journal
MENU ▼
Read by QxMD icon Read
search

Head & Neck

journal
https://www.readbyqxmd.com/read/28644558/current-understanding-of-cancer-stem-cells-review-of-their-radiobiology-and-role-in-head-and-neck-cancers
#1
REVIEW
Paul Ambrose Reid, Puthenparampil Wilson, Yanrui Li, Loredana Gabriela Marcu, Eva Bezak
Evidence of cancer cells that bear attributes analogous to those of normal stem cells has developed a hierarchical model of cancer's architecture and progression. This subset of cancer stem cells (CSCs) drives the progression and therapy resistance of cancers. Research to identify the phenotypes of these CSCs presents evidence of a subpopulation that is more resistant to therapy and may proliferate in response. Literature shows that CSCs typically represent around 1%-10% of cell populations in head and neck cancer but this proportion may increase in response to a therapeutic radiation dose...
June 23, 2017: Head & Neck
https://www.readbyqxmd.com/read/28644552/assessment-of-videofluoroscopic-swallow-study-findings-before-and-after-cricopharyngeal-myotomy
#2
Jacqui Allen, Dora Blair, Anna Miles
BACKGROUND: Cricopharyngeal myotomy is a treatment for obstructive cricopharyngeal bar and Zenker's diverticulitis. Little is reported regarding contrast study findings and their correlation with patient symptoms. METHODS: All patients treated by cricopharyngeal myotomy underwent a preoperative and postoperative videofluoroscopic swallow study (VFSS) and completed the self-reported Eating Assessment Tool (EAT-10). Studies were analyzed quantitatively. RESULTS: Forty cricopharyngeal myotomies were performed (mean age 76 years; SD 8...
June 23, 2017: Head & Neck
https://www.readbyqxmd.com/read/28644540/cytokeratin-19-expression-in-early-oral-squamous-cell-carcinoma-and-their-metastasis-inadequate-biomarker-for-one-step-nucleic-acid-amplification-implementation-in-sentinel-lymph-node-biopsy-procedure
#3
Rob Noorlag, Robert J J van Es, Remco de Bree, Stefan M Willems
BACKGROUND: Intraoperative analysis of lymph nodes during a sentinel lymph node biopsy (SLNB) procedure could result in one-step surgery for early oral squamous cell carcinoma (OSCC) with an occult nodal metastasis. One-step nucleic acid amplification rapidly detects cytokeratin 19 (CK19) RNA with high accuracy. Sensitivity and specificity of CK19 expression in OSCC was evaluated. METHODS: Immunohistochemical CK19 expression was done in 207 patients with OSCC with 65 cases of paired nodal metastases...
June 23, 2017: Head & Neck
https://www.readbyqxmd.com/read/28640533/high-risk-squamous-cell-carcinoma-of-the-ear-a-potential-role-for-sentinel-node-biopsy
#4
Suzanne Beecher, Paula F Wrafter, Cormac W Joyce, Padraic J Regan, Jack L Kelly
BACKGROUND: Squamous cell carcinomas (SCCs) of the external ear have a significant rate of metastasis. The purpose of this study was to present analyzed factors associated with auricular SCC metastasis in order to identify a group that may benefit from sentinel lymph node biopsy (SLNB). METHODS: We performed a retrospective review of all operable SCCs between 2009 and 2014. The association between high-risk features and metastasis were analyzed. RESULTS: One hundred eighty-nine auricular SCCs were excised...
June 22, 2017: Head & Neck
https://www.readbyqxmd.com/read/28640498/management-of-proliferative-verrucous-leukoplakia-justification-for-a-conservative-approach
#5
Scott C Borgna, Peter T Clarke, Andrew G Schache, Derek Lowe, Michael W Ho, Caroline E McCarthy, Stephen Adair, E Anne Field, John K Field, Deborah Holt, Janet M Risk, Bijay P Rajlawat, Asterios Triantafyllou, Richard J Shaw
BACKGROUND: Proliferative verrucous leukoplakia (PVL) is a progressive, multifocal, exophytic form of leukoplakia with high rates of malignant transformation. The purpose of this study was to evaluate a cohort of patients with PVL in a single tertiary referral clinic. METHOD: Cases meeting accepted diagnostic criteria were reviewed with regard to their pathology, demographic characteristics, management, and outcomes. Human papillomavirus (HPV) testing was undertaken on a subset...
June 22, 2017: Head & Neck
https://www.readbyqxmd.com/read/28640483/decreased-cancer-independent-life-expectancy-in-the-head-and-neck-cancer-population
#6
Sean T Massa, Lauren M Cass, Nosayaba Osazuwa-Peters, Kara M Christopher, Ronald J Walker, Mark A Varvares
BACKGROUND: Aside from cancer mortality, patients with head and neck cancer have increased mortality risk. Identifying patients with the greatest loss of cancer-independent life expectancy can guide comprehensive survivorship programs. METHODS: Age-based survival data from the Surveillance, Epidemiology, and End Result (SEER) database for patients with head and neck cancer were censored for mortality from the index cancer. Life expectancy and years of life lost (YLL) referenced to the general population were calculated...
June 22, 2017: Head & Neck
https://www.readbyqxmd.com/read/28640478/usefulness-of-office-examination-with-narrow-band-imaging-for-the-diagnosis-of-head-and-neck-squamous-cell-carcinoma-and-follow-up-of-premalignant-lesions
#7
Isabel Vilaseca, Meritxell Valls-Mateus, Anna Nogués, Eduardo Lehrer, Mauricio López-Chacón, Francesc Xavier Avilés-Jurado, José Luis Blanch, Manuel Bernal-Sprekelsen
BACKGROUND: The purpose of this study was to evaluate the value of narrow band imaging (NBI) examination in the office for the diagnosis and follow-up of upper airway premalignant and malignant lesions. METHODS: Four hundred eighty lesions were evaluated with white light endoscopy (WLE) and NBI before a biopsy/excision. Additionally, 151 premalignant lesions were followed up without proven biopsy. Carcinoma-free survival was calculated. The learning curve was analyzed...
June 22, 2017: Head & Neck
https://www.readbyqxmd.com/read/28640471/prognostic-significance-of-cystic-lymph-nodal-metastasis-in-nasopharyngeal-carcinoma
#8
Yohanes Ting, Jeremy Chee, Tze Choong Charn, Kwok Seng Loh, Chih Ching Choong, Eric Ting, Chwee Ming Lim
BACKGROUND: The purpose of this study was to determine the prevalence of cystic lymph nodal metastasis (CLNM) and its prognostic value in patients with nasopharyngeal carcinoma (NPC). METHODS: A retrospective review was conducted on 257 patients with NPC, analyzing the presence of CLNM on MRI or CT scans. Oncologic outcomes were performed using the Kaplan-Meier analysis. RESULTS: One hundred eleven patients (43.2%) had CLNM at diagnosis. Overall, patients with CLNM had a poorer disease-specific survival (DSS; P < ...
June 22, 2017: Head & Neck
https://www.readbyqxmd.com/read/28631342/efficacy-of-a-high-observation-protocol-in-major-head-and-neck-cancer-surgery-a-prospective-study
#9
Brittany Barber, Jeffrey Harris, Cameron Shillington, Shannon Rychlik, Joseph Dort, Michael Meier, Angela Estey, Adam Elwi, Patty Wickson, Michael Buss, David Zygun, Kal Ansari, Vincent Biron, Daniel O'Connell, Hadi Seikaly
BACKGROUND: The purpose of this study was to optimize an existing clinical care pathway (CCP) for head and neck cancer with a high-observation protocol (HOP) and to determine the effect on length of intensive care unit (ICU) admission and length of stay in hospital (LOS). METHODS: The HOP mandated initiation of spontaneous breathing trials before the conclusion of the surgery, weaning of sedation, and limiting mechanical ventilation. All patients with head and neck cancer undergoing primary surgery on the HOP were compared to a historical cohort regarding length of ICU admission, ICU readmissions, and LOS...
June 20, 2017: Head & Neck
https://www.readbyqxmd.com/read/28593742/overview-of-surgery-for-laryngeal-and-hypopharyngeal-cancer-in-ontario-2003-2010
#10
Antoine Eskander, Matthew Mifsud, Jonathan Irish, Patrick Gullane, Ralph Gilbert, Dale Brown, John R de Almeida, David R Urbach, David P Goldstein
BACKGROUND: The primary purpose of this study was to describe variations in incidence rates, resections rates, and types of surgical resection for patients diagnosed with laryngeal and hypopharyngeal cancers in Ontario. METHODS: All laryngeal and hypopharyngeal cancer cases in Ontario (2003-2010) were identified from the Ontario Cancer Registry (n = 3034). Variations in incidence rates, resection rates, and type of surgical resection were compared by sex, age group, neighborhood income, community population, health region, and physician specialty...
June 7, 2017: Head & Neck
https://www.readbyqxmd.com/read/28593651/outcomes-for-patients-with-synchronous-and-metachronous-primary-lung-cancer-after-diagnosis-of-head-and-neck-cancer
#11
Babak Tamjid, Phuong Phan, Thomas John, Paul Mitchell, Hui Gan
BACKGROUND: Not-infrequently patients with head and neck cancer are also diagnosed with synchronous lung cancer or metachronous primary lung cancer, which complicates the treatment decisions and prognosis. METHODS: Patients were identified from a database of patients with head and neck cancer with second primary non-small cell lung cancer (NSCLC). RESULTS: Thirty-four eligible patients (15 with synchronous lung cancer and 19 with metachronous lung cancer) were identified...
June 7, 2017: Head & Neck
https://www.readbyqxmd.com/read/28586138/postoperative-radiotherapy-dose-requirement-in-standard-combined-modality-practice-for-head-and-neck-squamous-cell-carcinoma-analysis-of-salient-surgical-and-radiotherapy-parameters-in-2-cohorts
#12
Bidhu K Mohanti, Alok Thakar, Jaspreet Kaur, Sudhir Bahadur, Monica Malik, Ajeet K Gandhi, Suman Bhasker, Atul Sharma
BACKGROUND: This study compared 2 sequential cohorts to identify the postoperative radiotherapy (PORT) dose requirement for head and neck squamous cell carcinoma (HNSCC). METHODS: Two distinct PORT dose regimens were prescribed over 11 years; group 1 received 56 Gy or less, and group 2 received 60 Gy or more. The 2D and 3D techniques were used. RESULTS: Two sequential cohorts consisted of 478 patients, with mean and median follow-up for group 1 and 2 as: 37...
June 6, 2017: Head & Neck
https://www.readbyqxmd.com/read/28580768/ahns-series-do-you-know-your-guidelines-lip-cancer
#13
William Dougherty, Babak Givi, Mark J Jameson
BACKGROUND: Lip cancer is one of the most curable primary head and neck malignancies, as the prominent location typically lends to an early diagnosis. The incidence of lip cancer varies by sex, ethnicity, and region, but is estimated to be up to 2.5/100 000 in the United States (squamous cell carcinoma [SCC]). METHODS: This article will review the current literature and National Comprehensive Cancer Network practice guidelines in the treatment of lip cancer. RESULTS: Resection of lip cancer with negative margins remains the mainstay of therapy...
June 5, 2017: Head & Neck
https://www.readbyqxmd.com/read/28580729/laparoscopic-harvest-of-the-gastro-omental-free-flap-for-reconstruction-after-total-pharyngolaryngectomy-operative-technique
#14
Steven J Craig, Alexander Zhang, Trevor D Gardner, Jonathan R Clark, Bruce G Ashford
Circumferential defects following salvage pharyngolaryngectomy present significant challenges in reconstructive surgery. The gastro-omental free flap has been shown to reduce the incidence of major fistula and catastrophic complications. The current technique for harvest of the flap requires laparotomy, which is potentially associated with significant post-operative complications. Laparoscopic harvest of the gastro-omental free flap can negate some of the risks associated with open surgery. We describe here the operative technique for laparoscopic gastro-omental free flap harvest for use in reconstruction following total pharyngolaryngectomy...
June 5, 2017: Head & Neck
https://www.readbyqxmd.com/read/28580699/prognostic-value-of-lymphovascular-invasion-of-the-primary-tumor-in-hypopharyngeal-carcinoma-after-total-laryngopharyngectomy
#15
Yuki Saito, Go Omura, Kazuo Yasuhara, Ryoko Rikitake, Ken Akashi, Osamu Fukuoka, Masafumi Yoshida, Mizuo Ando, Takahiro Asakage, Tatsuya Yamasoba
BACKGROUND: We aimed to determinate the prognostic value of lymphovascular invasion in the specimens resected during total laryngopharyngectomy for hypopharyngeal carcinoma. METHODS: Patients who underwent total laryngopharyngectomy at our institution between 2004 and 2014 were included in this study and retrospectively analyzed. We then discriminated for vascular invasion and lymphatic invasion of the primary tumor in all cases. RESULTS: We reviewed 135 records (120 men and 15 women; age range, 36-84 years)...
June 5, 2017: Head & Neck
https://www.readbyqxmd.com/read/28580621/functional-outcomes-of-fasciocutaneous-free-flap-and-pectoralis-major-flap-for-salvage-total-laryngectomy
#16
Sally Nguyen, François Thuot
BACKGROUND: Pectoralis major muscle flaps (PMMFs) and fasciocutaneous free flaps (FFFs) are commonly used for reconstruction of the surgical defect after salvage total laryngectomy. This study compared swallowing function in patients who underwent reconstruction with either PMMF or FFF. METHODS: This study was based on a retrospective cohort of patients treated at the CHU de Québec between January 2000 and March 2015. Demographics, chemoradiation data, surgical protocol, pathologic results, complications, evolution, esophageal dilation, diet intake, and feeding tube dependence were documented...
June 5, 2017: Head & Neck
https://www.readbyqxmd.com/read/28580605/morphologic-and-topographic-radiologic-features-of-human-papillomavirus-related-and-unrelated-oropharyngeal-carcinoma
#17
Michael W Chan, Eugene Yu, Eric Bartlett, Brian O'Sullivan, Jie Su, John Waldron, Jolie Ringash, Scott V Bratman, Yingming Amy Chen, Jonathan Irish, John Kim, Patrick Gullane, Ralph Gilbert, Douglas Chepeha, Bayardo Perez-Ordonez, Ilan Weinreb, Aaron Hansen, Li Tong, Wei Xu, Shao Hui Huang
BACKGROUND: The purpose of this study was to compare the clinicoradiologic characteristics of human papillomavirus (HPV)-related (HPV-positive) and HPV-unrelated (HPV-negative) oropharyngeal carcinoma (OPC). METHODS: Primary tumor and lymph node features of HPV-positive and HPV-negative OPCs from 2008 to 2013 were compared on pretreatment CT/MRI. Intrarater/interrater concordance was assessed. Multivariable analyses identified factors associated with HPV-positivity to be used in nomogram construction...
June 5, 2017: Head & Neck
https://www.readbyqxmd.com/read/28580594/multiple-single-nucleotide-polymorphism-analysis-and-association-of-specific-genotypes-in-fhit-samd4a-and-ankrd17-in-indian-patients-with-oral-cancer
#18
Wendy D'Souza, Sultan Pradhan, Dhananjaya Saranath
BACKGROUND: Oral cancer has a high incidence primarily because of tobacco chewing habits. However, a small proportion of habitués develop oral cancer, implying a role for genomic variants in its susceptibility. METHODS: Thirteen single nucleotide polymorphisms (SNPs) in an Indian cohort comprising patients with oral cancer (n = 500) and healthy controls (n = 500) were genotyped using allelic discrimination real-time polymerase chain reaction (PCR). RESULTS: Prevalence of SNPs rs11130760, rs1957358, rs2306058, rs4883543, rs12637722, rs1457115, rs2353292, rs709821, rs2194861, rs4789378, rs3827538, rs2667552, and rs2886093 was determined in the Indian cohort...
June 5, 2017: Head & Neck
https://www.readbyqxmd.com/read/28570011/effect-of-transcervical-arterial-ligation-on-the-severity-of-postoperative-hemorrhage-after-transoral-robotic-surgery
#19
Mark Kubik, Rajarsi Mandal, William Albergotti, Umamaheswar Duvvuri, Robert L Ferris, Seungwon Kim
BACKGROUND: The value of transcervical arterial ligation during transoral robotic surgery (TORS) as a measure to decrease postoperative bleeding incidence or severity is unclear. METHODS: A retrospective single institution study was performed to identify risk factors for hemorrhage after TORS for oropharyngeal squamous cell carcinoma (SCC). RESULTS: Overall, 13.2% of patients (35/265) experience postoperative hemorrhage. T classification, perioperative use of anticoagulants, surgeon experience >50 cases, and tumor subsite were not predictors of postoperative hemorrhage...
June 1, 2017: Head & Neck
https://www.readbyqxmd.com/read/28561956/outcomes-for-olfactory-neuroblastoma-treated-with-induction-chemotherapy
#20
Shirley Y Su, Diana Bell, Renata Ferrarotto, Jack Phan, Dianna Roberts, Michael E Kupferman, Steven J Frank, C Dave Fuller, G Brandon Gunn, Merrill S Kies, Bonnie S Glisson, Ehab Y Hanna
BACKGROUND: Oncologic outcomes for induction chemotherapy and its role in patients with advanced olfactory neuroblastoma (ONB) remain unclear. METHODS: A retrospective review of 15 consecutive patients with extensive local invasion and/or nodal disease treated with induction chemotherapy with curative intent followed by definitive local therapy. RESULTS: The majority of patients were treated with cisplatin and etoposide. The response to chemotherapy was 68% (10/15)...
May 31, 2017: Head & Neck
journal
journal
30036
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"