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Head & Neck

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https://www.readbyqxmd.com/read/28398688/survival-outcomes-for-cutaneous-angiosarcoma-of-the-scalp-versus-face
#1
Jonathan M Bernstein, Jonathan C Irish, Dale H Brown, David Goldstein, Peter Chung, Albiruni R Abdul Razak, Charles Catton, Ralph W Gilbert, Patrick J Gullane, Brian O'Sullivan
BACKGROUND: The primary purpose of this study was to examine whether angiosarcoma outcomes differ for the scalp and face. METHODS: We conducted a retrospective outcomes analysis of 50 patients with cutaneous angiosarcoma treated by curative intent identified from the Princess Margaret Cancer Centre Registry (from 1958 to 2014). RESULTS: Median survival was 26 months (95% confidence interval [CI], 17.6-34.6) and median follow-up 29 months. For the scalp and face, respectively, the 5-year locoregional control rate was 9% and 53% (p = ...
April 11, 2017: Head & Neck
https://www.readbyqxmd.com/read/28383824/implication-for-second-primary-cancer-from-visible-oral-and-oropharyngeal-premalignant-lesions-in-betel-nut-chewing-related-oral-cancer
#2
Shyun-Yu Liu, I-Jung Feng, Yu-Wei Wu, Ching-Yuan Chen, Chao-Nan Hsiung, Hsueh-Wei Chang, Che-Yi Lin, Min-Te Chang, Hsi-Chien Yu, Sheng-Yang Lee, Ching-Yu Yen
BACKGROUND: Visible oral and oropharyngeal premalignant lesions may be used to monitor for a second primary oral cancer. To control for bias, we focused on the visible oral and oropharyngeal premalignant lesions of patients with oral cancer with a positive betel-nut chewing habit. Visible oral and oropharyngeal premalignant lesions that can predict second primary oral cancers were studied. METHODS: Nine hundred ninety-seven patients with positive betel-nut chewing habits and oral cancer were enrolled in this retrospective cohort study...
April 6, 2017: Head & Neck
https://www.readbyqxmd.com/read/28370900/sinonasal-adenoid-cystic-carcinoma-treatment-outcomes-and-association-with-human-papillomavirus
#3
Eric D Miller, Dukagjin M Blakaj, Benjamin J Swanson, Weihong Xiao, Maura L Gillison, Lai Wei, Aashish D Bhatt, Virginia M Diavolitsis, Jessica L Wobb, Stephen Y Kang, Ricardo L Carrau, John C Grecula
BACKGROUND: The purpose of this study was to review long-term outcomes of sinonasal adenoid cystic carcinoma (ACC) and to clarify its association with human papillomavirus (HPV). METHODS: The medical records of 23 patients with sinonasal ACC treated with primary surgical resection between 1998 and 2013 were reviewed. Tissue specimens were available for 17 patients. The p16 testing was performed using immunohistochemistry (IHC), and HPV infection was determined using quantitative polymerase chain reaction (PCR) with primers targeting the E6/E7 region...
April 3, 2017: Head & Neck
https://www.readbyqxmd.com/read/28370824/systematic-review-of-mammary-analog-secretory-carcinoma-of-salivary-glands-at-7-years-after-description
#4
REVIEW
Bacem A Khalele
BACKGROUND: Mammary analog secretory carcinoma of the salivary glands (MASCSG ) is a newly introduced malignant tumor of the salivary glands. For decades, it has been confused with acinic cell carcinoma (ACC) of the salivary glands. METHODS: All reported cases of MASCSG were surveyed from 2010 until January 2017. The collected data was compiled and computationally processed to describe the clinical parameters of MASCSG . Its epidemiology was also mapped. Moreover, inaccurate data was highlighted...
April 3, 2017: Head & Neck
https://www.readbyqxmd.com/read/28370784/reviewing-the-genetic-alterations-in-high-risk-cutaneous-squamous-cell-carcinoma-a-search-for-prognostic-markers-and-therapeutic-targets
#5
Bruce G Ashford, Jonathan Clark, Ruta Gupta, N Gopalakrishna Iyer, Bing Yu, Marie Ranson
Cutaneous squamous cell carcinoma (SCC) is second only in incidence to basal cell carcinoma (BCC), effecting up to 500 000 people in the United States annually. Metastasis to regional lymph nodes occurs in approximately 5% of cases and imparts significant morbidity. Standard treatment in this group involves a combination of surgery and adjuvant radiation. Currently, there are no clinically useful biomarkers of metastatic potential in primary cutaneous SCC and histological predictors can be unreliable. The high level of mutational burden in normal UV-exposed skin has hampered the search for novel drivers of invasive disease, and indeed metastatic potential...
April 3, 2017: Head & Neck
https://www.readbyqxmd.com/read/28370774/effectiveness-of-incorporating-cetuximab-into-docetaxel-cisplatin-fluorouracil-induction-chemotherapy-and-chemoradiotherapy-for-inoperable-squamous-cell-carcinoma-of-the-oral-cavity-a-phase-ii-study
#6
Peter Mu-Hsin Chang, Hsueh-Ju Lu, Ling-Wei Wang, Shyh-Kuan Tai, Ming-Huang Chen, Pen-Yuan Chu, Muh-Hwa Yang
BACKGROUND: Inoperable oral cavity squamous cell carcinoma (SCC) is a highly invasive disease associated with the extensive destruction of locoregional tissues and a dismal prognosis. Management strategies for these patients are limited. METHODS: This study was a single arm, prospective, open-label phase II trial. A regimen consisting of cetuximab-docetaxel, cisplatin, and fluorouracil (C-TPF) followed by bio-chemoradiotherapy (bio-CRT) with cisplatin and cetuximab was administered to patients who responded to induction chemotherapy...
April 3, 2017: Head & Neck
https://www.readbyqxmd.com/read/28370694/ultra-low-dose-radiotherapy-for-definitive-management-of-ocular-adnexal-b-cell-lymphoma
#7
Chelsea C Pinnix, Bouthaina S Dabaja, Sarah A Milgrom, Grace L Smith, Zeinab Abou, Loretta Nastoupil, Jorge Romaguera, Francesco Turturro, Nathan Fowler, Luis Fayad, Jason Westin, Sattva Neelapu, Michelle A Fanale, Maria A Rodriguez, Frederick Hagemeister, Hun Ju Lee, Yasuhiro Oki, Michael Wang, Felipe Samaniego, Linda Chi, Bita Esmaeli
BACKGROUND: The purpose of this study was to report the response to and toxicity of ultra-low-dose radiotherapy (RT) for B-cell ocular adnexal lymphoma (OAL). METHODS: We conducted a retrospective review of patients with indolent B-cell and mantle cell OAL treated with 4 Gy to the orbit(s) in two 2-Gy fractions. Disease response was assessed clinically and/or radiographically at 2 to 4-month intervals after RT. Data collected included rates of overall response, complete response (CR), partial response (PR), and treatment-related toxic effects...
April 3, 2017: Head & Neck
https://www.readbyqxmd.com/read/28370683/management-of-unilateral-recurrent-laryngeal-nerve-injury-after-thyroid-surgery-a-review
#8
REVIEW
Jeremy Lynch, Rajeev Parameswaran
BACKGROUND: Recurrent laryngeal nerve (RLN) damage because of thyroid and parathyroid surgery has been recognized for over a century. Injury rates have been slowly decreasing in this period while effective treatment strategies have been increasing. METHODS: Recent literature was evaluated on the topics of anatomy, pathophysiology, avoidance, and conservative and surgical treatment of RLN injury. Data for this literature review were identified by PubMed and references from relevant articles using the search terms "thyroid," "laryngeal nerve," and "injury...
April 3, 2017: Head & Neck
https://www.readbyqxmd.com/read/28370649/minimally-invasive-wire-guided-balloon-catheter-puncture-for-voice-prosthesis-insertion
#9
Marc Tobed Secall, Toni Bores, Ignacio Sambola, Joan Lop, Eduardo García Rica, Jordi Lluansi
BACKGROUND: Tracheoesophageal puncture is an effective and reliable method for voice restoration after total laryngectomy that may be performed as a primary or secondary procedure. METHODS: We describe our technique for secondary tracheoesophageal puncture using a wire-guided balloon catheter in an office setting. A 72-year-old patient with a total laryngectomy performed 2 years ago was selected for wire-guided balloon catheter puncture and voice prosthesis insertion...
April 3, 2017: Head & Neck
https://www.readbyqxmd.com/read/28370789/preoperative-vitamin-d-level-as-predictor-of-post-thyroidectomy-hypocalcemia-in-patients-sustaining-transient-parathyroid-injury
#10
Deepa Danan, David C Shonka
BACKGROUND: Several studies have sought to identify predictors of postoperative hypocalcemia after total thyroidectomy; however, there have been conflicting results regarding the impact of preoperative vitamin D deficiency. METHODS: The medical records of patients undergoing total thyroidectomy were retrospectively reviewed. The number of parathyroid glands identified or reimplanted at the time of surgery was used as a marker of transient parathyroid gland damage...
March 29, 2017: Head & Neck
https://www.readbyqxmd.com/read/28370756/systematic-review-and-meta-analysis-of-venous-thromboembolism-in-otolaryngology-head-and-neck-surgery
#11
REVIEW
Sami P Moubayed, Antoine Eskander, Moustafa W Mourad, Sam P Most
BACKGROUND: The purpose of this study was to present our systematic review and meta-analysis of the data on venous thromboembolism (VTE; deep venous thrombosis [DVT] and/or pulmonary embolism [PE]) in otolaryngology-head and neck surgery (OHNS). METHODS: PubMed and Scopus databases were searched for studies reporting VTE in OHNS. Incidence of VTE and bleeding is reported and meta-analyzed overall and for chemoprophylaxis and squamous cell carcinoma (SCC)/free flap subgroups...
March 29, 2017: Head & Neck
https://www.readbyqxmd.com/read/28370753/endocavitary-sonography-of-early-oral-cavity-malignant-tumors
#12
Giuseppe Angelelli, Marco Moschetta, Luisa Limongelli, Annamaria Albergo, Emanuela Lacalendola, Francesco Brindicci, Gianfranco Favia, Eugenio Maiorano
BACKGROUND: Preoperative staging is crucial for oral cancer management. The purpose of this study was to assess the tumor thickness using ultrasound and to correlate the level of histological infiltration with the tumor superficial extension and lesion thickness. METHODS: Thirty-two subjects affected by oral cavity carcinoma were prospectively evaluated with intraoral ultrasound. The ultrasound sensitivity, the correlation between the ultrasound level of infiltration, and lesion diameters and thickness were assessed...
March 29, 2017: Head & Neck
https://www.readbyqxmd.com/read/28370725/impact-of-total-radiotherapy-dose-on-survival-for-head-and-neck-merkel-cell-carcinoma-after-resection
#13
Sagar A Patel, Muhammad M Qureshi, Kimberley S Mak, Debjani Sahni, Nicholas J Giacalone, Waleed Ezzat, Scharukh Jalisi, Minh Tam Truong
BACKGROUND: Head and neck Merkel cell carcinoma (MCC) is commonly treated with surgery and adjuvant radiotherapy (RT) for high-risk features. The optimal radiation dose is unknown. METHODS: One thousand six hundred twenty-five eligible patients with head and neck MCC were identified in the National Cancer Data Base (NCDB). Radiation dose was divided into 3 groups: 30 to <50 Gray (Gy), 50-55 Gy, and >55-70 Gy. Cox regression was used to compare overall survival (OS) between groups, accounting for age, sex, stage, surgery type, margin status, comorbidities, and use of chemotherapy...
March 29, 2017: Head & Neck
https://www.readbyqxmd.com/read/28370672/narrow-band-imaging-in-transoral-laser-surgery-for-early-glottic-cancer-in-relation-to-clinical-outcome
#14
Boudewijn E C Plaat, Manon A Zwakenberg, Joost G van Zwol, Jan Wedman, Bernard F A M van der Laan, György B Halmos, Frederik G Dikkers
BACKGROUND: The purpose of this study was to validate the prognostic value of adding narrow-band imaging (NBI) during transoral laser surgery (TLS) for early glottic cancer. METHODS: In 84 patients, 93 transoral laser resections were performed for carcinoma in situ (Tcis), T1, or T2 glottic cancer. TLS was preceded by intraoperative evaluation using traditional white-light imaging (WLI) in 51 cases. In 42 cases, NBI was used in addition to WLI. Local recurrence rate and recurrence-free survival were retrospectively compared between both groups...
March 29, 2017: Head & Neck
https://www.readbyqxmd.com/read/28370667/improving-outcomes-in-veterans-with-oropharyngeal-squamous-cell-carcinoma-through-implementation-of-a-multidisciplinary-clinic
#15
Tyler Light, Edward El Rassi, Ronald J Maggiore, John Holland, Julie Reed, Kathleen Suriano, Marcelle Stooksbury, Nora Tobin, Neil Gross, Daniel Clayburgh
BACKGROUND: Treatment of head and neck cancer is complex, and a multidisciplinary clinic may improve the coordination of care. The value of a head and neck multidisciplinary clinic has not yet been established in oropharyngeal squamous cell carcinoma (SCC). METHODS: A retrospective review was conducted of Veterans Affairs patients with oropharyngeal SCC undergoing concurrent chemoradiation before and after implementation of the head and neck multidisciplinary clinic...
March 29, 2017: Head & Neck
https://www.readbyqxmd.com/read/28370624/developing-a-risk-stratification-tool-for-audit-of-outcome-after-surgery-for-head-and-neck-squamous-cell-carcinoma
#16
David F Tighe, Alan J Thomas, Isabel Sassoon, Robin Kinsman, Mark McGurk
BACKGROUND: Patients treated surgically for head and neck squamous cell carcinoma (HNSCC) represent a heterogeneous group. Adjusting for patient case mix and complexity of surgery is essential if reporting outcomes represent surgical performance and quality of care. METHODS: A case note audit totaling 1075 patients receiving 1218 operations done for HNSCC in 4 cancer networks was completed. Logistic regression, decision tree analysis, an artificial neural network, and Naïve Bayes Classifier were used to adjust for patient case-mix using pertinent preoperative variables...
March 29, 2017: Head & Neck
https://www.readbyqxmd.com/read/28371063/t1-squamous-cell-carcinoma-of-the-glottis-with-anterior-commissure-involvement-radiotherapy-versus-transoral-laser-microsurgery
#17
Uri Alkan, Yuval Nachalon, Yotam Shkedy, Dan Yaniv, Jacob Shvero, Aron Popovtzer
BACKGROUND: The optimal treatment method of T1 glottic squamous cell carcinoma (SCC) with involvement of the anterior commissure is still debatable. We compared the outcomes of radiotherapy (RT) and transoral laser microsurgery (TLM). METHODS: Data were retrospectively collected for 54 patients who were treated by RT (n = 38) or TLM (n = 16) from 2006 to 2013. RESULTS: No between-group differences were found in demographic or risk factors...
March 28, 2017: Head & Neck
https://www.readbyqxmd.com/read/28371015/p16-ink4a-a-surrogate-marker-of-high-risk-human-papillomavirus-infection-in-squamous-cell-carcinoma-of-the-nasal-vestibule
#18
Domenic Vital, David Holzmann, Gerhard F Huber, Michael B Soyka, Holger Moch, Dieter R Zimmermann, Kristian Ikenberg
BACKGROUND: The purpose of this study was to analyze the role of p16(INK4a) and the prevalence of human papillomavirus (HPV) in squamous cell carcinoma (SCC) of the nasal vestibule. METHODS: Patients diagnosed from 1995 to 2014 were included in this study. Assessment of p16(INK4a) and HPV-DNA polymerase chain reaction (PCR) was performed and analyzed with respect to baseline, clinicopathological, and outcome parameters. The p16(INK4a) positivity was defined as unequivocal nuclear and cytoplasmic staining of ≥70% of the cells, whereas 50%-69% was considered to be a "borderline" result...
March 28, 2017: Head & Neck
https://www.readbyqxmd.com/read/28370782/preoperative-evaluation-and-surgical-planning-of-submandibular-gland-tumors
#19
Timo Atula, Juha Panigrahi, Jussi Tarkkanen, Antti Mäkitie, Katri Aro
BACKGROUND: Roughly half of submandibular gland neoplasms are malignant. Because preoperative information on the nature of these tumors remains limited, both preoperative evaluation and assessment of the extent of primary surgery warrant guidelines that are more accurate. METHODS: We evaluated the preoperative examinations and management of all submandibular gland neoplasms treated surgically at the Helsinki University Hospital between 2000 and 2010. RESULTS: Of the 83 tumors, 58 (70%) were benign and 25 (30%) were malignant...
March 28, 2017: Head & Neck
https://www.readbyqxmd.com/read/28370713/risk-factors-for-and-the-role-of-dental-extractions-in-osteoradionecrosis-of-the-jaws-a-national-based-cohort-study
#20
Ti-Hao Wang, Chia-Jen Liu, Tze-Fan Chao, Tzeng-Ji Chen, Yu-Wen Hu
BACKGROUND: The purpose of this study was to investigate the risk factors, especially the use of certain drugs and the dental procedures, for osteoradionecrosis of the jaw (ORNJ) in patients with head and neck cancer undergoing irradiation as their primary treatment. METHODS: The cohort was composed of 23,527 patients with head and neck cancer. Cox proportional hazard models were used for risk factors analysis. RESULTS: The overall incidence of ORNJ is 3...
March 28, 2017: Head & Neck
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