journal
MENU ▼
Read by QxMD icon Read
search

Journal of Chemical Neuroanatomy

journal
https://www.readbyqxmd.com/read/27914953/both-secreted-and-the-cellular-levels-of-bdnf-attenuated-due-to-tau-hyperphosphorylation-in-primary-cultures-of-cortical-neurons
#1
İrem Lütfiye Atasoy, Erdinç Dursun, Duygu Gezen Ak, Derya Metin Armağan, Melek Öztürk, Selma Yılmazer
Intracellular aggregation of hyperphosphorylated tau in neurofibrillary tangles (NFTs) is a major neuropathological hallmark of taupathies such as Alzheimer's disease. Okadaic acid (OKA) is a potent inhibitor of PP2A, leading to abnormal tau phosphorylation. Brain-derived neurotrophic factor (BDNF) is a neurotrophin that is selectively downregulated in AD. In this study, we investigated the effects of OKA induced tau hyperphosphorylation on secreted and cellular levels of BDNF in primary cortical neurons that were treated with 25nM OKA...
November 30, 2016: Journal of Chemical Neuroanatomy
https://www.readbyqxmd.com/read/27913184/tolerance-of-hyperammonemia-in-brain-of-heteropneustes-fossilis-is-supported-by-glutamate-glutamine-cycle
#2
Suman Mishra, Rajnikant Mishra
This report presents analysis of molecular switches associated with tolerance to hyperammonemia in Heteropneustes fossilis because it tolerates about 100-fold more ammonia than mammals. Brains of Heteropneustes fossilis exposed to 100mM ammonium chloride were dissected after Zero hour as control, 16hrs and 20hrs exposure. The status of neuron and glia were analysed by Golgi staining, Luxol Fast Blue, and Nissl's staining. The expression patterns of genes associated to homeostasis of neuron and glia, management of oxidative stress and inflammation, ammonia metabolism and brain derived neurotrophic factor were analysed through reverse-transcriptase-polymerase chain reaction...
November 29, 2016: Journal of Chemical Neuroanatomy
https://www.readbyqxmd.com/read/27908658/cocaine-and-amphetamine-regulated-transcript-peptide-and-calcium-binding-proteins-immunoreactivity-in-the-superficial-layers-of-the-superior-colliculus-in-the-guinea-pig-implications-for-visual-sensory-processing
#3
Janusz Najdzion
The purpose of this study was to investigate the distribution and colocalization of cocaine- and amphetamine-regulated transcript peptide (CART) and three calcium-binding proteins (calbindin, calretinin and parvalbumin) in the superficial layers of the superior colliculus (SCs) in the guinea pig. The CART immunoreactivity was observed exclusively in the solitary fibers and neuropil, which formed various CART-ir tiers, that corresponded partially or entirely to anatomically defined layers of the SCs. The CART-ir structures exhibited a characteristic morphology with bundles of densely intermingled neuronal fibers and terminals...
November 28, 2016: Journal of Chemical Neuroanatomy
https://www.readbyqxmd.com/read/27871948/vestibular-cerebellum-of-thick-toed-geckos-chondrodactylus-turnery-gray-1864-and-c57-bl6n-mice-after-the-long-term-space-flight-on-the-biosatellite-bion-m1
#4
Proshchina Alexandra, Kharlamova Anastasia, Barabanov Valeriy, Gulimova Victoria, Saveliev Sergey
The aim of this study was to estimate the effects of long-term space flights on neuronal and glial cells of the vestibular cerebellum of C57/BL6N mice and thick-toed geckos (Chondrodactylus turnery GRAY, 1864). The cerebella from 26 mice and 13 geckos were used in this study. Ten mice and five geckos were flown aboard the BION-M1 biosatellite. The other animals were used as controls. We used immunohistochemical techniques and classical histological method to reveal cell types in the vestibular cerebellum. Nonspecific pathomorphological changes in the Purkinje cells (such as chromatolysis, vacuolization and hyperchromatosis) were observed in the flight groups...
November 18, 2016: Journal of Chemical Neuroanatomy
https://www.readbyqxmd.com/read/27865908/oleic-acid-promotes-the-expression-of-neural-markers-in-differentiated-human-endometrial-stem-cells
#5
Maryam Ali Mohammadie Kojour, Somayeh Ebrahimi-Barough, Homa Mohseni Kouchesfehani, Hanieh Jalali, Mohammah Hosein Karbalaie Ebrahim
Variety of neurodegenerative diseases in humans are caused by loss of cells along with loss of function and disability. Cell replacement therapy is a potential strategy to cure neurodegenerative diseases. Mesenchymal stem cells are pluripotent non-hematopoietic cells that can be isolated from numerous tissues. Human endometrial-derived stem cell (hEnSC) are the abundant and easy available source with no immunological response, for cell replacement therapy. In the nervous system, where fatty acids are found in huge amounts, they participate in its development and maintenance throughout life...
November 16, 2016: Journal of Chemical Neuroanatomy
https://www.readbyqxmd.com/read/27865907/differential-regulation-of-glial-reactions-in-the-central-facial-tract-and-the-facial-nucleus-after-facial-neurorrhaphy
#6
Tzu-Yin Yeh, Shang-Ming Wang, Guo-Fang Tseng, Pei-Hsin Liu
We previously reported that perineuronal astrocytic and microglial reactions are drastically upregulated in the facial nucleus after facial axotomy at the brain stem surface or the stylomastoid foramen. Furthermore, periaxonal astrocytic and microglial reactions develop retrogradely in the central facial tract which contains proximal facial axons in the brain stem. Because reconnection of interrupted peripheral nerve by microsurgical suture is a common clinical practice, the aim of this study was to investigate the spatiotemporal patterns of glial reactions in the central facial tract and the facial nucleus after facial neurorrhaphy...
November 16, 2016: Journal of Chemical Neuroanatomy
https://www.readbyqxmd.com/read/27836487/phosphorylation-mechanisms-in-dopamine-transporter-regulation
#7
REVIEW
James D Foster, Roxanne A Vaughan
The dopamine transporter (DAT) is a plasma membrane phosphoprotein that actively translocates extracellular dopamine (DA) into presynaptic neurons. The transporter is the primary mechanism for control of DA levels and subsequent neurotransmission, and is the target for abused and therapeutic drugs that exert their effects by suppressing reuptake. The transport capacity of DAT is acutely regulated by signaling systems and drug exposure, providing neurons the ability to fine-tune DA clearance in response to specific conditions...
November 8, 2016: Journal of Chemical Neuroanatomy
https://www.readbyqxmd.com/read/27836486/immunochemical-localization-of-vesicular-monoamine-transporter-2-vmat2-in-mouse-brain
#8
Rachel A Cliburn, Amy R Dunn, Kristen A Stout, Carlie A Hoffman, Kelly M Lohr, Alison I Bernstein, Emily J Winokur, James Burkett, Yvonne Shmitz, William M Caudle, Gary W Miller
Vesicular monoamine transporter 2 (VMAT2, SLC18A2) is a transmembrane transporter protein that packages dopamine, serotonin, norepinephrine, and histamine into vesicles in preparation for neurotransmitter release from the presynaptic neuron. VMAT2 function and related vesicle dynamics have been linked to susceptibility to oxidative stress, exogenous toxicants, and Parkinson's disease. To address a recent depletion of commonly used antibodies to VMAT2, we generated and characterized a novel rabbit polyclonal antibody generated against a 19 amino acid epitope corresponding to an antigenic sequence within the C-terminal tail of mouse VMAT2...
November 8, 2016: Journal of Chemical Neuroanatomy
https://www.readbyqxmd.com/read/27826038/title-expression-of-glial-cbp-in-steroid-mediated-neuroprotection-in-male-and-female-zebra-finches
#9
Molly Klores, John T Moon, Kelli A Duncan
Under neurodegenerative conditions, reactive astrocytes upregulate both aromatase (estrogen synthase) as well as estrogen and androgen receptors. This increased steroidogenic signal promotes neuroprotection and repair by promoting neurogenesis and decreasing cell death, but also by modulating the release of inflammatory molecules. Thus, endocrine - immune cross-talk is an essential component of estrogen mediated neuroprotection following brain injury. However, the exact mechanisms underlying this cross-talk remains unknown...
November 5, 2016: Journal of Chemical Neuroanatomy
https://www.readbyqxmd.com/read/27773630/distribution-and-sub-types-of-afferent-fibre-in-the-mouse-urinary-bladder
#10
M S Rahnama'i, B T Biallosterski, Ph E V Van Kerrebroeck, G A van Koeveringe, J I Gillespie, S G de Wachter
AIM: Increased afferent fibre activity contributes to pathological conditions such as the overactive bladder syndrome. Nerve fibres running near the urothelium are considered to be afferent as no efferent system has yet been described. The aim of this study was to identify sub-types of afferent nerve fibres in the mouse bladder wall based on morphological criteria and analyse regional differences. MATERIALS AND METHODS: 27 bladders of six month old C57BL/6 mice were removed and tissues were processed for immunohistochemistry...
October 20, 2016: Journal of Chemical Neuroanatomy
https://www.readbyqxmd.com/read/27771351/the-ontogenetic-development-of-neurons-containing-calcium-binding-proteins-in-the-septum-of-the-guinea-pig-late-onset-of-parvalbumin-immunoreactivity-versus-calbindin-and-calretinin
#11
Beata Hermanowicz-Sobieraj, Anna Robak
The study describes the immunoreactivity of calbindin (CB), calretinin (CR) and parvalbumin (PV), their distribution pattern and the co-distribution of CB and CR as well as CB and PV in the septum of the guinea pig during development. Immunohistochemistry was conducted on embryonic (E40, E50, E60), newborn (P0) and postnatal (P5, P10, P20, P40, P100) guinea pig brains. The presence of both CB and CR was detected at E40, while PV began to be observed at E60. Immunoreactivity for CB was constant throughout ontogeny...
October 19, 2016: Journal of Chemical Neuroanatomy
https://www.readbyqxmd.com/read/27771350/synaptotagmin-7-and-syncrip-proteins-are-ubiquitously-expressed-in-the-rat-brain-and-co-localize-in-purkinje-neurons
#12
Larisa Tratnjek, Marko Živin, Gordana Glavan
Synaptotagmin 7 (SYT7) is ubiquitously expressed calcium sensor, involved in neuronal membrane trafficking. Immunoprecipitation experiments demonstrated that SYT7 interacts with Synaptotagmin-binding, cytoplasmic RNA-interacting protein (SYNCRIP). SYNCRIP is a component of mRNA granules, which are transported to dendrites and are prerequisite for synaptic plasticity. Given the potential significance of SYT7 regulation in processes of neurodegeneration, which are characterized by high level of synaptic vulnerability, we aimed to analyse and compare the distribution of SYT7 and SYNCRIP proteins in the adult rat striatum, hippocampus, cerebral and cerebellar cortex...
October 19, 2016: Journal of Chemical Neuroanatomy
https://www.readbyqxmd.com/read/27641077/interspecies-comparison-of-the-functional-characteristics-of-plasma-membrane-monoamine-transporter-pmat-between-human-rat-and-mouse
#13
Yoshiyuki Shirasaka, Nora Lee, Haichuan Duan, Horace Ho, Joanna Pak, Joanne Wang
Plasma membrane monoamine transporter (PMAT) is a newly discovered monoamine transporter belonging to the equilibrative nucleoside transporter family. Highly expressed in the brain, PMAT represents a major uptake2 transporter that may play a role in monoamine clearance. Although human PMAT has been functionally characterized at the molecular level, rodent models are often used to evaluate PMAT function in ex vivo and in vivo studies. The aim of this study was to examine if there is potential species difference in the functional characteristics of PMAT between human, rat and mouse...
September 15, 2016: Journal of Chemical Neuroanatomy
https://www.readbyqxmd.com/read/27650207/adverse-effects-in-lumbar-spinal-cord-morphology-and-tissue-biochemistry-in-sprague-dawley-male-rats-following-exposure-to-a-continuous-1-h-a-day-900-mhz-electromagnetic-field-throughout-adolescence
#14
Gökçen Kerimoğlu, Ali Aslan, Orhan Baş, Serdar Çolakoğlu, Ersan Odacı
Cell phones, an indispensable element of daily life, are today used at almost addictive levels by adolescents. Adolescents are therefore becoming increasingly exposed to the effect of the electromagnetic field (EMF) emitted by cell phones. The purpose of this study was to investigate the effect of exposure to a 900-MHz EMF throughout adolescence on the lumbar spinal cord using histopathological, immunohistochemical and biochemical techniques. Twenty-four Sprague Dawley (28.3-43.9g) aged 21days were included in the study...
December 2016: Journal of Chemical Neuroanatomy
https://www.readbyqxmd.com/read/27650206/tyrosine-hydroxylase-immunoreactivity-and-its-relations-with-gonadotropin-releasing-hormone-and-neuropeptide-y-in-the-preoptic-area-of-the-guinea-pig
#15
Krystyna Bogus-Nowakowska, Maciej Równiak, Beata Hermanowicz-Sobieraj, Barbara Wasilewska, Janusz Najdzion, Anna Robak
The present study examines the distribution of tyrosine hydroxylase (TH) immunoreactivity and its morphological relationships with neuropeptide Y (NPY)- and gonadoliberin (GnRH)-immunoreactive (IR) structures in the preoptic area (POA) of the male guinea pig. Tyrosine hydroxylase was expressed in relatively small population of perikarya and they were mostly observed in the periventricular preoptic nucleus and medial preoptic area. The tyrosine hydroxylase-immunoreactive (TH-IR) fibers were dispersed troughout the whole POA...
December 2016: Journal of Chemical Neuroanatomy
https://www.readbyqxmd.com/read/27644143/up-regulation-of-neurofilament-light-chains-is-associated-with-diminished-immunoreactivities-for-map2-and-tau-after-ischemic-stroke-in-rodents-and-in-a-human-case
#16
Wolfgang Härtig, Martin Krueger, Sarah Hofmann, Hartmut Preißler, Martin Märkel, Clara Frydrychowicz, Wolf C Mueller, Ingo Bechmann, Dominik Michalski
As stroke therapies are still limited to a minority of patients, efforts have been intensified to an improved understanding of pathophysiological processes during ischemia formation, potentially allowing the development of specific therapeutic interventions. In this context, cytoskeletal elements became evident as key players during the transition process towards long-lasting tissue damage. This study focused on ischemia-related alterations of the cytoskeleton with a special focus on microtubule-associated proteins and neurofilament light chains (NF-L)...
December 2016: Journal of Chemical Neuroanatomy
https://www.readbyqxmd.com/read/27639323/corticotropin-releasing-hormone-crh-immunoreactive-ir-axon-varicosities-target-a-subset-of-growth-hormone-releasing-hormone-ghrh-ir-neurons-in-the-human-hypothalamus
#17
Michael Peroski, Nikoletta Proudan, George Grignol, Istvan Merchenthaler, Bertalan Dudas
It is a general consensus that stress is one of the major factors that suppresses growth. Previous studies revealed that the catecholaminergic and neuropeptide Y (NPY) systems, involved in the activation of stress-related neuronal circuits, influence growth hormone (GH)-release via modulating growth hormone-releasing hormone (GHRH) secretion. Indeed, catecholaminergic and NPY-immunoreactive (IR) axon varicosities abut on the surface of the GHRH neurons forming contacts. These juxtapositions appear to be real synapses and may represent the morphological substrate of the impact of stress on growth...
December 2016: Journal of Chemical Neuroanatomy
https://www.readbyqxmd.com/read/27619060/fluoxetine-prevents-the-memory-deficits-and-reduction-in-hippocampal-cell-proliferation-caused-by-valproic-acid
#18
Jariya Umka Welbat, Preeyanuch Sangrich, Apiwat Sirichoat, Pornthip Chaisawang, Wunnee Chaijaroonkhanarak, Parichat Prachaney, Wanassanun Pannangrong, Peter Wigmore
Valproic acid (VPA), a commonly used antiepileptic drug, has been reported to cause cognitive impairments in patients. In a previous study, using a rodent model, we showed that VPA treatment impaired cognition which was associated with a reduction in the cell proliferation required for hippocampal neurogenesis. The antidepressant fluoxetine has been shown to increase hippocampal neurogenesis and to reverse the memory deficits found in a number of pathological conditions. In the present study we investigated the protective effects of fluoxetine treatment against the impairments in memory and hippocampal cell proliferation produced by VPA...
December 2016: Journal of Chemical Neuroanatomy
https://www.readbyqxmd.com/read/27609084/the-efficacy-of-schwann-cell-transplantation-on-motor-function-recovery-after-spinal-cord-injuries-in-animal-models-a-systematic-review-and-meta-analysis
#19
REVIEW
Mostafa Hosseini, Mahmoud Yousefifard, Masoud Baikpour, Vafa Rahimi-Movaghar, Farinaz Nasirinezhad, Somaye Younesian, Saeed Safari, Parisa Ghelichkhani, Ali Moghadas Jafari
AIM: This article aimed to assess the efficacy of Schwann cell transplantation on motor function recovery in animal model of spinal cord injuries via meta-analysis. METHODS: An extended search was carried out in the electronic databases of Medline (via PubMed), EMBASE (via OvidSP), CENTRAL, SCOPUS, Web of Science (BIOSIS), and ProQuest. Finally, 41 eligible studies conducted on 1046 animals including 517 control animals and 529 transplanted animals were included in the meta-analysis...
December 2016: Journal of Chemical Neuroanatomy
https://www.readbyqxmd.com/read/27600327/localization-of-rem2-in-the-central-nervous-system-of-the-adult-rainbow-trout-oncorhynchus-mykiss
#20
Anna G Downs, Katie R Scholles, David M Hollis
Rem2 is member of the RGK (Rem, Rad, and Gem/Kir) subfamily of the Ras superfamily of GTP binding proteins known to influence Ca(2+) entry into the cell. In addition, Rem2, which is found at high levels in the vertebrate brain, is also implicated in cell proliferation and synapse formation. Though the specific, regional localization of Rem2 in the adult mammalian central nervous system has been well-described, such information is lacking in other vertebrates. Rem2 is involved in neuronal processes where the capacities between adults of different vertebrate classes vary...
December 2016: Journal of Chemical Neuroanatomy
journal
journal
30037
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"