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Phytotherapy Research: PTR

Xuesheng Han, Cody Beaumont, Damian Rodriguez, Tyler Bahr
Very few studies have investigated the biological activities of black pepper essential oil (BPEO) in human cells. Therefore, in the current study, we examined the biological activities of BPEO in cytokine-stimulated human dermal fibroblasts by analyzing the levels of 17 important protein biomarkers pertinent to inflammation and tissue remodeling. BPEO exhibited significant antiproliferative activity in these skin cells and significantly inhibited the production of Collagen I, Collagen III, and plasminogen activator inhibitor 1...
May 17, 2018: Phytotherapy Research: PTR
Hyeonhoon Lee, Seunghoon Lee, Jung Won Kang, Jae-Dong Lee
Herbal medicines have been used as a treatment option for rheumatic disease (RD), but they often produce liver enzyme abnormality. This study examines the incidence of herb-induced liver injury (HILI) and the relationship between risk factors and liver enzyme abnormality (LEA) in inpatients with RD. HILI was analyzed using the Roussel Uclaf causality assessment method liver injury criteria and causality assessment. Multivariable analysis was performed to assess the relationship between patient characteristics and LEA in RD...
May 16, 2018: Phytotherapy Research: PTR
Mahdi Amiri, Abbasali Nourian, Maryam Khoshkam, Ali Ramazani
Due to the challenges in the control, prevention, and eradication of parasitic diseases like malaria, there is an urgent need to discover new therapeutic agents. Plant-derived medicines may open new ways in the field of antiplasmodial therapy. This study is aimed to investigate the toxicity and in vivo antiplasmodial activity of apigenin, a dietary flavonoid. Apigenin cytotoxicity was investigated on Huh7 cell line, brine shrimp (Artemia salina) larva, and human red blood cells. In vivo toxicity of apigenin was assessed by metabolomics approaches...
May 11, 2018: Phytotherapy Research: PTR
Mehdi Sharifi-Rad, Dima Mnayer, Maria Flaviana Bezerra Morais-Braga, Joara Nályda Pereira Carneiro, Camila Fonseca Bezerra, Henrique Douglas Melo Coutinho, Bahare Salehi, Miquel Martorell, María Del Mar Contreras, Azam Soltani-Nejad, Yoshie Adriana Hata Uribe, Zubaida Yousaf, Marcello Iriti, Javad Sharifi-Rad
The genus Echinacea consists of 11 taxa of herbaceous and perennial flowering plants. In particular, Echinacea purpurea (L.) Moench is widely cultivated all over the United States, Canada, and in Europe, exclusively in Germany, for its beauty and reported medicinal properties. Echinacea extracts have been used traditionally as wound healing to improve the immune system and to treat respiratory symptoms caused by bacterial infections. Echinacea extracts have demonstrated antioxidant and antimicrobial activities, and to be safe...
May 10, 2018: Phytotherapy Research: PTR
ZhengWang Sun, Juan Du, Eunson Hwang, Tae-Hoo Yi
Paeonia suffruticosa Andr. (PS) has been used in traditional Chinese medicine for a long time. However, there are no studies that investigate the preventive effects of PS on ultraviolet B (UVB)-induced photoaging. In this study, paeonol (PA) was detected the main compound in PS root. In vitro, PS and PA significantly inhibited UVB-induced phosphorylation of mitogen-activated protein kinase and activator protein 1 in keratinocytes, which consequently led to degradation of procollagen type I. On the other hand, PS and PA increased NAD(P)H:quinone oxidoreductase 1 and heme oxygenase-1 expression, confirmed by greater nuclear accumulation of nuclear factor E2-releated factor 2 (Nrf2)...
May 10, 2018: Phytotherapy Research: PTR
Mehdi Sharifi-Rad, Elena Maria Varoni, Marcello Iriti, Miquel Martorell, William N Setzer, María Del Mar Contreras, Bahare Salehi, Azam Soltani-Nejad, Sadegh Rajabi, Mercedeh Tajbakhsh, Javad Sharifi-Rad
Carvacrol (CV) is a phenolic monoterpenoid found in essential oils of oregano (Origanum vulgare), thyme (Thymus vulgaris), pepperwort (Lepidium flavum), wild bergamot (Citrus aurantium bergamia), and other plants. Carvacrol possesses a wide range of bioactivities putatively useful for clinical applications such antimicrobial, antioxidant, and anticancer activities. Carvacrol antimicrobial activity is higher than that of other volatile compounds present in essential oils due to the presence of the free hydroxyl group, hydrophobicity, and the phenol moiety...
May 9, 2018: Phytotherapy Research: PTR
Mitsuko Ohashi, Michael Amoa-Bosompem, Kofi Dadzie Kwofie, Jefferey Agyapong, Richard Adegle, Maxwell Mamfe Sakyiamah, Frederick Ayertey, Kofi Baffuor-Awuah Owusu, Isaac Tuffour, Philip Atchoglo, Nguyen Huu Tung, Takuhiro Uto, Frederick Aboagye, Alfred Ampomah Appiah, Regina Appiah-Opong, Alexander K Nyarko, William Kofi Anyan, Irene Ayi, Daniel Adjei Boakye, Kwadwo Ansah Koram, Dominic Edoh, Shoji Yamaoka, Yukihiro Shoyama, Nobuo Ohta
Trypanosomiasis, leishmaniasis, and malaria are protozoan infections of public health importance with thousands of new cases recorded annually. Control of these infection(s) with existing chemotherapy is limited by drug toxicity, lengthy parenteral treatment, affordability, and/or the emergence of resistant strains. Medicinal plants on the other hand are used in the treatment of various infectious diseases although their chemical properties are not fully evaluated. In this study, we screened 112 crude extracts from 72 selected Ghanaian medicinal plants for anti-Trypanosoma, anti-Leishmania, and anti-Plasmodium activities in vitro and investigated their mechanisms of action...
May 7, 2018: Phytotherapy Research: PTR
Jakub Pannek, Joanna Gach, Filip Boratyński, Teresa Olejniczak
Apiaceae plants exhibit a broad spectrum of activities, for instance, antithrombotic, hypotensive, antioxidant, and insecticidal. They also provide a source of phthalides, which display antimicrobial activity. Considering the fact of rising resistance of both bacteria and fungi against commonly used antibiotics, developing of new naturally derived compounds is undeniably attractive approach. To our best knowledge, there are no other reviews concerning this subject in the literature. In view of above, an attempt to summarize an antimicrobial potential of isolated compounds and extracts from Apiaceae plants has been made, by specifying techniques of activity determination and methods of extraction...
May 7, 2018: Phytotherapy Research: PTR
Xiaorui Lin, Nan Zhang
Berberine, an isoquinoline alkaloid, is demonstrated to have a variety of pharmacologic effects. Widely used as nonprescription drug for diarrhea, berberine has also broadened its applications in therapies of cardiovascular diseases, diabetes mellitus, tumor, and so forth. However, researches about berberine's protective effects on nervous system are still so insufficient that clinical uses cannot popularize and underlying molecules mechanisms are confused and incomplete. Well-known pathways such as Pl3K/Akt/Bcl-2 pathway, Nrf2/HO-1 pathway, and MAPK signaling pathway help berberine to protect neurons through antiapoptotic, antioxidative, and anti-inflammatory activities...
May 6, 2018: Phytotherapy Research: PTR
D M González Mosquera, Y Hernández Ortega, P L Fernández, Y González, D Doens, Y Vander Heyden, K Foubert, L Pieters
No abstract text is available yet for this article.
May 3, 2018: Phytotherapy Research: PTR
Jae Hee Lee, Hyo-Jung Lee, Deok Yong Sim, Ji Hoon Jung, Ka Ram Kim, Sung-Hoon Kim
Though lambertianic acid (LA) was known to exert antitumor effect in liver and prostate cancers, its underlying anticancer mechanism is never reported in breast cancers so far. Thus, in this study, apoptotic mechanism of LA was elucidated in MDA-MB-231 breast cancer cells. Here, LA increased cytotoxicity in MCF-7 and MDA-MB-231 cells; enhanced sub-G1 population, G2/M arrest, and cleaved poly(ADP-ribose) polymerase; activated phosphorylation of AMP-activated protein kinase (AMPK)/acetyl-CoA carboxylase pathway; and also suppressed phosphorylation of AKT and the expression of forkhead box M1 (FOXM1), X-linked inhibitor of apoptosis protein, B-cell lymphoma 2, and CyclinB1 in MDA-MB-231 cells...
May 2, 2018: Phytotherapy Research: PTR
Janaína Artem Ataide, Letícia Caramori Cefali, Fernanda Machado Croisfelt, Andréa Arruda Martins Shimojo, Laura Oliveira-Nascimento, Priscila Gava Mazzola
Nature has been a source of medicinal treatments for thousands of years, with the use of plants as prototypes for drug development and for the extraction of active compounds. Skin injuries occur regularly in everyday life, and the human skin has the ability to promote repair spontaneously under healthy conditions. However, some intrinsic and external factors may interfere with skins' natural ability, leading to nonhealing lesions and chronic wounds, which directly affect health and quality of life. Thus, attention should be given to this health problem, using an appropriated management when necessary...
May 2, 2018: Phytotherapy Research: PTR
Catharine Avila, Dawn Whitten, Sue Evans
Herbal products are popular among women during the perinatal period. St John's wort (SJW), Hypericum perforatum, is a common remedy for mild depression, a problem prevalent in this population. Although the safety of herbal products must be investigated, ethical issues constrain intervention studies in humans. Hence, animal studies often inform clinical decisions. The objective of this study is to systematically review rodent studies assessing the safety of SJW during the perinatal period. A literature search to November 10, 2017, identified 10 rodent studies that met a priori inclusion criteria...
April 30, 2018: Phytotherapy Research: PTR
Colin M McGill, Patrick L Tomco, Regina M Ondrasik, Kaitlyn C Belknap, Gaelen K Dwyer, Daniel J Quinlan, Thomas A Kircher, Cheryl P Andam, Timothy J Brown, David F Claxton, Brian M Barth
Acute myeloid leukemia (AML) is an aggressive hematological malignancy that is one of the more common pediatric malignancies in addition to occurring with high incidence in the aging population. Unfortunately, these patient groups are quite sensitive to toxicity from chemotherapy. Northern Labrador tea, or Rhododendron tomentosum Harmaja (a.k.a. Ledum palustre subsp. decumbens) or "tundra tea," is a noteworthy medicinal plant used by indigenous peoples in Alaska, Canada, and Greenland to treat a diversity of ailments...
April 27, 2018: Phytotherapy Research: PTR
Hong Cai, Xiaolin He, Chunhui Yang
Costunolide, a sesquiterpene lactone, is a small molecular monomer extracted from Inula helenium (Compositae). In the present study, we assessed the antileukemia effects of costunolide on the human chronic myeloid leukemia cell line K562 and its combined activity with imatinib. A Cell Counting Kit-8 assay demonstrated that costunolide significantly inhibited K562 cell proliferation and enhanced imatinib-induced anti-proliferative activity. We found that costunolide significantly induced mitochondrial apoptosis in K562 cells by modulating the protein levels of Bcl-2 family members and by inducing caspase activation...
April 27, 2018: Phytotherapy Research: PTR
Yao-Wu Liu, Yun-Chao Hao, Ya-Jing Chen, Shen-Yuan Yin, Meng-Ya Zhang, Li Kong, Tao-Yun Wang
Rhizome of Anemarrhena asphodeloides Bunge (AA, family Liliaceae) has been widely used in China for thousands of years to treat febrile diseases and diabetes. Steroidal saponins from AA show good antidiabetes effects and ameliorate diabetic complications. This study was designed to investigate the effects of sarsasapogenin (Sar), a major sapogenin from AA, on diabetic nephropathy (DN) in rats, and to explore the possible mechanisms. Diabetic rats were divided into 3 groups treated orally with Sar (0, 20, or 60 mg/kg) and carboxymethylcellulose sodium, whereas normal rats for Sar (0 or 60 mg/kg) and carboxymethylcellulose sodium...
April 23, 2018: Phytotherapy Research: PTR
Ki Sun Kwon, Ju Hee Lee, Kyung Su So, Byung Kyu Park, Hyun Lim, Jae Sue Choi, Hyun Pyo Kim
The purpose of the present study is to find the natural compound(s) having a therapeutic potential to treat lung inflammatory disorders. In our screening procedure, the methanol extract of the seeds of Cassia obtusifolia (cassiae semen) inhibited inducible nitric oxide synthase-catalyzed nitric oxide production in alveolar macrophages (MH-S). From the extract, 8 major anthraquinone derivatives were successfully isolated. They are chrysophanol, physcion, 2-hydroxy-emodin 1-methyl ether, obtusifolin, obtusin, aurantio-obtusin, chryso-obtusin, and gluco-obtusifolin, among which aurantio-obtusin (IC50  = 71...
April 20, 2018: Phytotherapy Research: PTR
Marwa Mekni Toujani, Massimo Rittà, Andrea Civra, Salvatore Genovese, Francesco Epifano, Abdeljelil Ghram, David Lembo, Manuela Donalisio
No abstract text is available yet for this article.
April 19, 2018: Phytotherapy Research: PTR
Lianet Monzote, Gerald Geroldinger, Matthias Tonner, Ramón Scull, Sritama De Sarkar, Sophie Bergmann, Markus Bacher, Katrin Staniek, Mitali Chatterjee, Thomas Rosenau, Lars Gille
The antileishmanial activity of the essential oil (EO) from Chenopodium ambrosioides L. has been demonstrated in vitro and in animal models, attributed to the major components of the EO. This study focused on the effects of the three major EO compounds carvacrol, caryophyllene oxide (Caryo), and the antileishmanial endoperoxide ascaridole (Asc) on mitochondrial functions in Leishmania tarentolae promastigotes (LtP). EO and Caryo were able to partially inhibit the leishmanial electron transport chain, whereas other components failed to demonstrate a direct immediate effect...
April 19, 2018: Phytotherapy Research: PTR
Bahare Salehi, Paolo Zucca, Mehdi Sharifi-Rad, Raffaele Pezzani, Sadegh Rajabi, William N Setzer, Elena Maria Varoni, Marcello Iriti, Farzad Kobarfard, Javad Sharifi-Rad
Cancer is a multifactorial disease, and therefore, a multitarget approach is needed to face the complex cancer biology, based on the combined use of different natural and synthetic anticancer agents able to target synergistically multiple signaling pathways involved in carcinogenesis, including angiogenesis and metastasis. In this view, the plant kingdom represents an unlimited source of phytotherapeutics with promising perspectives in the field of anticancer drug discovery. This narrative review aims to provide an updated overview on the bioactive phytochemicals exhibiting a promising potential as adjuvants in conventional anticancer therapies, with emphasis on antiangiogenic and antimetastatic activities...
April 19, 2018: Phytotherapy Research: PTR
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