journal
MENU ▼
Read by QxMD icon Read
search

Journal of Chemotherapy

journal
https://www.readbyqxmd.com/read/30025501/poor-in-vivo-efficacy-of-caspofungin-micafungin-and-amphotericin-b-against-wild-type-candida-krusei-clinical-isolates-does-not-correlate-with-in-vitro-susceptibility-results
#1
Tamás Kardos, Renátó Kovács, Gábor Kardos, Istvan Varga, Aliz Bozó, Zoltán Tóth, Fruzsina Nagy, László Majoros
We determined micafungin, caspofungin and amphotericin B (AMB) minimum inhibitory concentration (MICs) and killing rates in RPMI-1640 and in RPMI-1640 with 50% serum against three Candida krusei bloodstream isolates. MIC ranges in RPMI-1640 were 0.125-0.25, 0.25 and 0.125-0.5 mg/L, in RPMI-1640 with 50% serum, MICs were 64-128-, 8- and 4-16-fold higher, respectively. In RPMI-1640 micafungin and caspofungin at 1, 4, 16 and 32 mg/L as well as AMB at 2 mg/L were fungicidal against all isolates in ≤3.96, ≤4...
July 20, 2018: Journal of Chemotherapy
https://www.readbyqxmd.com/read/30025492/vinorelbine-s-anti-tumor-actions-may-depend-on-the-mitotic-apoptosis-autophagy-and-inflammation-hypotheses-with-implications-for-chemo-immunotherapy-of-advanced-cancers-and-pediatric-gliomas
#2
Meric A Altinoz, Aysel Ozpinar, Ebru Emekli Alturfan, Ilhan Elmaci
Vinorelbine is a very potent chemotherapeutic agent which is used to treat a number of cancers including breast and non-small cell lung tumors. Vinorelbine mainly acts via blocking microtubules and induces a specific type of cell death called 'mitotic catastrophe/apoptosis' subsequent to mitotic slippage, which is the failure of cells to stay in a mitotic arrested state and replicating their DNA without cytokinesis. Glial tumor cells are especially sensitive to mitotic slippage. In recent years, vinorelbine demonstrated potency in pediatric optic and pontine gliomas...
July 20, 2018: Journal of Chemotherapy
https://www.readbyqxmd.com/read/29943680/clinical-tools-for-chemotherapy-toxicity-prediction-and-survival-in-geriatric-cancer-patients
#3
Ioannis A Voutsadakis
Chemotherapy is one of the main treatments for cancer and is associated in many cancers with significant benefits in overall and disease-free survival. Nevertheless, it is also associated with adverse effects that make its administration difficult in patients with comorbidities or decreased general status. Older patients belong more often to these categories because of the physiologic effects of aging in organ functions but also because of longer effects of chronic conditions in different organs. As a result, the decision for administration of possibly beneficial chemotherapy to older patients becomes more problematic given that there is a requirement to balance this benefit with a higher probability of severe adverse effects that may even culminate to patient's demise...
June 26, 2018: Journal of Chemotherapy
https://www.readbyqxmd.com/read/29557289/susceptibility-of-escherichia-coli-to-nitroxoline-an-option-for-uncomplicated-urinary-tract-infections-the-first-report-from-croatia
#4
Ivana Mareković, Zrinka Bošnjak, Karla Jurić, Mario Ćorić, Sanja Popović-Grle
Nitroxoline (NTX), 5-nitro-8-hydroxyquinoline is an oral antibiotic with mechanism of bacteriostatic activity that is based on chelation of divalent cations required for bacterial RNA polymerase. Susceptibility to NTX of 100 Escherichia coli urine isolates was determined at the Department of Clinical and Molecular Microbiology, University Hospital Centre Zagreb during September and October 2017. Antimicrobial susceptibility was tested by disc diffusion and the results were interpreted according to the European Committee for Antimicrobial Susceptibility Testing (EUCAST) standards...
May 2018: Journal of Chemotherapy
https://www.readbyqxmd.com/read/29557272/early-abdominal-aortic-graft-infection-due-to-propionibacterium-acnes-a-case-report-and-review-of-the-literature
#5
Carlo Pallotto, Gioele Simonte, Fabio Verzini, Massimo Lenti, Franco Baldelli, Daniela Francisci, Maurizio Fiorio
Propionibacterium acnes is a member of the human microbiota that has been recently associated with late-onset infections of indwelling devices, especially shoulder prosthesis. Aortic graft infection are rare events with significant morbidity and mortality. Here, we describe the case of an abdominal aortic graft infection due to P. acnes with an unusual early onset. A review of the recent English language literature has been added.
May 2018: Journal of Chemotherapy
https://www.readbyqxmd.com/read/29431031/impact-of-cephalosporin-restriction-on-incidence-of-infections-with-extended-spectrum-beta-lactamase-producing-klebsiella-pneumoniae-in-an-endemic-setting
#6
Kristina Nadrah, Mateja Pirs, Samo Kreft, Manica Mueller Premru, Bojana Beovic
Decreasing cephalosporin use was described as an effective intervention in decreasing the incidence of infections caused by Klebsiella pneumoniae harbouring extended-spectrum beta-lactamase (ESBLKP). Due to sustained increased levels of infections caused by ESBLKP, a multifaceted antibiotic stewardship intervention aimed to decrease cephalosporin use was carried out at a large medical unit of a teaching hospital. All cephalosporins except the first-generation were restricted and could only be prescribed after authorization by an infectious disease physician...
May 2018: Journal of Chemotherapy
https://www.readbyqxmd.com/read/29405898/efficacy-and-safety-of-tigecycline-monotherapy-versus-combination-therapy-for-the-treatment-of-hospital-acquired-pneumonia-hap-a-meta-analysis-of-cohort-studies
#7
Xiang-Rong Bai, Jia-Ming Liu, De-Chun Jiang, Su-Ying Yan
The broad spectrum antibiotic tigecycline shows promising efficacy against many multiple drug resistant (MDR) pathogens. However, its clinical efficacy in the treatment of hospital-acquired pneumonia (HAP) is unclear. Several studies have reported on the treatment failures of tigecycline monotherapy, suggesting that it may not be sufficient to control severe infections. Combination therapy has become an option to treat MDR bacterial infections. We conducted a literature search using PubMed, Cochrane Library, Embase, Elsevier and the Web of Knowledge databases up to 29 February 2017 to identify relevant published studies...
May 2018: Journal of Chemotherapy
https://www.readbyqxmd.com/read/29385908/the-calm-before-the-storm-clinical-observations-of-middle-east-respiratory-syndrome-mers-patients
#8
Jaffar A Al-Tawfiq, Kareem Hinedi
BACKGROUND: Middle East Respiratory Syndrome Coronavirus (MERS-CoV) infection emerged in 2012. The majority of cases occurred in the Kingdom of Saudi Arabia and the disease carries a high case fatality rate. METHODS: We present three MERS-CoV cases and highlight the salient clinical features and laboratory, and radiographic characteristics. RESULTS: Although all nasopharyngeal samples were negative, MERS CoV infection was confirmed by reverse transcription-polymerase chain reaction of the E gene (UpE) and open reading frame (ORF1b) on sputum samples...
May 2018: Journal of Chemotherapy
https://www.readbyqxmd.com/read/29380676/the-current-role-of-glycopeptides-in-the-treatment-of-methicillin-resistant-staphylococcus-aureus-mrsa-infections-in-not-neutropenic-adults-the-viewpoint-of-a-group-of-italian-experts
#9
Ercole Concia, Claudio Viscoli, Valerio Del Bono, Maddalena Giannella, Matteo Bassetti, Giuseppe Francesco De Rosa, Emanuele Durante Mangoni, Silvano Esposito, Massimo Giusti, Paolo Grossi, Francesco Menichetti, Federico Pea, Nicola Petrosillo, Mario Tumbarello, Stefania Stefani, Mario Venditti, Pierluigi Viale
Staphylococcus aureus is still an important problem in clinical and therapeutic area, worldwide. In Italy, in recent years, methicillin resistance remained stable, yet considerably high, the percentage of strains of MRSA being around 40%. It was deemed interesting and timely to carry out a consensus conference using the RAND/UCLA method to collect the opinion of a group of experts in infectious diseases on the role of glycopeptides in the management of MRSA infections within several clinical scenarios and namely in pneumonia, bacteremia and endocarditis, joint replacement infections, skin and soft tissue infections, diabetic foot, abdominal infections and central nervous system infections...
May 2018: Journal of Chemotherapy
https://www.readbyqxmd.com/read/29336224/treatment-of-a-klebsiella-pneumoniae-kpc-cellulitis-and-gut-decolonization-with-ceftazidime-avibactam-in-a-migrant-from-libya
#10
Novella Carannante, Carlo Pallotto, Mariano Bernardo, Giovanni Di Caprio, Carlo Tascini
KPC-producing Klebsiella pneumoniae (KPC-Kp) is nowadays a global concern. Ceftazidime/avibactam is the most promising novel antibiotic combination available at the moment. We describe the case of a migrant with no risk factors for an infection due to multidrug resistant bacteria. He suffered from a KPC-Kp cellulitis and was treated with a ceftazidime/avibactam-meropenem-fosfomycin combination that not only eradicated the infection but also decontaminated his gut. Ceftazidime/avibactam-based treatment can be useful also in decontamination procedures...
May 2018: Journal of Chemotherapy
https://www.readbyqxmd.com/read/29304717/analysis-of-the-spectrum-and-antibiotic-resistance-of-uropathogens-in-outpatients-at-a-tertiary-hospital
#11
Bo Yang, Fujia Yang, Shanmei Wang, Qian Wang, Zhirui Liu, Wei Feng, Fengjun Sun, Peiyuan Xia
The objective of this study was to analyse the distribution and antimicrobial resistance of bacterial uropathogens isolated from outpatients at Henan Provincial People's Hospital. A total of 1419 samples from 823 newly diagnosed and 596 recurrent UTI outpatients culture positive. Escherichia coli was the most common uropathogen. Compared with the recurrent group, the newly diagnosed group had a higher isolation rate of E. coli and Enterobacter cloacae but a lower isolation rate of Klebsiella pneumoniae, Pseudomonas aeruginosa and Acinetobacter spp...
May 2018: Journal of Chemotherapy
https://www.readbyqxmd.com/read/29182058/prevalence-and-antimicrobial-susceptibility-of-ureaplasma-species-and-mycoplasma-hominis-in-greek-female-outpatients-2012-2016
#12
Sofia Maraki, Viktoria Eirini Mavromanolaki, Eleni Nioti, Dimitra Stafylaki, George Minadakis
Mycoplasma hominis and Ureaplasma species are opportunistic pathogens associated with urogenital infections, complications during pregnancy and postpartum infections. Appropriate empirical antimicrobial treatment is necessary to achieve an optimal therapeutic outcome. This study evaluated the prevalence and the antimicrobial susceptibility of Mycoplasma hominis and Ureaplasma spp. isolated from 1,008 endocervical samples of outpatients in Crete, Greece, during a five-year period (2012-2016), using the commercially available Mycoview kit (Zeakon diagnostics, France)...
May 2018: Journal of Chemotherapy
https://www.readbyqxmd.com/read/29168673/the-role-of-dalbavancin-in-the-multi-disciplinary-management-of-wound-infections-in-orthopaedic-surgery
#13
Fabio Arena, Emilio Romanini, Elia Rosi, Carlo Salomone, Gabriele Tucci, Ciro Pempinello, Massimo Fantoni
Antimicrobial resistance is continuously increasing among bacterial clinical isolates (especially methicillin resistance in Staphylococcus aureus, MRSA), negatively impacting on outcomes of patients with Surgical Site Infections (SSIs). A multi-disciplinary team work is essential for SSIs prevention and for the choice of antibiotic therapy of orthopaedic SSIs. In particular, an Antibiotic Stewardship (AS) approach is recommended for preserving the activity of old and new antimicrobials. Dalbavancin is a novel antimicrobial agent, belonging to the lipoglycopeptides family, recently approved by FDA for the treatment of ABSSSIs (Acute Bacterial Skin and Skin Structure Infections) and can be considered as a candidate for the treatment of orthopaedic superficial SSIs...
May 2018: Journal of Chemotherapy
https://www.readbyqxmd.com/read/29619901/inflammatory-biomarkers-to-guide-diagnostic-and-therapeutic-decisions-in-children-presenting-with-fever-without-apparent-source
#14
Giulia Trippella, Luisa Galli, Maurizio de Martino, Elena Chiappini
A systematic review of literature from 2011 to 2016 was performed, in order to evaluate the diagnostic performance of inflammatory biomarkers in children with fever without apparent source and their usefulness in clinical decision-making. Data source was the Pubmed database. Thirteen studies were included, analysing the following biomarkers: erythrocyte sedimentation rate, white blood count, absolute neutrophil count, C-reactive protein (CRP), procalcitonin (PCT), interleukin-6 (IL-6) and the Lab-score (a combination of CRP, PCT and urine dipstick)...
April 5, 2018: Journal of Chemotherapy
https://www.readbyqxmd.com/read/29191131/efficacy-of-ceftazidime-avibactam-in-a-rat-intra-abdominal-abscess-model-against-a-ceftazidime-and-meropenem-resistant-isolate-of-klebsiella-pneumoniae-carrying-bla-kpc-2
#15
Taryn Sleger, Eric Gangl, Petar Pop-Damkov, Kevin M Krause, Peter J Laud, Andrew M Slee, Wright W Nichols
Efficacies of ceftazidime-avibactam (4:1 w/w) and ceftazidime were tested against ceftazidime-susceptible (blaKPC-2 -negative), and meropenem- and ceftazidime-resistant (blaKPC-2 -positive), Klebsiella pneumoniae in a 52-h, multiple dose, abdominal abscess model in the rat. Efficacies corresponded to minimum inhibitory concentrations (MICs) measured in vitro and were consistent with drug exposures modelled from pharmacokinetics in infected animals. The ceftazidime, ceftazidime-avibactam and meropenem control treatments were effective in the rat abscess model against the susceptible strain, whereas only ceftazidime-avibactam was effective against K...
April 2018: Journal of Chemotherapy
https://www.readbyqxmd.com/read/29125052/prevalence-of-extended-spectrum-beta-lactamase-and-carbapenemase-producing-bloodstream-isolates-of-klebsiella-pneumoniae-in-a-tertiary-care-hospital
#16
Henrietta Abodakpi, Kai-Tai Chang, Ana María Sánchez Díaz, Rafael Cantón, Todd M Lasco, Katrina Chan, Amelia K Sofjan, Vincent H Tam
To improve prescribing of empiric therapy, the local molecular epidemiology of extended-spectrum beta-lactamases (ESBLs) and Klebsiella pneumoniae carbapenemases (KPCs) in bloodstream isolates of K. pneumoniae were evaluated. Isolates resistant to third generation cephalosporins were screened phenotypically for ESBLs and carbapenemases, and subsequently confirmed by PCR for the presence of ESBL (blaTEM , blaSHV and blaCTX-M ) and carbapenemase (blaKPC , blaVIM , blaNDM and blaOXA-48 ) genes. Hydrolytic activity (functional gene expression) was quantified using a nitrocefin degradation assay and correlated to ceftazidime or meropenem MIC...
April 2018: Journal of Chemotherapy
https://www.readbyqxmd.com/read/29108486/role-of-insertion-sequence-aba-1-and-ades-in-reduced-tigecycline-susceptibility-in-mdr-acinetobacter-baumannii-clinical-isolates-from-cairo-egypt
#17
Reem Hassan, Ahmed Mukhtar, Ahmed Hasanin, Doaa Ghaith
Infections caused by multidrug resistant (MDR) Acinetobacter baumannii (A. baumannii) especially in intensive care units have limited therapeutic options. Overexpression of the adeABC efflux pump may be caused either by the ISAba-1 insertion or by specific point mutations in adeR and adeS, therefore, plays a major role in conferring MDR-A. baumannii. We aimed in our study to monitor the tigecycline (TGC) susceptibility and to study the role of ISAba-1 and the adeS regulator within the AdeABC efflux pump among MDR-A...
April 2018: Journal of Chemotherapy
https://www.readbyqxmd.com/read/29078739/effects-of-a-new-combination-of-plant-extracts-plus-d-mannose-for-the-management-of-uncomplicated-recurrent-urinary-tract-infections
#18
RANDOMIZED CONTROLLED TRIAL
Carlo Genovese, Sergio Davinelli, Katia Mangano, Gianna Tempera, Daria Nicolosi, Salvatore Corsello, Franca Vergalito, Edoardo Tartaglia, Giovanni Scapagnini, Roberto Di Marco
Urinary tract infections (UTIs) are an economic burden for public health. The increasing prevalence of resistant bacteria which cause UTIs may be related to the inappropriate prescription of antibiotics. The aim of this preliminary study was to evaluate whether three different combinations of plant extracts plus d-mannose are effective in preventing the recurrence of UTIs. Three groups of patients received three combinations of plant extracts in conjunction with d-mannose. These were: berberine, arbutin and birch (group A); berberine, arbutin, birch and forskolin (group B); and proanthocyanidins (group C)...
April 2018: Journal of Chemotherapy
https://www.readbyqxmd.com/read/29065784/effect-of-vancomycin-initial-dosing-on-time-to-systemic-inflammatory-response-syndrome-resolution-in-patients-with-methicillin-resistant-staphylococcus-aureus-bacteremia
#19
Jessica Lynn Wesolek, Kelly McNorton, George Delgado, Christopher Alan Giuliano
Current guidelines suggest using vancomycin-loading doses for complicated infections despite a lack of evidence to support this practice. To address this gap, we performed a single-centre cohort study of 124 patients with sepsis due to methicillin-resistant Staphylococcus aureus bacteremia. Patients were allocated into two groups based on initial dose of vancomycin, <20 mg/kg or ≥20 mg/kg, and evaluated for time to resolution of systemic inflammatory response syndrome (SIRS). Among a cohort of 124 patients, 87 received vancomycin initial doses <20 mg/kg and 37 received ≥20 mg/kg...
April 2018: Journal of Chemotherapy
https://www.readbyqxmd.com/read/29063819/investigation-of-the-effects-of-various-antibiotics-against-klebsiella-pneumoniae-biofilms-on-in-vitro-catheter-model
#20
Emel Mataraci Kara, Berna Ozbek Celik
Klebsiella pneumoniae continues to be an important cause of community-acquired and nosocomial infection. This bacterium can cause catheter related infections by forming biofilm on the surface of catheter. The aim of our study is to determine the in vitro stability and efficacy of colistin, ciprofloxacin, tobramycin, doripenem and tigecycline alone, or in combination with clarithromycin or esomeprazole, as 24-h lock solutions against biofilm-embedded K. pneumoniae strains. The efficacy of antibiotic lock solutions was tested in an in vitro catheter biofilm model against K...
April 2018: Journal of Chemotherapy
journal
journal
30114
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"