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Head & Neck

Angela T Truong, Dam-Thuy Truong, Thomas F Rahlfs
No abstract text is available yet for this article.
November 2, 2018: Head & Neck
Flavia Sirotheau Correa Pontes, Lucas Lacerda de Souza, Daniel Cavalléro Colares Uchôa, Andrea Maia Correa Joaquim, Liliane Silva do Nascimento, Diogo Dos Santos da Mata Rezende, Hélder Antônio Rebelo Pontes
The aim of the present study was to integrate the available data published on melanotic neuroectodermal tumor of infancy (MNTI) of the jaw bones. An electronic search was undertaken in April 2018. Hundred forty-seven publications and 371 patients were included. The lesion was more prevalent in males and in the second to sixth months of life. The lesions mostly presented as a rapidly growing bluish swelling and the most commonly involved was the anterior maxilla. The mean follow-up was 51.1 months (range 1-408 months)...
November 2, 2018: Head & Neck
Xia Zhang, Changfu Sun, Xiaofeng Bai, Qian Zhang
BACKGROUND: We evaluated the utility of combined femoral and common peroneal nerve blocks in patients undergoing free fibular flap-based oromandibular reconstruction. METHODS: Forty patients undergoing reconstructive surgeries with free fibular flaps were randomly divided into nerve block and control groups (NB and C). In group NB, both femoral and common peroneal nerve blocks with 0.33% ropivacaine were used. In group C, sham blocks were performed with saline. The primary outcomes were sufentanyl consumption during the 0- to 24-hour and 24-to 48-hour intervals and cumulative consumption during the 48-hour postoperative period...
November 2, 2018: Head & Neck
Kamran Habib Awan, Rachana Hegde, Val J Cheever, William Carroll, Shahrukh Khan, Shankargouda Patil, Saman Warnakulasuriya
BACKGROUND: Oral and pharyngeal cancers (OPC) represent the seventh most common type of cancer and the seventh leading cause of deaths by cancer worldwide. Few studies have assessed the occupational exposure risks associated with OPC and in many cases the results are conflicting. The aim of this study was to determine, through a systematic review, the association of OPC and exposure to different occupational carcinogenic substances. METHODS: The addressed focused question was "Is there an association of occupational carcinogenic substances with OPC?" PubMed, MEDLINE, EMBASE, and ISI Web of Science databases were searched between January 1995 up to and including July 2016 using the keywords "oral cancer," "pharyngeal cancer," "pharyngeal neoplasms," "oral neoplasms," "occupational disease," "occupational exposure," and "occupational risk factor" in various combinations...
November 2, 2018: Head & Neck
Jianlin Liu, Yanzi Li, Lin Yang, Hui Cai
BACKGROUND: The purpose of this study was to investigate the outcomes of surgical resection of carotid body tumors with and without preoperative embolization. METHODS: There were 31 patients who underwent surgical resection combined with preoperative embolization (SRE group), and 27 patients who underwent conventional surgical resection (SR group); all clinical data were included and reviewed. RESULTS: There was no difference in the approach for carotid reconstruction in either group (P > ...
November 2, 2018: Head & Neck
Narayana Subramaniam, Deepak Balasubramanian, Tsu-Hui Hubert Low, Samskruthi Murthy, Adharsh Anand, Chaya Prasad, Smitha N Vijayan, Krishnakumar Thankappan, Subramania Iyer
BACKGROUND: The purpose of this study was to determine the factors affecting local control in patients with T1N0 squamous cell carcinoma (SCC) of the tongue. METHODS: We conducted a retrospective analysis of 144 patients with pT1N0 SCC of the tongue who underwent wide excision and neck dissection without adjuvant therapy. RESULTS: The adverse pathological features associated with local control were least margin 5 mm (P = .004), infiltrative margin (P = ...
November 1, 2018: Head & Neck
Ryuji Yasumatsu, Takafumi Nakano, Masanobu Sato, Rina Jiroumaru, Kazuki Hashimoto, Ryunosuke Kogo, Takahiro Wakasaki, Torahiko Nakashima, Takashi Nakagawa
BACKGROUND: Differentiating inverted papilloma from squamous cell carcinoma (SCC) is sometimes difficult. We evaluated the clinical usefulness of serum SCCA1 and SCCA2 in the management of patients with inverted papilloma or SCC. METHODS: Serum and tissue samples for the analysis of SCCA1, SCCA2, and SCC antigen were taken from 18 patients with sinonasal inverted papilloma and 23 cases with sinonasal SCC. The SCCA1, SCCA2, and SCC antigen levels were determined...
October 30, 2018: Head & Neck
J Hans L P Kuijpens, Marieke W J Louwman, Robert Takes, Piet J Slootweg, Alex Burdorf, Boukje A C van Dijk
BACKGROUND: Long-term trends of sinonasal cancer in The Netherlands have been investigated with particular attention on adenocarcinoma for which wood or leather dust is a well-known risk factor. METHODS: All 4345 patients (1989-2014) registered in the Netherlands Cancer Registry were included. Standardized 3-year moving incidence rates per 1 000 000/person-years, and estimated annual percentage change (EAPC) were calculated. RESULTS: Forty-seven percent of the patients had squamous cell carcinoma (SCC), 12% had lymphoma, and 12% had adenocarcinoma...
October 15, 2018: Head & Neck
Natalia Sanz-Gómez, Ana Freije, Laura Ceballos, Sergio Obeso, J Ramón Sanz, Fe García-Reija, Carmelo Morales-Angulo, Alberto Gandarillas
BACKGROUND: Squamous epithelia of the head and neck undergo continuous cell renewal and are continuously exposed to mutagenic hazard, the main cause of cancer. How they maintain homeostasis upon cell cycle deregulation is unclear. METHODS: To elucidate how head and neck epithelia respond to cell cycle stress, we studied human keratinocytes from various locations (oral mucosa, tonsil, pharynx, larynx, and trachea). We made use of genotoxic or mitotic drugs (doxorubicin [DOXO], paclitaxel, and nocodazole), or chemical inhibitors of the mitotic checkpoint kinases, Aurora B and polo-like-1...
October 12, 2018: Head & Neck
Lukas Anschuetz, Miranda Visini, Mohamed Shelan, Olgun Elicin, Roland Giger
BACKGROUND: A tracheostomy has an enormous negative impact on the patient's quality of life. The purpose of this study is to describe risk factors for permanent tracheostomies in patients undergoing curative organ-preserving treatment of laryngeal cancer. METHODS: The charts of all patients with laryngeal cancer diagnosed at our tertiary referral center were reviewed. Cases receiving a tracheostomy before, during, or after primary organ-preserving treatment were eligible...
October 11, 2018: Head & Neck
Xavier León, Laura Pardo, Aina Sansa, Alejandro Fernández, Valle Camacho, Jacinto García, Montserrat López, Miquel Quer
BACKGROUND: The purpose of this study is to evaluate the prognostic significance of nodes with extracapsular spread (ECS) in patients treated with a planned neck dissection after chemoradiotherapy. METHODS: We carried out a retrospective study of 109 cN+ patients who achieved a complete response in the primary location after chemoradiotherapy and treated with a planned neck dissection. RESULTS: The 5-year disease-specific survival for patients without residual metastatic nodes in the neck dissection (pN0, n = 69) was 75...
October 11, 2018: Head & Neck
Na Zhang, Richard Fielding, Inda Soong, Karen Kk Chan, Conrad Lee, Alice Ng, Wing Kin Sze, Janice Tsang, Victor Lee, Wendy Wing Tak Lam
BACKGROUND: Leventhal's commonsense model implies illness perceptions influence illness outcomes. This study examined illness perceptions among head and neck cancer survivors, and whether these predicted subsequent psychological distress. METHODS: A total of 124 survivors of head and neck cancer (87% nasopharyngeal carcinoma; NPC) completed measures of psychological distress (Hospital Anxiety and Depression Scale; HADS), illness perceptions (Brief Illness Perception Questionnaire; B-IPQ), dispositional optimism (revised Chinese version of the Life Orientation Test; C-LOT-R), and clinical and demographic data approximately12...
October 11, 2018: Head & Neck
Samuel N Helman, Jason A Brant, Sameep K Kadakia, Jason G Newman, Steven B Cannady, Raymond L Chai
BACKGROUND: There is little population-level data evaluating risk factors for postoperative complications after total laryngectomy. METHODS: We conducted a retrospective review of the American College of Surgeons National Quality Improvement Program identifying patients who underwent total laryngectomy as a primary procedure from 2005 to 2014. Multivariate analysis was performed to identify variables that were independently associated with overall and major complications...
October 11, 2018: Head & Neck
Suat Kılıç, Sarah S Kılıç, Wayne D Hsueh, Jean Anderson Eloy, Soly Baredes, Richard Chan Woo Park, Omar Mahmoud
BACKGROUND: The impact of radiotherapy (RT) modality and dose on survival in hypopharyngeal cancer managed with definitive RT is unclear. METHODS: The National Cancer Database was queried for patients with hypopharyngeal squamous cell carcinoma (HPSCC) treated with definitive RT. Intensity-modulated radiotherapy (IMRT) was compared with other RT techniques. Clinicopathologic variables, RT modality, and dose impact on overall survival (OS) were assessed using log-rank test and Cox proportional hazard models...
October 10, 2018: Head & Neck
Jae Ryung Lee, Jong-Lyel Roh, Sun Mi Lee, Yangsoon Park, Kyung-Ja Cho, Seung-Ho Choi, Soon Yuhl Nam, Sang Yoon Kim
BACKGROUND: This study analyzed the expression of CD44 and cystine-glutamate transporter SLC7A11 (xCT) in primary oral cavity squamous cell carcinoma (SCC) and the relationships of expression to tumor recurrence and patient survival. METHODS: Associations between CD44 and xCT expression and clinicopathologic results were analyzed in 231 patients with oral cavity SCC. Cox proportional hazard analyses were used to identify factors associated with recurrence-free survival (RFS), disease-specific survival (DSS), and overall survival (OS)...
October 10, 2018: Head & Neck
Michael J Persky, Mohamad Issa, Jennifer R Bonfili, Neerav Goyal, David Goldenberg, Umamaheswar Duvvuri
BACKGROUND: This multicenter, retrospective review documents the initial experience using the Flex system for transoral surgery in 2 United States academic centers. METHODS: All patients who underwent transoral robotic surgery using the Medrobotics Flex Robotic System (Raynham, MA) between September 2015 and May 2017 were reviewed. Rates of successful surgery and complications were evaluated. RESULTS: Thirty-six men and 32 women were enrolled in the study...
October 10, 2018: Head & Neck
Ho Jin Son, Jeong Kyu Kim, Young Do Jung, Gyu Ho Jang, Youn Tae Seo, Deok Su Kim, Sung Hwan Park, Young Ju Jeong
BACKGROUND: There have been arguments over the efficacy of elective unilateral central neck dissection (CND) in patients with papillary thyroid carcinoma (PTC) <1 cm who underwent hemithyroidectomy. This study was designed to investigate locoregional recurrence and postoperative complications related to elective unilateral CND for papillary thyroid microcarcinoma (PTMC). METHODS: Five hundred thirty-seven patients who underwent hemithyroidectomy, with or without CND for PTMC, were included...
October 10, 2018: Head & Neck
Yasunao Kogashiwa, Hitoshi Inoue, Kiyomi Kuba, Ryuichiro Araki, Masanori Yasuda, Mitsuhiko Nakahira, Masashi Sugasawa
BACKGROUND: Cetuximab combined with chemoradiotherapy is the standard therapy for recurrent/metastatic head and neck squamous cell carcinoma (HNSCC). However, survival benefit is limited. The purpose of this study was to investigate the expression of epiregulin (EREG) and amphiregulin (AREG), as predictive prognostic markers for the efficacy of cetuximab combined with chemotherapy in R/M HNSCC. METHODS: We conducted a retrospective analysis of 37 patients diagnosed with R/M HNSCC...
October 10, 2018: Head & Neck
Petar Suton, Marin Prpic, Marko Tarle, Matija Mamic, Iva Nikles, Ivica Luksic
BACKGROUND: The purpose of our article was to describe a tertiary center's experience with patients with primarily surgically treated early-stage intraoral cancer with a second primary malignancy confirmed during follow-up. METHODS: A total of 183 patients were primarily surgically treated for oral cancer between 2000 and 2004. Among these, 24 patients (13.1% (24/183)) met inclusion criteria. RESULTS: There were 22 men (91.7%) and 2 women (8...
October 10, 2018: Head & Neck
Sarah Nicole Hamilton, Eric Tran, Eric Berthelet, Jonn Wu, Robert Olson
BACKGROUND: A retrospective, population-based analysis of 90-day mortality in patients with squamous cell carcinoma of the head and neck treated with radiotherapy was performed to determine the early mortality rate and associated risk factors. METHODS: Data were abstracted for all consecutive patients with cancer of the head and neck treated from 1998 to 2014 at the BC Cancer Agency with curative intent radiotherapy (n = 5658). Logistic regression analysis was used to determine factors associated with early mortality...
October 8, 2018: Head & Neck
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