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Head & Neck

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https://www.readbyqxmd.com/read/28079945/systematic-review-of-site-distribution-of-bone-metastases-in-differentiated-thyroid-cancer
#1
REVIEW
Marcela Osorio, Sami P Moubayed, Henry Su, Mark L Urken
BACKGROUND: Thyroid cancer is the fastest growing cancer in the United States. A small portion of differentiated thyroid cancers (DTCs; 2% to 13%) develop bone metastases, which can decrease a patient's survival rate by more than 60%. METHODS: A systematic literature search of studies, including patients with DTC with bone metastases, was conducted by following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. A case series of patients with DTC diagnosed with bone metastases seen at our institution was also included...
January 11, 2017: Head & Neck
https://www.readbyqxmd.com/read/28075517/neutrophil-to-lymphocyte-ratio-prognostic-indicator-for-head-and-neck-squamous-cell-carcinoma
#2
Nicholas Rosculet, Xian Chong Zhou, Patrick Ha, Mei Tang, Marshall A Levine, Geoffrey Neuner, Joseph Califano
BACKGROUND: The neutrophil-to-lymphocyte ratio (NLR) has prognostic significance for many cancers, with higher values correlating with poor outcomes. The purpose of this study was to determine the prognostic significance of this inflammatory marker for patients with head and neck squamous cell carcinoma (HNSCC). METHODS: Univariate logistic regression and multivariate Cox regression analyses were performed on a retrospective cohort of 123 patients treated with primary chemoradiotherapy...
January 11, 2017: Head & Neck
https://www.readbyqxmd.com/read/28075511/postoperative-iodine-125-interstitial-brachytherapy-for-the-early-stages-of-minor-salivary-gland-carcinomas-of-the-lip-and-buccal-mucosa-with-positive-or-close-margins
#3
Wen-Jie Wu, Xiao Shao, Ming-Wei Huang, Xiao-Ming Lv, Xin-Na Zhang, Jian-Guo Zhang
BACKGROUND: The purpose of this study was to present our preliminary exploration of safety and efficacy of postoperative low-dose-rate brachytherapy for the early clinical stages of minor salivary gland carcinomas of the lip and buccal mucosa. METHODS: Twenty-seven patients with the early stages of minor salivary gland carcinomas of the lip and buccal mucosa received postoperative (125) I seed interstitial brachytherapy from March 2005 to May 2015. Actuarial likelihood estimates for local control, overall survival, and disease-free survival were calculated by Kaplan-Meier method...
January 11, 2017: Head & Neck
https://www.readbyqxmd.com/read/28072490/reply-regarding-prognostic-value-of-neutrophil-to-lymphocyte-ratio-in-laryngeal-squamous-cell-carcinoma
#4
LETTER
B Y Winson Wong, Nicholas D Stafford, Victoria L Green, John Greenman
No abstract text is available yet for this article.
January 10, 2017: Head & Neck
https://www.readbyqxmd.com/read/28072484/letter-to-the-editor-regarding-neutrophil-to-lymphocyte-ratio-in-laryngeal-squamous-cell-carcinoma
#5
LETTER
Satvinder Singh Bakshi
No abstract text is available yet for this article.
January 10, 2017: Head & Neck
https://www.readbyqxmd.com/read/28067982/sensation-loss-after-superficial-parotidectomy-a-prospective-controlled-multicenter-trial
#6
Maria Grosheva, Sami Shabli, Gerd Fabian Volk, Barbara Sommer, Laura Ludwig, Mira Finkensieper, Claus Wittekindt, Jens Peter Klussmann, Orlando Guntinas-Lichius, Dirk Beutner
BACKGROUND: The purpose of this study was to evaluate the occurrence of hypoesthesia after superficial parotidectomy depending on preservation of posterior branch of the great auricular nerve (GAN). METHODS: This prospective, controlled, double blind, multicenter trial included 130 patients. The posterior branch was preserved in 93 patients (GAN group), and ligated in 33 patients (non-GAN group). In 4 patients, GAN status was unknown. Included patients underwent sensory testing (TouchTest) and subjective evaluation at 6, 12, and 24 months after surgery...
January 9, 2017: Head & Neck
https://www.readbyqxmd.com/read/28067974/prognostic-value-of-the-seventh-ajcc-uicc-tnm-classification-of-intestinal-type-ethmoid-adenocarcinoma-systematic-review-and-risk-prediction-model
#7
Domitille Fiaux-Camous, Sylvie Chevret, Natalie Oker, Mario Turri-Zanoni, Davide Lombardi, Olivier Choussy, Duprez Frederic, Marc Jorissen, Ludovic de Gabory, Olivier Malard, Philippe Herman, Piero Nicolai, Paolo Castelnuovo, Frederic Duprez Benjamin Verillaud
BACKGROUND: The purpose of this study was to propose a prognostic classification of intestinal-type adenocarcinoma (ITAC) based on literature search and prognostic modeling of cohort data. METHODS: We first conducted a literature search to assess the homogeneity of the reported estimates of 5-year survival and to identify the influence of T classification. We then pooled prospective data from 3 large French and Italian series to predict time to all-cause mortality...
January 9, 2017: Head & Neck
https://www.readbyqxmd.com/read/28067972/single-innervated-segmented-vastus-lateralis-for-midfacial-reanimation-during-radical-parotidectomy
#8
Lauren Sh Chong, Timothy J Eviston, Bruce Ashford, Ardalan Ebrahami, Jonathan R Clark
BACKGROUND: Innervated free muscle transfer using the gracilis muscle or temporalis myoplasty has been successfully utilized for facial reanimation in chronic facial palsy. These techniques are less suited to immediate facial reconstruction in the setting of radical parotidectomy, in which the complexity of the defect, patient age, postoperative radiotherapy, and limited life expectancy pose particular challenges. METHODS: We present a novel description of the use of a chimeric anterolateral thigh (ALT) flap and innervated vastus lateralis to achieve midface static suspension and dynamic reanimation in the setting of radical parotidectomy...
January 9, 2017: Head & Neck
https://www.readbyqxmd.com/read/28067967/feasibility-of-using-the-retroauricular-approach-without-endoscopic-or-robotic-assistance-for-excision-of-benign-neck-masses
#9
Dongbin Ahn, Jin Ho Sohn, Gil Joon Lee, Ki Ha Hwang
BACKGROUND: The purpose of this study was to present our evaluation of the feasibility of using a retroauricular approach for excision of benign upper neck mass lesions without assistance of an endoscopic or robotic system. METHODS: We enrolled 23 patients with benign neck mass lesions of the parotid gland, submandibular gland, and the level II/III region who underwent surgery via a retroauricular approach. RESULTS: In 22 of 23 patients (95...
January 9, 2017: Head & Neck
https://www.readbyqxmd.com/read/28039958/human-papillomavirus-status-and-the-relative-biological-effectiveness-of-proton-radiotherapy-in-head-and-neck-cancer-cells
#10
Li Wang, Xiaochun Wang, Yuting Li, Shichao Han, Jinming Zhu, Xiaofang Wang, David P Molkentine, Pierre Blanchard, Yining Yang, Ruiping Zhang, Narayan Sahoo, Michael Gillin, Xiaorong Ronald Zhu, Xiaodong Zhang, Jeffrey N Myers, Steven J Frank
BACKGROUND: Human papillomavirus (HPV)-positive oropharyngeal carcinomas response better to X-ray therapy (XRT) than HPV-negative disease. Whether HPV status influences the sensitivity of head and neck cancer cells to proton therapy or the relative biological effectiveness (RBE) of protons versus XRT is unknown. METHODS: Clonogenic survival was used to calculate the RBE; immunocytochemical analysis and neutral comet assay were used to evaluate unrepaired DNA double-strand breaks...
December 30, 2016: Head & Neck
https://www.readbyqxmd.com/read/28032937/prognostic-value-of-pretreatment-peripheral-blood-markers-in-paranasal-sinus-cancer-neutrophil-to-lymphocyte-and-platelet-to-lymphocyte-ratio
#11
Mario Turri-Zanoni, Giovanni Salzano, Alessia Lambertoni, Marta Giovannardi, Apostolos Karligkiotis, Paolo Battaglia, Paolo Castelnuovo
BACKGROUND: Pretreatment hematological markers have emerged as prognostic factors for several cancers. The purpose of this study was to present our investigation of the value of neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) in predicting recurrence and mortality for patients with primary sinonasal cancers (SNCs). METHODS: We carried out a retrospective review of patients with SNC who had been treated using endoscopic approaches from 2002 to 2014 at a single institute...
December 29, 2016: Head & Neck
https://www.readbyqxmd.com/read/28032719/minichromosome-maintenance-protein-7-and-geminin-expression-prognostic-value-in-laryngeal-squamous-cell-carcinoma-in-patients-treated-with-radiotherapy-and-cetuximab
#12
Giovanni Almadori, Libero Lauriola, Antonella Coli, Francesco Bussu, Roberto Gallus, Domenico Scannone, Vincenzo Valentini, Gaetano Paludetti, Thomas E Carey, Franco O Ranelletti
BACKGROUND: Minichromosome maintenance protein 7 (MCM7) is a downstream of human epidermal growth receptor (HER1) signaling. We examined MCM7, geminin, and HER1 expression in patients with laryngeal squamous cell carcinoma (SCC) treated with radiotherapy and cetuximab. METHODS: MCM7, geminin, and HER1 were evaluated by immunohistochemistry on 61 patients with laryngeal SCC. The follow-up (median, 32.1 months; range, 2-139 months) went from the beginning of therapy to tumor progression-free survival (PFS) and death (overall survival [OS])...
December 29, 2016: Head & Neck
https://www.readbyqxmd.com/read/28032690/free-profunda-femoris-artery-perforator-flap-as-a-first-line-choice-of-reconstruction-for-partial-glossectomy-defects
#13
Ricardo Fernández-Riera, Shao-Yu Hung, Jerry Chih-Wei Wu, Chung-Kan Tsao
BACKGROUND: Free profunda artery perforator (PAP) flap has recently been brought back for head and neck reconstruction. During the course of 1 year, we performed this procedure for reconstruction of partial glossectomy defects with excellent results. METHODS: From January through December 2015, 21 patients underwent partial glossectomy reconstruction with PAP flaps. Demographics, surgical technique, anatomic variations, success rates, complications, and characteristics are described...
December 29, 2016: Head & Neck
https://www.readbyqxmd.com/read/28032687/transnasal-endoscopic-partial-maxillectomy-operative-nuances-and-proposal-for-a-comprehensive-classification-system-based-on-1378-cases
#14
Mario Turri-Zanoni, Paolo Battaglia, Apostolos Karligkiotis, Davide Lepera, Jacopo Zocchi, Iacopo Dallan, Maurizio Bignami, Paolo Castelnuovo
BACKGROUND: Despite the development of functional endoscopic endonasal surgery, there are still areas of the maxillary sinus that remain technically difficult to access using a standard middle meatal antrostomy as well as deep-seated skull base lesions requiring expanded transmaxillary approaches. METHODS: All patients who underwent transnasal endoscopic partial maxillectomy (TEPM) in a single institution from 2000 to 2014 were retrospectively reviewed. The TEPM was classified into 5 types according to the anatomic structures progressively removed and to the access provided...
December 29, 2016: Head & Neck
https://www.readbyqxmd.com/read/28032684/timing-of-neck-dissection-in-association-with-transoral-surgery-a-systematic-review
#15
REVIEW
Costa Repanos, Adal H Mirza, Michael George, Petros D Karkos
BACKGROUND: The purpose of this study was to present our evaluation of the importance of timing (early vs synchronous vs delayed) in conjunction with transoral laser surgery for head and neck squamous cell carcinoma (HNSCC). METHODS: Articles addressing surgical management via transoral laser surgery for HNSCC were included for review. RESULTS: Twenty-six articles fulfilled our criteria. The overall 5-year disease-specific survival (DSS) was 75...
December 29, 2016: Head & Neck
https://www.readbyqxmd.com/read/28032680/cardiovascular-risk-and-prevention-in-patients-with-head-and-neck-cancer-treated-with-radiotherapy
#16
Christian C Okoye, Jessica Bucher, Curtis Tatsuoka, Sahil A Parikh, Guilherme H Oliveira, Michael K Gibson, Mitchell Machtay, Min Yao, Chad A Zender, Jennifer A Dorth
BACKGROUND: The underlying contributors to cardiovascular disease (CVD) in patients with head and neck squamous cell carcinoma (HNSCC) are poorly characterized. METHODS: Patients with HNSCC who underwent definitive or adjuvant (chemo)radiation between 2011 and 2013 were retrospectively reviewed. The 10-year risk estimates for a CVD event were calculated according to the Framingham Risk Score (FRS). RESULTS: One hundred fifteen patients with predominantly stage III/IV HNSCC had a median follow-up of 2 years...
December 29, 2016: Head & Neck
https://www.readbyqxmd.com/read/28032679/acr-appropriateness-criteria-%C3%A2-nasal-cavity-and-paranasal-sinus-cancers
#17
Farzan Siddiqui, Richard V Smith, Sue S Yom, Jonathan J Beitler, Paul M Busse, Jay S Cooper, Ehab Y Hanna, Christopher U Jones, Shlomo A Koyfman, Harry Quon, John A Ridge, Nabil F Saba, Francis Worden, Min Yao, Joseph K Salama
The American College of Radiology (ACR) Appropriateness Criteria are evidence-based guidelines for specific clinical conditions that are reviewed annually by a multidisciplinary expert panel. The guideline development and revision include an extensive analysis of current medical literature from peer-reviewed journals and the application of well-established methodologies (RAND/UCLA Appropriateness Method and Grading of Recommendations Assessment, Development, and Evaluation or GRADE) to rate the appropriateness of imaging and treatment procedures for specific clinical scenarios...
December 29, 2016: Head & Neck
https://www.readbyqxmd.com/read/28032671/efficacy-and-safety-of-ultrasound-guided-radiofrequency-ablation-of-hyperplastic-parathyroid-gland-for-secondary-hyperparathyroidism-associated-with-chronic-kidney-disease
#18
Chengzhong Peng, Zhengxian Zhang, Jibin Liu, Hongyu Chen, Xiao Tu, Rihong Hu, Jun Ni, Ning Weng, Haisu Pang, Zhengmei Xue
BACKGROUND: The purpose of this study was to determine if ultrasound-guided radiofrequency ablation (RFA) of hyperplastic parathyroid glands could be used to treat secondary hyperparathyroidism (HPT) in patients with chronic kidney disease. METHODS: RFA of the hyperplastic parathyroid glands was performed in 34 patients with secondary HPT. Intact parathyroid hormone (iPTH), calcium, and phosphorus were measured. The outcome was based on the ablation extent (ie, 4, 3, and 1-2 glands)...
December 29, 2016: Head & Neck
https://www.readbyqxmd.com/read/28032670/prospective-study-of-definitive-chemoradiation-in-locally-or-regionally-advanced-squamous-cell-carcinoma-of-the-skin
#19
Michelle K Nottage, Charles Lin, Brett G M Hughes, Lizbeth Kenny, David D Smith, Kathleen Houston, Alessandra Francesconi
BACKGROUND: The purpose of this study was to present our evaluation of the outcomes of concurrent chemoradiotherapy (CRT) in patients with locally advanced cutaneous squamous cell carcinoma (SCC). METHODS: This was a prospective phase II study. The primary endpoint was complete response (CR). Patients with locally/regionally advanced cutaneous SCC deemed unsuitable for surgery received definitive radiotherapy (RT; 70 Gy in 35fractions) and concurrent weekly platinum-based chemotherapy (cisplatin 40 mg/m2 or carboplatin area under the curve 2)...
December 29, 2016: Head & Neck
https://www.readbyqxmd.com/read/28006088/case-of-parotid-mucoepidermoid-carcinoma-expanding-the-spectrum-of-von-hippel-lindau-related-neoplasms
#20
Michael H Berger, Darcy A Kerr, Artur E Rangel Filho, Zoukaa B Sargi
BACKGROUND: von Hippel-Lindau (VHL)-related tumors occurring outside the spectrum of VHL-defining tumors are rare, and mucoepidermoid carcinoma (MEC) in the setting of VHL disease has not been described. METHODS AND RESULTS: We describe a patient with confirmed VHL mutation who presented with a parotid mass and a history of 2 central nervous system (CNS) hemangioblastomas and 1 pheochromocytoma. Fine-needle aspiration (FNA) of the mass suggested a benign Warthin tumor...
December 22, 2016: Head & Neck
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