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Journal of Psychopharmacology

Giouliana Kadra, Athan Spiros, Hitesh Shetty, Ehtesham Iqbal, Richard D Hayes, Robert Stewart, Hugo Geerts
BACKGROUND: Computer-modelling approaches have the potential to predict the interactions between different antipsychotics and provide guidance for polypharmacy. AIMS: To evaluate the accuracy of the quantitative systems pharmacology platform to predict parkinsonism side-effects in patients prescribed antipsychotic polypharmacy. METHODS: Using anonymized data from South London and Maudsley NHS Foundation Trust electronic health records we applied quantitative systems pharmacology, a neurophysiology-based computer model of humanized neuronal circuits, to predict the risk for parkinsonism symptoms in patients with schizophrenia prescribed two concomitant antipsychotics...
September 20, 2018: Journal of Psychopharmacology
Pra Heckman, A Blokland, A Sambeth
BACKGROUND: Animal literature suggests an interaction between acetylcholine and serotonin on cognitive functions. AIMS: The aim of the current study was to assess whether both neurotransmitters interact during memory and novelty processing in humans. METHODS: We tested the interaction between acetylcholine and serotonin on cognitive functions in healthy volunteers by means of treatment with rivastigmine and citalopram, respectively. RESULTS: The main result of the study showed that during the verbal learning task participants significantly recalled fewer words after citalopram treatment than after rivastigmine or placebo during both the immediate and delayed recall tasks...
September 18, 2018: Journal of Psychopharmacology
Hai-Quyen Tran, Se J Park, Eun-Joo Shin, The-Vinh Tran, Naveen Sharma, Yu J Lee, Ji H Jeong, Choon-Gon Jang, Dae-Joong Kim, Toshitaka Nabeshima, Hyoung-Chun Kim
BACKGROUND: Oxidative stress and mitochondrial dysfunction have been implicated in the pathophysiology of schizophrenia. AIMS: We investigated whether antipsychotic clozapine modulates nicotinamide adenine dinucleotide phosphate oxidase and mitochondrial burdens induced by phencyclidine in mice. METHODS: We examined the effect of clozapine on nicotinamide adenine dinucleotide phosphate oxidase activation, mitochondrial burdens (i.e. oxidative stress and mitochondrial dysfunction), and activities of enzymatic antioxidant in the prefrontal cortex, and subsequent abnormal behaviors induced by repeated treatment with phencyclidine...
September 12, 2018: Journal of Psychopharmacology
Rejish K Thomas, Glen Baker, John Lind, Serdar Dursun
BACKGROUND: Intravenous ketamine has been established as an efficacious and safe treatment, with transient effect, for treatment-resistant depression. However, the effectiveness of intravenous ketamine in non-research settings and with ultraresistant depression patients remains understudied. AIMS: This study aims to measure the response and remission rates in ultraresistant depression patients in a clinical setting by means of a retrospective, open label, database study...
September 5, 2018: Journal of Psychopharmacology
James B Leonard, Bruce Anderson, Wendy Klein-Schwartz
BACKGROUND: Lysergic acid diethylamide (LSD) and psilocybin are serotonergic hallucinogens that are used primarily for recreational abuse. Small studies evaluated the efficacy of LSD and psilocybin for several psychiatric conditions. There are limited safety or toxicity data for either of these substances, especially in large populations. METHODS: This was a retrospective analysis of single-substance exposures of LSD or psilocybin-containing mushrooms (PcMs) reported to United States poison centers from 1 January 2000 to 31 December 2016...
September 5, 2018: Journal of Psychopharmacology
Mariusz Papp, Piotr Gruca, Magdalena Lason, Katarzyna Tota-Glowczyk, Monika Niemczyk, Ewa Litwa, Paul Willner
BACKGROUND: A significant proportion of depressed patients fail to respond to treatment with antidepressant drugs. Such patients might nonetheless respond to deep brain stimulation of the prefrontal cortex. Deep brain stimulation has also been shown to normalize behaviour in the chronic mild stress (CMS) model of depression. However, these studies have involved animals that are in general treatment responsive. Thus, this is not the ideal situation in which to investigate how deep brain stimulation is effective where antidepressant drugs are not...
September 5, 2018: Journal of Psychopharmacology
Peter D van der Ark, Georg Golor, Luc van Nueten, Partha Nandy, Peter de Boer
BACKGROUND: Pharmacokinetics, pharmacodynamics and general safety and tolerability of JNJ-42847922, a selective orexin-2 receptor antagonist, were assessed in healthy subjects. METHODS: Five consecutive cohorts of healthy subjects were enrolled and received doses of 5-60 mg orally once daily over 10 days of JNJ-42847922 ( n=6) or placebo ( n=2). Concentrations of drug in plasma and urine were measured over 24 h after dosing on Days 1, 5 and 10. Observed- and self-reported somnolence was used to evaluate the principal pharmacodynamic effect of JNJ-42847922...
September 5, 2018: Journal of Psychopharmacology
Fang Shen, Keke Qi, Ying Duan, Yonghui Li, Jing Liang, Xiaolu Meng, Ming Li, Nan Sui
BACKGROUND: Anhedonia is a hallmark symptom in major depression that reflects deficits in hedonic capacity and it is also linked to motivation for reward. However, studies of the features of motivation in depressed tree shrews are rather sparse. AIMS: The study aimed to investigate the core feature of depression including lack of interest, motivation reduction, and social avoidance in tree shrews. Furthermore, the effects of the treatment using clomipramine on these depression-like behaviors were assessed...
September 5, 2018: Journal of Psychopharmacology
Bo Pan, Jiamei Lian, Chao Deng
BACKGROUND: Antipsychotics are developed to treat mental disorders in adults; however, the prescription (mostly "off-label") of antipsychotics for children/adolescents has been constantly increasing over years. The influences of antipsychotics on juveniles requires investigation to validate their clinic use. Antipsychotics mainly exert their effects via several receptors and signaling pathways. AIMS: This study examined the effects of aripiprazole, olanzapine, and risperidone on selected signaling pathways, N-methyl-D-aspartate, and γ-aminobutyric acid A receptors in juveniles...
August 23, 2018: Journal of Psychopharmacology
Peter S Bloomfield, David Bonsall, Lisa Wells, Dirk Dormann, Oliver Howes, Vincenzo De Paola
BACKGROUND: Altered microglial markers and morphology have been demonstrated in patients with schizophrenia in post-mortem and in vivo studies. However, it is unclear if changes are due to antipsychotic treatment. AIMS: Here we aimed to determine whether antipsychotic medication affects microglia in vivo. METHODS: To investigate this we administered two clinically relevant doses (0.05 mg n=12 and 2.5 mg n=7 slow-release pellets, placebo n=20) of haloperidol, over 2 weeks, to male Sprague Dawley rats to determine the effect on microglial cell density and morphology (area occupied by processes and microglial cell area)...
August 21, 2018: Journal of Psychopharmacology
Michael Cronquist Christensen, Ioana Florea, Annika Lindsten, David S Baldwin
BACKGROUND: Efficacy has been proven for vortioxetine in short-term and long-term treatment of major depressive disorder (MDD), with broad beneficial effects on emotional, physical and cognitive symptoms. Limited specific data on the effects of vortioxetine on depression-related physical symptoms have been published. METHODS: A meta-analysis was carried out of five short-term multinational, double-blind, placebo-controlled studies. These studies were conducted in a total of 2105 adult MDD outpatients (18-75 years) with a major depressive episode of ⩾3 months' duration...
July 26, 2018: Journal of Psychopharmacology
Julian Macoveanu, Kirsa M Demant, Maj Vinberg, Hartwig R Siebner, Lars V Kessing, Kamilla W Miskowiak
BACKGROUND: Cognitive deficits are prevalent in bipolar disorder during remission but effective cognition treatments are lacking due to insufficient insight into the neurobiological targets of cognitive improvement. Emerging data suggest that dorsal prefrontal cortex target engagement is a key neurocircuitry biomarker of pro-cognitive treatment effects. AIMS: In this randomized controlled functional magnetic resonance imaging study, we test this hypothesis by investigating the effects of an ineffective cognitive remediation intervention on dorsal prefrontal response during strategic memory encoding and working memory engagement...
July 1, 2018: Journal of Psychopharmacology
Mengbing Huang, Ming Bai, Zhimin Zhang, Lu Ge, Kang Lu, Xiang Li, Ye Li, Xiaoshuang Zhou, Ningning Guo, Lihua Yang, Jie Bai
BACKGROUND: Drug addiction is characterized by compulsive drug use and relapse. Thioredoxin-1 is emerging as an important modulator involved in the cellular protective response against a variety of toxic stressors. Previous study has reported that thioredoxin-1 overexpression prevents the acquisition of methamphetamine-conditioned place preference. Here, we aimed to investigate the effect of thioredoxin-1 on methamphetamine-conditioned place preference extinction and the possible mechanism...
September 2018: Journal of Psychopharmacology
Kiana Sadeghi-Ardekani, Mahmonir Haghighi, Rasoul Zarrin
BACKGROUND: Smoking-induced oxidative stress is thought to contribute to lower levels of omega-3 fatty acids in plasma and brain tissue. This lower level leads to impaired function in a dopaminergic system related to dependence and craving. AIMS: The aim of this study was to evaluate the effects of omega-3 fatty acid supplementation on cigarette craving and oxidative stress index in heavy-smoker males. METHODS: In this double-blind, randomized clinical trial, 54 heavy-smoker males (smoke ⩾20 cigarettes per day) were randomly selected to receive either five capsules of fish-oil-derived omega-3 fatty acid supplements ( n = 27, each 1 g capsule containing 180 mg of eicosapentaenoic acid and 120 mg of docosahexanoic acid) or a placebo ( n = 27) for 3 months...
September 2018: Journal of Psychopharmacology
Dan I Lubman, Joshua Bb Garfield, Stella M Gwini, Ali Cheetham, Sue M Cotton, Murat Yücel, Nicholas B Allen
BACKGROUND: Anhedonia is a commonly reported symptom among substance-dependent populations that appears to diminish with sustained abstinence. However, previous research has not determined whether anhedonia is dynamically linked to changing patterns of drug use, nor whether it predicts subsequent drug use. AIMS: We aimed to test whether changes in illicit opioid use would predict changes in anhedonia, and whether increases in anhedonia would predict further opioid use...
September 2018: Journal of Psychopharmacology
Chris Barkus, Jacqueline-Marie N Ferland, Wendy K Adams, Grant C Churchill, Philip J Cowen, David M Bannerman, Robert D Rogers, Catharine A Winstanley, Trevor Sharp
BACKGROUND: Deficits in impulse control feature in many psychiatric conditions including bipolar disorder, suicidality and addictions. Lithium lowers impulsivity in clinical populations and decreases pathological gambling in experimental medicine studies, but suffers from adverse effects, poor compliance and a low therapeutic index. AIMS: Recently we identified that the neuroprotective agent ebselen, which is reportedly safe in humans, inhibited inositol monophosphatase (IMPase), a candidate lithium mechanism...
September 2018: Journal of Psychopharmacology
Radka Graf, Jami L Longo, Zoë A Hughes
Deficits in hippocampal-mediated pattern separation are one aspect of cognitive function affected in schizophrenia (SZ) or Alzheimer's disease (AD). To develop novel therapies, it is beneficial to explore this specific aspect of cognition preclinically. The location discrimination reversal (LDR) task is a hippocampal-dependent operant paradigm that evaluates spatial learning and cognitive flexibility using touchscreens. Here we assessed baseline performance as well as multimodal disease-relevant manipulations in mice...
September 2018: Journal of Psychopharmacology
Gerald W Valentine, Elise E DeVito, Peter I Jatlow, Ralitza Gueorguieva, Mehmet Sofuoglu
OBJECTIVE: This double-blind, placebo controlled study examined whether menthol inhaled from an electronic cigarette (e-cigarette) would change subjective and withdrawal alleviating effects of intravenous nicotine in young adult smokers. METHODS: A total of 32 menthol-preferring smokers and 25 non-menthol-preferring smokers participated in the study that consisted of a random sequence of three different inhaled menthol conditions (0.0%, 0.5%, and 3.2%) across three test sessions (a single menthol condition per session)...
September 2018: Journal of Psychopharmacology
Matthew Clyde, Andrew Pipe, Charl Els, Robert Reid, Angel Fu, Alexa Clark, Heather Tulloch
INTRODUCTION: It has been suggested that the effectiveness of nicotine replacement smoking cessation pharmacotherapy may be enhanced by assessing rates of nicotine metabolism using the nicotine metabolite ratio - which reflects differences in the activity of the CYP2A6 hepatic enzyme - and titrating doses appropriately. To date, supporting evidence is equivocal, with little information regarding the assessment and effectiveness of the nicotine metabolite ratio among smokers with psychiatric conditions...
September 2018: Journal of Psychopharmacology
Terril L Verplaetse, Andrea H Weinberger, Rebecca L Ashare, Brian P Pittman, Julia M Shi, Jeanette M Tetrault, Meaghan Lavery, Sherry A McKee
INTRODUCTION: Separate α1- and β-adrenergic antagonists have shown efficacy in reducing nicotine-motivated behaviors in rodents and humans, supporting a role for the noradrenergic system in mediating the reinforcing properties of drugs of abuse. However, the effect of the combined α1- and β-adrenergic antagonist, carvedilol, on stress-related smoking is unknown. METHODS: Using a well-established human laboratory model of stress-precipitated smoking-lapse behavior, we examined whether carvedilol (0 or 50 mg/day; between subject, n=17 per group), administered to steady-state, would attenuate the ability to resist smoking following stress imagery (vs...
September 2018: Journal of Psychopharmacology
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