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Phytotherapy Research: PTR

Stuti Chhabra, Tripti Mishra, Yogesh Kumar, Gatha Thacker, Sanjeev Kanojiya, Naibedya Chattopadhyay, Tadigoppula Narender, Arun Kumar Trivedi
Chebulinic acid, an ellagitannin found in the fruits of Terminalia chebula, has been extensively used in traditional Indian system of medicine. It has shown to have various biological activities including antitumor activity. The present study aims to investigate the cytotoxic potential of chebulinic acid in human myeloid leukemia cells. Interestingly, chebulinic acid caused apoptosis of acute promyelocytic leukemia HL-60 and NB4 cells but not K562 cells. In vitro antitumor effects of chebulinic acid were investigated by using various acute myeloid leukemia cell lines...
September 18, 2017: Phytotherapy Research: PTR
Ra-Yeong Choi, Ju Ri Ham, Hae-In Lee, Hyun Wook Cho, Myung-Sook Choi, Seok-Kyu Park, Jin Lee, Myung-Joo Kim, Kwon-Il Seo, Mi-Kyung Lee
Scopoletin is a bioactive component in many edible plants and fruits. This study investigated the effects of scopoletin on hepatic steatosis and inflammation in a high-fat diet fed type 1 diabetic mice by comparison with metformin. Scopoletin (0.01%, w/w) or metformin (0.5%, w/w) was provided with a high-fat diet to streptozotocin-induced diabetic mice for 11 weeks. Both scopoletin and metformin lowered blood glucose and HbA1c , serum ALT, TNF-α and IL-6 levels, glucose intolerance, and hepatic lipid accumulation compared with the diabetic control group...
September 18, 2017: Phytotherapy Research: PTR
Jung A Lee, Young-Rak Cho, Seong Su Hong, Eun-Kyung Ahn
Saringosterol, a steroid isolated from Sargassum muticum, a brown edible alga widely distributed on the seashores of southern and eastern Korea, has been shown to exhibit anti-obesity effect. In this study, we investigated the anti-obesity activity of saringosterol through various experiments. The inhibitory effect of saringosterol on adipogenesis was evaluated via Oil Red O staining in 3T3-L1 preadipocytes. After confirming that saringosterol is not cytotoxic to these cells by using the 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide assay, the effect of saringosterol on the expression of various adipogenesis-related genes was analyzed via quantitative real-time polymerase chain reaction and western blotting...
September 18, 2017: Phytotherapy Research: PTR
Zahra Razani, Mostafa Dastani, Hamid Reza Kazerani
Ischemic heart disease is the leading cause of mortality worldwide. The purpose of this study was to evaluate the cardioprotective effects of pomegranate juice in patients with ischemic heart disease. One hundred patients, diagnosed with unstable angina or myocardial infarction, were randomly assigned to the test and the control groups (n = 50, each). During 5 days of hospitalization, in addition to the conventional medical therapies, the test groups received 220 mL pomegranate juice, daily. During the hospitalization period, the blood pressure, heart rate, as well as the intensity, occurrence, and duration of the angina were evaluated on a regular basis...
September 15, 2017: Phytotherapy Research: PTR
Sukvinder K Bhamra, Adrian Slater, Caroline Howard, Mark Johnson, Michael Heinrich
Migrant South Asian communities in the UK have brought with them their own traditional forms of medicine, yet little is known about their current use of herbal medicines (HMs) in the UK. The aim of the study was to explore the origins, use and transmission of knowledge of traditional HMs used by diasporic South Asian communities in the UK. A researcher-administered questionnaire was used for data collection (n = 192). An opportunity sampling technique was used to recruit participants across several locations in Birmingham and Leicester...
September 14, 2017: Phytotherapy Research: PTR
Alexandra R Vaughn, Kelly N Haas, Waqas Burney, Erich Andersen, Ashley K Clark, Robert Crawford, Raja K Sivamani
Turmeric root (Curcuma longa) is predominantly used as a spice, but has also long been known to possess antimicrobial, analgesic, antiinflammatory, and anticancer properties. One predominant group of active compounds in turmeric are curcuminoids, namely bright yellow-pigmented curcumin. While modern science has yet to fully investigate the therapeutic claims of turmeric and its derivatives, results have proven promising in decreasing pain and inflammation in arthritis, improving insulin sensitivity in diabetes, and even curing a variety of infections...
September 7, 2017: Phytotherapy Research: PTR
Stephen L Atkin, Niki Katsiki, Giuseppe Derosa, Pamela Maffioli, Amirhossein Sahebkar
Curcumin is a naturally occurring polyphenol that has been suggested to improve several metabolic diseases. Leptin is an adipokine involved in metabolic status and appetite, with marked crosstalk with other systems. Available data suggest that curcumin may affect leptin levels; therefore, this meta-analysis was performed to evaluate this. A systematic review and meta-analysis were undertaken on all randomized controlled trials of curcumin studies that included the measurement of leptin. The search included PubMed-Medline, Scopus, ISI Web of Knowledge, and Google Scholar databases...
September 7, 2017: Phytotherapy Research: PTR
Mariana Del Grossi Moura, Luciane Cruz Lopes, Maique Weber Biavatti, Sean Alexander Kennedy, Maria Carolina de Oliveira E Silva, Marcus Tolentino Silva, Cristiane de Cássia Bergamaschi
Herbal medications are commonly used to manage symptoms associated with osteoarthritis (OA). This systematic review evaluated the effectiveness and safety of oral medications used in Brazil for the treatment of OA. Randomized clinical trials involving adults with OA treated by a herbal medicine or a control group were eligible. The primary outcomes measured were pain, physical function, swelling, stiffness and quality of life; and the secondary outcomes were adverse events, activity limitations and treatment satisfaction...
September 5, 2017: Phytotherapy Research: PTR
María Rosario Alonso, Ignacio Peralta, Demian Monti, Renzo Martino, Claudia Anesini
Larrea divaricata Cav. (Zygophyllaceae) is a South American plant widely distributed in Argentina that is used in folk medicine to treat inflammatory diseases. The aqueous extract is known to have well-documented biological activities such as antitumour, immunomodulatory, antimicrobial, antiinflammatory and antioxidant. However, its stability in gastrointestinal fluids is unknown. The latter is an important factor to assure the bioavailability of plant extracts intended to be administered via the oral route...
August 31, 2017: Phytotherapy Research: PTR
Mehdi Dadashpour, Younes Pilehvar-Soltanahmadi, Nosratollah Zarghami, Akram Firouzi-Amandi, Mohammad Pourhassan-Moghaddam, Mohammad Nouri
To reach ideal therapeutic potential of stem cells for regenerative medicine purposes, it is essential to retain their self-renewal and differentiation capacities. Currently, biological factors are extensively used for stemness maintaining and differentiation induction of stem cells. However, low stability, high cost, complicated production process, and risks associated with viral/endotoxin infection hamper the widespread use of biological factors in the stem cell biology. Moreover, regarding the modulation of several signaling cascades, which lead to a distinct fate, phytochemicals are preferable in the stem cells biology because of their efficiency...
August 31, 2017: Phytotherapy Research: PTR
Jing-Ru Weng, Li-Yuan Bai, Wei-Yu Lin
Peroxisome proliferator-activated receptor γ (PPARγ), one of the transcription factors that regulate lipid metabolism and energy use in tumor cells, is a viable target for cancer therapy. In our search for potential PPARγ activator, extracts from five Formosan plants were tested. Among them, Momordica charantia L. showed the highest ability to activate PPARγ, which led us to identify its potential constituents. Among the seven compounds isolated from M. charantia, a triterpenoid, 5β,19-epoxy-19-methoxycucurbita-6,23-dien-3β,25-diol (compound 1), was identified as a PPARγ activator with an IC50 of 10 μM in breast cancer MCF-7 cells...
August 30, 2017: Phytotherapy Research: PTR
Cindy Romain, Tomás T Freitas, Francisco J Martínez-Noguera, Caroline Laurent, Sylvie Gaillet, Linda H Chung, Pedro E Alcaraz, Julien Cases
High-intensity exercises are known to provoke delayed onset muscle soreness (DOMS). Delayed onset muscle soreness typically occurs within the first 24 h, peaks between 24 and 72 h, and can last as long as 5-7 days post-exercise. Delayed onset muscle soreness is a multifactorial process involving both mechanical and biochemical components, associated with clinical features that may limit range of motion, and athletes seek for effective recovery strategies to optimize future training sessions. TensLess(®) is a food supplement developed to help manage post-exercise recovery...
August 30, 2017: Phytotherapy Research: PTR
Ju-Hee Lee, Young Hoon Son, Young-Won Kwon, Sung Yun Park, Byung-Soo Koo, Seung Hyun Jung
An H9 is a formula of nine medicinal herbs derived from Osuyubujaijung-tang, a traditional Korean prescription for Soeumin constitution. In our previous study, H9 showed anticancer effects against breast cancer and non-small-cell lung cancer. However, the underlying mechanisms of these effects have not yet been elucidated. In this study, we investigated the effects of H9, both alone and in combination with trastuzumab, on breast cancer cells and sought to elucidate the mechanisms involved. H9 suppressed the proliferation of human breast cancer cells, induced arrest of the cell cycle at the G0/G1 phase, and caused mitochondrial dysfunction and apoptosis...
August 30, 2017: Phytotherapy Research: PTR
David Wing-Shing Cheung, Chi-Man Koon, Pui-Han Wong, Ka-Chun Yau, Elaine Wat, Angela Sze-Man Hung, Yan-Ping Wang, Kit-Man Lau, Chun-Hay Ko, Judy Yuet-Wa Chan, Mary Miu-Yee Waye, Kwok-Pui Fung
Despite being a potent hypolipidemic drug, atorvastatin (AS) possesses certain adverse effects. Using AS and an herbal formula (Danshen and Gegen, DG) in combination may achieve potentiated hypolipidemic effects and also reduce its adverse effects. Hence, this study aimed to investigate the efficacy and safety of an AS and DG combination on high-fat diet-induced hyperlipidemia. Treatment outcomes were assessed by measuring parameters including body weight, adipose tissue, liver, total cholesterol, triglyceride, and low-density and high-density lipoprotein cholesterol...
August 25, 2017: Phytotherapy Research: PTR
Fernanda Guilhon-Simplicio, Tallita Marques Machado, Leandro Flores do Nascimento, Rayanne da Silva Souza, Hector Henrique Ferreira Koolen, Felipe Moura Araújo da Silva, Leonard Domingo Rosales Acho, Adair Roberto Soares Dos Santos, Paul Cos, Maria de Meneses Pereira, Emerson Silva Lima
Species of the Byrsonima genus are widely used in Brazil, especially for the treatment of gastrointestinal disorders. However, species from the Amazonian region are still poorly studied. Thus, we studied the antioxidant, antinociceptive, and anti-inflammatory activities of for Amazonian species, Byrsonima crispa, Byrsonima duckeana, Byrsonima garcibarrigae, and Byrsonima incarnata. Phenolic composition was determined by chemical and chromatographic methods. The aqueous extracts were evaluated in DPPH(•) , ABTS(+•) , and superoxide (O2(•-) ) tests, LPS-activated macrophage assay, and formalin test...
August 25, 2017: Phytotherapy Research: PTR
Gisele França da Costa, Izabelle Barcellos Santos, Graziele Freitas de Bem, Viviane Silva Cristino Cordeiro, Cristiane Aguiar da Costa, Lenize Costa Reis Marins de Carvalho, Dayane Teixeira Ognibene, Angela Castro Resende, Roberto Soares de Moura
We hypothesized that a polyphenol-rich extract from Vitis vinifera L. grape skin (GSE) may exert beneficial effects on obesity and related metabolic disorders induced by a high-fat diet (HFD). C57/BL6 mice were fed a standard diet (10% fat, control, and GSE groups) or an HFD (60% fat, high fat (HF), and HF + GSE) with or without GSE (200 mg/kg/day) for 12 weeks. GSE prevented weight gain; dyslipidemia; insulin resistance; the alterations in plasma levels of leptin, adiponectin, and resistin; and the deregulation of leptin and adiponectin expression in adipose tissue...
August 25, 2017: Phytotherapy Research: PTR
Xiaofeng Niu, Zehong He, Weifeng Li, Xiumei Wang, Wenbing Zhi, Fang Liu, Lin Qi
The yam (Dioscorea opposita Thunb) is a well-known edible food and widely used as the traditional Chinese medicine. The present investigation was designed to evaluate the immunomodulatory activity of glycoprotein (DOT) from yam and explore its possible molecular mechanisms. Results showed that the DOT could improve the cell immunity, humoral immunity and phagocytic system function of the normal mice. The DOT could also increase the production of TNF-α, interleukin-6 and nitric oxide and enhance the pinocytosis function of macrophages...
August 25, 2017: Phytotherapy Research: PTR
Cicero Diego Almino Menezes, Francisca Adilfa de Oliveira Garcia, Glauce Socorro de Barros Viana, Patricia Gonçalves Pinheiro, Cícero Francisco Bezerra Felipe, Thaís Rodrigues de Albuquerque, Alisson Cordeiro Moreira, Enaide Soares Santos, Maynara Rodrigues Cavalcante, Tatiana Rodrigues Garcia, Thiago Fonseca Silva, Henrique Douglas Melo Coutinho, Irwin Rose Alencar de Menezes
Orange jasmine, Murraya paniculata (Rutaceae), is a plant from India widely used in folk medicine as antinociceptive, antiinflammatory, and antioxidant. Although oral hypoglycemic agents and insulin are the mainstays of treatment of diabetes mellitus (DM), there is a significant demand for new natural products to reduce the development of diabetic complications. Alloxan-induced diabetic rats were treated for 60 days with a hydroalcoholic extract of M. paniculata (MPE), at doses of 100, 200, and 400 mg/kg...
August 25, 2017: Phytotherapy Research: PTR
Maryam Ghazimoradi, Maryam Saberi-Karimian, Farzane Mohammadi, Amirhossein Sahebkar, Shima Tavallaie, Hamideh Safarian, Gordon A Ferns, Majid Ghayour-Mobarhan, Mohsen Moohebati, Habibollah Esmaeili, Malihe Ahmadinejad
Metabolic syndrome (MetS) is defined by a clustering of metabolic and anthropometric abnormalities and is associated by an increased risk of cardiovascular disease. We have investigated the effect of curcumin supplementation on the serum pro-oxidant-antioxidant balance (PAB) in patients with MetS. This double-blind, randomized, placebo-controlled trial was conducted over 6 weeks. Subjects (n = 120) were randomly allocated to one of three groups (curcumin, phospholipidated curcumin, and placebo). The curcumin group received 1 g/day of simple curcumin, the phospholipidated curcumin group received 1 g/day of phospholipidated curcumin (containing 200 mg of pure curcumin), and the control group received 1 g/day of placebo...
August 25, 2017: Phytotherapy Research: PTR
Hafiz Muhammad Abdur Rahman, Samra Bashir, Safur Rehman Mandukhail, Sohaib Huda, Anwarul Hassan Gilani
Achyranthes aspera L. is traditionally used to relieve constipation, diarrhea, and asthma. Its crude extract (Aa.Cr) was evaluated through in vivo and ex vivo experiments to rationalize these medicinal uses of A. aspera and to provide their scientific basis. Aa.Cr, at 3 and 10 mg/kg, increased fecal output, similar to castor oil, whereas at 30, 100, 300, and 700 mg/kg, it protected against castor oil-induced diarrhea in mice when administered orally. Aa.Cr caused spasmogenic effect on rabbit jejunum and guinea pig ileum preparations, which was partially inhibited by atropine while completely blocked by cyproheptadine preincubation...
August 25, 2017: Phytotherapy Research: PTR
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