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Journal of Psychopharmacology

Fabrício Calvo, Bruno Lobão-Soares, Renato Leonardo de Freitas, Tatiana Paschoalin-Maurin, Tayllon Dos Anjos-Garcia, Priscila Medeiros, Juliana Almeida da Silva, Thelma Anderson Lovick, Norberto Cysne Coimbra
BACKGROUND: There is a controversy regarding the key role played by opioid peptide neurotransmission in the modulation of panic-attack-related responses. AIMS: Using a prey versus rattlesnakes paradigm, the present work investigated the involvement of the endogenous opioid peptide-mediated system of the inferior colliculus in the modulation of panic attack-related responses. METHODS: Wistar rats were pretreated with intracollicular administration of either physiological saline or naloxone at different concentrations and confronted with rattlesnakes ( Crotalus durissus terrificus)...
November 8, 2018: Journal of Psychopharmacology
Xueling Zhu, Shaohui Liu, Weihua Liao, Lingyu Kong, Canhua Jiang, Fulai Yuan
BACKGROUND: Betel quid is the fourth most popular psychoactive agent worldwide. Neuroimaging studies have suggested betel-quid dependence is accompanied by abnormality in brain structure and function. However, the neural correlates of executive function deficit and prefrontal cortical thickness associated with betel-quid chewing still remain unclear. OBJECTIVE: The present study aimed to examine the relationship between executive function deficit and prefrontal cortical thickness in chronic betel-quid chewers...
October 31, 2018: Journal of Psychopharmacology
Marcela Ot'alora G, Jim Grigsby, Bruce Poulter, Joseph W Van Derveer, Sara Gael Giron, Lisa Jerome, Allison A Feduccia, Scott Hamilton, Berra Yazar-Klosinski, Amy Emerson, Michael C Mithoefer, Rick Doblin
BACKGROUND: Posttraumatic stress disorder often does not resolve after conventional psychotherapies or pharmacotherapies. Pilot studies have reported that 3,4-methylenedioxymethamphetamine (MDMA) combined with psychotherapy reduces posttraumatic stress disorder symptoms. AIMS: This pilot dose response trial assessed efficacy and safety of MDMA-assisted psychotherapy across multiple therapy teams. METHODS: Twenty-eight people with chronic posttraumatic stress disorder were randomized in a double-blind dose response comparison of two active doses (100 and 125 mg) with a low dose (40 mg) of MDMA administered during eight-hour psychotherapy sessions...
October 29, 2018: Journal of Psychopharmacology
Jayashri Kulkarni, Natalie Thomas, Abdul-Rahman Hudaib, Emorfia Gavrilidis, Caroline Gurvich
BACKGROUND: Ondansetron is a serotonin 3 receptor antagonist widely used to prevent nausea and vomiting in pregnancy and in patients receiving chemotherapy. There is growing evidence that adjunctive ondansetron treatment improves symptomatology associated with schizophrenia, particularly with respect to the positive, negative and cognitive symptoms. Further studies that are applicable to real world practice are required to assess the efficacy and effectiveness of this treatment, which could be readily and rapidly translated into clinical practice...
October 25, 2018: Journal of Psychopharmacology
A Correas, E López-Caneda, L Beaton, S Rodríguez Holguín, L M García-Moreno, L F Antón-Toro, F Cadaveira, F Maestú, K Marinkovic
BACKGROUND: The prevalence of binge drinking has risen in recent years. It is associated with a range of neurocognitive deficits among adolescents and young emerging adults who are especially vulnerable to alcohol use. Attention is an essential dimension of executive functioning and attentional disturbances may be associated with hazardous drinking. The aim of the study was to examine the oscillatory neural dynamics of attentional control during visual target detection in emerging young adults as a function of binge drinking...
October 24, 2018: Journal of Psychopharmacology
Sarah Beggiato, Francesca M Notarangelo, Korrapati V Sathyasaikumar, Flaviano Giorgini, Robert Schwarcz
BACKGROUND: Several studies suggest a pathophysiologically relevant association between increased brain levels of the neuroinhibitory tryptophan metabolite kynurenic acid and cognitive dysfunctions in people with schizophrenia. Elevated kynurenic acid in schizophrenia may be secondary to a genetic alteration of kynurenine 3-monooxygenase, a pivotal enzyme in the kynurenine pathway of tryptophan degradation. In rats, prenatal exposure to kynurenine, the direct bioprecursor of kynurenic acid, induces cognitive impairments reminiscent of schizophrenia in adulthood, suggesting a developmental dimension to the link between kynurenic acid and schizophrenia...
October 24, 2018: Journal of Psychopharmacology
Maria Panagiotou, Mandy Meijer, Johanna H Meijer, Tom Deboer
BACKGROUND: Caffeine is one of the most widely consumed psychostimulants, and it impacts sleep and circadian physiology. AIM: Caffeine is generally used chronically on a daily basis. Therefore, in the current study, we investigated the chronic effect of caffeine on sleep in mice. METHODS: We recorded the electroencephalogram and electromyogram on a control day, on the first day of caffeine consumption (acute), and following two weeks of continuous caffeine consumption (chronic)...
October 24, 2018: Journal of Psychopharmacology
David Nutt, Trevor Robbins, Ann Hayes
No abstract text is available yet for this article.
October 24, 2018: Journal of Psychopharmacology
Mathieu Di Miceli, Adesina Omoloye, Benjamin Gronier
BACKGROUND: Psychostimulants like methylphenidate or D-amphetamine are often prescribed for attention deficit and hyperactivity disorders in children. Whether such drugs can be administered into a developing brain without consequences in adulthood is still an open question. METHODS: Here, using in vivo extracellular electrophysiology in anesthetised preparations, combined with behavioural assays, we have examined the long-term consequences in adulthood of a chronic methylphenidate oral administration (5 mg/kg/day, 15 days) in early adolescent (post-natal day 28) and late adolescent (post-natal day 42) rats, by evaluating body weight change, sucrose preference (indicator of anhedonia), locomotor sensitivity to D-amphetamine and electrical activities of ventral tegmental area dopamine and dorsal raphe nucleus serotonin neurons...
October 18, 2018: Journal of Psychopharmacology
Jun Gao, Ming Li
BACKGROUND: Antipsychotic treatment is effective in the treatment of psychosis, although it also brings with it some unwanted side effects and is associated with low compliance. Finding a non-pharmacological alternative for antipsychotic treatment is highly desirable. AIMS: This preclinical study examined the 'antipsychotic' efficacy of such a behavioral technique using a conditioned avoidance response model. This technique, termed reinforcement attenuation (RA), is to administer a brief footshock (0...
October 18, 2018: Journal of Psychopharmacology
Francisco J Flores-Ramirez, Israel Garcia-Carachure, David O Sanchez, Celene Gonzalez, Samuel A Castillo, Miguel A Arenivar, Anapaula Themann, Omar Lira, Minerva Rodriguez, Joshua Preciado-Piña, Sergio D Iñiguez
BACKGROUND: Preclinical evidence from male subjects indicates that exposure to psychotropic medications, during early development, results in long-lasting altered responses to reward-related stimuli. However, it is not known if exposure to the antidepressant fluoxetine, in female subjects specifically, changes sensitivity to natural and drug rewards, later in life. AIMS: The aim of this work was to investigate if exposure to fluoxetine mediates enduring changes in sensitivity to the rewarding properties of cocaine and sucrose, using female mice as a model system...
October 18, 2018: Journal of Psychopharmacology
O Dzahini, N Singh, D Taylor, P M Haddad
OBJECTIVES: The purpose of this study was to investigate the association of antipsychotic exposure to the incidence and mortality of pneumonia. METHODS: The design of this study involved meta-analysis of observational studies identified from electronic databases. RESULTS: In total, 19 studies were included in the systematic review and 14 in the meta-analysis. Risk of pneumonia was increased by first-generation antipsychotics (risk ratio 1...
October 18, 2018: Journal of Psychopharmacology
Sarah A Grainger, Julie D Henry, Henriette R Steinvik, Eric J Vanman
BACKGROUND: Oxytocin is a neuropeptide involved in a range of social processes, and prior research has shown that intranasal oxytocin (iOT) may enhance trusting behaviors. However, it is unclear whether iOT influences perceptions of whether a face is trustworthy. In addition, no studies in this literature have investigated whether the participant's age may play a moderating role in the effects of iOT on trust. AIMS: We aimed to examine for the first time whether iOT influences perceptions of facial trustworthiness and eye-gaze patterns and, if so, whether age moderates these iOT effects...
October 17, 2018: Journal of Psychopharmacology
Borja Santos, Eduardo González-Fraile, Arantzazu Zabala, Virginia Guillén, José R Rueda, Javier Ballesteros
BACKGROUND: Schizophrenia is a severe, persistent mental disorder, and a leading cause of disability worldwide. Cognitive impairments presented in schizophrenia lead to a worse prognostic, thus treatments targeted to enhance cognition in schizophrenia may be clinically relevant. AIMS: The purpose of this study was to assess the efficacy of acetylcholinesterase inhibitors as add-on medication to antipsychotics on cognition in patients with schizophrenia. METHODS: Search strategies were developed for Medline, Embase and Cochrane Central Register of Controlled Trials, and are current to March 2018...
October 16, 2018: Journal of Psychopharmacology
Adrián Viudez-Martínez, María S García-Gutiérrez, Jorge Manzanares
BACKGROUND: Research interest has grown around the potential therapeutic use of cannabidiol in mood-related disorders, due to its anxiolytic and antidepressant-like effects. These have been partially attributed to its action as an allosteric modulator of 5-HTR1A. However, the exact mechanism supporting cannabidiol properties remains unclear. AIMS: To assess the effects of cannabidiol on different targets of the hypothalamus-pituitary-adrenal axis under baseline and stress conditions...
October 16, 2018: Journal of Psychopharmacology
Mark Moss, Ellen Smith, Matthew Milner, Jemma McCready
BACKGROUND: The use of herbal extracts and supplements to enhance health and wellbeing is increasing in western society. AIMS: This study investigated the impact of the acute ingestion of a commercially available water containing an extract and hydrolat of rosemary ( Rosmarinus officinalis L. syn. Salvia rosmarinus Schleid.). Aspects of cognitive functioning, mood and cerebrovascular response measured by near-infrared spectroscopy provided the dependent variables...
October 15, 2018: Journal of Psychopharmacology
Lawrence P Carter, Jack E Henningfield, Y Grace Wang, Yuan Lu, Debra Kelsh, Bradley Vince, Edward Sellers
BACKGROUND: This study evaluated the human abuse potential of solriamfetol (formerly JZP-110), a selective dopamine and norepinephrine reuptake inhibitor with robust wake-promoting effects. METHODS: Adults with a recent history of recreational polydrug use, including stimulants, and who met criteria in a Qualification Phase were randomized to one of six sequences in a Test Phase. Each Test Phase sequence included a single administration of placebo, solriamfetol (300, 600, and 1200 mg), and phentermine (45 and 90 mg), with a two-day washout between periods...
October 1, 2018: Journal of Psychopharmacology
Maarten Timmers, Paulien Ravenstijn, Liwen Xi, Gallen Triana-Baltzer, Maura Furey, Sandy Van Hemelryck, Jeike Biewenga, Marc Ceusters, Anindya Bhattacharya, Maarten van den Boer, Luc van Nueten, Peter de Boer
BACKGROUND: Central nervous system-derived interleukin-1β plays a role in mood disorders. P2X7 receptor activation by adenosine-triphosphate leads to the release of interleukin-1β. AIMS: This first-in-human study evaluated safety, tolerability, pharmacokinetics and pharmacodynamics of a novel central nervous system-penetrant P2X7 receptor antagonist, JNJ-54175446, in healthy participants. METHODS: The study had three parts: an ascending-dose study in fasted participants (0...
September 27, 2018: Journal of Psychopharmacology
Yanling Zhou, Wei Zheng, Weijian Liu, Chengyu Wang, Yanni Zhan, Hanqiu Li, Lijian Chen, Mingding Li, Yuping Ning
BACKGROUND: Ketamine has proven to have rapid, robust antidepressant effects on treatment-resistant depression. However, whether repeated ketamine infusions would cause short-and long-term neurocognitive impairments was not clear. Our aims were to investigate the neurocognitive effects of six ketamine infusions and to examine the association between these infusions and the antidepressant response in patients with unipolar and bipolar depression. METHODS: Six intravenous infusions of ketamine (0...
September 27, 2018: Journal of Psychopharmacology
Gracie L Hay, Sarah J Baracz, Nicholas A Everett, Jessica Roberts, Priscila A Costa, Jonathon C Arnold, Iain S McGregor, Jennifer L Cornish
BACKGROUND: Methamphetamine is an addictive stimulant that can cause many adverse physical, psychological and psychosocial effects. Preliminary evidence shows cannabidiol, a non-intoxicating constituent of the cannabis plant, may have efficacy in treating opioid and nicotine dependence. However, no study has yet examined whether cannabidiol treatment might impact on methamphetamine addiction. AIMS: The current study investigated whether cannabidiol administration reduces the motivation to self-administer methamphetamine and relapse to methamphetamine-seeking behavior following abstinence...
September 27, 2018: Journal of Psychopharmacology
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