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Journal of Internal Medicine

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https://www.readbyqxmd.com/read/27991731/novel-treatment-concepts-in-hodgkin-lymphoma
#1
REVIEW
I Glimelius, A Diepstra
Treatment of classical Hodgkin's lymphoma (HL) has been a success story, with cure of localized disease with radiotherapy in the 1930s, cure of advanced stages with combination chemotherapy with/without radiotherapy in the mid-1960s and continuous improvements since then. Nonetheless, at present approximately 2% of patients with classical HL are primarily refractory to conventional therapy with only 50% becoming long-term survivors. Another 13% of patients relapse, with only 60% being alive 10 years postrecurrence (as exemplified in this review in a Swedish cohort of 18- to 65-year-old patients diagnosed during the period 1992-2009)...
December 19, 2016: Journal of Internal Medicine
https://www.readbyqxmd.com/read/27991713/roles-of-the-gut-in-the-metabolic-syndrome-an-overview
#2
REVIEW
L Fändriks
The metabolic syndrome is a cluster of risk factors (central obesity, hyperglycaemia, dyslipidaemia and arterial hypertension), indicating an increased risk of diabetes, cardiovascular disease and premature mortality. The gastrointestinal tract is seldom discussed as an organ system of principal importance for metabolic diseases. The present overview connects various metabolic research lines into an integrative physiological context in which the gastrointestinal tract is included. Strong evidence for the involvement of the gut in the metabolic syndrome derives from the powerful effects of weight-reducing (bariatric) gastrointestinal surgery...
December 19, 2016: Journal of Internal Medicine
https://www.readbyqxmd.com/read/27933671/causal-inference-in-obesity-research
#3
REVIEW
P W Franks, N Atabaki-Pasdar
Obesity is a risk factor for a plethora of severe morbidities and premature death. Most supporting evidence comes from observational studies that are prone to chance, bias and confounding. Even data on the protective effects of weight loss from randomized controlled trials will be susceptible to confounding and bias if treatment assignment cannot be masked, which is usually the case with lifestyle and surgical interventions. Thus, whilst obesity is widely considered the major modifiable risk factor for many chronic diseases, its causes and consequences are often difficult to determine...
December 8, 2016: Journal of Internal Medicine
https://www.readbyqxmd.com/read/27926979/erythropoiesis-stimulating-agents-significantly-delay-the-onset-of-a-regular-transfusion-need-in-nontransfused-patients-with-lower-risk-myelodysplastic-syndrome
#4
H K G Garelius, W T Johnston, A G Smith, S Park, L de Swart, P Fenaux, A Symeonidis, G Sanz, J Čermák, R Stauder, L Malcovati, M Mittelman, A A van de Loosdrecht, C J van Marrewijk, D Bowen, S Crouch, T J M de Witte, E Hellström-Lindberg
BACKGROUND: The EUMDS registry is an unique prospective, longitudinal observational registry enrolling newly diagnosed patients with lower-risk myelodysplastic syndrome (MDS) from 17 European countries from both university hospitals and smaller regional hospitals. OBJECTIVE: The aim of this study was to describe the usage and clinical impact of erythropoiesis-stimulating agents (ESAs) in 1696 patients enrolled between 2008 and 2014. METHODS: The effects of ESAs on outcomes were assessed using proportional hazards models weighting observations by propensity to receive ESA treatment within a subset of anaemic patients with or without a regular transfusion need...
December 7, 2016: Journal of Internal Medicine
https://www.readbyqxmd.com/read/27925333/glycaemic-control-and-excess-risk-of-ischaemic-and-haemorrhagic-stroke-in-patients-with-type-1-diabetes-a-cohort-study-of-33-453-patients
#5
C Hedén Ståhl, M Lind, A-M Svensson, S Gudbjörnsdottir, A Mårtensson, A Rosengren
OBJECTIVE: To estimate the excess risk of stroke in relation to glycaemic control in patients with type 1 diabetes. METHODS: In this prospective, matched cohort study, we identified patients with type 1 diabetes, aged ≥18 years, who were registered in the Swedish National Diabetes Register from 1998-2011 and five control subjects for each case from the general population, matched for age, sex and county of residence. The risks of all strokes, ischaemic stroke and haemorrhagic stroke were estimated using Cox hazard regression...
December 7, 2016: Journal of Internal Medicine
https://www.readbyqxmd.com/read/27878865/fibroblast-growth-factor-21-night-watch-advances-and-uncertainties-in-the-field
#6
REVIEW
A Kharitonenkov, R DiMarchi
Fibroblast growth factor (FGF) 21 belongs to a hormone-like subgroup within the FGF superfamily. The members of this subfamily, FGF19, FGF21 and FGF23, are characterized by their reduced binding affinity for heparin that enables them to be transported in the circulation and function in an endocrine manner. It is likely that FGF21 also acts in an autocrine and paracrine fashion, as multiple organs can produce this protein and its plasma concentration seems to be below the level necessary to induce a pharmacological effect...
November 22, 2016: Journal of Internal Medicine
https://www.readbyqxmd.com/read/27864858/authors-response-letter-to-the-editor-hpv-vaccine-and-autoimmunity
#7
LETTER
O Grönlund, E Herweijer, K Sundström, L Arnheim-Dahlström
No abstract text is available yet for this article.
November 18, 2016: Journal of Internal Medicine
https://www.readbyqxmd.com/read/27864851/letter-to-the-editor-hpv-vaccine-and-autoimmunity-incidence-of-new-onset-autoimmune-disease-in-girls-and-women-with-pre-existing-autoimmune-disease-after-quadrivalent-human-papillomavirus-vaccination-a-cohort-study
#8
LETTER
https://www.readbyqxmd.com/read/27862491/alarmins-and-central-nervous-system-inflammation-in-hiv-associated-neurological-disorders
#9
M-L Gougeon
In the era of highly active antiretroviral therapy (HAART), HIV-1-associated neurocognitive disorders (HAND) persist in infected individuals with adequate immunological and virological status. Risk factors for cognitive impairment include hepatitis C virus co-infection, host genetic factors predisposing to HAND, the early establishment of the virus in the CNS and its persistence under HAART; thus, the CNS is an important reservoir for HIV. Microglial cells are permissive to HIV-1, and NLRP3 inflammasome-associated genes were found expressed in brains of HIV-1-infected persons, contributing to brain disease...
November 16, 2016: Journal of Internal Medicine
https://www.readbyqxmd.com/read/27862464/randomized-assessment-of-imatinib-in-patients-with-acute-ischaemic-stroke-treated-with-intravenous-thrombolysis
#10
N Wahlgren, M Thorén, B Höjeberg, T-B Käll, A-C Laska, C Sjöstrand, J Höijer, H Almqvist, S Holmin, A Lilja, L Fredriksson, D Lawrence, U Eriksson, N Ahmed
BACKGROUND: Imatinib, a tyrosine kinase inhibitor, has been shown to restore blood-brain barrier integrity and reduce infarct size, haemorrhagic transformation and cerebral oedema in stroke models treated with tissue plasminogen activator. We evaluated the safety of imatinib, based on clinical and neuroradiological data, and its potential influence on neurological and functional outcomes. METHODS: A phase II randomized trial was performed in patients with acute ischaemic stroke treated with intravenous thrombolysis...
November 14, 2016: Journal of Internal Medicine
https://www.readbyqxmd.com/read/27862475/treatment-of-idiopathic-pulmonary-fibrosis-a-position-paper-from-a-nordic-expert-group
#11
REVIEW
C M Sköld, E Bendstrup, M Myllärniemi, G Gudmundsson, T Sjåheim, O Hilberg, A Altraja, R Kaarteenaho, G Ferrara
Idiopathic pulmonary fibrosis (IPF) is a fatal progressive lung disease occurring in adults. In the last decade, the results of a number of clinical trials based on the updated disease classification have been published. The registration of pirfenidone and nintedanib, the first two pharmacological treatment options approved for IPF, marks a new chapter in the management of patients with this disease. Other nonpharmacological treatments such as lung transplantation, rehabilitation and palliation have also been shown to be beneficial for these patients...
November 13, 2016: Journal of Internal Medicine
https://www.readbyqxmd.com/read/27807919/extended-exome-sequencing-identifies-bach2-as-a-novel-major-risk-locus-for-addison-s-disease
#12
D Eriksson, M Bianchi, N Landegren, J Nordin, F Dalin, A Mathioudaki, G N Eriksson, L Hultin-Rosenberg, J Dahlqvist, H Zetterqvist, Å Karlsson, Å Hallgren, F H G Farias, E Murén, K M Ahlgren, A Lobell, G Andersson, K Tandre, S R Dahlqvist, P Söderkvist, L Rönnblom, A-L Hulting, J Wahlberg, O Ekwall, P Dahlqvist, J R S Meadows, S Bensing, K Lindblad-Toh, O Kämpe, G R Pielberg
BACKGROUND: Autoimmune disease is one of the leading causes of morbidity and mortality worldwide. In Addison's disease, the adrenal glands are targeted by destructive autoimmunity. Despite being the most common cause of primary adrenal failure, little is known about its aetiology. METHODS: To understand the genetic background of Addison's disease, we utilized the extensively characterized patients of the Swedish Addison Registry. We developed an extended exome capture array comprising a selected set of 1853 genes and their potential regulatory elements, for the purpose of sequencing 479 patients with Addison's disease and 1394 controls...
November 2, 2016: Journal of Internal Medicine
https://www.readbyqxmd.com/read/27766700/use-of-statins-offsets-insulin-related-cancer-risk
#13
A Kautzky-Willer, S Thurner, P Klimek
AIM: There is firm evidence of a relation between type 2 diabetes (T2DM) and increased risks of cancer at various sites, but it is still unclear how different antihyperglycaemic therapies modify site-specific cancer risks. The aim of this study was to provide a complete characterization of all possible associations between individual T2DM therapies, statin use and site-specific cancers in the Austrian population. METHODS: Medical claims data of 1 847 051 patients with hospital stays during 2006-2007 were used to estimate age- and sex-dependent co-occurrences of site-specific cancer diagnoses and treatment with specific glucose-lowering drugs and statins...
October 21, 2016: Journal of Internal Medicine
https://www.readbyqxmd.com/read/27995694/response-to-letter-from-lars-andersson
#14
LETTER
I Persson, N Feltelius
No abstract text is available yet for this article.
January 2017: Journal of Internal Medicine
https://www.readbyqxmd.com/read/27995693/risks-of-neurological-and-immune-related-diseases-including-narcolepsy-after-vaccination-with-pandemrix-a-population-and-registry-based-cohort-study-with-over-2%C3%A2-years-of-follow-up
#15
I Persson, F Granath, J Askling, J F Ludvigsson, T Olsson, N Feltelius
No abstract text is available yet for this article.
January 2017: Journal of Internal Medicine
https://www.readbyqxmd.com/read/27995692/c-peptide-and-the-pathophysiology-of-microvascular-complications-of-diabetes
#16
J Wahren
No abstract text is available yet for this article.
January 2017: Journal of Internal Medicine
https://www.readbyqxmd.com/read/27995691/hidden-authority-study-data-have-come-to-light-besides-narcolepsy-the-swine-influenza-vaccine-pandemrix-caused-type-1-diabetes
#17
LETTER
L Andersson
No abstract text is available yet for this article.
January 2017: Journal of Internal Medicine
https://www.readbyqxmd.com/read/27640884/c-peptide-and-diabetic-kidney-disease
#18
N J Brunskill
Kidney disease is a serious development in diabetes mellitus and poses an increasing clinical problem. Despite increasing incidence and prevalence of diabetic kidney disease, there have been no new therapies for this condition in the last 20 years. Mounting evidence supports a biological role for C-peptide, and findings from multiple studies now suggest that C-peptide may beneficially affect the disturbed metabolic and pathophysiological pathways leading to the development of diabetic nephropathy. Studies of C-peptide in animal models and in humans with type 1 diabetes all suggest a renoprotective effect for this peptide...
January 2017: Journal of Internal Medicine
https://www.readbyqxmd.com/read/27601091/fish-consumption-and-all-cause-mortality-in-a-cohort-of-swedish-men-and-women
#19
A Bellavia, S C Larsson, A Wolk
BACKGROUND: Epidemiological studies of fish consumption and all-cause mortality have provided inconsistent results. OBJECTIVE: We examined the dose-response association between fish consumption and mortality from all causes in a large population-based cohort of Swedish men and women. METHODS: The study included 72 522 participants (33 973 women and 38 549 men), aged 45-83 years, from the Swedish Mammography Cohort and the Cohort of Swedish Men...
January 2017: Journal of Internal Medicine
https://www.readbyqxmd.com/read/27485145/ten-year-alcohol-consumption-typologies-and-trajectories-of-c-reactive-protein-interleukin-6-and-interleukin-1-receptor-antagonist-over-the-following-12-years-a-prospective-cohort-study
#20
S Bell, G Mehta, K Moore, A Britton
BACKGROUND: Moderate alcohol consumption is thought to confer cardiometabolic protective effects. Inflammatory pathways are hypothesized to partly underlie this association. OBJECTIVES: The aim of this study was to examine the association between typologies of alcohol consumption and markers of inflammation, and their rate of change over time. METHODS: Data were collected from 8209 participants [69% men; mean age, 50 years (SD 6.1)] of the British Whitehall II study...
January 2017: Journal of Internal Medicine
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