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Journal of Chemical Neuroanatomy

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https://www.readbyqxmd.com/read/29787792/age-dependent-alterations-in-expression-and-co-localization-of-pax6-and-ras-gap-in-brain-of-aging-mice
#1
Khushboo Srivastava, Ratnakar Tripathi, Rajnikant Mishra
As the brain ages, the survival and plasticity of neurons and glia are compromised. The data-mining and in silico studies suggest interactions of Pax6 with Ras and binding sites in Ras-GAP promoter. The Pax6 also shows age-dependent alterations. Therefore, it is presumed that Pax6 may be associated with the Ras-GAP, a synaptic protein, either directly or indirectly in brain. The expression, co-localization and interaction of Pax6 and Ras-GAP in different regions of brain of mice during aging were investigated through immunofluorescence assay, co-immunoprecipitation and western blotting, respectively...
May 19, 2018: Journal of Chemical Neuroanatomy
https://www.readbyqxmd.com/read/29753860/the-modular-architecture-and-neurochemical-patterns-in-the-cerebellar-cortex
#2
REVIEW
Sergei G Kalinichenko, Igor I Pushchin
The review deals with topical issues of the neuronal arrangement underlying basic cerebellar functions. The cerebellum and its auxiliary structures contain several hundreds of modules (so called "microzones"). Each module receives the corticopetal input specific for the lobule it belongs to and forms the topographic projection. The precision of the major input-output signal flow in the cerebellar cortex is provided by a pronounced stratification of its synaptic zones of a various origin and regular topography of its afferent connections, interneurons, and efferent neurons...
May 10, 2018: Journal of Chemical Neuroanatomy
https://www.readbyqxmd.com/read/29702163/transient-global-cerebral-ischemia-differentially-affects-cortex-striatum-and-hippocampus-in-bilateral-common-carotid-arterial-occlusion-bccao-mouse-model
#3
Abhipradnya Bipin Wahul, Pranav Chintamani Joshi, Arvind Kumar, Sumana Chakravarty
Despite the advancements in medical sciences in last few decades, we are yet to develop promising therapeutics for stroke, which is one of the current global non-communicative disease concerns. The occurrence of stroke is likely to increase further due to the transition in our lifestyles. Inadequate knowledge of the sequential region-specific pathological events induced by cerebral ischemia is one of the underlying reasons. Hence to address this, we have used Bilateral Common Carotid Arterial occlusion (BCCAo) model that mimics human cardiac arrest condition...
April 24, 2018: Journal of Chemical Neuroanatomy
https://www.readbyqxmd.com/read/29694843/structural-and-lipid-peroxidation-effects-of-lead-on-rat-hippocampus-and-its-attenuation-by-hydrogen-rich-water
#4
Melad G Paulis, Osama A Hassan, Mohmed F Abbass, Mostafa Abo-Al Hamad Mohammad
Despite the well-known toxicity and the efforts to control its exposure, lead still has a serious health concern, particularly in young ages. Chelation therapy cannot correct the neurocognitive effects of chronic exposure. So, there is a requirement to test different protective agents for lead intoxication. Hydrogen-rich water (HRW) has gained attraction recently as an antioxidant. Four groups of rats received sodium acetate, HRW, lead acetate (LA), or LA plus HRW for 8 weeks. Oxidative stress, histological and immunohistochemistry using p53 antibody were used to investigate the toxic effect of lead and the possible HRW protective effect in rat hippocampus...
April 22, 2018: Journal of Chemical Neuroanatomy
https://www.readbyqxmd.com/read/29694842/baseline-striatal-and-nigral-interneuronal-protein-levels-in-two-distinct-mice-strains-differ-in-accordance-with-their-mptp-susceptibility
#5
Bidisha Bhaduri, P L Abhilash, Phalguni Anand Alladi
Epidemiological studies reveal an ethnicity-based bias in prevalence of Parkinson's disease (PD), deriving from the differences that exist between Caucasians and African or Asian populations. Experimental mice models provide a scope to analyse the cellular mechanisms of differential susceptibility to PD. C57BL/6 J mice, for instance, are more susceptible to MPTP-induced Parkinsonism whereas CD-1 mice are resistant. In PD-pathogenesis, interneuronal contribution is also likely, although they comprise only 5-10% of the striatal cells...
April 22, 2018: Journal of Chemical Neuroanatomy
https://www.readbyqxmd.com/read/29678666/biochemical-deficits-and-cognitive-decline-in-brain-aging-intervention-by-dietary-supplements
#6
REVIEW
Jit Poddar, Munmun Pradhan, Gargi Ganguly, Sasanka Chakrabarti
The aging of brain in the absence of neurodegenerative diseases, usually called non-pathological brain aging or normal cognitive aging, is characterized by an impairment of memory and cognitive functions. The underlying cellular and molecular changes in the aging brain that include oxidative damage, mitochondrial impairment, changes in glucose-energy metabolism and neuroinflammation have been reported widely from animal experiments and human studies. The cognitive deficit of non-pathological brain aging is the resultant of such inter-dependent and reinforcing molecular pathologies which have striking similarities with those operating in Alzheimer's disease which causes progressive, irreversible and a devastating form of dementia and cognitive decline in the elderly people...
April 17, 2018: Journal of Chemical Neuroanatomy
https://www.readbyqxmd.com/read/29678665/the-impact-of-pericytes-on-the-brain-and-approaches-for-their-morphological-analysis
#7
REVIEW
Yaroslav Kolinko, Milena Kralickova, Zbynek Tonar
The interest in investigating brain pericytes is growing due to their diverse influences on neuronal function. While numerous studies have investigated the particular properties and functions of pericytes, complex insight into their functional histology is often lacking. In this work, we review and combine the current knowledge regarding brain pericyte function in normal physiology and its role in the pathogenesis of neurodegenerative diseases and tumorigenesis. Special attention is paid to the interaction between the components of the neurovascular unit...
April 17, 2018: Journal of Chemical Neuroanatomy
https://www.readbyqxmd.com/read/29635018/obscure-but-not-obsolete-perturbations-of-the-frontal-cortex-in-common-between-rodent-olfactory-bulbectomy-model-and-major-depression
#8
REVIEW
Ramamoorthy Rajkumar, Gavin S Dawe
Olfactory bulbectomy (OBX) has been used as a model of depression over several decades. This model presupposes a mechanism that is still not proven in clinical depression. A wealth of clinical literature has focused on the derangements in frontal cortex (prefrontal, orbitofrontal and anterior cingulate cortices) associated with depression. In this comprehensive review, anatomical, electrophysiological and molecular sequelae of bulbectomy in the rodent frontal cortex are explored and compared with findings on brains of humans with major depression...
April 7, 2018: Journal of Chemical Neuroanatomy
https://www.readbyqxmd.com/read/29578075/the-effects-of-maternal-diabetes-and-insulin-treatment-on-neurogenesis-in-the-developing-hippocampus-of-male-rats
#9
Akram Sadeghi, Ebrahim Esfandiary, Javad Hami, Hossein Khanahmad, Zahra Hejazi, Mohammad Mardani, Shahnaz Razavi
Diabetes in pregnancy is associated with an increasing risk of congenital malformations and central nervous system disorders (CNS) especially hippocampal neuronal circuitry disruption as a discreet region involved in neurogenesis phenomenon. This study aimed to investigate the effect of maternal diabetes and insulin treatment on the expression and distribution pattern of NeuN and DCX as two important markers of neurogenesis paradigm in developing rat hippocampus. All animals were randomly divided into three groups as follows: Control group, Diabetic (STZ-D), Diabetic treated with insulin (STZ-INS)...
March 22, 2018: Journal of Chemical Neuroanatomy
https://www.readbyqxmd.com/read/29530792/implication-of-regional-brain-serotonergic-neurons-in-dorsal-and-median-raph%C3%A3-nuclei-in-adaptation-to-water-lacking-in-gerbillus-tarabuli
#10
Houari Boukersi, Nemcha Lebaili, Nathalie Samson, Sylvie Granon
The objective of this work was to investigate the implication of serotonin (5-HT) produced in the dorsal and medial raphé nuclei (DRN and MRN) in water homeostasis in desert animal Gerbillus tarabuli. For that, we measured the density of 5-HT immunolabeled neurons in hydrated and dehydrated animals (over 1 and six months). In this work, 5-HT positive neurons showed some change in shape and colour intensity in dehydrated gerbils comparing with hydrated gerbils. Furthermore a differential increase of 5-HT neurons density was observed in DRN subregions and in MRN following 1 and 6 months of dehydration...
March 9, 2018: Journal of Chemical Neuroanatomy
https://www.readbyqxmd.com/read/29530791/overexpression-of-mir-219-promotes-differentiation-of-human-induced-pluripotent-stem-cells-into-pre-oligodendrocyte
#11
Bahareh Nazari, Masoud Soleimani, Somayeh Ebrahimi-Barough, Seyed Ehsan Enderami, Mansure Kazemi, Babak Negahdari, Esmaeil Sadroddiny, Jafar Ai
Oligodendrocytes play critical roles in the central nervous system (CNS) thorough producing myelin sheaths around axons. There are a variety of approaches to produce oligodendrocytes in vitro and in vivo which are a subject of interest in many studies. A new approach to induce this differentiation is using microRNA 219 (miR-219). However, this new approach suffers from a lack of studies regarding the effect of miR-219 on differentiating human induced pluripotent stem cells (hiPSCs) to oligodendrocytes. This study aimed to assess the impact of miR-219-overexpression on hiPSCs...
March 9, 2018: Journal of Chemical Neuroanatomy
https://www.readbyqxmd.com/read/29501523/the-effect-of-intrathecal-injection-of-irisin-on-pain-threshold-and-expression-rate-of-gabab-receptors-in-peripheral-neuropathic-pain-model
#12
Sima Dameni, Atousa Janzadeh, Mahmoud Yousefifard, Farinaz Nasirinezhad
BACKGROUND: and aim: Irisin is a new myokine that is secreted by myocytes during exercise, and plays a role in creating the beneficial effects of exercise on metabolism. Considering the benefits of exercise in reducing pain, this study was carried out to determine the probable effect of irisin on neuropathic pain in the chronic constriction injury (CCI) model in male rats. METHODS: To induce neuropathic pain CCI model was used. Animals were divided into groups of control, CCI, sham, CCI + vehicle, and CCI + irisin...
March 6, 2018: Journal of Chemical Neuroanatomy
https://www.readbyqxmd.com/read/29499254/mapping-the-protein-phosphorylation-sites-in-human-mitochondrial-complex-i-nadh-ubiquinone-oxidoreductase-a-bioinformatics-study-with-implications-for-brain-aging-and-neurodegeneration
#13
Niya Gowthami, B Sunitha, Manish Kumar, T S Keshava Prasad, N Gayathri, B Padmanabhan, M M Srinivas Bharath
In eukaryotes, mitochondrial complex I (NADH: ubiquinone oxidoreductase; CI) is central to oxidative phosphorylation (OXPHOS). Mammalian CI is a 45 subunit complex that forms supercomplexes with other OXPHOS complexes. Since CI defects are associated with aging and neurodegeneration, it is pertinent to understand its structure-function relationship. Although genetic mutations could lower CI activity causing mitochondrial dysfunction in several pathologies, post-translational modifications (PTMs) have emerged as a key mechanism contributing to altered CI activity...
February 27, 2018: Journal of Chemical Neuroanatomy
https://www.readbyqxmd.com/read/29477446/estrogen-induced-neuroimmunomodulation-as-facilitator-of-and-barrier-to-reproductive-aging-in-brain-and-lymphoid-organs
#14
REVIEW
Srinivasan ThyagaRajan, Lalgi Hima, Uday P Pratap, Hannah P Priyanka, Ramasamy Vasantharekha
Reproductive aging in females is marked by alterations in gonadal hormones, estrogen and progesterone, that facilitate cessation of reproductive cycles and onset of female-specific diseases such as autoimmune and neurodegenerative diseases, hormone-dependent cancers, and osteoporosis. Bidirectional communication between the three homeostatic systems, nervous system, endocrine system, and immune system, is essential for the maintenance of health and any dysfunction in the cross-talk promotes the development of diseases and cancer...
February 27, 2018: Journal of Chemical Neuroanatomy
https://www.readbyqxmd.com/read/29548939/brain-plasticity-from-fundamental-research-to-clinic
#15
EDITORIAL
Yves Tillet, Sylvie Chalon
No abstract text is available yet for this article.
April 2018: Journal of Chemical Neuroanatomy
https://www.readbyqxmd.com/read/29524607/genistein-attenuates-seizure-induced-hippocampal-brain-derived-neurotrophic-factor-overexpression-in-ovariectomized-rats
#16
Mehdi Khodamoradi, Hamed Ghazvini, Saeed Esmaeili-Mahani, Kaveh Shahveisi, Vahid Farnia, Hossein Zhaleh, Nasrin Abdoli, Zeinab Akbarnejad, Hakimeh Saadati, Vahid Sheibani
No abstract text is available yet for this article.
April 2018: Journal of Chemical Neuroanatomy
https://www.readbyqxmd.com/read/29481900/biochemical-markers-of-striatal-desensitization-in-cortical-limbic-hyperglutamatergic-ts-ocd-like-transgenic-mice
#17
Kylie B O'Brien, Anjail Z Sharrief, Eric J Nordstrom, Anthony J Travanty, Mailee Huynh, Megan P Romero, Katie C Bittner, Michael T Bowser, Frank H Burton
Tics and compulsions in comorbid Tourette's syndrome (TS) and obsessive-compulsive disorder (OCD) are associated with chronic hyperactivity of parallel cortico/amygdalo-striato-thalamo-cortical (CSTC) loop circuits. Comorbid TS- & OCD-like behaviors have likewise been observed in D1CT-7 mice, in which an artificial neuropotentiating transgene encoding the cAMP-elevating intracellular subunit of cholera toxin (CT) is chronically expressed selectively in somatosensory cortical & amygdalar dopamine (DA) D1 receptor-expressing neurons that activate cortico/amygdalo-striatal glutamate (GLU) output...
April 2018: Journal of Chemical Neuroanatomy
https://www.readbyqxmd.com/read/29448002/gdf11-expression-in-the-adult-rat-central-nervous-system
#18
Yutaro Hayashi, Sumiko Mikawa, Kazuma Masumoto, Fuminori Katou, Kohji Sato
Growth differentiation factor 11 (GDF11), also known as bone morphogenetic protein 11 (BMP11), is a member of the transforming growth factor β (TGF-β) superfamily. Although GDF11 plays pivotal roles during development, including anterior/posterior patterning, formation of the kidney, stomach, spleen and endocrine pancreas, little information is available for GDF11 expression in the adult central nervous system (CNS). We, thus, investigated GDF11 expression in the adult rat CNS using immunohistochemistry. GDF11 was intensely expressed in most neurons and their axons...
April 2018: Journal of Chemical Neuroanatomy
https://www.readbyqxmd.com/read/29407461/co-localization-patterns-of-neurotensin-receptor-1-and-tyrosine-hydroxylase-in-brain-regions-involved-in-motivation-and-social-behavior-in-male-european-starlings
#19
Devin P Merullo, Jeremy A Spool, Changjiu Zhao, Lauren V Riters
Animals communicate in distinct social contexts to convey information specific to those contexts, such as sexual or agonistic motivation. In seasonally-breeding male songbirds, seasonal changes in day length and increases in testosterone stimulate sexually-motivated song directed at females for courtship and reproduction. Dopamine and testosterone may act in the same brain regions to stimulate sexually-motivated singing. The neuropeptide neurotensin, acting at the neurotensin receptor 1 (NTR1), can strongly influence dopamine transmission...
April 2018: Journal of Chemical Neuroanatomy
https://www.readbyqxmd.com/read/29154915/cocaine-and-amphetamine-regulated-transcript-peptide-and-calcium-binding-proteins-immunoreactivity-in-the-deep-layers-of-the-superior-colliculus-of-the-guinea-pig-implications-for-multisensory-and-visuomotor-processing
#20
Janusz Najdzion
The superior colliculus (SC) of mammals is a midbrain center, that can be subdivided into the superficial (SCs) and deep layers (SCd). In contrast to the visual SCs, the SCd are involved in multisensory and motor processing. This study investigated the pattern of distribution and colocalization of cocaine- and amphetamine-regulated transcript peptide (CART) and three calcium-binding proteins (CaBPs) i.e. calbindin (CB), calretinin (CR) and parvalbumin (PV) in the SCd of the guinea pig. CART labeling was seen almost exclusively in the neuropil and fibers, which differed in regard to morphology and location...
March 2018: Journal of Chemical Neuroanatomy
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