Ana Silva, Daniel Luís, Susana Santos, Joana Silva, Ana Soraia Mendo, Lidia Coito, Telma F S Silva, Maria Fatima C Guedes da Silva, Luísa M D R S Martins, Armando J L Pombeiro, Pedro M Borralho, Cecília M P Rodrigues, Maria Guadalupe Cabral, Paula A Videira, Carolino Monteiro, Alexandra R Fernandes
BACKGROUND: The discovery of cisplatin's antitumor activity led to a great interest in the potential application of coordination compounds as chemotherapeutic agents. It is essential to identify new compounds that selectively inhibit tumor proliferation, evading secondary effects and resistance associated with chemotherapeutics. METHODS: The in vitro antiproliferative potential of an organotin(IV) compound was evaluated using colorectal and hepatocellular carcinoma, mammary gland adenocarcinoma cell lines, and human fibroblasts...
2013: Drug Metabolism and Drug Interactions