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Stereotactic and Functional Neurosurgery

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https://www.readbyqxmd.com/read/30021213/large-volume-infusions-into-the-brain-a-comparative-study-of-catheter-designs
#1
Martin L Brady, Raghu Raghavan, Jaime Mata, Mike Wilson, Scott Wilson, Rick M Odland, William C Broaddus
BACKGROUND/AIMS: "Whole-brain" infusions have emerged as a potential need with the promise of disease-modifying therapies for neurodegenerative diseases. In addition, several current clinical trials in brain cancer utilize direct delivery of drugs that are required to fill large volumes. Such requirements may not be well served by conventional single port catheters with their "point source" of delivery. Our aim is to examine infusions into large volumes of heterogeneous tissue, aiming for uniformity of distribution...
July 18, 2018: Stereotactic and Functional Neurosurgery
https://www.readbyqxmd.com/read/29975951/unilateral-left-deep-brain-stimulation-of-the-caudal-zona-incerta-is-equally-effective-on-voice-tremor-as-bilateral-stimulation-evidence-from-7-patients-with-essential-tremor
#2
Linda Sandström, Fredrik Karlsson, Patric Blomstedt
BACKGROUND/AIMS: Deep brain stimulation (DBS) is less effective on voice tremor than arm tremor, and it is generally assumed that successful voice tremor treatment requires bilateral DBS and possibly more precise thalamic stimulation. However, recent findings suggest that these assumptions should be reconsidered. OBJECTIVES: To evaluate whether unilateral DBS targeting the caudal zona incerta (cZi) may be sufficient to alleviate voice tremor in patients with essential tremor, or whether bilateral stimulation is needed...
July 4, 2018: Stereotactic and Functional Neurosurgery
https://www.readbyqxmd.com/read/29969770/gamma-knife-radiosurgery-for-metastatic-brain-tumors-from-malignant-melanomas-a-japanese-multi-institutional-cooperative-and-retrospective-cohort-study-jlgk1501
#3
Shigeo Matsunaga, Takashi Shuto, Masaaki Yamamoto, Shoji Yomo, Takeshi Kondoh, Tatsuya Kobayashi, Manabu Sato, Hisayo Okamoto, Toru Serizawa, Osamu Nagano, Hiroyuki Kenai, Takuma Obara, Yoshiyasu Iwai, Soichiro Yasuda, Toshinori Hasegawa, Kenji Kubo, Satoka Shidoh, Katsuharu Mori, Motohiro Hayashi, Akira Inoue, Shinji Onoue, Masazumi Gondo
BACKGROUND: The incidences of metastatic brain tumors from malignant melanomas have increased and survival has been prolonged by novel molecular targeted agents and immunotherapy. However, malignant melanomas are uncommon in Asian populations. OBJECTIVES: We retrospectively analyzed treatment efficacy and identified prognostic factors impacting tumor control and survival in Japanese melanoma patients with brain metastases treated with gamma knife radiosurgery (GKRS)...
July 3, 2018: Stereotactic and Functional Neurosurgery
https://www.readbyqxmd.com/read/29920479/battery-longevity-comparison-of-two-commonly-available-dual-channel-implantable-pulse-generators-used-for-subthalamic-nucleus-stimulation-in-parkinson-s-disease
#4
Benjamin Fisher, Jamilla Kausar, Hayley Garratt, James Hodson, Anwen White, Ismail Ughratdar, Rosalind Mitchell
OBJECTIVES: Deep brain stimulation for Parkinson's disease (PD) utilises an implantable pulse generator (IPG) whose finite lifespan in non-rechargeable systems necessitates their periodic replacement. We wish to determine if there is any significant difference in longevity of 2 commonly used IPG systems; the Medtronic Kinetra, and the Medtronic Activa Primary Cell (PC), which has come to replace it. METHODS: All patients with bilateral Subthalamic Nucleus stimulators for PD performed in our centre were included...
June 19, 2018: Stereotactic and Functional Neurosurgery
https://www.readbyqxmd.com/read/29898460/development-of-a-standardized-cranial-phantom-for-training-and-optimization-of-functional-stereotactic-operations
#5
Marie T Krüger, Volker A Coenen, Karl Egger, Mukesch Shah, Peter C Reinacher
BACKGROUND: In recent years, simulations based on phantom models have become increasingly popular in the medical field. In the field of functional and stereotactic neurosurgery, a cranial phantom would be useful to train operative techniques, such as stereo-electroencephalography (SEEG), to establish new methods as well as to develop and modify radiological techniques. In this study, we describe the construction of a cranial phantom and show examples for it in stereotactic and functional neurosurgery and its applicability with different radiological modalities...
June 13, 2018: Stereotactic and Functional Neurosurgery
https://www.readbyqxmd.com/read/29698968/gamma-knife-stereotactic-radiosurgery-for-the-treatment-of-brain-metastases-from-primary-tumors-of-the-urinary-bladder
#6
James M Taylor, Emory R McTyre, Stephen B Tatter, Adrian W Laxton, Michael T Munley, Michael D Chan, Christina K Cramer
BACKGROUND/AIMS: Brain metastases from bladder cancer are rare and published outcomes data are sparse. To date, no institutions have reported a series of patients with brain metastases from bladder cancer treated with stereotactic radiosurgery (SRS). Our aim was to identify patients with brain metastases from bladder primaries treated with SRS with or without surgical resection and report the clinical outcomes. METHODS: Patients meeting eligibility criteria at our institution between 2000 and 2017 were included...
April 26, 2018: Stereotactic and Functional Neurosurgery
https://www.readbyqxmd.com/read/29614489/hyperbaric-oxygen-therapy-as-adjuvant-treatment-for-hardware-related-infections-in-neuromodulation
#7
Jiri Bartek, Simon Skyrman, Michael Nekludov, Tiit Mathiesen, Folke Lind, Gaston Schechtmann
BACKGROUND: In neuromodulation therapies, hardware-related infections are a major challenge often leading to hardware removal. OBJECTIVE: To investigate the role of adjuvant hyperbaric oxygen therapy (HBOT) in hardware-related infections. METHODS: Fourteen hardware-related infection events in 12 consecutive patients between 2002 and 2015 were treated with antibiotics and adjuvant HBOT at the Karolinska University Hospital (Stockholm, Sweden)...
April 3, 2018: Stereotactic and Functional Neurosurgery
https://www.readbyqxmd.com/read/29886479/intrathecal-baclofen-therapy-for-painful-muscle-spasms-in-a-patient-with-friedreich-s-ataxia
#8
Aristotelis V Kalyvas, Evangelos Drosos, Stefanos Korfias, Stylianos Gatzonis, Marios Themistocleous, Damianos E Sakas
Friedreich's ataxia (FA) is the most frequent hereditary ataxia syndrome, while painful muscle spasms and spasticity have been reported in 11-15% of FA patients. This report describes the successful management of painful spasms in a 65-year-old woman with FA via intrathecal baclofen (ITB) therapy following unsuccessful medical treatments. To our knowledge, this is the third reported case in the literature. Unfortunately, the pathophysiological characteristics of muscle spasms in FA are not well explored and understood while the therapeutic mechanisms of the different treatments are rather vague...
2018: Stereotactic and Functional Neurosurgery
https://www.readbyqxmd.com/read/29860250/estimating-accurate-target-coordinates-with-magnetic-resonance-images-by-using-multiple-phase-encoding-directions-during-acquisition
#9
Minsoo Kim, Na Young Jung, Chang Kyu Park, Won Seok Chang, Hyun Ho Jung, Jin Woo Chang
BACKGROUND: Stereotactic procedures are image guided, often using magnetic resonance (MR) images limited by image distortion, which may influence targets for stereotactic procedures. OBJECTIVES: The aim of this work was to assess methods of identifying target coordinates for stereotactic procedures with MR in multiple phase-encoding directions. METHODS: In 30 patients undergoing deep brain stimulation, we acquired 5 image sets: stereotactic brain computed tomography (CT), T2-weighted images (T2WI), and T1WI in both right-to-left (RL) and anterior-to-posterior (AP) phase-encoding directions...
2018: Stereotactic and Functional Neurosurgery
https://www.readbyqxmd.com/read/29847829/asleep-deep-brain-stimulation-reduces-incidence-of-intracranial-air-during-electrode-implantation
#10
Andrew L Ko, Philippe Magown, Alp Ozpinar, Vural Hamzaoglu, Kim J Burchiel
BACKGROUND: Asleep deep brain stimulation (aDBS) implantation replaces microelectrode recording for image-guided implantation, shortening the operative time and reducing cerebrospinal fluid egress. This may decrease pneumocephalus, thus decreasing brain shift during implantation. OBJECTIVE: To compare the incidence and volume of pneumocephalus during awake (wkDBS) and aDBS procedures. METHODS: A retrospective review of bilateral DBS cases performed at Oregon Health & Science University from 2009 to 2017 was undertaken...
2018: Stereotactic and Functional Neurosurgery
https://www.readbyqxmd.com/read/29847826/subthalamic-nucleus-visualization-on-routine-clinical-preoperative-mri-scans-a-retrospective-study-of-clinical-and-image-characteristics-predicting-its-visualization
#11
Manish Ranjan, Alexandre Boutet, David S Xu, Christopher S Lozano, Rajeev Kumar, Alfonso Fasano, Walter Kucharczyk, Andres M Lozano
BACKGROUND: The visualization of the subthalamic nucleus (STN) on magnetic resonance imaging (MRI) is variable. Studies of the contribution of patient-related factors and intrinsic brain volumetrics to STN visualization have not been reported previously. OBJECTIVE: To assess the visualization of the STN during deep brain stimulation (DBS) surgery in a clinical setting. METHODS: Eighty-two patients undergoing pre-operative MRI to plan for STN DBS for Parkinson disease were retrospectively studied...
2018: Stereotactic and Functional Neurosurgery
https://www.readbyqxmd.com/read/29791914/atlas-independent-electrophysiological-mapping-of-the-optimal-locus-of-subthalamic-deep-brain-stimulation-for-the-motor-symptoms-of-parkinson-disease
#12
Erin C Conrad, James M Mossner, Kelvin L Chou, Parag G Patil
BACKGROUND/AIMS: Deep brain stimulation (DBS) of the subthalamic nucleus (STN) improves motor symptoms of Parkinson disease (PD). However, motor outcomes can be variable, perhaps due to inconsistent positioning of the active contact relative to an unknown optimal locus of stimulation. Here, we determine the optimal locus of STN stimulation in a geometrically unconstrained, mathematically precise, and atlas-independent manner, using Unified Parkinson Disease Rating Scale (UPDRS) motor outcomes and an electrophysiological neuronal stimulation model...
2018: Stereotactic and Functional Neurosurgery
https://www.readbyqxmd.com/read/29768273/subcaudate-tractotomy-white-matter-anatomy-and-variability-a-diffusion-tensor-imaging-study
#13
Kartik D Bhatia, Luke A Henderson, Eugene Hsu, Mark Yim
BACKGROUND: Subcaudate tractotomy is a functional ablative procedure performed for treatment-resistant psychiatric disease, targeting the white matter tracts ventral to the head of the caudate nucleus. The white matter anatomy of this region has extensive interindividual variability, and this is thought to impact upon the treatment response to ablative and deep brain stimulation procedures. OBJECTIVE: We aim to assess in detail the white matter tract anatomy and topographic variability underlying subcaudate tractotomy...
2018: Stereotactic and Functional Neurosurgery
https://www.readbyqxmd.com/read/29539606/a-retrospective-analysis-of-the-outcomes-of-dural-arteriovenous-fistulas-treated-with-gamma-knife-radiosurgery-a-single-institution-experience
#14
Youngbeom Seo, Dong Gyu Kim, Yun-Sik Dho, Jin Wook Kim, Yong Hwy Kim, Chul-Kee Park, Hyun-Tai Chung, Sun-Ha Paek
BACKGROUND: Gamma knife radiosurgery (GKRS) has recently been used as a treatment modality for dural arteriovenous fistula (DAVF). OBJECTIVE: To retrospectively analyze the outcomes of GKRS for DAVF at a single institute. METHODS: Between 1998 and 2016, a total of 20 patients underwent GKRS for DAVF. After excluding 4 patients with > 12 months of follow-up, 16 patients were enrolled in this study. Twelve patients had undergone embolization prior to GKRS...
2018: Stereotactic and Functional Neurosurgery
https://www.readbyqxmd.com/read/29533964/prelimbic-cortex-deep-brain-stimulation-reduces-binge-size-in-a-chronic-binge-eating-rat-model
#15
Can Sarica, Mazhar Ozkan, Husniye Hacioglu Bay, Umit Sehirli, Filiz Onat, M Ibrahim Ziyal
BACKGROUND: Binge eating (BE) involves the consumption of a large amount of food in a short period of time and a loss of control during the binge episode. It is a key feature of the major subtypes of eating disorders like bulimia nervosa, BE disorder, anorexia nervosa binge/purge type. Alterations in the mesocorticolimbic pathway play a crucial role in its pathophysiology. OBJECTIVES: We hypothesized that BE rats receiving deep brain stimulation (DBS) in the prelimbic cortex, a functional analog of the dorsolateral prefrontal cortex in humans, would have a reduced binge size compared with those receiving sham stimulation...
2018: Stereotactic and Functional Neurosurgery
https://www.readbyqxmd.com/read/29495014/venous-thromboembolism-during-interventional-mri-guided-stereotactic-surgery
#16
Adam J Kundishora, Dario J Englot, Philip A Starr, Alastair J Martin, Paul S Larson
BACKGROUND/AIMS: Interventional MRI (iMRI) allows real-time confirmation of electrode and microcatheter location in anesthetized patients; however, MRI-compatible pneumatic compression devices (PCD) to reduce the periprocedural venous thromboembolism (VTE) risk are not commercially available. Given the paucity of literature on VTE following iMRI surgery, better characterizing patients suffering this complication and the incidence of this event following iMRI procedures is pivotal for defining best surgical practices...
2018: Stereotactic and Functional Neurosurgery
https://www.readbyqxmd.com/read/29444523/a-novel-animal-model-of-parkinson-s-disease-using-optogenetics-representation-of-various-disease-stages-by-modulating-the-illumination-parameter
#17
Eun Jung Lee, Hyung Ho Yoon, Eun Suk Park, Joongkee Min, Sang Ryong Jeon
BACKGROUND: The classic animal model of Parkinson's disease (PD) using neurotoxin can only simulate fixed stages of the disease by causing irreversible damage to the nigrostriatal system. OBJECTIVES: To develop an optogenetic PD model that can modulate the severity of disease by optical stimulation by introducing the halorhodopsin (NpHR) gene into the substantia nigra compacta. METHODS: Fifteen rats received injections of engineered AAV with NpHR-YFP gene into the substantia nigra...
2018: Stereotactic and Functional Neurosurgery
https://www.readbyqxmd.com/read/29433124/thalamic-deep-brain-stimulation-salvages-failed-focused-ultrasound-thalamotomy-for-essential-tremor-a-case-report
#18
Tony R Wang, Robert F Dallapiazza, Shayan Moosa, Diane Huss, Binit B Shah, W Jeffrey Elias
BACKGROUND: A recent randomized controlled trial investigating unilateral MRI-guided focused ultrasound (FUS) for essential tremor demonstrated efficacy. The long-term durability of this thalamotomy, however, is unknown. Furthermore, the feasibility of stimulating a previously lesioned target such as the thalamic nucleus ventralis intermedius (Vim) is poorly understood. We report a case of tremor recurrence, following an initially successful FUS thalamotomy, in which Vim-DBS was subsequently utilized to regain tremor control...
2018: Stereotactic and Functional Neurosurgery
https://www.readbyqxmd.com/read/29414819/dbstar-an-open-source-tool-kit-for-imaging-analysis-with-patient-customized-deep-brain-stimulation-platforms
#19
Peter M Lauro, Shane Lee, Minkyu Ahn, Andrei Barborica, Wael F Asaad
BACKGROUND/OBJECTIVES: To create an open-source method for reconstructing microelectrode recording (MER) and deep brain stimulation (DBS) electrode coordinates along multiple parallel trajectories with patient-specific DBS implantation platforms to facilitate DBS research. METHODS: We combined the surgical geometry (extracted from WayPoint Planner), pre-/intra-/postoperative computed tomography (CT) and/or magnetic resonance (MR) images, and integrated them into the Analysis of Functional NeuroImages (AFNI) neuroimaging analysis environment using functions written in Python...
2018: Stereotactic and Functional Neurosurgery
https://www.readbyqxmd.com/read/29414816/battery-life-matters-in-deep-brain-stimulation
#20
Kawngwoo Park, Yong Hoon Lim, Mihee Jang, Aryun Kim, Han-Joon Kim, Sun Ha Paek, Beomseok Jeon
No abstract text is available yet for this article.
2018: Stereotactic and Functional Neurosurgery
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