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Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology

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https://www.readbyqxmd.com/read/29977075/sex-differences-in-neuroimmunity-as-an-inherent-risk-factor
#1
REVIEW
Margaret M McCarthy
Identifying and understanding the sources of inherent risk to neurodevelopmental disorders is a fundamental goal of neuroscience. Being male or being exposed to inflammation early in life are two known risk factors, but they are only infrequently associated with each other. Cellular and molecular mechanisms mediating the masculinization of the brain in animal models reveal a consistent role for inflammatory signaling molecules and immune cells in the healthy male brain. Why this is so remains in the realm of speculation but may have its origins in the maternal immune system...
June 29, 2018: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29959440/how-uncertainty-sensitizes-dopamine-neurons-and-invigorates-amphetamine-related-behaviors
#2
Mike J F Robinson, Patrick Anselme
No abstract text is available yet for this article.
June 29, 2018: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29977074/the-effects-of-ketamine-on-prefrontal-glutamate-neurotransmission-in-healthy-and-depressed-subjects
#3
Chadi G Abdallah, Henk M De Feyter, Lynnette A Averill, Lihong Jiang, Christopher L Averill, Golam M I Chowdhury, Prerana Purohit, Robin A de Graaf, Irina Esterlis, Christoph Juchem, Brian P Pittman, John H Krystal, Douglas L Rothman, Gerard Sanacora, Graeme F Mason
The ability of ketamine administration to activate prefrontal glutamate neurotransmission is thought to be a key mechanism contributing to its transient psychotomimetic effects and its delayed and sustained antidepressant effects. Rodent studies employing carbon-13 magnetic resonance spectroscopy (13 C MRS) methods have shown ketamine and other N-methyl-D-aspartate (NMDA) receptor antagonists to transiently increase measures reflecting glutamate-glutamine cycling and glutamate neurotransmission in the frontal cortex...
June 28, 2018: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/30008470/activity-dependent-neuroprotective-protein-adnp-is-an-alcohol-responsive-gene-and-negative-regulator-of-alcohol-consumption-in-female-mice
#4
Yarden Ziv, Nofar Rahamim, Noa Lezmy, Oren Even-Chen, Ohad Shaham, Anna Malishkevich, Eliezer Giladi, Ran Elkon, Illana Gozes, Segev Barak
Neuroadaptations in the brain reward system caused by excessive alcohol intake, lead to drinking escalation and alcohol use disorder phenotypes. Activity-dependent neuroprotective protein (ADNP) is crucial for brain development, and is implicated in neural plasticity in adulthood. Here, we discovered that alcohol exposure regulates Adnp expression in the mesolimbic system, and that Adnp keeps alcohol drinking in moderation, in a sex-dependent manner. Specifically, Sub-chronic alcohol treatment (2.5 g/kg/day for 7 days) increased Adnp mRNA levels in the dorsal hippocampus in both sexes, and in the nucleus accumbens of female mice, 24 h after the last alcohol injection...
June 27, 2018: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29977073/role-of-endocannabinoids-in-the-hippocampus-and-amygdala-in-emotional-memory-and-plasticity
#5
Amir Segev, Nachshon Korem, Tomer Mizrachi Zer-Aviv, Hila Abush, Rachel Lange, Garrett Sauber, Cecilia J Hillard, Irit Akirav
Posttraumatic stress disorder (PTSD) is characterized by the reexperiencing of a traumatic event and is associated with slower extinction of fear responses. Impaired extinction of fearful associations to trauma-related cues may interfere with treatment response, and extinction deficits may be premorbid risk factors for the development of PTSD. We examined the effects of exposure to a severe footshock followed by situational reminders (SRs) on extinction, plasticity, and endocannabinoid (eCB) content and activity in the hippocampal CA1 area and basolateral amygdala (BLA)...
June 27, 2018: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29946109/ronald-r-fieve
#6
David L Dunner
No abstract text is available yet for this article.
June 26, 2018: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29982266/genetic-loss-of-glun2b-in-d1-expressing-cell-types-enhances-long-term-cocaine-reward-and-potentiation-of-thalamo-accumbens-synapses
#7
Max E Joffe, Brandon D Turner, Eric Delpire, Brad A Grueter
Transient upregulation of GluN2B-containing NMDA receptors (R) in the nucleus accumbens (NAc) is proposed as an intermediate to long-term AMPAR plasticity associated with persistent cocaine-related behaviors. However, cell type- and input-specific contributions of GluN2B underlying lasting actions of cocaine remain to be elucidated. We utilized GluN2B cell type-specific knockouts and optogenetics to deconstruct the role of GluN2B in cocaine-induced NAc synaptic and behavioral plasticity. While reward learning was unaffected, loss of GluN2B in D1 dopamine receptor-expressing cells (D1) led to prolonged retention of reward memory...
June 25, 2018: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29973655/fear-extinction-disruption-in-a-developmental-rodent-model-of-schizophrenia-correlates-with-an-impairment-in-basolateral-amygdala-medial-prefrontal-cortex-plasticity
#8
Daniela L Uliana, Leonardo B M Resstel, Anthony A Grace
Schizophrenia patients typically exhibit prominent negative symptoms associated with deficits in extinction recall and decreased ventromedial prefrontal cortex activity (vmPFC, analogous to medial PFC infralimbic segment in rodents). mPFC activity modulates the activity of basolateral amygdala (BLA) and this connectivity is related to extinction. mPFC and BLA activity has been shown to be altered in the methylazoxymethanol acetate (MAM) developmental disruption model of schizophrenia. However, it is unknown if there are alterations in extinction processes in this model...
June 23, 2018: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29973654/neuronal-and-glial-factors-contributing-to-sex-differences-in-opioid-modulation-of-pain
#9
REVIEW
Dayna L Averitt, Lori N Eidson, Hillary H Doyle, Anne Z Murphy
Morphine remains one of the most widely prescribed opioids for alleviation of persistent and/or severe pain; however, multiple preclinical and clinical studies report that morphine is less efficacious in females compared to males. Morphine primarily binds to the mu opioid receptor, a prototypical G-protein coupled receptor densely localized in the midbrain periaqueductal gray. Anatomical and physiological studies conducted in the 1960s identified the periaqueductal gray, and its descending projections to the rostral ventromedial medulla and spinal cord, as an essential descending inhibitory circuit mediating opioid-based analgesia...
June 23, 2018: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29968846/sex-dependent-regulation-of-social-reward-by-oxytocin-an-inverted-u-hypothesis
#10
REVIEW
Johnathan M Borland, James K Rilling, Kyle J Frantz, H Elliott Albers
The rewarding properties of social interactions are essential for the expression of social behavior and the development of adaptive social relationships. Here, we review sex differences in social reward, and more specifically, how oxytocin (OT) acts in the mesolimbic dopamine system (MDS) to mediate the rewarding properties of social interactions in a sex-dependent manner. Evidence from rodents and humans suggests that same-sex social interactions may be more rewarding in females than in males. We propose that there is an inverted U relationship between OT dose, social reward, and neural activity within structures of the MDS in both males and females, and that this dose-response relationship is initiated at lower doses in females than males...
June 23, 2018: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29967368/targeting-the-affective-brain-a-randomized-controlled-trial-of-real-time-fmri-neurofeedback-in-patients-with-depression
#11
David M A Mehler, Moses O Sokunbi, Isabelle Habes, Kali Barawi, Leena Subramanian, Maxence Range, John Evans, Kerenza Hood, Michael Lührs, Paul Keedwell, Rainer Goebel, David E J Linden
Functional magnetic resonance imaging neurofeedback (fMRI-NF) training of areas involved in emotion processing can reduce depressive symptoms by over 40% on the Hamilton Depression Rating Scale (HDRS). However, it remains unclear if this efficacy is specific to feedback from emotion-regulating regions. We tested in a single-blind, randomized, controlled trial if upregulation of emotion areas (NFE) yields superior efficacy compared to upregulation of a control region activated by visual scenes (NFS). Forty-three moderately to severely depressed medicated patients were randomly assigned to five sessions augmentation treatment of either NFE or NFS training...
June 23, 2018: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29955151/pretreatment-and-early-treatment-cortical-thickness-is-associated-with-ssri-treatment-response-in-major-depressive-disorder
#12
Elizabeth A Bartlett, Christine DeLorenzo, Priya Sharma, Jie Yang, Mengru Zhang, Eva Petkova, Myrna Weissman, Patrick J McGrath, Maurizio Fava, R Todd Ogden, Benji T Kurian, Ashley Malchow, Crystal M Cooper, Joseph M Trombello, Melvin McInnis, Phillip Adams, Maria A Oquendo, Diego A Pizzagalli, Madhukar Trivedi, Ramin V Parsey
To date, there are no biomarkers for major depressive disorder (MDD) treatment response in clinical use. Such biomarkers could allow for individualized treatment selection, reducing time spent on ineffective treatments and the burden of MDD. In search of such a biomarker, multisite pretreatment and early-treatment (1 week into treatment) structural magnetic resonance (MR) images were acquired from 184 patients with MDD randomized to an 8-week trial of the selective serotonin reuptake inhibitor (SSRI) sertraline or placebo...
June 19, 2018: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29955150/inflaming-sex-differences-in-mood-disorders
#13
REVIEW
Jennifer R Rainville, Georgia E Hodes
Men and women often experience different symptoms or rates of occurrence for a variety of mood disorders. Many of the symptoms of mood disorders overlap with autoimmune disorders, which also have a higher prevalence in women. There is a growing interest in exploring the immune system to provide biomarkers for diagnosis of mood disorders, along with new targets for developing treatments. This review examines known sex differences in the immune system and their relationship to mood disorders. We focus on immune alterations associated with unipolar depression, bipolar depression, and anxiety disorders...
June 19, 2018: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29946108/sex-differences-in-neural-mechanisms-mediating-reward-and-addiction
#14
REVIEW
Jill B Becker, Elena Chartoff
There is increasing evidence in humans and laboratory animals for biologically based sex differences in every phase of drug addiction: acute reinforcing effects, transition from occasional to compulsive use, withdrawal-associated negative affective states, craving, and relapse. There is also evidence that many qualitative aspects of the addiction phases do not differ significantly between males and females, but one sex may be more likely to exhibit a trait than the other, resulting in population differences...
June 19, 2018: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29959439/diazepam-reverses-increased-anxiety-like-behavior-social-behavior-deficit-and-dopamine-dysregulation-following-withdrawal-from-acute-amphetamine
#15
Millie Rincón-Cortés, Kimberly G Gagnon, Hannah K Dollish, Anthony A Grace
Psychostimulants such as amphetamine (AMPH) increase dopamine (DA) release from ventral tegmental area (VTA) neurons, which is associated with their acute reinforcing actions. This positive state is followed by a negative affective state during the withdrawal period each time the drug is taken (i.e., opponent process theory). AMPH withdrawal is accompanied by symptoms of anxiety and depression, which are associated with DA system dysfunction in humans and animal models. Most studies have focused on the negative affective state after withdrawal from chronic drug administration; yet, this negative state appears even after a drug is taken for the first time in both humans and rodents...
June 18, 2018: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29946107/discrete-patterns-of-cortical-thickness-in-youth-with-bipolar-disorder-differentially-predict-treatment-response-to-quetiapine-but-not-lithium
#16
Wenjing Zhang, Yuan Xiao, Huaiqiang Sun, L Rodrigo Patino, Maxwell J Tallman, Wade A Weber, Caleb M Adler, Christina Klein, Jeffrey R Strawn, Fabiano G Nery, Qiyong Gong, John A Sweeney, Su Lui, Melissa P DelBello
The need for treatment response predictive biomarkers is being increasingly recognized in children and adolescents with psychiatric disorders. Structural gray matter abnormalities as a predictor of treatment outcome in pediatric bipolar disorder have not been systematically investigated, especially early in the illness course. With a prospective longitudinal study design, the present study enrolled 52 bipolar adolescents with no history of treatment with mood stabilizers or a therapeutic dose of antipsychotic drugs and 31 healthy controls...
June 18, 2018: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29946106/efficacy-tolerability-and-cognitive-effects-of-deep-transcranial-magnetic-stimulation-for-late-life-depression-a-prospective-randomized-controlled-trial
#17
Tyler S Kaster, Zafiris J Daskalakis, Yoshihiro Noda, Yuliya Knyahnytska, Jonathan Downar, Tarek K Rajji, Yechiel Levkovitz, Abraham Zangen, Meryl A Butters, Benoit H Mulsant, Daniel M Blumberger
Late-life depression (LLD) is a growing worldwide problem due to demographic changes, with limited treatment options due to high rates of pharmacotherapy adverse effects, accessibility of psychotherapy, and tolerability of electroconvulsive therapy. Novel neuromodulation techniques, such as repetitive transcranial magnetic stimulation (rTMS), may overcome these limitations. The objective of this study is to determine the efficacy, tolerability, and cognitive effects of high-dose deep rTMS in LLD. In this study we randomized older adults between 60 and 85 years old with major depressive disorder (MDD) to sham or active deep rTMS (H1 coil, 6012 pulses, 18 Hz, 120% of resting motor threshold) delivered over the dorsolateral and ventrolateral prefrontal cortex 5 days per week over 4 weeks...
June 18, 2018: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29967367/generation-of-silent-synapses-in-dentate-gyrus-correlates-with-development-of-alcohol-addiction
#18
Anna Beroun, Maria Nalberczak-Skóra, Zofia Harda, Małgorzata Piechota, Magdalena Ziółkowska, Anna Cały, Roberto Pagano, Kasia Radwanska
The brain circuits and synaptic processes that underlie alcohol addiction are currently the subject of intensive research. Here we focus on hippocampal circuitry and show that chemogenetic inhibition of dentate gyrus (DG) during presentation of alcohol-associated cues has long-lasting effects on mice behavior. DG inhibition enhances alcohol seeking and drinking, suggesting that DG regulates addiction-related behaviors. To test this hypothesis, we perform whole-cell patch-clamp recordings from the granule cells of DG and look for electrophysiological correlates of alcohol addiction...
June 15, 2018: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29950584/cross-species-evidence-from-human-and-rat-brain-transcriptome-for-growth-factor-signaling-pathway-dysregulation-in-major-depression
#19
Lucia Carboni, Luca Marchetti, Mario Lauria, Peter Gass, Barbara Vollmayr, Amanda Redfern, Lesley Jones, Maria Razzoli, Karim Malki, Veronica Begni, Marco A Riva, Enrico Domenici, Laura Caberlotto, Aleksander A Mathé
An enhanced understanding of the pathophysiology of depression would facilitate the discovery of new efficacious medications. To this end, we examined hippocampal transcriptional changes in rat models of disease and in humans to identify common disease signatures by using a new algorithm for signature-based clustering of expression profiles. The tool identified a transcriptomic signature comprising 70 probesets able to discriminate depression models from controls in both Flinders Sensitive Line and Learned Helplessness animals...
June 12, 2018: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29930387/response-to-letter-to-editor-precision-medicine-in-alcohol-dependence-evidence-of-efficacy-and-initial-support-for-comparative-effectiveness
#20
LETTER
Karl Mann, Corey R Roos, Katie Witkiewitz
No abstract text is available yet for this article.
June 12, 2018: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
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