journal
MENU ▼
Read by QxMD icon Read
search

Phytotherapy Research: PTR

journal
https://www.readbyqxmd.com/read/28639379/the-in-vitro-and-in-vivo-biological-activities-of-the-leaf-of-cape-myrtle-myrsine-africana-l
#1
Hina Gul, Mushtaq Ahmad, Muhammad Zafar, M Shareez Ahmad, AmbreenAbid, Syeda Hira, Imam Shah, Muhammad Gulfraz
The cape myrtle, Myrsine africana L., is a widely used medicinal plant, which has not been well investigated. We assessed the in vivo hepatoprotective and in vitro antiproliferative and antioxidant effects of leaf extracts of M. africana chemically profiled using high-performance liquid chromatography. Three flavonoids were quantified, and gas chromatography-mass spectrometry analysis revealed the presence of common fatty acids. The animal study was conducted on mice treated with CCl4, using three doses each of the methanol and chloroform extract (100, 200 and 300 mg/kg b...
June 22, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/28639266/bakuchiol-contributes-to-the-hepatotoxicity-of-psoralea-corylifolia-in-rats
#2
Zhi-Jian Li, Abudumijiti Abulizi, Guo-Lin Zhao, Tao Wang, Fan Zhou, Zhen-Zhou Jiang, Silafu Aibai, Lu-Yong Zhang
Psoralea corylifolia L. (Fructus Psoraleae) is widely used in Asia, but there are concerns about hepatotoxicity caused by constituents such as psoralens and bakukiol. Bakuchiol (BAK) has antiinflammatory, antipyretic, antibacterial antiviral, anticancer, and estrogenic activity but appears to be hepatotoxic in in vitro tests. This study investigated the hepatotoxicity in vivo in rats. Using intragastrically administered bakuchiol at doses of 52.5 and 262.5 mg/kg for 6 weeks. Bodyweight, relative liver weight, biochemical indicators, histopathology, mRNA expression of CYP7A1, HMG-CoA reductase, BSEP, PPARα, SREBP-2, and MRP3 were measured...
June 22, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/28635153/topical-silymarin-administration-for-prevention-of-capecitabine-induced-hand-foot-syndrome-a-randomized-double-blinded-placebo-controlled-clinical-trial
#3
Sepideh Elyasi, Farzaneh Sadat Rezazadeh Shojaee, Abolghasem Allahyari, Gholamreza Karimi
Hand-foot syndrome (HFS) is a frequent dose-limiting adverse reaction of capecitabine in patient with gastrointestinal cancers. Silymarin is a polyphenolic flavonoid extracted from the Silybum marianum that exhibits strong antioxidant and antiinflammatory activities. In this study, we evaluated silymarin efficacy in prevention of capecitabine-induced HFS in patients with gastrointestinal cancers, as the first human study. During this pilot, randomized, double-blinded, placebo-controlled clinical trial, the effect of silymarin gel 1%, which is applied on the palms and soles twice daily starting at the first day of chemotherapy for 9 weeks, on HFS occurrence was assessed...
June 21, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/28635142/protective-effects-induced-by-microwave-assisted-aqueous-harpagophytum-extract-on-rat-cortex-synaptosomes-challenged-with-amyloid-%C3%AE-peptide
#4
Claudio Ferrante, Lucia Recinella, Marcello Locatelli, Paolo Guglielmi, Daniela Secci, Lidia Leporini, Annalisa Chiavaroli, Sheila Leone, Sara Martinotti, Luigi Brunetti, Michele Vacca, Luigi Menghini, Giustino Orlando
Harpagophytum procumbens is a plant species that displays anti-inflammatory properties in multiple tissues. The iridoid glycosides arpagoside, harpagide, and procumbide appear to be the most therapeutically important constituents. In addition, harpagoside treatment exerted neuroprotective effects both in vitro and in vivo. Considering these findings, the aim of the present work is to explore the possible protective role of the previously described microwave-assisted aqueous extract of H. procumbens on rat hypothalamic (Hypo-E22) cells, and in rat cortex challenged with amyloid β-peptide (1-40)...
June 21, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/28635070/adjuvant-treatment-with-qilin-pill-for-men-with-oligoasthenospermia-a-meta-analysis-of-randomized-controlled-trials
#5
REVIEW
Xin Jin, Changfeng Man, Dandan Gong, Yu Fan
Qilin pill has been used in the management of oligoasthenospermia. This meta-analysis aimed to evaluate the effects of Qilin pill as an adjunctive therapy on semen parameters in oligoasthenospermic men. A comprehensive literature search was conducted in PubMed, Embase, Cochrane Library, Wanfang, CNKI, and VIP databases until June 2016. Randomized controlled trials (RCTs) that evaluated Qilin pill as an adjunctive therapy in oligoasthenospermic were included. Dichotomous data and continuous data were calculated as the risk ratio (RR) and mean difference (MD) with their 95% confidence interval (CI), respectively...
June 21, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/28631356/immune-tolerance-effect-in-mesenteric-lymph-node-lymphocytes-of-geniposide-on-adjuvant-arthritis-rats
#6
Zheng-Rong Zhang, Hong Wu, Rong Wang, Shu-Ping Li, Li Dai, Wen-Yu Wang
Rheumatoid arthritis (RA) is a systemic, Th1 cytokine-predominant autoimmune disease result in a chronic and inflammatory disorder. Geniposide (GE), an iridoid glycoside compound that is purified from Gardenia jasminoides Ellis, has antiinflammatory and other immunoregulatory effects, but its exact mechanism of actions on RA is unknown. The aim of this study was to elucidate antiinflammation effects of GE on adjuvant arthritis (AA) rats and its possible immune tolerance mechanisms. Male Sprague-Dawley rats were administered with GE (30, 60, and 120 mg/kg) orally from day 17 to 24 after immunization...
June 19, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/28627722/pterostilbene-inhibits-lipogenic-activity-similar-to-resveratrol-or-caffeine-but-differently-modulates-lipolysis-in-adipocytes
#7
Saioa Gomez-Zorita, Chloé Belles, Anaïs Briot, Alfredo Fernández-Quintela, Maria P Portillo, Christian Carpéné
The anti-obesity effects of resveratrol shown in rodents are not transposed into an efficient therapy of human obesity. Consequently, the search for molecules mimicking or surpassing resveratrol actions is ongoing. The natural phenolic compound pterostilbene exhibits beneficial health effects and has the capacity to limit fat mass in animal models. In this study, we tested whether pterostilbene modulates triacylglycerol accumulation/breakdown. Prolonged exposure to pterostilbene or resveratrol inhibited adipocyte differentiation in 3T3-F442A preadipocytes...
June 19, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/28620995/effects-of-tilianin-on-proliferation-migration-and-tgf-%C3%AE-smad-signaling-in-rat-vascular-smooth-muscle-cells-induced-with-angiotensin-ii
#8
Wenjiang Cao, Na Hu, Yong Yuan, Jiang Cheng, Xinhong Guo, Yanfang Wang, Xinchun Wang, Ping Hu
Flavonoid Tilianin was isolated from Dracocephalum moldavica, and its pharmacological mechanism on proliferation, migration and the TGF-β/Smad signaling pathway in rat vascular smooth muscle cells (VSMCs) induced with Angiotensin II (Ang II) was systematically evaluated. Primary rat VSMCs were stimulated with Ang II to induce proliferation. The cells were then treated with Tilianin for 24 or 48 h. MTT assay and Transwell assays were used to evaluate the effects of Tilianin on proliferation and migration. The expression of intracellular proliferating cell nuclear antigen (PCNA), intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) were measured by immunohistochemistry as verification of effects on proliferation and migration...
June 16, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/28618131/pharmacognosy-phytochemistry-and-pharmacological-properties-of-achillea-millefolium-l-a-review
#9
REVIEW
Sofi Imtiyaz Ali, B Gopalakrishnan, V Venkatesalu
Achillea millefoilum L. (Yarrow) is an important species of Asteraceae family with common utilization in traditional medicine of several cultures from Europe to Asia for the treatment of spasmodic gastrointestinal disorders, hepatobiliary, gynecological disorders, against inflammation and for wound healing. An extensive review of literature was made on A. millefoilum L. using ethno botanical text books, published articles in peer-reviewed journals, unpublished materials and scientific databases. The Plant List, International Plant Name Index and Kew Botanical Garden databases were used to authenticate the scientific names...
June 15, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/28618070/morin-suppresses-astrocyte-activation-and-regulates-cytokine-release-in-bone-cancer-pain-rat-models
#10
Wei Jiang, Ying Wang, Wei Sun, Mengyuan Zhang
As inflammatory and immune responses are involved in pathophysiology of debilitating neuropathic pain, reagents that can modulate these two responses may have therapeutic potential. Morin, derived from the moraceae family of plants, benefits inflammation-related diseases, but its antinociceptive effects on cancer pain remain elusive. In the present study, we investigated antinociceptive effects of morin on bone cancer pain using a rat model, where rats were subject to implantation of Walker 256 mammary gland carcinoma cells into the tibia...
June 15, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/28593720/phytoestrogen-rich-natural-preparation-for-treatment-of-climacteric-syndrome-and-atherosclerosis-prevention-in-perimenopausal-women
#11
T V Kirichenko, V A Myasoedova, V A Orekhova, A L Ravani, N A Nikitina, A V Grechko, I A Sobenin, A N Orekhov
The present study evaluated the risks and benefits of phytoestrogen treatment in healthy perimenopausal women in relation to the dynamics of climacteric syndrome and progression of atherosclerosis. Study participants were treated with placebo or phytoestrogen-rich natural preparation Karinat based on grape (Vitis vinifera) seeds, green tea (Camellia sinensis) leaves, hop (Hunulus lupulus) cone powder and garlic (Allium sativum) powder. The dynamics of climacteric syndrome was evaluated by Kupperman Index and Utian Quality of Life Scale...
June 8, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/28585748/effects-of-curcumin-on-tobacco-smoke-induced-hepatic-mapk-pathway-activation-and-epithelial-mesenchymal-transition-in-vivo
#12
Zhaofeng Liang, Rui Wu, Wei Xie, Chunfeng Xie, Jieshu Wu, Shanshan Geng, Xiaoting Li, Mingming Zhu, Weiwei Zhu, Jianyun Zhu, Cong Huang, Xiao Ma, Wenrong Xu, Caiyun Zhong, Hongyu Han
Tobacco smoke is a major risk factor for hepatic cancer. Epithelial-mesenchymal transition (EMT) induced by tobacco smoke is crucially involved in the initiation and development of cancer. Mitogen-activated protein kinase (MAPK) pathways play important roles in tobacco smoke-associated carcinogenesis including EMT process. The chemopreventive effect of curcumin supplementation against cancers has been reported. In this study, we investigated the effects of tobacco smoke on MAPK pathway activation and EMT alterations, and then the preventive effect of curcumin was examined in the liver of BALB/c mice...
June 6, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/28585735/a-randomized-double-blind-placebo-controlled-clinical-trial-examining-the-effects-of-green-tea-extract-on-systemic-lupus-erythematosus-disease-activity-and-quality-of-life
#13
Z Shamekhi, R Amani, Z Habibagahi, F Namjoyan, Ata Ghadiri, A Saki Malehi
Antiinflammatory and immunomodulatory benefit of green tea (Camellia sinensis) in autoimmune disease has been proven in recent studies. The objective of this study was to assess the effects of green tea on disease activity and quality of life in systemic lupus erythematosus patients. A randomized controlled trial on subjects with lupus was conducted, and 68 patients in the age range of 39.1 ± 10.3 years and body mass index of 25.7 ± 5.21 kg/m(2) completed the 12-week study. Patients were randomly divided into two groups of intervention (1000 mg green tea extract, two capsules/day) and control (1000 mg of starch, two capsules/day)...
June 6, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/28568647/standardized-passiflora-incarnata-l-extract-reverts-the-analgesia-induced-by-alcohol-withdrawal-in-rats
#14
Rebeca Vargas Antunes Schunck, Isabel Cristina Macedo, Gabriela Laste, Andressa de Souza, Marina Tuerlinckx Costa Valle, Janaína L O Salomón, Ellen Almeida Nunes, Andreia Cristina Wildner Campos, Simone Cristina Baggio Gnoatto, Ana Maria Bergold, Eduardo L Konrath, Eliane Dallegrave, Marcelo Dutra Arbo, Iraci L S Torres, Mirna Bainy Leal
Passiflora incarnata L. (Passifloraceae) has been traditionally used for treatment of anxiety, insomnia, drug addiction, mild infections, and pain. The aim of this study was to investigate the effect of a commercial extract of P. incarnata in the analgesia induced by alcohol withdrawal syndrome in rats. In addition, brain-derived neurotrophic factor and interleukin-10 levels were evaluated in prefrontal cortex, brainstem, and hippocampus. Male adult rats received by oral gavage: (1: water group) water for 19 days, 1 day interval and water (8 days); (2: P...
June 1, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/28568565/inhibition-of-th1-and-th17-cells-by-medicinal-plants-and-their-derivatives-a-systematic-review
#15
REVIEW
Majid Asadi-Samani, Nader Bagheri, Mahmoud Rafieian-Kopaei, Hedayatollah Shirzad
Searching for new natural drugs that are capable of targeting Th1 and Th17 may lead to development of more effective treatments for inflammatory and autoimmune diseases. Most of the natural drugs can be derived from plants that are used in traditional medicine and folk medicine. The aim of this systematic review is to identify and introduce plants or plant derivatives that are effective on inflammatory diseases by inhibiting Th1 and Th17 responses. To achieve this purpose, the search terms herb, herbal medicine, herbal drug, medicinal plant, phytochemical, traditional Chinese medicine, Ayurvedic medicine, natural compound, inflammation, inflammatory diseases, Th1, Th17, T helper 1 or T helper 17 were used separately in Title/Keywords/Abstract in Web of Science and PubMed databases...
June 1, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/28568378/cytotoxic-properties-of-the-stem-bark-of-citrus-reticulata-blanco-rutaceae
#16
Tasmia Tahsin, Jean Duplex Wansi, Afaf Al-Groshi, Andrew Evans, Lutfun Nahar, Claire Martin, Satyajit Dey Sarker
The bioassay-guided fractionation of the n-hexane extract of Citrus reticulata Blanco (Rutaceae) stem bark yielded scoparone (1), xanthyletin (2), lupeol (3), β-amyrin (4), stigmasterol (5), β-sitosterol (6) and palmitic acid. The structures of these compounds were determined by comprehensive spectroscopic analyses, i.e., 1D and 2D NMR and EI-MS, and by comparison with the reported data. Extracts, fractions and isolated compounds 1-6 were assessed for cytotoxicity by the 3-(4,5-dimethylthiazol-2-yl)-2,5-dphenyltetrazolium bromide (MTT) assay against three human cancer cell lines, i...
June 1, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/28557133/pharmacological-and-toxicological-effects-of-catha-edulis-f-khat
#17
REVIEW
Ephrem Engidawork
Khat chewing is deeply rooted in the culture and tradition of communities in khat belt countries, and its consumption is spread to other countries through the suitcase trade. The aim of this article is to review current knowledge on the chemistry, social, pharmacology and toxicology of khat and its use. Khat produces effect invariably in every system, which is harmful or beneficial in some instances. Harmful effects are observed in heavy users, although firm evidence is lacking. Chewing khat acutely elicits states of euphoria, which is followed by low mood...
May 30, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/28557048/elucidation-of-compatibility-interactions-of-traditional-chinese-medicines-in-vitro-absorptions-across-caco-2-monolayer-of-coptidis-rhizoma-and-euodiae-fructus-in-zuojin-and-fanzuojin-formulas-as-a-case
#18
Yan-Fang Yang, Qi-Le Zhou, Xiu-Wei Yang
Traditional Chinese medicines are often combined as formulae and interact with each other. As for Coptidis Rhizoma (CR) and Euodiae Fructus (EF), the most classical compatibilities were Zuojin (ZJF) and Fanzuojin formulas (FZJF) with reverse mixture ratios and opposite effects. To compare in vitro absorption interactions between CR and EF, bidirectional transports across Caco-2 cell monolayer of extracts of two formulas and equivalent single herbs were studied. Eighteen alkaloids from CR and EF were determined by liquid chromatography coupled to tandem mass spectrometry...
May 30, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/28544187/chemical-composition-and-immuno-modulatory-effects-of-urtica-dioica-l-stinging-nettle-extracts
#19
Marina Francišković, Raquel Gonzalez-Pérez, Dejan Orčić, Fermín Sánchez de Medina, Olga Martínez-Augustin, Emilija Svirčev, Nataša Simin, Neda Mimica-Dukić
The purpose of this work was to determine the chemical profile of stinging nettle and to provide an insight into the mechanisms by which it ameliorates the immune response. Qualitative and quantitative liquid chromatography tandem mass spectrometry analyses indicated that phenolic acids (5-O-caffeoylquinic acid as dominant) and flavonol glycosides (rutin, isoquercitrin, and kaempferol 3-O-glucoside) are present in the aerial parts, while lignans (secoisolariciresinol, 9,9'-bisacetyl-neo-olivil and their glucosides) were detected in the root...
May 24, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/28543910/wheatgrass-derived-polysaccharide-has-antiinflammatory-anti-oxidative-and-anti-apoptotic-effects-on-lps-induced-hepatic-injury-in-mice
#20
Sarmila Nepali, Hyeon-Hui Ki, Ji-Hyun Lee, Hoon-Yeon Lee, Dae-Ki Kim, Young-Mi Lee
Hepatic injury occurs frequently during sepsis, and polysaccharides isolated from plants have been reported to have antiinflammatory and antioxidant effects in various models. However, the effect of wheatgrass-derived polysaccharide (WGP) has not been previously studied. In the present study, we investigated the effect of WGP on lipopolysaccharide (LPS)-induced hepatic injury in mice. Mice were pre-treated with WGP (100 or 200 mg/kg daily for 2 days) and then challenged with LPS (1 mg/kg, intraperitoneal), and sacrificed after 12 h...
May 24, 2017: Phytotherapy Research: PTR
journal
journal
30069
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"