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Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology

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https://www.readbyqxmd.com/read/30410014/intrinsic-functional-connectivity-correlates-of-person-level-risk-for-bipolar-disorder-in-offspring-of-affected-parents
#1
Danella M Hafeman, Henry W Chase, Kelly Monk, Lisa Bonar, Mary Beth Hickey, Alicia McCaffrey, Simona Graur, Anna Manelis, Cecile D Ladouceur, John Merranko, David A Axelson, Benjamin I Goldstein, Tina R Goldstein, Boris Birmaher, Mary L Phillips
Offspring of parents with bipolar disorder (OBP) are at increased risk to develop bipolar disorder (BD). Alterations in resting-state functional connectivity (rsFC) have been identified in OBP; however, replication has been limited and correlation with person-level risk is unknown. A recent study found reduced rsFC between left inferior frontal gyrus (IFG) and clusters in the left insula (LINS), lentiform nucleus (LENT), and midcingulate cortex (MCING) in OBP (Roberts et al. 2017); here, we aim to extend these findings to at-risk youth...
November 8, 2018: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/30401942/correction-chronic-clozapine-treatment-restrains-via-hdac2-the-performance-of-mglu2-receptor-agonism-in-a-rodent-model-of-antipsychotic-activity
#2
Mario de la Fuente Revenga, Daisuke Ibi, Travis Cuddy, Rudy Toneatti, Mitsumasa Kurita, Maryum K Ijaz, Michael F Miles, Jennifer T Wolstenholme, Javier González-Maeso
Following the publication of this article Figs. 3b, c were published incorrectly. Also in sub-panel c of Fig. 4, 'Chronic cloza ine' should read 'Chronic clozapine'.
November 6, 2018: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/30391995/moderators-for-depressed-mood-and-systemic-and-transcriptional-inflammatory-responses-a-randomized-controlled-trial-of-endotoxin
#3
Michael R Irwin, Steve Cole, Richard Olmstead, Elizabeth C Breen, Hyong Jin Cho, Mona Moieni, Naomi I Eisenberger
Activation of the innate immune system is thought to contribute to depression. Multiple social and behavioral factors are also known to instigate depression. Whether these socio-behavioral factors interact with inflammatory stimuli to alter proinflammatory responses and depressed mood is not known. In 115 healthy adults, social, emotional, and behavioral factors were assessed at baseline. A single infusion of endotoxin (Escherichia coli; 0.8 ng/kg of body weight) or placebo (0.9% saline) was administered with hourly assessment of depressed mood and proinflammatory cytokines (interleukin-6 (IL-6); tumor necrosis factor-α (TNF))...
November 3, 2018: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/30390066/laser-capture-microdissection-targeted-mass-spectrometry-a-method-for-multiplexed-protein-quantification-within-individual-layers-of-the-cerebral-cortex
#4
Matthew L MacDonald, Daley Favo, Megan Garver, Zhe Sun, Dominique Arion, Ying Ding, Nathan Yates, Robert A Sweet, David A Lewis
The mammalian neocortex is organized into layers distinguished by the size, packing density, and connectivity of their constituent neurons. Many neuropsychiatric illnesses are complex trait disorders with etiologic factors converging on neuronal protein networks. Cortical pathology of neuropsychiatric diseases, such as schizophrenia, is often restricted to, or more pronounced in, certain cortical layers, suggesting that genetic vulnerabilities manifest with laminar specificity. Thus, the ability to investigate cortical layer-specific protein levels in human postmortem brain is highly desirable...
November 2, 2018: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/30390065/neural-modulation-of-social-reinforcement-learning-by-intranasal-oxytocin-in-male-adults-with-high-functioning-autism-spectrum-disorder-a-randomized-trial
#5
Jana A Kruppa, Anna Gossen, Eileen Oberwelland Weiß, Gregor Kohls, Nicola Großheinrich, Hannah Cholemkery, Christine M Freitag, Wolfram Karges, Elke Wölfle, Judith Sinzig, Gereon R Fink, Beate Herpertz-Dahlmann, Kerstin Konrad, Martin Schulte-Rüther
Reduced social motivation is a hallmark of individuals with autism spectrum disorders (ASDs). Although the exact neural mechanisms are unclear, oxytocin has been shown to enhance motivation and attention to social stimuli, suggesting a potential to augment social reinforcement learning as the central mechanism of behavioral interventions in ASD. We tested how reinforcement learning in social contexts and associated reward prediction error (RPE) signals in the nucleus accumbens (NAcc) were modulated by intranasal oxytocin...
November 2, 2018: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/30390064/endocannabinoid-control-of-the-insular-bed-nucleus-of-the-stria-terminalis-circuit-regulates-negative-affective-behavior-associated-with-alcohol-abstinence
#6
Samuel W Centanni, Bridget D Morris, Joseph R Luchsinger, Gaurav Bedse, Tracy L Fetterly, Sachin Patel, Danny G Winder
Negative affect is a core symptom domain associated with an array of neurological and psychiatric disorders and is only partially targeted by current therapies, highlighting the need for better, more targeted treatment options. This study focuses on negative affective symptoms associated with prolonged alcohol abstinence, one of the leading causes of relapse. Using a mouse model of chronic alcohol consumption followed by forced abstinence (CDFA), prolonged alcohol abstinence increased c-fos expression and spontaneous glutamatergic neurotransmission in the dorsal bed nucleus of the stria terminalis (dBNST), a region heavily implicated in negative affect in both humans and rodents...
November 2, 2018: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/30377381/neurophysiologic-measures-of-target-engagement-predict-response-to-auditory-based-cognitive-training-in-treatment-refractory-schizophrenia
#7
William C Hochberger, Yash B Joshi, Michael L Thomas, Wendy Zhang, Andrew W Bismark, Emily B H Treichler, Melissa Tarasenko, John Nungaray, Joyce Sprock, Lauren Cardoso, Neal Swerdlow, Gregory A Light
Cognitive impairment is a core feature of schizophrenia and a strong predictor of psychosocial disability. Auditory-based targeted cognitive training (TCT) aims to enhance verbal learning and other domains of cognitive functioning through "bottom-up" tuning of the neural systems underlying early auditory information processing (EAIP). Although TCT has demonstrated efficacy at the group level, individual response to TCT varies considerably, with nearly half of patients showing little-to-no benefit...
October 30, 2018: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/30377380/manipulation-of-dorsal-raphe-serotonergic-neurons-modulates-active-coping-to-inescapable-stress-and-anxiety-related-behaviors-in-mice-and-rats
#8
Naoya Nishitani, Kazuki Nagayasu, Nozomi Asaoka, Mayumi Yamashiro, Chihiro Andoh, Yuma Nagai, Haruko Kinoshita, Hiroyuki Kawai, Norihiro Shibui, Beihui Liu, James Hewinson, Hisashi Shirakawa, Takayuki Nakagawa, Hitoshi Hashimoto, Sergey Kasparov, Shuji Kaneko
Major depression and anxiety disorders are a social and economic burden worldwide. Serotonergic signaling has been implicated in the pathophysiology of these disorders and thus has been a crucial target for pharmacotherapy. However, the precise mechanisms underlying these disorders are still unclear. Here, we used species-optimized lentiviral vectors that were capable of efficient and specific transduction of serotonergic neurons in mice and rats for elucidation of serotonergic roles in anxiety-like behaviors and active coping behavior in both species...
October 30, 2018: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/30375509/in-memoriam
#9
Robert T Rubin
No abstract text is available yet for this article.
October 30, 2018: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/30375498/prefrontal-cortex-response-to-drug-cues-craving-and-current-depressive-symptoms-are-associated-with-treatment-outcomes-in-methadone-maintained-patients
#10
Andrew S Huhn, Mary M Sweeney, K Brooner, Michael S Kidorf, D Andrew Tompkins, Hasan Ayaz, Kelly E Dunn
Methadone maintenance is an effective treatment for opioid use disorder, yet many methadone-maintained patients (MMPs) continue to struggle with chronic relapse. The current study evaluated whether functional near-infrared spectroscopy (fNIRS) could identify prefrontal cortex (PFC) markers of ongoing opioid use in MMPs, and whether clinical measures of depression and self-report measures of craving would also be associated with opioid use. MMPs (n = 29) underwent a drug cue reactivity paradigm during fNIRS measurements of PFC reactivity...
October 30, 2018: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/30405186/intermittent-intake-of-rapid-cocaine-injections-promotes-the-risk-of-relapse-and-increases-mesocorticolimbic-bdnf-levels-during-abstinence
#11
Aliou B Gueye, Florence Allain, Anne-Noël Samaha
Cocaine is thought to be more addictive when it reaches the brain rapidly. We predicted that variation in the speed of cocaine delivery influences the likelihood of addiction in part by determining the risk of relapse after abstinence. Under an intermittent-access schedule, rats pressed a lever for rapid (injected over 5 s) or slower (90 s) intravenous cocaine injections (0.5 mg/kg/injection). Control rats self-administered food pellets. A tone-light cue accompanied each self-administered reward. The 5s- and 90s-rats took a similar average amount of cocaine...
October 26, 2018: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/30367144/in-memoriam-arvid-carlsson-pioneering-researcher-and-nobel-laureate
#12
Birte Glenthøj, H Christian Fibiger
No abstract text is available yet for this article.
October 26, 2018: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/30375508/effects-of-bdnf-val-66-met-genotype-and-schizophrenia-familial-risk-on-a-neural-functional-network-for-cognitive-control-in-humans
#13
J I Schweiger, E Bilek, A Schäfer, U Braun, C Moessnang, A Harneit, P Post, K Otto, N Romanczuk-Seiferth, S Erk, C Wackerhagen, M Mattheisen, T W Mühleisen, S Cichon, M M Nöthen, J Frank, S H Witt, M Rietschel, A Heinz, H Walter, A Meyer-Lindenberg, H Tost
Cognitive control represents an essential neuropsychological characteristic that allows for the rapid adaption of a changing environment by constant re-allocation of cognitive resources. This finely tuned mechanism is impaired in psychiatric disorders such as schizophrenia and contributes to cognitive deficits. Neuroimaging has highlighted the contribution of the anterior cingulate cortex (ACC) and prefrontal regions (PFC) on cognitive control and demonstrated the impact of genetic variation, as well as genetic liability for schizophrenia...
October 25, 2018: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/30356095/dopamine-is-a-double-edged-sword-dopaminergic-modulation-enhances-memory-retrieval-performance-but-impairs-metacognition
#14
Mareike Clos, Nico Bunzeck, Tobias Sommer
While memory encoding and consolidation processes have been linked with dopaminergic signaling for a long time, the role of dopamine in episodic memory retrieval remained mostly unexplored. Based on previous observations of striatal activity during memory retrieval, we used pharmacological functional magnetic resonance imaging to investigate the effects of dopamine on retrieval performance and metacognitive memory confidence in healthy humans. Dopaminergic modulation by the D2 antagonist haloperidol administered acutely during the retrieval phase improved recognition accuracy of previously learned pictures significantly and was associated with increased activity in the substantia nigra/ventral tegmental area, locus coeruleus, hippocampus, and amygdala during retrieval...
October 25, 2018: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/30356094/identifying-substance-use-risk-based-on-deep-neural-networks-and-instagram-social-media-data
#15
Saeed Hassanpour, Naofumi Tomita, Timothy DeLise, Benjamin Crosier, Lisa A Marsch
Social media may provide new insight into our understanding of substance use and addiction. In this study, we developed a deep-learning method to automatically classify individuals' risk for alcohol, tobacco, and drug use based on the content from their Instagram profiles. In total, 2287 active Instagram users participated in the study. Deep convolutional neural networks for images and long short-term memory (LSTM) for text were used to extract predictive features from these data for risk assessment. The evaluation of our approach on a held-out test set of 228 individuals showed that among the substances we evaluated, our method could estimate the risk of alcohol abuse with statistical significance...
October 24, 2018: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/30341410/decoding-the-role-of-the-microbiome-on-amygdala-function-and-social-behaviour
#16
John F Cryan, Timothy G Dinan
No abstract text is available yet for this article.
October 19, 2018: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/30341409/david-m-jacobowitz
#17
Harvey B Pollard, Lois Winsky
No abstract text is available yet for this article.
October 19, 2018: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/30327498/resting-state-functional-connectivity-cortical-gaba-and-neuroactive-steroids-in-peripartum-and-peripartum-depressed-women-a-functional-magnetic-imaging-and-resonance-study
#18
Kristina M Deligiannidis, Christina L Fales, Aimee R Kroll-Desrosiers, Scott A Shaffer, Vanessa Villamarin, Yanglan Tan, Janet E Hall, Blaise B Frederick, Elif M Sikoglu, Richard A Edden, Anthony J Rothschild, Constance M Moore
Postpartum depression (PPD) is associated with abnormalities in resting-state functional connectivity (RSFC) but the underlying neurochemistry is unclear. We hypothesized that peripartum GABAergic neuroactive steroids (NAS) are related to cortical GABA concentrations and RSFC in PPD as compared to healthy comparison women (HCW). To test this, we measured RSFC with fMRI and GABA+/Creatine (Cr) concentrations with proton magnetic resonance spectroscopy (1 H MRS) in the pregenual anterior cingulate (pgACC) and occipital cortices (OCC) and quantified peripartum plasma NAS...
October 17, 2018: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/30323359/low-dose-intranasal-oxytocin-delivered-with-breath-powered-device-modulates-pupil-diameter-and-amygdala-activity-a-randomized-controlled-pupillometry-and-fmri-study
#19
Daniel S Quintana, Lars T Westlye, Dag Alnæs, Tobias Kaufmann, Ramy A Mahmoud, Knut T Smerud, Per G Djupesland, Ole A Andreassen
Little is known about how intranasally administered oxytocin reaches the brain and modulates social behavior and cognition. Pupil dilation is a sensitive index of attentional allocation and effort, and inter-individual variability in pupil diameter during performance of social-cognitive tasks may provide a better assessment of pharmacological effects on the brain than behavioral measures. Here, we leverage the close relationship between pupil and neural activity to inform our understanding of nose-to-brain oxytocin routes and possible dose-response relationships...
October 16, 2018: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/30310121/gsk3%C3%AE-in-the-prefrontal-cortex-a-molecular-handle-specific-to-addiction-pathology
#20
Andrew L Eagle, A J Robison
No abstract text is available yet for this article.
October 11, 2018: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
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