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Stereotactic and Functional Neurosurgery

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https://www.readbyqxmd.com/read/29444523/a-novel-animal-model-of-parkinson-s-disease-using-optogenetics-representation-of-various-disease-stages-by-modulating-the-illumination-parameter
#1
Eun Jung Lee, Hyung Ho Yoon, Eun Suk Park, Joongkee Min, Sang Ryong Jeon
BACKGROUND: The classic animal model of Parkinson's disease (PD) using neurotoxin can only simulate fixed stages of the disease by causing irreversible damage to the nigrostriatal system. OBJECTIVES: To develop an optogenetic PD model that can modulate the severity of disease by optical stimulation by introducing the halorhodopsin (NpHR) gene into the substantia nigra compacta. METHODS: Fifteen rats received injections of engineered AAV with NpHR-YFP gene into the substantia nigra...
February 14, 2018: Stereotactic and Functional Neurosurgery
https://www.readbyqxmd.com/read/29433124/thalamic-deep-brain-stimulation-salvages-failed-focused-ultrasound-thalamotomy-for-essential-tremor-a-case-report
#2
Tony R Wang, Robert F Dallapiazza, Shayan Moosa, Diane Huss, Binit B Shah, W Jeffrey Elias
BACKGROUND: A recent randomized controlled trial investigating unilateral MRI-guided focused ultrasound (FUS) for essential tremor demonstrated efficacy. The long-term durability of this thalamotomy, however, is unknown. Furthermore, the feasibility of stimulating a previously lesioned target such as the thalamic nucleus ventralis intermedius (Vim) is poorly understood. We report a case of tremor recurrence, following an initially successful FUS thalamotomy, in which Vim-DBS was subsequently utilized to regain tremor control...
February 12, 2018: Stereotactic and Functional Neurosurgery
https://www.readbyqxmd.com/read/29414819/dbstar-an-open-source-tool-kit-for-imaging-analysis-with-patient-customized-deep-brain-stimulation-platforms
#3
Peter M Lauro, Shane Lee, Minkyu Ahn, Andrei Barborica, Wael F Asaad
BACKGROUND/OBJECTIVES: To create an open-source method for reconstructing microelectrode recording (MER) and deep brain stimulation (DBS) electrode coordinates along multiple parallel trajectories with patient-specific DBS implantation platforms to facilitate DBS research. METHODS: We combined the surgical geometry (extracted from WayPoint Planner), pre-/intra-/postoperative computed tomography (CT) and/or magnetic resonance (MR) images, and integrated them into the Analysis of Functional NeuroImages (AFNI) neuroimaging analysis environment using functions written in Python...
February 7, 2018: Stereotactic and Functional Neurosurgery
https://www.readbyqxmd.com/read/29414816/battery-life-matters-in-deep-brain-stimulation
#4
Kawngwoo Park, Yong Hoon Lim, Mihee Jang, Aryun Kim, Han-Joon Kim, Sun Ha Paek, Beomseok Jeon
No abstract text is available yet for this article.
February 7, 2018: Stereotactic and Functional Neurosurgery
https://www.readbyqxmd.com/read/29408817/prelemniscal-lesion-for-selective-improvement-of-parkinson-disease-tremor
#5
Francisco Velasco, Mauricio Esqueda-Liquidano, Ana Luisa Velasco, Maria Guadalupe García-Gomar
BACKGROUND: Selective improvement of symptoms may be required when treating Parkinson disease (PD) patients with a predominantly monosymptomatic clinical picture. OBJECTIVE: To define a target in prelemniscal radiation fibers (Raprl) related to the physiopathology of tremor evidenced by tractography. CASE REPORT: We report a patient with predominant unilateral rest and postural tremor, diagnosed as PD based on 80% improvement induced by the administration of L-DOPA/carbidopa, subsequently complicated by motor fluctuations, L-DOPA dyskinesia, and a reduced ON period...
February 6, 2018: Stereotactic and Functional Neurosurgery
https://www.readbyqxmd.com/read/29393267/theoretical-effect-of-dbs-on-axonal-fibers-of-passage-firing-rates-entropy-and-information-content
#6
Jeffrey E Arle, Longzhi Z Mei, Kristen W Carlson, Jay L Shils
BACKGROUND: Deep brain stimulation (DBS) has effects on axons that originate and terminate outside the DBS target area. OBJECTIVE: We hypothesized that DBS generates action potentials (APs) in both directions in "axons of passage," altering their information content and that of all downstream cells and circuits, and sought to quantify the change in fiber information content. METHODS: We incorporated DBS parameters (fiber firing frequency and refractory time, and AP initiation location along the fiber and propagation velocity) in a filtering function determining the AP frequency reaching the postsynaptic cell...
January 27, 2018: Stereotactic and Functional Neurosurgery
https://www.readbyqxmd.com/read/29339639/mri-guided-interstitial-laser-ablation-for-intracranial-lesions-a-large-single-institution-experience-of-133-cases
#7
Ashwin A Kamath, Daniel D Friedman, Carl D Hacker, Matthew D Smyth, David D Limbrick, Albert H Kim, Ammar H Hawasli, Eric C Leuthardt
BACKGROUND: Managing difficult-to-access lesions or surgically accessible lesions in fragile patients is a central problem in neurosurgery. MRI-guided interstitial laser ablation (ILA) is a minimally invasive option that may provide a safe means of treating these challenging patients. OBJECTIVE: We aim to (1) evaluate safety, efficacy, and preliminary outcomes within a diverse and large series of ILA treatments; and (2) report technical details and operative trends that proved useful over time in the authors' experience and that may be of use to neurosurgeons who perform ILA...
January 17, 2018: Stereotactic and Functional Neurosurgery
https://www.readbyqxmd.com/read/29316566/double-anterior-stereotactic-cingulotomy-for-intractable-oncological-pain
#8
Ido Strauss, Assaf Berger, Shlomit Ben Moshe, Michal Arad, Uri Hochberg, Tal Gonen, Rotem Tellem
BACKGROUND: Stereotactic anterior cingulotomy has been used in the treatment of patients suffering from refractory oncological pain due to its effects on pain perception. However, the optimal targets as well as suitable candidates and outcome measures have not been well defined. We report our initial experience in the ablation of 2 cingulotomy targets on each side and the use of the Brief Pain Inventory (BPI) as a perioperative assessment tool. METHODS: A retrospective review of all patients who underwent stereotactic anterior cingulotomy in our Department between November 2015 and February 2017 was performed...
January 10, 2018: Stereotactic and Functional Neurosurgery
https://www.readbyqxmd.com/read/29316547/o-arm-guided-percutaneous-radiofrequency-cordotomy
#9
Ido Strauss, Assaf Berger, Michal Arad, Uri Hochberg, Rotem Tellem
BACKGROUND: Pain is often one of the most debilitating symptoms in patients with advanced oncological disease. Patients with localized pain due to malignancy refractory to medical treatment can benefit from selective percutaneous cordotomy that disconnects the ascending pain fibers in the spinothalamic tract. OBJECTIVES: Over the past year, we have been performing percutaneous radiofrequency cordotomy with the use of the O-Arm intraoperative imaging system that allows both 2D fluoroscopy and 3D reconstructed computerized tomography imaging...
January 10, 2018: Stereotactic and Functional Neurosurgery
https://www.readbyqxmd.com/read/29301132/optical-measurements-during-deep-brain-stimulation-lead-implantation-safety-aspects
#10
Peter Zsigmond, Simone Hemm-Ode, Karin Wårdell
BACKGROUND: Intracerebral hemorrhage (ICH) is the most feared complication in deep brain stimulation (DBS) surgery. The aim of the study was to evaluate patient safety and outcome using laser Doppler flowmetry (LDF) as guidance tool during DBS implantations. METHODS: An LDF probe adapted for the stereotactic system was used as guide for creation of the trajectory. The microcirculation along 83 preplanned trajectories was measured with the guide during DBS surgery for movement disorders...
January 5, 2018: Stereotactic and Functional Neurosurgery
https://www.readbyqxmd.com/read/29232685/surgical-management-of-deep-brain-stimulator-scalp-erosion-without-hardware-removal
#11
Michael D Staudt, Navid Pourtaheri, Gregory E Lakin, Hooman T Soltanian, Jonathan P Miller
BACKGROUND: Scalp erosion in patients with deep brain stimulation (DBS) hardware is an uncommon complication that lacks a clearly defined management strategy. Previous studies have described various therapies including conservative treatment with antibiotics and surgical debridement with or without hardware removal. OBJECTIVES: The aim of this study was to review the efficacy of a hardware-sparing management strategy for the treatment of scalp erosion. METHODS: Five patients with previous DBS implantation presented with scalp erosion and visible hardware exposure at the calvarial burr hole site, and underwent tension-free, vascularized, rotational scalp flap, with preservation of the leads under the pericranium...
December 13, 2017: Stereotactic and Functional Neurosurgery
https://www.readbyqxmd.com/read/29190619/ruptured-de-novo-aneurysm-following-gamma-knife-surgery-for-arteriovenous-malformation-case-report
#12
Yun-Sik Dho, Dong Gyu Kim, Hyun-Tai Chung
Stereotactic radiosurgery is a well-known treatment tool for arteriovenous malformations (AVMs). The method has high validity and minimal invasiveness, but late-onset problems involving tumor formation and vasculopathy induced by radiation have been reported. We present a rare case of a radiation-induced ruptured de novo aneurysm following Gamma Knife surgery (GKS) for an AVM. A 17-year-old, right-handed male underwent GKS for AVM at the left parietal lobe. After 3 years, a follow-up angiogram showed a residual AVM at the angular gyrus...
December 1, 2017: Stereotactic and Functional Neurosurgery
https://www.readbyqxmd.com/read/29131131/gamma-knife-stereotactic-radiosurgery-for-the-treatment-of-primary-and-metastatic-ocular-malignancies
#13
Andrea L H Arnett, Margaret M Reynolds, Jose S Pulido, Ian F Parney, Nadia N Laack
BACKGROUND: Gamma knife radiosurgery (GKR) can be used for precise targeting of malignant lesions of the CNS when brachytherapy is not an appropriate option. OBJECTIVES: This study reports treatment technique, efficacy, and radiation-induced adverse effects in patients with primary and metastatic ocular lesions treated with Leksell GKR. METHODS: A retrospective, single-institution review was conducted of 28 patients with primary or metastatic ocular disease, treated from 2000 to 2014...
November 4, 2017: Stereotactic and Functional Neurosurgery
https://www.readbyqxmd.com/read/29131117/significant-hemorrhage-rate-reduction-after-gamma-knife-radiosurgery-in-symptomatic-cavernous-malformations-long-term-outcome-in-95-case-series-and-literature-review
#14
Remedios López-Serrano, Nuria E Martínez, M Elena Kusak, Alicia Quirós, Roberto Martínez
BACKGROUND: The natural history of cavernous malformations (CMs) has remained unclear. This lack of knowledge has made treatment decisions difficult. Indeed, the use of stereotactic radiosurgery is nowadays controversial. The purpose of this paper is to throw light on the effectiveness of Gamma Knife radiosurgery (GKRS) therapy. METHODS: The authors reviewed data collected from a prospectively maintained database. A total of 95 patients (57 female and 38 male) underwent GKRS for high-surgical-risk CMs...
November 4, 2017: Stereotactic and Functional Neurosurgery
https://www.readbyqxmd.com/read/29017157/impact-of-the-number-of-metastatic-tumors-treated-by-stereotactic-radiosurgery-on-the-dose-to-normal-brain-implications-for-brain-protection
#15
Charlotte Rivers, Marissa Tranquilli, Shefalika Prasad, Evan Winograd, Robert J Plunkett, Robert A Fenstermaker, Andrew J Fabiano, Matthew B Podgorsak, Dheerendra Prasad
PURPOSE/OBJECTIVES: The purpose of this study was to evaluate the effect of the number of brain lesions for which stereotactic radiosurgery (SRS) was performed on the dose volume relationships in normal brain. MATERIALS AND METHODS: Brain tissue was segmented using the patient's pre-SRS MRI. For each plan, the following data points were recorded: total brain volume, number of lesions treated, volume of brain receiving 8 Gy (V8), V10, V12, and V15. RESULTS: A total of 225 Gamma Knife® treatments were included in this retrospective analysis...
October 11, 2017: Stereotactic and Functional Neurosurgery
https://www.readbyqxmd.com/read/28910805/infection-and-erosion-rates-in-trials-of-a-cranially-implanted-neurostimulator-do-not-increase-with-subsequent-neurostimulator-placements
#16
Peter B Weber, Ritu Kapur, Ryder P Gwinn, Richard S Zimmerman, Tracy A Courtney, Martha J Morrell
BACKGROUND/AIMS: The RNS® System utilizes a cranially implanted neurostimulator attached to leads placed at the seizure focus to provide brain responsive stimulation for the treatment of medically intractable partial onset epilepsy. Infection and erosion rates related to the cranial implant site were assessed overall and by neurostimulator procedure to determine whether rates increased with additional procedures. METHODS: Infection and erosion rates were calculated as (1) chance per neurostimulator procedure, (2) incidence per patient implant year, and (3) rates for initial and each subsequent neurostimulator implant (generalized estimating equation)...
September 15, 2017: Stereotactic and Functional Neurosurgery
https://www.readbyqxmd.com/read/28869946/stereotactic-radiosurgery-for-intractable-tremor-dominant-parkinson-disease-a-retrospective-analysis
#17
Sudesh S Raju, Ajay Niranjan, Edward A Monaco Iii, John C Flickinger, L Dade Lunsford
OBJECTIVE: The purpose of this study was to retrospectively analyze the outcomes of stereotactic radiosurgery for patients suffering from medically refractory Parkinson disease (PD) tremor. METHODS: We retrospectively studied the outcomes of 33 patients who were treated with gamma knife thalamotomy (GKT) over a 19-year period. Twelve patients were ≥80 years. A median dose of 140 Gy (range, 130-150 Gy) was delivered to the nucleus ventralis intermedius through a single 4-mm isocenter...
September 2, 2017: Stereotactic and Functional Neurosurgery
https://www.readbyqxmd.com/read/28848107/deep-brain-stimulation-for-the-treatment-of-dejerine-roussy-syndrome
#18
Max Ward, Antonios Mammis
BACKGROUND/AIMS: Patients who suffer from Dejerine-Roussy syndrome commonly experience severe poststroke hemibody pain which has historically been attributed to thalamic lesions. Despite pharmacological treatment, a significant proportion of the population is resistant to traditional therapy. Deep brain stimulation is often appropriate for the treatment of resistant populations. In this review we aim to summarize the targets that are used to treat Dejerine-Roussy syndrome and provide insight into their clinical efficacy...
August 25, 2017: Stereotactic and Functional Neurosurgery
https://www.readbyqxmd.com/read/28641280/17th-quadrennial-meeting-of-the-world-society-for-stereotactic-and-functional-neurosurgery-berlin-germany-june-26-29-2017-abstracts
#19
(no author information available yet)
No abstract text is available yet for this article.
June 22, 2017: Stereotactic and Functional Neurosurgery
https://www.readbyqxmd.com/read/29017175/body-weight-changes-after-deep-brain-stimulation-for-obsessive-compulsive-disorder-or-depression
#20
Rosalie S N Linssen, Marloes S Oudijn, Mariska Mantione, Pepijn van den Munckhof, Damiaan Denys, P Richard Schuurman
BACKGROUND: In 2010, we published an often-cited case report describing smoking cessation and substantial weight loss after deep brain stimulation (DBS) for obsessive-compulsive disorder (OCD) in an obese patient. To test whether this single observation was also observed in the treated population at large, the weight changes of a larger cohort of patients who underwent DBS for OCD or major depressive disorder (MDD) were studied. RESULTS: Data were available for 46 patients (30 OCD and 16 MDD patients; mean age 46...
2017: Stereotactic and Functional Neurosurgery
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