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Phytotherapy Research: PTR

Marina Pereira Rocha, Priscilla Rodrigues Valadares Campana, Denise de Oliveira Scoaris, Vera Lúcia de Almeida, Júlio César Dias Lopes, Andréia Fonseca Silva, Luc Pieters, Cláudia Gontijo Silva
Species of Aspidosperma are traditionally used to treat malaria, leishmaniasis, microbial, and inflammatory diseases. Aspidosperma subincanum Mart. known as "guatambu" is used in Brazilian traditional medicine to treat diabetes, hypercholesterolemia, and digestive diseases. Its tonic properties have been employed by the indigenous populations to stimulate the circulatory and genitourinary tracts and to improve respiratory function as well as to relieve spasms and to reduce fever. The species is known to contain antitumoural and antimalarial indole alkaloids...
July 12, 2018: Phytotherapy Research: PTR
Hamideh Kazemirad, Hamid Reza Kazerani
Pomegranate juice (Pg) has demonstrated cardiovascular beneficial effects. The current research intends to investigate the roles of nitric oxide (NO) and antioxidants in Pg-induced cardioprotection against ischemia and reperfusion (I/R). Isolated hearts from anesthetized rats were subjected to 30-min global ischemia followed by 120-min reperfusion. The hearts in the test groups were treated with Pg, NG -nitro-L-arginine methyl ester (L-NAME) or both throughout the experiment. In Pg group, left ventricular developed pressure, rate of rise in left ventricular pressure (dp/dt max), and rate pressure product were 83%, 55%, and 127%, respectively, higher than those of the control group (p < 0...
July 12, 2018: Phytotherapy Research: PTR
Elysiane S da Silva, Bruno G Oliveira, Ana Claudia H Pereira, Elisângela F Pimentel, John M Pezzuto, Dominik Lenz, Tamara P Kondratyuk, Tadeu U Andrade, Marcio Fronza, Rodrigo Scherer, June F Maia, Wanderson Romão, Flávio de L Alves, José A Ventura, Denise C Endringer
Toranja 'Burarama', Citrus maxima (Burm.) Merr. (Citrus grandis), is a new citrus discovered in the State of Espírito Santo, Brazil. As several varieties of citrus are known to possess antioxidant and cancer chemopreventive properties, the aim of the study was to evaluate in vitro if this Toranja possess these properties. The antioxidant activity, the potential to induce quinone reductase 1, and the influence on cell viability were measured. ESI(-)FT-ICR MS analysis was also performed and identified flavonoids, coumarins, and fatty acids in the extract...
July 12, 2018: Phytotherapy Research: PTR
Wan Nurfarahin Wan Osman, Suhaila Mohamed
The antifatigue properties of Morinda elliptica (ME) leaf were compared with Morinda citrifolia (MC) leaf extracts. Sixty Balb/C mice were administered (N = 10): control water, standardized green tea extract (positive control 200 mg/kg body weight [BW]), either 200 or 400 mg MC/kg BW, or either 200 or 400 mg ME/kg BW). The mice performances, biochemical, and mRNA expressions were evaluated. After 6 weeks, the weight-loaded swimming time to exhaustion in the mice consuming 400 mg MC/kg, were almost five times longer than the control mice...
July 11, 2018: Phytotherapy Research: PTR
Kyung Hee Jung, Marufa Rumman, Honghua Yan, Min Ji Cheon, Jin Gyu Choi, Xing Jin, Sunghouk Park, Myung Sook Oh, Soon-Sun Hong
In cancer treatment, herbal medicines may be a good choice because of the reduced risk of adverse side effects. Artemisia capillaris has been recognized as a promising candidate due to its hepatoprotective effects. Herein, we investigated whether A. capillaris-derived fraction (ACE-63) could inhibit the progression of hepatocellular carcinoma (HCC) and its underlying mechanism. In this study, ACE-63 effectively inhibited the growth and proliferation of HCC cells. ACE-63 induced apoptosis, as observed using Terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) staining, which was accompanied with increases in cleaved Poly (ADP-ribose) polymerase (PARP) and caspase-3 in HCC cells...
July 4, 2018: Phytotherapy Research: PTR
Weiwei Luo, Xin Liu, Wen Sun, Jin-Jian Lu, Yitao Wang, Xiuping Chen
Epithelial-mesenchymal transition (EMT) plays important roles in the metastasis of solid tumors. In this study, the effect of toosendanin (TSN), a natural insecticide extracted from Melia toosendan Sieb et Zucc, on transforming growth factor-β1 (TGF-β1)-induced EMT was investigated. EMT was induced by TGF-β1 in A549 and H1975 lung cancer cells. The morphological alterations were observed with a microscopy. The protein expression and localization of EMT biomarkers were determined by Western blotting and immunofluorescence...
June 28, 2018: Phytotherapy Research: PTR
Fariborz Mansour-Ghanaei, Amir Hadi, Makan Pourmasoumi, Farahnaz Joukar, Sahar Golpour, Ameneh Najafgholizadeh
This study aimed to evaluate the efficacy of green tea supplementation on nonalcoholic fatty liver disease treatment. Electronic databases, including PubMed, Scopus, Web of Science, and Google Scholar, were systematically searched up to October 30, 2017, to identify eligible trials based on the inclusion criteria. The effect size was presented as mean difference with 95% confidence intervals (CI). The meta-analysis of data from four studies indicated significant effects of green tea supplementation in altering alanine aminotransferases (-12...
June 27, 2018: Phytotherapy Research: PTR
Zahra Nikakhtar, Malihe Hasanzadeh, Shokouh Sadat Hamedi, Mona Najaf Najafi, Amir Parviz Tavassoli, Zohre Feyzabadi, Zahra Meshkat, Azadeh Saki
Human papillomavirus (HPV) can be detected in most of cervical cancers. Due to antiviral, antimutagenic, and proapoptotic activities of myrtle, this study was designed to investigate the effect of a herbal suppository based on myrtle in cervicovaginal HPV infections. This study was performed as a double-blind randomized trial at the Clinic of Traditional Medicine in Mashhad University of Medical Sciences between 2016 and 2017. Sixty women, 18 to 50 years old, with cervicovaginal HPV infection, were included and randomly allocated to two groups...
June 26, 2018: Phytotherapy Research: PTR
Christian Vlachojannis, Sigrun Chrubasik-Hausmann, Elmar Hellwig, Kirstin Vach, Ali Al-Ahmad
Due to continuous rise in antibiotic resistance, there is a need for alternative treatment options to reduce the levels of oral pathogens for the maintenance of oral as well as overall health. The aim of this study was to evaluate the in vitro antibacterial potential of tinctures of Spilanthes oleracea and propolis, Nigella seed oil, and an ethanolic extract of black garlic on microorganisms involved in oral diseases. Both the minimum inhibitory concentration assay and the minimum bactericidal/fungicidal concentration assay were used in this study...
June 25, 2018: Phytotherapy Research: PTR
Angelo A Izzo
No abstract text is available yet for this article.
June 19, 2018: Phytotherapy Research: PTR
Mehrnoosh Sedighi, Afshin Nazari, Mahdieh Faghihi, Mahmoud Rafieian-Kopaei, Arash Karimi, Maryam Moghimian, Seyyed Ali Mozaffarpur, Marzieh Rashidipour, Mehrdad Namdari, Mostafa Cheraghi, Bahram Rasoulian
Cinnamomum zeylanicum (cinnamon) is a plant with potent antioxidant activity and has been used in traditional medicine for improvement of heart function. The effects of cinnamon bark ethanolic extract were investigated against ischemia-induced arrhythmias and heart injury in an in vivo rat model of regional heart ischemia. The extract was also standardized, and its antioxidant activity was evaluated. Adult male Sprague-Dawley rats were subjected to 30 min of ischemia by occlusion of the left anterior descending coronary artery followed by 5 days of reperfusion...
June 19, 2018: Phytotherapy Research: PTR
Ashish Dhir
Curcumin, a principal curcuminoid present in turmeric, has an antioxidant, anti-inflammatory and neuroprotective properties. Preclinical studies have indicated its beneficial effect for the treatment of epilepsy disorders. The molecule has an anti-seizure potential in preclinical studies, including chemical and electrical models of acute and chronic epilepsy. Curcumin also possesses an anti-epileptogenic activity as it reduces spontaneous recurrent seizures severity in a kainate model of temporal lobe epilepsy...
June 19, 2018: Phytotherapy Research: PTR
Dong Hee Kim, Eun Ah Shin, Bonglee Kim, Bum Sang Shim, Sung-Hoon Kim
Though Tanshinone I (Tan I), a phenolic compound from Salvia miltiorrhiza, is known to have anticancer activity in several cancers, its anticancer mechanisms are not fully understood in colon cancer cells. Thus, in the present study, the underlying molecular mechanism of Tan I was explored in HCT116 and HT29 colorectal cancer cells (CRCs). Here, Tan I suppressed viability in HCT116 and HT29 cells in a time- and dose-dependent manner. Also, Tan I increased the number of terminal deoxynucleotide transferase-mediated dUTP nick end labeling (TUNEL)-positive cells and sub-G1 population in HCT116 and HT29 cells...
June 7, 2018: Phytotherapy Research: PTR
Mona Najaf Najafi, Maryam Salehi, Masumeh Ghazanfarpour, Zeinab Sadat Hoseini, Majid Khadem-Rezaiyan
This systematic review and meta-analysis aimed to critically evaluate the relation between green tea (GT) consumption and the risk of breast cancer. Popular electronic databases were systematically searched for papers in English language. All case-control and cohort studies in addition to randomized clinical trials were included if they assessed the chemopreventive effects of GT on breast cancer. The quality of included studies was assessed using the Newcastle-Ottawa and Jadad scale. This systematic review comprised 14 studies: 9 case-control studies, 4 cohort studies, and 1 clinical trial...
June 7, 2018: Phytotherapy Research: PTR
Harini Anandhi Senthilkumar, Jimmie E Fata, Edward J Kennelly
Phytoestrogens, a class of plant-derived compounds that are structural mimics of estrogen, can bind to estrogen receptors, acting as either agonists or antagonists. They have been implicated in estrogen-mediated physiology, which makes them interesting targets of study, especially for biomedical applications in woman's health. The 1998 Women's Health Initiative sparked considerable interest in natural alternatives to hormone replacement therapy, thereby triggering many additional studies on phytoestrogens. In this review, key advancements in dietary phytoestrogens are addressed, emphasizing their relation to breast pathophysiology...
June 7, 2018: Phytotherapy Research: PTR
Jiamei Ma, Ganghui Yin, Zibin Lu, Pei Xie, Hongling Zhou, Junshan Liu, Linzhong Yu
Casticin, a compound purified from the Chinese herb Viticis Fructus, has been proven effective in preventing tumor progression in previous studies. Ulcerative colitis (UC) is a common inflammatory bowel disease that affects millions of people worldwide, but no effective and safe drugs are available. In this study, we aimed to study how did casticin affect UC by evaluating its effects on dextran sulfate sodium (DSS)-induced colitis in mice. Our data suggested that casticin attenuated body weight loss, colon length shortening, and pathological damage in the colon of DSS-treated mice...
June 7, 2018: Phytotherapy Research: PTR
Parneet Kaur Deol, Pragyanshu Khare, Mahendra Bishnoi, Kanthi Kiran Kondepudi, Indu Pal Kaur
Aim of the study was to evaluate a combination of ginger extract (GE; antioxidant, anti-inflammatory) and Lactobacillus acidophilus (LAB; probiotic), in DMH-DSS-induced inflammation-driven colon cancer, in Wistar rats. Effect of varying GE concentration on growth of LAB was assessed in vitro. Colonic histology and permeability, oxidative stress, serum proinflammatory cytokines, expression of selected genes, gut bacteria, and SCFA determination of gut content was monitored after treatment with agents alone or in combination, postdisease induction...
June 7, 2018: Phytotherapy Research: PTR
Feng-Qin Zhu, Juan Hu, Fa-Hui Lv, Pan Cheng, Shan Gao
The aim of this study was to investigate the effects of Grape Seed Proanthocyanidins (GSP) on Nω-Nitro-L-arginine methyl ester-induced hypertension in pregnant mice. Fifty Kunming mice were randomized into control, control + GSP, model, and model + GSP. Three weeks later, the artery systolic blood pressure was examined and the related pathological changes were detected. Aorta relaxation function was assessed by aorta ring apparatus. Blood urea nitrogen and serum creatinine were measured by an automatic biochemistry analyzer...
May 31, 2018: Phytotherapy Research: PTR
Ashish Dogra, Shipra Bhatt, Asmita Magotra, Anjna Sharma, Pankul Kotwal, Abhishek Gour, Priya Wazir, Gurdarshan Singh, Utpal Nandi
Curcumin, a natural diarylheptanoid, is extensively used as a food additive or dietary supplement on the regular basis. It is known to have potential to encumber the drug transporters and hepatic drug metabolizing enzymes that lead to pharmacokinetic interactions with drug or food. Daclatasvir is a new orally acting drug for the treatment of chronic Hepatitis C Virus infections. This is a substrate of P-glycoprotein and CYP3A4 that are involved in the major pharmacokinetic interaction. Hence, the studies' aim is to assess for any possible pharmacokinetic interactions...
May 28, 2018: Phytotherapy Research: PTR
Elahe Mohammadi, Ahmad Tamaddoni, Durdi Qujeq, Esmat Nasseri, Farid Zayeri, Hamid Zand, Mahdi Gholami, Seyed Mostafa Mir
This study investigated the effects of curcumin, the active polyphenol in turmeric, on iron overload, hepcidin level, and liver function in β-thalassemia major patients. This double-blind randomized controlled clinical trial was conducted on 68 β-thalassemia major patients. The subjects were randomly divided into 2 groups to receive either 500 mg curcumin capsules (total: 1,000 mg) twice daily or placebo for 12 weeks. Dietary intakes and biochemical variables including hemoglobin, transferrin saturation, total iron binding capacity, nontransferrin bound iron (NTBI), ferritin, hepcidin, alanine aminotransferase (ALT), and aspartate aminotransferase (AST) were assessed at the beginning and end of the trial...
May 28, 2018: Phytotherapy Research: PTR
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