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FEMS Microbiology Reviews

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https://www.readbyqxmd.com/read/28430946/forgotten-fungi-the-gut-mycobiome-in-human-health-and-disease
#1
Chloe E Huseyin, Paul W O'Toole, Paul D Cotter, Pauline D Scanlan
The human body is home to a complex and diverse microbial ecosystem that plays a central role in host health. This includes a diversity of fungal species that is collectively referred to as our 'mycobiome'. Although research into the mycobiome is still in its infancy, its potential role in human disease is increasingly recognised. Here we review the existing literature available on the human mycobiota with an emphasis on the gut mycobiome, including how fungi interact with the human host and other microbes...
April 18, 2017: FEMS Microbiology Reviews
https://www.readbyqxmd.com/read/28419240/from-nano-to-micro-using-nanotechnology-to-combat-microorganisms-and-their-multidrug-resistance
#2
Michal Natan, Ehud Banin
The spread of antibiotic resistance and increasing prevalence of biofilm-associated infections is driving demand for new means to treat bacterial infection. Nanotechnology provides an innovative platform for addressing this challenge, with potential to manage even infections involving multidrug-resistant (MDR) bacteria. The current review summarizes recent progress over the last 2 years in the field of antibacterial nanodrugs, and describes their unique properties, mode of action and activity against MDR bacteria and biofilms...
April 13, 2017: FEMS Microbiology Reviews
https://www.readbyqxmd.com/read/28419231/antibiotic-resistance-in-staphylococcus-aureus-current-status-and-future-prospects
#3
Timothy J Foster
The major targets for antibiotics in staphylococci are (i) the cell envelope, (ii) the ribosome and (iii) nucleic acids. Several novel targets emerged from recent targeted drug discovery programmes including the ClpP protease and FtsZ from the cell division machinery. Resistance can either develop by horizontal transfer of resistance determinants encoded by mobile genetic elements viz plasmids, transposons and the staphylococcal cassette chromosome or by mutations in chromosomal genes. Horizontally acquired resistance can occur by one of the following mechanisms: (i) enzymatic drug modification and inactivation, (ii) enzymatic modification of the drug binding site, (iii) drug efflux, (iv) bypass mechanisms involving acquisition of a novel drug-resistant target, (v) displacement of the drug to protect the target...
April 13, 2017: FEMS Microbiology Reviews
https://www.readbyqxmd.com/read/28402441/mining-prokaryotes-for-antimicrobial-compounds-from-diversity-to-function
#4
Vittorio Tracanna, Anne de Jong, Marnix H Medema, Oscar P Kuipers
The bacterial kingdom provides a major source of antimicrobials that can either be directly applied or used as scaffolds to further improve their functionality in the host. The rapidly increasing amount of bacterial genomic, metabolomic and transcriptomic data offers unique opportunities to apply a variety of approaches to mine for existing and novel antimicrobials. Here, we discuss several powerful mining approaches to identify novel molecules with antimicrobial activity across structurally diverse natural products, including ribosomally synthesized and posttranslationally modified peptides, nonribosomal peptides and polyketides...
April 11, 2017: FEMS Microbiology Reviews
https://www.readbyqxmd.com/read/28402413/regulation-of-heat-shock-genes-in-bacteria-from-signal-sensing-to-gene-expression-output
#5
Davide Roncarati, Vincenzo Scarlato
The heat-shock response is a mechanism of cellular protection against sudden adverse environmental growth conditions and results in the prompt production of various heat-shock proteins. In bacteria, specific sensory biomolecules sense temperature fluctuations and transduce intercellular signals that coordinate gene expression outputs. Sensory biomolecules, also known as thermosensors, include nucleic acids (DNA or RNA) and proteins. Once a stress signal is perceived, it is transduced to invoke specific molecular mechanisms controlling transcription of genes coding for heat-shock proteins...
April 11, 2017: FEMS Microbiology Reviews
https://www.readbyqxmd.com/read/28369623/the-hidden-life-of-integrative-and-conjugative-elements
#6
François Delavat, Ryo Miyazaki, Nicolas Carraro, Nicolas Pradervand, Jan Roelof van der Meer
Integrative and conjugative elements (ICEs) are widespread mobile DNA that transmit both vertically, in a host-integrated state, and horizontally, through excision and transfer to new recipients. Different families of ICEs have been discovered with more or less restricted host ranges, which operate by similar mechanisms but differ in regulatory networks, evolutionary origin and the types of variable genes they contribute to the host. Based on reviewing recent experimental data, we propose a general model of ICE life style that explains the transition between vertical and horizontal transmission as a result of a bistable decision in the ICE-host partnership...
March 25, 2017: FEMS Microbiology Reviews
https://www.readbyqxmd.com/read/28369412/molecular-mechanisms-of-biofilm-based-antibiotic-resistance-and-tolerance-in-pathogenic-bacteria
#7
Clayton W Hall, Thien-Fah Mah
Biofilms are surface-attached groups of microbial cells encased in an extracellular matrix that are significantly less susceptible to antimicrobial agents than non-adherent, planktonic cells. Biofilm-based infections are, as a result, extremely difficult to cure. A wide range of molecular mechanisms contribute to the high degree of recalcitrance that is characteristic of biofilm communities. These mechanisms include, among others, interaction of antimicrobials with biofilm matrix components, reduced growth rates and the various actions of specific genetic determinants of antibiotic resistance and tolerance...
March 25, 2017: FEMS Microbiology Reviews
https://www.readbyqxmd.com/read/28369307/antimicrobial-resistance-in-mycobacterium-tuberculosis-mechanistic-and-evolutionary-perspectives
#8
Sebastian M Gygli, Sonia Borrell, Andrej Trauner, Sebastien Gagneux
Antibiotic-resistant Mycobacterium tuberculosis strains are threatening progress in containing the global tuberculosis epidemic. Mycobacterium tuberculosis is intrinsically resistant to many antibiotics, limiting the number of compounds available for treatment. This intrinsic resistance is due to a number of mechanisms including a thick, waxy, hydrophobic cell envelope and the presence of drug degrading and modifying enzymes. Resistance to the drugs which are active against M. tuberculosis is, in the absence of horizontally transferred resistance determinants, conferred by chromosomal mutations...
March 25, 2017: FEMS Microbiology Reviews
https://www.readbyqxmd.com/read/28333270/environmental-and-genetic-modulation-of-the-phenotypic-expression-of-antibiotic-resistance
#9
Diarmaid Hughes, Dan I Andersson
Antibiotic resistance can be acquired by mutation or horizontal transfer of a resistance gene, and generally an acquired mechanism results in a predictable increase in phenotypic resistance. However, recent findings suggest that the environment and/or the genetic context can modify the phenotypic expression of specific resistance genes/mutations. An important implication from these findings is that a given genotype does not always result in the expected phenotype. This dissociation of genotype and phenotype has important consequences for clinical bacteriology and for our ability to predict resistance phenotypes from genetics and DNA sequences...
March 8, 2017: FEMS Microbiology Reviews
https://www.readbyqxmd.com/read/28333226/exploring-the-human-microbiome-from-multiple-perspectives-factors-altering-its-composition-and-function
#10
David Rojo, Celia Méndez-García, Beata Anna Raczkowska, Rafael Bargiela, Andrés Moya, Manuel Ferrer, Coral Barbas
Our microbiota presents peculiarities and characteristics that may be altered by multiple factors. The degree and consequences of these alterations depend on the nature, strength and duration of the perturbations as well as the structure and stability of each microbiota. The aim of this review is to sketch a very broad picture of the factors commonly influencing different body sites, and which have been associated with alterations in the human microbiota in terms of composition and function. To do so, first, a graphical representation of bacterial, fungal and archaeal genera reveals possible associations among genera affected by different factors...
February 25, 2017: FEMS Microbiology Reviews
https://www.readbyqxmd.com/read/28333307/formation-physiology-ecology-evolution-and-clinical-importance-of-bacterial-persisters
#11
Bram Van den Bergh, Maarten Fauvart, Jan Michiels
Persisters are transiently tolerant variants that allow populations to avoid eradication by antibiotic treatment. Their antibiotic tolerance is non-genetic, not inheritable and results from a phenotypic switch from the normal, sensitive cell type to the tolerant, persister state. Here we give a comprehensive overview on bacterial persistence. We first define persistence, summarize the various aspects of persister physiology and show their heterogeneous nature. We then focus on the role of key cellular processes and mechanisms controlling the formation of a subpopulation of tolerant cells...
February 15, 2017: FEMS Microbiology Reviews
https://www.readbyqxmd.com/read/28364730/genetics-and-evolution-of-yersinia-pseudotuberculosis-o-specific-polysaccharides-a-novel-pattern-of-o-antigen-diversity
#12
Johanna J Kenyon, Monica M Cunneen, Peter R Reeves
O-antigen polysaccharide is a major immunogenic feature of the lipopolysaccharide of Gram-negative bacteria, and most species produce a large variety of forms that differ substantially from one another. There are 18 known O-antigen forms in the Yersinia pseudotuberculosis complex, which are typical in being composed of multiple copies of a short oligosaccharide called an O unit. The O-antigen gene clusters are located between the hemH and gsk genes, and are atypical as 15 of them are closely related, each having one of five downstream gene modules for alternative main-chain synthesis, and one of seven upstream modules for alternative side-branch sugar synthesis...
March 1, 2017: FEMS Microbiology Reviews
https://www.readbyqxmd.com/read/28364729/intestinal-microbiome-landscaping-insight-in-community-assemblage-and-implications-for-microbial-modulation-strategies
#13
Sudarshan A Shetty, Floor Hugenholtz, Leo Lahti, Hauke Smidt, Willem M de Vos
High individuality, large complexity and limited understanding of the mechanisms underlying human intestinal microbiome function remain the major challenges for designing beneficial modulation strategies. Exemplified by the analysis of intestinal bacteria in a thousand Western adults, we discuss key concepts of the human intestinal microbiome landscape, i.e. the compositional and functional 'core', the presence of community types and the existence of alternative stable states. Genomic investigation of core taxa revealed functional redundancy, which is expected to stabilize the ecosystem, as well as taxa with specialized functions that have the potential to shape the microbiome landscape...
March 1, 2017: FEMS Microbiology Reviews
https://www.readbyqxmd.com/read/28364728/microbial-ecology-of-fermentative-hydrogen-producing-bioprocesses-useful-insights-for-driving-the-ecosystem-function
#14
Lea Cabrol, Antonella Marone, Estela Tapia-Venegas, Jean-Philippe Steyer, Gonzalo Ruiz-Filippi, Eric Trably
One of the most important biotechnological challenges is to develop environment friendly technologies to produce new sources of energy. Microbial production of biohydrogen through dark fermentation, by conversion of residual biomass, is an attractive solution for short-term development of bioH2 producing processes. Efficient biohydrogen production relies on complex mixed communities working in tight interaction. Species composition and functional traits are of crucial importance to maintain the ecosystem service...
March 1, 2017: FEMS Microbiology Reviews
https://www.readbyqxmd.com/read/27965320/staphylococcus-aureus-phagocyte-nadph-oxidase-and-chronic-granulomatous-disease
#15
Helene Buvelot, Klara M Posfay-Barbe, Patrick Linder, Jacques Schrenzel, Karl-Heinz Krause
Dysfunction of phagocytes is a relevant risk factor for staphylococcal infection. The most common hereditary phagocyte dysfunction is chronic granulomatous disease (CGD), characterized by impaired generation of reactive oxygen species (ROS) due to loss of function mutations within the phagocyte NADPH oxidase NOX2. Phagocytes ROS generation is fundamental to eliminate pathogens and to regulate the inflammatory response to infection. CGD is characterized by recurrent and severe bacterial and fungal infections, with Staphylococcus aureus as the most frequent pathogen, and skin and lung abscesses as the most common clinical entities...
March 1, 2017: FEMS Microbiology Reviews
https://www.readbyqxmd.com/read/27856492/forest-microbiome-diversity-complexity-and-dynamics
#16
Petr Baldrian
Globally, forests represent highly productive ecosystems that act as carbon sinks where soil organic matter is formed from residuals after biomass decomposition as well as from rhizodeposited carbon. Forests exhibit a high level of spatial heterogeneity and the importance of trees, the dominant primary producers, for their structure and functioning. Fungi, bacteria and archaea inhabit various forest habitats: foliage, the wood of living trees, the bark surface, ground vegetation, roots and the rhizosphere, litter, soil, deadwood, rock surfaces, invertebrates, wetlands or the atmosphere, each of which has its own specific features, such as nutrient availability or temporal dynamicy and specific drivers that affect microbial abundance, the level of dominance of bacteria or fungi as well as the composition of their communities...
March 1, 2017: FEMS Microbiology Reviews
https://www.readbyqxmd.com/read/27799279/non-canonical-transcription-initiation-the-expanding-universe-of-transcription-initiating-substrates
#17
Ivan Barvík, Dominik Rejman, Natalya Panova, Hana Šanderová, Libor Krásný
RNA polymerase (RNAP) is the central enzyme of transcription of the genetic information from DNA into RNA. RNAP recognizes four main substrates: ATP, CTP, GTP and UTP. Experimental evidence from the past several years suggests that, besides these four NTPs, other molecules can be used to initiate transcription: (i) ribooligonucleotides (nanoRNAs) and (ii) coenzymes such as NAD+, NADH, dephospho-CoA and FAD. The presence of these molecules at the 5΄ ends of RNAs affects the properties of the RNA. Here, we discuss the expanding portfolio of molecules that can initiate transcription, their mechanism of incorporation, effects on RNA and cellular processes, and we present an outlook toward other possible initiation substrates...
March 1, 2017: FEMS Microbiology Reviews
https://www.readbyqxmd.com/read/28087690/editorial-an-expanded-view-of-viruses
#18
EDITORIAL
Urs F Greber, Ralf Bartenschlager
No abstract text is available yet for this article.
January 2017: FEMS Microbiology Reviews
https://www.readbyqxmd.com/read/27576366/antibiotic-dialogues-induction-of-silent-biosynthetic-gene-clusters-by-exogenous-small-molecules
#19
REVIEW
Bethany K Okada, Mohammad R Seyedsayamdost
Natural products have traditionally served as a dominant source of therapeutic agents. They are produced by dedicated biosynthetic gene clusters that assemble complex, bioactive molecules from simple precursors. Recent genome sequencing efforts coupled with advances in bioinformatics indicate that the majority of biosynthetic gene clusters are not expressed under normal laboratory conditions. Termed 'silent' or 'cryptic', these gene clusters represent a treasure trove for discovery of novel small molecules, their regulatory circuits and their biosynthetic pathways...
January 2017: FEMS Microbiology Reviews
https://www.readbyqxmd.com/read/27566466/emerging-facets-of-prokaryotic-glycosylation
#20
REVIEW
Christina Schäffer, Paul Messner
Glycosylation of proteins is one of the most prevalent post-translational modifications occurring in nature, with a wide repertoire of biological implications. Pathways for the main types of this modification, the N- and O-glycosylation, can be found in all three domains of life-the Eukarya, Bacteria and Archaea-thereby following common principles, which are valid also for lipopolysaccharides, lipooligosaccharides and glycopolymers. Thus, studies on any glycoconjugate can unravel novel facets of the still incompletely understood fundamentals of protein N- and O-glycosylation...
January 2017: FEMS Microbiology Reviews
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