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Head & Neck

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https://www.readbyqxmd.com/read/29210145/squamous-cell-carcinoma-of-unknown-primary-of-the-head-and-neck-favorable-prognostic-factors-comparable-to-those-in-oropharyngeal-cancer
#1
Margaret J Zhou, Annemieke van Zante, Ann A Lazar, Eli R Groppo, Adam A Garsa, William R Ryan, Ivan H El-Sayed, David W Eisele, Sue S Yom
BACKGROUND: Treatment for squamous cell carcinoma (SCC) of unknown primary consists of radiotherapy (RT) +/- chemotherapy or neck dissection +/- adjuvant RT/chemoradiotherapy (CRT). We compared these strategies and identified prognostic factors. METHODS: From 1993 to 2015, 75 patients with SCC of unknown primary had RT-based or surgery-based treatment. Primary endpoints were overall survival (OS) and disease-free survival (DFS). Event-time distributions were estimated using the Kaplan-Meier method...
December 6, 2017: Head & Neck
https://www.readbyqxmd.com/read/29206328/nutritional-and-hematologic-markers-as-predictors-of-risk-of-surgical-site-infection-in-patients-with-head-and-neck-cancer-undergoing-major-oncologic-surgery
#2
Ho-Jin Son, Jong-Lyel Roh, Seung-Ho Choi, Soon Yuhl Nam, Sang Yoon Kim
BACKGROUND: Surgical site infection is a complication of surgery for patients with head and neck cancer. We examined the risk factors for surgical site infection in patients undergoing surgery for head and neck cancer. METHODS: The study involved 369 patients who underwent surgery for head and neck cancer. Hematological and nutritional parameters were measured preoperatively and postoperatively. Univariate and multivariate analyses were used to determine the risk factors for surgical site infection...
December 5, 2017: Head & Neck
https://www.readbyqxmd.com/read/29206327/pharyngeal-perforation-after-anterior-cervical-spine-surgery-treated-by-transoral-endoscopic-surgery
#3
Julio Rama-López, Meritxell Tomás-Fernandez, César García-Garza, Milton Martínez-Madrigal
BACKGROUND: Anterior cervical fixation has been used since 1967 for multiple pathologies like traumatism, compressive myelopathy, or spinal infections. METHODS: We report the case of a patient who had undergone cervical spine surgery 10 years previously and presented to our clinic with a pharyngeal fistula due to surgical screw displacement that was treated by transoral endoscopic surgery. RESULTS: The immediate postoperative period occurred without incidence and complete odynophagia resolution...
December 5, 2017: Head & Neck
https://www.readbyqxmd.com/read/29206325/growing-incidence-of-thyroid-carcinoma-in-recent-years-factors-underlying-overdiagnosis
#4
REVIEW
Alvaro Sanabria, Luiz P Kowalski, Jatin P Shah, Iain J Nixon, Peter Angelos, Michelle D Williams, Alessandra Rinaldo, Alfio Ferlito
There is an increasing incidence of well-differentiated thyroid cancer worldwide. Much of the increase is secondary to increased detection of small, low-risk tumors, with questionable clinical significance. This review addresses the factors that contribute to the increasing incidence and considers environmental, and patient-based and clinician-led influences. Articles addressing the causes of the increased incidence were critically reviewed. A complex interplay of environmental, medical, and social pressures has resulted in increased awareness of the thyroid disease risk, increased screening of thyroid cancers, and increased diagnosis of thyroid cancers...
December 5, 2017: Head & Neck
https://www.readbyqxmd.com/read/29206324/ahns-series-do-you-know-your-guidelines-evidence-based-management-of-oral-cavity-cancers
#5
Amarbir Gill, Nilesh Vasan, Babak Givi, Arjun Joshi
Oral cavity squamous cell carcinoma (OCSCC) is the most common nonmelanoma head and neck cancer in the world, with an estimated 405 000 new cases expected each year. Subsites of the oral cavity include the alveolar ridge, buccal mucosa, anterior tongue, tonsillar pillar, retromolar trigone, hard palate, gingiva, and floor of the mouth. In this issue of the AHNS "Do you know your guidelines?" series, we review the evidence-based approach to the management of oral cavity carcinomas based on the framework provided by the National Comprehensive Cancer Network (NCCN) Clinical Practice Guidelines in Oncology...
December 5, 2017: Head & Neck
https://www.readbyqxmd.com/read/29206321/factors-affecting-operative-time-in-robotic-thyroidectomy
#6
Chang Myeon Song, Youn Il Jang, Yong Bae Ji, Jeong Seon Park, Dong Sun Kim, Kyung Tae
BACKGROUND: The purpose of this study was to evaluate factors related to operative time in robotic thyroidectomy. METHODS: We retrospectively analyzed 240 patients who underwent robotic thyroidectomy. The total thyroidectomy cases and lobectomy cases were both categorized into those with long operative times (LOTs; upper 25% of cases) and those with short operative times (SOTs; lower 25%). RESULTS: Among the total thyroidectomy cases, body mass index (BMI) ≥23 kg/m2 (hazard ratio [HR] 5...
December 5, 2017: Head & Neck
https://www.readbyqxmd.com/read/29193596/superiorly-based-facial-artery-musculomucosal-flap-a-versatile-pedicled-flap
#7
Ilyes Berania, François Lavigne, Akram Rahal, Tareck Ayad
BACKGROUND: The superiorly based facial artery musculomucosal (FAMM) flap is pedicled on the angular artery. This flap offers a well-vascularized mucosal surface allowing closure of medium size defects, most frequently within the oral cavity and intranasal region. METHODS: We describe a superiorly based harvest of the FAMM flap, which may be used for closure of multiple head and neck surgical defects. An operative technique video is provided, which can be viewed online...
November 29, 2017: Head & Neck
https://www.readbyqxmd.com/read/29171929/ahns-series-do-you-know-your-guidelines-principles-of-treatment-for-locally-advanced-or-unresectable-head-and-neck-squamous-cell-carcinoma
#8
Cory D Fulcher, Missak Haigentz, Thomas J Ow
This article is a continuation of the "Do You Know Your Guidelines" series, initiated by the Education committee of the American Head and Neck Society. Treatment guidelines for advanced head and neck squamous cell carcinoma are reviewed here, including the critical roles of radiotherapy, chemotherapy, and the recent application of immunotherapy agents. We will be limiting this discussion to include cancers of the oral cavity, oropharynx, hypopharynx, and larynx. It should be noted that much of the article pertains to human papillomavirus (HPV)-negative oropharyngeal cancer where applicable, as HPV-positive oropharyngeal squamous cell carcinoma carries a different natural history, different prognosis, and now different staging criteria...
November 24, 2017: Head & Neck
https://www.readbyqxmd.com/read/29160008/clinical-diagnosis-and-treatment-outcomes-for-parapharyngeal-space-schwannomas-a-single-institution-review-of-21-cases
#9
Yoichiro Sato, Yorihisa Imanishi, Toshiki Tomita, Hiroyuki Ozawa, Koji Sakamoto, Ryoichi Fujii, Seiji Shigetomi, Noboru Habu, Kuninori Otsuka, Yoshihiro Watanabe, Mariko Sekimizu, Kaoru Ogawa
BACKGROUND: Because the incidence of schwannoma arising from the parapharyngeal space (PPS) is very low, no studies have analyzed extirpation methods and postoperative neurological complications exclusively in PPS schwannomas. METHODS: The preoperative diagnosis and clinical outcomes of surgical treatment in 21 patients with PPS schwannoma who underwent surgery were investigated. RESULTS: Neurological deficit of the involved nerve developed in all patients regardless of the extirpation method used...
November 21, 2017: Head & Neck
https://www.readbyqxmd.com/read/29159978/ahns-series-do-you-know-your-guidelines-guideline-recommendations-for-head-and-neck-cancer-of-unknown-primary-site
#10
Antoine Eskander, Tamer Ghanem, Amit Agrawal
This article reviews the clinical practice guidelines for head and neck oncology focusing on the management of head and neck cancers of unknown primary (CUP). The primary purpose of this series is to raise awareness of the current guidelines in head and neck oncology by reviewing the recommendations and the evidence supporting such recommendations, particularly those published by the National Comprehensive Cancer Network (NCCN). We review the importance of a thorough history and physical examination, the impact of the American Joint Committee on Cancer (AJCC) eighth edition changes and the importance of immunohistochemistry, the timing and type of imaging, the role of panendoscopy and tonsillectomy (palatine and lingual), and the role of surgery, radiation, and chemotherapy in the primary management of these tumors...
November 21, 2017: Head & Neck
https://www.readbyqxmd.com/read/29155481/peroxisome-proliferator-activated-receptor-gamma-stimulation-for-prevention-of-5-fluorouracil-induced-oral-mucositis-in-mice
#11
Mariangela Sottili, Monica Mangoni, Chiara Gerini, Giulia Salvatore, Francesca Castiglione, Isacco Desideri, Pierluigi Bonomo, Icro Meattini, Daniela Greto, Mauro Loi, Giulio Francolini, Marco Perna, Roberta Grassi, Giampaolo Biti, Lorenzo Livi
BACKGROUND: Oral mucositis is a side effect of treatment regimens containing 5-fluorouracil (5-FU). The purpose of this study was to present our evaluation to see if rosiglitazone (RGZ) protected normal tissues from chemotherapy-induced oral mucositis. METHODS: C57BL/6J mice were treated with 5-FU for 5 days, with or without RGZ. Mice were euthanized after 5, 8, 11, or 15 days, and mucosal segments were collected. RESULTS: The RGZ did not affect the 5-FU-induced decrease in mouse body weight...
November 20, 2017: Head & Neck
https://www.readbyqxmd.com/read/29155480/intensity-modulated-radiotherapy-for-elderly-patients-with-nasopharyngeal-carcinoma
#12
Caineng Cao, Qiaoying Hu, Xiaozhong Chen
BACKGROUND: The purpose of this study was to evaluate the clinical outcomes and patterns of failure after intensity-modulated radiotherapy (IMRT) for elderly patients with nasopharyngeal carcinoma (NPC). METHODS: Fifty-two patients treated with IMRT were eligible for study inclusion. Comorbidity was rated using the Adult Comorbidity Evaluation-27 (ACE-27) system. RESULTS: Twenty-six patients (50.0%) had an ACE-27 score of 1; and 6 (11.5%) had an ACE-27 score of 2...
November 20, 2017: Head & Neck
https://www.readbyqxmd.com/read/29155476/reply-to-the-letter-to-the-editor-extracapsular-dissection-versus-superficial-parotidectomy-in-benign-parotid-gland-tumors-the-vienna-medical-school-experience
#13
LETTER
Boban M Erovic, Lorenz Kadletz
No abstract text is available yet for this article.
November 20, 2017: Head & Neck
https://www.readbyqxmd.com/read/29155470/safety-and-effectiveness-of-endovascular-embolization-or-stent-graft-reconstruction-for-treatment-of-acute-carotid-blowout-syndrome-in-patients-with-head-and-neck-cancer-case-series-and-systematic-review-of-observational-studies
#14
Daniel J Y Wong, Christopher Donaldson, Leon T Lai, Andrew Coleman, Charles Giddings, Lee-Anne Slater, Ronil V Chandra
BACKGROUND: Indications for treatment and outcomes after endovascular management of carotid blowout syndrome for patients with head and neck cancer are not well defined. We investigated the safety and effectiveness of endovascular embolization and stent-graft reconstruction. METHODS: A literature review was performed for studies published between 2001 and 2015 with relevance to treatment outcomes. Our institutional database was examined to identify patients treated with endovascular techniques...
November 20, 2017: Head & Neck
https://www.readbyqxmd.com/read/29155466/letter-to-the-editor-regarding-extracapsular-dissection-versus-superficial-parotidectomy-in-benign-parotid-gland-tumors-the-vienna-medical-school-experience
#15
LETTER
https://www.readbyqxmd.com/read/29155463/free-gracilis-muscle-transfer-for-smile-reanimation-after-treatment-for-advanced-parotid-malignancy
#16
Callum Faris, Alyssa Heiser, Tessa Hadlock, Nate Jowett
BACKGROUND: The purpose of this study was to characterize the outcomes of free gracilis muscle transfer for delayed smile reanimation after radical parotidectomy. METHODS: A retrospective chart review of patients who underwent free gracilis muscle transfer for smile reanimation after radical parotidectomy between 2003 and 2016 was performed. Patient-reported quality of life (Facial Clinimetric Evaluation Scale [FaCE]), physician-reported facial function ("eFACE" facial grading scale), and oral commissure excursion were compared preoperatively and postoperatively...
November 20, 2017: Head & Neck
https://www.readbyqxmd.com/read/29149536/letter-to-the-editor-regarding-robotic-or-non-robotic-transoral-laryngectomy
#17
LETTER
Jose Granell, Mario Fernandez-Fernandez, Raimundo Gutierrez-Fonseca
No abstract text is available yet for this article.
November 17, 2017: Head & Neck
https://www.readbyqxmd.com/read/29149525/top-10-research-priorities-in-head-and-neck-cancer-results-of-an-alberta-priority-setting-partnership-of-patients-caregivers-family-members-and-clinicians
#18
Leah A Lechelt, Jana M Rieger, Katherine Cowan, Brock J Debenham, Bernie Krewski, Suresh Nayar, Akhila Regunathan, Hadi Seikaly, Ameeta E Singh, Andreas Laupacis
BACKGROUND: The epidemiology, etiology, and management of head and neck cancer are evolving. Understanding the perspectives and priorities of nonresearchers regarding treatment uncertainties is important to inform future research. METHODS: Using the James Lind Alliance approach, patients, caregivers, and clinicians responded to a survey regarding their unanswered questions about treating and managing head and neck cancer. Distinct uncertainties were extracted from responses and sorted into themes...
November 17, 2017: Head & Neck
https://www.readbyqxmd.com/read/29149496/predictive-factors-for-osteoradionecrosis-of-the-jaws-a-retrospective-study
#19
Hans P Sathasivam, Gareth R Davies, Nicholas M Boyd
BACKGROUND: Osteoradionecrosis of the jaw (ORNJ) is a well-recognized complication of radiotherapy. The purpose of this study was to assess predictive factors for the development of ORNJ. METHODS: A retrospective study of 325 patients with head and neck squamous cell carcinoma (HNSCC) treated at one institution between January 1, 1999, and December 31, 2008, was conducted. Outcome measure was the presence/absence of ORNJ. Time to event was recorded and Cox proportional hazard regression analysis was used to determine statistically significant predictive factors...
November 17, 2017: Head & Neck
https://www.readbyqxmd.com/read/29149475/reply-to-letter-to-the-editor-regarding-robotic-or-non-robotic-transoral-laryngectomy
#20
LETTER
Neerav Goyal, Emily Funk, David Goldenberg
No abstract text is available yet for this article.
November 17, 2017: Head & Neck
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