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Journal of Chemotherapy

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https://www.readbyqxmd.com/read/28728477/increased-rate-of-penicillin-non-susceptible-strains-of-n-meningitidis-in-naples-italy
#1
Giovanni Di Caprio, Novella Carannante, Mariano Bernardo, Susanna Cuccurullo, Carlo Pallotto, Carlo Tascini
Neisseria meningitidis is a causative agent of community-acquired sepsis and meningitis in humans. These diseases are associated with high mortality and morbidity if treatment is not started promptly. The empiric antibiotic treatment depends on patient factors and local epidemiology. In the past years, an increased number meningococcal strain with reduced susceptibility to penicillin has also been described. We analysed the susceptibility pattern of 11 N. meningitidis strains isolated between 2013 and 2016...
July 20, 2017: Journal of Chemotherapy
https://www.readbyqxmd.com/read/28697650/ceftaroline-for-the-treatment-of-osteomyelitis-caused-by-methicillin-resistant-staphylococcus-aureus-a-case-series
#2
Karineh Lalikian, Rita Parsiani, Regina Won, Eric Chang, R Brigg Turner
Despite limited clinical data, ceftaroline is commonly used for treatment of complicated, invasive infections caused by methicillin-resistant Staphylococcus aureus (MRSA). A retrospective chart review was conducted of adult patients receiving ceftaroline for MRSA osteomyelitis admitted between April 2011 and March 2016 at a five-hospital system. Twelve patients met the inclusion criteria. All patients received prior antimicrobial therapy with a median time to switch to ceftaroline of 45.5 days. Five of the 12 patients (41...
July 11, 2017: Journal of Chemotherapy
https://www.readbyqxmd.com/read/28697647/antimetabolites-in-the-treatment-of-advanced-pleural-mesothelioma-a-network-meta-analysis-of-randomized-clinical-trials
#3
Davide Tassinari, Chiara Cherubini, Emiliano Tamburini, Fabrizio Drudi, Maximilian Papi, Manuela Fantini, Luigi Lazzari-Agli, Sergio Sartori
An indirect comparison of cisplatin-pemetrexed (CP) and cisplatin-raltitrexed (CR) was performed. The Odds Ratios of 10, 15 and 20 month survival rate and response rate were assumed as indexes of efficacy; the Odds Ratio of grade III-IV side effects, and the absolute risk of overall, hematologic and non-hematologic toxicity, were assumed as indexes of safety. The outcomes of 352 patients were analysed. The Odds Ratios and 95% Confidence Interval (95% CI) of 10, 15 and 20 months survival rate and response rate were 1...
July 11, 2017: Journal of Chemotherapy
https://www.readbyqxmd.com/read/28651480/news-on-therapeutic-management-of-mdr-tuberculosis-a-literature-review
#4
Lucie Barthod, Jean-Guillaume Lopez, Christophe Curti, Charléric Bornet, Manon Roche, Marc Montana, Patrice Vanelle
In 2015, the World Health Organization registered 10.4 million people who developed tuberculosis worldwide and 480,000 new cases of multidrug-resistant tuberculosis were identified. The care of multi and extensively drug-resistant tuberculosis is based on a combination of pyrazinamide and second-line drugs. These regimens are lengthy, partially effective and poorly tolerated. The challenge is to re-evaluate the use of existing molecules and to develop new agents more effective against resistant strains with shorter treatment duration...
June 26, 2017: Journal of Chemotherapy
https://www.readbyqxmd.com/read/28641483/good-performance-of-platinum-based-chemotherapy-for-high-grade-gastroenteropancreatic-and-unknown-primary-neuroendocrine-neoplasms
#5
Giovanni Brandi, Marco Paragona, Davide Campana, Nicole Brighi, Arrigo Bondi, Maria Abbondanza Pantaleo, Jody Corbelli, Maria Aurelia Barbera, Guido Biasco
To evaluate efficacy and safety of platinum and etoposide combination in the treatment of advanced gastroenteropancreatic (GEP) and unknown primary (CUP) neuroendocrine carcinomas (NEC), we analysed the records of 21 consecutive patients treated with this regimen from 1999 to 2012. Objective responses were obtained in 11 patients (52%) and disease stability (DS) in 5 (24%). Median progression-free survival (PFS) was 7 months (95% CI, 5.33-8.66). Median overall survival (OS) was 16 months (95% CI, 14.97-17...
June 22, 2017: Journal of Chemotherapy
https://www.readbyqxmd.com/read/28622734/epidemiology-of-multidrug-resistant-acinetobacter-baumannii-strains-in-iran-a-systematic-review-and-meta-analysis
#6
Abed Zahedi Bialvaei, Ebrahim Kouhsari, Amin Salehi-Abargouei, Nour Amirmozafari, Rashid Ramazanzadeh, Ali Ghadimi-Daresajini, Mansour Sedighi
Acinetobacter baumannii is an important opportunistic pathogen that causes major public health concern especially in hospitalized patients due to the acquisition of multidrug resistance (MDR). The aim of this study was to systematically review published data about the prevalence rate of MDR-A. baumannii (MDR-AB) from different parts of Iran and provide an overall relative frequency (RF) using meta-analysis. All available national and international databanks were searched to find published studies up to June 2016...
June 16, 2017: Journal of Chemotherapy
https://www.readbyqxmd.com/read/28614982/intraventricular-administration-of-tigecycline-for-the-treatment-of-multidrug-resistant-bacterial-meningitis-after-craniotomy-a-case-report
#7
Yuanxing Wu, Kai Chen, Jingwei Zhao, Qiang Wang, Jianxin Zhou
BACKGROUND: Intracranial infections, especially multidrug-resistant (MDR) bacterial meningitis, are one of the most severe complications after craniotomy and may greatly impact patient outcomes. CASE PRESENTATION: We report a case of severe MDR Klebsiella pneumonia meningitis after craniotomy that was treated with three different dosages of tigecycline (Pfizer, New York, NY, U.S.A.)via a combined intravenous (IV) and intracerebroventricular (ICV) administration...
June 14, 2017: Journal of Chemotherapy
https://www.readbyqxmd.com/read/28587559/species-differences-in-ciprofloxacin-resistance-among-gram-negative-bacteria-can-anti-mutant-ratios-of-the-area-under-the-concentration-time-curve-to-the-mic-be-achieved-clinically
#8
Elena N Strukova, Yury A Portnoy, Stephen H Zinner, Alexander A Firsov
To explore if the 'anti-mutant' ratios of 24-h area under the concentration-time curve (AUC24) to the MIC overlap the clinically attainable AUC24/MICs, the selection of ciprofloxacin-resistant Escherichia coli, Pseudomonas aeruginosa and Klebsiella pneumoniae mutants was studied in dynamic model that simulates human pharmacokinetics of ciprofloxacin. Four strains each of E. coli and P. aeruginosa and three strains of K. pneumoniae were exposed to ciprofloxacin over a 50-400-fold range of the AUC24/MIC ratio...
June 6, 2017: Journal of Chemotherapy
https://www.readbyqxmd.com/read/28587526/optimal-teicoplanin-dosage-regimens-for-methicillin-resistant-staphylococcus-aureus-infections-in-endocarditis-patients-and-renal-failure-patients
#9
Na Li, Liqin Zhu, Gaoqi Xu, Tingyue Ge, Fang Qi, Mengxue Li
This study aimed to assess whether traditional initial loading and maintenance doses of teicoplanin were appropriate in endocarditis and renal failure patients with methicillin-resistant Staphylococcus aureus (MRSA) infections and to recommend optimal dosage regimens. Pharmacokinetic parameters and physicochemical properties of teicoplanin were performed to develop pharmacokinetic models using GastroPlus(TM). Concentration-time curves of teicoplanin in endocarditis and renal failure patients with MRSA infections were simulated by changing clearance (CL) and volume of distribution of the central compartment (Vc)...
June 6, 2017: Journal of Chemotherapy
https://www.readbyqxmd.com/read/28580878/optimizing-adherence-to-advice-from-antimicrobial-stewardship-audit-and-feedback-rounds
#10
Matthew D M Rawlins, Frank M Sanfilippo, Paul R Ingram, Duncan G J McLellan, Colin Crawford, Luca D'Orsogna, John Dyer
We examined adherence to antimicrobial stewardship prospective audit and feedback rounds in a rehabilitation service compared with the remainder of the acute hospital, and explored the reasons for this. Between October 2014 and December 2015, we retrospectively assessed the rate of non-adherence to advice from antimicrobial stewardship prospective audit and feedback rounds between the rehabilitation service and the acute hospital, along with the source of the patient referral. Compared with the rehabilitation service, acute hospital medical staff were almost twice as likely to not adhere to advice provided on antimicrobial stewardship prospective audit and feedback rounds (13...
June 5, 2017: Journal of Chemotherapy
https://www.readbyqxmd.com/read/28490252/visceral-leishamiosis-in-immunocompromised-host-an-update-and-literature-review
#11
Pasquale Pagliano, Silvano Esposito
Visceral leishmaniasis (VL) is a chronic infectious disease endemic in tropical and sub-tropical areas including the Mediterranean basin, caused by a group of protozoan parasites of the genus Leishmania and transmitted by phlebotomine sandflies. Immunocompromised patients, in particular HIV positive, are considered at risk of VL. They report atypical signs and poor response to treatment due to impairment of T-helper and regulatory cells activity. Laboratory diagnosis is based on microscopy on bone marrow or spleen aspirates...
May 10, 2017: Journal of Chemotherapy
https://www.readbyqxmd.com/read/28486840/molecular-characterization-of-carbapenem-resistant-enterobacteriaceae-yields-increasing-rates-of-ndm-1-carbapenemases-and-colistin-resistance-in-an-oxa-48-endemic-area
#12
Zeynep Cizmeci, Elif Aktas, Baris Otlu, Ozlem Acikgoz, Seyhan Ordekci
We aimed to characterize carbapenem-resistant isolates in a tertiary hospital in Istanbul, Turkey, high-prevelance area for OXA-48 producers. About 76 Enterobacteriaceae clinical isolates were included. Carbapenemase production was detected by Carbapenem Inactivation Method and carbapenemase genes were investigated by PCR. The clonal relationships were evaluated by AP-PCR. Nineteen Klebsiella pneumoniae isolates were colistin resistant. About 75 isolates yielded carbapenemase by CIM. 52 OXA-48, 17 NDM-1 and 2 VIM-5 carbapenemase genes were detected...
May 9, 2017: Journal of Chemotherapy
https://www.readbyqxmd.com/read/28482780/voriconazole-induced-hyponatraemia-associated-with-homozygous-cyp2c19-2-genotype
#13
Sharon Ho, Matthew Rawlins, Paul Ingram, Peter Boan
No abstract text is available yet for this article.
May 8, 2017: Journal of Chemotherapy
https://www.readbyqxmd.com/read/28378613/diagnosis-and-management-of-skin-and-soft-tissue-infections-ssti-a-literature-review-and-consensus-statement-an-update
#14
Silvano Esposito, Matteo Bassetti, Ercole Concia, Giuseppe De Simone, Francesco G De Rosa, Paolo Grossi, Andrea Novelli, Francesco Menichetti, Nicola Petrosillo, Marco Tinelli, Mario Tumbarello, Maurizio Sanguinetti, Pierluigi Viale, Mario Venditti, Claudio Viscoli
Skin and soft-tissue infections (SSTIs) are among the most common bacterial infections, posing considerable diagnostic and therapeutic challenges. Fourteen members of the Italian Society of Infectious Diseases, after a careful review of the most recent literature using Medline database and their own clinical experience, updated a previous paper published in 2011 by preparing a draught manuscript of the statements. The manuscript was successively reviewed by all members and ultimately re-formulated the present manuscript during a full day consensus meeting...
August 2017: Journal of Chemotherapy
https://www.readbyqxmd.com/read/28436299/mgmt-gene-variants-temozolomide-myelotoxicity-and-glioma-risk-a-concise-literature-survey-including-an-illustrative-case
#15
Meric A Altinoz, Ilhan Elmaci, Fatih Han Bolukbasi, Cumhur Gokhan Ekmekci, Guven Yenmis, Ramazan Sari, Aydin Sav
Temozolomide may cause thrombocytopenia or neutropenia in 3-4% of glioblastoma patients, respectively. However, pancytopenia is rarely reported. MGMT (O6-methylguanine-DNA-methyltransferase) enzyme repairs temozolomide-induced DNA mutations and associates both with antitumour efficacy and myelosuppression. Many studies on the effects of MGMT gene-methylation on temozolomide's effects exist, but much fewer publications concerning MGMT variants were documented. A full sequencing of the MGMT gene was performed in a female glioblastoma patient, who developed pancytopenia following temozolomide treatment...
April 23, 2017: Journal of Chemotherapy
https://www.readbyqxmd.com/read/28398176/septic-shock-due-to-nsti-caused-by-actinomyces-turicensis-the-role-of-clinical-pharmacology-case-report-and-review-of-the-literature
#16
Milo Gatti, Laura Elisa Gasparini, Chiara Maria Grimaldi, Daniela Abbati, Stefano Clemente, Paolo Riccardo Brioschi, Roberto Fumagalli, Francesco Scaglione
Critical septic patients affected by necrotizing soft tissue infections (NSTI) require an early, aggressive and multidisciplinary treatment. Pharmacokinetic alterations in antibiotic therapy are peculiar in these infections. Clinical pharmacology represents a first step in this setting. We report a case of septic shock due to NSTI in which clinical pharmacology is taken into account.
April 11, 2017: Journal of Chemotherapy
https://www.readbyqxmd.com/read/28398170/ipilimumab-in-real-world-clinical-practice-efficacy-and-safety-data-from-a-multicenter-observational-study
#17
Alberto Russi, Vera Damuzzo, Marco Chiumente, Jacopo Pigozzo, Marco Cesca, Vanna Chiarion-Sileni, Angelo Claudio Palozzo
In patients with metastatic melanoma, ipilimumab has been shown to improve long-term survival. This observational multicenter study reports clinical outcomes of 418 patients treated with second-line ipilimumab from February 2013 to August 2014. Median overall survival (OS) was 6.43 months (95%CI: 5.45-7.42; n = 300), while median progression-free survival (PFS) was 3.7 months (95%CI: 3.23-4.17; n = 188). Demographic factors, such as sex or number of previous therapies did not affect OS. Survival was shorter in patients with ECOG > 0 (Eastern Cooperative Oncology Group, Performance Status) (p < 0...
April 11, 2017: Journal of Chemotherapy
https://www.readbyqxmd.com/read/28110606/corrigendum
#18
(no author information available yet)
No abstract text is available yet for this article.
April 2017: Journal of Chemotherapy
https://www.readbyqxmd.com/read/28032528/chemotherapy-rechallenge-after-regorafenib-treatment-in-metastatic-colorectal-cancer-still-hope-after-the-last-hope
#19
Paola Bertocchi, Francesca Aroldi, Tiziana Prochilo, Fausto Meriggi, Giordano Domenico Beretta, Alberto Zaniboni
INTRODUCTION: The introduction of biological agents in cancer therapy is changing the progression of metastatic colorectal cancer. Currently, resistance to biological agents is an emerging problem; the progression of the disease is caused by the development of resistant clones. According to some authors, these clones can be re-sensitized to traditional and previously utilized chemotherapy agents. The results of the CORRECT study demonstrated the efficacy of regorafenib monotherapy in both KRAS wild type and mutant pretreated patients (pts)...
April 2017: Journal of Chemotherapy
https://www.readbyqxmd.com/read/27866454/the-role-of-thymidylate-synthase-in-non-small-cell-lung-cancer-treated-with-pemetrexed-continuation-maintenance-therapy
#20
Min Yang, Wei-Fei Fan, Xiao-Lin Pu, Li-Juan Meng, Jun Wang
Pemetrexed continuation maintenance therapy has been proven to be beneficial for patients with advanced non-squamous non-small cell lung cancer (NSCLC). However, the eligibility criteria for maintenance treatment are too simple. This study sought to evaluate thymidylate synthase (TS) as a predicting biomarker for pemetrexed continuation maintenance treatment in NSCLC. Specimens were collected from 87 patients treated with pemetrexed continuation maintenance therapy before and after four-cycle induction chemotherapy...
April 2017: Journal of Chemotherapy
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