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Journal of Internal Medicine

E Shantsila, A Ghattas, H R Griffiths, G Y H Lip
AIMS: There are limited data on the role of human monocyte subsets in ST-elevation myocardial infarction (STEMI). The study aimed to establish the relationship between monocyte subsets, their phagocytic and nuclear factor κB (NFκB) activity and outcomes in STEMI. METHODS: Monocyte subsets and their phagocytic activity and intracellular levels of inhibitory κB kinase β (IKKβ, marker of NFκB activity) were measured by flow cytometry in 245 patients with STEMI, median follow-up of 46 months...
January 15, 2019: Journal of Internal Medicine
A Calderón-Larrañaga, L Fratiglioni
No abstract text is available yet for this article.
January 9, 2019: Journal of Internal Medicine
A J Lamparello, R A Namas, G Constantine, T O McKinley, E Elster, Y Vodovotz, T R Billiar
Progress in the testing of therapies targeting the immune response following trauma, a leading cause of morbidity and mortality worldwide, has been slow. We propose that the design of interventional trials in trauma would benefit from a scheme or platform that could support the identification and implementation of prognostic strategies for patient stratification. Here, we propose a stratification scheme based on defined time periods or windows following the traumatic event. This 'time-window' model allows for the incorporation of prognostic variables ranging from circulating biomarkers and clinical data to patient-specific information such as gene variants to predict adverse short- or long-term outcomes...
January 9, 2019: Journal of Internal Medicine
M Nahrendorf
Myeloid cells assume a wide range of phenotypes, some of which are protective against injury and infection whilst others promote cardiovascular disease. This heterogeneity is partially caused by switching of cell sources from local tissue-resident macrophage proliferation to recruitment of circulating cells, and partially due to macrophages' phenotypic plasticity. While long-lived tissue-resident macrophages support development, tissue homoeostasis and cardiac conduction, monocyte-derived cells may promote destruction of the arterial wall and the myocardium, leading to organ ischaemia and heart failure...
December 25, 2018: Journal of Internal Medicine
Charles Feldman, Staffan Normark, Birgitta Henriques Normark, Ronald Anderson
It is now well recognized that cardiovascular events (CVE) occur quite commonly, both in the acute phase and in the long-term, in patients with community-acquired pneumonia (CAP). CVE have been noted in up to 30% of patients hospitalized with all-cause CAP. One systematic review and meta-analysis of hospitalized patients with all-cause CAP, noted that the incidence rates for overall cardiac events were 17.7%, for incident heart failure were 14.1%, for acute coronary syndromes were 5.3% and for incident cardiac arrhythmias were 4...
December 25, 2018: Journal of Internal Medicine
O M P Jolobe
No abstract text is available yet for this article.
December 21, 2018: Journal of Internal Medicine
N Javaud, O Fain
No abstract text is available yet for this article.
December 21, 2018: Journal of Internal Medicine
Charles N Serhan, Xavier de la Rosa, Charlotte Jouvene
Excessive chronic inflammation is linked to many diseases and considered a stress factor in humans [1-4]. Today the resolution of inflammation is widely recognized as a cellular biochemically active process involving biosynthesis of a novel superfamily of endogenous chemical signals coined specialized pro-resolving mediators (SPM) [5]. Herein, we review recent evidence indicating a role for the vagus nerve and vagotomy in the regulation of lipid mediators. Vagotomy reduces pro-resolving mediators including the lipoxins, resolvins, protectins and maresins delaying resolution in mouse peritonitis...
December 19, 2018: Journal of Internal Medicine
Frédéric Baron, Myriam Labopin, Annalisa Ruggeri, Fernanda Volt, Mohamad Mohty, Didier Blaise, Patrice Chevallier, Jaime Sanz, Nathalie Fegueux, Jan J Cornelissen, Alessandro Rambaldi, Bipin Savani, Eliane Gluckman, Arnon Nagler
BACKGROUND: We conducted a retrospective survey within the European Society for Blood and Marrow Transplantation (EBMT) registry to assess the outcomes of cord blood transplantation (CBT) in secondary acute myeloid leukemia (sAML). METHODS: Inclusion criteria consisted of ≥ 18 years of age, sAML, first CBT between 2002 and 2016, and either first complete remission (CR) or active disease at CBT. RESULTS: One hundred forty six patients met the study inclusion criteria...
December 18, 2018: Journal of Internal Medicine
J Fest, R Ruiter, S P Mooijaart, M A Ikram, C H J van Eijck, B H Stricker
BACKGROUND: A very high erythrocyte sedimentation rate (ESR) is usually an indication of underlying pathology. Additionally, a moderately elevated ESR may also be attributable to biological ageing. Whether the ESR is a prognostic factor for mortality, regardless of age, has been scarcely investigated. Therefore, the objective was to analyse the association between elevated ESR levels and the risk of mortality in a prospective cohort of the general population. METHODS: We studied data from the Rotterdam Study (1990-2014)...
December 9, 2018: Journal of Internal Medicine
A Muth, J Crona, O Gimm, A Elmgren, K Filipsson, M Stenmark Askmalm, J Sandstedt, M Tengvar, E Tham
Pheochromocytomas (PCC) and paragangliomas (PGL), collectively abbreviated PPGL are rare tumours originating from the chromaffin cells in the adrenal medulla (PCC) or the sympathetic or parasympathetic extra-adrenal paraganglia (PGL) (1, 2), Figure 1. The enlarged cell volume leads to increased levels of catecholamines (adrenaline, noraderenaline and/or dopamine) and their metabolites which can be measured in plasma or urine for biochemical diagnosis. Hormone-producing PPGL commonly originate from sympathetic paraganglia in the adrenal glands, abdomen or pelvis (3)...
December 8, 2018: Journal of Internal Medicine
Wei Shen Tan, Amar Ahmad, Andrew Feber, Hugh Mostafid, Jo Cresswell, Christian D Fankhauser, Sharon Waisbrod, Thomas Hermanns, Peter Sasieni, John D Kelly
BACKGROUND: A lack of consensus exists among national guidelines regarding who should be investigated for haematuria. Type of haematuria and age specific thresholds are frequently used to guide referral for investigation of haematuria. OBJECTIVES: To develop and externally validate the haematuria cancer risk score (HCRS) to improve patient selection for investigation of haematuria. METHODS: Development cohort comprise of 3,539 prospectively recruited patients recruited at 40 UK hospitals (DETECT 1; ClinicalTrials...
December 6, 2018: Journal of Internal Medicine
A Matikas, T Foukakis, J Bergh
No abstract text is available yet for this article.
November 29, 2018: Journal of Internal Medicine
Eva Rye Rasmussen, Anton Pottegård, Anette Bygum, Christian von Buchwald, Preben Homøe, Jesper Hallas
BACKGROUND: It has long been suggested that angiotensin-converting enzyme inhibitors (ACEi) and angiotensin II receptor blockers (AT2s) have some degree of 'cross-reactivity' in causing angioedema. Therefore, caution has been advised when switching patients with ACEi-related angioedema to an AT2. OBJECTIVES: To clarify whether AT2s can be used safely in patients with a history of angioedema during ACEi treatment and to estimate the incidence rate of angioedema in patients subsequently treated with other antihypertensive drugs (beta-adrenergic blockers, calcium channel blockers, thiazides and analogues) or no antihypertensives...
November 28, 2018: Journal of Internal Medicine
Marianne C Astor, Wendy Zhu, Sigridur Björnsdottir, Jens Bollerslev, Olle Kämpe, Eystein S Husebye
BACKGROUND: Patients with hypoparathyroidism are at risk of both hypocalcemic and hypercalcemic crisis. Patients report that health professionals do not always respond adequately in an acute situation. The extent and handling of severe hypo- and hypercalcemia in hypoparathyroidism is unknown. AIMS: To outline the need for a medical emergency card for primary hypoparathyroidism. METHOD: Postal survey among Norwegian and Swedish patients with chronic hypoparathyroidism of all causes...
November 28, 2018: Journal of Internal Medicine
Henrik Zetterberg, Bengt Winblad, Charles Bernick, Kristine Yaffe, Marek Majdan, Gunilla Johansson, Virginia Newcombe, Lars Nyberg, David Sharp, Olli Tenovuo, Kaj Blennow
Traumatic brain injury (TBI) is clinically divided into a spectrum of severities, with mild TBI being the least severe form and a frequent occurrence in contact sports, such as ice hockey, American football, rugby, horse riding and boxing. Mild TBI is caused by blunt non-penetrating head trauma that causes movement of the brain and stretching and tearing of axons, with diffuse axonal injury being a central pathogenic mechanism. Mild TBI is in principle synonymous with concussion; both have similar criteria in which the most important elements are acute alteration or loss of consciousness and/or post-traumatic amnesia following head trauma and no apparent brain changes on standard neuroimaging...
November 27, 2018: Journal of Internal Medicine
S A Mohamed
No abstract text is available yet for this article.
November 26, 2018: Journal of Internal Medicine
T Willinger
Cholesterol is an essential molecule for life. It is a component of the cell membrane, and it is a precursor molecule for bile acids, vitamin D and steroid hormones. Cholesterol is actively metabolized, but the impact of endogenous cholesterol metabolites on immune function, especially in the intestine, is poorly understood. In this review, I focus on oxysterols, hydroxylated forms of cholesterol, and their specialized functions in intestinal immunity. Oxysterols act through various intracellular and extracellular receptors and serve as key metabolic signals, coordinating immune activity and inflammation...
November 26, 2018: Journal of Internal Medicine
K M Eggers, M Hjort, T Baron, T Jernberg, A M Nordenskjöld, P Tornvall, B Lindahl
BACKGROUND: Myocardial infarction (MI) with nonobstructive coronary arteries (MINOCA) is receiving increasing interest as a prognostically adverse entity distinct from myocardial infarction with significant coronary artery disease (MI-CAD). However, data are still limited regarding long-term cardiovascular morbidity and cause-specific mortality in MINOCA. METHODS: This is a registry-based cohort study using data from patients admitted to Swedish coronary care units...
November 25, 2018: Journal of Internal Medicine
Paul M Ridker
Over the past 18 months, two multi-national clinical trials specifically designed to test the inflammation hypothesis of atherothrombosis have been presented. First, the 10,061 patient Canakinumab Anti-inflammatory Thrombosis Outcomes Study (CANTOS) proved that specific targeting of interleukin-1β can significantly reduce cardiovascular event rates in the absence of lipid or blood pressure lowering. In CANTOS, canakinumab given at doses of either 150 or 300 mg SC once every three months lowered the inflammatory biomarkers interleukin-6 and C-reactive protein (hsCRP) by 35 to 40 percent when compared to placebo, effects that led to a 17 percent reduction in rates of recurrent heart attack, stroke, urgent need for revascularization, or cardiovascular death (P<0...
November 25, 2018: Journal of Internal Medicine
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