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Respiratory Medicine

Bridget F Collins, Robyn L McClelland, Lawrence A Ho, Carmen R Mikacenic, Jennifer Hayes, Carolyn Spada, Ganesh Raghu
BACKGROUND: Idiopathic Pulmonary Fibrosis (IPF) and Sarcoidosis are distinct clinical entities. Fibrotic disease in pulmonary sarcoidosis is typically upper lobe predominant. In IPF fibrosis is basilar and peripheral predominant [usual interstitial pneumonia (UIP) pattern]. Sarcoidosis and UIP have rarely been observed in the same patient. We sought to characterize patients manifesting both sarcoidosis and IPF and compare clinical features and survival to that of patients with "Lone-IPF" (IPF only) and pulmonary sarcoidosis with fibrosis in a non-UIP pattern...
August 23, 2018: Respiratory Medicine
John R Bach, Susan B Liu, Nikhil Potpally, Yuka Ishikawa, Miguel R Gonçalves
No abstract text is available yet for this article.
August 22, 2018: Respiratory Medicine
Marc A Judson
No abstract text is available yet for this article.
July 26, 2018: Respiratory Medicine
Pia Hardelid, Melpo Kapetanstrataki, Lee Norman, Sarah J Fleming, Paula Lister, Ruth Gilbert, Roger C Parslow
No abstract text is available yet for this article.
September 2018: Respiratory Medicine
Elisabet Nerpin, Tiago Jacinto, João A Fonseca, Kjell Alving, Christer Janson, Andrei Malinovschi
BACKGROUND: Low-grade systemic inflammation, mainly assessed by C-reactive protein (CRP), has been associated with impaired lung function. Few studies have studied if CRP, blood eosinophils, and blood neutrophils offer additive information in relation to lung function. OBJECTIVES: To analyse associations between lung function and CRP, blood eosinophils, and blood neutrophils, with special regard to additive information of combining the inflammatory markers. METHODS: Cross-sectional study on 7753 participants, 20-80 years of age, in the National Health and Nutrition Examination Survey...
September 2018: Respiratory Medicine
Fernando De Benedetto, Roberta Pastorelli, Manuela Ferrario, Francesca de Blasio, Stefano Marinari, Laura Brunelli, Emiel F M Wouters, Francesca Polverino, Bartolome R Celli
BACKGROUND: Skeletal muscle dysfunction and poor functional capacity are important extra-pulmonary manifestations of chronic obstructive pulmonary disease (COPD), especially in COPD patients on long-term O2 therapy (LTOT). Beside the role of pulmonary rehabilitation, the effect of nutritional interventions is still controversial, and there are knowledge gaps on the effective role of nutraceutical supplementation on hard endpoints. The aim of this study was to investigate the effects of nutritional supplementation with Coenzyme Q10 (QTer® ) - a powerful antioxidant with the potential to reduce oxidative stress and improve mitochondrial function - and Creatine on functional, nutritional, and metabolomic profile in COPD patients on long-term O2 therapy...
September 2018: Respiratory Medicine
Joan B Soriano, Michael Hahsler, Cecilia Soriano, Cristina Martinez, Juan P de-Torres, Jose M Marín, Pilar de Lucas, Borja G Cosio, Antònia Fuster, Ciro Casanova
BACKGROUND: The stability of the new GOLD 2017 COPD staging is unknown, as well as the frequency of individual transitions in COPD stages beyond one year. METHODS: All COPD participants in the CHAIN cohort were re-analysed according to GOLD 2017 up to five years of follow-up. Their individual changes within COPD stages were aggregated into cohort-wide Markov chains; group stability was evaluated using joinpoint regression. RESULTS: At baseline, 959 COPD patients were distributed according to GOLD 2017 stages as 37...
September 2018: Respiratory Medicine
Michael Bogart, Richard H Stanford, Tyler Reinsch, Michael Hull, Ami Buikema, Erin Hulbert
BACKGROUND: This study assessed patient-level characteristics and patterns of medication use in patients with chronic obstructive pulmonary disease (COPD) before initiation of multiple inhaler triple therapy (MITT; long-acting muscarinic antagonist/long-acting β2 -agonist/inhaled corticosteroid [ICS/LAMA/LABA] combination). METHODS: This retrospective study was conducted using the Optum Research Database. Patients enrolled in commercial or Medicare Advantage Prescription Drug plans, with a COPD diagnosis and >1 prescription for a COPD medication between January 2014 and March 2016 were included...
September 2018: Respiratory Medicine
Rasa Ruseckaite, Natalie Pekin, Susannah King, Erin Carr, Susannah Ahern, John Oldroyd, Arul Earnest, Claire Wainwright, David Armstrong
OBJECTIVES: To determine the association between the implementation of the 2006 Australasian Clinical Practice Guidelines for Nutrition in Cystic Fibrosis (CF) and the nutritional status of children participating in the Australian Cystic Fibrosis Data Registry (ACFDR). METHODS: This research consisted of a quantitative study using ACFDR data and a survey of clinicians and dietitians treating children with CF. Two independent cohorts of children (2-5 years and 6-11 years) were selected from ACFDR between 1998 and 2014 (N = 2304)...
September 2018: Respiratory Medicine
Alvise Berti, Gerald W Volcheck, Divi Cornec, Robert J Smyth, Ulrich Specks, Karina A Keogh
BACKGROUND: Although asthma, rhinitis/rhinosinusitis and peripheral eosinophilia are present in virtually all patients with eosinophilic granulomatosis with polyangiitis (EGPA), the role of atopy in these patients is not well defined. OBJECTIVE: To clarify the role of atopy in patients affected with EGPA. METHODS: Clinical, laboratory and standard spirometry data have been abstracted from medical records. Only patients who underwent skin and/or specific IgE testing for common aeroallergens before the vasculitic phase were included...
September 2018: Respiratory Medicine
Niovi Papalexopoulou, Theodore G Dassios, Alan Lunt, Fiona Bartlett, Felicity Perrin, Cara J Bossley, Hilary A Wyatt, Anne Greenough
BACKGROUND: Nutrition is closely related to mortality and pulmonary and respiratory muscle function in cystic fibrosis (CF) patients. We initially validated results from a bioelectrical impedance device against dual energy x-ray absorptiometry (DEXA). We then determined whether fat free mass assessed by a portable impedance device rather than body mass index (BMI) better correlated with pulmonary function, respiratory muscle strength and exercise capacity in CF patients. METHODS: Eighteen young people and adults (median age 19, range 12-39 years) with CF had dual energy X-ray absorptiometry and direct segmental multi-frequency impedance analysis...
September 2018: Respiratory Medicine
Federica De Giacomi, Darin White, Christian W Cox, Teng Moua
BACKGROUND: Whether current diagnostic computed tomography (CT) patterns in idiopathic pulmonary fibrosis (IPF) represent distinct clinical phenotypes or simply temporal evolution of the same underlying radiologic process is unknown. We studied IPF patients presenting with 'possible' or 'inconsistent' usual interstitial pneumonia (UIP) CT patterns and characterized the frequency and timing of evolution to 'consistent' UIP and its effect on survival. MATERIAL AND METHODS: Consecutive IPF patients seen at our institution from 1/1/2005 through 12/31/2013 were assessed for study inclusion...
September 2018: Respiratory Medicine
Enrico Heffler, Claudia Crimi, Salvatore Mancuso, Raffaele Campisi, Francesca Puggioni, Luisa Brussino, Nunzio Crimi
BACKGROUND: The diagnosis of both asthma and chronic obstructive pulmonary disease (COPD) consists of a combination of classical symptoms and signs, and the evidence of consistent lung function abnormalities. Spiromety has been reported to be underused, possibly for practical difficulties in accessing to a lung function lab. This may lead to misdiagnosis of both asthma and COPD. We aimed to evaluate the frequency of spirometry use and the concordance between doctor-diagnosed asthma and COPD and spirometric patterns, in an unselected cohort of patients sent by general practitioners to perform a spirometry...
September 2018: Respiratory Medicine
Anouk W Vaes, Martijn A Spruit, Jan Theunis, Emiel F M Wouters, Patrick De Boever
BACKGROUND: Patients with COPD are frequently diagnosed with cardiovascular disease. Peripheral endothelial dysfunction is an underlying mechanism and can be used as an early marker of cardiovascular impairment. To date, little is known on the association between peripheral endothelial dysfunction, cardiovascular risk factors and measurements of exercise capacity in patients with COPD. Therefore, we aimed to determine the relation between endothelial function and patient characteristics, cardiovascular risk factors and (micro)vascular and functional performance in patient with CODP...
September 2018: Respiratory Medicine
Rodrigo Cavallazzi, Anna Jorayeva, Bryan L Beatty, Demetra Antimisiaris, Rangaraj Gopalraj, John Myers, Rodney J Folz, Barbara J Polivka
BACKGROUND: The diagnosis of asthma is not always straightforward and can be even more challenging in older adults. Asthma is ideally confirmed by demonstration of variable expiratory airflow limitation. However, many patients with asthma do not demonstrate airflow obstruction nor show bronchodilator reversibility. We aimed to investigate predictors for a positive bronchial challenge test with methacholine in older adults being evaluated for asthma. METHODS: This is a diagnostic accuracy study with a cross-sectional design...
September 2018: Respiratory Medicine
Margit K Pelkonen, Irma-Leena K Notkola, Tiina K Laatikainen, Pekka Jousilahti
INTRODUCTION: The present study examines how trends in the prevalence of asthma during the past three decades associate with hospitalization and mortality during the same period. METHODS: Altogether 54 320 subjects aged 25-74 years were examined in seven independent cross-sectional population surveys repeated every five years between 1982 and 2012 in Finland. The study protocol included a standardized questionnaire on self-reported asthma, smoking habits and other risk factors, and clinical measurements at the study site...
September 2018: Respiratory Medicine
Nathan Ward, Kathy Stiller, Hilary Rowe, Scott Morrow, Judith Morton, Hugh Greville, Anne E Holland
BACKGROUND: People with cystic fibrosis (CF) are encouraged to perform airway clearance techniques on a daily basis. Whilst several short-term studies support a potential role for exercise as an airway clearance technique, to date no medium to longer term studies have investigated the use of exercise as a stand-alone airway clearance technique. OBJECTIVE: To determine the feasibility of a protocol investigating the use of exercise as a stand-alone form of airway clearance in adults with CF...
September 2018: Respiratory Medicine
Andriana I Papaioannou, Zuzana Diamant, Petros Bakakos, Stelios Loukides
Asthma is a common disease, and although its clinical manifestations may be similar among patients, recent research discoveries have shown that it consists of several distinct clinical clusters or phenotypes, each with different underlying molecular pathways yielding different treatment responses. Based on these observations, an alternative approach - known as 'precision medicine' - has been proposed for the management of patients with severe asthma. Precision medicine advocates identification of treatable traits, linking them to therapeutic approaches targeting genetic, immunological, environmental, and/or lifestyle factors in individual patients...
September 2018: Respiratory Medicine
María Luisa Aznar, Marijana Zubrinic, Miranda Siemienowicz, Kohei Hashimoto, Sarah Kathleen Brode, Mahtab Mehrabi, Demetris Patsios, Shafique Keshavjee, Theodore Konstantine Marras
BACKGROUND AND OBJECTIVES: Lung resection in patients with nontuberculous mycobacterial pulmonary disease (NTM-PD) is considered when medical therapy alone fails to provide long term control. Data regarding comparative and long-term outcomes are limited. We aimed to review indications and outcomes of adjuvant lung resection for NTM-PD compared with controls. METHODS: We retrospectively studied 27 surgically treated patients, matched 1:1 for age, sex, NTM species, and radiologic pattern of disease, with control patients treated exclusively with antibiotics...
September 2018: Respiratory Medicine
Sabina Škrgat, Peter Korošec, Izidor Kern, Mira Šilar, Julij Šelb, Matjaž Fležar, Robert Marčun
No abstract text is available yet for this article.
September 2018: Respiratory Medicine
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