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Journal of Psychopharmacology

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https://www.readbyqxmd.com/read/28198658/effects-of-acute-and-chronic-caffeine-on-risk-taking-behavior-in-children-and-adolescents
#1
Jennifer L Temple, Amanda M Ziegler, Adam M Graczyk, Amanda Crandall
Consumption of caffeinated beverages is associated with increased risk-taking behavior. The purpose of this study was to determine if acute caffeine administration influences risk-taking behavior in a dose-dependent manner. Participants were pre- (ages 8-9) and post-pubertal (ages 15-17) children who visited the laboratory three times and consumed a beverage containing 0, 1, or 2 mg/kg of caffeine. Thirty minutes later, participants completed the balloon analogue risk task (BART), the Iowa gambling task (IGT), and a delay discounting task...
February 1, 2017: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/28198211/both-n-methyl-d-aspartate-and-non-n-methyl-d-aspartate-glutamate-receptors-in-the-bed-nucleus-of-the-stria-terminalis-modulate-the-cardiovascular-responses-to-acute-restraint-stress-in-rats
#2
Mariane B Adami, Lucas Barretto-de-Souza, Josiane O Duarte, Jeferson Almeida, Carlos C Crestani
The bed nucleus of the stria terminalis (BNST) is a forebrain structure that has been implicated on cardiovascular responses evoked by emotional stress. However, the local neurochemical mechanisms mediating the BNST control of stress responses are not fully described. In our study we investigated the involvement of glutamatergic neurotransmission within the BNST in cardiovascular changes evoked by acute restraint stress in rats. For this study, we investigated the effects of bilateral microinjections of selective antagonists of either N-methyl-D-aspartate (NMDA) or non-NMDA glutamate receptors into the BNST on the arterial pressure and heart rate increase and the decrease in tail skin temperature induced by acute restraint stress...
February 1, 2017: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/28196430/first-in-human-trial-of-a-type-i-positive-allosteric-modulator-of-alpha7-nicotinic-acetylcholine-receptors-pharmacokinetics-safety-and-evidence-for-neurocognitive-effect-of-avl-3288
#3
Kelvin W Gee, Ann Olincy, Richard Kanner, Lynn Johnson, Derk Hogenkamp, Josette Harris, Minhtam Tran, Stephen A Edmonds, William Sauer, Ryan Yoshimura, Timothy Johnstone, Robert Freedman
Type I positive allosteric modulators (PAMs) of the alpha7-nicotinic receptor enhance its cholinergic activation while preserving the spatiotemporal features of synaptic transmission and the receptor's characteristic rapid desensitization kinetics. Alpha7-nicotinic receptor agonists have shown promise for improving cognition in schizophrenia, but longer-term trials have been disappointing. Therefore, the type I PAM AVL-3288 was evaluated for safety and preliminary evidence of neurocognitive effect in healthy human subjects...
February 1, 2017: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/28196428/the-association-of-psychedelic-use-and-opioid-use-disorders-among-illicit-users-in-the-united-states
#4
Vincent D Pisano, Nathaniel P Putnam, Hannah M Kramer, Kevin J Franciotti, John H Halpern, Selma C Holden
BACKGROUND: Preliminary studies show psychedelic compounds administered with psychotherapy are potentially effective and durable substance misuse interventions. However, little is known about the association between psychedelic use and substance misuse in the general population. This study investigated the association between psychedelic use and past year opioid use disorders within illicit opioid users. METHODS: While controlling for socio-demographic covariates and the use of other substances, the relationship between classic psychedelic use and past year opioid use disorders was analyzed within 44,000 illicit opioid users who completed the National Survey on Drug Use and Health from 2008 to 2013...
February 1, 2017: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/28193131/corrigendum
#5
(no author information available yet)
No abstract text is available yet for this article.
February 1, 2017: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/28208023/transcriptomic-profiling-of-human-hippocampal-progenitor-cells-treated-with-antidepressants-and-its-application-in-drug-repositioning
#6
Timothy R Powell, Tytus Murphy, Sang H Lee, Jack Price, Sandrine Thuret, Gerome Breen
Current pharmacological treatments for major depressive disorder (MDD) are ineffective in a significant proportion of patients, and the identification of new antidepressant compounds has been difficult. 'Connectivity mapping' is a method that can be used to identify drugs that elicit similar downstream effects on mRNA levels when compared to current treatments, and thus may point towards possible repositioning opportunities. We investigated genome-wide transcriptomic changes to human hippocampal progenitor cells treated with therapeutically relevant concentrations of a tricyclic antidepressant (nortriptyline) and a selective serotonin reuptake inhibitor (escitalopram)...
January 1, 2017: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/28168896/binge-drinking-affects-brain-oscillations-linked-to-motor-inhibition-and-execution
#7
Eduardo López-Caneda, Socorro Rodríguez Holguín, Ángeles Correas, Carina Carbia, Alberto González-Villar, Fernando Maestú, Fernando Cadaveira
INTRODUCTION: Neurofunctional studies have shown that binge drinking patterns of alcohol consumption during adolescence and youth are associated with anomalies in brain functioning. Recent evidence suggests that event-related oscillations may be an appropriate index of neurofunctional damage associated with alcoholism. However, there is no study to date that has evaluated the effects of binge drinking on oscillatory brain responses related to task performance. The purpose of the present study was to examine brain oscillations linked to motor inhibition and execution in young binge drinkers (BDs) compared with age-matched controls...
January 1, 2017: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/28168894/effect-of-combined-opioid-receptor-and-%C3%AE-2-adrenoceptor-blockade-on-anxiety-and-electrically-evoked-startle-responses
#8
Lechi Vo, Peter D Drummond
The R3 component of the electrically evoked blink reflex may form part of a startle reaction. Acoustic startle responses are augmented by yohimbine, an α2-adrenoceptor antagonist that blocks α2-autoreceptors, and are potentiated by opioid receptor blockade. To investigate these influences on electrically evoked startle responses, 16 mg yohimbine, with (16 participants) or without 50 mg naltrexone (23 participants), was administered in separate double-blind placebo-controlled cross-over experiments. In each experiment, R3 (a probable component of the startle response) was examined before and after high-frequency electrical stimulation of the forearm, a procedure that initiates inhibitory pain controls...
January 1, 2017: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/28142305/effects-of-acute-and-repeated-treatment-with-the-biased-mu-opioid-receptor-agonist-trv130-oliceridine-on-measures-of-antinociception-gastrointestinal-function-and-abuse-liability-in-rodents
#9
Ahmad A Altarifi, Bethany David, Karan H Muchhala, Bruce E Blough, Hamid Akbarali, S Stevens Negus
RATIONALE: TRV130 (oliceridine; N-[(3-methoxythiophen-2-yl)methyl]-2-[(9 R)-9-pyridin-2-yl-6-oxaspiro[4.5]decan-9-yl]ethanamine) is a novel mu opioid receptor (MOR) agonist that preferentially activates G-protein versus β-arrestin signaling pathways coupled to MORs. Prevailing evidence suggests that TRV130 and other G-protein-biased MOR agonists may produce therapeutic analgesic effects with reduced adverse effects compared to existing MOR agonists. OBJECTIVES: This study compared the effects of acute and repeated TRV130 administration on measures of antinociception, gastrointestinal function, and abuse liability in rodents...
January 1, 2017: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/28135888/curcumin-for-neuropsychiatric-disorders-a-review-of-in-vitro-animal-and-human-studies
#10
Adrian L Lopresti
Turmeric has been used in traditional medicine for centuries to treat a range of ailments. Its primary active constituent curcumin, can influence an array of biological activities. Many of these, such as its anti-inflammatory, antioxidant, neuroprotective, and monoaminergic effects are dysregulated in several neuropsychiatric disorders. In this systematic review, in vitro, animal, and human studies investigating the potential of curcumin as a treatment for neuropsychiatric disorders such as major depressive disorder, post-traumatic stress disorder (PTSD), obsessive-compulsive disorder (OCD), bipolar disorder, psychotic disorders, and autism are reviewed, and directions for future research are proposed...
January 1, 2017: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/28135884/intranasal-administration-of-dopamine-attenuates-unconditioned-fear-in-that-it-reduces-restraint-induced-ultrasound-vocalizations-and-escape-from-bright-light
#11
Teddy Talbot, Claudia Mattern, Maria Angelica de Souza Silva, Marcus Lira Brandão
BACKGROUND: Although substantial evidence suggests that dopamine (DA) enhances conditioned fear responses, few studies have examined the role of DA in unconditioned fear states. Whereas DA does not cross the blood-brain barrier, intranasally-applied dopamine reaches the brain directly via the nose-brain pathways in rodents, providing an alternative means of targeting DA receptors. Intranasal dopamine (IN-DA) has been demonstrated to bind to DA transporters and to increase extracellular DA in the striatum as well as having memory-promoting effects in rats...
January 1, 2017: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/28121219/amiloride-sensitive-cation-channel-2-genotype-affects-the-response-to-a-carbon-dioxide-panic-challenge
#12
Nicole K Leibold, Daniel LA van den Hove, Wolfgang Viechtbauer, Gunter Kenis, Liesbet Goossens, Iris Lange, Inge Knuts, Hubert J Smeets, Inez Myin-Germeys, Harry Wm Steinbusch, Koen Rj Schruers
Until recently, genetic research into panic disorder (PD) has had only limited success. Inspired by rodent research, demonstrating that the acid-sensing ion channel 1a (ASIC1a) is critically involved in the behavioral fear response to carbon dioxide (CO2) exposure, variants in the human homologue gene amiloride-sensitive cation channel 2 (ACCN2) were shown to be associated with PD. However, the relationship between changes in brain pH and ACCN2, as done in rodents by CO2 exposure, has not been investigated yet in humans...
January 1, 2017: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/28114845/effects-of-perinatal-diet-and-prenatal-stress-on-the-behavioural-profile-of-aged-male-and-female-rats
#13
Xabier Bengoetxea, Laura Paternain, Eva Martisova, Fermin I Milagro, J Alfredo Martínez, Javier Campión, María J Ramírez
The present work studies whether chronic prenatal stress (PS) influences the long-term sex-dependent neuropsychological status of offspring and the effects of an early dietary intervention in the dam. In addition, dams were fed with either a high-fat sugar diet (HFSD) or methyl donor supplemented diet (MDSD). PS procedure did not affect body weight of the offspring. MDSD induced decreases in body weight both in male and female offspring (1 month) that were still present in aged rats. HFSD induced an increase in body weight both in male and female offspring that did not persist in aged rats...
January 1, 2017: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/28114835/dorsal-striatum-d1-expressing-neurons-are-involved-with-sensorimotor-gating-on-prepulse-inhibition-test
#14
Samanta Rodrigues, Cristiane Salum, Tatiana L Ferreira
Prepulse inhibition (PPI) is a behavioral test in which the startle reflex response to a high-intensity stimulus (pulse) is inhibited by the prior presentation of a weak stimulus (prepulse). The classic neural circuitry that mediates startle response is localized in the brainstem; however, recent studies point to the contribution of structures involved in higher cognitive functions in regulating the sensorimotor gating, particularly forebrain regions innervated by dopaminergic nuclei. The aim of the present study was to verify the role of dorsal striatum (DS) and dopaminergic transmitting mediated by D1 and D2 receptors on PPI test in rats...
January 1, 2017: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/28095732/an-online-survey-of-tobacco-smoking-cessation-associated-with-naturalistic-psychedelic-use
#15
Matthew W Johnson, Albert Garcia-Romeu, Patrick S Johnson, Roland R Griffiths
Data suggest psychedelics such as psilocybin and lysergic acid diethylamide (LSD) may hold therapeutic potential in the treatment of addictions, including tobacco dependence. This retrospective cross-sectional anonymous online survey characterized 358 individuals (52 females) who reported having quit or reduced smoking after ingesting a psychedelic in a non-laboratory setting ⩾1 year ago. On average, participants smoked 14 cigarettes/day for 8 years, and had five previous quit attempts before their psychedelic experience...
January 1, 2017: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/28093029/low-doses-of-mirtazapine-or-quetiapine-for-transient-insomnia-a-randomised-double-blind-cross-over-placebo-controlled-trial
#16
Julie Karsten, Loes A Hagenauw, Jeanine Kamphuis, Marike Lancel
Low doses of the antidepressant mirtazapine or the neuroleptic quetiapine are often prescribed off-label for insomnia. However, studies on the effects on sleep and hangover effects the following day are scarce. In this randomised, double-blind, cross-over, placebo-controlled trial, the influence of 7.5 mg mirtazapine and 50 mg quetiapine on both normal sleep and sleep disturbed by acoustic stress (traffic noise) as a model for transient insomnia was assessed. Additionally, hangover effects on next-day alertness and cognitive functioning were examined...
January 1, 2017: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/28093022/blunted-neural-response-to-anticipation-effort-and-consummation-of-reward-and-aversion-in-adolescents-with-depression-symptomatology
#17
Ewelina Rzepa, Jennifer Fisk, Ciara McCabe
Neural reward function has been proposed as a possible biomarker for depression. However, how the neural response to reward and aversion might differ in young adolescents with current symptoms of depression is as yet unclear. Thirty-three adolescents were recruited, 17 scoring low on the Mood and Feelings Questionnaire (low risk group) and 16 scoring high (high risk group). Our functional magnetic resonance imaging task measured; anticipation (pleasant/unpleasant cue), effort (achieve a pleasant taste or avoid an unpleasant taste) and consummation (pleasant/unpleasant tastes) in regions of interest; ventral medial prefrontal cortex, pregenual cingulate cortex, the insula and ventral striatum...
January 1, 2017: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/28093021/altering-ethanol-pharmacokinetics-to-treat-alcohol-use-disorder-can-you-teach-an-old-dog-new-tricks
#18
Carolina L Haass-Koffler, Fatemeh Akhlaghi, Robert M Swift, Lorenzo Leggio
Disulfiram was the first pharmacotherapy approved to treat alcohol use disorder in the 1950s. Disulfiram alters ethanol pharmacokinetics and causes uncomfortable reactions (e.g. headache, tachycardia, nausea, flushing and hypotension) when alcohol is consumed. Subsequently, a better understanding of the neurobiological pathways involved in alcohol use disorder led to the development of other medications (e.g. naltrexone and acamprosate). These neurobiological-based medications act on alcohol use disorder-related phenotypes including craving, stress, and/or withdrawal...
January 1, 2017: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/28093016/acute-and-residual-effects-in-adolescent-rats-resulting-from-exposure-to-the-novel-synthetic-cannabinoids-ab-pinaca-and-ab-fubinaca
#19
Richard C Kevin, Katie E Wood, Jordyn Stuart, Andrew J Mitchell, Michael Moir, Samuel D Banister, Michael Kassiou, Iain S McGregor
Synthetic cannabinoids (SCs) have rapidly proliferated as recreational drugs, and may present a substantial health risk to vulnerable populations. However, information on possible effects of long-term use is sparse. This study compared acute and residual effects of the popular indazole carboxamide SC compounds AB-PINACA and AB-FUBINACA in adolescent rats with ∆(9)-tetrahydrocannabinol (THC) and control treatments. Albino Wistar rats were injected (i.p.) with AB-PINACA or AB-FUBINACA every second day (beginning post-natal day (PND) 31), first at a low dose (0...
January 1, 2017: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/28093014/using-invivostat-to-perform-the-statistical-analysis-of-experiments
#20
Simon T Bate, Robin A Clark, S Clare Stanford
The need to improve reproducibility and reliability of animal experiments has led some journals to increase the stringency of the criteria that must be satisfied before manuscripts can be considered suitable for publication. In this article we give advice on experimental design, including minimum group sizes, calculating statistical power and avoiding pseudo-replication, which can improve reproducibility. We also give advice on normalisation, transformations, the gateway analysis of variance strategy and the use of p-values and confidence intervals...
January 1, 2017: Journal of Psychopharmacology
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