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Phytotherapy Research: PTR

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https://www.readbyqxmd.com/read/30427093/randomized-double-blind-placebo-controlled-phase-ii-trial-of-nanocurcumin-in-prostate-cancer-patients-undergoing-radiotherapy
#1
Afshin Saadipoor, Abolfazl Razzaghdoust, Nasser Simforoosh, Arash Mahdavi, Mohsen Bakhshandeh, Maryam Moghadam, Hamid Abdollahi, Bahram Mofid
Clinical potential of curcumin in radiotherapy (RT) setting is outstanding and of high interest. The main purpose of this randomized controlled trial (RCT) was to assess the beneficial role of nanocurcumin to prevent and/or mitigate radiation-induced proctitis in prostate cancer patients undergoing RT. In this parallel-group study, 64 eligible patients with prostate cancer were randomized to receive either oral nanocurcumin (120 mg/day) or placebo 3 days before and during the RT course. Acute toxicities including proctitis and cystitis were assessed weekly during the treatment and once thereafter using CTCAE v...
November 14, 2018: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/30421555/herbal-medicine-in-oral-lichen-planus
#2
REVIEW
Atefeh Ghahremanlo, Nadia Boroumand, Kiarash Ghazvini, Seyed Isaac Hashemy
Oral lichen planus (OLP) is a common chronic inflammatory and T cell-mediated autoimmune disease in which the oral mucosa, tongue, and gingiva are involved. Different treatments have been suggested to reduce the symptoms of this disease. Currently, a common treatment for OLP is the use of corticosteroids as the gold standard, although they have considerable side effects. The chronicity of the disease needs the long-term use of these drugs with ensuing side effects. Therefore, various studies have been done to find an alternative and effective treatment...
November 12, 2018: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/30421466/isobavachalcone-attenuates-myotube-atrophy-induced-by-tnf-%C3%AE-through-muscle-atrophy-f-box-signaling-and-the-nuclear-factor-erythroid-2-related-factor-2-cascade
#3
Jinyoung Hur, Mina Kim, Sang Yoon Choi, YoungJin Jang, Tae Youl Ha
Skeletal muscle atrophy is a condition characterized by damaged muscle fibers and reduced numbers of muscle cells due to various causes. Muscle atrophy is associated with chronic diseases, such as heart failure, diabetes, and aging-related diseases. Isobavachalcone (IBC) is a flavonoid found in various foods and natural products, and studies have investigated its diverse effects, including its neuroprotective and anticancer effects. However, no studies have evaluated the effects of IBC on muscle atrophy. Thus, in this study, we assessed the effects of IBC on prevention of muscle atrophy...
November 12, 2018: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/30421463/effect-of-puerarin-on-melanogenesis-in-human-melanocytes-and-vitiligo-mouse-models-and-the-underlying-mechanism
#4
Xiaoxia Ding, Enci Mei, Murong Hu, Chaofeng Zhou, Xiaobin Li, Lei Cai, Zhiming Li
Puerarin is the major bioactive ingredient derived from the root of the Pueraria lobata (Willd.), and its antioxidative stress effects have been demonstrated in several previous studies. Moreover, Puerarin can upregulate melanin synthesis and microphthalmia-associated transcription factor (MITF) transcription by increasing cAMP level of intracellular cyclic adenosine monophosphate. Vitiligo is an acquired cutaneous disorder of pigmentation, and the pathogenesis has remained elusive. Current treatment modalities are directed towards achieving repigmentation...
November 12, 2018: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/30421460/calycosin-attenuates-mptp-induced-parkinson-s-disease-by-suppressing-the-activation-of-tlr-nf-%C3%AE%C2%BAb-and-mapk-pathways
#5
Jing Yang, Mengmeng Jia, Xiaojian Zhang, Peile Wang
Parkinson is the second common neurodegenerative disease. The characteristics of Parkinson's disease (PD) are the dopamin neurons loss caused by neuroinflammation responses. C alycosin, an isoflavone phytoestrogen isolated from Astragalus membranaceus, has multiple pharmacological activities, such as anti-inflammation, anti-tumor, and neuroprotective effects. However, it is unknown whether calycosin can mitigate PD symptoms. This study aims to explore whether calycosin can alleviate PD symptoms and the underlying mechanisms...
November 12, 2018: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/30417583/enzymes-inhibitors-from-natural-sources-with-antidiabetic-activity-a-review
#6
REVIEW
Fiaz Alam, Zainab Shafique, Sayyeda Tayyeba Amjad, Mohammad Hassham Hassan Bin Asad
Natural products have been extensively investigated for antidiabetic therapy. Many of the natural products have direct or indirect effect in diabetes pathways as enzyme inhibitors. The most involved mechanisms are inhibition of intestinal alpha-glucosidase and alpha-amylase, lens aldose reductase, oxidative stress protection, inhibition of formation of advanced glycation end products, inhibition of aldose reductase, lowering plasma glucose levels, altering enzyme activity of hexokinases and glucose-6-phosphate, synthesizing and releasing of insulin, postprandial hyperglycemia inhibition, stimulation of GLUT-4, decreasing activity of G6P, lowering the level of skeletal hexokinases, etc...
November 11, 2018: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/30417444/the-triptolide-induced-apoptosis-of-osteoclast-precursor-by-degradation-of-ciap2-and-treatment-of-rheumatoid-arthritis-of-tnf-transgenic-mice
#7
Shengli Wang, Zhigang Liu, Jingchun Wang, Yifei Wang, Jianhua Liu, Xinying Ji, Xinchun Wang
This study aims to discuss the effect of triptolide (TPL) on rheumatoid arthritis (RA) and the mechanism related to osteoclast precursor (OCP) and osteoclast (OC). TNF-transgenic RA mice were treated with different doses of TPL by gavage. After the administration was finished, the curative effects were evaluated and compared, and the OCP apoptosis rates, the OC number, and the OC differentiation ability in vitro were detected. Finally, splenocytes of wild-type mice were cultured in vitro and induced to differentiate into OCP, and the cell apoptosis rate, cIAP2, and apoptotic effectors expression level were detected after cIAP2 overexpression and TPL administration...
November 11, 2018: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/30402990/the-effects-of-curcumin-containing-supplements-on-biomarkers-of-inflammation-and-oxidative-stress-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#8
REVIEW
Reza Tabrizi, Sina Vakili, Maryam Akbari, Naghmeh Mirhosseini, Kamran B Lankarani, Maryam Rahimi, Moein Mobini, Sadegh Jafarnejad, Zahra Vahedpoor, Zatollah Asemi
Besides other benefits, curcumin is getting more recognized for its antioxidant and anti-inflammatory properties, highlighting the importance of curcumin application for chronic disease prevention. This systematic review and meta-analysis of randomized controlled trials (RCTs) was conducted to assess the influence of curcumin-containing supplements on biomarkers of inflammation and oxidative stress. MEDLINE, EMBASE, Web of Science, and Cochrane Central Register of Controlled Trials were searched till January 2018 for eligible studies...
November 7, 2018: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/30402931/chemo-preventive-and-therapeutic-effect-of-the-dietary-flavonoid-kaempferol-a-comprehensive-review
#9
REVIEW
Muhammad Imran, Abdur Rauf, Zafar Ali Shah, Farhan Saeed, Ali Imran, Muhammad Umair Arshad, Bashir Ahmad, Sami Bawazeer, Muhammad Atif, Dennis G Peters, Mohammad S Mubarak
Kaempferol, a natural flavonoid present in several plants, possesses a wide range of therapeutic properties such as antioxidant, anticancer, and anti-inflammatory. It has a significant role in reducing cancer and can act as a therapeutic agent in the treatment of diseases and ailments such as diabetes, obesity, cardiovascular diseases, oxidative stress, asthma, and microbial contamination disorders. Kaempferol acts through different mechanisms: It induces apoptosis (HeLa cervical cancer cells), decreases cell viability (G2/M phase), downregulates phosphoinositide 3-kinase (PI3K)/AKT (protein kinase B) and human T-cell leukemia/lymphoma virus-I (HTLV-I) signaling pathways, suppresses protein expression of epithelial-mesenchymal transition (EMT)-related markers including N-cadherin, E-cadherin, Slug, and Snail, and metastasis-related markers such as matrix metallopeptidase 2 (MMP-2)...
November 7, 2018: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/30402951/berberine-alleviates-oxidized-low-density-lipoprotein-induced-macrophage-activation-by-downregulating-galectin-3-via-the-nf-%C3%AE%C2%BAb-and-ampk-signaling-pathways
#10
ChongZhe Pei, Yi Zhang, Ping Wang, BeiJian Zhang, Lu Fang, Bo Liu, Shu Meng
Macrophage activation plays a central role in neoatherosclerosis and in-stent restenosis after percutaneous coronary intervention (PCI). Galectin-3, mainly expressed on macrophages, is an important regulator of inflammation. This study aimed to investigate the effects of berberine (BBR) on oxidized low-density lipoprotein (ox-LDL)-induced macrophage activation and galectin-3 expression and their underlying mechanisms. THP-1-derived macrophages were pretreated with BBR prior to stimulation with ox-LDL. Galectin-3 expression was measured by real-time PCR, Western blotting, and confocal microscopy...
November 6, 2018: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/30402894/transport-of-salvianolic-acid-b-via-the-human-organic-anion-transporter-1b1-in-the-liver
#11
Li Cao, Jian Zhou, Jinhua Wen
Salvianolic acid B (SAB) has a high concentration in the liver, but the mechanism of its distribution in the liver is unclear. The aim of this study was to investigate the mechanisms of hepatic uptake of SAB. In this study, we first explored the uptake features of SAB in HepG2 cells and the effect of rifampicin on uptake. Then, we explored the effects of SAB on the uptake of pitavastatin in HepG2 cells. Finally, we established an HEK239T-OATP1B1 cell model to confirm whether OATP1B1 mediated the transport of SAB...
November 6, 2018: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/30375074/histone-acetylation-increases-in-response-to-ferulic-gallic-and-sinapic-acids-acting-synergistically-in-vitro-to-inhibit-candida-albicans-yeast-to-hyphae-transition
#12
Cristiane Rodrigues S Câmara, Qinyin Shi, Matthew Pedersen, Richard Zbasnik, Kenneth W Nickerson, Vicki Schlegel
Novel treatments are needed to prevent candidiasis/candidemia infection due to the emergence of Candida species resistant to current antifungals. Considering the yeast-to-hyphae switch is a critical factor to Candida albicans virulence, phenols common in plant sources have been reported to demonstrating their ability to prevent dimorphism. Therefore, phenols present in many agricultural waste stress (ferulic (FA) and gallic (GA) acid) were initially screened in isolation for their yeast-to-hyphae inhibitory properties at times 3, 6, and 24 hr...
October 29, 2018: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/30375066/sida-tuberculata-extract-reduces-the-nociceptive-response-by-chemical-noxious-stimuli-in-mice-implications-for-mechanism-of-action-relation-to-chemical-composition-and-molecular-docking
#13
Hemerson S da Rosa, Igor S Coelho, Morgana Duarte da Silva, Mariana S Fernandes, Pablo Ricardo Bertelli, Luciane Minetto, Sidnei Moura, Fávero de Paula, Adair R Santos, Andreas S L Mendez, Vanderlei Folmer
No abstract text is available yet for this article.
October 29, 2018: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/30375049/-isobicyclogermacrenal-and-spathulenol-from-aristolochia-yunnanensis-alleviate-cardiac-fibrosis-by-inhibiting-transforming-growth-factor-%C3%AE-small-mother-against-decapentaplegic-signaling-pathway
#14
Lan-Lan Lou, Wei Li, Bin-Hua Zhou, Lin Chen, Han-Zhuang Weng, Yi-Hong Zou, Gui-Hua Tang, Xian-Zhang Bu, Sheng Yin
Cardiac fibrosis contributes to both systolic and diastolic dysfunction in many cardiac pathophysiologic conditions. Antifibrotic therapies are likely to be a crucial strategy in curbing many fibrosis-related cardiac diseases. In our previous study, an ethyl acetate extract of a traditional Chinese medicine Aristolochia yunnanensis Franch. was found to have a therapeutic effect on myocardial fibrosis in vitro and in vivo. However, the exact chemicals and their mechanisms responsible for the activity of the crude extract have not been illustrated yet...
October 29, 2018: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/30375037/radix-paeoniae-alba-increases-serum-estrogen-level-and-up-regulates-estrogen-receptor-expression-in-uterus-and-vagina-of-immature-ovariectomized-mice
#15
Ying Xu, Xin Li, Ting Chen, Ya-Kun Qu, Hong-Xia Zheng, Zi-Jia Zhang, Yuan Zhao, Na Lin
Radix Paeoniae Alba (RPA) is widely used in clinical treatment for gynecological diseases, particularly abnormal menstruation, menstrual pain, and breast tenderness; however, no scientific evidence base links RPA to estrogen replacement therapy. In this study, we characterize estrogenic activity of RPA using immature and ovariectomized (OVX) mice together with in vitro studies focus on estrogen receptor (ER) pathway for molecular mechanism. RPA treatments demonstrated significant estrogenic activity, as indicated by promoting the development of uterus and vagina in immature mice, reversing the atrophy of uterus and vagina in OVX mice, up-regulating the expressions of ERα and ERβ at protein and mRNA level in reproductive tissues...
October 29, 2018: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/30370629/effect-of-garlic-supplementation-on-serum-c-reactive-protein-level-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#16
REVIEW
Mohsen Taghizadeh, Zahra Hamedifard, Sadegh Jafarnejad
The present study was designed to systematically review randomized controlled trials (RCTs) that report on the effects of garlic supplementation on serum C-reactive protein (CRP) levels. We conducted a literature search of Scopus, PubMed, Cochrane Library, and Google Scholar up to January 2018. Weighted mean differences (WMD) were estimated for net change in serum CRP. Subgroup analyses were also performed by duration of study, dose of supplementation, baseline CRP level, and the quality of studies. From 438 articles found and screened in our initial search, nine RCTs with the sum of total sample size of 363 were included in the meta-analysis...
October 29, 2018: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/30357956/plant-derived-alkaloid-sinomenine-potentiates-glucocorticoid-pharmacodynamics-in-mitogen-activated-human-peripheral-blood-mononuclear-cells-by-regulating-the-translocation-of-glucocorticoid-receptor
#17
Wencheng Xu, Xiaoqin Wang, Yuanchao Tu, Hiroshi Masaki, Sachiko Tanaka, Kenji Onda, Kentaro Sugiyama, Haruki Yamada, Toshihiko Hirano
Sinomenine has been used as an antirheumatic drug in China. Glucocorticoid combined with sinomenine could be an alternative therapeutic approach. In this study, we evaluated the sinomenine potential effect on glucocorticoid pharmacodynamics in vitro using a human peripheral blood mononuclear cell (PBMC) culture system. We also disclosed the possible action mechanism of sinomenine with a focus on P-glycoprotein function and glucocorticoid receptor (GR) translocation into nucleus. The median (range) of methylprednisolone IC50 values against the PBMC proliferation was 3...
October 25, 2018: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/30353592/immunomodulatory-effect-of-cynara-scolymus-artichoke-in-rats
#18
Isis Machado Hueza, André Tadeu Gotardo, Maria Izabel da Silva Mattos, Silvana Lima Górniak
Cynara scolymus is a plant used both as food as well as medicinal plant worldwide. Cynarin is one of the main active principles of the plant, and it is also present in species such as Echinacea purpurae, which is known to have immunomodulatory activity. Thus, the objective of this study is to evaluate the immune effects of C. scolymus in rats. Rats were treated with 1.0-, 2.0-, or 4.0-g/kg body weight of C. scolymus extract for 28 days. Haemogram, serum biochemistry, lymphoid organs weight, and their cell phenotypes were evaluated...
October 24, 2018: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/30346086/phytochemical-information-and-pharmacological-activities-of-okra-abelmoschus-esculentus-a-literature-based-review
#19
REVIEW
Muhammad Torequl Islam
This review aimed at summarizing phytochemical reports and biological activities of Abelmoschus esculentus L. from the database sources. For this, an up-to-date search was made in the PubMed, Science Direct, MedLine, Scopus, and Google Scholar. The findings suggest that A. esculentus contains various nutrients and important phytochemicals. It possesses a number of important biological activities, including antioxidant, anti-inflammatory and immunomodulatory, antibacterial, anticancer, antidiabetic, organ protective, and neuropharmacological activities...
October 22, 2018: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/30346082/the-antitumour-growth-and-antiangiogenesis-effects-of-xanthatin-in-murine-glioma-dynamically-evaluated-by-dynamic-contrast-enhanced-magnetic-resonance-imaging
#20
Si-Xing Bi, Xiao-Hu Li, Chuan-Sheng Wei, Hui-Hui Xiang, Yu-Xian Shen, Yong-Qiang Yu
To investigate the suppressive effects of xanthatin on glioma growth in a nude mouse xenograft model and rat orthotopic implantation model using magnetic resonance imaging (MRI) to dynamically monitor the antitumour growth and antiangiogenesis effects of xanthatin. The nude mouse xenograft tumour model and rat orthotopic implantation model were established to observe the antitumour effects of xanthatin in vivo. In the rat orthotopic implanted tumour model, MRI scanning was used to dynamically monitor the antitumour growth effect and evaluate the antiangiogenesis effect of xanthatin...
October 22, 2018: Phytotherapy Research: PTR
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