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Journal of Internal Medicine

M C Cornelis, I Erlund, G A Michelotti, C Herder, J A Westerhuis, J Tuomilehto
BACKGROUND: Coffee is widely consumed and contains many bioactive compounds, any of which may impact pathways related to disease development. OBJECTIVE: To identify individual metabolite changes in response to coffee. METHODS: We profiled the metabolome of fasting serum samples collected from a previously reported single-blinded, three-stage clinical trial. Forty-seven habitual coffee consumers refrained from drinking coffee for 1 month, consumed four cups of coffee/day in the second month and eight cups/day in the third month...
March 15, 2018: Journal of Internal Medicine
Helle Km Bergholdt, Morten K Larsen, Anette Varbo, Børge G Nordestgaard, Christina Ellervik
BACKGROUND: Whether a causal relationship exists between milk intake and reduced risk of fractures is unclear. OBJECTIVES: We tested the hypothesis that genetically determined milk intake reduces the risk of fractures and increases bone mineral density(BMD). METHODS: We investigated the association between milk intake, LCT-13910 C/T (rs4988235) which is associated with lactase persistence (TT/TC) in Northern Europeans, and hip fractures in three Danish prospective studies(N=97,811,age ≥20 years)...
March 14, 2018: Journal of Internal Medicine
J M Kindblom, M Bygdell, A Sondén, J Célind, A Rosengren, C Ohlsson
AIM: Hospitalization for heart failure amongst younger men has increased. The reason for this is unknown but it coincides with the obesity epidemic. The aim of this study was to evaluate the association between childhood BMI (Body Mass Index) and BMI change during puberty for risk of adult heart failure in men. METHODS: Using the BMI Epidemiology Study (BEST), a population-based study in Gothenburg, Sweden, we collected information on childhood BMI at age 8 years and BMI change during puberty (BMI at age 20 - BMI at 8) for men born 1945-1961, followed until December 2013 (n = 37 670)...
March 12, 2018: Journal of Internal Medicine
I Arias de la Rosa, A Escudero-Contreras, S Rodríguez-Cuenca, M Ruiz-Ponce, Y Jiménez-Gómez, P Ruiz-Limón, C Pérez-Sánchez, M C Ábalos-Aguilera, I Cecchi, R Ortega, J Calvo, R Guzmán-Ruiz, M M Malagón, E Collantes-Estevez, A Vidal-Puig, Ch López-Pedrera, N Barbarroja
BACKGROUND: Rheumatoid arthritis (RA) patients are at increased risk of insulin resistance (IR); however, the specific mechanisms mediating this association are currently unknown. OBJECTIVE: To investigate whether the inflammatory activity associated with RA accounts for the observed defective glucose metabolism and lipid metabolism in these patients. METHODS: We followed two main strategies: (i) extensive metabolic profiling of a RA cohort of 100 patients and 50 healthy control subjects and (ii) mechanistic studies carried out in both a collagen-induced arthritis mouse model and 3T3-L1 adipocytes treated with conditioned serum from RA patients...
March 12, 2018: Journal of Internal Medicine
S Olafsson, T Tyrfingsson, V Runarsdottir, O M Bergmann, I Hansdottir, E S Björnsson, B Johannsson, B Sigurdardottir, R H Fridriksdottir, A Löve, M Hellard, T J Löve, T Gudnason, M Heimisdottir, M Gottfredsson
A nationwide programme for the treatment of all patients infected with hepatitis C virus (HCV) was launched in Iceland in January 2016. By providing universal access to direct-acting antiviral agents to the entire patient population, the two key aims of the project were to (i) offer a cure to patients and thus reduce the long-term sequelae of chronic hepatitis C, and (ii) to reduce domestic incidence of HCV in the population by 80% prior to the WHO goal of HCV elimination by the year 2030. An important part of the programme is that vast majority of cases will be treated within 36 months from the launch of the project, during 2016-2018...
March 7, 2018: Journal of Internal Medicine
Colin P West, Liselotte N Dyrbye, Tait D Shanafelt
Physician burnout, a work-related syndrome involving emotional exhaustion, depersonalization, and a sense of reduced personal accomplishment, is prevalent internationally. Rates of burnout symptoms that have been associated with adverse effects on patients, the health care workforce, costs, and physician health exceed 50% in studies of both physicians-in-training and practicing physicians. This problem represents a public health crisis with negative impacts on individual physicians, patients, and health care organizations and systems...
March 5, 2018: Journal of Internal Medicine
Caroline Schmitt, Hugo Lenglet, Angèle Yu, Constance Delaby, Arndt Benecke, Thibaud Lefebvre, Philippe Letteron, Valérie Paradis, Staffan Wahlin, Sverre Sandberg, Pauline Harper, Eliane Sardh, Arne Kristian Sandvik, Johannes R Hov, Aasne Karine Aarsand, Laurence Chiche, Céline Bazille, Jean-Yves Scoazec, Jordi To Figueras, Montserrat Carrascal, Joaquim Abian, Arienne Mirmiran, Zoubida Karim, Jean-Charles Deybach, Hervé Puy, Katell Peoc'h, Hana Manceau, Laurent Gouya
BACKGROUND: Acute intermittent porphyria (AIP) is an inherited disorder of heme metabolism characterized by life-threatening acute neurovisceral attacks due to the induction of hepatic δ-aminolevulinic acid synthase 1 (ALAS1) associated with hydroxymethylbilane synthase (HMBS) deficiency. So far, the treatment of choice is hemin which represses ALAS1. The main issue in the medical care of AIP patients is the occurrence of debilitating recurrent attacks. OBJECTIVE: The aim of this study was to determine whether chronic hemin administration contributes to the recurrence of acute attacks...
March 2, 2018: Journal of Internal Medicine
Rebecca Troisi, Tone Bjørge, Mika Gissler, Tom Grotmol, Cari M Kitahara, Solbjørg Makalani Myrtveit Saether, Anne Gulbech Ording, Camilla Sköld, Henrik Toft Sørensen, Britton Trabert, Ingrid Glimelius
An understanding of the origin of cancer is critical for cancer prevention and treatment. Complex biological mechanisms promote carcinogenesis, and there is increasing evidence that pregnancy-related exposures influence fetal growth cell division and organ functioning and may have a long-lasting impact on health and disease susceptibility in the mothers and offspring. Nulliparity is an established risk factor for breast, ovarian, endometrial, and possibly pancreatic cancer, while the risk of kidney cancer is elevated in parous compared with nulliparous women...
February 24, 2018: Journal of Internal Medicine
J-Matthias Löhr, Nikola Panic, Miroslav Vujasinovic, Caroline S Verbeke
Senior people constitute the fastest growing segment of the population. The elderly are at risk for malnutrition, thought to be caused by reduced food intake or involution of the physiological capacity of the GI tract. Age-related changes are well known in other secretory organs such as liver, kidney, and intestine. The pancreas, representing a metabolically active organ with uptake and breakdown of essential nutritional components, changes its morphology and function with age. During childhood, the volume of the pancreas increases, reaching a plateau between 20-60 years, and declines thereafter...
February 23, 2018: Journal of Internal Medicine
Brittany L Adler, Maryam K Pezhouh, Amy Kim, Lan Luan, Qingfeng Zhu, Faiz Gani, Mark Yarchoan, Jonathan Chen, Lysandra Voltaggio, Alyssa Parian, Mark Lazarev, Gregory Y Lauwers, Timothy M Pawlik, Elizabeth A Montgomery, Elizabeth Jaffee, Dung T Le, Janis M Taube, Robert A Anders
BACKGROUND: Use of the immune checkpoint inhibitor ipilimumab is sometimes complicated by ipilimumab-associated colitis (Ipi-AC), an immune-mediated colitis that mimics inflammatory bowel disease. OBJECTIVE: We sought to characterize the histopathologic and immunophenotypic features of Ipi-AC, and to directly compare these features to ulcerative colitis (UC). METHODS: This is a retrospective cohort study of 22 patients with Ipi-AC, 12 patients with treatment-naïve UC, and 5 controls with diarrhea but normal endoscopic findings...
February 21, 2018: Journal of Internal Medicine
Aldo Bonaventura, Fabrizio Montecucco
Pathophysiological evidences on ischemic stroke (IS) indicate a critical involvement of post-ischemic inflammation in determining neuronal injury. In last decades, several inflammatory molecules have been investigated as potential diagnostic and/or prognostic tools. At present, however, no specific pathophysiological factor has been identified for being recommended in the clinical management of the disease. This article is protected by copyright. All rights reserved.
February 14, 2018: Journal of Internal Medicine
A I Nagy, C Hage, B Merkely, E Donal, J-C Daubert, C Linde, L H Lund, A Manouras
AIMS: Left ventricular (LV) mechanics have been extensively investigated in heart failure with preserved ejection fraction (HFpEF) overshadowing for a long time the potential role of left atrium (LA) in that setting. Soluble suppression of tumorigenicity-2 receptor (ST2) is a novel biomarker of pro-fibrotic burden in HF. We hypothesized that due to the thinner LA wall, the fibrotic myocardial changes in HFpEF as indicated by elevated ST2 levels might more readily be reflected by impairments in the LA rather than the LV performance...
February 12, 2018: Journal of Internal Medicine
Alba Simats, Teresa García-Berrocoso, Anna Penalba, Dolors Giralt, Gemma Llovera, Yinghua Jiang, Laura Ramiro, Alejandro Bustamante, Elena Martinez-Saez, Francesc Canals, Xiaoying Wang, Arthur Liesz, Anna Rosell, Joan Montaner
BACKGROUND: CCL23 role in the inflammatory response after acute brain injuries remains elusive. Here, we evaluated whether CCL23 blood levels associate with acquired cerebral lesions and determined CCL23 predictive capacity for assessing stroke prognosis. We used pre-clinical models to study the CCL23 homologous chemokines in rodents, CCL9 and CCL6. METHODS: Baseline CCL23 blood levels were determined on 245 individuals, including ischemic strokes (IS), stroke-mimics and controls...
February 7, 2018: Journal of Internal Medicine
Amaia Calderón-Larrañaga, Giola Santoni, Hui Xin Wang, Anna-Karin Welmer, Debora Rizzuto, Davide L Vetrano, Alessandra Marengoni, Laura Fratiglioni
BACKGROUND: Multimorbidity is among the most disabling geriatric conditions. In this study we explored whether a rapid development of multimorbidity potentiates its impact on the functional independence of older adults, and whether different sociodemographic factors play a role beyond the rate of chronic disease accumulation. METHODS: A random sample of persons aged ≥60 years (n = 2387) from the Swedish National study on Aging and Care in Kungsholmen (SNAC-K) was followed over 6 years...
February 7, 2018: Journal of Internal Medicine
Amanda J Berberich, Robert A Hegele
No abstract text is available yet for this article.
February 2, 2018: Journal of Internal Medicine
Alfred K Cheung, Glenn M Chertow, Tom Greene, Paul L Kimmel, Mahboob Rahman, David Reboussin, Michael Rocco
We read with interest the article by Obi, et al. published in J Intern Med [1]. These Authors performed a post-hoc analysis of the Systolic Blood Pressure Intervention Trial (SPRINT). They reported an interaction, with unadjusted p-value = 0.019, between baseline estimated glomerular filtration rate (eGFR) and randomization to the lower systolic blood pressure (SBP) goal of <120 mm Hg on the primary cardiovascular outcome, when a linear relationship was assumed between the effect of the treatment and baseline eGFR...
January 31, 2018: Journal of Internal Medicine
Yoshitsugu Obi, Kamyar Kalantar-Zadeh, Ayumi Shintani, Csaba P Kovesdy, Takayuki Hamano
We thank Dr. A. Cheung and his colleagues from the SPRINT Research group for their letter-to-the-editor [1] about our study.[2] Their main criticisms included the statistical power of our study (especially in the subgroups of patients with eGFR <45 ml/min/1.73m2 ) and the issue of multiple comparisons. In our rebuttal, we take the advantage of this opportunity to clarify several core concepts of our study, highlighting the heterogeneity within the chronic kidney disease (CKD) spectrum and the statistical methods used to evaluate treatment effect modifications...
January 27, 2018: Journal of Internal Medicine
Babak Hooshmand, Tuomo Polvikoski, Miia Kivipelto, Maarit Tanskanen, Liisa Myllykangas, Mira Mäkelä, Minna Oinas, Anders Paetau, Alina Solomon
BACKGROUND: CAIDE Dementia Risk Score is a tool for estimating dementia risk in the general population. Its longitudinal associations with Alzheimer or vascular neuropathology in the oldest old are not known. AIM: To explore the relationship between CAIDE Dementia Risk Score at baseline and neuritic plaques, neurofibrillary tangles, cerebral infarcts, and cerebral amyloid angiopathy (CAA) after up to 10 years follow-up in the Vantaa 85+ population. METHODS: Study population included 149 participants aged ≥85 years, without dementia at baseline, and with available clinical and autopsy data...
January 25, 2018: Journal of Internal Medicine
Marcus Fändrich, Sofie Nyström, K Peter R Nilsson, Anja Böckmann, Harry LeVine, Per Hammarström
The accumulation of misfolded proteins (MP), both unique and common, for different diseases is central for many chronic degenerative diseases. In certain patients MP accumulation is systemic (e.g. TTR amyloid) and in others this is localized to a specific cell type (e.g. Alzheimer's disease). In neurodegenerative diseases, NDs, it is noticeable that the accumulation of MP progressively spreads throughout the nervous system. Our main hypothesis of this article is that MPs are not only markers but also active carriers of pathogenicity...
January 23, 2018: Journal of Internal Medicine
Emil Hagström
We thank Dr Mazokopakis [1] for the historical notions on the relation between feeling depressed and cardiovascular disease. It is indeed fascinating that already 2,000 years ago, the link between sorrow (and perhaps depression) and disease had been observed. The past knowledge on the complex relation between low socioeconomic status, depression/being sorrow and heart disease is still, 2,000 years later, a growing contemporary problem[2]. Being sorrow could, besides being interpreted as part of a longer standing depression, also reflect a state of more acute emotional stress, such as after the death of a beloved one, sometimes observed causing Takotsubo cardiomyopathy[3]...
January 21, 2018: Journal of Internal Medicine
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