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Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology

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https://www.readbyqxmd.com/read/30232407/tinkering-with-thc-to-cbd-ratios-in-marijuana
#1
Bertha K Madras
No abstract text is available yet for this article.
September 19, 2018: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/30228373/dynamic-network-targeting-for-closed-loop-deep-brain-stimulation
#2
Alexander B Herman, Alik S Widge
No abstract text is available yet for this article.
September 18, 2018: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/30214060/motion-mapping-in-humans-as-a-biomarker-for-psychiatric-disorders
#3
Ipsit V Vahia, Brent P Forester
No abstract text is available yet for this article.
September 13, 2018: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/30214059/nmda-receptor-independent-actions-of-ketamine-a-new-chapter-in-a-story-that-s-not-so-old
#4
Nathan H Wray, Mark M Rasenick
No abstract text is available yet for this article.
September 13, 2018: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/30209408/tak-137-an-ampa-r-potentiator-with-little-agonistic-effect-has-a-wide-therapeutic-window
#5
Akiyoshi Kunugi, Maiko Tanaka, Atsushi Suzuki, Yasukazu Tajima, Noriko Suzuki, Motohisa Suzuki, Shinji Nakamura, Haruhiko Kuno, Akihiro Yokota, Satoshi Sogabe, Yohei Kosugi, Yasuyuki Awasaki, Tomohiro Kaku, Haruhide Kimura
Activation of α-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid receptor (AMPA-R) is a promising strategy to treat psychiatric and neurological diseases if issues of bell-shaped response and narrow safety margin against seizure can be overcome. Here, we show that structural interference at Ser743 in AMPA-R is a key to lower the agonistic effect of AMPA-R potentiators containing dihydropyridothiadiazine 2,2-dioxides skeleton. With this structural insight, TAK-137, 9-(4-phenoxyphenyl)-3,4-dihydropyrido[2,1-c][1,2,4]thiadiazine 2,2-dioxide, was discovered as a novel AMPA-R potentiator with a lower agonistic effect than an AMPA-R potentiator LY451646 ((R)-N-(2-(4'-cyanobiphenyl-4-yl)propyl)propane-2-sulfonamide) in rat primary neurons...
September 12, 2018: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/30209407/increased-risk-of-diseases-of-the-basal-ganglia-and-cerebellum-in-patients-with-a-history-of-attention-deficit-hyperactivity-disorder
#6
Karen Curtin, Annette E Fleckenstein, Brooks R Keeshin, Deborah A Yurgelun-Todd, Perry F Renshaw, Ken R Smith, Glen R Hanson
Attention-deficit/hyperactivity disorder (ADHD) is marked by an ongoing pattern of inattention and/or hyperactivity and involves dysregulated dopaminergic pathways. Dopaminergic agents (i.e., amphetamine and methylphenidate) are thus prescribed to treat ADHD. As little is known regarding long-term consequences of either ADHD or its treatment, the objective of this study was to determine if either alters the risk of diseases of the basal ganglia and cerebellum, including Parkinson's disease. Statewide medical records from 1996 to 2016 were retrieved from the Utah Population Database to conduct a retrospective cohort study...
September 12, 2018: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/30206420/amyloid-oligomer-interactions-and-polymorphisms-disease-relevant-distinct-assembly-of-%C3%AE-synuclein-and-tau
#7
Urmi Sengupta, Rakez Kayed
No abstract text is available yet for this article.
September 11, 2018: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/30206419/novel-models-of-drug-relapse-and-craving-after-voluntary-abstinence
#8
Marco Venniro, Daniele Caprioli, Yavin Shaham
No abstract text is available yet for this article.
September 11, 2018: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/30202048/antidepressant-potential-of-metabotropic-glutamate-receptor-mglu-2-and-mglu-3-negative-allosteric-modulators
#9
Max E Joffe, P Jeffrey Conn
No abstract text is available yet for this article.
September 10, 2018: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/30202047/positive-allosteric-modulation-of-the-5-ht-2c-receptor-implications-for-neuropsychopharmacology-and-neurotherapeutics
#10
Jia Zhou, Kathryn A Cunningham
No abstract text is available yet for this article.
September 10, 2018: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/30214058/sex-differences-in-hippocampal-cognition-and-neurogenesis
#11
REVIEW
Shunya Yagi, Liisa A M Galea
Sex differences are reported in hippocampal plasticity, cognition, and in a number of disorders that target the integrity of the hippocampus. For example, meta-analyses reveal that males outperform females on hippocampus-dependent tasks in rodents and in humans, furthermore women are more likely to experience greater cognitive decline in Alzheimer's disease and depression, both diseases characterized by hippocampal dysfunction. The hippocampus is a highly plastic structure, important for processing higher order information and is sensitive to the environmental factors such as stress...
September 7, 2018: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/30194423/are-lithium-effects-dependent-on-genetic-epigenetic-architecture
#12
Consuelo Walss-Bass, Gabriel R Fries
No abstract text is available yet for this article.
September 7, 2018: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/30194422/the-ventromedial-prefrontal-cortex-a-putative-locus-for-trait-inattention
#13
Matthew D Albaugh, Alexandra S Potter
No abstract text is available yet for this article.
September 7, 2018: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/30188517/glycogen-synthase-kinase-3-beta-regulates-ethanol-consumption-and-is-a-risk-factor-for-alcohol-dependence
#14
Andrew van der Vaart, Xianfang Meng, M Scott Bowers, Angela M Batman, Fazil Aliev, Sean P Farris, Jennifer S Hill, Thomas A Green, Danielle Dick, Jennifer T Wolstenholme, Michael F Miles
Understanding how ethanol actions on brain signal transduction and gene expression lead to excessive consumption and addiction could identify new treatments for alcohol dependence. We previously identified glycogen synthase kinase 3-beta (Gsk3b) as a member of a highly ethanol-responsive gene network in mouse medial prefrontal cortex (mPFC). Gsk3b has been implicated in dendritic function, synaptic plasticity and behavioral responses to other drugs of abuse. Here, we investigate Gsk3b in rodent models of ethanol consumption and as a risk factor for human alcohol dependence...
September 6, 2018: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/30188516/effects-of-long-term-high-fat-food-or-methamphetamine-intake-and-serotonin-2c-receptors-on-reversal-learning-in-female-rhesus-macaques
#15
Maylen Perez Diaz, Mark E Wilson, Leonard L Howell
Perseverative behavior has been highly implicated in addiction. Activation of serotonin 2C receptors (5-HT2C Rs) attenuates cocaine and high caloric food intake, but whether a 5-HT2C R agonist can reduce high caloric diet (HCD) or methamphetamine (METH) intake and response perseveration remains unknown. Clarifying the role of 5-HT2C Rs in these behaviors will improve knowledge of neurochemical processes that regulate flexible decision-making and whether improvements in decision-making are accompanied by decreases in HCD or METH intake...
September 6, 2018: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/30188515/pet-imaging-reveals-lower-kappa-opioid-receptor-availability-in-alcoholics-but-no-effect-of-age
#16
Aishwarya Vijay, Dana Cavallo, Alissa Goldberg, Bart de Laat, Nabeel Nabulsi, Yiyun Huang, Suchitra Krishnan-Sarin, Evan D Morris
Opioid receptors are implicated in alcoholism, other addictions, withdrawal, and depression, and are considered potential pharmacological targets for treatment. Our goal in the present study was to compare the availability of kappa opioid receptors (KOR) between an alcohol-dependent cohort (AD) and a healthy control cohort (HC). Sixty-four participants-36 AD and 28 HC-underwent PET scans with [11 C]LY2795050, a selective kappa antagonist tracer. Partial-volume correction was applied to all PET data to correct for atrophy...
September 6, 2018: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/30188514/food-addiction-a-valid-concept
#17
REVIEW
Paul C Fletcher, Paul J Kenny
Can food be addictive? What does it mean to be a food addict? Do common underlying neurobiological mechanisms contribute to drug and food addiction? These vexing questions have been the subject of considerable interest and debate in recent years, driven in large part by the major health concerns associated with dramatically increasing body weights and rates of obesity in the United States, Europe, and other regions with developed economies. No clear consensus has yet emerged on the validity of the concept of food addiction and whether some individuals who struggle to control their food intake can be considered food addicts...
September 6, 2018: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/30188513/early-life-stress-leads-to-sex-differences-in-development-of-depressive-like-outcomes-in-a-mouse-model
#18
Haley L Goodwill, Gabriela Manzano-Nieves, Meghan Gallo, Hye-In Lee, Esther Oyerinde, Thomas Serre, Kevin G Bath
Childhood trauma and neglect influence emotional development and increase the risk for and severity of mental illness. Women have a heightened susceptibility to the effects of early life stress (ELS) and are twice as likely as men to develop debilitating, stress-associated disorders later in life, such as major depressive disorder (MDD). Until now, mouse models of depression have been largely unsuccessful at replicating the diverse symptomatology of this disease and the sex bias in vulnerability. From P4 to P11, a limited bedding model that leads to fragmented maternal care, was used to induce ELS...
September 6, 2018: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/30188512/effects-of-sedative-drug-use-on-the-dopamine-system-a-systematic-review-and-meta-analysis-of-in-vivo-neuroimaging-studies
#19
REVIEW
Felicia Kamp, Lisa Proebstl, Nora Penzel, Kristina Adorjan, Andrej Ilankovic, Oliver Pogarell, Gabi Koller, Michael Soyka, Peter Falkai, Nikolaos Koutsouleris, Joseph Kambeitz
Use of alcohol, cannabis and opioids is highly prevalent and is associated with global disease burden and high economic costs. The exact pathophysiology of abuse or addiction associated with these sedative substances is not completely understood, but previous research implicates the important role of the striatal dopamine system in the addiction process. Multiple studies investigated changes in the striatal dopamine systems of users of sedative substances, but currently these results are very heterogeneous...
August 27, 2018: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/30188511/interactive-effects-between-hemizygous-15q13-3-microdeletion-and-peripubertal-stress-on-adult-behavioral-functions
#20
Sandra Giovanoli, Thomas M Werge, Preben B Mortensen, Michael Didriksen, Urs Meyer
15q13.3 microdeletion is one of several gene copy number variants (CNVs) conferring increased risk of psychiatric and neurological disorders. This microdeletion gives rise to a variable spectrum of pathological phenotypes, ranging from asymptomatic to severe clinical outcomes. The reasons for these varying phenotypic outcomes remain unknown. Using a mouse model of hemizygous deletion of the orthologous region of 15q13.3, the present study examined whether exposure to stressful life events might interact with hemizygous 15q13...
August 27, 2018: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
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