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Head & Neck

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https://www.readbyqxmd.com/read/29761594/extracellular-interleukin-17f-has-a-protective-effect-in-oral-tongue-squamous-cell-carcinoma
#1
Rabeia Almahmoudi, Abdelhakim Salem, Meri Sieviläinen, Elias Sundquist, Alhadi Almangush, Sanna Toppila-Salmi, Timo Paavonen, Tuula Salo, Ahmed Al-Samadi
BACKGROUND: Oral tongue squamous cell carcinoma (SCC) is characterized by early metastasis and poor prognosis. Interleukin-17F (IL-17F) plays a protective role in many tumors. However, IL-17F expression in oral tongue SCC tissue has not been investigated. METHODS: Immunostaining of 83 oral tongue SCC specimens and blinded-scoring were used to map IL-17F expression, location, and distribution. Survival curves were constructed according to Kaplan-Meier method. The Cox proportional hazard model was applied for univariate and multivariate survival analyses...
May 14, 2018: Head & Neck
https://www.readbyqxmd.com/read/29761587/neutrophil-to-lymphocyte-ratio-as-a-prognostic-indicator-in-head-and-neck-cancer-a-systematic-review-and-meta-analysis
#2
REVIEW
Tristan Tham, Yonatan Bardash, Saori Wendy Herman, Peter David Costantino
BACKGROUND: The purposes of this systematic review and meta-analysis were to investigate the relationship between the neutrophil-to-lymphocyte ratio (NLR) and prognosis in head and neck cancer. METHODS: A systematic review and meta-analysis were done to investigate the role of NLR in overall survival (OS), disease-specific survival (DSS), disease-free survival (DFS), and progression-free survival (PFS). RESULTS: For qualitative analysis, 33 cohorts with over 10 072 patients were included...
May 14, 2018: Head & Neck
https://www.readbyqxmd.com/read/29761586/preoperative-predictors-of-occult-nodal-disease-in-ct1n0-oral-cavity-squamous-cell-carcinoma-review-of-2623-cases
#3
Kevin Y Zhan, Patrick F Morgan, David M Neskey, Joanne J Kim, Andrew T Huang, Elizabeth Garrett-Mayer, Terry A Day
BACKGROUND: Nodal disease predicts survival in oral cavity squamous cell carcinoma (SCC). Currently, no large studies on predictors of occult nodal disease in cT1N0 oral cavity SCC exist. METHODS: The National Cancer Database (NCDB) review for cT1N0 oral cavity SCC with surgical resection and elective neck dissection (END). RESULTS: The number of patients found with occult nodal disease was 2623 (15.1%). In multivariable regression, female sex and tumor differentiation predict occult nodal disease...
May 14, 2018: Head & Neck
https://www.readbyqxmd.com/read/29756412/adjuvant-therapy-in-major-salivary-gland-cancers-analysis-of-8580-patients-in-the-national-cancer-database
#4
Shayan Cheraghlou, Phoebe Kuo, Saral Mehra, George O Agogo, Aarti Bhatia, Zain A Husain, Wendell G Yarbrough, Barbara A Burtness, Benjamin L Judson
BACKGROUND: Evidence surrounding the effect of adjuvant treatment in salivary gland cancers is limited. The benefit of adding chemotherapy to adjuvant treatment is also of interest. We investigated the association of these treatments with survival and whether this differed by stage or the presence of adverse features. METHODS: A retrospective study of adult salivary gland cancer cases diagnosed from 2004 to 2013 in the National Cancer Data Base (NCDB) was conducted...
May 13, 2018: Head & Neck
https://www.readbyqxmd.com/read/29756404/nasal-fibroscopy-as-a-routine-screening-procedure-of-sinonasal-adenocarcinoma-of-woodworkers-french-longitudinal-case-study
#5
Julie Martin, Flora Vayr, Christophe Paris, Sébastien Vergez, Peggy Krief, Amandine Luc, Julie Corvisier, Ludovic de Gabory, Fabrice Herin
BACKGROUND: The purpose of this study was to assess the relevancy of flexible nasoendoscopy as a routine screening procedure of sinonasal adenocarcinoma among people occupationally exposed to wood dust. METHODS: This study included woodworkers, occupationally exposed to wood dust. Evaluations were scheduled at the time of inclusion (T0) and after a 2-year period (T1). A questionnaire was used for standardized data collection. The score was based on anatomic landmarks on each side that are parts of the olfactory clefts: the area of middle turbinate, the anterior part of the olfactory cleft, the top of the choanal arch, the spheno-ethmoidal recess, the posterior part of the olfactory cleft, and the middle part of the olfactory cleft...
May 13, 2018: Head & Neck
https://www.readbyqxmd.com/read/29756398/survival-without-adjuvant-chemotherapy-for-selected-patients-with-stage-ii-and-iii-nasopharyngeal-carcinoma-after-concurrent-chemoradiotherapy-alone
#6
Jia-Shing Wu, Yu-Chen Tsai, James Jer-Min Jian, Hsin-Hsuan Chen, Cheng-Fang Horng, Skye Hung-Chun Cheng
BACKGROUND: The role of adjuvant chemotherapy after concurrent chemoradiotherapy (CRT) for nasopharyngeal carcinoma (NPC) is controversial. We report our phase II prospective study of withholding adjuvant chemotherapy in a subgroup of patients with American Joint Committee on Cancer (AJCC) stage II and III NPC with low risk for metastasis. METHODS: Between April 1998 and December 2008, 263 patients with stage II (AJCC 1997 T2aN0, T1-T2aN1; AJCC 2010 T1N1) NPC or stage III (AJCC 1997 T1-T2aN2; AJCC 2010 T1N2) NPC were enrolled...
May 13, 2018: Head & Neck
https://www.readbyqxmd.com/read/29756397/topical-superoxide-dismutase-in-posttreatment-fibrosis-in-patients-with-head-and-neck-cancer
#7
Kelly C Landeen, William C Spanos, Laurie Gromer
BACKGROUND: Topical superoxide dismutase (SOD) has been shown to decrease postradiation fibrosis in some cancers but has not demonstrated an effect in patients with head and neck cancer. The purpose of this study was to determine if topical SOD is an effective treatment for postradiation neck fibrosis. METHODS: This was a randomized prospective blinded clinical study of topical SOD versus placebo for the treatment of neck fibrosis. Measures of fibrosis grade and quality of life were obtained at baseline and after 3 months of treatment...
May 13, 2018: Head & Neck
https://www.readbyqxmd.com/read/29756392/successful-treatment-of-severe-facial-lymphedema-by-lymphovenous-anastomosis
#8
Yusuke Inatomi, Sei Yoshida, Kenichi Kamizono, Masuo Hanada, Ryuji Yasumatsu, Hideki Kadota
BACKGROUND: Facial edema is a common complication after neck dissection and/or chemoradiotherapy for head and neck cancer. Edema subsides spontaneously in most cases but sometimes persists, in which case surgical intervention is required. We report a case of severe facial edema that showed significant improvement upon lymphovenous anastomosis (LVA). METHODS: A 66-year-old man with oral floor cancer developed progressive facial lymphedema after tumor resection, bilateral neck dissections, chemoradiotherapy, and fibular and rectus abdominis musculocutaneous flap transfer...
May 13, 2018: Head & Neck
https://www.readbyqxmd.com/read/29756389/pretreatment-risk-stratification-of-feeding-tube-use-in-patients-treated-with-intensity-modulated-radiotherapy-for-head-and-neck-cancer
#9
Nigel J Anderson, James E Jackson, Jennifer G Smith, Morikatsu Wada, Michal Schneider, Michael Poulsen, Maureen Rolfo, Maziar Fahandej, Hui Gan, Daryl Lim Joon, Vincent Khoo
BACKGROUND: The purpose of this study was to establish a risk stratification model for feeding tube use in patients who undergo intensity-modulated radiotherapy (IMRT) for head and neck cancers. METHODS: One hundred thirty-nine patients treated with definitive IMRT (+/- concurrent chemotherapy) for head and neck mucosal cancers were included in this study. Patients were recommended a prophylactic feeding tube and followed up by a dietician for at least 8 weeks postradiotherapy (post-RT)...
May 13, 2018: Head & Neck
https://www.readbyqxmd.com/read/29756367/oral-cancer-involving-masticator-space-t4b-review-of-literature-and-future-directions
#10
REVIEW
Nirav P Trivedi
The oral cancer with masticator-space involvement is classified as T4b disease. The limited data suggest that the masticator space is a complex anatomic area and tumors with varying degrees of infiltration may have different oncologic outcomes. It is not advisable to group all T4b tumors as one and consider them for palliative-intent treatment. A group of patients with limited spread (infra-notch) has potential for good outcome. These cancers can be considered for downstaging to T4a classification based on best available data and clinical considerations...
May 13, 2018: Head & Neck
https://www.readbyqxmd.com/read/29756364/free-jejunal-flap-transfer-with-multiple-vascular-pedicles-for-safe-and-reliable-pharyngoesophageal-reconstruction
#11
Tomoyuki Kurita, Tateki Kubo, Hiroki Tashima, Takashi Fujii
BACKGROUND: In pharyngoesophageal reconstruction, we transferred a long jejunum flap containing multiple pedicles to achieve a 100% flap survival rate, and used the redundant mesentery to cover important tissues and fill in the dead space to reduce common postoperative complications, such as surgical site infections and fistula formation. METHODS: A total of 243 jejunal flap transfers with multiple vascular anastomoses were reviewed to examine flap survival and rates of early postoperative complications, such as surgical site infections and fistula formation, perioperative mortality, and donor site morbidity...
May 13, 2018: Head & Neck
https://www.readbyqxmd.com/read/29756363/treatment-for-t3-to-t4a-laryngeal-cancer-by-open-partial-horizontal-laryngectomies-prognostic-impact-of-different-pathologic-tumor-subcategories
#12
Giovanni Succo, Erika Crosetti, Andy Bertolin, Cesare Piazza, Gabriele Molteni, Stefano Cirillo, Massimo Petracchini, Martina Tascone, Andrea Elio Sprio, Giovanni Nicolao Berta, Giorgio Peretti, Livio Presutti, Giuseppe Rizzotto
BACKGROUND: The purpose of this retrospective study was to identify subcategories in cT3 to cT4a supraglottic/glottic cancers, describing their different spreading patterns, and local and locoregional recurrence modes. METHODS: Four hundred eighty-nine patients who underwent open partial horizontal laryngectomies (OPHLs) were retrospectively classified as: subcategory I (anterior pT3 with normal arytenoid mobility); subcategory II (posterior pT3 with impaired/absent mobility); subcategory III (anterior pT4 with normal mobility); and subcategory IV (posterior pT4 with impaired/absent mobility)...
May 13, 2018: Head & Neck
https://www.readbyqxmd.com/read/29756338/marsupialization-of-mandibular-cystic-ameloblastoma-retrospective-study-of-7-years
#13
Zinan Yang, Qian Liang, Le Yang, Guang-Sen Zheng, Si-En Zhang, Xiao-Mei Lao, Yu-Jie Liang, Gui-Qing Liao
BACKGROUND: This retrospective study investigated the reduction rate and speed of shrinkage after marsupialization in mandibular cystic ameloblastoma and clarified whether marsupialization is appropriate for unicystic ameloblastoma and multicystic ameloblastoma. METHODS: Sixty-three patients with mandibular cystic ameloblastoma were initially treated with marsupialization. Premarsupialization and postmarsupialization panoramic radiographs were reviewed for reduction rate and speed of shrinkage, and then were evaluated with age, sex, tumor location, and tumor type...
May 13, 2018: Head & Neck
https://www.readbyqxmd.com/read/29756334/effect-of-cell-phone-radiofrequency-on-angiogenesis-and-cell-invasion-in-human-head-and-neck-cancer-cells
#14
Yaman M Alahmad, Mohammed Aljaber, Alaaeldin I Saleh, Huseyin C Yalcin, Tahar Aboulkassim, Amber Yasmeen, Gerald Batist, Ala-Eddin Al Moustafa
BACKGROUND: Today, the cell phone is the most widespread technology globally. However, the outcome of cell-phone radiofrequency on head and neck cancer progression has not yet been explored. METHODS: The chorioallantoic membrane (CAM) and human head and neck cancer cell lines, FaDu and SCC25, were used to explore the outcome of cell-phone radiofrequency on angiogenesis, cell invasion, and colony formation of head and neck cancer cells, respectively. Western blot analysis was used to investigate the impact of the cell phone on the regulation of E-cadherin and Erk1/Erk2 genes...
May 13, 2018: Head & Neck
https://www.readbyqxmd.com/read/29756327/use-of-radioiodine-131-scan-to-measure-influence-of-surgical-discipline-practice-and-volume-on-residual-thyroid-tissue-after-total-thyroidectomy-for-differentiated-thyroid-carcinoma
#15
Jin Soo A Song, Nico Moolman, Steven Burrell, Murali Rajaraman, Martin Joseph Bullock, Jonathan Trites, S Mark Taylor, Matthew H Rigby, Robert D Hart
BACKGROUND: Our study's purpose is to determine the influence of surgical discipline, surgeon site, and volume on remnant thyroid tissue visualized on radioactive iodine-131 (I-131) scans after total thyroidectomy and I-131 ablation in patients with well-differentiated thyroid carcinomas. METHODS: We retrospectively reviewed all cases of patients who received I-131 therapeutic ablation and postablation radioactive I-131 scans at our center after thyroidectomy to calculate the fraction of administered dose multiplied by 1000 (UDR1000)...
May 13, 2018: Head & Neck
https://www.readbyqxmd.com/read/29756307/age-adjusted-comorbidity-and-survival-in-locally-advanced-laryngeal-cancer
#16
Collin F Mulcahy, Abdallah S R Mohamed, Aasheesh Kanwar, Katherine A Hutcheson, Alokananda Ghosh, David Vock, Randal S Weber, Stephen Y Lai, Gary Brandon Gunn, Mark Zafereo, William H Morrison, Renata Ferrarotto, Adam S Garden, David I Rosenthal, Clifton D Fuller
BACKGROUND: The purpose of this study was to quantify the relationship among age, pretreatment comorbidity, and survival outcomes in patients with locally advanced laryngeal cancer. METHODS: Baseline comorbidity data were collected and age-adjusted Charlson Comorbidity Index (CCI) was calculated for each case. Kaplan-Meier and Cox proportional hazards modeling were used to determine associations with survival. RESULTS: For 548 patients, with a median age of 59 years (range 31-91 years), 58% were treated with larynx preservation and the rest with total laryngectomy and adjuvant radiotherapy (RT)...
May 13, 2018: Head & Neck
https://www.readbyqxmd.com/read/29756301/oligometastatic-status-as-predictor-of-survival-in-metastatic-human-papillomavirus-positive-oropharyngeal-carcinoma
#17
William G Albergotti, Shira Abberbock, Fasil Mathews, Robert L Ferris, Jonas T Johnson, Umamaheswar Duvvuri, Seungwon Kim
BACKGROUND: Oligometastasis is a good prognostic indicator when compared to widely metastatic disease in malignancies of other organ systems. We hypothesized that oligometastasis in human papillomavirus (HPV)-positive oropharyngeal squamous cell carcinoma (SCC) would be associated with better overall survival. METHODS: This is a retrospective review of all HPV-positive oropharyngeal SCC treated at one center with at least 1-year of follow-up. Patients were stratified into 2 cohorts: oligometastasis (1-2 metastases, confined to 1 organ system) or polymetastasis (>2 metastases or multiple organ involvement) with cohorts compared for time to distant metastasis and overall survival after metastasis...
May 13, 2018: Head & Neck
https://www.readbyqxmd.com/read/29756292/primary-intestinal-type-adenocarcinoma-of-the-oral-tongue-case-report-and-review-of-histologic-origin-and-oncologic-management
#18
Jenna Berg, Rodolfo E Manosalva, Andrew Coughlin, Yungpo Bernard Su, Tien-Shew Huang, John Gentry
BACKGROUND: Primary intestinal-type adenocarcinoma (ITAC) of the oral tongue is an extremely uncommon malignancy with only 3 cases reported in the literature. This high-grade malignancy originates from metaplasia of minor salivary glands. METHODS: A 40-year-old man presented with a gradually enlarging midline oral tongue mass, odynophagia, and dysphagia. Management included a median lingual glossectomy, bilateral neck dissections, and adjuvant chemoradiation with 5-fluorouracil (5-FU)...
May 13, 2018: Head & Neck
https://www.readbyqxmd.com/read/29756287/racial-differences-in-the-prevalence-of-oncogenic-oral-human-papillomavirus-infection-types-in-the-united-states-adult-population
#19
Samantha Raymond, Bian Liu, Emanuela Taioli
BACKGROUND: The purpose of this study was to describe the prevalence of oral human papillomavirus (HPV) types according to race and to examine risk factors for oral HPV infection in United States adults. METHODS: Using 2009-2014 data from the National Health and Nutrition Examination Survey, 13 981 subjects were examined. Prevalence of oral HPV and individual oncogenic HPV types were described according to race. Multivariable logistic and linear regressions were used to examine the risk factors for infection and coinfection...
May 13, 2018: Head & Neck
https://www.readbyqxmd.com/read/29756265/web-based-thyroid-imaging-reporting-and-data-system-malignancy-risk-of-atypia-of-undetermined-significance-or-follicular-lesion-of-undetermined-significance-thyroid-nodules-calculated-by-a-combination-of-ultrasonography-features-and-biopsy-results
#20
Young Jun Choi, Jung Hwan Baek, Jung Hee Shin, Woo Hyun Shim, Seon-Ok Kim, Won-Hong Lee, Dong Eun Song, Tae Yong Kim, Ki-Wook Chung, Jeong Hyun Lee
BACKGROUND: The purpose of this study was to construct a web-based predictive model using ultrasound characteristics and subcategorized biopsy results for thyroid nodules of atypia of undetermined significance/follicular lesion of undetermined significance (AUS/FLUS) to stratify the risk of malignancy. METHODS: Data included 672 thyroid nodules from 656 patients from a historical cohort. We analyzed ultrasound images of thyroid nodules and biopsy results according to nuclear atypia and architectural atypia...
May 13, 2018: Head & Neck
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