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Journal of Internal Medicine

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https://www.readbyqxmd.com/read/28905441/the-vasopressin-system-new-insights-for-patients-with-kidney-diseases-epidemiological-evidence-and-therapeutic-perspectives
#1
W F Clark, O Devuyst, R Roussel
People with chronic kidney disease (CKD) are at risk of severe outcomes, such as end-stage renal disease or cardiovascular disease, and CKD is a globally increasing health burden with a high personal and economic cost. Despite major progresses in prevention and therapeutics in last decades, research is still needed to reverse this epidemic trend. The regulation of water balance and the state of activation of the vasopressin system have emerged as factors tightly associated with kidney health, in the general population but also in specific conditions; among them, various stages of CKD, diabetes and autosomal dominant polycystic kidney disease (ADPKD)...
September 14, 2017: Journal of Internal Medicine
https://www.readbyqxmd.com/read/28901035/how-much-vitamin-d-is-needed-for-healthy-bones
#2
R Bouillon
No abstract text is available yet for this article.
September 12, 2017: Journal of Internal Medicine
https://www.readbyqxmd.com/read/28881467/important-factors-affecting-the-choice-of-an-oral-anticoagulant-may-be-missed-in-database-studies
#3
LETTER
Emma Aarnio, Risto Huupponen, Maarit Jaana Korhonen
We read with great interest the article by Gundlund et al. 'Initiation of anticoagulation in atrial fibrillation: which factors are associated with choice of anticoagulant?' [1]. The authors characterized a cohort of more than 50,000 patients with atrial fibrillation (AF) who initiated warfarin or a non-vitamin K antagonist oral anticoagulant (NOAC; dabigatran, rivaroxaban or apixaban) during the period 2011-2016 using comprehensive Danish health databases. Characteristics of interest included patients' gender, age, CHA2 DS2 -VASc and HAS-BLED scores, comorbidities (e...
September 7, 2017: Journal of Internal Medicine
https://www.readbyqxmd.com/read/28881402/should-there-be-an-app-for-that-the-case-for-text-messaging-in-mhealth-interventions
#4
LETTER
Lindsay S Mayberry, Sarah S Jaser
The promise of mHealth (mobile health) is to reduce health disparities by increasing reach to patients who have fewer resources and have been historically difficult to engage. App- and web-based interventions are increasingly the focus of mHealth behavior change interventions.(1) Yet only a fraction of the 165,000 health-related apps (available as of 2015) are used; 12% of apps account for 90% of downloads.(2) Nonetheless, the number of health-related apps continues to increase exponentially. Recently, physicians and experts in behavior change have begun collaborating to create apps with greater promise for improving outcomes...
September 7, 2017: Journal of Internal Medicine
https://www.readbyqxmd.com/read/28875550/outcomes-of-endovascular-treatment-for-acute-large-vessel-ischemic-stroke-more-than-6-hours-after-symptom-onset
#5
Ronan Motyer, Hong Kuan Kok, Hamed Asadi, Alan O'Hare, Paul Brennan, Sarah Power, Seamus Looby, Patrick Nicholson, David Williams, Sean Murphy, Michael D Hill, Mayank Goyal, John McManus, Paul O'Brien, John Thornton
BACKGROUND AND OBJECTIVES: Benefit from endovascular thrombectomy (EVT) for large vessel occlusion (LVO) acute ischemic stroke (AIS) is well demonstrated. Furthermore, emerging evidence supports efficacy in appropriately selected patients treated beyond current recommendations of 6 hours. We evaluated clinical outcomes in patients undergoing late EVT at our institution. METHODS: Retrospective review of prospectively collected clinical database on 355 patients who underwent EVT for LVO AIS...
September 5, 2017: Journal of Internal Medicine
https://www.readbyqxmd.com/read/28875507/the-etiology-of-b-cell-lymphoid-malignancies-with-a-focus-on-chronic-inflammation-and-infections
#6
Karin E Smedby, Maurilio Ponzoni
B-cell malignancies are a heterogeneous group of lymphoproliferative disorders with different molecular characteristics and clinical course. It is increasingly recognized that the group displays considerable heterogeneity also regarding etiologic factors. Here, we summarize the latest developments in the etiology of B-cell lymphoid malignancy subtypes focusing on immune perturbation. Severe immune suppression constitues a strong and well established risk factor for aggressive subtypes (e.g., diffuse large B-cell and Burkitt lymphoma), but appears unrelated to risk of common low-grade subtypes (e...
September 5, 2017: Journal of Internal Medicine
https://www.readbyqxmd.com/read/28861933/desmosterol-accumulation-in-users-of-amiodarone
#7
Piia Simonen, Jukka Lehtonen, Anna-Maija Lampi, Vieno Piironen, Ulf-Håkan Stenman, Markku Kupari, Helena Gylling
BACKGROUND: Amiodarone is an effective and widely used antiarrhythmic drug with many possible adverse effects including hypercholesterolemia and hepatotoxicity. OBJECTIVE: Our aim was to evaluate how long-term amiodarone treatment affects cholesterol metabolism. METHODS: The study population consisted of 56 cardiac patients, of whom 20 were on amiodarone (amiodarone + group) and 36 did not use the drug (amiodarone - group). We also studied a control group of 124 individuals selected randomly from the population...
September 1, 2017: Journal of Internal Medicine
https://www.readbyqxmd.com/read/28861925/standard-and-reduced-doses-of-dabigatran-rivaroxaban-and-apixaban-for-stroke-prevention-in-atrial-fibrillation-a-nationwide-cohort-study
#8
Laila Staerk, Thomas A Gerds, Gregory Y H Lip, Brice Ozenne, Anders N Bonde, Morten Lamberts, Emil L Fosbøl, Christian Torp-Pedersen, Gunnar H Gislason, Jonas B Olesen
BACKGROUND: Comparative data of non-vitamin K antagonist oral anticoagulants (NOAC) are lacking in patients with atrial fibrillation (AF). OBJECTIVE: We compared effectiveness and safety of standard and reduced dose NOAC in AF patients. METHODS: Using Danish nationwide registries, we included all oral anticoagulant-naïve AF patients who initiated NOAC treatment (2012-2016). Outcome-specific and mortality-specific multiple Cox regressions were combined to compute average treatment effects as 1-year standardized differences in stroke and bleeding risks (g-formula)...
September 1, 2017: Journal of Internal Medicine
https://www.readbyqxmd.com/read/28861923/unraveling-hypothyroidism-in-al-amyloidosis-authors-reply
#9
Eli Muchtar, Morie Gertz
We read with interest the insightful comments by Benvenga and Guarneri (1) on our recently published paper which assessed the high prevalence of hypothyroidism among patients with immunoglobulin light chain (AL) amyloidosis.(2) The paper was the first research paper to address this topic in AL amyloidosis, so we appreciate any insights that can expand the understanding of this complex disease. Amyloidosis is an extremely heterogeneous disorder, and therefore various pathogenic mechanisms may play a role in organ dysfunction...
September 1, 2017: Journal of Internal Medicine
https://www.readbyqxmd.com/read/28857295/a-protective-role-of-irf3-and-irf7-signaling-downstream-tlrs-in-the-development-of-vein-graft-disease-via-type-i-interferons
#10
K H Simons, H A B Peters, J Wouter Jukema, M R de Vries, P H A Quax
BACKGROUND: Toll like receptors (TLR) play an important role in vein graft disease (VGD). Interferon regulatory factors (IRF) 3 and 7 are the transcriptional regulators of type-I interferons (IFN) and type-I IFN responsive genes and are downstream factors of TLRs. Relatively little is known with regard to the interplay of IRFs and TLRs in VGD development. The aim of this study was to investigate the role of IRF3 and IRF7 signaling downstream TLRs and the effect of IRF3 and IRF7 in VGD...
August 31, 2017: Journal of Internal Medicine
https://www.readbyqxmd.com/read/28857352/hip-fracture-risk-and-safety-with-alendronate-treatment-in-the-oldest-old
#11
K F Axelsson, M Wallander, H Johansson, D Lundh, M Lorentzon
BACKGROUND: There is high evidence for secondary prevention of fractures, including hip fracture, with alendronate treatment, but alendronate's efficacy to prevent hip fractures in the oldest-old (≥80 years old), the population with the highest fracture risk, has not been studied. OBJECTIVE: To investigate if alendronate treatment among the oldest old with prior fracture was related to decreased hip fracture rate and sustained safety. METHODS: Using a national database of men and women undergoing a fall risk assessment at a Swedish healthcare facility, we identified 90 795 patients who were 80 years or older and had a prior fracture...
August 30, 2017: Journal of Internal Medicine
https://www.readbyqxmd.com/read/28842933/plasma-stem-cell-factor-levels-are-associated-with-risk-of-cardiovascular-disease-and-death
#12
Harry Björkbacka, Ingrid Yao Mattisson, Maria Wigren, Olle Melander, Gunilla Nordin Fredrikson, Eva Bengtsson, Isabel Gonçalves, Peter Almgren, Jens O Lagerstedt, Marju Orho-Melander, Gunnar Engström, Jan Nilsson
OBJECTIVE: Stem cell factor (SCF) is a key growth factor for several types of stem and progenitor cells. There is experimental evidence that such cells are of importance for maintaining the integrity of the cardiovascular system. We investigated the association between circulating levels of SCF and risk for development of cardiovascular events and death. METHODS: SCF was analyzed by the Proximity Extension Assay technique in plasma from 4742 subjects participating in the Malmö Diet and Cancer Study...
August 26, 2017: Journal of Internal Medicine
https://www.readbyqxmd.com/read/28805259/al-amyloidosis-hypothyroidism-and-reduced-tissue-availability-of-thyroid-hormones-by-thyroid-hormone-binding-immunoglobulin-a-new-possible-perspective
#13
LETTER
Salvatore Benvenga, Fabrizio Guarneri
We read the interesting article by Muchtar et al. [1] on the prevalence of hypothyroidism in AL amyloidosis and its association with survival disadvantage. Particularly, hypothyroid patients had more frequent renal and hepatic involvement by amyloidosis, and a higher light chain burden than euthyroid patients. Uncited in their paper is that primary hypothyroidism is associated with increasing mortality [2], also in renal diseases. We hope to offer the authors a new perspective of viewing and interpreting their data...
August 14, 2017: Journal of Internal Medicine
https://www.readbyqxmd.com/read/28741859/inpatient-palliative-care-referral-and-9-month-hospital-readmission-in-patients-with-congestive-heart-failure-a-linked-nationwide-analysis
#14
K Wiskar, L A Celi, K R Walley, C Fruhstorfer, B Rush
OBJECTIVE: End-stage heart failure (HF) is characterized by high symptom burden and frequent hospitalization. Palliative care (PC) is recommended for advanced HF, and there is some evidence in other diseases that this may reduce readmission rates. We attempted examine the association of an inpatient PC visit on hospital readmission for patients admitted with HF. METHODS: Retrospective linked nationwide analysis from 2013 with 9-month follow-up for all hospital readmissions for patients admitted with HF exacerbations using the Nationwide Readmission Database (NRD)...
July 25, 2017: Journal of Internal Medicine
https://www.readbyqxmd.com/read/28734077/integrative-studies-implicate-matrix-metalloproteinase-12-as-a-culprit-gene-for-large-artery-atherosclerotic-stroke
#15
Hovsep Mahdessian, Ljubica Perisic Matic, Mariette Lengquist, Karl Gertow, Bengt Sennblad, Damiano Baldassarre, Fabrizio Veglia, Steve E Humphries, Rainer Rauramaa, Ulf de Faire, Andries J Smit, Philippe Giral, Sudhir Kurl, Elmo Mannarino, Elena Tremoli, Anders Hamsten, Per Eriksson, Ulf Hedin, Anders Mälarstig
BACKGROUND: Ischemic stroke and coronary heart disease are important contributors to the global disease burden and share atherosclerosis as the main underlying cause. Recent evidence from a genome-wide association study (GWAS) suggested that single nucleotide polymorphisms (SNP) near the MMP12 gene at chromosome 11q22.3 were associated with large-vessel ischemic stroke. Here we evaluated and extended these results by examining the relationship between MMP12 and atherosclerosis in clinical and experimental studies...
July 22, 2017: Journal of Internal Medicine
https://www.readbyqxmd.com/read/28727206/the-mother-offspring-dyad-microbial-transmission-immune-interactions-and-allergy-development
#16
REVIEW
Maria C Jenmalm
The increasing prevalence of allergy in affluent countries may be caused by reduced intensity and diversity of microbial stimulation, resulting in abnormal postnatal immune maturation. Most studies investigating the underlying immunomodulatory mechanisms have focused on postnatal microbial exposure, for example demonstrating that the gut microbiota differs in composition and diversity during the first months of life in children who later do or do not develop allergic disease. However, it is also becoming increasingly evident that the maternal microbial environment during pregnancy is important in childhood immune programming, and the first microbial encounters may occur already in utero...
July 20, 2017: Journal of Internal Medicine
https://www.readbyqxmd.com/read/28727192/current-evidence-for-endovascular-therapy-in-stroke-and-remaining-uncertainties-r1
#17
REVIEW
Ronan Motyer, Hamed Asadi, John Thornton, Patrick Nicholson, Hong Kuan Kok
Class 1 level A evidence now supports endovascular thrombectomy as best practice in the management of large vessel occlusion acute ischemic stroke. However, significant questions pertaining to initial imaging, radiological assessment, patient selection and therapeutic limits remain unanswered. A specific cohort of patients who benefit from endovascular thrombectomy has been established, although current uncertainties regarding selection of those not meeting top-tier evidence criteria may potentially deny certain patients the benefit of intervention...
July 20, 2017: Journal of Internal Medicine
https://www.readbyqxmd.com/read/28692172/effect-of-monthly-high-dose-vitamin-d-on-bone-density-in-community-dwelling-older-adults-substudy-of-a-randomized-controlled-trial
#18
I R Reid, A M Horne, B Mihov, G D Gamble, F Al-Abuwsi, M Singh, L Taylor, S Fenwick, C A Camargo, A W Stewart, R Scragg
BACKGROUND: Severe vitamin D deficiency causes osteomalacia, yet trials of vitamin D supplementation in the community have not on average demonstrated benefit to bone mineral density (BMD) or fracture risk in adults. OBJECTIVE: To determine whether monthly high-dose vitamin D supplementation influences BMD in the general population and in those with low 25-hydroxyvitamin D levels. METHODS: Two-year substudy of a trial in older community-resident adults...
July 10, 2017: Journal of Internal Medicine
https://www.readbyqxmd.com/read/28688111/vasopressin-and-metabolic-disorders-translation-from-experimental-models-to-clinical-use
#19
Kazuaki Nakamura, Gilberto Velho, Nadine Bouby
Vasopressin has many physiological actions in addition to its well-defined role in the control of fluid homeostasis and urine concentration. An increasing body of evidence suggests that the vasopressin-hydration axis plays a role in glucose homeostasis. This review summarizes the knowledge accumulated over the last decades about the influence of vasopressin in the short-term regulation of glycemia. It describes the possible role of this hormone through activation of V1a and V1b receptors on liver and pancreas functions and on the hypothalamic-pituitary-adrenal axis...
July 8, 2017: Journal of Internal Medicine
https://www.readbyqxmd.com/read/28682476/plasma-levels-of-hgf-and-plgf-predict-mortality-in-a-general-population-a-prospective-cohort-study
#20
Kristiina Santalahti, Aki Havulinna, Mikael Maksimow, Tanja Zeller, Stefan Blankenberg, Aki Vehtari, Heikki Joensuu, Sirpa Jalkanen, Veikko Salomaa, Marko Salmi
BACKGROUND: Circulating levels of growth factors involved in leukocyte production and angiogenesis could be indicative of underlying aberrations of tissue homeostasis and therefore be utilized as predictors of risk for all-cause cardiovascular disease (CVD) or cancer mortality. METHODS: Baseline plasma levels of a range of growth factors were measured in two cohorts of the population-based FINRISK study (1997 Discovery cohort, N=8444, aged 25-74; 2002 Replication cohort, N=2951, aged 51-74 years) using a multiplexed bead array methodology and ELISA...
July 6, 2017: Journal of Internal Medicine
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