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Head & Neck

Yao Yu, Marc Mabray, William Silveira, Peter Y Shen, William R Ryan, Alina Uzelac, Sue S Yom
BACKGROUND: The purpose of this study was to test if diffusion-weighted imaging (DWI) identified persistent neck disease after chemoradiotherapy (CRT) for oropharyngeal cancer earlier and as accurately as subsequent positron emission tomography (PET)/CT. METHODS: We performed a review of patients with oropharyngeal cancer treated with definitive CRT who underwent DWI and PET/CT at a median of 8 and 14 weeks posttreatment. Imaging characteristics were correlated with pathologically proven neck failure...
October 11, 2016: Head & Neck
Jonah D Klein, Michael E Kupferman
BACKGROUND: Li-Fraumeni syndrome (LFS) is a familial cancer predisposition associated with a germline mutation in TP53. Patients with LFS are at risk of developing malignancies and require comprehensive screening. We describe an index case of LFS presenting with mucosal melanoma. METHODS: A 21-year-old woman presented with a left maxillary mucosal lesion and a left neck mass. Biopsies revealed metastatic mucosal melanoma, which is a pathology previously unreported in LFS families...
October 11, 2016: Head & Neck
Ji-Hoon Jung, Sang-Woo Lee, Seung Hyun Son, Choon-Young Kim, Chang-Hee Lee, Ju Hye Jeong, Shin Young Jeong, Byeong-Cheol Ahn, Jaetae Lee
BACKGROUND: The purpose of this retrospective study was to assess the diagnostic value of (18) F-fluorodeoxyglucose (FDG) positron emission tomography (PET)/CT and the prognostic value of metabolic PET parameters in patients with adenoid cystic carcinoma of the head and neck (ACCHN). METHODS: Forty patients with newly diagnosed ACCHN were enrolled in this study. We investigated the diagnostic value of (18) F-FDG PET/CT for detecting and staging compared to conventional CT...
October 11, 2016: Head & Neck
Lorenz Kadletz, Stefan Grasl, Matthäus C Grasl, Christos Perisanidis, Boban M Erovic
BACKGROUND: The purpose of this study was to evaluate the clinical outcome in patients with benign parotid gland tumors after extracapsular dissection or superficial parotidectomy (SP). METHODS: Eight hundred ninety-four patients with primary pleomorphic adenoma or Warthin's tumor were included from this study. Type and length of surgery, tumor size, resection margins, and complication rates were assessed. RESULTS: Three hundred ninety-five (44...
October 5, 2016: Head & Neck
Julia R Van Liew, Rebecca L Brock, Alan J Christensen, Lucy Hynds Karnell, Nitin A Pagedar, Gerry F Funk
BACKGROUND: Weight loss and depressive symptoms are critical head and neck cancer outcomes, yet their relation over the illness course is unclear. METHODS: Associations between self-reported depressive symptoms and objective weight loss across the year after head and neck cancer diagnosis were examined using growth curve modeling techniques (n = 564). RESULTS: A reciprocal covariation pattern emerged-changes in depressive symptoms over time were associated with same-month changes in weight loss (t [1148] = 2...
October 5, 2016: Head & Neck
Thomas Frisch
BACKGROUND: The facial artery myomucosal (FAMM) island flap is a cheek flap, pedicled on the facial artery and suitable for small to medium-sized reconstructions of the oral cavity and neighboring areas. A novel transposition of the flap to the hypopharynx after laryngectomy is presented in this report. METHODS: A 58-year-old man, previously irradiated, was laryngopharyngectomized because of a new supraglottic carcinoma. An unexpected need for a flap was solved by tunneling a FAMM island flap lateral to the mandible...
October 5, 2016: Head & Neck
Agnaldo J Graciano, Carlos A Fischer, Carlos T Chone, Giuliano S Bublitz, Marina Sonagli, Cezar A Rodrigues Filho
BACKGROUND: There are a growing number of thyroid ultrasound courses to train endocrinologists, pathologists, and surgeons to perform ultrasound-guided fine-needle aspiration (FNA). However, there are limited data to support the efficacy of ultrasound-guided FNA performed by nonradiologists. METHODS: We compared the efficacy of ultrasound-guided FNA performed by surgeons newly trained in thyroid ultrasound with that of the same technique performed by 1 experienced radiologist...
October 5, 2016: Head & Neck
Lachlan J McDowell, Marlene C Jacobson, Wilfred Levin
BACKGROUND: Hypoglossal nerve palsies are infrequent complications of head and neck radiotherapy. Treatments focus on maintaining function and prevention of abnormal airway-related swallowing events. METHODS: A patient with longstanding cranial neuropathies, including bilateral hypoglossal involvement, secondary to chemoradiotherapy for nasopharyngeal carcinoma, experienced repeated episodes of life-threatening complications. Initially, 2 courses of 2 weekly 24-hour intravenous methylprednisolone (IVMP) infusions were administered 2 years apart...
October 5, 2016: Head & Neck
Giovanni Succo, Erika Crosetti, Andy Bertolin, Marco Lucioni, Giuseppe Rizzotto
The first supratracheal partial laryngectomy (STPL) with tracheohyoidoepiglottopexy was performed in 1972. This procedure entailed preservation of the suprahyoid epiglottis as well as a pexy of the hyoid bone and residual epiglottis to the first tracheal ring; however, this technique was abandoned by the same author in the early 1980s because of poor functional outcomes. © 2016 Wiley Periodicals, Inc. Head Neck, 2016.
October 5, 2016: Head & Neck
Young Jun Choi, Jung Hwan Baek, Chong Hyun Suh, Woo Hyun Shim, Boseul Jeong, Jae Kyun Kim, Dong Eun Song, Tae Yong Kim, Ki-Wook Chung, Jeong Hyun Lee
BACKGROUND: The purpose of this study was to evaluate the role of core-needle biopsy (CNB) by comparing the results of CNB and repeat fine-needle aspiration (FNA) for thyroid nodules that are initially read as atypia/follicular lesion of undetermined significance (AUS/FLUS) on FNA. METHODS: Among 2631 initial AUS/FLUS FNA results, 505 consecutive nodules (295 repeat FNAs and 210 CNBs) were retrospectively analyzed. The primary outcome was inconclusive (ie, nondiagnostic or AUS/FLUS)...
October 5, 2016: Head & Neck
Ji Hye Lee, Hyun Joo Shin, Jung Hyun Yoon, Eun-Kyung Kim, Hee Jung Moon, Hye Sun Lee, Hyeong Ju Kwon, Jin Young Kwak
BACKGROUND: For patients with papillary thyroid carcinoma (PTC), lymph node metastasis is associated with an increased recurrence rate. The purpose of this study was to investigate whether the vascular endothelial growth factor (VEGF), microvessel density (MVD), and vascular index (VI) can predict lymph node metastasis in patients with PTC. METHODS: From January 2011 to October 2011, 202 patients with PTCs underwent preoperative staging ultrasound evaluation. To evaluate vascularity, we measured the VI, VEGF expression, and MVD...
October 5, 2016: Head & Neck
Zubeyde Yalniz, Semra Demokan, Burak Karabulut, Murat Ulusan, Yusufhan Suoglu, Nejat Dalay
BACKGROUND: Sensitive and reliable new biomarkers are needed in head and neck cancer to predict the outcome and for therapy that is more effective. Copy number alterations are frequent and play a critical role in cancer. METHODS: Copy number alterations of 24 tumor suppressor genes in head and neck cancer were analyzed simultaneously in matched tumor and normal samples from 93 patients using multiplex ligation-dependent probe amplification (MLPA). RESULTS: Chromosomes 3p and 9p displayed the most common alterations...
October 3, 2016: Head & Neck
Wen-Cheng Chen, Chia-Hsuan Lai, Huei-Chieh Chuang, Paul-Yang Lin, Miao-Fen Chen
BACKGROUND: The purpose of this study was to present our assessment of the significance of myeloid-derived suppressor cells (MDSCs) in head and neck squamous cell carcinoma (HNSCC). METHODS: We examined the percentage of MDSCs in the peripheral blood of patients with HNSCC. The relationship among MDSC recruitment, tumor progression, and cyclooxygenase (COX)-2 inhibition was also evaluated by animal models. RESULTS: Circulating MDSCs were significantly increased in patients with HNSCC compared with healthy people, and this was associated with the clinical tumor burden...
October 3, 2016: Head & Neck
Jia Hui Ng, N Gopalakrishna Iyer, Min-Han Tan, Gustaf Edgren
BACKGROUND: There are reports about the changing epidemiology of tongue squamous cell carcinoma (SCC), with recent reports indicating an increasing incidence in young women. METHODS: Data on incident cases of tongue SCC were collected from cancer registries worldwide. RESULTS: Data from a total of 22 cancer registries and 89,212 incident cases of tongue SCC worldwide were included. Most areas experienced an incidence increase ranging from 0...
October 3, 2016: Head & Neck
Joseph Scharpf, Michael Tuttle, Richard Wong, Drew Ridge, Russell Smith, Dana Hartl, Robert Levine, Gregory Randolph
This American Head and Neck Society (AHNS) consensus statement focuses on the detection and management of recurrent thyroid cancer. This document describes the radiologic approach to defining structural recurrent disease and the operative and nonoperative rationale in addressing identified structural disease to create equipoise in the personalized treatment strategy for the patient. The recommendations of this AHNS multidisciplinary consensus panel of the American Head and Neck Society are intended to help guide all multidisciplinary clinicians who diagnose or manage adult patients with thyroid cancer...
September 22, 2016: Head & Neck
Deming Wang, Lixin Su, Yifeng Han, Zhenfeng Wang, Lianzhou Zheng, Jichen Li, Xindong Fan
BACKGROUND: The purpose of this study was to evaluate the safety and efficacy of direct intralesional ethanol sclerotherapy for venous malformations (VMs) with oropharyngeal involvement after a temporary tracheotomy. METHODS: A retrospective assessment was carried out to evaluate the efficacy of direct intralesional ethanol sclerotherapy on 21 consecutive patients presenting with extensive VMs involving the oropharynx in the head and neck and who had undergone tracheotomy...
September 22, 2016: Head & Neck
Christine H Chung, Alexis Germain, Rathan M Subramaniam, Andreas M Heilmann, Kyle Fedorchak, Siraj M Ali, Vincent A Miller, Robert A Palermo, Carole Fakhry
BACKGROUND: Despite recent advances, survival outcomes for those with metastatic or recurrent head and neck squamous cell carcinoma (HNSCC) have remained poor. Novel approaches should be investigated to improve outcomes. METHODS: A retrospective chart review was performed of a patient who presented with a TNM classification III HNSCC of the oropharynx, positive for human papillomavirus (HPV) who had a complete response to a human epidermal growth factor receptor 2 (HER2)-targeted therapy...
September 21, 2016: Head & Neck
Vikas Mehta, José M Flores, Richard Will Thompson, Cherie-Ann Nathan
BACKGROUND: Medicaid and uninsured patients anecdotally incur higher cost and length of stay because of nonmedical, discharge-related factors. The purpose of this study was to investigate the association between primary payer and length of stay and cost, controlling for comorbidities and complications, in patients undergoing total laryngectomy. METHODS: The sample included 4128 patients who underwent total laryngectomy in the 2005 to 2010 National Inpatient Sample (NIS)...
September 21, 2016: Head & Neck
Rob Noorlag, Koos Boeve, Max J H Witjes, Ronald Koole, Ton L M Peeters, Ed Schuuring, Stefan M Willems, Robert J J van Es
BACKGROUND: Accurate nodal staging is pivotal for treatment planning in early (stage I-II) oral cancer. Unfortunately, current imaging modalities lack sensitivity to detect occult nodal metastases. Chromosomal region 11q13, including genes CCND1, Fas-associated death domain (FADD), and CTTN, is often amplified in oral cancer with nodal metastases. However, evidence in predicting occult nodal metastases is limited. METHODS: In 158 patients with early tongue and floor of mouth (FOM) squamous cell carcinomas, both CCND1 amplification and cyclin D1, FADD, and cortactin protein expression were correlated with occult nodal metastases...
September 21, 2016: Head & Neck
Haim Gavriel, Ephraim Eviatar, Rani Abu Eta
BACKGROUND: Although hyperbaric oxygen therapy (HBOT) is used to treat chronic radiation tissue injury, clinical evidence supporting its use in maxillary bone osteoradionecrosis (ORN) is lacking. Therefore, the purpose of this study was to report our results of collected patient outcomes from a single center's large experience using HBOT to treat maxillary bone ORN. METHODS: From 1999 to 2015, 21 patients received treatment for maxillary bone ORN at our center. The medical records were retrospectively reviewed for the following variables: age, sex, comorbidities, tumor stage and site, previous surgery, previous radiotherapy or chemoradiation therapy, HBOT data, response to treatment and further management...
September 19, 2016: Head & Neck
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