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Journal of Psychopharmacology

Chris Barkus, Jacqueline-Marie N Ferland, Wendy K Adams, Grant C Churchill, Philip J Cowen, David M Bannerman, Robert D Rogers, Catharine A Winstanley, Trevor Sharp
BACKGROUND: Deficits in impulse control feature in many psychiatric conditions including bipolar disorder, suicidality and addictions. Lithium lowers impulsivity in clinical populations and decreases pathological gambling in experimental medicine studies, but suffers from adverse effects, poor compliance and a low therapeutic index. AIMS: Recently we identified that the neuroprotective agent ebselen, which is reportedly safe in humans, inhibited inositol monophosphatase (IMPase), a candidate lithium mechanism...
July 1, 2018: Journal of Psychopharmacology
Julian Macoveanu, Kirsa M Demant, Maj Vinberg, Hartwig R Siebner, Lars V Kessing, Kamilla W Miskowiak
BACKGROUND: Cognitive deficits are prevalent in bipolar disorder during remission but effective cognition treatments are lacking due to insufficient insight into the neurobiological targets of cognitive improvement. Emerging data suggest that dorsal prefrontal cortex target engagement is a key neurocircuitry biomarker of pro-cognitive treatment effects. AIMS: In this randomized controlled functional magnetic resonance imaging study, we test this hypothesis by investigating the effects of an ineffective cognitive remediation intervention on dorsal prefrontal response during strategic memory encoding and working memory engagement...
July 1, 2018: Journal of Psychopharmacology
Ariandra G Sartim, Amanda J Sales, Francisco S Guimarães, Sâmia R L Joca
BACKGROUND: Cannabidiol is a non-psychotomimetic compound with antidepressant-like effects. However, the mechanisms and brain regions involved in cannabidiol effects are not yet completely understood. Brain-derived neurotrophic factor/tropomyosin-receptor kinase B/mammalian target of rapamycin (BDNF-TrkB-mTOR) signaling, especially in limbic structures, seems to play a central role in mediating the effects of antidepressant drugs. AIM: Since it is not yet known if BDNF-TrkB-mTOR signaling in the hippocampus is critical to the antidepressant-like effects of cannabidiol, we investigated the effects produced by cannabidiol (10/30/60 nmol/0...
June 1, 2018: Journal of Psychopharmacology
Marco Battaglia, Orlane Rossignol, Karine Bachand, Francesca R D'Amato, Yves De Koninck
BACKGROUND: Early life adversities are risk factors for anxiety disorders and for pain syndromes, which are, in turn, highly comorbid with anxiety disorders. Repeated cross-fostering mouse pups to adoptive lactating females induces epigenetic modification and heightened mRNA-expression of the acid-sensing-ion-channel-1 gene, altered nociception, and hypersensitivity to 6% carbon dioxide air mixtures, a trait marker of specific human anxiety disorders such as, most clearly and prominently, panic disorder...
June 1, 2018: Journal of Psychopharmacology
Andrew P Smith, Gareth Richards
BACKGROUND: Energy drinks are widely consumed, and concerns have been raised about possible negative outcomes. AIMS: The aim of the present research was to examine associations between consumption of energy drinks, caffeine and junk food, and academic attainment in a sample of UK secondary school students. METHODS: A total of 3071 students agreed to participate in the study; 2677 completed the survey on one occasion (52.4% female, 47.6% male; approximately 20% of the sample from each school year) and 1660 (49...
June 1, 2018: Journal of Psychopharmacology
Nadia Rpw Hutten, Kim Pc Kuypers, Janelle Hp van Wel, Eef L Theunissen, Stefan W Toennes, Robbert-Jan Verkes, Johannes G Ramaekers
BACKGROUND: Prospective memory is the ability to recall intended actions or events at the right time or in the right context. While cannabis is known to impair prospective memory, the acute effect of cocaine is unknown. In addition, it is not clear whether changes in prospective memory represent specific alterations in memory processing or result from more general effects on cognition that spread across multiple domains such as arousal and attention. AIMS: The main objective of the study was, therefore, to determine whether drug-induced changes in prospective memory are memory specific or associated with more general drug-induced changes in attention and arousal...
June 1, 2018: Journal of Psychopharmacology
Christopher R Nicholas, Kelsey M Henriquez, Michele C Gassman, Karen M Cooper, Daniel Muller, Scott Hetzel, Randall T Brown, Nicholas V Cozzi, Chantelle Thomas, Paul R Hutson
AIM: The aim of the current study was to investigate the relationship between escalating higher doses of psilocybin and the potential psilocybin occasioned positive subjective effects. METHODS: Healthy participants ( n=12) were given three escalating doses of oral psilocybin (0.3 mg/kg; 0.45 mg/kg; 0.6 mg/kg) or (18.8-36.6 mg; 27.1-54.0 mg; 36.3-59.2 mg) a minimum of four weeks apart in a supervised setting. Blood and urine samples, vital signs, and electrocardiograms were obtained...
June 1, 2018: Journal of Psychopharmacology
Christopher Rohde, Rikke Hilker, Dan Siskind, Jimmi Nielsen
BACKGROUND: Comorbid mental illness is common in patients with intellectual disability. Antipsychotics are widely used for these conditions, but the effect of clozapine remains largely unknown. AIMS: We aimed to investigate the effectiveness of clozapine on naturalistic outcomes in patients with intellectual disability. METHODS: By combining the national health registers, we identified all patients in Denmark with intellectual disability initiating clozapine treatment during the period 1996-2012...
June 1, 2018: Journal of Psychopharmacology
Tehseen Noorani, Albert Garcia-Romeu, Thomas C Swift, Roland R Griffiths, Matthew W Johnson
BACKGROUND: Recent pilot trials suggest feasibility and potential efficacy of psychedelic-facilitated addiction treatment interventions. Fifteen participants completed a psilocybin-facilitated smoking cessation pilot study between 2009 and 2015. AIMS: The aims of this study were as follows: (1) to identify perceived mechanisms of change leading to smoking cessation in the pilot study; (2) to identify key themes in participant experiences and long-term outcomes to better understand the therapeutic process...
June 1, 2018: Journal of Psychopharmacology
Clément E Lemercier, Devin B Terhune
BACKGROUND: Recent research on psychedelics and hypnosis demonstrates the value of both methods in the treatment of a range of psychopathologies with overlapping applications and neurophenomenological features. The potential of harnessing the power of suggestion to influence the phenomenological response to psychedelics toward more therapeutic action has remained unexplored in recent research and thereby warrants empirical attention. AIMS: Here we aim to elucidate the phenomenological and neurophysiological similarities and dissimilarities between psychedelic states and hypnosis in order to revisit how contemporary knowledge may inform their conjunct usage in psychotherapy...
June 1, 2018: Journal of Psychopharmacology
David Pj Osborn, Irene Petersen, Nick Beckley, Kate Walters, Irwin Nazareth, Joseph Hayes
BACKGROUND: Follow-up studies of weight gain related to antipsychotic treatment beyond a year are limited in number. We compared weight change in the three most commonly prescribed antipsychotics in a representative UK General Practice database. METHOD: We conducted a cohort study in United Kingdom primary care records of people newly prescribed olanzapine, quetiapine or risperidone. The primary outcome was weight in each six month period for two years after treatment initiation...
June 1, 2018: Journal of Psychopharmacology
Che-Sheng Chu, Wan-Rung Li, Kuan-Lun Huang, Pei-Yu Su, Ching-Heng Lin, Tsuo-Hung Lan
OBJECTIVE: The purpose of this study was to identify the association between antipsychotics and mortality in Alzheimer's disease patients. METHODS: Using the Taiwan National Health Insurance Research Database, 735 newly diagnosed Alzheimer's disease patients aged over 65 years and receiving antipsychotic treatments, and 735 age, sex, physical comorbidity, and entry year with propensity scores, matched control subjects were enrolled and followed for a 10-year period until the end of 2011...
June 1, 2018: Journal of Psychopharmacology
Kira-Elise Wilson, Sigrid Limburg, Melissa K Duggan, Adam J Lawther, Spencer J Williams, Andrew J Lawrence, Matthew W Hale, Elvan Djouma
INTRODUCTION: This study aimed to investigate the effects of the galanin-3 receptor antagonist, SNAP 37889, on c-Fos protein expression after cue-induced reinstatement of alcohol-seeking in the brains of alcohol-preferring rats. METHODS: Eighteen alcohol-preferring rats were trained to self-administer 10% v/v ethanol in the presence of response-contingent cues, which was followed by extinction. Rats were then treated with SNAP 37889 (30 mg/kg, i.p.) or vehicle, before being tested for cue-induced reinstatement...
June 1, 2018: Journal of Psychopharmacology
Zachary J Zimmermann, David V Gauvin, Alan Poling
BACKGROUND: Levamisole (LVM) is a common adulterant in clandestinely manufactured cocaine (COC), with a range of well-documented deleterious health effects. Although the prevalence of LVM in COC has been widely noted, the subjective effects related to concomitant COC-LVM administration are poorly understood. AIMS: The present study sought to compare the subjective effects of LVM alone and in combination with COC in male and female Sprague-Dawley rats trained to discriminate COC from vehicle injections...
June 1, 2018: Journal of Psychopharmacology
Sean B Dolan, Ritu A Shetty, Michael J Forster, Michael B Gatch
BACKGROUND: Substituted piperazines comprise a substantial proportion of the novel psychoactive substance market. Among the most widely abused piperazine compounds are meta-chlorophenylpiperazine (mCPP), tri-fluoromethylphenylpiperazine (TFMPP), and, especially, benzylpiperazine (BZP), which are commonly incorporated, either alone or in combination, in illicit "party pills" or "ecstasy" formulations. Illicit synthesis of BZP often results in production of an impure by-product dibenzylpiperazine (DBZP), which frequently appears alongside BZP in these formulations; however, despite its ubiquity, little information exists regarding the abuse liability of DBZP...
July 2018: Journal of Psychopharmacology
Esther M Beraha, Elske Salemink, Erwin Krediet, Reinout W Wiers
BACKGROUND: Baclofen has shown promise in the treatment of alcohol dependence. However, its precise (neuro-) psychological working mechanism is still under debate. AIMS: This study aimed to get a better understanding of baclofen's working mechanism by examining the effect of baclofen on cognitive biases. It was hypothesized that baclofen, compared to placebo, would lead to weaker cognitive biases. Furthermore, given a suggested anxiolytic effect of baclofen, we expected that anxiety would moderate this effect...
June 1, 2018: Journal of Psychopharmacology
Kimberly Mercuri, Gill Terrett, Julie D Henry, H Valerie Curran, Morgan Elliott, Peter G Rendell
BACKGROUND: Cannabis use is associated with a range of neurocognitive deficits, including impaired episodic memory. However, no study to date has assessed whether these difficulties extend to episodic foresight, a core component of which is the ability to mentally travel into one's personal future. This is a particularly surprising omission given that episodic memory is considered to be critical to engage episodic foresight. AIMS: In the present study, we provide the first test of how episodic foresight is affected in the context of differing levels of cannabis use, and the degree to which performance on a measure of this construct is related to episodic memory...
June 1, 2018: Journal of Psychopharmacology
Radka Graf, Jami L Longo, Zoë A Hughes
Deficits in hippocampal-mediated pattern separation are one aspect of cognitive function affected in schizophrenia (SZ) or Alzheimer's disease (AD). To develop novel therapies, it is beneficial to explore this specific aspect of cognition preclinically. The location discrimination reversal (LDR) task is a hippocampal-dependent operant paradigm that evaluates spatial learning and cognitive flexibility using touchscreens. Here we assessed baseline performance as well as multimodal disease-relevant manipulations in mice...
June 1, 2018: Journal of Psychopharmacology
Mihaela Golic, Harald Aiff, Per-Ola Attman, Bernd Ramsauer, Staffan Schön, Jan Svedlund
BACKGROUND: Lithium has been used for more than 50 years and guidelines for treatment monitoring have been documented in Sweden since the beginning of the 1980s. AIMS: The aim of this study was to describe compliance over time with the Swedish guidelines for long-term lithium treatment. METHODS: The study material was obtained from Sahlgrenska University Hospital's laboratory database. We analysed data (serum lithium and serum creatinine) of adult patients treated with lithium between 1981 and 2010, and determined compliance with guidelines and serum lithium levels over time...
June 1, 2018: Journal of Psychopharmacology
Martin Le Nedelec, Paul Glue, Helen Winter, Chelsea Goulton, Natalie J Medlicott
BACKGROUND: Ketamine has been shown to produce a rapid and potent antidepressant response in patients with treatment-resistant depression. Currently ketamine is most commonly administered as a 40-minute intravenous infusion, though it is unknown whether this is the optimal route of administration. AIMS: To determine the plasma concentration time course of the R- and S-enantiomers of ketamine and norketamine following administration of ketamine by four different routes of administration...
June 1, 2018: Journal of Psychopharmacology
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