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Journal of Clinical Dentistry

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https://www.readbyqxmd.com/read/29758155/six-month-evaluation-of-a-sodium-bicarbonate-containing-toothpaste-for-reduction-of-established-gingivitis-a-randomized-usa-based-clinical-trial
#1
Anto Jose, Jonathan Pratten, Mary-Lynn Bosma, Kimberly R Milleman, Jeffery L Milleman, Nan Wang
OBJECTIVES: Short-term use of sodium bicarbonate (NaHCO3)-containing toothpaste reduces plaque and improves clinical measures of gingivitis. To examine this over a longer period, we compared efficacy and tolerability of twice-daily brushing for 24 weeks with 67% or 0% NaHCO3-containing toothpastes in USA-based participants with moderate gingivitis (Clinicaltrials.gov:NCT02207400). METHODS: This was a six-month, randomized, examiner-blind, parallel-group, clinical trial...
March 2018: Journal of Clinical Dentistry
https://www.readbyqxmd.com/read/29758154/an-8-week-clinical-comparison-of-an-oscillating-rotating-electric-rechargeable-toothbrush-and-a-sonic-toothbrush-in-the-reduction-of-gingivitis-and-plaque
#2
Renzo A Ccahuana-Vasquez, Erinn L Conde, Pamela Cunningham, Julie M Grender, C Ram Goyal, Jimmy Qaqish
OBJECTIVES: To evaluate and compare the efficacy of a marketed oscillating-rotating electric rechargeable toothbrush to a marketed sonic toothbrush in the reduction of gingivitis and plaque over an 8-week period. METHODS: This was a randomized, examiner-blind, parallel group, eight-week study. Subjects with presence of mild-to-moderate plaque and gingivitis received an oral examination and were evaluated for baseline gingivitis (Modified Gingival Index; MGI), gingival bleeding (Gingival Bleeding Index; GBI), and plaque (Rustogi Modified Navy Plaque Index)...
March 2018: Journal of Clinical Dentistry
https://www.readbyqxmd.com/read/29758153/an-exploratory-clinical-study-to-monitor-clinical-efficacy-of-an-occluding-technology-dentifrice-in-providing-short-term-relief-from-dentinal-hypersensitivity
#3
Cristina Krause, Nathalie Lunau, Farzana Sufi
OBJECTIVES: To examine dentin hypersensitivity (DH) at multiple time points over a 14-day period in participants who brushed twice daily with a 0.454% SnF2 dentifrice (Test) compared to a 0.76% sodium monofluorophosphate dentifrice with no known anti-sensitivity properties (Control). METHODS: This was a two-week, single-center, randomized, controlled, examiner-blind, two-treatment, parallel-group study in healthy participants with DH. The sensitivity of two selected test teeth and of all sensitive teeth was assessed at baseline and after one, three, seven, 10, and 14 days' treatment in response to evaporative (air) Schiff sensitivity score and visual analogue scale [VAS]) and tactile (tactile threshold) stimuli...
March 2018: Journal of Clinical Dentistry
https://www.readbyqxmd.com/read/29758152/efficacy-of-teeth-whitening-with-a-mouthwash-in-vitro-and-in-vivo-approaches
#4
Franco Gasparri, Bruce Richard Schemehorn, Andrea Zanardi
OBJECTIVES: Two different studies were conducted to evaluate the whitening efficacy of a mouthwash versus a placebo using in vitro and in vivomodels. The tested mouthwash was formulated with no oxidizing or abrasive agents containing chlorhexidine (CHX) and polyvinylpyrrolidone (PVP). METHODS: The purpose of the in vitro study was to determine whether the mouthwash formulation OC15AB could reduce the accumulation of staining in an accepted stain model. Bovine central incisors were cut to obtain enamel specimens of ~8 × 8 mm2...
March 2018: Journal of Clinical Dentistry
https://www.readbyqxmd.com/read/29758151/clinical-effects-of-stabilized-stannous-fluoride-dentifrice-in-reducing-plaque-microbial-virulence-ii-metabonomic-changes
#5
Michael Cannon, Deepa Khambe, Malgorzata Klukowska, David L Ramsey, Melanie Miner, Tom Huggins, Donald J White
OBJECTIVES: The clinical effects of stannous fluoride (SnF2) dentifrice in reducing symptoms of gingivitis and reducing the virulence of subgingival plaque through suppression of activation of gene expression in toll receptor based reporter cells were previously reported. This study expanded analysis of the clinical study to include evaluation of dentifrice effects on salivary metabolites using 1H Nuclear Magnetic Resonance (1H NMR) systems biology-based metabonomics. METHODS: The clinical design was reported previously (J Clin Dent2017;28:16-26)...
March 2018: Journal of Clinical Dentistry
https://www.readbyqxmd.com/read/29334438/in-vitro-and-in-vivo-evaluations-of-the-anticalculus-effect-of-a-novel-stabilized-stannous-fluoride-dentifrice
#6
Tao He, Mary Kay Anastasia, Marianne Zsiska, Teresa Farmer, Eva Schneiderman, Jeffery L Milleman
OBJECTIVES: To evaluate the effect of a novel stannous fluoride dentifrice with zinc citrate on calculus inhibition using both in vitro and clinical models. METHODS: Each investigation tested a novel stabilized 0.454% stannous fluoride dentifrice with zinc citrate as an anticalculus agent (Crest® Pro-Health™ smooth formula) compared to a negative control fluoride dentifrice. The in vitro study used the modified Plaque Growth and Mineralization Model (mPGM). Plaque biofilms were prepared and mineralized by alternate immersion of glass rods in human saliva and artificial mineralization solution...
December 2017: Journal of Clinical Dentistry
https://www.readbyqxmd.com/read/29334437/a-randomized-clinical-trial-to-measure-the-erosion-protection-benefits-of-a-novel-stabilized-stannous-fluoride-dentifrice-versus-a-control-dentifrice
#7
Xinyi Zhao, Tao He, Yanyan He, Cathy Cheng, Haijing Chen
OBJECTIVES: The aim of this investigation was to assess the erosion protection ability of a novel stabilized stannous fluoride (SnF2) dentifrice and a control sodium fluoride dentifrice (NaF) using a well-credentialed human in situ model. METHODS: A novel smooth texture 0.454% stabilized SnF2 dentifrice (Crest® Pro-Health™ smooth formula) and a 0.23% NaF marketed control dentifrice with 5% potassium nitrate (Sensodyne® Pronamel®) were compared in a 10-day, single center, randomized, controlled, double-blind, two-treatment, three-period crossover in situ clinical trial...
December 2017: Journal of Clinical Dentistry
https://www.readbyqxmd.com/read/29334436/assessment-of-the-effects-of-a-novel-stabilized-stannous-fluoride-dentifrice-on-gingivitis-in-a-two-month-positive-controlled-clinical-study
#8
Tao He, Rachelle Eusebio, C R Goyal, Jimmy G Qaqish
OBJECTIVES: The aim of this study was to compare the antibleeding/antigingivitis effectiveness of a newly formulated 0.454% stabilized stannous fluoride dentifrice and a marketed positive control triclosan-containing dentifrice in adults with mild-to-moderate gingivitis. METHODS: This single-center, two-month, randomized and controlled, double-blind, parallel group clinical trial involved adults with preexisting mild-to-moderate gingivitis. Baseline bleeding and gingivitis levels were assessed with the Gingival Bleeding Index (GBI) and Lobene Modified Gingival Index (MGI)...
December 2017: Journal of Clinical Dentistry
https://www.readbyqxmd.com/read/29334435/comparative-antiplaque-effect-of-two-antimicrobial-dentifrices-laboratory-and-clinical-evaluations
#9
Lynn R Friesen, C R Goyal, Jimmy G Qaqish, Tao He, Rachelle Eusebio, Marianne Zsiska, Teresa Farmer, Eva Schneiderman
OBJECTIVES: To compare the effect of a stannous fluoride dentifrice versus a triclosan-containing dentifrice on the reduction of plaque using in vitro and clinical models. METHODS: Both investigations evaluated a novel 0.454% stabilized stannous fluoride dentifrice (Crest® Pro-Health™ smooth formula) versus a sodium fluoride/triclosan positive control dentifrice (Colgate® Total®). The in vitro evaluation utilized the Plaque Glycolysis and Regrowth Model (PGRM), wherein the metabolic effects (acid production/glycolysis inhibition) of the dentifrices were assessed on plaque biofilms grown on glass rods after three days growth and a single dentifrice treatment...
December 2017: Journal of Clinical Dentistry
https://www.readbyqxmd.com/read/29334434/the-case-for-stabilized-stannous-fluoride-dentifrice-an-advanced-formulation-designed-for-patient-preference
#10
Tao He, Svetlana Farrell
Oral diseases, particularly caries and gingivitis, continue to be widespread. Incorporating a stabilized stannous fluoride dentifrice into patients' daily oral hygiene routine is a convenient, cost effective approach to improve and protect their oral health and the appearance of their smile. Unlike other common fluorides that only provide anti-caries benefits (e.g., sodium fluoride and sodium monofluorophosphate), stabilized stannous fluoride formulations have demonstrated broader and significantly greater protection, also reducing plaque, gingivitis, erosion, sensitivity, and halitosis...
December 2017: Journal of Clinical Dentistry
https://www.readbyqxmd.com/read/29272086/acquisition-of-a-digital-intraoral-scanning-device-an-examination-of-practice-volume-changes-and-the-economic-impact-via-an-interrupted-time-series-analysis
#11
Michael M Mackay, Mohammad Fallah, Tiffany Danyal
OBJECTIVES: To evaluate the impact of digital scanning in general dental practices and orthodontic practices to determine the percentage of lift, i.e., the percent increase in gross receipts, of Invisalign® treatment starts following the introduction of an iTero® intraoral scanner. METHODS: An interrupted time series analysis was conducted on 48 months (24 pre- and 24 post-scanner introduction) of Invisalign receipt data from 1,871 general practitioner (GP) and orthodontic practices located worldwide...
November 2017: Journal of Clinical Dentistry
https://www.readbyqxmd.com/read/29211953/the-effect-of-a-toothbrush-handle-design-in-combating-microbial-contamination
#12
Sara H Rosenberg, Cliff Lee, John D Da Silva, George Chen, Shigemi Ishikawa-Nagai, Masazumi Nagai
OBJECTIVES: This study aims to assess the difference in microbial contamination of a toothbrush with a smooth handle versus a toothbrush with a grooved handle design. METHODS: Twenty-six volunteers were randomized into two groups. The first group used a smooth handle toothbrush for two months, followed by a grooved handle toothbrush for two months. The second group had the order reversed. Following the two-month use, the toothbrushes were submitted for microbial analysis...
September 2017: Journal of Clinical Dentistry
https://www.readbyqxmd.com/read/29211952/a-profilometry-based-dentifrice-abrasion-method-for-v8-brushing-machines-part-iii-multi-laboratory-validation-testing-of-rda-pe
#13
Eva Schneiderman, Ellen L Colón, Donald J White, Bruce Schemehorn, Tara Ganovsky, Amir Haider, Franklin Garcia-Godoy, Brian R Morrow, Viritpon Srimaneepong, Sujin Chumprasert
OBJECTIVES: We have previously reported on progress toward the refinement of profilometry-based abrasivity testing of dentifrices using a V8 brushing machine and tactile or optical measurement of dentin wear. The general application of this technique may be advanced by demonstration of successful inter-laboratory confirmation of the method. The objective of this study was to explore the capability of different laboratories in the assessment of dentifrice abrasivity using a profilometry-based evaluation technique developed in our Mason laboratories...
September 2017: Journal of Clinical Dentistry
https://www.readbyqxmd.com/read/29211951/a-double-blinded-randomized-study-evaluating-the-in-vivo-effects-of-a-novel-dental-gel-on-enamel-surface-microstructure-and-microhardness
#14
Afarin Golabgir Anbarani, Jessica Ho, Thinh Hung Vu, Ali Forghany, Tracie Lam, Erisa Khashai, Karan Sahni, Thair Takesh, Petra Wilder-Smith
OBJECTIVES: The objective of this study was to evaluate the in vivo effects of a 2.6% edathamil gel (Livionex® Dental Gel) on surface microhardness and microstructure in 180 pre-eroded enamel chips. METHODS: This was a double-blind, randomized study. Two enamel chips each were cut from 90 healthy sterilized extracted teeth. One chip from each pair underwent microhardness testing and scanning electron microscopy (SEM) to establish baselines. The remaining 90 samples were demineralized, and then mounted onto intra-oral retainers worn by nine subjects, with five chips mounted on each retainer for each of the two study arms...
September 2017: Journal of Clinical Dentistry
https://www.readbyqxmd.com/read/29211950/two-randomized-clinical-studies-to-confirm-differential-plaque-removal-by-sodium-bicarbonate-dentifrices-in-a-single-timed-brushing-model
#15
Stephen Mason, Ritu Karwal, Mary Lynn Bosma
OBJECTIVES: This study evaluated and compared plaque removal efficacy of commercially available dentifrices containing sodium bicarbonate (NaHCO3) to those without NaHCO3 in a single timed brushing clinical study model. METHODS: Two randomized, examiner-blind, three-period, three-treatment, crossover studies were performed in adults with a mean Turesky modification of the Quigley-Hein Plaque Index (TPI) score of = 2.00. In Study 1, 60 subjects were randomized to commercially available dentifrices containing: (i) 67% NaHCO3 plus 1425 ppm fluoride (F) as sodium fluoride (NaF); (ii) 45% NaHCO3 plus 1425 ppm F as NaF; or (iii) 0% NaHCO3 plus silica and 1450 ppm F as NaF...
September 2017: Journal of Clinical Dentistry
https://www.readbyqxmd.com/read/29211949/fluoride-uptake-profiles-of-selected-european-toothpastes-into-hard-tissues-and-plaque
#16
Joel Moore, Eva Schneiderman, Teresa Farmer, Marianne Zsiska
OBJECTIVES: To compare the fluoridating potential of selected European toothpastes using a combination of enamel, dentin, and plaque in vitromodels. METHODS: Four in vitromodels were included: 1) Enamel Fluoride (F) Uptake (EFU); 2) Dentin F Uptake (DFU); 3) Enamel Solubility Reduction (ESR); and 4) Plaque F Uptake (PFU). A core set of marketed products was included in all studies, plus a standard toothpaste (1100 ppm F as NaF/silica) and placebo control (the PFU study did not include a placebo control)...
September 2017: Journal of Clinical Dentistry
https://www.readbyqxmd.com/read/28657703/a-randomized-clinical-trial-to-measure-mouth-moisturization-and-dry-mouth-relief-in-dry-mouth-subjects-using-dry-mouth-products
#17
Anto Jose, Mounir Atassi, Lucy Shneyer, Matthew Cronin
OBJECTIVES: This study examined ratings of two subjective aspects (moisturization and dry mouth relief) that may be changed following the use of dry mouth relief products (an oral gel, an oral rinse, or a mouth spray), in comparison to water over a period of four hours following a single supervised use on two separate occasions. METHODS: This was a single-center, two site, randomized, examiner blind, four treatment arm, stratified (by dry mouth screening score at baseline), parallel group study in healthy subjects with a self-reported feeling of dry mouth...
June 2017: Journal of Clinical Dentistry
https://www.readbyqxmd.com/read/28657702/in-situ-study-to-confirm-the-anticaries-potential-of-a-sodium-monofluorophosphate-dentifrice-containing-calcium-sodium-phosphosilicate
#18
C R Parkinson, M Siddiqi, S Mason, F Lippert, A T Hara, D T Zero
OBJECTIVES: A randomized, investigator-blind, five-treatment, crossover, non-inferiority study was conducted to investigate the effect of the addition of calcium sodium phosphosilicate (CSPS), an agent known to relieve dentin hypersensitivity, to a sodium monofluorophosphate (SMFP)-containing dentifrice on the enamel remineralization potential of fluoride (F), as assessed by percentage surface microhardness recovery (%SMHR) and enamel fluoride uptake (EFU) using a standard in situ caries model...
June 2017: Journal of Clinical Dentistry
https://www.readbyqxmd.com/read/28657701/clinical-effects-of-stabilized-stannous-fluoride-dentifrice-in-reducing-plaque-microbial-virulence-i-microbiological-and-receptor-cell-findings
#19
Malgorzata Klukowska, John Christian Haught, Sancai Xie, Ben Circello, Cheryl S Tansky, Deepa Khambe, Tom Huggins, Donald J White
OBJECTIVES: Lipopolysaccharides (LPSs) and lipoteichoic acids (LTAs), or bacterial endotoxins, bind with Toll-like receptors (TLRs) that are expressed on host cells of the periodontium, thereby contributing to the periodontal pathogenicity of oral bacteria. Stannous fluoride (SnF2), an antibacterial fluoride that treats and controls gingivitis, has been shown to react with lipophilic domains/anionic charges in LPS and LTA. The effects of bacterial species and dental plaque on toll receptors can be studied using genetically engineered cell lines containing linked toll receptors on their surfaces...
June 2017: Journal of Clinical Dentistry
https://www.readbyqxmd.com/read/28657700/a-randomized-clinical-study-to-evaluate-the-efficacy-of-an-experimental-3-75-w-w-potassium-chloride-dentifrice-for-the-relief-of-dentin-hypersensitivity
#20
Sarah Young, Nan Wang, Stephen Mason, Farzana Sufi
OBJECTIVES: To evaluate the clinical efficacy of an experimental "Test" dentifrice containing 3.75% (w/w) potassium chloride (KCl) in reducing dentin hypersensitivity (DH) compared with that of a standard fluoride "Reference" dentifrice after eight weeks' twice-daily brushing. METHODS: This was a randomized, controlled, examiner-blind, stratified, parallel-group, single-center study in healthy subjects with selfreported and clinically diagnosed DH. After an initial lead-in period, subjects were randomized to either the Test (n = 67) or the Reference dentifrice (n = 66) and instructed to brush twice daily for the next eight weeks...
June 2017: Journal of Clinical Dentistry
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