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Respiratory Medicine

Ji Eun Park, Young Sam Kim, Min Jin Kang, Cheong Ju Kim, Chang Hoon Han, Sun Min Lee, Seon Cheol Park
BACKGROUND: The prevalence and incidence of sarcoidosis, a granulomatous disorder involving multiple organ systems, varies among geographical regions and ethnicities. This study evaluated the incidence, prevalence, and mortality of sarcoidosis in a large nationwide population-based cohort in Korea. METHODS: We used data of the National Health Insurance Service database, which is an extensive health-related database including most Korean residents. Adults with a primary diagnosis of sarcoidosis, as determined by International Classification of Disease-Tenth Revision coding (D86), were identified between 2003 and 2015...
April 3, 2018: Respiratory Medicine
Sabina Škrgat, Peter Korošec, Izidor Kern, Mira Šilar, Julij Šelb, Matjaž Fležar, Robert Marčun
No abstract text is available yet for this article.
April 3, 2018: Respiratory Medicine
Bryan S Benn, Zoe Lehman, Sharon A Kidd, Christine Miaskowski, Bernie Y Sunwoo, Melissa Ho, Sara Sun, Joris Ramstein, Jeffrey M Gelfand, Laura L Koth
INTRODUCTION: Sarcoidosis is a systemic inflammatory disease associated with myriad symptoms, including fatigue. It can affect physiological processes like sleep, leading to poor sleep quality and excessive daytime sleepiness. We hypothesized that sarcoidosis patients would report more severe sleep disturbance than healthy controls and that relationships would be found with sleep disturbance and the severity of other symptoms. METHODS: We enrolled 84 sarcoidosis patients and 30 healthy controls and recorded demographic and clinical characteristics...
March 24, 2018: Respiratory Medicine
Fatemeh Khosravi Shadmani, Kamyar Mansori
No abstract text is available yet for this article.
March 20, 2018: Respiratory Medicine
Jerome M Reich
No abstract text is available yet for this article.
March 10, 2018: Respiratory Medicine
Anne Lindberg, Per S Bakke, Johann Christian Virchow, Bo Lundbäck
No abstract text is available yet for this article.
March 5, 2018: Respiratory Medicine
Joseph Jacob, Arlette Odink, Anne Laure Brun, Claudio Macaluso, Angelo de Lauretis, Maria Kokosi, Anand Devaraj, Sujal Desai, Elisabetta Renzoni, Athol U Wells
BACKGROUND: Pleuroparenchymal fibroelastosis (PPFE) has been described in hypersensitivity pneumonitis (HP) yet its functional implications are unclear. Combined pulmonary fibrosis and emphysema (CPFE) has occasionally been described in never-smokers with HP, but epidemiological data regarding its prevalence is sparse. CTs in a large HP cohort were therefore examined to identify the prevalence and effects of PPFE and emphysema. METHODS: 233 HP patients had CT extents of interstitial lung disease (ILD) and emphysema quantified to the nearest 5%...
May 2018: Respiratory Medicine
Francesco Blasi, Vincenzo Carnovale, Giuseppe Cimino, Vincenzina Lucidi, Donatello Salvatore, Barbara Messore, Marta Bartezaghi, Elisa Muscianisi, Pasquale Alberto Porpiglia
BACKGROUND: A high treatment burden with nebulised therapies in cystic fibrosis (CF) patients is the major limitation for treatment compliance; moreover, studies on treatment compliance with inhaled antibiotics are limited. This study assessed compliance to TOBI® Podhaler™ (TIP) treatment in CF patients with chronic Pseudomonas aeruginosa (Pa) infections in a real-world setting using the Italian Treatment Adherence CF Questionnaire (ITA-CFq). METHODS: This longitudinal, multicentre, cohort study included 2 follow-up (FU) visits: FU-1 at 3-months±15-days from the baseline visit and FU-2 at the end of third TIP cycle (or 6-months after enrolment, whichever occurred first)...
May 2018: Respiratory Medicine
Renae J McNamara, Sarah Houben-Wilke, Frits M E Franssen, Dionne E Smid, Lowie E G W Vanfleteren, Miriam T J Groenen, Nicole H M K Uszko-Lencer, Emiel F M Wouters, Jennifer A Alison, Martijn A Spruit
BACKGROUND: Exercise limitation in COPD is multi-factorial. The contribution of cardiac function to exercise capacity is not clear. METHODS: Potential determinants of the different constructs of exercise capacity (functional, peak and endurance exercise capacity using the 6-minute walk distance (6MWD), peak oxygen uptake (VO2 peak) and peak work load, and sub-maximal constant work rate test (CWRT) cycle time, respectively) were analysed. RESULTS: Data were collected in 516 people with COPD (56% male, age (mean ± SD) 64 ± 9 years, FEV1 % predicted 49 ± 20%)...
May 2018: Respiratory Medicine
Faisal Fakih, Selwyn Spangenthal, Barry Sigal, Patrick Darken, Andrea Maes, Shahid Siddiqui, Michael Gillen, Colin Reisner, Ubaldo J Martin
OBJECTIVES: This study compared the efficacy, pharmacokinetics (PK), and safety of GFF MDI (Bevespi Aerosphere® ), a fixed-dose combination of glycopyrronium and formoterol fumarate dihydrate (14.4/10 μg) delivered by a metered dose inhaler (MDI) formulated using innovative co-suspension delivery technology, in patients with moderate-to-very severe chronic obstructive pulmonary disease (COPD) with and without the Aerochamber Plus® Flow-Vu® valved holding chamber (VHC). METHODS: In this multicenter, open-label, crossover, Phase III study (NCT02454959), patients were randomized to receive GFF MDI 14...
May 2018: Respiratory Medicine
Zafar Zafari, Mohsen Sadatsafavi, Wenjia Chen, J Mark FitzGerald
BACKGROUND: Achieving optimal control is the primary objective of asthma management. However, despite the existence of effective treatments, many patients experience periods of sub-optimal asthma control. The objective of this study was to quantify and project the future economic and health burden of sub-optimal asthma control in Canada. METHODS: A probabilistic time-in-state model of asthma was created with inputs from published studies on the prevalence of asthma, levels of asthma control, and the impact of asthma control on costs and quality of life...
May 2018: Respiratory Medicine
Hesham Tarraf, Hamdan Al-Jahdali, Abdul Hameed Al Qaseer, Anamarija Gjurovic, Houria Haouichat, Basheer Khassawneh, Bassam Mahboub, Roozbeh Naghshin, François Montestruc, Naser Behbehani
BACKGROUND: Low levels of asthma control are reported in many countries worldwide. Improved knowledge of asthma control in the Middle East and Africa and predictive factors is needed to address this major public healthcare burden. OBJECTIVE: To assess the level of asthma control in patients attending a routine consultation for asthma in the Middle East and North Africa, and the relationship between level of control and patient and disease characteristics, adherence, and quality of life (QoL)...
May 2018: Respiratory Medicine
Ana Oliveira, João Rodrigues, Alda Marques
BACKGROUND: Timely diagnosis of acute exacerbations of COPD (AECOPD) is challenging as it depends on patients' reports. AECOPD are characterised by increased airway obstruction, mucus and air trapping, which results in changes in lung acoustics. Thus, adventitious respiratory sounds (ARS) may be useful to detect/monitor AECOPD. OBJECTIVE: To evaluate computerised ARS changes during AECOPD. METHODS: 25 non-hospitalised patients with AECOPD (16♂, 70 [62...
May 2018: Respiratory Medicine
Laxmi Bhatta, Linda Leivseth, Xiao-Mei Mai, Yue Chen, Anne Hildur Henriksen, Arnulf Langhammer, Ben Michael Brumpton
BACKGROUND: COPD is a major cause of morbidity and mortality across the world and new estimates of prevalence and trend are of great importance. We aimed to estimate the prevalence and trend of COPD from 1995-1997 to 2006-2008 in Norwegian adults ≥40 years from the Nord-Trøndelag Health Study. MATERIAL AND METHODS: COPD was assessed using a fixed-ratio and lower limit of normal (LLN) criteria. Pre-bronchodilator spirometry was performed during 1995-1997 (n = 7158) and 2006-2008 (n = 8788)...
May 2018: Respiratory Medicine
Jennifer M Burke, Warren Jackson, Alyn H Morice
PURPOSE: Cough Hypersensitivity Syndrome is the urge to cough following minimal stimulation, but its mechanism and method of provocation remain unexplained. 121 patients (44 males, 77 females; age range 18-81 years) were evaluated. PROCEDURES: High resolution manometry was performed on consecutive patients presenting with unexplained respiratory symptoms (Respiratory Group 61). Data were compared with matched controls, i.e. dyspepsia without respiratory symptoms (Dyspepsia Group 60)...
May 2018: Respiratory Medicine
Oluwafemi Oluwole, Donna C Rennie, Ambikaipakan Senthilselvan, Roland Dyck, Anna Afanasieva, Shelley Kirychuk, George Katselis, Joshua A Lawson
BACKGROUND: Asthma severity can be affected by microbial exposures. However, less is known about the specific indoor agents aggravating the disease in children. We examined the associations between indoor endotoxin and beta-(1 → 3)-D-glucan exposures and asthma severity in children with asthma. METHODS: A clinical cross-sectional study of schoolchildren (aged 7-17 years) was conducted in the province of Saskatchewan, Canada. Children with asthma (n = 116) were identified from 335 participants using a combination of survey responses and objective clinical assessments...
May 2018: Respiratory Medicine
Deepa Ramadurai, Maeveen Riordan, Bridget Graney, Tara Churney, Amy L Olson, Jeffrey J Swigris
BACKGROUND: May patients with interstitial lung disease (ILD) require supplementary oxygen (O2 ) therapy to maintain normoxia. However, ambulatory O2 delivery devices are constraining and cumbersome. The physiologic and symptomatic impact of these devices on ILD patients is unknown. METHODS: We conducted a prospective study of 30 clinically stable ILD patients (with varying disease severity), half of whom used O2 at baseline. Each subject completed two six-minute walk tests (6MWTs); for O2 users, one walk was completed while wearing a backpack (weight 7...
May 2018: Respiratory Medicine
Guy Brusselle, Ian D Pavord, Sarah Landis, Steven Pascoe, Sally Lettis, Nikhil Morjaria, Neil Barnes, Emma Hilton
Chronic obstructive pulmonary disease (COPD) is a heterogeneous disorder and patients respond differently to treatment. Blood eosinophils are a potential biomarker to stratify patient subsets for COPD therapy. We reviewed the value of blood eosinophils in predicting exacerbation risk and response to corticosteroid treatment in the available literature (PubMed articles in English; keywords: "COPD" and "eosinophil"; published prior to May 2017). Overall, clinical data suggest that in patients with a history of COPD exacerbations, a higher blood eosinophil count predicts an increased risk of future exacerbations and is associated with improved response to treatment with inhaled corticosteroids (in combination with long-acting bronchodilator[s])...
May 2018: Respiratory Medicine
Daniel R Morales, Rob Flynn, Jianguo Zhang, Emmanuel Trucco, Jennifer K Quint, Kris Zutis
BACKGROUND: Several models for predicting the risk of death in people with chronic obstructive pulmonary disease (COPD) exist but have not undergone large scale validation in primary care. The objective of this study was to externally validate these models using statistical and machine learning approaches. METHODS: We used a primary care COPD cohort identified using data from the UK Clinical Practice Research Datalink. Age-standardised mortality rates were calculated for the population by gender and discrimination of ADO (age, dyspnoea, airflow obstruction), COTE (COPD-specific comorbidity test), DOSE (dyspnoea, airflow obstruction, smoking, exacerbations) and CODEX (comorbidity, dyspnoea, airflow obstruction, exacerbations) at predicting death over 1-3 years measured using logistic regression and a support vector machine learning (SVM) method of analysis...
May 2018: Respiratory Medicine
Jing Li, Huan Yao, Yan Lei, Yanyong Ye
INTRODUCTION: Although human intrapleural hyperthermic perfusion (HIHP) has achieved excellent palliative effects in metastatic pleural malignancies, the optimum treatment conditions, including inlet temperature and treatment times based on tumor size, have yet to be determined. However, such information is recognized to be critical for treatment planning in clinics. Therefore, the current research aimed to solve these issues. METHODS: Using the finite-element method (FEM), a simplified three-dimensional HIHP model was established and verified according to the temperature data of specific measuring points based on a clinical therapeutic case...
May 2018: Respiratory Medicine
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