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Journal of Chemotherapy

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https://www.readbyqxmd.com/read/28925824/can-we-go-for-a-shorter-treatment-course-in-chronic-hepatitis-c-more-inspiring-cases
#1
Rosa Zampino, Martina Vitrone, Antonio Parrella, Enrico Ragone, Emanuele Durante-Mangoni
Current interest in HCV therapy with direct acting antivirals is focused on shortening treatment length. We managed two cirrhotics who achieved virological cure after 4 weeks of ombitasvir/paritaprevir/ritonavir, dasabuvir, ribavirin treatment. Analysis to identify potential predictive factors for a successful outcome with a shorter treatment course was conducted.
September 19, 2017: Journal of Chemotherapy
https://www.readbyqxmd.com/read/28783005/piero-periti-review-article-award-2016the-editors-of-the-journal-of-chemotherapy-have-instituted-an-annual-award-in-the-memory-of-professor-piero-periti-see-photo-founder-of-the-journal-for-the-best-review-article-published-during-the-year-in-the-journal
#2
https://www.readbyqxmd.com/read/28728477/increased-rate-of-penicillin-non-susceptible-strains-of-n-meningitidis-in-naples-italy
#3
Giovanni Di Caprio, Novella Carannante, Mariano Bernardo, Susanna Cuccurullo, Carlo Pallotto, Carlo Tascini
Neisseria meningitidis is a causative agent of community-acquired sepsis and meningitis in humans. These diseases are associated with high mortality and morbidity if treatment is not started promptly. The empiric antibiotic treatment depends on patient factors and local epidemiology. In the past years, an increased number meningococcal strain with reduced susceptibility to penicillin has also been described. We analysed the susceptibility pattern of 11 N. meningitidis strains isolated between 2013 and 2016...
July 20, 2017: Journal of Chemotherapy
https://www.readbyqxmd.com/read/28697650/ceftaroline-for-the-treatment-of-osteomyelitis-caused-by-methicillin-resistant-staphylococcus-aureus-a-case-series
#4
Karineh Lalikian, Rita Parsiani, Regina Won, Eric Chang, R Brigg Turner
Despite limited clinical data, ceftaroline is commonly used for treatment of complicated, invasive infections caused by methicillin-resistant Staphylococcus aureus (MRSA). A retrospective chart review was conducted of adult patients receiving ceftaroline for MRSA osteomyelitis admitted between April 2011 and March 2016 at a five-hospital system. Twelve patients met the inclusion criteria. All patients received prior antimicrobial therapy with a median time to switch to ceftaroline of 45.5 days. Five of the 12 patients (41...
July 11, 2017: Journal of Chemotherapy
https://www.readbyqxmd.com/read/28697647/antimetabolites-in-the-treatment-of-advanced-pleural-mesothelioma-a-network-meta-analysis-of-randomized-clinical-trials
#5
Davide Tassinari, Chiara Cherubini, Emiliano Tamburini, Fabrizio Drudi, Maximilian Papi, Manuela Fantini, Luigi Lazzari-Agli, Sergio Sartori
An indirect comparison of cisplatin-pemetrexed (CP) and cisplatin-raltitrexed (CR) was performed. The Odds Ratios of 10, 15 and 20 month survival rate and response rate were assumed as indexes of efficacy; the Odds Ratio of grade III-IV side effects, and the absolute risk of overall, hematologic and non-hematologic toxicity, were assumed as indexes of safety. The outcomes of 352 patients were analysed. The Odds Ratios and 95% Confidence Interval (95% CI) of 10, 15 and 20 months survival rate and response rate were 1...
July 11, 2017: Journal of Chemotherapy
https://www.readbyqxmd.com/read/28378613/diagnosis-and-management-of-skin-and-soft-tissue-infections-ssti-a-literature-review-and-consensus-statement-an-update
#6
Silvano Esposito, Matteo Bassetti, Ercole Concia, Giuseppe De Simone, Francesco G De Rosa, Paolo Grossi, Andrea Novelli, Francesco Menichetti, Nicola Petrosillo, Marco Tinelli, Mario Tumbarello, Maurizio Sanguinetti, Pierluigi Viale, Mario Venditti, Claudio Viscoli
Skin and soft-tissue infections (SSTIs) are among the most common bacterial infections, posing considerable diagnostic and therapeutic challenges. Fourteen members of the Italian Society of Infectious Diseases, after a careful review of the most recent literature using Medline database and their own clinical experience, updated a previous paper published in 2011 by preparing a draught manuscript of the statements. The manuscript was successively reviewed by all members and ultimately re-formulated the present manuscript during a full day consensus meeting...
August 2017: Journal of Chemotherapy
https://www.readbyqxmd.com/read/28120698/short-course-daptomycin-lock-and-systemic-therapy-for-catheter-related-bloodstream-infections-a-retrospective-cohort-study-in-cancer-patients-with-surgically-implanted-devices
#7
Matteo Vassallo, Pierre-Luc Genillier, Brigitte Dunais, Regis Kaphan, Laurence Saudes, Yannick Duval, Fabien Rolland, Valerie Jullien, Nicolas Weiss, Elea Blanchouin, Annick Boscagli, Christophe Perrin, Nathalie Montagne
PURPOSE: Few in vivo studies have been reported describing efficacy and duration of antibiotic lock therapy (ALT) with daptomycin (DPT) for long-term catheter-related bloodstream infections (CRBSI) due to coagulase-negative staphylococci (CoNS). We retrospectively analysed the efficacy of short-course ALT with DPT in combination with systemic treatment (ST) for CoNS-associated CRBSI in our hospital. METHODS: Patients admitted for CoNS-associated CRBSI and treated with DPT as ALT and ST were retrospectively analysed...
August 2017: Journal of Chemotherapy
https://www.readbyqxmd.com/read/28651480/news-on-therapeutic-management-of-mdr-tuberculosis-a-literature-review
#8
Lucie Barthod, Jean-Guillaume Lopez, Christophe Curti, Charléric Bornet, Manon Roche, Marc Montana, Patrice Vanelle
In 2015, the World Health Organization registered 10.4 million people who developed tuberculosis worldwide and 480,000 new cases of multidrug-resistant tuberculosis were identified. The care of multi and extensively drug-resistant tuberculosis is based on a combination of pyrazinamide and second-line drugs. These regimens are lengthy, partially effective and poorly tolerated. The challenge is to re-evaluate the use of existing molecules and to develop new agents more effective against resistant strains with shorter treatment duration...
June 26, 2017: Journal of Chemotherapy
https://www.readbyqxmd.com/read/28641483/good-performance-of-platinum-based-chemotherapy-for-high-grade-gastroenteropancreatic-and-unknown-primary-neuroendocrine-neoplasms
#9
Giovanni Brandi, Marco Paragona, Davide Campana, Nicole Brighi, Arrigo Bondi, Maria Abbondanza Pantaleo, Jody Corbelli, Maria Aurelia Barbera, Guido Biasco
To evaluate efficacy and safety of platinum and etoposide combination in the treatment of advanced gastroenteropancreatic (GEP) and unknown primary (CUP) neuroendocrine carcinomas (NEC), we analysed the records of 21 consecutive patients treated with this regimen from 1999 to 2012. Objective responses were obtained in 11 patients (52%) and disease stability (DS) in 5 (24%). Median progression-free survival (PFS) was 7 months (95% CI, 5.33-8.66). Median overall survival (OS) was 16 months (95% CI, 14.97-17...
June 22, 2017: Journal of Chemotherapy
https://www.readbyqxmd.com/read/28622734/epidemiology-of-multidrug-resistant-acinetobacter-baumannii-strains-in-iran-a-systematic-review-and-meta-analysis
#10
Abed Zahedi Bialvaei, Ebrahim Kouhsari, Amin Salehi-Abargouei, Nour Amirmozafari, Rashid Ramazanzadeh, Ali Ghadimi-Daresajini, Mansour Sedighi
Acinetobacter baumannii is an important opportunistic pathogen that causes major public health concern especially in hospitalized patients due to the acquisition of multidrug resistance (MDR). The aim of this study was to systematically review published data about the prevalence rate of MDR-A. baumannii (MDR-AB) from different parts of Iran and provide an overall relative frequency (RF) using meta-analysis. All available national and international databanks were searched to find published studies up to June 2016...
June 16, 2017: Journal of Chemotherapy
https://www.readbyqxmd.com/read/28614982/intraventricular-administration-of-tigecycline-for-the-treatment-of-multidrug-resistant-bacterial-meningitis-after-craniotomy-a-case-report
#11
Yuanxing Wu, Kai Chen, Jingwei Zhao, Qiang Wang, Jianxin Zhou
BACKGROUND: Intracranial infections, especially multidrug-resistant (MDR) bacterial meningitis, are one of the most severe complications after craniotomy and may greatly impact patient outcomes. CASE PRESENTATION: We report a case of severe MDR Klebsiella pneumonia meningitis after craniotomy that was treated with three different dosages of tigecycline (Pfizer, New York, NY, U.S.A.)via a combined intravenous (IV) and intracerebroventricular (ICV) administration...
June 14, 2017: Journal of Chemotherapy
https://www.readbyqxmd.com/read/28587559/species-differences-in-ciprofloxacin-resistance-among-gram-negative-bacteria-can-anti-mutant-ratios-of-the-area-under-the-concentration-time-curve-to-the-mic-be-achieved-clinically
#12
Elena N Strukova, Yury A Portnoy, Stephen H Zinner, Alexander A Firsov
To explore if the 'anti-mutant' ratios of 24-h area under the concentration-time curve (AUC24) to the MIC overlap the clinically attainable AUC24/MICs, the selection of ciprofloxacin-resistant Escherichia coli, Pseudomonas aeruginosa and Klebsiella pneumoniae mutants was studied in dynamic model that simulates human pharmacokinetics of ciprofloxacin. Four strains each of E. coli and P. aeruginosa and three strains of K. pneumoniae were exposed to ciprofloxacin over a 50-400-fold range of the AUC24/MIC ratio...
June 6, 2017: Journal of Chemotherapy
https://www.readbyqxmd.com/read/28587526/optimal-teicoplanin-dosage-regimens-for-methicillin-resistant-staphylococcus-aureus-infections-in-endocarditis-patients-and-renal-failure-patients
#13
Na Li, Liqin Zhu, Gaoqi Xu, Tingyue Ge, Fang Qi, Mengxue Li
This study aimed to assess whether traditional initial loading and maintenance doses of teicoplanin were appropriate in endocarditis and renal failure patients with methicillin-resistant Staphylococcus aureus (MRSA) infections and to recommend optimal dosage regimens. Pharmacokinetic parameters and physicochemical properties of teicoplanin were performed to develop pharmacokinetic models using GastroPlus(TM). Concentration-time curves of teicoplanin in endocarditis and renal failure patients with MRSA infections were simulated by changing clearance (CL) and volume of distribution of the central compartment (Vc)...
June 6, 2017: Journal of Chemotherapy
https://www.readbyqxmd.com/read/28580878/optimizing-adherence-to-advice-from-antimicrobial-stewardship-audit-and-feedback-rounds
#14
Matthew D M Rawlins, Frank M Sanfilippo, Paul R Ingram, Duncan G J McLellan, Colin Crawford, Luca D'Orsogna, John Dyer
We examined adherence to antimicrobial stewardship prospective audit and feedback rounds in a rehabilitation service compared with the remainder of the acute hospital, and explored the reasons for this. Between October 2014 and December 2015, we retrospectively assessed the rate of non-adherence to advice from antimicrobial stewardship prospective audit and feedback rounds between the rehabilitation service and the acute hospital, along with the source of the patient referral. Compared with the rehabilitation service, acute hospital medical staff were almost twice as likely to not adhere to advice provided on antimicrobial stewardship prospective audit and feedback rounds (13...
June 5, 2017: Journal of Chemotherapy
https://www.readbyqxmd.com/read/28335692/liposomal-amphotericin-b-ambisome%C3%A2-at-beginning-of-its-third-decade-of-clinical-use
#15
REVIEW
Franco Aversa, Alessandro Busca, Anna Candoni, Simone Cesaro, Corrado Girmenia, Mario Luppi, Anna Maria Nosari, Livio Pagano, Luigina Romani, Giuseppe Rossi, Adriano Venditti, Andrea Novelli
Haematologists have been using liposomal amphotericin-B (L-AMB) since 1993 and despite the introduction of several novel antifungal agents over the past decade, their propensity to prescribe L-AMB remains unchanged. Although antifungal guidelines strongly recommend voriconazole as the drug of choice in the treatment of probable and proven invasive fungal disease (IFD), L-AMB is widely used in the real life because of its several advantages in terms of wide anti-mould spectrum, tolerability and efficacy. Furthermore, the concept that L-AMB is endowed with immune-modulating effects, which may have a role in fighting IFD, represent another reason for its use in patients who do not tolerate an excess of inflammation...
June 2017: Journal of Chemotherapy
https://www.readbyqxmd.com/read/28102109/epigenetic-regulation-of-rgs2-regulator-of-g-protein-signaling-2-in-chemoresistant-ovarian-cancer-cells
#16
Ercan Cacan
Regulator of G-protein signaling 2 (RGS2) is a GTPase-activating protein functioning as an inhibitor of G-protein coupled receptors (GPCRs). RGS2 dysregulation was implicated in solid tumour development and RGS2 downregulation has been reported in prostate and ovarian cancer progression. However, the molecular mechanism by which RGS2 expression is suppressed in ovarian cancer remains unknown. The expression and epigenetic regulation of RGS2 in chemosensitive and chemoresistant ovarian cancer cells were determined by qRT-PCR and chromatin immunoprecipitation assays, respectively...
June 2017: Journal of Chemotherapy
https://www.readbyqxmd.com/read/28067150/low-dose-5-fluorouracil-sensitizes-hepg2-cells-to-trail-through-trail-receptor-dr5-and-survivin-dependent-mechanisms
#17
Lijun Yang, Yutao Wang, Haifeng Zheng, Dong Zhang, Xiangwei Wu, Gongqin Sun, Tao Yang
Tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) is a promising candidate for cancer treatment due to its highly selective apoptosis-inducing action on tumour cells without harming normal cells. However, because of TRAIL resistance by some cancer cells, combined treatment with sensitizing agents is required to enhance the anticancer potential of TRAIL. In the present study, we investigated the sensitizing effect of 5-fluorouracil (5-FU) on TRAIL-induced apoptosis in TRAIL-resistant HepG2 hepatocarcinoma cells...
June 2017: Journal of Chemotherapy
https://www.readbyqxmd.com/read/27443547/carbapenem-inactivation-a-very-affordable-and-highly-specific-method-for-phenotypic-detection-of-carbapenemase-producing-pseudomonas-aeruginosa-isolates-compared-with-other-methods
#18
MULTICENTER STUDY
Mohammad Taghi Akhi, Younes Khalili, Reza Ghotaslou, Hossein Samadi Kafil, Saber Yousefi, Behroz Nagili, Hamid Reza Goli
This investigation was undertaken to compare phenotypic and molecular methods for detection of carbapenemase-producing Pseudomonas aeruginosa. A total of 245 non-duplicated isolates of P. aeruginosa were collected from hospitalized patients. Disc diffusion method was used to identify carbapenem-resistant bacteria. Three phenotypic methods, including Modified Hodge Test (MHT), Modified Carba NP (MCNP) test and Carbapenem Inactivation Method (CIM) were used for investigation of carbapenemase production. In addition, polymerase chain reaction (PCR) was used to detect carbapenemase encoding genes...
June 2017: Journal of Chemotherapy
https://www.readbyqxmd.com/read/27439026/cell-wall-composition-and-biofilm-formation-of-azoles-susceptible-and-resistant-candida-glabrata-strains
#19
COMPARATIVE STUDY
Alberto Vitali, Elisabetta Vavala, Valeria Marzano, Claudia Leone, Massimo Castagnola, Federica Iavarone, Letizia Angiolella
In the present study, three strains of Candida glabrata have been investigated to shed light on the mechanisms involved in azole resistance during adherence and biofilm formation. In particular, a clinical isolate, susceptible to azole-based drugs, DSY562 and two different resistant mutagenic strains deriving from DSY562, SFY114 and SFY115, have been analysed with different approaches for their cell wall composition and properties. A proteomic analysis revealed that the expression of six cell wall-related proteins and biofilm formation varied between the strains...
June 2017: Journal of Chemotherapy
https://www.readbyqxmd.com/read/27376439/deep-tissue-biopsy-vs-superficial-swab-culture-including-microbial-loading-determination-in-the-microbiological-assessment-of-skin-and-soft-tissue-infections-sstis
#20
COMPARATIVE STUDY
Silvano Esposito, Giuseppe De Simone, Renato Gioia, Silvana Noviello, Domenico Pagliara, Nicola Campitiello, Corrado Rubino, Dante Lo Pardo, Giovanni Boccia, Francesco De Caro, Tiziana Ascione
Thirty-two patients affected by SSTIs including DFIs were enrolled between 2013 and 2014. Superficial swab was obtained before and after cleansing with sterile saline, and after ultrasonic debridement; deep tissue biopsy was obtained from ulcer base. Samples were diluted with 1 mL of saline, serial 10-fold dilutions to 10(-6) were made and 50 μL of each dilution was plated onto appropriate media. Bacteria were identified by Vitek II system. Microbial load was expressed as CFU/mL. Statistical analysis was performed by χ2...
June 2017: Journal of Chemotherapy
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