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Head & Neck

Gino Marioni, Rocco Cappellesso, Giancarlo Ottaviano, Elena Fasanaro, Rosario Marchese-Ragona, Niccolò Favaretto, Luciano Giacomelli, Vincenza Guzzardo, Alessandro Martini, Ambrogio Fassina, Stella Blandamura
BACKGROUND: In epithelial-to-mesenchymal transition, epithelial cells lose their features, acquiring a mesenchymal-like phenotype. Nm23-H1 protein relates to tumor cells' metastatic potential, its low expression in carcinomas often meaning a poor prognosis. This study newly investigated the role of nuclear nm23-H1 in laryngeal squamous cell carcinoma epithelial-to-mesenchymal transition. METHODS: Immunohistochemical analyses of nuclear nm23-H1, E-cadherin, N-cadherin, Snail, Zinc finger E-box binding homeobox (ZEB)1, and ZEB2 were performed in 33 consecutive patients with laryngeal SCC...
June 28, 2018: Head & Neck
J Kenneth Byrd, Jon Mallen-St Clair, Ivan El-Sayed
This article is a continuation of the "Do You Know Your Guidelines" series. This was launched as an initiative of the American Head and Neck Society to increase the awareness of current best practices pertaining to head and neck cancer. The National Comprehensive Cancer Network (NCCN) guidelines for managing cancer of the paranasal sinuses are reviewed in a systematic fashion. These guidelines outline the workup, treatment, and surveillance of patients with cancer of the maxillary and ethmoid sinuses...
June 27, 2018: Head & Neck
Suhas Kodasoge Rajappa, Dharma Ram, Yogendra Singh Bhakuni, Ankita Jain, Rajeev Kumar, Ajay K Dewan
BACKGROUND: With the introduction of new American Joint Committee on Cancer (AJCC) classifications for head and neck cancers few cases are upgraded from T2 to T3 based only on depth of invasion. The role of adjuvant therapy in this particular subset of patients is still not defined. METHODS: This is a retrospective analysis of data from 2009 to 2015, of patients with histopathology of pT1, T2, and N0. A total of 375 patients were subdivided into 3 groups per the new AJCC classification depth of invasion <5 mm, 6 to 10 mm, and >10 mm...
June 26, 2018: Head & Neck
Hakan Coskun, William M Mendenhall, Alessandra Rinaldo, Juan P Rodrigo, Carlos Suárez, Primož Strojan, Fernando López, Vanni Mondin, Nabil F Saba, Ashok R Shaha, Robert Smee, Robert P Takes, Alfio Ferlito
It is traditionally accepted that subglottic carcinoma has a worse prognosis than tumors arising in other subsites of the larynx, owing to its tendency to present in advanced stages, with a high incidence of cartilage invasion and extralaryngeal spread. The incidence of subglottic carcinoma varies among series, mainly because there is no uniform definition of the upper boundary of the subglottis. The extent of the tumor may be difficult to define because subglottic carcinoma may spread through the submucosa without visible mucosal changes...
June 26, 2018: Head & Neck
Cheng Wu, Shan Peng, Wei Sun, Min Luo, Beibei Su, Dongbo Liu, Guoqing Hu
BACKGROUND: Various studies have assessed the association between E-cadherin methylation and risk of nasopharyngeal cancer (NPC) but the conclusion remains unclear. This meta-analysis was conducted to evaluate the effects of E-cadherin methylation on the incidence and clinicopathological characteristics of NPC. METHODS: Ten studies published up to June 30, 2016, were collected. Odds ratios (ORs) with corresponding confidence intervals (CIs) were calculated and summarized, respectively...
June 26, 2018: Head & Neck
Shin Saito, Hiroyuki Ozawa, Masato Fujioka, Keigo Hikishima, Junichi Hata, Sho Kurihara, Hirotaka James Okano, Kaoru Ogawa
BACKGROUND: Precise imaging of nerves have been challenging in the head and neck region, mainly due to low spatial resolution. Here, we investigated how nerves in the head and neck region could be visualized using an ultra-high magnetic field MR system. METHODS: We used formol-carbol-fixed human cadaveric necks and obtained MR diffusion tensor images (DTIs) using a 9.4 Tesla (T) ultra-high magnetic field MR system. Afterward, we prepared tissue sections and checked the anatomic relationships between the neurons and the carotid artery in order to confirm that the visualized fibers are indeed neuron fibers...
June 26, 2018: Head & Neck
Adrien Russel, Duc Trung Nguyen, Charlène Vigouroux, Patrice Gallet, Jean-Michel Vignaud, Cécile Rumeau, Roger Jankowski
BACKGROUND: The purpose of this study was to describe the pathology of the different compartments in endoscopic resection of nasal intestinal-type adenocarcinomas (ITACs) and its relationships with oncologic outcomes. METHODS: This retrospective study included all patients endoscopically operated for nasal ITACs, followed by radiotherapy in the majority of cases, between 2004 and 2014. The surgery systematically separated 3 compartments: ethmoid lateral mass, olfactory cleft, and anterior cranial fossa (in cases with skull-base invasion) to analyze their pathological "focal" or "massive" invasion by the tumor...
June 26, 2018: Head & Neck
Carol M Lewis, Gaurav S Ajmani, Alexandra Kyrillos, Paul Chamberlain, Chi-Hsiung Wang, Cheryl C Nocon, Monica Peek, Mihir K Bhayani
BACKGROUND: Definitive surgery is recommended for oral cavity squamous cell carcinoma (SCC). The purpose of this study was to present our assessment of the disparities in treatment selection for oral cavity SCC. METHODS: Non-Hispanic white and non-Hispanic black patients with oral cavity SCC were identified in the National Cancer Database (NCDB). Regression models were used to estimate relative risk (RR) of receiving surgery and absolute difference between non-Hispanic white and non-Hispanic black patients...
June 26, 2018: Head & Neck
Robert L Ferris, Yuri Nikiforov, Davis Terris, Raja R Seethala, J Andrew Ridge, Peter Angelos, Quan-Yang Duh, Richard Wong, Mona M Sabra, James A Fagin, Bryan McIver, Victor J Bernet, R Mack Harrell, Naifa Busaidy, Edmund S Cibas, William C Faquin, Peter Sadow, Zubair Baloch, Maisie Shindo, Lisa Orloff, Louise Davies, Gregory W Randolph
The newly introduced pathologic diagnosis of noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) will result in less bilateral thyroid surgery as well as deescalation in T4 suppressive and radioactive iodine treatment. Although, NIFTP is a nonmalignant lesion that has nuclear features of some papillary malignancies, the challenge for the surgeon is to identify a lesion as possibly NIFTP before the pathologic diagnosis. NIFTP, due to its reduction of overall rates of malignancy, will result in the initial surgical pendulum swinging toward lobectomy instead of initial total thyroidectomy...
June 26, 2018: Head & Neck
Young Ki Lee, Kyeong Hye Park, Se Hee Park, Kwang Joon Kim, Dong Yeob Shin, Kee Hyun Nam, Woong Youn Chung, Eun Jig Lee
BACKGROUND: Diffuse lymphocytic infiltration (DLI) is frequently found with papillary thyroid cancer (PTC), so there has been long interest in how it affects the characteristics of PTC. This purpose of this study was to define the association between DLI and PTC aggressiveness according to thyroperoxidase antibody (TPOAb) and B-type Raf (BRAF)V600E mutation positivity. METHODS: There were 1879 patients with PTC who underwent surgery and were enrolled in this study...
June 22, 2018: Head & Neck
Amanda R Kahl, Mary E Charlton, Nitin A Pagedar, Steven M Sperry, Bobbi Matt, Charles Platz, Charles F Lynch
BACKGROUND: Surveillance, Epidemiology, and End Results Cancer Registries (SEER) began collecting human papillomavirus (HPV) status for upper aerodigestive tract cancers in 2010. However, classification of p16-testing was not included in the Collaborative Stage coding guidelines, potentially leading to inconsistent coding. METHODS: The HPV values for Iowa patients with oropharyngeal cancers (n = 824) were recoded based on modified guidelines that included p16 test results, and compared with the original guidelines...
June 22, 2018: Head & Neck
Nicole L Lebo, Rebecca Griffiths, Stephen Hall, Jim Dimitroulakos, Stephanie Johnson-Obaseki
BACKGROUND: Preclinical and early-phase clinical studies have suggested an oncoprotective role of statins in head and neck squamous cell carcinoma (HNSCC). The purpose of this study was to determine whether incidental statin use in patients with human papillomavirus (HPV)-negative HNSCC is predictive of improved oncologic outcomes. METHODS: A retrospective cohort study of 1194 patients from the Ontario Cancer Registry diagnosed with HNSCC from 2007 to 2012 was performed using linked databases from the Institute for Clinical Evaluative Sciences...
June 22, 2018: Head & Neck
Yasiru G Karunaratne, Dakshika A Gunaratne, Michael J Veness
BACKGROUND: Merkel cell carcinoma (MCC) is a rare and aggressive cutaneous neuroendocrine tumor arising on the head and neck in 40%-50% of patients. Between 20% and 40% will harbor subclinical nodal metastasis. METHODS: Using search terms 'Merkel AND sentinel', MEDLINE, PUMED, and EMBASE databases were systematically reviewed for publications regarding sentinel lymph node biopsy (SLNB) in classification I and II MCC of the head and neck. RESULTS: Twenty-nine publications encompassing 136 patients were included...
June 22, 2018: Head & Neck
Benoît Morisod, Anne-Claude Guinchard, Philippe Gorphe, Valerie Schweizer, Kishore Sandu, Christian Simon
BACKGROUND: We report on the feasibility and functional outcome of transoral robotic (TORS) supracricoid partial laryngectomy (SCPL) with cricohyoidoepiglottopexy (CHEP). METHODS: Cadaveric studies and functional outcome at 3 years using the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC-QLQ-H&N35), the Functional Outcome Swallowing Scale (FOSS), the Performance Status Scale for Head and Neck Cancer (PSS-HN), computerized voice analysis, and videotape recordings...
June 22, 2018: Head & Neck
Dakshika A Gunaratne, Evan A Tseros, Zubair Hasan, Akshay S Kudpaje, Anand Suruliraj, Mark C Smith, Faruque Riffat, Carsten E Palme
BACKGROUND: Cervical necrotizing fasciitis is a progressive soft tissue infection with significant morbidity and mortality. METHODS: A case review of cervical necrotizing fasciitis managed at our institution (2007-2017) and a systematic review of PubMed, MEDLINE, and EMBASE databases using the algorithm "(cervical OR neck) AND necrotizing fasciitis." RESULTS: There were 1235 cases from 207 articles which were included in our clinical review...
June 22, 2018: Head & Neck
Maheer M Masood, Massimiliano Di Giosia, Trevor G Hackman
BACKGROUND: First bite syndrome is a well-recognized complication of parapharyngeal space surgery. There are no reported cases of protracted first bite syndrome and subsequent diagnosis of a primary squamous cell carcinoma (SCC) of the parotid. METHODS: We present the case of a 73-year-old man with no surgical history and 9 years of first bite syndrome who was ultimately diagnosed with a primary SCC of the parotid. Diagnostic workup, including MRI and biopsy, along with oncologic treatment, were performed...
June 21, 2018: Head & Neck
Marc Lucas Ooft, Jolique van Ipenburg, Rob J M van de Loo, Rick de Jong, Cathy B Moelans, Remco de Bree, Martine J de Herdt, Senada Koljenović, R Baatenburg de Jong, J Hardillo, Stefan Martin Willems
BACKGROUND: Nasopharyngeal carcinoma (NPC) treatment is mainly based on clinical staging. We hypothesize that better understanding of the molecular heterogeneity of NPC can aid in better treatment decisions. Therefore, the purpose of this study was to present our exploration of cancer gene copy-number alterations (CNAs) of Epstein-Barr virus (EBV)-positive and EBV-negative NPC. METHODS: Multiplex ligation-dependent probe amplification was applied to detect CNAs of 36 cancer genes (n = 103)...
June 21, 2018: Head & Neck
Paul Georg Werthmann, Roman Huber, Gunver Sophia Kienle
BACKGROUND: Skull metastases are rare, they can eventually cause pain, and can invade the brain. Viscum album extracts (VAEs) are used as an adjuvant treatment in cancer. METHODS AND RESULTS: A 68-year-old patient with rectal cancer presented with lung metastases, and metastases to multiple bone sites, the chest wall, and the liver were later identified. Histological examination of one of the bone lesions revealed an additional thyroid carcinoma. An osteolytic parietal bone lesion progressed to a painful metastasis of the skull despite radiotherapy and chemotherapy...
June 9, 2018: Head & Neck
Rabeia Almahmoudi, Abdelhakim Salem, Meri Sieviläinen, Elias Sundquist, Alhadi Almangush, Sanna Toppila-Salmi, Timo Paavonen, Tuula Salo, Ahmed Al-Samadi
BACKGROUND: Oral tongue squamous cell carcinoma (SCC) is characterized by early metastasis and poor prognosis. Interleukin-17F (IL-17F) plays a protective role in many tumors. However, IL-17F expression in oral tongue SCC tissue has not been investigated. METHODS: Immunostaining of 83 oral tongue SCC specimens and blinded-scoring were used to map IL-17F expression, location, and distribution. Survival curves were constructed according to Kaplan-Meier method. The Cox proportional hazard model was applied for univariate and multivariate survival analyses...
May 14, 2018: Head & Neck
Tristan Tham, Yonatan Bardash, Saori Wendy Herman, Peter David Costantino
BACKGROUND: The purposes of this systematic review and meta-analysis were to investigate the relationship between the neutrophil-to-lymphocyte ratio (NLR) and prognosis in head and neck cancer. METHODS: A systematic review and meta-analysis were done to investigate the role of NLR in overall survival (OS), disease-specific survival (DSS), disease-free survival (DFS), and progression-free survival (PFS). RESULTS: For qualitative analysis, 33 cohorts with over 10 072 patients were included...
May 14, 2018: Head & Neck
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