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Phytotherapy Research: PTR

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https://www.readbyqxmd.com/read/28102026/piperine-a-pungent-alkaloid-from-black-pepper-inhibits-b-lymphocyte-activation-and-effector-functions
#1
David A Soutar, Carolyn D Doucette, Robert S Liwski, David W Hoskin
Piperine has several well-documented anti-inflammatory properties; however, little is known regarding its effect on humoral immunity. In this study, we describe the immunosuppressive effect of piperine on B lymphocytes, which are integral to the humoral immune response. Mouse B cells were cultured in the absence or presence of non-cytotoxic concentrations (25, 50, and 100 μM) of piperine during T-dependent or T-independent stimulation. Piperine inhibited B cell proliferation by causing G0/G1 phase cell cycle arrest in association with reduced expression of cyclin D2 and D3...
January 19, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/28102022/the-flavonoid-7-4-dihydroxyflavone-prevents-dexamethasone-paradoxical-adverse-effect-on-eotaxin-production-by-human-fibroblasts
#2
Changda Liu, Nan Yang, Xiaoke Chen, Jody Tversky, Jixun Zhan, Mirna Chehade, Rachel L Miller, Xiu-Min Li
Eotaxin/CCL-11 is a major chemoattractant that contributes to eosinophilic inflammation in asthma. Glucocorticoids inhibit inflammation, but long-time exposure may cause paradoxical adverse effects by augmenting eotaxin/CCL-11production. The aim of this study was to determine if 7,4'-dihydroxyflavone (7,4'-DHF), the eotaxin/CCL11 inhibitor isolated from Glycyrrhiza uralensis, reduces in vitro eotaxin production induced by long-time dexamethasone (Dex) exposure, and if so, to elucidate the mechanisms of this inhibition...
January 19, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/28093828/a-systematic-review-on-ethnomedicines-of-anti-cancer-plants
#3
REVIEW
Akash Tariq, Sehrish Sadia, Kaiwen Pan, Ihteram Ullah, Sakina Mussarat, Feng Sun, Olatunji Olusanya Abiodun, Altanzagas Batbaatar, Zilong Li, Dagang Song, Qinli Xiong, Riaz Ullah, Suliman Khan, Buddha Bahadur Basnet, Brawin Kumar, Rabiul Islam, Muhammad Adnan
Cancer is a serious health problem and the second leading cause of death around the globe. Present review is an attempt to provide utmost information based on ethno-pharmacological and toxicological aspects of anti-cancer plants of the world. A total of 276 articles published in English journals and containing maximum ethnomedicinal information were reviewed using several data sources such as; Google scholar, Web of Science, Scopus, PubMed and floras of different countries. A total of 199 anti-cancer plants were recorded in present review and results indicated that traditional medicines are mostly being use in developing countries for cancer treatment...
January 17, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/28093815/nigella-sativa-supplementation-improves-asthma-control-and-biomarkers-a-randomized-double-blind-placebo-controlled-trial
#4
Abdulrahman Koshak, Li Wei, Emad Koshak, Siraj Wali, Omer Alamoudi, Abdulrahman Demerdash, Majdy Qutub, Peter Natesan Pushparaj, Michael Heinrich
Poor compliance with conventional asthma medications remains a major problem in achieving asthma control. Nigella sativa oil (NSO) is used traditionally for many inflammatory conditions such as asthma. We aimed to investigate the benefits of NSO supplementation on clinical and inflammatory parameters of asthma. NSO capsules 500 mg twice daily for 4 weeks were used as a supplementary treatment in a randomized, double-blind, placebo-controlled trial in asthmatics (clinicaltrials.gov: NCT02407262). The primary outcome was Asthma Control Test score...
January 17, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/28093813/nerolidol-protects-against-lps-induced-acute-kidney-injury-via-inhibiting-tlr4-nf-%C3%AE%C2%BAb-signaling
#5
Lu Zhang, Dandan Sun, Yan Bao, Yan Shi, Yan Cui, Minghao Guo
Acute kidney injury (AKI) is a critical care syndrome, resulting in acute reduction of renal function and up to 22% mortality of hospitalized patients. Nerolidol is a major component in several essential oils that possesses various pharmacological properties. The present study aimed to investigate the potential effect of nerolidol on lipopolysaccharide (LPS)-induced AKI. Nerolidol dose-dependently reduced the pathological injuries of kidney induced by LPS in rats. Nerolidol significantly decreased the levels of blood urea nitrogen and creatinine in LPS-treated rats in a dose-dependent manner...
January 17, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/28084039/experimental-and-clinical-pharmacology-of-ziziphus-jujuba-mills
#6
REVIEW
Javier Rodríguez Villanueva, Laura Rodríguez Villanueva
Ziziphus jujuba Mills, 'annab' in Iran, 'ber' in India or 'pomme sourette' in France, is a species whose fruit (known warmly as 'the fruits of life' in China) has been consumed for centuries for its nutritional value. The food industry used it as a food additive and flavoring. The dry seeds, the crude leaves and the stem bark are still used in ethnopharmacology to treat digestive disorders and gastric ulcers as antitussive, laxative and hypotensive drugs; even now, it is used in China to treat children who suffer from typhoid fever, furuncle and ecthyma...
January 13, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/28083890/amhezole-a-novel-fungal-secondary-metabolite-from-aspergillus-terreus-for-treatment-of-microbial-mouth-infection
#7
Amani S Awaad, Hind A Al-Mudhayyif, Monerah R Al-Othman, Mohamed E Zain, Reham M El-Meligy
Bio-guided fractionation of Aspergillus terreus extract leads to isolation of a novel terpenoidal secondary metabolite. The isolated compound and the total alcoholic extract of Aspergillus terreus showed a remarkable activity against microbial mouth infections; namely, Candida albicans, Lactobacillus acidophilus, Streptococcus gordonii, and S. mutan. Moreover, the Minimum Inhibitory Concentration of the isolated compound was determined and showed low values. The combination of each of the alcoholic extract of A...
January 13, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/28078812/gentiana-scabra-bunge-formula-for-herpes-zoster-biological-actions-of-key-herbs-and-systematic-review-of-efficacy-and-safety
#8
REVIEW
Kaiyi Wang, Meaghan E Coyle, Suzi Mansu, Anthony Lin Zhang, Charlie Changli Xue
This study reviewed the biological action of key herbs and evaluated systematically the efficacy and safety of oral Gentiana formula for herpes zoster (HZ). Experimental studies relevant to HZ were identified in PubMed. Randomized controlled trials using Gentiana formula for HZ were identified from nine English and Chinese databases. The primary outcome was evaluation of pain. Potential risk of bias was assessed. Meta-analysis was conducted using mean difference or risk ratio with 95% confidence intervals. Key herbs Gentiana scabra Bunge, Gentiana triflora Pall, Scutellaria baicalensis Georgi, and Gardenia jasminoides Ellis have shown antiinflammatory actions through inhibition of inflammatory cytokines and pro-inflammatory enzymes...
January 12, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/28078810/anti-hcv-activity-from-semi-purified-methanolic-root-extracts-of-valeriana-wallichii
#9
Krishna Kumar Ganta, Anirban Mandal, Sukalyani Debnath, Banasri Hazra, Binay Chaubey
Hepatitis C virus (HCV) is a serious global health problem affecting approximately 130-150 million individuals. Presently available direct-acting anti-HCV drugs have higher barriers to resistance and also improved success rate; however, cost concerns limit their utilization, especially in developing countries like India. Therefore, development of additional agents to combat HCV infection is needed. In the present study, we have evaluated anti-HCV potential of water, chloroform, and methanol extracts from roots of Valeriana wallichii, a traditional Indian medicinal plant...
January 12, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/28070931/anti-rheumatoid-arthritis-effect-of-kaejadan-via-analgesic-and-antiinflammatory-activity-in-vivo-and-in-vitro
#10
Jung Jae Yoon, Eun Jung Sohn, Jung Hyo Kim, Jai Wha Seo, Sung-Hoon Kim
Although Kaejadan (KJD), an herbal cocktail of three medicinal plants (Lithospermum erythrorhizon, Cinnamomum loureirii, and Salvia miltiorrhiza), has been traditionally used for the treatment of rheumatoid arthritis, its scientific evidence is not fully understood. Hence, we investigated antiinflammatory and analgesic mechanism of KJD in vivo and in vitro. Kaejadan suppressed the number of writhing responses in mice treated by acetic acid and showed antinociceptive effect by tail-flick test. Kaejadan abrogated serotonin or carrageenan or Freund's complete adjuvant (FCA)-induced paw edema and also reduced the level of Evans Blue for vascular permeability...
January 9, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/27991703/risk-assessment-via-metabolism-and-cell-growth-inhibition-in-a-hepg2-c3a-cell-line-upon-treatment-with-arpadol-and-its-active-component-harpagoside
#11
Bruna Isabela Biazi, Gláucia Fernanda Rocha D'Epiro, Thalita Alves Zanetti, Marcelo Tempesta de Oliveira, Lucia Regina Ribeiro, Mário Sérgio Mantovani
Harpagophytum procumbens (Hp) has been used as antiinflammatory and analgesic agent for the treatment of rheumatic diseases. The principal active component of Hp is harpagoside (HA). We tested the toxicity of this new therapeutic agent in a hepatic cell line (HepG2/C3A). Hp was found to be cytotoxic, and HA was found to decrease the number of cells in S phase, increase the number of cells in G2/M phase and induce apoptosis. Neither Hp nor HA was genotoxic. The expression of CDK6 and CTP3A4 was reduced by Hp, and both HA and Hp caused a significant reduction of CYP1A2 and CYP3A4 expression...
December 19, 2016: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/27981642/ginseng-protein-reverses-amyloid-beta-peptide-and-h2-o2-cytotoxicity-in-neurons-and-ameliorates-cognitive-impairment-in-ad-rats-induced-by-a-combination-of-d-galactose-and-alcl3
#12
Hongyan Li, Jie Song, Jianghua Zhang, Tianmin Wang, Yuhui Yan, Zhenyu Tao, Shaoheng Li, Hui Zhang, Tingguo Kang, Jingxian Yang
Ginseng (Panax ginseng C.A. Meyer) is one of the most widely used herbal medicines worldwide. The present study evaluated the neuroprotective effects of ginseng protein (GP) and its possible mechanisms in a cellular and animal model of AD. The results demonstrated that GP (10-100 µg/mL) significantly improved the survival rate of neurons and reduced the cells' apoptosis and the mRNA expression of caspase-3 and Bax/Bcl-2. In addition, GP (0.1 g/kg) significantly shortened the escape latency, prolonged the crossing times and the percentage of residence time; reduced the level of Aβ1-42 and p-tau, the activity of T-NOS and iNOS, and the content of MDA and NO, improved the activity of SOD, the concentration of cAMP and the protein expression of p-PKA/PKA and -CREB/CREB...
December 16, 2016: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/27958644/effect-of-perilla-frutescens-extracts-on-porcine-jejunal-epithelial-cells
#13
Christine M Kaufmann, Thomas Letzel, Johanna Grassmann, Michael W Pfaffl
Green-leaved Perilla frutescens extracts were investigated on their effect on cell proliferation of the porcine jejunal epithelial cell line, IPEC-J2, as well as on the gene expression of cell cycle or cancer-related genes. Some extracted compounds were, however, susceptible to degradation in cell culture medium, whereas others were found to be stable during the entire experimental time. Control experiments also included the assessment of H2 O2 generation in cell culture medium caused by oxidation of natural extract compounds, which was proved to be absent at low extract concentrations...
December 13, 2016: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/27910195/mulberrofuran-g-protects-ischemic-injury-induced-cell-death-via-inhibition-of-nox4-mediated-ros-generation-and-er-stress
#14
Sungeun Hong, Jaeyoung Kwon, Dong-Woo Kim, Hak Ju Lee, Dongho Lee, Woongchon Mar
The aim of this study was to investigate the neuroprotective effect of mulberrofuran G (MG) in in vitro and in vivo models of cerebral ischemia. MG was isolated from the root bark of Morus bombycis. MG inhibited nicotinamide adenine dinucleotide phosphate oxidase (NOX) enzyme activity and oxygen-glucose deprivation/reoxygenation (OGD/R)-induced NOX4 protein expression in SH-SY5Y cells. MG inhibited the expression of activated caspase-3 and caspase-9 and cleaved poly adenine dinucleotide phosphate-ribose polymerase in OGD/R-induced SH-SY5Y cells...
December 2, 2016: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/27910140/side-effects-of-irinotecan-cpt-11-the-clinically-used-drug-for-colon-cancer-therapy-are-eliminated-in-experimental-animals-treated-with-latex-proteins-from-calotropis-procera-apocynaceae
#15
Nylane Maria Nunes de Alencar, Flávio da Silveira Bitencourt, Ingrid Samantha Tavares de Figueiredo, Patrícia Bastos Luz, Roberto César P Lima-Júnior, Karoline Sabóia Aragão, Pedro Jorge Caldas Magalhães, Gerly Anne de Castro Brito, Ronaldo Albuquerque Ribeiro, Ana Paula Fragoso de Freitas, Marcio Viana Ramos
Intestinal mucositis (IM) is the critical side effect of irinotecan (CPT-11), which is the front-line drug used for the treatment of colorectal cancer. This study aimed to evaluate the effectiveness of latex proteins (LP) from Calotropis procera to prevent IM and diarrhea in animals. Swiss mice were treated daily with saline or LP (1, 5, or 50 mg/kg, i.v.) 24 h prior to CTP-11 (75 mg/kg/4 days, i.p) and for additional 6 days. Animal survival, body weight variation, and diarrhea were registered. After animal sacrifice (day 7 post first injection of CPT-11), intestinal samples were collected to study morphology and inflammatory parameters...
December 2, 2016: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/27896922/-epigallocatechin-3-gallate-antihyperalgesic-effect-associates-with-reduced-cx3cl1-chemokine-expression-in-spinal-cord
#16
Marc Bosch-Mola, Judit Homs, Beltrán Álvarez-Pérez, Teresa Puig, Francisco Reina, Enrique Verdú, Pere Boadas-Vaello
(-)-Epigallocatechin-3-gallate (EGCG) is a major polyphenol in green tea with beneficial effects on the neuropathic pain alleviation in animal models. Because chemokine fractalkine (CX3CL1) has been suggested as an important signal during neuropathic pain development, this study aimed to investigate whether CX3CL1 expression may be modulated by EGCG treatment reducing hyperalgesia in chronic constriction injured mice. To this end, Balb/c mice were subjected to a chronic constriction injury of sciatic nerve (CCI) and treated with EGCG or vehicle once a day during the first week following surgery...
November 29, 2016: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/27896890/diterpenes-as-lead-molecules-against-neglected-tropical-diseases
#17
REVIEW
Marcus Vinícius Oliveira Barros de Alencar, João Marcelo de Castro E Sousa, Hercília Maria Lins Rolim, Maria das Graças Freire de Medeiros, Gilberto Santos Cerqueira, Fernanda Regina de Castro Almeida, Antônia Maria das Graças Lopes Citó, Paulo Michel Pinheiro Ferreira, José Arimatéia Dantas Lopes, Ana Amélia de Carvalho Melo-Cavalcante, Md Torequl Islam
Nowadays, neglected tropical diseases (NTDs) are reported to be present everywhere. Poor and developing areas in the world have received great attention to NTDs. Drug resistance, safety profile, and various challenges stimulate the search for alternative medications. Plant-based drugs are viewed with great interest, as they are believed to be devoid of side effects. Diterpenes, a family of essential oils, have showed attractive biological effects. A systematic review of the literature was carried out to summarize available evidences of diterpenes against NTDs...
November 29, 2016: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/27896877/flavonoids-of-herba-epimedii-enhances-bone-repair-in-a-rabbit-model-of-chronic-osteomyelitis-during-post-infection-treatment-and-stimulates-osteoblast-proliferation-in-vitro
#18
Dan Shou, Yang Zhang, Lifeng Shen, Rongzong Zheng, Xiaowen Huang, Zhujun Mao, Zhongming Yu, Nani Wang, Yan Zhu
Flavonoids are the active component of the Herba Epimedii (H. Epimedii), which is commonly used in Asia. This study is to investigate the effect of H. Epimedii on bone repair after anti-infection treatment in vivo. The bioactive-composition group of H. Epimedii (BCGE) contained four flavonoids with the total content of 43.34%. Rabbits with chronic osteomyelitis in response to injection with Staphylococcus aureus were treated with BCGE of 242.70 mg/kg/day intragastrically after vancomycin-calcium sulphate treatment...
November 29, 2016: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/27878888/metabolomics-reveals-that-momordica-charantia-attenuates-metabolic-changes-in-experimental-obesity
#19
Zhi-Gang Gong, Jianbing Zhang, Yong-Jiang Xu
Momordica charantia L., also known as bitter melon, has been shown to ameliorate obesity and insulin resistance. However, metabolic changes regulated by M. charantia in obesity are not clearly understood. In this study, serums obtained from obese and M. charantia-treated mice were analyzed by using gas and liquid chromatography-mass spectrometry, and multivariate statistical analysis was performed by Orthogonal partial least squares discriminant analysis. The results from this study indicated that body weight fat and insulin levels of obese mice are dramatically suppressed by 8 weeks of dietary supplementation of M...
November 23, 2016: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/27859734/withanolides-against-tlr4-activated-innate-inflammatory-signalling-pathways-a-comparative-computational-and-experimental-study
#20
Preethi M Purushotham, Jin-Man Kim, Eun-Kyeong Jo, Kalaiselvi Senthil
Innate inflammations are dominant causes of poor health and high mortality. The pathogen-associated molecular pattern and lipopolysaccharide (LPS) are sensed by immune cells through activation of toll-like receptor 4 leading to mitogen-activated protein kinases (MAPKs) and NF-κB activations. Controlled MAPK and Nf-κB inhibitors have been proposed as potential antiinflammatory drugs. Withania somnifera is an important medicinal herb with known antiinflammatory activity. In this study, the selected Withania somnifera extracts and withanolides were analysed on LPS-induced macrophages comparatively...
November 17, 2016: Phytotherapy Research: PTR
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