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Head & Neck

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https://www.readbyqxmd.com/read/28872214/quality-of-life-after-thyroidectomy-in-patients-with-nontoxic-nodular-goiter-a-prospective-cohort-study
#1
Jesper Roed Sorensen, Torquil Watt, Per Cramon, Helle Døssing, Laszlo Hegedüs, Steen Joop Bonnema, Christian Godballe
BACKGROUND: Using the thoroughly validated Thyroid-Related Quality-of-Life Patient-Reported Outcome (ThyPRO) questionnaire, the purpose of this study was to investigate changes in disease-specific quality of life (QOL) after surgical treatment in patients with benign nontoxic multinodular goiters. METHOD: Patients with goiters scheduled for thyroid surgery (n = 106) and individuals from the general population (n = 739) were studied. The ThyPRO data before, 3 months, and 6 months after surgery were compared with normative scores from the general population using a linear mixed model and t tests...
September 4, 2017: Head & Neck
https://www.readbyqxmd.com/read/28842932/clinicopathological-characteristics-and-outcomes-of-squamous-cell-carcinoma-of-the-tongue-in-different-age-groups
#2
Yan-Yan Zhang, Dian-Can Wang, Jia-Zeng Su, Ling-Fei Jia, Xin Peng, Guang-Yan Yu
BACKGROUND: The clinicopathological features and outcomes of squamous cell carcinoma (SCC) of the tongue in patients of different age groups remain debatable. METHODS: Medical records of 457 patients with tongue SCC were reviewed, grouped by age, followed up, and compared. RESULTS: Sex and TNM stage showed no intergroup differences. Tongue SCC in patients ≤30 years had the most advanced TNM classification and greatest proportion of poorly differentiation tumors...
August 26, 2017: Head & Neck
https://www.readbyqxmd.com/read/28837753/functional-outcomes-and-quality-of-life-after-total-laryngectomy-with-noncircumferential-radial-forearm-free-tissue-transfer
#3
Donna J Graville, Andrew D Palmer, Christine M Chambers, Lauren Ottenstein, Breanne Whalen, Peter E Andersen, Mark K Wax, James I Cohen
BACKGROUND: The purpose of this study was to compare long-term functional and quality of life (QOL) outcomes after total laryngectomy with primary closure and those who underwent reconstruction with noncircumferential radial free forearm tissue transfer (RFFTT). METHODS: Sixty-seven patients were identified by chart review and underwent long-term follow-up using QOL surveys and standardized interviews. RESULTS: The RFFTT group had significantly higher rates of chemotherapy, gastric tube (G-tube) at surgery, and postoperative stricture...
August 24, 2017: Head & Neck
https://www.readbyqxmd.com/read/28833829/long-term-outcome-of-18-f-fluorodeoxyglucose-positron-emission-tomography-guided-dose-painting-for-head-and-neck-cancer-matched-case-control-study
#4
Dieter Berwouts, Indira Madani, Frédéric Duprez, AnaMaria Luiza Olteanu, Tom Vercauteren, Tom Boterberg, Philippe Deron, Katrien Bonte, Wouter Huvenne, Wilfried De Neve, Ingeborg Goethals
BACKGROUND: The purpose of this study was to report the long-term outcome of (18) F-fluorodeoxyglucose-positron emission tomography ((18) F-FDG-PET)-guided dose painting for head and neck cancer in comparison to conventional intensity-modulated radiotherapy (IMRT) in a matched case-control study. METHODS: Seventy-two patients with nonmetastatic head and neck cancer treated with dose painting were compared with 72 control patients matched on tumor site and T classification...
August 21, 2017: Head & Neck
https://www.readbyqxmd.com/read/28833785/benefits-of-initial-ct-staging-before-sentinel-lymph-node-biopsy-in-patients-with-head-and-neck-cutaneous-melanoma
#5
Anna Hafström, Maria Silfverschiöld, Simon S Persson, Michelle Kanne, Christian Ingvar, Peter Wahlberg, Anton Romell, Lennart Greiff
BACKGROUND: The value of CT at the time of diagnosis for patients with cutaneous head and neck melanoma clinically asymptomatic for metastatic disease is unclear. METHODS: A retrospective medical chart review was performed on 198 consecutive patients identified with primary T1b-T4b head and neck melanoma clinically asymptomatic for metastatic disease referred for sentinel lymph node biopsy procedures between 2004 and 2014. RESULTS: Initial CTs identified clinically occult melanoma metastases in 8...
August 21, 2017: Head & Neck
https://www.readbyqxmd.com/read/28815841/response-assessment-after-induction-chemotherapy-for-head-and-neck-squamous-cell-carcinoma-from-physical-examination-to-modern-imaging-techniques-and-beyond
#6
REVIEW
Remco de Bree, Gregory T Wolf, Bart de Keizer, Iain J Nixon, Dana M Hartl, Arlene A Forastiere, Missak Haigentz, Alessandra Rinaldo, Juan P Rodrigo, Nabil F Saba, Carlos Suárez, Jan B Vermorken, Alfio Ferlito
Significant correlations between the response to induction chemotherapy and success of subsequent radiotherapy have been reported and suggest that the response to induction chemotherapy is able to predict a response to radiotherapy. Therefore, induction chemotherapy may be used to tailor the treatment plan to the individual patient with head and neck cancer: following the planned subsequent (chemo)radiation schedule, planning a radiation dose boost, or reassessing the modality of treatment (eg, upfront surgery)...
August 17, 2017: Head & Neck
https://www.readbyqxmd.com/read/28815839/circulating-tumor-cells-in-patients-with-head-and-neck-squamous-cell-carcinoma-feasibility-of-detection-and-quantitation
#7
Tomoyuki Kawada, Hideyuki Takahashi, Koichi Sakakura, Shota Ida, Ikko Mito, Minoru Toyoda, Kazuaki Chikamatsu
BACKGROUND: The purpose of this study was to present our findings that because circulating tumor cells (CTCs) exist in extremely low numbers, their detection and quantification are challenging. METHODS: Peripheral blood samples were collected from 32 patients with head and neck squamous cell carcinoma (HNSCC), and were subjected to the CellSieve Microfiltration Assay using a low-pressure filtration system. The CTCs captured by the filter were stained with an antibody cocktail (anti-cytokeratin (CK) 8, 18, and 19, anti-epithelial cell adhesion molecule (EpCAM), and anti-CD45 antibodies)...
August 17, 2017: Head & Neck
https://www.readbyqxmd.com/read/28815834/innervation-of-the-human-posterior-cricoarytenoid-muscle-by-the-external-branch-of-the-superior-laryngeal-nerve
#8
Mehmet Uludag, Nurcihan Aygun, Kinyas Kartal, Evren Besler, Adnan Isgor
BACKGROUND: The posterior cricoarytenoid muscle is the abductor muscle for the vocal cords and is innerved by the recurrent laryngeal nerve (RLN). The purpose of this study was to present our determination if the external branch of the superior laryngeal nerve (SLN) contributes to the motor innervation of the posterior cricoarytenoid muscle. METHODS: We performed electromyographies (EMGs) via needle electrodes on 47 posterior cricoarytenoid muscles from 28 patients during thyroidectomy (9 lobectomies and 19 total thyroidectomies) with intraoperative neural monitoring...
August 17, 2017: Head & Neck
https://www.readbyqxmd.com/read/28815787/evaluation-of-incidence-significance-and-prognostic-role-of-circulating-tumor-microemboli-and-transforming-growth-factor-%C3%AE-receptor-i-in-head-and-neck-cancer
#9
Marcello Ferretti Fanelli, Thiago Bueno Oliveira, Alexcia Camila Braun, Marcelo Corassa, Emne Ali Abdallah, Ulisses Ribaldo Nicolau, Vanessa da Silva Alves, Daniel Garcia, Vinicius F Calsavara, Luiz Paulo Kowalski, Ludmilla Thomé Domingos Chinen
BACKGROUND: Circulating tumor microemboli (CTM) are clusters of circulating tumor cells (CTCs), involved in metastasis, as also transforming growth factor-β (TGF-β). The purpose of this study was to verify their role in progression-free survival (PFS). METHODS: Blood from patients with locally advanced head and neck squamous cell carcinoma (HNSCC; n = 53) was analyzed in 2 moments. TGF-β receptor I (TGF-βRI) expression was evaluated by immunocytochemistry...
August 17, 2017: Head & Neck
https://www.readbyqxmd.com/read/28815780/prognostic-significance-of-e-cadherin-and-%C3%AE-catenin-expression-in-hpv-negative-oropharyngeal-squamous-cell-carcinomas
#10
Juana M García-Pedrero, Patricia García-Cabo, M Ángeles Villaronga, Francisco Hermida-Prado, Rocío Granda-Díaz, Eva Allonca, Juan P Rodrigo
BACKGROUND: The purpose of this work was to investigate the prognostic significance of E-cadherin and β-catenin expression in surgically treated human papillomavirus (HPV)-negative patients with oropharyngeal squamous cell carcinoma (SCC). METHODS: Consecutive patients with oropharyngeal SCC who underwent surgical treatment between 1990 and 2009 were retrospectively collected. Immunohistochemical analysis of E-cadherin and β-catenin expression was performed on tissue microarrays...
August 17, 2017: Head & Neck
https://www.readbyqxmd.com/read/28815861/radiation-and-chemotherapy-with-no-excessive-toxicity-in-a-patient-with-human-papillomavirus-related-tonsillar-cancer-and-porphyria-cutanea-tarda-case-report-and-literature-review
#11
James K Russo, Annie Braseth
BACKGROUND: Porphyria is a condition of cutaneous photosensitivity. It is unclear if radiotherapy (RT) is safe in patients with porphyria. METHODS: We report a patient case with uncontrolled porphyria cutanea tarda treated with chemoradiation for p16-positive oropharyngeal cancer. Given the scarcity of data on this subject, we also conducted a literature review on the topic of radiation in patients with porphyria. RESULTS: The patient in our study did not experience any unusual acute or late toxicity, despite receiving a high dose of cutaneous radiation...
August 16, 2017: Head & Neck
https://www.readbyqxmd.com/read/28815835/patient-education-materials-assessment-tool-for-laryngectomy-health-information
#12
Kevin Wong, Amir Gilad, Michael B Cohen, Diana N Kirke, Scharukh M Jalisi
BACKGROUND: The decision to undergo laryngectomy carries medical, social, and emotional consequences. This study evaluates the understandability and actionability of current laryngectomy information. METHODS: Laryngectomy-related educational materials from an online search were evaluated using the validated Patient Education Materials Assessment Tool (PEMAT). Reading difficulty was calculated using the Flesch-Kincaid Level, Flesch Reading Ease, Gunning-Fog Index (GFI), Coleman-Liau Index, Automated Readability Index, and Simple Measure of Gobbledygook (SMOG) score...
August 16, 2017: Head & Neck
https://www.readbyqxmd.com/read/28815788/association-between-radioiodine-treatment-for-thyroid-cancer-and-risk-of-stroke
#13
Chun-Yi Lin, Cheng-Li Lin, Yi-Chen Lo, Chia-Hung Kao
BACKGROUND: The purpose of this study was to evaluate the association between radioiodine (I-131) therapy for thyroid cancer and the risk of stroke in Taiwan. METHODS: A total of 10 104 of the patients aged 20 years or older, who were newly diagnosed with thyroid cancer during 2000-2010, were recruited and classified into 2 cohorts according to whether they received I-131 therapy through 1:1 propensity score matching. The cumulative Kaplan-Meier curves for the incidence of stroke in the 2 cohorts were compared using the log-rank test...
August 16, 2017: Head & Neck
https://www.readbyqxmd.com/read/28815781/external-jugular-veno-accompanying-artery-adipofascial-flap-a-novel-and-convenient-flap-for-head-and-neck-reconstruction
#14
Seong Oh Park, Kyung Chan Ahn, Ki Yong Hong, Hak Chang, Nobuaki Imanishi
BACKGROUND: The veno-accompanying artery adipofascial (VAF) flap is nourished by accompanying vessels near large superficial veins. We examined whether the VAF flap can be applied to the external jugular vein. METHODS: Based on anatomic and angiographic studies, we performed reconstructive surgeries using external jugular veno-accompanying artery adipofascial (EJ-VAF) flaps. A retrospective chart review was performed for all patients who underwent this surgery. RESULTS: The presence of arteries accompanying the external jugular vein was confirmed...
August 16, 2017: Head & Neck
https://www.readbyqxmd.com/read/28795453/validation-of-the-modified-4-tiered-categorization-system-through-comparison-with-the-5-tiered-categorization-system-of-the-2015-american-thyroid-association-guidelines-for-classifying-small-thyroid-nodules-on-ultrasound
#15
Ji Hye Lee, Kyunghwa Han, Eun-Kyung Kim, Hee Jung Moon, Jung Hyun Yoon, Vivian Y Park, Jin Young Kwak
BACKGROUND: The purpose of this study was to validate the modified 4-tiered categorization system and to compare stratification of malignancy risk in small thyroid nodules with the 2015 American Thyroid Association (ATA) management guidelines. METHODS: From January 2015 to December 2015, 737 thyroid nodules measured ≥ 1 cm and <2 cm were included in this study. Each nodule was assigned a category with the ultrasonographic patterns described by the 2015 ATA guidelines...
August 10, 2017: Head & Neck
https://www.readbyqxmd.com/read/28786181/survival-and-laryngeal-preservation-tradeoff-in-advanced-laryngeal-cancer-from-the-otorhinolaryngology-patient-to-the-managing-physician
#16
Ollivier Laccourreye, Pierre Bonfils, David Malinvaud, Madeleine Ménard, Philippe Giraud
BACKGROUND: The purpose of this study was to document the tradeoff between survival and laryngeal preservation in advanced-stage laryngeal cancer amenable to chemoradiation or total laryngectomy. METHODS: We conducted a prospective analysis based on a questionnaire completed by 209 laryngeal cancer specialists and 269 volunteers from an otorhinolaryngology clinic. RESULTS: Of the responders, 34.5% would not consider any decrease in survival to preserve their larynx...
August 8, 2017: Head & Neck
https://www.readbyqxmd.com/read/28782304/primary-treatment-for-oropharyngeal-squamous-cell-carcinoma-in-alberta-canada-a-population-based-study
#17
Amy J Hobbs, Nigel T Brockton, T Wayne Matthews, Shamir P Chandarana, Pinaki Bose, Kelly Guggisberg, Gordon H Fick, Joseph C Dort
BACKGROUND: The incidence of human papillomavirus (HPV)-related oropharyngeal squamous cell carcinoma (SCC) is increasing and has better survival than non-HPV related oropharyngeal SCC. This study compared surgical to nonsurgical treatments and demographic, clinical, and survival differences in patients with oropharyngeal SCC, stratified by p16 status. METHODS: We assembled a cohort of adult patients with oropharyngeal SCC diagnosed between 2000 and 2008 in Alberta...
August 7, 2017: Head & Neck
https://www.readbyqxmd.com/read/28782298/transoral-robotic-surgery-for-tonsillar-cancer-addressing-the-contralateral-tonsil
#18
Peter T Dziegielewski, Brian J Boyce, Matthew Old, Theodoros N Teknos, Amit Agrawal, Hafiz Patwa, Enver Ozer
BACKGROUND: The purpose of this study is to determine the incidence and risk factors for bilateral tonsillar cancers treated with transoral robotic surgery (TORS) and to determine the morbidity of the procedure. METHODS: Patients undergoing TORS for known tonsillar cancer were retrospectively reviewed. Perioperative variables and surgical outcomes were analyzed to determine predictive factors for bilateral disease and morbidity rates. RESULTS: Seventy-nine consecutive patients with tonsillar cancers underwent primary TORS radical tonsillectomy...
August 7, 2017: Head & Neck
https://www.readbyqxmd.com/read/28766850/efficacy-of-a-novel-swallowing-exercise-program-for-chronic-dysphagia-in-long-term-head-and-neck-cancer-survivors
#19
Sophie A C Kraaijenga, Lisette van der Molen, Martijn M Stuiver, Robert P Takes, Abrahim Al-Mamgani, Michiel W M van den Brekel, Frans J M Hilgers
BACKGROUND: The efficacy of rehabilitative exercises for chronic dysphagia treatment in head and neck cancer survivors has not been studied extensively and is ambiguous. METHODS: A prospective clinical phase II study using an intensive strength training program was carried out in 17 head and neck cancer survivors with chronic dysphagia. Both swallow and nonswallow exercises were performed for 6-8 weeks with a newly developed tool allowing for progressive muscle overload, including chin tuck, jaw opening, and effortful swallow exercises...
August 2, 2017: Head & Neck
https://www.readbyqxmd.com/read/28766791/symptom-burden-and-patient-characteristics-association-with-quality-of-life-in-patients-with-head-and-neck-cancer-undergoing-radiotherapy
#20
Guro Lindviksmoen Astrup, Tone Rustøen, Kristin Hofsø, Jon Michael Gran, Kristin Bjordal
BACKGROUND: Patients with head and neck cancer (HNC) experience diminished quality of life (QOL) during and after treatment. This study examined which characteristics were associated with QOL over time. METHODS: One hundred thirty-three patients with HNC from a study of 534 oncology patients rated physical and mental QOL using the Short Form-12 5 times from the initiation of radiotherapy (RT) through the following 6 months. Linear mixed model analyses examined changes over time and associated characteristics...
August 2, 2017: Head & Neck
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