journal
MENU ▼
Read by QxMD icon Read
search

Journal of Internal Medicine

journal
https://www.readbyqxmd.com/read/28649750/vasopressin-physiology-assessment-and-osmosentation
#1
Lise Bankir, Daniel G Bichet, Nils G Morgenthaler
Vasopressin (AVP) plays a major role in the regulation of water and sodium homeostasis by its antidiuretic action on the kidney, mediated by V2 receptors. AVP secretion is stimulated by a rise in plasma osmolality, a decline in blood volume, or stress. V1a receptors are expressed in vascular smooth muscle cells but the role of vasopressin in blood pressure regulation is still a matter of debate. AVP may also play a role in some metabolic pathways, including gluconeogenesis, through its action on V1a receptors expressed in the liver...
June 25, 2017: Journal of Internal Medicine
https://www.readbyqxmd.com/read/28646607/more-pieces-of-the-fructose-puzzle
#2
Kimber L Stanhope
The involvement of fructose in cardiometabolic health continues to be a controversial topic. In just the last twelve months, there have been at least eight reviews published on the subject. Four of these reviews detailed mechanisms by which dietary fructose may have direct deleterious on effects on human health [1-4]. This article is protected by copyright. All rights reserved.
June 24, 2017: Journal of Internal Medicine
https://www.readbyqxmd.com/read/28643889/reply-to-letter-to-the-editor-regarding-the-article-should-we-treat-severe-vasovagal-syncope-with-a-pacemaker
#3
LETTER
Richard Sutton
First, I wish to thank the Southampton group for their interest in and compliments about the review (1). Second, I congratulate them on their approach to pacing in vasovagal syncope, using the leadless pacemaker. Their desire to limit, as far as possible, the complications of pacing in young vasovagal patients is praiseworthy. In my experience (unpublished) of around 30 patients of <40 years paced for vasovagal syncope, complications have been more frequent than in the older vasovagal patient and for pacing in more conventional indications...
June 23, 2017: Journal of Internal Medicine
https://www.readbyqxmd.com/read/28643850/the-role-of-leadless-single-chamber-pacemakers-in-the-treatment-of-vasovagal-syncope
#4
LETTER
Benedict M Wiles, Paul R Roberts
We read with great interest the excellent review by R. Sutton 'Should we treat severe vasovagal syncope with a pacemaker?' We agree that permanent cardiac pacing is only suitable for a tiny minority of patients with vasovagal syncope. At our institution we have a policy of avoiding pacing wherever possible in young patients due to the long term issues related to transvenous devices. However we do not necessarily agree that there is an acceptance that pacing for vasovagal syncope must be dual chamber, especially since the emergence of single chamber leadless pacemaker systems...
June 23, 2017: Journal of Internal Medicine
https://www.readbyqxmd.com/read/28635127/cardiovascular-risk-score-is-linked-to-subcutaneous-adipocyte-size-and-lipid-metabolism
#5
Mikael Rydén, Peter Arner
OBJECTIVE: Although white adipose tissue mass and distribution correlates with cardiovascular disease, the fat cell-specific perturbations underlying this association are not known. We determined the relationship between adipocyte size and lipid metabolism with cardiovascular risk. DESIGN/SUBJECTS: Adipocyte size as well as spontaneous (basal) and hormone-stimulated effects on adipocyte lipid metabolism (lipolysis and lipogenesis) were investigated in abdominal subcutaneous adipose tissue of 304 men and 775 women...
June 21, 2017: Journal of Internal Medicine
https://www.readbyqxmd.com/read/28631441/genetic-landscape-and-deregulated-pathways-in-b-cell-lymphoid-malignancies
#6
R Rosenquist, S Beà, M-Q Du, B Nadel, Q Pan-Hammarström
With the introduction of next-generation sequencing, the genetic landscape of the complex group of B-cell lymphoid malignancies has rapidly been unravelled in recent years. This has provided important information about recurrent genetic events and identified key pathways deregulated in each lymphoma subtype. In parallel, there has been intense search and development of novel types of targeted therapy that 'hit' central mechanisms in lymphoma pathobiology, such as BTK, PI3K or BCL2 inhibitors. In this review, we will outline the current view of the genetic landscape of selected entities: follicular lymphoma, diffuse large B-cell lymphoma, mantle cell lymphoma, chronic lymphocytic leukaemia and marginal zone lymphoma...
June 20, 2017: Journal of Internal Medicine
https://www.readbyqxmd.com/read/28621880/response-to-letter-to-the-editor-regarding-the-article-the-seasonal-importance-of-serum-25-hydroxyvitamin-d-for-bone-mineral-density-in-older-women
#7
LETTER
Karl Michaëlsson, Håkan Melhus
We thank dr Sugiyama for his thoughts regarding our publication [1]. These comments mainly deal with differences in physical activity as an underlying explanation for our findings and a null effect on BMD with vitamin D supplementation in meta-analyses of RCTs. We agree, that a more accurate definition of true vitamin D deficiency is needed. This article is protected by copyright. All rights reserved.
June 16, 2017: Journal of Internal Medicine
https://www.readbyqxmd.com/read/28574621/prospects-for-induction-of-cd8-t-cell-mediated-immunity-to-zika-virus-infection-by-yellow-fever-virus-yfv-vaccination
#8
Kim Blom, John Tyler Sandberg, Karin Loré, Hans-Gustaf Ljunggren
The Zika virus epidemic represents an unprecedented health crisis affecting significant parts of the world (1) . On February 1(st) 2016, the WHO declared the reported clusters of Zika-virus induced microcephaly and other neurological disorders a Public Health Emergency of International Concern (PHEIC). The epidemic is currently ongoing in Latin America and the Caribbean, with impacts of the infection already seen in large populations of Brazil, Colombia, Mexico, Peru and beyond. No specific treatment or vaccine is available, although several candidates are under development (2) ...
June 2, 2017: Journal of Internal Medicine
https://www.readbyqxmd.com/read/28564488/noninvasive-beat-to-beat-finger-arterial-pressure-monitoring-during-orthostasis-a-comprehensive-review-of-normal-and-abnormal-responses-at-different-ages
#9
REVIEW
V K van Wijnen, C Finucane, M P M Harms, H Nolan, R L Freeman, B E Westerhof, R A Kenny, J C Ter Maaten, W Wieling
Over the past 30 years, noninvasive beat-to-beat blood pressure (BP) monitoring has provided great insight into cardiovascular autonomic regulation during standing. Although traditional sphygmomanometric measurement of BP may be sufficient for detection of sustained orthostatic hypotension, it fails to capture the complexity of the underlying dynamic BP and heart rate responses. With the emerging use of noninvasive beat-to-beat BP monitoring for the assessment of orthostatic BP control in clinical and population studies, various definitions for abnormal orthostatic BP patterns have been used...
May 31, 2017: Journal of Internal Medicine
https://www.readbyqxmd.com/read/28561269/combined-impact-of-healthy-lifestyle-factors-on-lifespan-two-prospective-cohorts
#10
S C Larsson, J Kaluza, A Wolk
BACKGROUND: The impact of multiple healthy lifestyle factors on survival time is unclear. OBJECTIVE: The aim of this study was to examine differences in survival time associated with a healthy lifestyle vs a less healthy lifestyle. METHODS: This study consisted of 33 454 men (Cohort of Swedish Men) and 30 639 women (Swedish Mammography Cohort) aged 45 to 83 years and free of cancer and cardiovascular disease at baseline. The healthy lifestyle factors included: (1) nonsmoking; (2) physical activity at least 150 min/week; (3) alcohol consumption of 0-14 drinks/week; (4) and healthy diet defined as a modified Dietary Approaches to Stop Hypertension Diet score above the median...
May 31, 2017: Journal of Internal Medicine
https://www.readbyqxmd.com/read/28548281/adverse-effects-of-fructose-on-cardiometabolic-risk-factors-and-hepatic-lipid-metabolism-in-subjects-with-abdominal-obesity
#11
Marja-Riitta Taskinen, Sanni Söderlund, Leonie H Bogl, Antti Hakkarainen, Niina Matikainen, Kirsi H Pietiläinen, Sari Räsänen, Nina Lundbom, Elias Björnson, Björn Eliasson, Rosellina M Mancina, Stefano Romeo, Natalie Alméras, Giuseppe Della Pepa, Claudia Vetrani, Anna Prinster, Giovanni Annuzzi, Angela Rivellese, Jean-Pierre Després, Jan Borén
BACKGROUND: Overconsumption of dietary sugars, fructose in particular, is linked to cardiovascular risk factors such as type 2 diabetes, obesity, dyslipidemia, and non-alcoholic fatty liver disease. However, clinical studies have to date not clarified whether these adverse cardiometabolic effects are induced directly by dietary sugars, or if they are secondary to weight gain. OBJECTIVES: To assess the effects of fructose (75 g/day), served with their habitual diet over 12 weeks, on liver fat content and other cardiometabolic risk factors in a large cohort (n=71) of abdominally obese men...
May 26, 2017: Journal of Internal Medicine
https://www.readbyqxmd.com/read/28547823/asthma-other-atopic-conditions-and-risk-of-infections-in-105-519-general-population-never-and-ever-smokers
#12
Jens Helby, Børge Grønne Nordestgaard, Thomas Benfield, Stig Egil Bojesen
BACKGROUND: Individuals with atopic conditions may have increased susceptibility to infections outside the organs directly affected by their atopic condition. OBJECTIVE: We tested the hypothesis that atopic conditions overall, and stratified by smoking history, are associated with increased risk of hospitalization for infections. METHODS: We collected information on smoking history and self-reported atopic conditions from 105,519 individuals from the general population and followed them for up to 23 years for infectious disease hospitalizations and deaths...
May 26, 2017: Journal of Internal Medicine
https://www.readbyqxmd.com/read/28547815/balancing-the-autonomic-nervous-system-to-reduce-inflammation-in-rheumatoid-arthritis
#13
F A Koopman, M A van Maanen, M J Vervoordeldonk, P P Tak
Imbalance in the autonomic nervous system (ANS) has been observed in many established chronic autoimmune diseases, including rheumatoid arthritis (RA), which is a prototypic immune-mediated inflammatory disease (IMID). We recently discovered that autonomic dysfunction precedes and predicts arthritis development in subjects at risk of developing seropositive RA. In addition, RA patients with relatively high vagus nerve tone (higher parasympathetic parameters, measured by heart rate variability) respond better to antirheumatic therapies...
May 26, 2017: Journal of Internal Medicine
https://www.readbyqxmd.com/read/28524624/pulmonary-arterial-hypertension-progress-in-understanding-the-disease-and-prioritizing-strategies-for-drug-development
#14
REVIEW
P Ghataorhe, C J Rhodes, L Harbaum, M Attard, J Wharton, M R Wilkins
Pulmonary arterial hypertension (PAH), at one time a largely overlooked disease, is now the subject of intense study in many academic and biotech groups. The availability of new treatments has increased awareness of the condition. This in turn has driven a change in the demographics of PAH, with an increase in the mean age at diagnosis. The diagnosis of PAH in more elderly patients has highlighted the need for careful phenotyping of patients and for further studies to understand how best to manage pulmonary hypertension associated with, for example, left heart disease...
May 19, 2017: Journal of Internal Medicine
https://www.readbyqxmd.com/read/28514081/weight-loss-and-improved-metabolic-outcomes-amongst-rural-african-american-women-in-the-deep-south-six-month-outcomes-from-a-community-based-randomized-trial
#15
J D Ard, T L Carson, J M Shikany, Y Li, C M Hardy, J C Robinson, A G Williams, M L Baskin
BACKGROUND: Obesity is highly prevalent in African American women, especially those in the rural southern USA, resulting in persistent health disparities. OBJECTIVE: To test the effectiveness of an evidence-based behavioural weight loss intervention delivered by community health advisors to African American women in the rural south. DESIGN AND METHODS: Overweight or obese African American women (30-70 years) from eight counties in Mississippi and Alabama participated in a 24-month randomized controlled trial of an evidence-based behavioural weight loss programme augmented with community strategies to support healthy lifestyles (Weight Loss Plus, N = 154) compared to the weight loss programme alone (Weight Loss Only, N = 255)...
May 17, 2017: Journal of Internal Medicine
https://www.readbyqxmd.com/read/28503820/the-p2x7-receptor-nlrp3-inflammasome-complex-predicts-the-development-of-non-hodgkin-s-lymphoma-in-sjogren-s-syndrome-a-prospective-observational-single-centre-study
#16
C Baldini, E Santini, C Rossi, V Donati, A Solini
BACKGROUND: P2X7 receptor (P2X7R), trigger of acute inflammatory responses via the NLRP3 inflammasome, is hyperfunctioning in patients with Sjögren's syndrome (SS), where it stimulates IL-18 production. Some patients with SS develop a mucosa-associated lymphoid tissue non-Hodgkin's lymphoma (MALT-NHL). OBJECTIVES: To prospectively evaluate the involvement and the putative prognostic role of this inflammatory pathway in the development of MALT-NHL. METHODS: A total of 147 women with SS have been prospectively followed for a mean of 52 months, relating the expression and function of the P2X7R-inflammasome axis in salivary glands and circulating lymphomonocytes to the prognosis and the degree of the disease...
May 15, 2017: Journal of Internal Medicine
https://www.readbyqxmd.com/read/28494128/alcohol-consumption-cigarette-smoking-and-incidence-of-aortic-valve-stenosis
#17
S C Larsson, A Wolk, M Bäck
BACKGROUND: Alcohol consumption and cigarette smoking are modifiable lifestyle factors with important impact on public health. It is unclear whether these factors influence the risk of aortic valve stenosis (AVS). OBJECTIVE: To investigate the associations of alcohol consumption and smoking, including smoking intensity and time since cessation, with AVS incidence in two prospective cohorts. METHODS: This analysis was based on data from the Swedish Mammography Cohort and the Cohort of Swedish Men, comprising 69 365 adults without cardiovascular disease at baseline...
May 11, 2017: Journal of Internal Medicine
https://www.readbyqxmd.com/read/28480532/hydrochlorothiazide-use-is-strongly-associated-with-risk-of-lip-cancer
#18
A Pottegård, J Hallas, M Olesen, M T Svendsen, L A Habel, G D Friedman, S Friis
BACKGROUND: The diuretic hydrochlorothiazide is amongst the most frequently prescribed drugs in the United States and Western Europe, but there is suggestive evidence that hydrochlorothiazide use increases the risk of lip cancer. OBJECTIVES: To study the association between use of hydrochlorothiazide and squamous cell carcinoma of the lip. METHODS: We conducted a case-control study using Danish nationwide registry data. From the Cancer Registry (2004-2012), we identified 633 case patients with squamous cell carcinoma (SCC) of the lip and matched them to 63 067 population controls using a risk-set sampling strategy...
May 8, 2017: Journal of Internal Medicine
https://www.readbyqxmd.com/read/28480507/initiation-of-anticoagulation-in-atrial-fibrillation-which-factors-are-associated-with-choice-of-anticoagulant
#19
A Gundlund, L Staerk, E L Fosbøl, K Gadsbøll, C Sindet-Pedersen, A N Bonde, G H Gislason, J B Olesen
BACKGROUND: The use of non-vitamin K antagonist oral anticoagulants (NOACs) for stroke prophylaxis in atrial fibrillation (AF) is increasing rapidly. We compared characteristics of AF patients initiated on NOACs versus vitamin K antagonists (VKAs). METHODS: Using Danish nationwide registry data, we identified AF patients initiating either a VKA or a NOAC from 22 August 2011 until 30 September 2016. We compared patient characteristics including age, gender, comorbidities, concomitant pharmacotherapy and CHA2 DS2 -VASc and HAS-BLED scores in patients initiated on a VKA, dabigatran, rivaroxaban or apixaban...
May 8, 2017: Journal of Internal Medicine
https://www.readbyqxmd.com/read/28470872/how-long-do-centenarians-survive-life-expectancy-and-maximum-lifespan
#20
K Modig, T Andersson, J Vaupel, R Rau, A Ahlbom
OBJECTIVES: The purpose of this study was to explore the pattern of mortality above the age of 100 years. In particular, we aimed to examine whether Scandinavian data support the theory that mortality reaches a plateau at particularly old ages. Whether the maximum length of life increases with time was also investigated. METHODS: The analyses were based on individual level data on all Swedish and Danish centenarians born from 1870 to 1901; in total 3006 men and 10 963 women were included...
May 4, 2017: Journal of Internal Medicine
journal
journal
30078
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"