journal
MENU ▼
Read by QxMD icon Read
search

Phytotherapy Research: PTR

journal
https://www.readbyqxmd.com/read/29131443/a-systematic-review-of-randomized-controlled-trials-with-herbal-medicine-on-chronic-rhinosinusitis
#1
REVIEW
Majid Anushiravani, Mahdi Bakhshaee, Ali Taghipour, Hamideh Naghedi-Baghdar, Masoumeh Kaboli Farshchi, Seyed Saeed Hoseini, Mohammad Reza Mehri
Chronic rhinosinusitis (CRS) is a common disease with evidence to show that its incidence and prevalence are increasing. Medicinal plants are commonly used to treat CRS. This systematic review aimed to assess the effectiveness and safety of herbal preparations for treatment of the patients with CRS. Cochran, Embase, ISI, PubMed, and Scopus databases were searched until August 1, 2016. Only randomized controlled trials were included. Four randomized controlled trials were included in this systematic review. Various medicinal plants were studied in each article...
November 12, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29130614/panax-notoginseng-saponins-attenuate-cardiomyocyte-apoptosis-through-mitochondrial-pathway-in-natural-aging-rats
#2
Zhiyong Zhou, Jiao Wang, Yanan Song, Yumin He, Changcheng Zhang, Chaoqi Liu, Haixia Zhao, Yaoyan Dun, Ding Yuan, Ting Wang
Panax notoginseng saponins (PNS) have been widely used in the cardiovascular system for the treatment of cardiovascular diseases and stroke in China. In this study, we investigated the anti-apoptotic effect of PNS on cardiomyocytes in the natural aging rat and explored the potential mechanisms regarding oxidative stress and mitochondrial function signaling pathways. Male Sprague-Dawley rats were randomly divided into five groups: adult control (3-month old), aging control (24-month old), and different doses of PNS-treated aging rat groups (10, 30, 60 mg/kg/day, orally)...
November 12, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29130588/effects-of-astragalus-extract-mixture-ht042-on-height-growth-in-children-with-mild-short-stature-a-multicenter-randomized-controlled-trial
#3
Donghun Lee, Sun Haeng Lee, Jungbin Song, Hee-Jung Jee, Sung Ho Cha, Gyu Tae Chang
HT042 is a standardized functional food ingredient approved by Korean Food and Drug Administration with a claim 'HT042 can help height growth of children'. We aimed to evaluate the safety and efficacy of HT042 on height growth in children with mild short stature. A multicenter, randomized, double-blind, placebo-controlled parallel study was performed on children aged 6-8 years with height ranked below the 25th percentile. In 129 children, height gain was significantly higher in HT042 group than placebo group after 24 weeks (mean difference, 0...
November 12, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29130543/medicinal-plants-of-the-genus-macleaya-macleaya-cordata-macleaya-microcarpa-a-review-of-their-phytochemistry-pharmacology-and-toxicology
#4
REVIEW
Li Lin, Yan-Chun Liu, Jia-Lu Huang, Xiu-Bin Liu, Zhi-Xing Qing, Jian-Guo Zeng, Zhao-Ying Liu
In the genus Macleaya, Macleaya cordata and Macleaya microcarpa have been recognized as traditional herbs that are primarily distributed in China, North America, and Europe and have a long history of medicinal usage. These herbs have been long valued and studied for detumescence, detoxification, and insecticidal effect. This review aims to provide comprehensive information on botanical, phytochemical, pharmacological, and toxicological studies on plants in the genus Macleaya. Plants from the genus of Macleaya provide a source of bioactive compounds, primarily alkaloids, with remarkable diversity and complex architectures, thereby having attracted attention from researchers...
November 12, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29130542/safety-evaluation-of-p-synephrine-following-15%C3%A2-days-of-oral-administration-to-healthy-subjects-a-clinical-study
#5
Mohd Shara, Sidney J Stohs, Mahmoud M Smadi
Extracts of bitter orange (BOE, Citrus aurantium L.) and its primary protoalkaloid p-synephrine are extensively consumed as dietary supplements. p-Synephrine is also present in foods and juices prepared from various Citrus species. The safety of p-synephrine has been questioned as a result of structural similarities with ephedrine. This study assessed the cardiovascular (stimulant) and hemodynamic effects of BOE (49 mg p-synephrine) daily given to 16 healthy subjects for 15 days in a placebo-controlled, cross-over, double-blinded study...
November 12, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29130532/the-impact-of-argan-oil-on-plasma-lipids-in-humans-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#6
REVIEW
Sorin Ursoniu, Amirhossein Sahebkar, Maria-Corina Serban, Maciej Banach
The study aims to investigate the effect of argan oil on plasma lipid concentrations through a systematic review of the literature and a meta-analysis of available randomized controlled trials. Randomized controlled trials that investigated the impact of at least 2 weeks of supplementation with argan oil on plasma/serum concentrations of at least 1 of the main lipid parameters were eligible for inclusion. Effect size was expressed as the weighted mean difference (WMD) and 95% confidence interval (95% CI). Meta-analysis of data from 5 eligible trials with 292 participants showed a significant reduction in plasma concentrations of total cholesterol (WMD: -16...
November 12, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29071768/protective-effect-of-salvianolic-acid-a-on-ischaemia-reperfusion-acute-kidney-injury-in-rats-through-protecting-against-peritubular-capillary-endothelium-damages
#7
Zuokai Zhang, Dong Qi, Xuekai Wang, Zhenfang Gao, Peng Li, Wenbo Liu, Xiao Tian, Yue Liu, Mingyan Yang, Ke Liu, Huaying Fan
Renal ischaemia-reperfusion (I/R) injury is the most common cause of acute kidney injury (AKI). Peritubular capillary (PTC) endothelium damages are an important pathogenesis during I/R AKI. Salvianolic acid A (SAA) possesses various pharmacological activities. The study investigated whether SAA ameliorated I/R AKI through protecting against PTC endothelium damages. Male Sprague-Dawley rats were divided into 6 groups: control, sham, I/R, and I/R plus SAA (2.5, 5, 10 mg/kg) groups. Rats were subjected to bilateral renal pedicle clamping for 60 min, and killed at 24 hr after reperfusion...
October 26, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29071751/pxr-mediated-induction-of-cyp3a4-cyp1a2-and-p-gp-by-mitragyna-speciosa-and-its-alkaloids
#8
Vamshi K Manda, Bharathi Avula, Olivia R Dale, Zulfiqar Ali, Ikhlas A Khan, Larry A Walker, Shabana I Khan
Kratom (Mitragyna speciosa), a native herb of Southeast Asia, is widely known for its psychoactive properties. Recent increase in the use of kratom as a recreational drug has increased the risk of its interaction with conventional drugs if taken concomitantly. A few reports are available related to the effects of kratom on the activity of cytochrome P450 enzymes (CYPs), but there are no reports of its effects on pregnane X receptor (PXR), a transcription factor that regulates the expression of CYPs and P-glycoprotein (P-gp)...
October 26, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29067744/scopoletin-standardized-morinda-elliptica-leaf-extract-suppressed-inflammation-and-cartilage-degradation-to-alleviate-osteoarthritis-a-preclinical-study
#9
Wan Nurfarahin Wan Osman, Seng Fong Lau, Suhaila Mohamed
The effect of scopoletin-standardized Morinda elliptica leaf extract against osteoarthritis was investigated in ex vivo explant culture and preclinical rodent model. Thirty male rats were grouped (n = 6) into untreated osteoarthritis (OA), OA + Diclofenac (5 mg/kg), and OA + extract (200 and 400 mg/kg) and compared with healthy control. Monosodium iodoacetate were injected into the right intra-articular knee joints to induce OA. The rats were evaluated for OA severity via physical (micro-CT and histological observations), biochemical, ELISA, and mRNA expression analysis (for inflammation and cartilage degradation biomarkers), after 28 days of treatment...
October 25, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29047215/acute-cardiovascular-effects-of-bitter-orange-extract-p-synephrine-consumed-alone-and-in-combination-with-caffeine-in-human-subjects-a-placebo-controlled-double-blind-study
#10
Nicholas A Ratamess, Jill A Bush, Sidney J Stohs, Nicole L Ellis, Ira T Vought, Elizabeth A O'Grady, Jeremy D Kuper, Saif B Hasan, Jie Kang, Avery D Faigenbaum
The purpose was to examine cardiovascular responses to supplementation with p-synephrine alone and in combination with caffeine during quiet sitting. Sixteen subjects were given (in double-blind manner) either 103 mg of p-synephrine (S), 233 mg of caffeine +104 mg of p-synephrine (LC + S), 240 mg of caffeine (LC), 337 mg of caffeine +46 mg of p-synephrine (HC + S), 325 mg of caffeine (HC), or a placebo. The subjects sat quietly for 3 hr while heart rate (HR) and blood pressure were measured. Only HC + S and HC significantly increased mean systolic blood pressure (SBP) during the second hour and tended to increase mean SBP during the third hour...
October 19, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29047177/selected-hepatoprotective-herbal-medicines-evidence-from-ethnomedicinal-applications-animal-models-and-possible-mechanism-of-actions
#11
REVIEW
Muhammad Ali, Tariq Khan, Kaneez Fatima, Qurat Ul Ain Ali, Muhammad Ovais, Ali Talha Khalil, Ikram Ullah, Abida Raza, Zabta Khan Shinwari, Muhammad Idrees
Insight into the hepatoprotective effects of medicinally important plants is important, both for physicians and researchers. Main reasons for the use of herbal medicine include their lesser cost compared with conventional drugs, lesser undesirable drug reactions and thus high safety, and reduced side effects. The present review focuses on the composition, pharmacology, and results of experimental trials of selected medicinal plants: Silybum marianum (L.) Gaertn., Glycyrrhiza glabra, Phyllanthus amarus Schumach...
October 19, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29044868/effects-of-rubiadin-isolated-from-prismatomeris-connata-on-anti-hepatitis-b-virus-activity-in-vitro
#12
Zheng Peng, Gang Fang, Fenghui Peng, Zhiyu Pan, Zhengying Su, Wei Tian, Danrong Li, Huaxin Hou
Prismatomeris connata was a kind of Rubiaceae plant for treatment of hepatitis, hepatic fibrosis and silicosis. Whereas, the effective components of Prismatomeris connata remains unexplored. The aim of this study was to investigate the inhibitory effects and mechanisms of Rubiadin isolated from Prismatomeris connata against HBV using HepG2.2.15 cells. The levels of hepatitis B surface antigen (HBsAg), hepatitis B e antigen (HBeAg), and hepatitis B core antigen (HBcAg) in the supernatants or cytoplasm were examined using by enzyme-linked immunosorbent assay...
October 18, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29044858/pharmacological-and-chemical-features-of-nepeta-l-genus-its-importance-as-a-therapeutic-agent
#13
REVIEW
Ipek Süntar, Seyed Mohammad Nabavi, Davide Barreca, Nicolas Fischer, Thomas Efferth
Medicinal plants have always had great value for the human population due to their valuable constituents and potential bioactivities. The objective of this review is to present an updated overview of an important medicinal plant genus Nepeta L., from the family Lamiaceae, revealing its traditional utilization, biological activity, phytoconstituents, and mechanisms of action. For this purpose, a literature survey was carried out by using SciFinder, ScienceDirect, Scopus, PubMed, and Web of Science followed by a revision of the bibliographies of the related articles...
October 18, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29044755/epoxyazadiradione-purified-from-the-azadirachta-indica-seed-induced-mitochondrial-apoptosis-and-inhibition-of-nf%C3%AE%C2%BAb-nuclear-translocation-in-human-cervical-cancer-cells
#14
G Shilpa, J Renjitha, R Saranga, Francis K Sajin, Mangalam S Nair, Beena Joy, B S Sasidhar, S Priya
Epoxyazadiradione (EAD) is an important limonoid present in Neem (Azadirachta indica) plant. In the present study, we have purified EAD from Neem seed and studied its anticancer potential in human cervical cancer (HeLa) cells. Cell proliferation inhibition studies indicated that the GI50 value of EAD is 7.5 ± 0.0092 μM in HeLa cells, whereas up to 50 μM concentrations EAD did not affect the growth of normal H9C2 cells. The control drug cisplatin inhibited the growth of both HeLa and H9C2 cells with a GI50 value of 2...
October 18, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29044703/a-comparative-study-on-the-effect-of-promoting-the-osteogenic-function-of-osteoblasts-using-isoflavones-from-radix-astragalus
#15
Xianghe Kong, Fang Wang, Yinbo Niu, Xianglong Wu, Yalei Pan
Radix Astragalus has been shown to exert beneficial effects regarding the prevention postmenopausal osteoporosis. However, its mechanism of action remains to be investigated. Calycosin, formononetin, and calycosin-7-O-β-d-glucoside are the main isoflavone constituents of Astragalus. In this study, the abilities of these 3 compounds to promote osteogenic function of osteoblasts were compared, and the structure-activity relationships of these osteotrophic isoflavones were determined. Calycosin exhibited a greater effect than formononetin and calycosin-7-O-β-d-glucoside regarding improvements in osteogenic function of osteoblasts, as demonstrated by cell proliferation, alkaline phosphatase activity, collagen I and osteocalcin secretion, and the number and area of mineralized bone nodules...
October 18, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29044876/chelidonine-inhibits-tnf-%C3%AE-induced-inflammation-by-suppressing-the-nf-%C3%AE%C2%BAb-pathways-in-hct116-cells
#16
Zhi Hong Zhang, Chunliu Mi, Ke Si Wang, Zhe Wang, Ming Yue Li, Hong Xiang Zuo, Guang Hua Xu, Xuezheng Li, Lian Xun Piao, Juan Ma, Xuejun Jin
Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) is a complex that regulates several hundreds of genes, including those involved in immunity and inflammation, survival, proliferation, and the negative feedback of NF-κB signaling. Chelidonine, a major bioactive, isoquinoline alkaloid ingredient in Chelidonium majus, exhibits antiinflammatory pharmacological properties. However, its antiinflammatory molecular mechanisms remain unclear. In this work, we explored the effect of chelidonine on TNF-induced NF-κB activation in HCT116 cells...
October 17, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29027311/natural-compound-licochalcone-b-induced-extrinsic-and-intrinsic-apoptosis-in-human-skin-melanoma-a375-and-squamous-cell-carcinoma-a431-cells
#17
Tae-Ho Kang, Goo Yoon, In-A Kang, Ha-Na Oh, Jung-Il Chae, Jung-Hyun Shim
Licochalcone B (Lico B), which is normally isolated from the roots of Glycyrrhiza inflata (Chinese Licorice), generally classified into organic compounds including retrochalcones. Potential pharmacological properties of Lico B include anti-inflammatory, anti-bacterial, anti-oxidant, and anti-cancer activities. However, its biological effects on melanoma and squamous cell carcinoma (SCC) are unknown. Based on these known facts, this study investigated the role of Lico B in apoptosis, through the extrinsic and intrinsic pathways and additional regulation of specificity protein 1 in human skin cancer cell lines...
October 13, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29027278/current-status-of-herbal-drug-standards-in-the-indian-pharmacopoeia
#18
REVIEW
Jai Prakash, Sushma Srivastava, R S Ray, Neha Singh, Roshni Rajpali, Gyanendra Nath Singh
The benefits of herbal drugs were well understood way back. They have been used for the promotion of health and medical purposes - in disease conditions. It is a conventional belief that herbal drugs have no side effects, are cheaper and locally available. Among Indian systems of medicines, herbs/herbal formulations are used to a larger extent. The quality control of the marketed herbs/herbal formulations is important for acquiring optimum therapeutic benefit as well as for expanding global outreach. Therefore, herbal drug standards are important...
October 13, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29027276/natural-medicines-for-acute-renal-failure-a-review
#19
REVIEW
Motahareh Boozari, Hossein Hosseinzadeh
Acute renal failure (ARF) is a life-threating disease with high mortality percentage. Two important mechanisms of ARF are inflammation and oxidative stress. Plants are rich source of antioxidant compounds and have a strong anti-inflammatory activity, so they may be useful for the treatment of ARF. Some herbal medicines are effective against different models of experimentally induced ARF such as cisplatin, gentamicin, glycerol, and ischemia-reperfusion injury. Some of these plants such as ginseng, black seed, ginger, garlic, grape, pomegranate, saffron, and green tea are so famous and are effective against various models of ARF...
October 13, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29027274/comparative-oral-absorption-of-curcumin-in-a-natural-turmeric-matrix-with-two-other-curcumin-formulations-an-open-label-parallel-arm-study
#20
Sreeraj Gopi, Joby Jacob, Karthik Varma, Shintu Jude, Augustine Amalraj, C A Arundhathy, Robin George, T R Sreeraj, C Divya, Ajaikumar B Kunnumakkara, Sidney J Stohs
Curcuminoids are the major bioactive molecules in turmeric, and poor bioavailability deters them from being the major components of many health and wellness applications. This study was conducted to assess the bioavailability of a completely natural turmeric matrix formulation (CNTMF) and compare its bioavailability with two other commercially available formulations, namely, curcumin with volatile oil (volatile oil formulation) and curcumin with phospholipids and cellulose (phospholipid formulation) in healthy human adult male subjects (15 each group) under fasting conditions...
October 13, 2017: Phytotherapy Research: PTR
journal
journal
30069
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"