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Head & Neck

Susanne Singer, Cecilie Delphin Amdal, Eva Hammerlid, Iwona M Tomaszewska, Joaquim Castro Silva, Hisham Mehanna, Marcos Santos, Johanna Inhestern, Christine Brannan, Noam Yarom, Amy Fullerton, Monica Pinto, Juan I Arraras, Naomi Kiyota, Pierluigi Bonomo, Allen C Sherman, Ingo Baumann, Razvan Galalae, Loreto Fernandez Gonzalez, Ourania Nicolatou-Galitis, Zeinab Abdel-Hafeez, Judith Raber-Durlacher, Claudia Schmalz, Paola Zotti, Andreas Boehm, Dirk Hofmeister, Sanja Krejovic Trivic, Suat Loo, Wei-Chu Chie, Kristin Bjordal, Bente Brokstad Herlofson, Vincent Grégoire, Lisa Licitra
BACKGROUND: We validated the new European Organisation for Research and Treatment of Cancer Quality of Life Head and Neck Module (EORTC QLQ-HN43). METHODS: We enrolled 812 patients with head and neck cancer from 18 countries. Group 1 completed the questionnaire before therapy, and 3 and 6 months later. In group 2 (survivors), we determined test-retest reliability using intraclass correlation coefficients (ICC). Internal consistency was assessed using Cronbach's Alpha, the scale structure with confirmatory factor analysis, and discriminant validity with known-group comparisons...
January 12, 2019: Head & Neck
Hideyuki Takahashi, Koichi Sakakura, Hiroe Tada, Kyoichi Kaira, Tetsunari Oyama, Kazuaki Chikamatsu
BACKGROUND: Several inflammatory biomarkers are considered potential prognostic factors in various cancers. This study aimed to investigate the prognostic significance and population dynamics of pretreatment inflammatory biomarker levels in patients with oropharyngeal squamous cell carcinoma (OPSCC). METHODS: The influence of neutrophil counts, lymphocyte counts, monocyte counts, platelet counts, lymphocyte-to-monocyte ratio (LMR), neutrophil-to-lymphocyte ratio, and platelet-to-lymphocyte ratio on progression-free survival (PFS), and overall survival (OS) was analyzed...
January 12, 2019: Head & Neck
Juan P Rodrigo, Fabian García-Velasco, Petra Ambrosch, Vincent Vander Poorten, Carlos Suárez, Andrés Coca-Pelaz, Primoz Strojan, Kate Hutcheson, Benedikt J Folz, Manuel Bernal-Sprekelsen, Alessandra Rinaldo, Carl E Silver, Alfio Ferlito
BACKGROUND: Data about the results of transoral laser microsurgery (TLM) in elderly patients are limited. METHODS: A retrospective study of 72 consecutive cases of glottic carcinoma (63 pT1 and 9 pT2 cases) in elderly patients (≥70 years old, mean 76 years) treated with TLM was made. A systematic review of the literature was performed. RESULTS: Six patients (8%) had postoperative complications, but no treatment-related deaths were observed...
January 12, 2019: Head & Neck
Jeong Won Lee, Myung Jin Ban, Jae Hong Park, Sang Mi Lee
BACKGROUND: The aim of this study was to evaluate the relationship of the characteristics of subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT) to the disease progression-free survival and distant failure-free survival of head and neck squamous cell carcinoma (HNSCC). METHODS: We enrolled 152 HNSCC patients who underwent staging 18 F-fluorodeoxyglucose (FDG) positron emission tomography/CT (PET/CT). Maximum FDG uptake (standardized uptake value [SUV]) and total lesion glycolysis (TLG) of the primary tumor and volume, CT-attenuation (Hounsfield units [HU]), and FDG uptake of SAT and VAT were measured...
January 12, 2019: Head & Neck
Chia-Jui Yen, Hsiao-Hui Tsou, Ching-Yun Hsieh, Chang-Yao Chu, Chang-Fang Chiu, Chih-Cheng Chen, Chao-Jung Tsao, Kuo-Yang Tsai, Sen-Tien Tsai, Jang-Yang Chang, Kwang-Yu Chang
BACKGROUND: The prognosis of advanced oral squamous cell carcinoma is poor. We investigated the effect of cetuximab-based sequential therapy as a primary treatment. METHODS: Forty-seven treatment-naive patients with advanced tumors originating from the oral cavity or oropharynx were enrolled. Neoadjuvant cetuximab, paclitaxel, and cisplatin were administered, followed by cetuximab-based radiotherapy. Immunohistochemical staining was applied to study the tissues...
January 12, 2019: Head & Neck
Davide Mattavelli, Marco Ferrari, Andrea Bolzoni Villaret, Alberto Schreiber, Vittorio Rampinelli, Mario Turri-Zanoni, Davide Lancini, Valentina Taglietti, Remo Accorona, Francesco Doglietto, Paolo Battaglia, Paolo Castelnuovo, Piero Nicolai
BACKGROUND: In nasal-ethmoidal malignancies, brain involvement is associated with dismal prognosis. METHOD: Patients undergoing endoscopic resection with transnasal craniectomy and subpial dissection (ERTC-SD) for brain-invading nasal-ethmoidal cancer between 2008 and 2016 were included. Complications were analyzed in all patients, whereas oncological outcomes only in patients with pathological brain invasion. The prognostic impact of previous treatments, brain edema, and histology was assessed...
January 12, 2019: Head & Neck
Sarah Baker, Gerda Verduijn, Steven Petit, Joost J Nuyttens, Aniel Sewnaik, Aad van der Lugt, Wilma D Heemsbergen
BACKGROUND: To investigate the location of recurrences with respect to the radiation fields in oropharynx cancer after intensity-modulated radiotherapy and stereotactic body radiotherapy (SBRT) boost. METHODS: Local and regional recurrences were delineated on diagnostic scans which were rigidly coregistered with treatment planning scans, then classified based on the location of the center of mass (COM) as well as volumetrically. RESULTS: In 195 patients, the 5-year local and regional control were 90% and 93%, respectively...
January 12, 2019: Head & Neck
Antoine Schernberg, Charles Canova, Pierre Blanchard, Philippe Gorphe, Ingrid Breuskin, Haitham Mirghani, Antoine Moya-Plana, François Janot, Francois Bidault, Cyrus Chargari, Sara Bellefqih, Amandine Ruffier, Caroline Even, France Nguyen, Stéphane Temam, Yungan Tao
BACKGROUND: To define the prognostic factors associated with outcome in patients with soft palate squamous cell carcinoma (SCC). METHODS: Previously untreated patients with soft palate and uvula SCC treated in our institution between 1997 and 2012 were collected. The prognostic value of clinical, hematological, and treatment characteristics was examined. RESULTS: We identified 156 patients, median age 58 years, with 71% drinkers, 91% smokers; 19% had synchronous cancer...
January 12, 2019: Head & Neck
Rui Chen, Zhi-Quan Huang, Wei-Liang Chen, Zhan-Peng Ou, Shi-Hao Li, Jian-Guang Wang
BACKGROUND: The aim of this study was to investigate the value of a smartphone-compatible thermal imaging camera in the mapping of the peroneal artery perforators. METHODS: Twelve consecutive patients scheduled for fibular flap reconstruction were enrolled. The lower limbs were first studied using smartphone-based dynamic infrared thermography (DIRT). During the rewarming, the hotspots were marked, small rubber markers were taped to the registered sites, and then the patients were sent for a CT scan...
January 12, 2019: Head & Neck
Yasmin Lassen-Ramshad, Enis Ozyar, Senem Alanyali, Philip Poortmans, Paul van Houtte, Schoeb Sohawon, Mustafa Esassolak, Marco Krengli, Salvador Villa, Robert Miller, Candan Demiroz, Serap Akyurek, Ninna Aggerholm-Pedersen, Juliette Thariat
BACKGROUND: Paraganglioma of the head and neck (HNPGL) are rare often benign tumors. Surgery and radiation therapy (RT) are the main treatment choices. We present an analysis of outcome and toxicity after RT from 13 institutions of the Rare Cancer Network. METHODS: Data were collected using a questionnaire concerning patients' characteristics, treatment, and outcome. A total of 81 patients with 82 HNPGL were analyzed. RESULTS: The median follow-up was 48 months (1-456)...
January 11, 2019: Head & Neck
Benjamin R Campbell, Courtney B Sanders, James L Netterville, Robert J Sinard, Sarah L Rohde, Alexander Langerman, Kyle Mannion, Young J Kim, Barbara A Murphy, James S Lewis, Jeremy L Warner, Derek K Smith, Krystle A Lang Kuhs
BACKGROUND: Incidence of oral tongue squamous cell carcinoma (OTC) is rising among those under age 50 years. The etiology is unknown. METHODS: A total of 395 cases of OTC diagnosed and/or treated at Vanderbilt University Medical Center between 2000 and 2017 were identified. Of those, 113 (28.6%) were early onset (age < 50 years). Logistic regression was used to identify factors associated with early onset OTC. Cox proportional hazards models evaluated survival and recurrence...
January 11, 2019: Head & Neck
Thomas H Beckham, Jonathan Leeman, Chiaojung Jillian Tsai, Nadeem Riaz, Eric Sherman, Bhuvanesh Singh, Nancy Lee, Sean McBride, Daniel S Higginson
BACKGROUND: Fanconi anemia (FA) is associated with an increased risk of developing head and neck squamous cell cancer (HNSCC) and presents a treatment dilemma due to concerns of increased toxicities from chemotherapy and radiation therapy (RT). METHODS: We reviewed the literature on HNSCC in FA patients and report on our experience treating 9 FA patients with HNSCC. RESULTS: Surgery was generally well-tolerated and surgery alone resulted in durable local control for 2 patients...
January 11, 2019: Head & Neck
Turang E Behbahani, Eben L Rosenthal, William B Parker, Eric J Sorscher
This report describes treatment of locoregional head and neck squamous cell carcinoma (HNSCC) by an innovative, experimental strategy involving generation of a robust anti-cancer agent (2-fluoroadenine [F-Ade]) following transduction by Escherichia coli purine nucleoside phosphorylase (PNP) in a small number of tumor cells. F-Ade works by a unique mechanism of action (ablation of RNA and protein synthesis) and confers tumor regressions of otherwise refractory HNSCC in human subjects. Clinical studies have now advanced to a pivotal (registration-directed) trial involving locoregional HNSCC, with plans to begin subject enrollment late in 2018...
January 11, 2019: Head & Neck
Maria Grosheva, Carina Pick, Thordis Granitzka, Barbara Sommer, Claus Wittekindt, Jens Peter Klussmann, Orlando Guntinas-Lichius, Dirk Beutner
BACKGROUND: In this prospective nonrandomized multicenter trial, we analyze the incidence of early and late complications after parotidectomy in correlation to the extent of dissection. METHODS: A total of 148 patients underwent a parotidectomy for a benign lesion in the superficial lobe. The number of intraoperatively dissected main facial nerve branches was photo-documented and defined the extent of tissue dissection. Early postoperative complications including sialocele were evaluated until 4 weeks after surgery...
January 11, 2019: Head & Neck
Yasuhiro Ebihara, Saori Yoshida, Mitsuhiko Nakahira, Yasunao Kogashiwa, Yuichiro Enoki, Kiyomi Kuba, Hitoshi Inoue, Kazuhiko Minami, Masanori Yasuda, Masashi Sugasawa
BACKGROUND: Factors involved in neck lymph node metastasis (NLM) and prognosis of early tongue squamous cell carcinoma (SCC) remain unknown. METHODS: We analyzed disease-specific survival (DSS) and NLM including tumor budding grade (TBG) among 64 patients with cT1/2N0 tongue SCC. RESULTS: Univariate analysis of DSS of primary lesions uncovered significant differences in new cT, pT, new pT, pDiameter, venous infiltration, and TBG. Multivariate analysis selected only TBG3 as a predictor of NLM (odds ratio, 9...
January 11, 2019: Head & Neck
Jason W Chan, Iwei Yeh, Ivan H El-Sayed, Alain P Algazi, Christine M Glastonbury, Patrick K Ha, Sue S Yom, Annemieke van Zante
BACKGROUND: Head and neck squamous cell carcinoma of unknown primary site (HNSCCUP) is a diagnostic challenge. Identification of an ultraviolet (UV) light-related DNA damage signature using next-generation sequencing (NGS) can classify the primary site of origin as cutaneous. METHODS: A 62-year-old male was seen with 2 months of left neck swelling. He was a lifetime nonsmoker but had a history of cutaneous squamous cell carcinoma (SCC) of the left helix. He was also found to have left hilar adenopathy...
January 11, 2019: Head & Neck
Wenjie Yu, Yu Dou, Ketao Wang, Yanguo Liu, Jintang Sun, Han Gao, Shaohua Liu, Fengcai Wei, Daoying Yuan, Xiaobin Song, Xun Qu
BACKGROUND: To evaluate the prognostic value of preoperative neutrophil lymphocyte ratio (NLR) and platelet lymphocyte ratio (PLR) in oral, pharyngeal, and lip cancer for survival and relapse. METHODS: Clinic-pathologic and hematological records were retrospectively retrieved. Patients completed follow-up period were included for survival and relapse analysis. RESULTS: The preoperative NLR value was a prognostic factor for both overall survival and relapse-free survival...
January 11, 2019: Head & Neck
Xinmao Song, Shengzi Wang, Jie Wang, Weifang Wang, Shuyi Wang, Gang Yang, Ji Li, Yi Zhu, Fu Chen, Wenjia Zhu
BACKGROUND: To investigate the management and outcomes of patients with lacrimal sac squamous cell carcinoma (SCC). METHODS: This retrospective study examined 69 lacrimal sac SCC cases treated at our hospital between 1992 and 2017. The potential risk factors for prognosis, a new staging method, treatment outcomes, and complications were investigated. RESULTS: The 5-year overall survival (OS) and progression-free survival (PFS) were 87.6 ± 4...
January 10, 2019: Head & Neck
Arya W Namin, Georgeanne E Cornell, Lori A Thombs, Robert P Zitsch
BACKGROUND: The objective of this study was to determine survival outcomes in patients who underwent retreatment of recurrent cases of cutaneous melanoma of the head and neck (CMHN). METHODS: Retrospective review of all patients who were treated for primary clinical stage I or II CMHN between January 1, 2000 and December 31, 2015. RESULTS: Twenty percent (33/168) of the patients developed a recurrence. Sixty-six percent (4/6) of patients who developed local recurrence first and 50% (3/6) of patients who developed regional recurrence first were alive without evidence (NED) of disease at last follow-up, while 0% (0/21) of patients who developed distant or simultaneous recurrences first were NED at last follow-up...
January 10, 2019: Head & Neck
Craig A Bollig, Jeffrey B Jorgensen
BACKGROUND: The effect of treatment modality on long-term opioid dependence in patients with oropharyngeal cancer has not been reported. METHODS: A retrospective cohort of 122 patients with T1/T2 oropharyngeal cancer undergoing treatment was generated. Risk factors associated with chronic opioid use were investigated by univariate and multivariate analyses. RESULTS: The prevalence of chronic opioid use was 45.9%. On multivariate analysis, primary nonsurgical treatment (odds ratio [OR] 4...
January 10, 2019: Head & Neck
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