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Head & Neck

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https://www.readbyqxmd.com/read/28708300/radioprotective-effect-of-thymoquinone-on-salivary-gland-of-rats-exposed-to-total-cranial-irradiation
#1
Mehmet Akyuz, Seyithan Taysi, Elif Baysal, Elif Demir, Hilal Alkis, Muslum Akan, Habip Binici, Zeynel Abidin Karatas
BACKGROUND: The purpose of this study was to investigate the radioprotective effects of thymoquinone against radiation-induced damage in the salivary glands of rats exposed to total cranial gamma irradiation. METHODS: Thirty-two Sprague-Dawley rats were divided into 4 groups to test the radioprotective effectiveness of thymoquinone by intraperitoneal injection. An appropriate control group was also studied. Biochemical parameters in liver tissue of rats were determined by spectrophotometer...
July 14, 2017: Head & Neck
https://www.readbyqxmd.com/read/28708279/population-based-reference-values-for-the-european-organization-for-research-and-treatment-of-cancer-head-and-neck-module
#2
Eva Hammerlid, Ali Adnan, Ewa Silander
BACKGROUND: The purpose of this study was to establish population-based norms for the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-Head and Neck 35 (EORTC QLQ-HN35) to be used as references to facilitate the interpretation of results from health-related quality of life (HRQOL) studies of patients with head and neck cancer. METHODS: The European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-Core 30 (EORTC QLQ-C30) and QLQ-HN35 were sent to a random sample representing the Swedish general population...
July 14, 2017: Head & Neck
https://www.readbyqxmd.com/read/28695624/life-quality-improvement-in-hoarse-patients-with-early-glottic-cancer-after-transoral-laser-microsurgery
#3
Li-Jen Hsin, Wan-Ni Lin, Tuan-Jen Fang, Li-Ang Lee, Chung-Jan Kang, Bing-Shan Huang, Chien-Yu Lin, Kang-Hsing Fan, Ngan-Ming Tsang, Cheng-Lung Hsu, Joseph Tung-Chieh Chang, Chun-Ta Liao, Tzu-Chen Yen, Kai-Ping Chang, Hsiu-Feng Chuang, Hsueh-Yu Li
BACKGROUND: The purpose of this study was to evaluate the recovery kinetics of voice and quality of life (QOL) over time in patients with early glottic cancer who underwent transoral laser microsurgery (TLM). METHODS: A prospective cohort study was conducted in which acoustic and aerodynamic voice assessments and QOL analyses were done using health-related questionnaires (European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-Core 30-questions [EORTC-QLQ-C30] and European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-Head and Neck 35-questions [EORTC-QLQ-H&N35]) were administered at designated times...
July 11, 2017: Head & Neck
https://www.readbyqxmd.com/read/28691358/survival-benefit-of-surgical-approach-for-advanced-oropharyngeal-and-hypopharyngeal-cancer-a-retrospective-analysis
#4
Chih-Tao Cheng, Ching-Yuan Lin, Skye Hung-Chun Cheng, Yi-Ping Lin, Lay-Chin Lim, Nicolas Pennarun, Zhen-Ying Liu, Shyuang-Der Terng
BACKGROUND: Head and neck cancer is increasingly being managed through nonsurgical approaches. Evidence comes from studies that have mainly examined patients with laryngeal cancer. Few studies, with limited sample size, have focused on the comparative outcomes of surgical and nonsurgical approaches in patients with advanced oropharyngeal or hypopharyngeal cancer. METHODS: Using a national cancer database, we identified 1603 and 1512 patients with clinical stage III/IVA oropharyngeal and hypopharyngeal cancer, respectively, treated between 2004 and 2009...
July 10, 2017: Head & Neck
https://www.readbyqxmd.com/read/28691354/feasibility-of-a-wait-and-scan-period-as-initial-management-strategy-for-head-and-neck-paraganglioma
#5
Thijs T G Jansen, Henri J L M Timmers, Henri A M Marres, Henricus P M Kunst
BACKGROUND: The main goal of head and neck paraganglioma (PGL) management is reduction of treatment-induced and tumor-induced complications. In the current study, tumor growth rates and tumor-induced complications during a wait-and-scan period are evaluated. METHODS: This was a retrospective cohort study. Tumor growth was measured in axial plane diameter and tumor volume. RESULTS: Of 59 jugulotympanic tumors, 71 carotid body tumors, and 29 vagal body tumors, 44% were growing (median follow-up of 63...
July 10, 2017: Head & Neck
https://www.readbyqxmd.com/read/28691255/impact-of-human-papillomavirus-on-outcome-in-patients-with-oropharyngeal-cancer-treated-with-primary-surgery
#6
Martina A Broglie, Sandro J Stoeckli, Rafael Sauter, Philippe Pasche, Antoine Reinhard, Laurence de Leval, Gerhard F Huber, Thomas F Pezier, Alex Soltermann, Roland Giger, Andreas Arnold, Matthias Dettmer, Andre Arnoux, Martin Müller, Stefan Spreitzer, Florian Lang, Mathieu Lutchmaya, Edouard Stauffer, Vittoria Espeli, Francesco Martucci, Massimo Bongiovanni, Diana Foerbs, Wolfram Jochum
BACKGROUND: Knowledge about prognostic factors in surgically treated patients with oropharyngeal squamous cell carcinoma (SCC) is limited. The purpose of this study was to identify influential factors on survival in a large cohort of patients with surgically treated oropharyngeal SCC. METHODS: Retrospective analysis of survival estimates in patients with surgically treated oropharyngeal SCC using tumoral positivity for human papillomavirus (HPV) and risk-of-death categories according to a study from 2010 as stratification factors...
July 10, 2017: Head & Neck
https://www.readbyqxmd.com/read/28688124/impact-of-the-pretreatment-glasgow-prognostic-score-on-treatment-tolerance-toxicities-and-survival-in-patients-with-advanced-head-and-neck-cancer-undergoing-concurrent-chemoradiotherapy
#7
Pei-Hung Chang, Kun-Yun Yeh, Cheng-Hsu Wang, Eric Yen-Chao Chen, Shih-Wei Yang, Jen-Seng Huang, Wen-Chi Chou, Jason Chia-Hsun Hsieh
BACKGROUND: The purpose of this study was to evaluate the impact of the pretreatment Glasgow prognostic score on treatment-related toxicities, tolerance, and survival in patients with advanced head and neck cancers undergoing concurrent chemoradiotherapy (CRT). METHODS: We retrospectively analyzed and compared the clinical characteristics, toxicities, and survival of 143 patients with stages III, IVA, and IVB head and neck cancer treated with concurrent CRT according to their Glasgow prognostic score between 2007 and 2010...
July 7, 2017: Head & Neck
https://www.readbyqxmd.com/read/28681422/prognostic-indicators-and-survival-in-salvage-surgery-for-laryngeal-cancer
#8
Kyle T Fletcher, Thomas J Gal, Andrew J Ebelhar, Joseph Valentino, Yolanda M Brill, Emily V Dressler, Rony K Aouad
BACKGROUND: Perineural invasion (PNI) and lymphovascular invasion (LVI) are known to be poor prognostic indicators in primary surgery. The purpose of this study was to determine their impact on survival in the setting of salvage laryngectomy. METHODS: We conducted a retrospective review of patients who underwent salvage laryngectomy between 2006 and 2014. RESULTS: Seventy-eight patients were included in this study; PNI was diagnosed in 48 patients (61...
July 6, 2017: Head & Neck
https://www.readbyqxmd.com/read/28675642/phosphorylated-ribosomal-protein-s6-correlation-with-p21-expression-and-inverse-association-with-tumor-size-in-oral-squamous-cell-carcinoma
#9
Juan C de Vicente, Ignacio Peña, Juan P Rodrigo, Tania Rodríguez-Santamarta, Paloma Lequerica-Fernández, Laura Suárez-Fernández, Eva Allonca, Juana M García-Pedrero
BACKGROUND: The purpose of this study was to investigate the clinical relevance of phosphorylated ribosomal protein S6 (p-S6), a surrogate marker of mammalian target of rapamycin (mTOR) activation, and p21 in a series of 125 patients with oral squamous cell carcinomas (OSCCs). METHODS: Immunohistochemical analysis was performed to ascertain the phosphorylation status of p-S6 at Ser235/236 and Ser240/244, p21, and p53 protein expression. RESULTS: Expression of phosphorylated S6 protein on either serine 235/236 or serine 240/244 was detected in 83% and 88% tumors, respectively, and both of them were inversely and significantly correlated with the tumor size and local infiltration...
July 4, 2017: Head & Neck
https://www.readbyqxmd.com/read/28675554/osteocutaneous-radial-forearm-free-flap-in-nonmandible-head-and-neck-reconstruction
#10
Faisal I Ahmad, Casey Means, Alex B Labby, Scott H Troob, Javier D Gonzalez, Michael M Kim, Ryan J Li, Mark K Wax
BACKGROUND: The osteocutaneous radial forearm free flap (RFFF) is a versatile flap primarily used to reconstruct composite defects involving the mandible. The purpose of this study was to describe our experience with this flap for nonmandible reconstruction. METHODS: All patients undergoing nonmandible osseous reconstruction with free-tissue transfer were reviewed. Patients with osteocutaneous RFFF reconstructions were evaluated. The retrospective review of all osteocutaneous RFFFs was performed from 1998 to 2014...
July 4, 2017: Head & Neck
https://www.readbyqxmd.com/read/28675547/baroreceptor-reflex-failure-review-of-the-literature-and-the-potential-impact-on-patients-with-head-and-neck-cancer
#11
Shivani Shah-Becker, Michael Pennock, Lawrence Sinoway, David Goldenberg, Neerav Goyal
BACKGROUND: Baroreceptor dysfunction and reflex failure may occur after surgery affecting the carotid artery. The implications for patients undergoing treatment for head and neck cancer are not well described. METHODS: A literature search of PubMed was performed between March 2016 and May 2016. Search terms used individually and in combination included: "baroreflex failure," "carotid sinus sensitivity," "carotid endarterectomy," "carotid body tumor," and "head and neck cancer...
July 4, 2017: Head & Neck
https://www.readbyqxmd.com/read/28675541/novel-approach-to-maxillary-reconstruction-using-osteocutaneous-free-tissue-transfer-with-a-customized-stent
#12
Vivek R Varma, Yin Yiu, Meade Van Putten, Tiffany L Kessling, Enver Ozer, Amit Agrawal, Theodoros Teknos, Stephen Y Kang, Matthew O Old
BACKGROUND: Computer-guided 3D virtual planning and customized templates are novel and effective methods aiding maxillary reconstruction, particularly during osteocutaneous free tissue transfer of complex defects. However, virtual planning and modelling is often expensive. METHODS: We present a new method to reconstruct complex defects with a surgical stent designed from presurgical casts. We present 2 patients who underwent this technique. Reconstruction in both cases was aided by a surgical stent fashioned preoperatively to approximate the anatomic dimensions of the defect, guiding the shape and orientation of the flap during inset to aid in dental rehabilitation...
July 4, 2017: Head & Neck
https://www.readbyqxmd.com/read/28661559/use-of-a-midline-mandibular-osteotomy-to-improve-surgical-access-for-transoral-robotic-resection-of-the-base-of-tongue-in-a-patient-with-trismus
#13
Gerald Tay, Jay Ferrell, Peter Andersen
BACKGROUND: The utilization of transoral robotic surgery (TORS) in patients with trismus is limited because of poor surgical exposure. METHODS: This report is about a 46-year-old man with a recurrent right base of tongue cancer who had severe postradiation trismus. We performed a midline mandibular osteotomy without a lip split and this resulted in a markedly improved surgical exposure. He underwent a TORS resection of the right base of the tongue with no significant complications...
June 29, 2017: Head & Neck
https://www.readbyqxmd.com/read/28661556/synopsis-of-transoral-endoscopic-laryngopharyngeal-surgery-for-superficial-pharyngeal-cancers
#14
Akihito Watanabe, Masanobu Taniguchi, Yuki Kimura, Masao Hosokawa, Suguru Ito, Shinji Tsukamoto, Shigeyuki Sasaki
BACKGROUND: Endoscopic laryngopharyngeal surgery (ELPS) was developed for superficial pharyngeal cancers in Japan. In this study, we present our results of ELPS for superficial pharyngeal cancers. METHODS: From November 2009 to December 2015, 258 patients with superficial pharyngeal cancers underwent ELPS. Results, including survival rates, postoperative complications, and vocal function, are reviewed. RESULTS: The median follow-up period of 258 patients was 31 months...
June 29, 2017: Head & Neck
https://www.readbyqxmd.com/read/28653453/ahns-series-do-you-know-your-guidelines-principles-of-treatment-for-glottic-cancer-a-review-of-the-national-comprehensive-cancer-network-guidelines
#15
Jessica Yesensky, Nishant Agrawal, Semirra Bayan, Elizabeth Blair, Louis Portugal, Jason Chan, David Goldenberg, Zhen Gooi
This article is a continuation of the "Do You Know Your Guidelines" series, an initiative of the American Head and Neck Society's Education Committee to increase awareness of current best practices pertaining to head and neck cancer. The National Comprehensive Cancer Network (NCCN) guidelines for primary and adjuvant treatment of cancer of the glottic larynx are reviewed here in a systematic fashion according to stage.
June 27, 2017: Head & Neck
https://www.readbyqxmd.com/read/28650113/distant-metastases-in-head-and-neck-cancer
#16
Fréderic Duprez, Dieter Berwouts, Wilfried De Neve, Katrien Bonte, Tom Boterberg, Philippe Deron, Wouter Huvenne, Sylvie Rottey, Marc Mareel
BACKGROUND: Most trials in head and neck cancer emphasize locoregional control, as this is the main pattern of therapy failure. However, up to 15% of patients develop distant metastases. The purpose of this study was to present the investigated factors associated with distant metastasis in a single-center patient cohort. METHODS: A retrospective analysis of a single-center patient cohort over an 18-year period has been performed. We report on prevalence and incidence of distant metastasis, timing in relation to locoregional failure, Kaplan-Meier analysis for actuarial distant control rates, and univariate analysis taking into account histological, etiologic, surgical, site-dependent, stage-dependent characteristics, modality of primary therapy, and locoregional control...
June 26, 2017: Head & Neck
https://www.readbyqxmd.com/read/28644558/current-understanding-of-cancer-stem-cells-review-of-their-radiobiology-and-role-in-head-and-neck-cancers
#17
REVIEW
Paul Ambrose Reid, Puthenparampil Wilson, Yanrui Li, Loredana Gabriela Marcu, Eva Bezak
Evidence of cancer cells that bear attributes analogous to those of normal stem cells has developed a hierarchical model of cancer's architecture and progression. This subset of cancer stem cells (CSCs) drives the progression and therapy resistance of cancers. Research to identify the phenotypes of these CSCs presents evidence of a subpopulation that is more resistant to therapy and may proliferate in response. Literature shows that CSCs typically represent around 1%-10% of cell populations in head and neck cancer but this proportion may increase in response to a therapeutic radiation dose...
June 23, 2017: Head & Neck
https://www.readbyqxmd.com/read/28644552/assessment-of-videofluoroscopic-swallow-study-findings-before-and-after-cricopharyngeal-myotomy
#18
Jacqui Allen, Dora Blair, Anna Miles
BACKGROUND: Cricopharyngeal myotomy is a treatment for obstructive cricopharyngeal bar and Zenker's diverticulitis. Little is reported regarding contrast study findings and their correlation with patient symptoms. METHODS: All patients treated by cricopharyngeal myotomy underwent a preoperative and postoperative videofluoroscopic swallow study (VFSS) and completed the self-reported Eating Assessment Tool (EAT-10). Studies were analyzed quantitatively. RESULTS: Forty cricopharyngeal myotomies were performed (mean age 76 years; SD 8...
June 23, 2017: Head & Neck
https://www.readbyqxmd.com/read/28644540/cytokeratin-19-expression-in-early-oral-squamous-cell-carcinoma-and-their-metastasis-inadequate-biomarker-for-one-step-nucleic-acid-amplification-implementation-in-sentinel-lymph-node-biopsy-procedure
#19
Rob Noorlag, Robert J J van Es, Remco de Bree, Stefan M Willems
BACKGROUND: Intraoperative analysis of lymph nodes during a sentinel lymph node biopsy (SLNB) procedure could result in one-step surgery for early oral squamous cell carcinoma (OSCC) with an occult nodal metastasis. One-step nucleic acid amplification rapidly detects cytokeratin 19 (CK19) RNA with high accuracy. Sensitivity and specificity of CK19 expression in OSCC was evaluated. METHODS: Immunohistochemical CK19 expression was done in 207 patients with OSCC with 65 cases of paired nodal metastases...
June 23, 2017: Head & Neck
https://www.readbyqxmd.com/read/28640533/high-risk-squamous-cell-carcinoma-of-the-ear-a-potential-role-for-sentinel-node-biopsy
#20
Suzanne Beecher, Paula F Wrafter, Cormac W Joyce, Padraic J Regan, Jack L Kelly
BACKGROUND: Squamous cell carcinomas (SCCs) of the external ear have a significant rate of metastasis. The purpose of this study was to present analyzed factors associated with auricular SCC metastasis in order to identify a group that may benefit from sentinel lymph node biopsy (SLNB). METHODS: We performed a retrospective review of all operable SCCs between 2009 and 2014. The association between high-risk features and metastasis were analyzed. RESULTS: One hundred eighty-nine auricular SCCs were excised...
June 22, 2017: Head & Neck
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