arousals per hour...
January 2017: Respiratory Medicine
https://www.readbyqxmd.com/read/27993285/analysis-of-discrepant-results-between-the-genotype-%C3%A2-mtbdrplus-assay-and-an-antimicrobial-drug-susceptibility-test-for-isoniazid-resistant-tuberculosis
#17
Kyung-Wook Jo, Yoomi Yeo, Heungsup Sung, Mi-Na Kim, Tae Sun Shim
BACKGROUND: We investigated discrepant results determined using the Genotype(®)MTBDRplus assay and a conventional antimicrobial drug susceptibility test (ADST) for isoniazid (INH) resistance using sequencing analysis and analyzed the clinical course of patients with discrepant results. METHODS: Among 1373 MTBDRplus assays performed at our tertiary referral center in South Korea between August 2009 and December 2015, the results for 46 (3.4%) differed from those for ADST...
January 2017: Respiratory Medicine
https://www.readbyqxmd.com/read/27993284/non-persistence-and-non-adherence-to-long-acting-copd-medication-therapy-a-retrospective-cohort-study-based-on-a-large-german-claims-dataset
#18
Sabrina Mueller, Thomas Wilke, Benno Bechtel, Yogesh Suresh Punekar, Karen Mitzner, J Christian Virchow
OBJECTIVES: The main objectives of this study, based on a large cohort of German COPD patients, were to assess the level of non-persistence (NP) and non-adherence (NA) with long-acting COPD inhaler treatment and to describe factors that may be associated with NP and NA. METHODS: This was a retrospective cohort analysis based on claims data provided by a German statutory health insurance fund (years 2010-2012). NP was analyzed for treatment-naïve patients only; it was defined as a gap of >90 days in medication availability...
January 2017: Respiratory Medicine
https://www.readbyqxmd.com/read/27888997/comprehensive-assessment-of-myositis-specific-autoantibodies-in-polymyositis-dermatomyositis-associated-interstitial-lung-disease
#19
Hironao Hozumi, Tomoyuki Fujisawa, Ran Nakashima, Takeshi Johkoh, Hiromitsu Sumikawa, Akihiro Murakami, Noriyuki Enomoto, Naoki Inui, Yutaro Nakamura, Yuji Hosono, Yoshitaka Imura, Tsuneyo Mimori, Takafumi Suda
OBJECTIVES: Myositis-specific autoantibodies (MSAs) are associated with clinical phenotypes in polymyositis/dermatomyositis (PM/DM). No study has investigated the clinical features based on comprehensive MSA assessment in PM/DM-associated interstitial lung disease (ILD). We aimed to determine the practical significance of MSAs in PM/DM-ILD. METHODS: Sixty consecutive PM/DM-ILD patients were retrospectively analysed. Serum MSAs were comprehensively measured using immunoprecipitation assay...
December 2016: Respiratory Medicine
https://www.readbyqxmd.com/read/27888996/the-effects-of-chronic-obstructive-pulmonary-disease-self-management-interventions-on-improvement-of-quality-of-life-in-copd-patients-a-meta-analysis
#20
REVIEW
Danielle Cannon, Nicholas Buys, Krishna Bajee Sriram, Siddharth Sharma, Norman Morris, Jing Sun
This article aimed to analyse the outcome of self-management randomised control trials and their impact upon chronic obstructive pulmonary disease patients' health outcomes using meta-analysis approach. PubMed, Scopus, CINAHL, Web of Science databases and Cochrane Library, were searched for articles between 1990 and December 2015 by two researchers. Self-management programs significantly improved patients' quality of life across all domains of the St George Respiratory Questionnaire (SGRQ) (activity -2.21 (95% CI: -3...
December 2016: Respiratory Medicine
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