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Journal of Internal Medicine

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https://www.readbyqxmd.com/read/28805259/al-amyloidosis-hypothyroidism-and-reduced-tissue-availability-of-thyroid-hormones-by-thyroid-hormone-binding-immunoglobulin-a-new-possible-perspective
#1
LETTER
Salvatore Benvenga, Fabrizio Guarneri
We read the interesting article by Muchtar et al. [1] on the prevalence of hypothyroidism in AL amyloidosis and its association with survival disadvantage. Particularly, hypothyroid patients had more frequent renal and hepatic involvement by amyloidosis, and a higher light chain burden than euthyroid patients. Uncited in their paper is that primary hypothyroidism is associated with increasing mortality [2], also in renal diseases. We hope to offer the authors a new perspective of viewing and interpreting their data...
August 14, 2017: Journal of Internal Medicine
https://www.readbyqxmd.com/read/28741859/inpatient-palliative-care-referral-and-9-month-hospital-readmission-in-patients-with-congestive-heart-failure-a-linked-nationwide-analysis
#2
Katie Wiskar, Leo Anthony Celi, Keith R Walley, Clark Fruhstorpher, Barret Rush
OBJECTIVE: End-stage heart failure (HF) is characterized by high symptom burden and frequent hospitalization. Palliative Care (PC) is recommended for advanced HF, and there is some evidence in other diseases that this may reduce readmission rates. We attempted examine the association of an inpatient PC visit on hospital readmission for patients admitted with HF. METHODS: Retrospective linked nationwide analysis from 2013 with 9-month follow-up for all hospital readmissions for patients admitted with HF exacerbations using the Nationwide Readmission Database (NRD)...
July 25, 2017: Journal of Internal Medicine
https://www.readbyqxmd.com/read/28734077/integrative-studies-implicate-matrix-metalloproteinase-12-as-a-culprit-gene-for-large-artery-atherosclerotic-stroke
#3
Hovsep Mahdessian, Ljubica Perisic Matic, Mariette Lengquist, Karl Gertow, Bengt Sennblad, Damiano Baldassarre, Fabrizio Veglia, Steve E Humphries, Rainer Rauramaa, Ulf de Faire, Andries J Smit, Philippe Giral, Sudhir Kurl, Elmo Mannarino, Elena Tremoli, Anders Hamsten, Per Eriksson, Ulf Hedin, Anders Mälarstig
BACKGROUND: Ischemic stroke and coronary heart disease are important contributors to the global disease burden and share atherosclerosis as the main underlying cause. Recent evidence from a genome-wide association study (GWAS) suggested that single nucleotide polymorphisms (SNP) near the MMP12 gene at chromosome 11q22.3 were associated with large-vessel ischemic stroke. Here we evaluated and extended these results by examining the relationship between MMP12 and atherosclerosis in clinical and experimental studies...
July 22, 2017: Journal of Internal Medicine
https://www.readbyqxmd.com/read/28730628/acute-hepatic-porphyria-and-cancer-risk-a-nationwide-cohort-study
#4
C M Baravelli, S Sandberg, A K Aarsand, R M Nilsen, M C Tollånes
BACKGROUND: Acute hepatic porphyria (AHP) is considered to be a risk factor for primary liver cancer (PLC), but varying risk estimates have been published. OBJECTIVES: Our aim was to investigate the risk of PLC and other cancers in persons with AHP using a nationwide cohort design. Given that greater numbers of women than men tend to have manifest and more severe AHP, a further aim was to investigate sex differences in this risk. METHODS: The study sample consisted of all Norwegian residents aged 18 years or older during the period 2000-2011...
July 20, 2017: Journal of Internal Medicine
https://www.readbyqxmd.com/read/28727206/the-mother-offspring-dyad-microbial-transmission-immune-interactions-and-allergy-development
#5
REVIEW
Maria C Jenmalm
The increasing prevalence of allergy in affluent countries may be caused by reduced intensity and diversity of microbial stimulation, resulting in abnormal postnatal immune maturation. Most studies investigating the underlying immunomodulatory mechanisms have focused on postnatal microbial exposure, for example demonstrating that the gut microbiota differs in composition and diversity during the first months of life in children who later do or do not develop allergic disease. However, it is also becoming increasingly evident that the maternal microbial environment during pregnancy is important in childhood immune programming, and the first microbial encounters may occur already in utero...
July 20, 2017: Journal of Internal Medicine
https://www.readbyqxmd.com/read/28727192/current-evidence-for-endovascular-therapy-in-stroke-and-remaining-uncertainties-r1
#6
REVIEW
Ronan Motyer, Hamed Asadi, John Thornton, Patrick Nicholson, Hong Kuan Kok
Class 1 level A evidence now supports endovascular thrombectomy as best practice in the management of large vessel occlusion acute ischemic stroke. However, significant questions pertaining to initial imaging, radiological assessment, patient selection and therapeutic limits remain unanswered. A specific cohort of patients who benefit from endovascular thrombectomy has been established, although current uncertainties regarding selection of those not meeting top-tier evidence criteria may potentially deny certain patients the benefit of intervention...
July 20, 2017: Journal of Internal Medicine
https://www.readbyqxmd.com/read/28714136/vitamin-d-and-bone-health-interpreting-observational-studies
#7
LETTER
T Sugiyama
No abstract text is available yet for this article.
July 17, 2017: Journal of Internal Medicine
https://www.readbyqxmd.com/read/28692172/effect-of-monthly-high-dose-vitamin-d-on-bone-density-in-community-dwelling-older-adults-sub-study-of-a-randomized-controlled-trial
#8
Ian R Reid, Anne M Horne, Borislav Mihov, Gregory D Gamble, Fadiya Al-Abuwsi, Manisha Singh, Lucie Taylor, Sheryl Fenwick, Carlos A Camargo, Alistair W Stewart, Robert Scragg
BACKGROUND: Severe vitamin D deficiency causes osteomalacia, yet trials of vitamin D supplementation in the community have not on average demonstrated benefit to bone mineral density (BMD) or fracture risk in adults. OBJECTIVE: To determine whether monthly high-dose vitamin D supplementation influences BMD in the general population and in those with low 25-hydroxyvitamin D levels. METHODS: 2-year sub-study of a trial in older community-resident adults...
July 10, 2017: Journal of Internal Medicine
https://www.readbyqxmd.com/read/28692139/the-health-threats-to-people-with-asthma-through-asthma-associated-infectious-disease-comorbidities-are-largely-under-recognized
#9
Young J Juhn
In this issue of Journal of Internal Medicine, Helby et al reported that compared to individuals without asthma or other atopic conditions, non-smokers with early asthma (<50 years of age) defined by self-report had increased risk of any infections (hazard ratio (HR) of 1.65, 95%CI: 1.40-1.94), pneumonia (HR of 2.44, 95%CI: 1.92-3.11), and non-respiratory tract infections (HR: 1.36, 95%CI: 1.11-1.67) defined by ICD codes in their large-scale prospective cohort study which followed 105,519 individuals from the general population of the City of Copenhagen, Denmark, for a median duration of 6 years(1) ...
July 10, 2017: Journal of Internal Medicine
https://www.readbyqxmd.com/read/28688111/vasopressin-and-metabolic-disorders-translation-from-experimental-models-to-clinical-use
#10
Kazuaki Nakamura, Gilberto Velho, Nadine Bouby
Vasopressin has many physiological actions in addition to its well-defined role in the control of fluid homeostasis and urine concentration. An increasing body of evidence suggests that the vasopressin-hydration axis plays a role in glucose homeostasis. This review summarizes the knowledge accumulated over the last decades about the influence of vasopressin in the short-term regulation of glycemia. It describes the possible role of this hormone through activation of V1a and V1b receptors on liver and pancreas functions and on the hypothalamic-pituitary-adrenal axis...
July 8, 2017: Journal of Internal Medicine
https://www.readbyqxmd.com/read/28682476/plasma-levels-of-hgf-and-plgf-predict-mortality-in-a-general-population-a-prospective-cohort-study
#11
Kristiina Santalahti, Aki Havulinna, Mikael Maksimow, Tanja Zeller, Stefan Blankenberg, Aki Vehtari, Heikki Joensuu, Sirpa Jalkanen, Veikko Salomaa, Marko Salmi
BACKGROUND: Circulating levels of growth factors involved in leukocyte production and angiogenesis could be indicative of underlying aberrations of tissue homeostasis and therefore be utilized as predictors of risk for all-cause cardiovascular disease (CVD) or cancer mortality. METHODS: Baseline plasma levels of a range of growth factors were measured in two cohorts of the population-based FINRISK study (1997 Discovery cohort, N=8444, aged 25-74; 2002 Replication cohort, N=2951, aged 51-74 years) using a multiplexed bead array methodology and ELISA...
July 6, 2017: Journal of Internal Medicine
https://www.readbyqxmd.com/read/28682471/impact-of-immunosuppressive-therapy-on-therapy-neutralizing-antibodies-in-transplanted-patients-with-fabry-disease
#12
M Lenders, D Oder, A Nowak, S Canaan-Kühl, L Arash-Kaps, C Drechsler, B Schmitz, P Nordbeck, J B Hennermann, C Kampmann, S Reuter, S-M Brand, C Wanner, E Brand
BACKGROUND: Inhibitory antibodies towards enzyme replacement therapy (ERT) are associated with disease progression and poor outcome in affected male patients with lysosomal disorders such as Fabry disease (FD). However, little is known about the impact of immunosuppressive therapy on ERT inhibition in these patients with FD. METHODS: In this retrospective study, we investigated the effect of long-term immunosuppression on ERT inhibition in male patients with FD (n = 26) receiving immunosuppressive therapy due to kidney (n = 24) or heart (n = 2) transplantation...
July 6, 2017: Journal of Internal Medicine
https://www.readbyqxmd.com/read/28649750/vasopressin-physiology-assessment-and-osmosensation
#13
L Bankir, D G Bichet, N G Morgenthaler
Vasopressin (AVP) plays a major role in the regulation of water and sodium homeostasis by its antidiuretic action on the kidney, mediated by V2 receptors. AVP secretion is stimulated by a rise in plasma osmolality, a decline in blood volume or stress. V1a receptors are expressed in vascular smooth muscle cells, but the role of vasopressin in blood pressure regulation is still a matter of debate. AVP may also play a role in some metabolic pathways, including gluconeogenesis, through its action on V1a receptors expressed in the liver...
June 25, 2017: Journal of Internal Medicine
https://www.readbyqxmd.com/read/28646607/more-pieces-of-the-fructose-puzzle
#14
Kimber L Stanhope
The involvement of fructose in cardiometabolic health continues to be a controversial topic. In just the last twelve months, there have been at least eight reviews published on the subject. Four of these reviews detailed mechanisms by which dietary fructose may have direct deleterious on effects on human health [1-4]. This article is protected by copyright. All rights reserved.
June 24, 2017: Journal of Internal Medicine
https://www.readbyqxmd.com/read/28643889/reply-to-letter-to-the-editor-regarding-the-article-should-we-treat-severe-vasovagal-syncope-with-a-pacemaker
#15
LETTER
Richard Sutton
First, I wish to thank the Southampton group for their interest in and compliments about the review (1). Second, I congratulate them on their approach to pacing in vasovagal syncope, using the leadless pacemaker. Their desire to limit, as far as possible, the complications of pacing in young vasovagal patients is praiseworthy. In my experience (unpublished) of around 30 patients of <40 years paced for vasovagal syncope, complications have been more frequent than in the older vasovagal patient and for pacing in more conventional indications...
June 23, 2017: Journal of Internal Medicine
https://www.readbyqxmd.com/read/28643850/the-role-of-leadless-single-chamber-pacemakers-in-the-treatment-of-vasovagal-syncope
#16
LETTER
Benedict M Wiles, Paul R Roberts
We read with great interest the excellent review by R. Sutton 'Should we treat severe vasovagal syncope with a pacemaker?' We agree that permanent cardiac pacing is only suitable for a tiny minority of patients with vasovagal syncope. At our institution we have a policy of avoiding pacing wherever possible in young patients due to the long term issues related to transvenous devices. However we do not necessarily agree that there is an acceptance that pacing for vasovagal syncope must be dual chamber, especially since the emergence of single chamber leadless pacemaker systems...
June 23, 2017: Journal of Internal Medicine
https://www.readbyqxmd.com/read/28635127/cardiovascular-risk-score-is-linked-to-subcutaneous-adipocyte-size-and-lipid-metabolism
#17
Mikael Rydén, Peter Arner
OBJECTIVE: Although white adipose tissue mass and distribution correlates with cardiovascular disease, the fat cell-specific perturbations underlying this association are not known. We determined the relationship between adipocyte size and lipid metabolism with cardiovascular risk. DESIGN/SUBJECTS: Adipocyte size as well as spontaneous (basal) and hormone-stimulated effects on adipocyte lipid metabolism (lipolysis and lipogenesis) were investigated in abdominal subcutaneous adipose tissue of 304 men and 775 women...
June 21, 2017: Journal of Internal Medicine
https://www.readbyqxmd.com/read/28631441/genetic-landscape-and-deregulated-pathways-in-b-cell-lymphoid-malignancies
#18
R Rosenquist, S Beà, M-Q Du, B Nadel, Q Pan-Hammarström
With the introduction of next-generation sequencing, the genetic landscape of the complex group of B-cell lymphoid malignancies has rapidly been unravelled in recent years. This has provided important information about recurrent genetic events and identified key pathways deregulated in each lymphoma subtype. In parallel, there has been intense search and development of novel types of targeted therapy that 'hit' central mechanisms in lymphoma pathobiology, such as BTK, PI3K or BCL2 inhibitors. In this review, we will outline the current view of the genetic landscape of selected entities: follicular lymphoma, diffuse large B-cell lymphoma, mantle cell lymphoma, chronic lymphocytic leukaemia and marginal zone lymphoma...
June 20, 2017: Journal of Internal Medicine
https://www.readbyqxmd.com/read/28621880/response-to-letter-to-the-editor-regarding-the-article-the-seasonal-importance-of-serum-25-hydroxyvitamin-d-for-bone-mineral-density-in-older-women
#19
LETTER
Karl Michaëlsson, Håkan Melhus
We thank dr Sugiyama for his thoughts regarding our publication [1]. These comments mainly deal with differences in physical activity as an underlying explanation for our findings and a null effect on BMD with vitamin D supplementation in meta-analyses of RCTs. We agree, that a more accurate definition of true vitamin D deficiency is needed. This article is protected by copyright. All rights reserved.
June 16, 2017: Journal of Internal Medicine
https://www.readbyqxmd.com/read/28574621/prospects-for-induction-of-cd8-t-cell-mediated-immunity-to-zika-virus-infection-by-yellow-fever-virus-vaccination
#20
K Blom, J T Sandberg, K Loré, H-G Ljunggren
No abstract text is available yet for this article.
June 2, 2017: Journal of Internal Medicine
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